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The WW domain is a protein module found in a wide range of signaling proteins. It is one of the smallest protein modules that folds as a monomer without disulfide bridges or cofactors. WW domains bind proteins containing short linear peptide motifs that are proline-rich or contain at least one proline. Although the WW domain was initially considered a cytoplasmic module, the proteins containing WW domains have also been localized in the cell nucleus. Moreover, these proteins have been documented to participate in co-activation of transcription and modulation of RNA polymerase II activity. The carboxy-terminal domain (CTD) of RNA polymerase II acts as an assembly platform for distinct WW domain-containing proteins that affect the function of the RNA polymerase II. The formation of complexes between CTD and WW domain-containing proteins is regulated by phosphorylation of the CTD. Since the CTD sequence is highly repetitive and a target of several post-translational modifications and ...
The overall objective of the proposed project is to harness a newly discovered, active transendothelial transport pathway, the caveolae pumping system, to provi...
Giardia lamblia is an early branching eukaryote, and although distinctly eukaryotic in its cell and molecular biology, transcription and translation in G. lamblia demonstrate important differences from these processes in higher eukaryotes. The cyclic octapeptide amanitin is a relatively selective inhibitor of eukaryotic RNA polymerase II (RNAP II) and is commonly used to study RNAP II transcription. Therefore, we measured the sensitivity of G. lamblia RNAP II transcription to alpha-amanitin and found that unlike most other eukaryotes, RNAP II transcription in Giardia is resistant to 1 mg/ml amanitin. In contrast, 50 microg/ml amanitin inhibits 85% of RNAP III transcription activity using leucyl-tRNA as a template. To better understand transcription in G. lamblia, we identified 10 of the 12 known eukaryotic rpb subunits, including all 10 subunits that are required for viability in Saccharomyces cerevisiae. The amanitin motif (amanitin binding site) of Rpb1 from G. lamblia has amino acid ...
The IUPHAR/BPS Guide to Pharmacology. amanitin ligand page. Quantitative data and detailed annnotation of the targets of licensed and experimental drugs.
55325-99-0 - GBHLBBPUSBXKSA-AGOVMNPFSA-N - alpha-Amanitin, 4-(2-mercapto-6-methoxy-L-tryptophan)-, S-oxide - Similar structures search, synonyms, formulas, resource links, and other chemical information.
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GO Terms Descrition:, RNA polymerase II activity, DNA binding, DNA-directed RNA polymerase activity, protein binding, nucleus, DNA-directed RNA polymerase II, core complex, transcription, DNA-templated, gastrulation, embryo development ending in birth or egg hatching, transferase activity, nucleotidyltransferase activity, mRNA transcription from RNA polymerase II promoter, metal ion binding, reproduction, mitotic spindle organization, exit from mitosis, asymmetric cell division, developmental process, protein methylation, hatching, nematode larval development, transcription from RNA polymerase II promoter ...
CHEMICAL ASPECTS: The chemical properties listed below have been detected and/or isolated from the following species: Amanita muscaria, Amanita pantherina, Amanita regalis, Amanita corthurnata, Amanita
Garcia J, Costa VM, Carvalho A, Baptista P, de Pinho PG, de Lourdes Bastos M, et al. Amanita phalloides poisoning: Mechanisms of toxicity and treatment. Food Chem Toxicol. 2015 Sep 12. 86:41-55. ...
... : identification pictures (images), habitat, edible or poisonous; taxonomy, etymology, synonyms, similar species
I just consumed 5 grams of Amanita Muscarias. If I want to go farther I will eat more later. Wish me luck. Trip report will follow.
1. The two subunits α and β of Halobacterium cutirubrum DNA-dependent RNA polymerase are required in equimolar amounts for RNA synthesis to occur in vitro at the maximum rate. 2. In the absence of bivalent cations no interaction occurs between α and β subunits or between the subunits and DNA. 3. Mn2+ causes the subunits to form a 1:1 complex that still does not bind to the template. 4. Mg2+ permits binding of the Mn2+-mediated complex to DNA. 5. The complete enzyme, αβ, is inhibited by rifampicin and only the β subunit relieves the inhibition when added in excess. 6. Rifampicin-insensitive, template-dependent RNA synthesis occurs in the presence of protein α alone provided an oligonucleotide with a 5′-purine terminus is supplied as primer. 7. In the primed reaction with the α protein and an oligonucleotide, the template specificity is independent of the ionic strength, in contrast with the marked effect of salt concentration on the template specificity of the complete enzyme. 8. It is ...
