TY - JOUR. T1 - Effect of an aldose reductase inhibitor on alveolar bone loss associated with periodontitis in diabetic rats. AU - Kador, Peter F.. AU - Hamada, Tomofumi. AU - Reinhardt, Richard A.. AU - Blessing, Karen. PY - 2010/5/1. Y1 - 2010/5/1. N2 - Periodontitis is a lesser known but frequent complication of diabetes mellitus and is the major cause of tooth loss in patients with diabetes. Dental therapy for this complication is primarily focused on the control of oral infections. No current therapy directly addresses the potential effects of diabetes itself on this complication. In studies conducted in young normal control and streptozotocin diabetic rats (100 g) treated with and without the aldose reductase inhibitor (ARI) imirestat, experimental periodontitis was induced in one side of the mouth by 3 injections of lipopolysaccharide (LPS) from Escherichia coli 055:B5 9 into the palatal gingiva between the first and second maxillary molars at 48-hour intervals. The other control side was ...
Objective: In this study we have assessed the renal and cardiac consequences of ligature-induced periodontitis in both normotensive and nitric oxide (NO)-deficient (L-NAME-treated) hypertensive rats.Materials and methods: Oral L-NAME (or water) treatment was started two weeks prior to induction of periodontitis. Rats were sacrificed 3, 7 or 14 days after ligature placement, and alveolar bone loss was evaluated radiographically. Thiobarbituric reactive species (TBARS; a lipid peroxidation index), protein nitrotyrosine (NT; a marker of protein nitration) and myeloperoxidase activity (MPO; a neutrophil marker) were determined in the heart and kidney.Results: In NO-deficient hypertensive rats, periodontitis-induced alveolar bone loss was significantly diminished. In addition, periodontitis-induced cardiac NT elevation was completely prevented by L-NAME treatment. on the other hand L-NAME treatment enhanced MPO production in both heart and kidneys of rats with periodontitis. No changes due to ...
Journal of Shahid Sadoughi University of Medical Sciences ماهنامه علمی پژوهشی دانشگاه علوم پزشکی و خدمات بهداشتی درمانی شهید صدوقی یزد
This might be one of several explanations as to why elevated bacteria and the combination of specific pathogens in periodontal pockets can be linked to a history of ACS," said Stefan Renvert, DDS, PhD and Department of Health Sciences, Kristianstad University. "We also found that the amount of periodontal bacteria results in an inflammatory response that elevates the white blood cell counts and high sensitivity C-reactive protein levels, which has also been linked in past studies to heart disease.". It was also found that the extent of alveolar bone loss was significantly greater among subjects with ACS. Seventy-seven percent of the participants in the ACS group and 42 percent in the control group demonstrated evidence of periodontitis. The extent of bone loss was more severe in the ACS group than in the non-ACS group.. Another reason people diagnosed with ACS may have higher oral bacteria could be due to their infectious susceptibility and lack of an adequate host inflammatory response, which ...
Curcumin is a yellowish polyphenol extracted from the rizome of a herbaceous tropical plant. It has multiple biological activities described, including anti-inflammatory, antioxidant, antiangiogenic, immunomodulatory, cytotoxic, antimicrobial and pro- and antiapoptotic activities. Its therapeutic application is actively evaluated in preclinical models and clinical studies of various diseases. In vivo use of curcumin is limited by its pharmacodynamic propereties, such as poor solubility in aqueous vehicles, low absorption rate in the gastrointestinal tract and short half-life in the peripheral circulation. The aim of this study was to evaluate the dose-response effect of a synthetic compound that is structurally to natural curcumin (CMC2.24) in a model of experimental periodontal disease that mimics the host-microbial interaction and the resultant inflammation and bone resorption that are hallmarks of this conditions in humans. Periodontal disease was induced in mice by injection of 30 ug LPS of ...
OBJECTIVE: The purpose of this study was to evaluate whether local administration of TIL could influence the expression of the inflammatory mediators IL-1β, TNF-α, MMP-8 and COX-2 in rats with experimental periodontitis (EP). METHODS: Twenty-four adult male rats (Rattus norvegicus, albinus, Wistar) were assigned to groups C, EP, EP-TIL (CControl group, EP-Periodontitis groups). On EP groups, a ligature was placed around maxillary 2nd molars on day 1. On group EP-TIL, 20 μL of TIL solution (1 mg/kg body weight) was injected into the subperiosteal palatal area adjacent to the maxillary 2nd molar every other day until euthanasia (day 11 ...
