Title: The Enantioselective Synthesis of Conformationally Constrained Cyclic β-
Amino Acids. VOLUME: 2 ISSUE: 1. Author(s):Jason A. Miller and SonBinh T. Nguyen. Affiliation:Northwestern University,Department of
Chemistry, 2145 Sheridan Rd., Evanston, Illinois 60208-3113, USA.. Keywords:amino acids, cyclic
amino acids, enantioselective synthesis, conformationally constrained,
peptides, asymmetric synthesis. Abstract: Enantiomerically pure and conformationally constrained cyclic β-amino acids have been the subject of a vast amount of research across the chemical, biological, and medicinal disciplines. These valuable molecules are synthetic precursors for a wide variety of useful compounds that include natural products and modified
peptides. Many methods have been developed to prepare chiral cyclic β-amino acids in high optical purity. This mini-review will discuss some of the most recent and successful approaches. ...