The death cap grows either singly or in groups, and typically occurs between July and October in Europe and North America, and from March to July in South Africa (4) . This deadly species contains two types of toxins. The effects of consuming even
Seven cases of amatoxin poisoning reported in this case series confirms the existence of deadly amatoxin-containing mushroom in our locality. Poisonous Amanita species have long been found in Hong Kong. Although local cases of amatoxin poisoning have not been reported in Hong Kong before 2013, it has been well-reported in mainland China.7 8 9 According to a report published by Guangzhou Municipal Centre for Disease Control and Prevention, there were 92 cases of mushroom poisoning with 13 deaths in the years 2002 to 2005.9 The reported species of mushroom involved in 70% of cases were the amatoxin-containing mushroom Amanita exitialis and the gastroenteritic mushroom Chlorophyllum molybdites.9 For amatoxin poisoning, the latency between ingestion and onset of symptoms was typically 6 to 24 hours.3 For our seven cases of amatoxin poisoning, this latency ranged from 8 to 12 (median, 11) hours. There were four male and three female patients, with a median age of 44 (range, 29-74) years. All cases ...
Legalon® SIL will be administered to patients with amatoxin poisoning diagnosed by history, gastrointestinal symptoms, elevated liver enzymes, and/or diagnostic assay (should one become available). Patients may or may not also demonstrate abnormalities in bilirubin and/or creatinine. Treatment consists of a 5 mg/kg loading dose followed by 20 mg/kg/day via continuous infusion. The treating physician is expected to administer supportive therapy of his/her choosing but consistent with best practices. Legalon® SIL will be stopped when coagulopathy is no longer present, and when liver function tests have returned significantly towards the normal range. Patients will be followed 7-14 days after the end of Legalon® SIL therapy with follow up lab studies ...
Legalon® SIL will be administered to patients with amatoxin poisoning diagnosed by history, gastrointestinal symptoms, elevated liver enzymes, and/or diagnostic assay (should one become available). Patients may or may not also demonstrate abnormalities in bilirubin and/or creatinine. Treatment consists of a 5 mg/kg loading dose followed by 20 mg/kg/day via continuous infusion. The treating physician is expected to administer supportive therapy of his/her choosing but consistent with best practices. Legalon® SIL will be stopped when coagulopathy is no longer present, and when liver function tests have returned significantly towards the normal range. Patients will be followed 7-14 days after the end of Legalon® SIL therapy with follow up lab studies ...
Looking for Amanita? Find out information about Amanita. : see mushroom mushroom, type of basidium fungus characterized by spore-bearing gills on the underside of the umbrella- or cone-shaped cap. The name... Explanation of Amanita
What have we done we have to go so far away just to hear it to forget what we are in the forest itll be different this time when we come back it will Amanita light it up at last or whats left of it Im not…
The genus Lepiota lacks a volva, but the veil is present forming a ring on the stem. The genus is closely related to Amanita, from which it differs in the absence of the volva, or perhaps more properl...
Has anyone ever worked with tagetitoxin, a selective transcription inhibitor of chloroplast with arabidopsis? I would like to know who sells tagetitoxin, and at which concentrations it is recommendable to work with on Arabidopsis. I would appriciate very much any info on this subject. Diana ,http://bgumail.bgu.ac.il/agent/[email protected], leicaj at bgumail.bgu.ac.il ...
Notice to our users== Please help us to improve this small molecules wiki and our other wikis by registering for a wiki account through our normal feedback email. ==Important small molecule references== *[http://www.xenbase.org/literature/article.do?method=display&articleId=35021 Database of Small Molecules by Feldman and Hogue 2006] at [https://pubchem.ncbi.nlm.nih.gov/ PubChem] *[http://www.xenbase.org/literature/article.do?method=display&articleId=47903 Wnt/Notch by Myers and Krieg 2014] *[http://www.xenbase.org/literature/article.do?method=display&articleId=970 Ubiquitin-proteasome by Salic and King 2005] ==Alphabetical List of Small Molecules With Literature References== *[[1,3-Dicyclohexylurea]] *[[11-cis retinal]] *[[18alpha-glycyrretinic acid]] *[[2-deoxyadenosine]] *[[2-APB]] *[[2-Deoxyglucose]] *[[3,3,5-triiodothyronine (T3)]] *[[5HT (seratonin)]] *[[8-Pcpt-2-O-Me-cAMP-AM]] *[[activin]] *[[Adenosine, periodate oxidized]] *[[AG1296]] *[[AG1879]] *[[AGN193109]] *[[alpha-amanitin]] ...