(2005) Young et al. Tissue Engineering. Tooth loss accompanied by alveolar bone resorption presents a significant clinical problem. We have investigated the utility of a tissue-engineering approach to provide corrective therapies for too...
Particularly suited for treatment of smaller defects and periodontal bone defects. Can be cut to shape and size in dry or wet conditions. Does not stick to itself and to instruments. Can be easily repositioned, if needed. Exceptional adaptability to surface contour after rehydration.. ...
Vitamins and minerals essential for improving the nutritional environment of periodontal bone and tissue.These statements have not been evaluated by the Food and Drug Administration (FDA). These products are not meant to diagnose, treat or cure any disease or medical condition. Please consult your doctor before starting any exercise or nutritional supplement program or before using these or any product during pregnancy or if you have a serious medical condition.
PROTOCOL OUTLINE: This is a randomized, double-blind, placebo controlled study. Patients are randomly assigned to receive placebo or conjugated estrogens and, if no prior hysterectomy, medroxyprogesterone. Patients also receive calcium supplementation therapy daily for 3 years.. Participants in the placebo group may be removed from study if bone loss exceeds 5% per year.. A study duration of 3 years is anticipated. ...
Purpose: The aim of this study was to compare vertical and horizontal mandibular alveolar bone resorption by measuring bone morphological variation in Kennedy Class II removable partial denture (RPD) wearers and non-wearers using cone-beam computed tomography (CBCT).. Materials and Methods: In total, 124 sites in the CBCT scans of 62 (29 RPD non-wearers, 33 RPD wearers) Kennedy Class II patients were analyzed retrospectively. Three-dimensional representations of the mandible with superimposed cross-sectional slices were developed with the CBCT scans to evaluate the mandibular alveolar height and width by measuring distances between the mandibular canal, mylohyoid ridge, alveolar crest, and lower border of the mandible in four regions (eight sites) of Kennedy Class II non-wearers and wearers of RPDs.. Results: Mandibular alveolar bone height and width were significantly lower in edentulous sites when compared with dentate sites in both Kennedy Class II non-wearers and wearers of RPDs (p , 0.05). ...
Oral bone loss is a major concern amongst a large population suffering from estrogen deficiency, osteoporosis and periodontal diseases. The clinical implication of oral bone loss is premature tooth loss. Mechanical loading has proven to be vital in maintaining the quantity and quality of the bone, particularly in impacted bone. Studies have shown that long bones (post-cranial) and alveolar bone (cranial) are both sensitive to mechanical environment through static and dynamic loading. It also has been suggested that whole body vibrations (WBV) at low-magnitude and high frequency are a non-invasive and non-pharmacological method to prevent bone loss, particularly in the long bones. However, not much has been said about the application of these low-magnitude high frequency loads on the alveolar bone. In this pilot study, it is determined if low magnitude of 0.3 g (where g = 9.8ms,super,-2,/super,) and high frequency of 50 Hz, localized vibrations can be transmitted to the alveolar bone and also ...
This study was planned to determine whether a short period dexamethasone treatment induce alveolar bone loss or not, therefore, twenty six male albino rabbits were divided into three groups as follow: Test groups I (10 rabbits) received 1.56 mg/kg dexamethasone intraperitoneal injection daily for two weeks, test group II (10 rabbits) received 3.12 mg/kg dexamethasone intraperitoneal injection daily, and the control group (6 rabbits) received saline solution for same period. The animals were sacrificed and histological sections were prepared from the alveolar bone of molar areas of mandible, as well as morphometric analysis of osteoclasts number was performed. The results showed a significant increase in the number of osteoclasts, which indicates that bone loss, is quite inevitable secondary to dexamethasone treatment even in a short period of treatment for two weeks.
In an article titled Periodontal Assessments of Postmenopausal Women Receiving Risedronate, a graduate of the Case Western Reserve University School of Dental Medicine, reports that drugs that are used to combat
Researchers at the University at Buffalo have been able to identify two key components in saliva that could be used to predict the amount of oral bone loss in future.
