GlaxoSmithKline has signed a deal to get exclusive rights to early-stage vaccines for Alzheimers disease being developed by Affiris, an Austrian biotechnology firm which stands to gain up to 430 million euros. - News - PharmaTimes

TY - JOUR. T1 - DNA epitope vaccine containing complement component C3d enhances anti-amyloid-β antibody production and polarizes the immune response towards a Th2 phenotype. AU - Movsesyan, Nina. AU - Mkrtichyan, Mikayel. AU - Petrushina, Irina. AU - Ross, Ted M.. AU - Cribbs, David H.. AU - Agadjanyan, Michael G.. AU - Ghochikyan, Anahit. N1 - Funding Information: This work was supported by funding from NIH: AG 20241 (DHC), NS 50895 (DHC), AG 00538 (DHC), NS 057395 (MGA), Alzheimers Association IIRG 036279 (AG). NM was supported by NIA training grant AG00096. Copyright: Copyright 2009 Elsevier B.V., All rights reserved.. PY - 2008/12/15. Y1 - 2008/12/15. N2 - We have engineered a DNA epitope vaccine that expresses 3 self-B cell epitopes of Aβ42 (3Aβ1-11), a non-self T helper (Th) cell epitope (PADRE), and 3 copies of C3d (3C3d), a component of complement as a molecular adjuvant, designed to safely reduce CNS Aβ. Immunization of mice with 3Aβ1-11-PADRE epitope vaccine alone generated only ...

Lemere CA, Beierschmitt A, Iglesias M, Spooner ET, Bloom JK, Leverone JF, Zheng JB, Seabrook TJ, Louard D, Li D, Selkoe DJ, Palmour RM, Ervin FR. Alzheimers disease abeta vaccine reduces central nervous system abeta levels in a non-human primate, the Caribbean vervet ...

The results from these seven human clinical trials demonstrate the potential for EpiCor to play a beneficial role in helping healthy individuals maintain a strong, healthy immune system.

/PRNewswire/ -- Menarini Ricerche is progressing with the clinical development of SEL24/MEN1703, and will be presenting the design of the ongoing First In...

Active Aβ immunotherapy in Alzheimers disease (AD) induces removal of Aβ and phosphorylated tau (ptau). Glycogen Synthase Kinase (GSK)-3β is a kinase, responsible for phosphorylation of tau, activation of which can be induced by phosphorylated double-stranded RNA dependent protein kinase (pPKR). Using a post-mortem cohort of immunised AD cases, we investigated the effect of Abeta immunisation on GSK-3β expression and pPKR ...

AIIMS will start human clinical trial of Covaxin. The DCGI had okayed human clinical trials. Covaxin has been developed by Bharat Biotech in collaboration with ICMR. ICMR is also studying efficacy of BCG in prevention of covid in elderly. - India Travel Times

Free Online Library: Ruthigen Announces First Patient Enrollment in the Phase 1/2 Human Clinical Trial of RUT58-60, a Broad-Spectrum Anti-Infective Drug Candidate Designed for Prophylactic Use During Invasive Surgery. by PR Newswire; Business News, opinion and commentary Antibiotics Product development Clinical trials

Biova has been and continues to be a great partner to work with, as they are committed to ongoing science through human clinical trials supporting the quality, safety and efficacy of BiovaFlex, BiovaBIO and BiovaDerm and BiovaPlex. The Biova Team is knowledgeable and a pleasure to work with and is very customer focussed. Biova support, quality product and professionalism has been instrumental in my ability to successfully grow the Canadian market with Biova. I look forward to many more years working together with Biova ...

In telecommunication, antenna noise temperature is the temperature of a hypothetical resistor at the input of an ideal noise-free receiver that would generate the same output noise power per unit bandwidth as that at the antenna output at a specified frequency. In other words, antenna noise temperature is a parameter that describes how much noise an antenna produces in a given environment. This temperature is not the physical temperature of the antenna. Moreover, an antenna does not have an intrinsic antenna temperature associated with it; rather the temperature depends on its gain pattern and the thermal environment that it is placed in. Antenna noise temperature has contributions from several sources: Galactic radiation Earth heating The sun Electrical devices The antenna itself Galactic noise is high below 1000 MHz. At around 150 MHz, it is approximately 1000K. At 2500 MHz, it has leveled off to around 10K. Earth has an accepted standard temperature of 290K. The level of the suns ...

Researchers at the National Institutes of Health are accelerating human clinical trials for what scientists hope is a promising new vaccine to combat the deadly Ebola virus. Phase 1 of the clinical trials, which were previously not expected to begin until the end of September, will start early...

A recently published monkey study showed complete protection in half of the rhesus monkeys included after they were exposed to SIV, a virus similar to HIV ...

In mice, an anti-ApoE antibody removed plaques from the brains parenchyma and blood vessels better than aducanumab. Importantly, it caused no microhemorrhages.. ...

Four HBV Product Candidates Advancing In Human Clinical Trials in 1H16 Three IND Filings in 2016 for Oral HBV Drug Candidates Targeting cccDNA, S-Antigen, and Core Protein New Business Unit Established to Maximize Value of Tekmiras Non-HBV Assets VANCOUVER, British … Continue reading →. ...

ProteoTech Inc. (ProteoTech) today announced that it has completed regulatory Investigational New Drug (IND) requirements and has been cleared by the FDA to initiate its Phase 1 human clinical

Angiotech Pharmaceuticals, a Vancouver, BC company, has announced suspension of enrollment in its U.S. and EU human clinical trials for the companys Vascu

The pharmaceutical industry needs better scientific models for testing drugs before they get to the proving ground of human clinical trials. Current lab

Virtual Testing by means of computer simulations of physical models contains a large potential for the improvement of the verification and certification process of an aircrafts high lift system.Rising system complexity (driven by the need for improved A/C efficiency) on one side and shortened development cycles on the other side lead to the need of an extension of the existing, classical test methods.This is why Airbus High Lift Test Department continuously works since a couple of years on the introduction of Virtual Testing as an additional, equivalent test means besides existing, established physical means of compliance such as Test Rigs (TR) and Real Time Simulators, the so called Functional Integration Benches (FIB).Besides the obvious need for highly representative, reliable and efficient computer models, modelling methods and simulation tools this also requires a corresponding Simulation Data- and Process-Management (SDPM), establishing a completely traceable simulation lifecycle ...

Cytokines have important roles in the control of bacterial and viral infections such as HIV-1. Interleukin 17 which is secreted by Th17 is one of these cytokines with a special role in controlling microbial infections. In the present study, adjuvant activity of Alum and Naloxone mixture has been studied on immune responses, especially IL-17 cytokine. Naloxone and Alum adjuvant are mixed with 10 µg of recombinant vaccine HIV-1-gag-pol-tat-env. Experimental groups, consisting of 36 inbred male Balb/c mice divided into six groups, were injected subcutaneouslyat days 0, 14 and 28 with total volume of 200 µl. 2 weeks after final injection, mouse spleens were removed in sterile conditions and used to prepare suspensions. Lymphocyte proliferation responses were evaluated with Brdu test and evaluation of cytokines IL-4, IL-17 and INF-γ were completed using ELISA kit, plus total antibody and antibody isotopes IgG1 and IgG2a using ELISA test. All results show that the mixture of Alum with Naloxone

Immunotherapy for Alzheimers disease (AD) relies on antibodies directed against toxic amyloid-beta peptide (Abeta), which circulate in the bloodstream and remove Abeta from the brain. In mouse models of AD, the administration of anti-Abeta antibodies directly into the brain, in comparison to the bl …