Amanita submembranacea mushroom: identification pictures (images), habitat, edible or poisonous; taxonomy, etymology, synonyms, similar species
On the techtab, here:. http://www.amanitaceae.org?Amanita%20penetratrix. in the "material examined" data field.. Yes, this collection was dried in part.. The NEMF2015 foray produced many, many collections of solitary specimens of this species. The longest stipe measured was 220 mm, with over 130 mm underground.. A full range of cap colors were on view from white to pale tan to medium brown. If there are more than one species present in the mix, maybe we now have the material to figure that out.. My luck with collections of this species did a big turn around in New London. Many collectors produced good collections. My dryer didnnt fail. One or two collectors even got down to the absolute bottom of the stem and retrieved the saccate volva. Thanks to all of you.. Very best,. Rod ...
The nonprotein amino acids 2-amino-3-cyclopropylbutanoic acid and 2-amino-5-chloro-4-pentenoic acid were isolated from the mushroom Amanita cokeri. The cyclopropyl amino acid is toxic to the fungus Ce
Une base de donn es mycologique interactive avec fiches descriptives et photos de champignons, cartographie des r coltes, classification du r gne fongique, cl de d termination macroscopique des familles et cl s de d termination informatique pour chaque famille
Une base de donn es mycologique interactive avec fiches descriptives et photos de champignons, cartographie des r coltes, classification du r gne fongique, cl de d termination macroscopique des familles et cl s de d termination informatique pour chaque famille
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively.
Professor Joubert teaches how to extend a healthy cancer-free Lifespan to 122 years thanks to safe, efficient and cost friendly breakthrough protocols. Working on a documentary and book that redefines Medicine in light of new discoveries, ancient wisdoms, innovative research and holistic science, he can be nonetheless available to coach patients back to homeostasis, wellbeing & Joie de Vivre. On occasion, Pr. Joubert can also coach health professionals to better protect their holistic practice when they must deviate from outdated and-or irrational mainstream "standards of care" in order to genuinely serve their patients, evidence-strong Science and internationally recognized human rights. For details, see the links called "Contact" and "Mission" (under the "About" link).. ...
Martín, María P. & Hanna Johannesson. Battarea phalloides and B. stevenii, insight into a long-standing taxonomic puzzle. Mycotaxon 76: 67-75. 2000.. ABSTRACT: Two species of Battarrea Pers., B. phalloides and B. stevenii, have been cited in Europe. According to some authors, B. phalloides has a gelatinous volva and smaller basidiomata than B. stevenii. However, other authors consider that these characters are not enough to separate the taxa at the species level, and consider B. stevenii a synonym of B. phalloides. The main purpose of this work was to try to resolve the boundaries between the two taxa, not only based on macroscopic and microscopic characters, but also through molecular techniques. Thirty-five basidiomata from different geographical areas (Austria, Burundi, France, Hungary, Italy, Mexico, Spain) were examined to define the macroscopic and microscopic characters. The collections were investigated with regard to basidioma size, presence or absence of gelatinous hyphae in the ...
Galerinas grow primarily in spruce and pine forests. They grow on rotting logs and stumps, but also in places where wood has been worked. This small mushroom causes very serious poisonings. It ranks among the deadly poisonous, even though its size and appearance do not make it especially attractive to collectors. The toxins it contains are not broken down by heat, and remain poisonous even after being thoroughly cooked. Galerinas are almost as dangerous as the much better-known death cap (Amanita phalloides) and even contains similar toxins. A fatal dose for an adult is around 10-15 mushrooms - considering how small and thin it is, that is not very much material. Poisonings also have a similar Phalloidin effect - damage to liver and kidneys. The smaller number of poisonings, compared to the death cap, is somewhat due to its relative scarcity, but mostly because most pickers regard all small mushrooms growing from stumps as inedible toadstools.. ...
This page has the full text of an article which first appeared in the Santa Cruz Sentinal on the heroic efforts of Dr. Todd Mitchell, Santa Cruz Dominican Hospital, to save the lives of a family of six who had eaten the death cap mushroom, Amanita phalloides.