The treatment of intrabony defects is a real challenge in molar teeth as it is chronic, slowly progressing disease which needs timely intervention. Periodontal inflammation associated with intrabony defect is not a separate entity as it secondarily affects the pulp causing retrograde pulpitis. However, treatment of these lesions will be complicated due to extensive bone loss. The tooth was endodontically treated followed by periodontal surgery to eliminate the deep periodontal pocket and promote bone fill in osseous defect. PepGen P-15 composited with platelet rich plasma was utilized for enhancing bone formation. The combination of these graft materials provides synergistic effect on bone regeneration.
Researchers compared the effect of a daily atorvastatin 80 mg dose versus a 10 mg dose in a randomized, multi-center trial with 71 subjects with established atherosclerosis or risk factors for atherosclerosis. Patients were evaluated using F-Flurodexoyglucose positron emission tomography (FDG-PET) imaging. After 12 weeks, there was a significant reduction in periodontal inflammation in subjects randomized to the 80 mg dose (p=0.04). Reductions in periodontal inflammation were greatest in individuals with higher levels of periodontal inflammation at baseline (p=0.01) and in those with higher periodontal bone loss at baseline (p=0.03). The reductions in periodontal inflammation correlated with reductions in carotid inflammation (p,0.001). "The impact of high-dose statin was greatest in individuals with evidence of active periodontitis and was evident after a four-week treatment period," said lead author Sharath Subramanian, MD, Massachusetts General Hospital and Harvard Medical School, Boston. "We ...
Differing theories of the nature of periodontal disease progression have been proposed, but there is no convincing statistical evidence with which to choose between them. Three models for disease progression are developed, and their covariance structures are derived and shown to be hierarchical. The estimation of the covariance structures of...
Purpose: The purpose of this scholarly study is to evalute the anti-inflammatory ramifications of morus migra on experimentally-induced periodontitis in rats. Outcomes: Morus nigra treatment reduced tissues MMP-8 and MMP-13 amounts and there have been significant differences regarding tissue degrees of MMP-8 and MMP-13 between groupings PER and MN+PER (p=0.035, p=0.041). There have been no significant distinctions among all of the groupings serum degrees of MMP-8 and MMP-13 (p=0.067, p=0.082). In the histometric evaluation, alveolar bone loss was higher in the PER group compared to C and MN organizations (p=0.035). Immuno-histochemical staining of RANKL activities were found significantly lower (p=0.037) and OPG activities were found significantly higher in MN+PER group when compared to PER group (p=0.021). Summary: The present study shows that systemic administration of Morus nigra significantly inhibited the regional alveolar bone AC220 manufacturer resorption and contributes to periodontal ...
Results: No significant differences were found between both groups in survival, complications, or marginal bone resorption. One axially placed implant was lost at 58 months in group 1, rendering a cumulative survival estimate at 5 years of 96.7% and 98.3% in group 1 and the total sample, respectively (P = .317). Mechanical complications occurred in 16 patients (26.7%; n = 8 patients in each group; [P > .999]), consisting of fractures in the provisional prosthesis (n = 8 patients), chipped ceramics of the definitive prosthesis (n = 2 patients), loosening of prosthetic components (n = 5 patients), and fracture of an attachment screw (n = 1 patient). Biologic complications occurred in 5 patients (8.3%; group 1 = 4 patients; group 2 = 1 patient; [P = .161]), consisting of peri-implant pathology. The mean ± SD marginal bone loss was 2.02 ± 0.36 mm and 1.90 ± 0.69 mm for groups 1 and 2, respectively (P = .235). In group 1, the mean ± SD marginal bone loss was 1.92 ± 0.48 mm and 2.11 ± 0.44 mm ...
Parathyroid hormone is an endogenous hormone with potent anabolic and catabolic actions in bone. It has recently been approved for the treatment of osteoporosis and is marketed as FORTEO by Eli Lilly and Company. Numerous studies in humans have validated its use to increase bone mineral density and prevent fractures. Interest has also surfaced in its potential application in the treatment of non-osteoporotic fractures and several animal studies have supported this local application. Little is known regarding its use in treating conditions of the oral cavity, but animal studies suggest that bones of the oral cavity are responsive to the anabolic actions of PTH. Furthermore, a recent study indicated that in a canine model, PTH was effective at reversing periodontal bone loss. Studies from our laboratory indicate that patients with hyperparathyroidism (HPT) do not have an increase in periodontal disease as measured by attachment levels. In fact, in our patient population there was an increase in ...
The main finding is that the enhanced alveolar bone loss associated to age may be targeted by an appropriate dietary treatment. Our method uses biological knowledge expressed by Gene Ontology and generates a rule model associating this knowledge with minimal characteristic features of temporal gene expression profiles. The relatively low attack rate and also relative risk requires large sample sizes for free cialis generic testing hypotheses. From genes to function: the next challenge to understanding multiple sclerosis.. Recommendations for early diagnosis and intervention in autism spectrum disorders: an Italian-Israeli consensus conference. The purpose of this article is to reexamine some of the principles of correction. 6-Shogaol was shown to damage microtubules and discount generic cialis induce mitotic arrest. There was a weak association between adduct levels and daily cigarette consumption above 10 cigarettes per day. The results indicate that the PFD could be a useful tool for ...
The Straumann® Bone Level Tapered (BLT) Implant offers all the clinically proven features of the Straumann® Bone Level Implant line plus the advantages of a tapered implant body. This leads to excellent primary stability in soft bone and fresh extraction sockets. The tapered form adequately compresses the underprepared osteotomy. It also lets you effectively master your patients limited anatomy, such as facial undercuts, converging root tips, a concave jaw structure or narrow atrophied ridges ...
Australian Wine Cluster Supplementary Information Case Study Help, Case Study Solution & Analysis & Obesity induces gingival oxidative pressure, thats associated with the development of alveolar bone resorption. The antioxidant influence of hydrogen-load
Current therapeutics such as bisphosphonates or anabolic agents do not always effectively prevent or treat osteoporosis and inflammatory bone loss in rheumatoid...
I am new to the forum and tomorrow I am going in for the beginning of having dental implants due to bone loss! I have been so confused as to why I have had bone loss. I had PE with all 3 of my children and HELLP with my second. My youngest is 8 years old and I am approaching 49. My Mother had PE her first pregnancy and had dental bone loss issues. Back in the 1970s they told her here bone loss was due to her pregnancies. I am glad I decided to search for this. It gives me something to think about ...
31 years-old male patient was loss of anterior teeth for 1 year. . We have treated this case using Geistlich Bio-Oss® and Geistlich Bio-Gide® guide bone regeneration. After 6 months, the post-examination showed that that site had well-developed alveolar bone. After 1 year, permanent restoration was performed.. ...
... Definition Periodontal fiber is attached to the dentin of the root of the tooth by cementum and to the bone of the jaws by alveolar bone.
Bone loss is a problem that not only plagues the elderly, but the younger generation as well. This condition does not form overnight. Nobody can say that with just a ...
Atherosclerotic vascular disease is a leading cause of myocardial infarction and cerebrovascular accident, and independent associations with periodontal disease (PD) are reported. PD is caused by polymicrobial infections and aggressive immune responses. Genomic DNA of Porphyromonas gingivalis, the best-studied bacterial pathogen associated with severe PD, is detected within atherosclerotic plaque. We examined causal relationships between chronic P. gingivalis oral infection, PD, and atherosclerosis in hyperlipidemic ApoEnull mice. ApoEnull mice (n = 24) were orally infected with P. gingivalis for 12 and 24 weeks. PD was assessed by standard clinical measurements while the aorta was examined for atherosclerotic lesions and inflammatory markers by array. Systemic inflammatory markers serum amyloid A, nitric oxide, and oxidized low-density lipoprotein were analyzed. P. gingivalis infection elicited specific antibodies and alveolar bone loss. Fluorescent in situ hybridization detected viable P. gingivalis
Clinicians very often have seen marginal bone loss around dental implants at the crest level early on after implant placement and uncovering. Early clinical publications had suggested that this bone loss occurred during the first year of loading. Thus, numerous attempts have been made to minimize or eliminate such bone loss. However, the timing and reason for this bone loss are not always apparent. The objective of this study was to review the evidence regarding marginal bone loss around dental implants from the standpoint of biologic consequences to help understand marginal bone changes around dental implants. One hypothesis for the bone loss around these implants was related to the presence of bacteria in the interfaces between the implant and abutment connections. The literature was reviewed regarding the three major types of implant-abutment crestal connections, including butt-joint, platform-switched, and no interface (tissue-level or one-body). This review article revealed that 1.5 to 2.0 ...