Bas (1969): AUSTRIA: Ca. Vienna, s.d. Hagenbrünn s.n. (PR). CROATIA: Dalmatian Islands, Isl. Ugljan, 25.xi.1964 M. Tortič s.n. (fragments in L). CZECH REPUBLIC: CENTRAL BOHEMIAN REGION-Karlštejn, 5.ix.1952 S. Indelka s.n. (PR). ÚSTÍ NAD LABEM REGION-Libochovice nad Ohři, 19.ix.1961 Z. Neubauer s.n. (PR). FRANCE: OISE-Orry-la-Ville, viii.1949 H. Romagnesi s.n. (S). PYRÉNÉES ORIENTALES-ca. Perpignan, 11.xi.1966 A. Marchand s.n. (L). ITALY: TRENTO-Vela, NW of Trento, vi.1901 G. Bresadola s.n. (S). TUSCANY-Isl. Elba - Porteferraio, x.1913 Gabari s.n. (S). NETHERLANDS: UTRECHT-Utrecht, 31.viii.1953 C. Bas 150 (L), 18.ix.1953 C. Bas 206 (L); Zeist, 17.ix.1953 O. F. Uffelie et al. (in herb. Uffelie). SLOVAKIA: Saudorf ca. Bratislava, 12.ix.1948 F. Drascla s.n. (PR). U.K.: ENGLAND-Surrey - Horseley, 6.ix.1953 R. W. G. Dennis s.n. (L ...
DNA-dependent RNA polymerases catalyze the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, RPB6 is part of the clamp element and together with parts of RPB1 and RPB2 forms a pocket to which the RPB4-RPB7 subcomplex binds (By similarity).
Consumption of the death cap is a medical emergency requiring hospitalization. The four main categories of therapy for poisoning are preliminary medical care, supportive measures, specific treatments, and liver transplantation.[74]. Preliminary care consists of gastric decontamination with either activated carbon or gastric lavage; due to the delay between ingestion and the first symptoms of poisoning, it is common for patients to arrive for treatment many hours after ingestion, potentially reducing the efficacy of these interventions.[74][75] Supportive measures are directed towards treating the dehydration which results from fluid loss during the gastrointestinal phase of intoxication and correction of metabolic acidosis, hypoglycemia, electrolyte imbalances, and impaired coagulation.[74]. No definitive antidote is available, but some specific treatments have been shown to improve survivability. High-dose continuous intravenous penicillin G has been reported to be of benefit, though the exact ...
The mere thought of an identification error sends a chill down the spine of any mushroom lover: The death cap mushroom (Amanita phalloides), which resembles the common white button mushroom, contains one of the most deadly poisons found in nature, α-amanitin. This substance kills any cell without exception, whether it be healthy or cancerous. At the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) and the National Center for Tumor Diseases Heidelberg, immunologist Dr. Gerhard Moldenhauer, jointly with biochemist Professor Dr. Heinz Faulstich, Max Planck Institute for Medical Research, has now developed a method for destroying cancer cells using the dreaded fungal toxin without harming the body. The trick to accomplish this is to deliver the poison directly to the right address in the body using something that virtually serves as a cab. In this case, the cab is an antibody whose highly specific arms attach to a cancer-typical cellular surface protein called EpCAM. The ...
Looking for Hallucinogenic effect? Find out information about Hallucinogenic effect. fungal poisoning caused by ingestion of certain mushrooms , most commonly Amanita phalloides and Amanita muscaria and related species. Symptoms, caused by... Explanation of Hallucinogenic effect
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We have started work on some changes to the MO naming system. See this Google doc for more details and feel free to leave comments ...
Ophthalmologists perform work familiar to some military personnel. Jobs in this career are similar to the following job classifications in the Air Force (AFSC). Army (MOS). Navy (Ratings). ...
Identification and characterization of Mediator-containing RNA polymerase II holoenzyme. As an undergraduate student with Henry Pitot at the University of Wisconsin, I helped characterize the gene encoding the barbiturate-induced aldehyde dehydrogenase from rat liver. This project exposed me to the compelling idea that an environmental cue, in this case phenobarbital, can dramatically change the gene-expression profile of the hepatocyte. My Ph.D. thesis research with Rick Young at the Whitehead Institute/MIT pursued my growing fascination with the complicated process of how genes get turned on. I identified an "initiation factor" required for RNA polymerase II to begin transcription of protein-coding genes in yeast. I demonstrated that this factor was part of a large complex, which we called the SRB complex (for suppressor of RNA polymerase B/II), contemporaneously discovered and named Mediator by Roger Kornbergs lab. I went on to purify RNA polymerase II in complex with SRB complex/Mediator ...
The actin genes of Trypanosoma brucei are transcribed constitutively during the parasite life-cycle, by a polymerase sensitive to alpha-amanitin (1). The start region of the actin gene transcription unit was mapped by virtue of the accumulation of promoter-proximal transcripts which occurs following moderate UV irradiation (2 - 6). This region, located about 4 kilobases upstream from the genes, was able to direct transient expression of the bacterial Chloramphenicol Acetyl Transferase (CAT) gene in both bloodstream and procyclic forms of the parasite. The essential region of the promoter was defined by deletion, and appeared to be within 600 bp upstream from the putative transcription start site. It does not share significant homology with the other trypanosome promoters described so far (VSG, procyclin, rDNA), which all direct alpha-amanitin resistant transcription. ...