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A range of regenerative treatments have been used for the treatment of periodontal infrabony defects. Guided tissue regeneration (GTR) and enamel matrix derivatives (EMD) are two popular treatment and they have both been used in combination with other treatment. This network meta-analysis was conducted to assess the potential effects of the various combinations. Unlike a [read the full story…]. ...
The suitability of a mouse model for host response in the induction of alveolar bone loss by Porphyromonas gingivalis was explored. The mouths of immunocompetent and severe combined immunodeficient (SCID) mice were infected with P. gingivalis ATCC 53977. P. gingivalis was not isolated from the mouths of these mice before infection, but was present at least 42 days after infection. P. gingivalis-specific IgG was present in sera from the infected, immunocompetent mice at the end of these experiments (42 days). Specific IgG was not present in sham-infected or uninfected immunocompetent mice, nor in any immunodeficient mice. Specific IgM was not present in any sera at 42 days. Infected, immunocompetent mice of two strains showed significant bone loss in comparison to sham-infected or uninfected immunocompetent mice (p | 0.05). Infected SCID mice, which are genetically lacking both B and T lymphocytes, also showed significant bone loss compared with sham-infected or uninfected SCID mice (p | 0.05
PURPOSE: The purpose of this animal study was to confirm that laser Doppler flowmetry (LDF) is a reproducible method for the assessment of maxillary and mandibular alveolar bone vascularity and that there is less vascularity in irradiated mandibular and maxillary bone compared to nonirradiated bone. MATERIALS AND METHODS: All maxillary and mandibular premolars and molars of 6 Gottingen minipigs were extracted. After a 3-month healing period, 3 minipigs received irradiation at a total dose of 24 Gy. Three months after irradiation, 5 holes were drilled in the residual alveolar ridge of each edentulous site in each minipig. Local microvascular blood flow around all 120 holes was recorded by LDF prior to implant placement. In 1 irradiated and 1 nonirradiated minipig, an additional hole was drilled in a right maxillary site to enable repeated LDF recordings. RESULTS: The alveolar bone appeared less vascularized in irradiated than in nonirradiated minipigs. The effect of radiation appeared more ...
Non-healing bone fractures and periodontal bone loss constitute significant clinical problems with few approved medical options. Bone repair is enhanced by the presence of osteoblasts or osteoblastic precursor cells. Subcutaneous adipose tissue is a plentiful, accessible, and replenishable source of human stromal cells for transplantation. In Phase I of this SBIR, we tested the hypothesis that human adipose tissue-derived stromal cells are capable of osteoblast function. Substantial in vitro data indicates that these stromal cells differentiate into cells biochemically and morphologically similar to osteoblasts. The ability of these cells to form bone in vivo was examined as well. Phase II of this SBIR will extend these in vivo experiments. Specific Aim 1 examines the ability of human adipose tissue-derived stromal cells to form ectopic bone in hydroxyapatite ceramic cubes implanted subcutaneously in immunodeficient mice. Specific Aim 2 explores whether the introduction of a modified bone ...
If you have been in practice long enough, you will have run into something like this eventually. This is a 76 year old farmer who has fairly obviously been "grinding his teeth". In fact, you would be making a correct assumption. Note that the tooth wear is much worse anteriorly than it is in the posterior. As we will eventually see, this is diagnostic of abrasion from bruxism. But notice a few other less obvious things. You see no occlusal amalgam fillings in the posterior teeth. You see no plaque or redness around the gingiva. You see no active decay anywhere. Furthermore, the patient has no periodontal bone loss in spite of a serious bruxing habit. On the other hand, you do see a few buccal composite fillings along with severe buccal-cervical wear. We can conclude the following from these observations:. This patient has probably never used too much sugar. We conclude this by the lack of amalgam fillings in the intact molars and the occlusal of #4, the one "surviving" premolar.. The patient has ...