The pharmacologic inhibition of RNA Pol I is becoming a potentially important therapeutic strategy in cancer (7, 19, 23). The therapeutic index using Pol I inhibition relies at least in part on the fact that tumor cells are often found to be in an anabolic state, with higher levels of ribosome biosynthesis than their corresponding normal counterparts (7, 9, 43). A validated assay that can determine whether there is indeed an increase in Pol I activity in routinely obtained tissue specimens, as well as a similarly applicable pharmacodynamic marker of target inhibition, would be a valuable companion diagnostic for such therapeutic trials.. We developed a CISH assay to examine the level of expression of the 5′ETS/45S rRNA gene in routinely processed human clinical tissue FFPE specimens. In contrast to the highly stable 18S/28S rRNA, the 5′ETS region is processed cotranscriptionally and is short-lived, and hence well suited for use as a marker for Pol I transcription activity (17). As of now, we ...
Actinomycin G (ActD), a good known transcription inhibitors, offers been widely reported to induce cell apoptosis in several types of growth cells by inhibiting the anti-apoptotic gene transcriptions. cell routine police arrest and apoptosis consequently. The present research possess exposed a book system by which ActD prevents osteosarcoma cell proliferations and induce apoptosis, and will offer an useful idea to chemotherapy in long term treatment of osteosarcoma. s using ANOVA testing for evaluations. The worth 0.05 (*), 0.01 (**) and 0.001 (***) was assumed as the level of significance for the figure testing carried out. Outcomes Actinomycin G prevents expansion of MG63 human being osteosarcoma cells Actinomycin G (ActD) can be reported to create anti-cancer activity by joining to guanine residues and suppressing DNA-dependent RNA polymerase [23]. Nevertheless, the toxic effects of ActD on osteosarcoma cells are not elucidated fully. To define the anti-cancer activity of ActD on osteosarcoma ...
Upregulation of the Phthiocerol Dimycocerosate Biosynthetic Pathway by Rifampin-Resistant, rpoB Mutant Mycobacterium tuberculosis. Greg Bisson, Carolina Mehaffy, Corey Broeckling, Jessica Prenni, Dalin Rifat, Desomnd Lun, Marcos Burgos, Drew Weissman, Petros Karakousis and Karen Dobos. J. Bacteriology 194: 6441-6452 (December 2012). About 2 million people will die from tuberculosis (TB) this year. Thats about the same number of people who watched the Rockies play this year. Coincidence? Maybe not - after all both fields have someone named Belisle out there trying to keep things from getting out of hand. While figuring out how to make the Rockies successful is above our pay grade, one key reason that Mycobacterium tuberculosis (M. tb) is such a problem is drug resistance. M. tb. becomes resistant to the drug rifampin, a first line antibiotic, by mutating a region around the channel used by nucleic acids in the bacterial RNA Polymerase B subunit. If you think about it though, how can bacteria ...
However, According to Dr. John Rippon, a world expert on fungal diseases, "squirrels have an interesting adaptation that allows them to eat mushrooms containing deadly amanita-toxins without being affected There are three important chemicals in the amanitas. Two will knock you right off, but are destroyed in cooking. The third one is the interesting one: it consists of the second amanitin, bound tightly to a glycoprotein molecule. When we digest the mushroom, the enzymes in our gut break the bond between the toxin and the glycoprotein, leaving the toxin free to enter our bloodstream, while the glycoprotein is excreted (a glycoprotein is a mucus molecule, in case you dont know). What the squirrels have done is line their gut with a toxin-compatible glycoprotein, so that as soon as it gets split from its original glycoprotein molecule, it gets rebound to the squirrel glycoprotein, and excreted along with it. Obviously, the squirrels dont cook their food to destroy the first two molecules, but ...
Liu, X.; Farnung, L.; Wigge, C.; Cramer, P.: Cryo-EM structure of a mammalian RNA polymerase II elongation complex inhibited by α-amanitin. Journal of Biological Chemistry 293 (19), pp. 7189 - 7194 (2018 ...
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So, the cute little ones are formed in an ice tray (found at Harps grocery for $1!) with an organic oils melt & pour soap, found @ The Chemistry Store. M&P soaps are so fun and easy! Just like the name, you simply melt and pour. As for the larger gem molds, you have 2 options: 1. Make your own from appropriately sized gems and silicone molds, found here @ Make Your Own Molds. 2. You can purchase them premade from Renascent College or Flexible Molds. Im sure there are a few others out there with premade gemstone molds. I searched for quartz point soap molds or gemstone soap molds ...