Our understanding about periodontal disease progression improved tremendously during 1960s, when animal and human experiments demonstrated the role of bacteria in the initiation of gingivitis and periodontitis 1, 2. These studies led to the proposal of the model of bacterial etiology of periodontal disease. Further investigations in this field led to the advancement of our knowledge of pathogenic bacteria causing disease progression. Specific Gram-negative, anaerobic, or microaerophilic bacteria were implicated in the causation of periodontitis 3-7. During late 1970s and early 1980s protective and destructive roles of the immunoinflammatory responses were described in health and disease 8-14.. Most of the models of periodontal disease progression in the late 1980s stated that specific bacteria initiated the disease process by activating host responses, which were protective and destructive. The actual destruction of connective tissue and bone resulted primarily from inflammatory chemical ...
A polylactide-polyglicolide(PLA-PGL) has been documented clinically to enhance bone regeneration in closed bone defects and to sustain periodontal healing in intrabony defects. So far, there are no controlled clinical studies to compare the effect of the PLA-PGL with the effect of other "biological agents" in treating deep intrabony defects. Aim of the study: to compare treatment of deep intrabony defects with PLA-PGL(Fisiograft®,Ghimas,Italy) to an enamel-matrix-protein-derivative(EMD; Emdogain®,Straumann AG,Waldenburg,Switzerland). Nineteen patients, displaying 26 intrabony defects, were randomly treated with PLA-PGL (test) or with EMD(control). Soft tissue measurements were made at baseline and 6 months after. No differences in the investigated parameters were observed at baseline between groups. Wilcoxon and Mann-Whitney tests were used for statistics. Alpha-error was set 0.05, the power-of-the-study 0.57. No adverse healing response was observed. Six months after, sites treated with ...
Non-contained intrabony defect treated using cerabone®, collprotect® membrane and Straumann® Emdogain® - Dr. T. Schwaar (2 ...
Evaluation of the Effect of Buccolingual and Apicocoronal Positions of Dental Implants on Stress and Strain in Alveolar Bone by Finite Element Analysis
Calcium aids in development of strong bones and teeth. It also helps your heart, nerves, and muscles. Calcium deficiency often doesnt show symptoms right away, but leads to serious health problems over time. If calcium consumption isnt enough, your body may use the calcium from your bones instead, leading to bone loss.. Experts also believe that calcium deficiencies may be related to low bone mass and weakening of bones due to osteoporosis.. Calcium deficiency leads to convulsions and abnormal heart rhythm which can be life-threatening. Postmenopausal women experience greater bone loss due to changing hormones experiencing troubles absorbing calcium.The best sources of calcium are dairy products such as milk, yogurt, cheese, calcium-set tofu, and small fish with bones. Vegetables such as kale and broccoli also have calcium, and many cereals and grains are calcium-fortified.. ...
Overall marginal bone loss was not significantly different between the two treatment groups (EHC vs. IHC) at any time point. The mean difference of bone levels between EHC and IHC was 0.25 mm (95% CI: −0.18 to 0.69) at implant placement. Mean difference between IHC and EHC was −0.01 mm (95% CI: −0.34 to 0.36) at 3 months, 0.13 mm (95% CI: −0.48 to 0.22) at 6 months and 0.11 mm (95% CI: −0.45 to 0.25) at 12 months. All the implants showed good periodontal health at the 1-year-in-function visit, with no statistically significant differences between groups. At 12 months mean (± standard deviation) PI was 2 (± 1.5) for the EHC and 1.85 (± 1.58) for the IHC group (P = 0.57) with a mean difference between the two groups of 0.15 (95% CI: −0.56 to 0.85). Mean PD was 2.23 mm (± 0.52) for the EHC and 2.10 mm (± 0.39) for the IHC group (P = 0.39), with a mean difference between the two groups of 0.12 mm (95% CI: −0.08 to 0.33). At 12 months 41.4% of EHC and 43.6% of IHC implants ...
Objective The aim of the present study was to assess interventions and their consequences with regard to further bone loss at sites diagnosed with peri-implantitis. Materials and Methods In 2017, records of 70 patients diagnosed with moderate/severe peri-implantitis at >= 1 implant sites 4 years earlier were obtained. Changes of marginal bone levels during the study period assessed on radiographs and predictors of disease progression were identified by Cox regression and mixed linear modelling. Patient files were analysed for professional interventions related to the treatment of peri-implantitis. Results Mean bone loss (+/- SD) at implants diagnosed with moderate/severe peri-implantitis was 1.1 +/- 2.0 mm over the observation period of 3.3 years. While non-surgical measures including submucosal and/or supra-mucosal cleaning of implants were provided to almost all patients, surgical treatment of peri-implantitis was limited to a subgroup (17 subjects). Surgically treated implant sites ...
The molecular mechanisms controlling the differentiation of bone marrow stromal stem cells into osteoblasts remain mainly unknown. Similar results were found for the knockdown of the receptor- knockdown cells than control cells. Our data provide the first evidence that is involved in the osteogenic differentiation of bone tissue marrow stromal cells the legislation of the signaling pathway. Launch Osteoblasts differentiate from bone tissue marrow stromal cells (BMSCs), also called mesenchymal stem cells, that have the capacity to be adipocytes or fibroblasts [1]. Lately, individual alveolar-derived BMSCs (hAD-BMSCs) have already been effectively isolated and cultured [2]. These cells could be ideal for periodontal bone tissue regenerative medication because marrow bloodstream can be quickly aspirated from alveolar bone tissue during tooth removal and oral implant medical procedures [3, 4]. The bone tissue morphogenetic proteins (BMP) 2 signaling pathway can be an important regulator of ...
Ferreira CEA, Novaes AB Jr, Haraszthy VI, Bittencourt M, Martinelli CB, Luczyszyn SM. A clinical study of 406 sinus augmentations with 100% anorganic bovine bone. J Periodontol 2009;80(12):1920-1927.. Sinus grafting with anorganic bovine bone was performed in 222 patients requiring unilateral sinus grafting and 92 patients requiring bilateral sinus grafting; a total of 1,025 implants were placed (118 simultaneous with grafting and 907 at second stage surgery after 6-12 months). After 3 years, the implant survival rate was 98.1% (19 implants were lost), with no significant differences in survival between implants with rough or machined surfaces, or between implants placed in various heights of native bone. Histomorphometry showed 39.0 ± 12% new bone formation and 52.9% ± 9.3% marrow space.. Song D-W, Lee D-W, Kim C-K, Park K-H, Moon I-S. Comparative analysis of peri-implant marginal bone loss based on microthread location: a 1-year prospective study after loading. J Periodontol ...
Results: One patient (11-mm group) died before the 12-month evaluation and one patient (6-mm group) moved away. In addition, one patient in the 6-mm group lost one implant and no implants were lost in the 11-mm group. Two patients lost three restorations in the 6-mm group and no restorations were lost in the 11-mm group. From loading until the 60-month assessment, the mean marginal bone loss in the 6-mm group and the 11-mm group was 0.12 ± 0.36 mm and 0.14 ± 0.63 mm, respectively, without a significant difference (mean difference 0.02 mm; 95% CI -0.32 to 0.37; P = 0.884). Implant loss, restoration loss, screw loosening and porcelain chipping were defined as complications. Four patients in the 6-mm group and one patient in the 11-mm group had one or more complications, without a significant difference between the groups (95% CI 0.019 to 0.244; P = 0.198). The patient satisfaction was high in both groups (mean overall satisfaction in the 6-mm and the 11-mm groups was 9.4 ± 0.8 and 9.2 ± 0.8, ...
Results: One patient (11-mm group) died before the 12-month evaluation and one patient (6-mm group) moved away. In addition, one patient in the 6-mm group lost one implant and no implants were lost in the 11-mm group. Two patients lost three restorations in the 6-mm group and no restorations were lost in the 11-mm group. From loading until the 60-month assessment, the mean marginal bone loss in the 6-mm group and the 11-mm group was 0.12 ± 0.36 mm and 0.14 ± 0.63 mm, respectively, without a significant difference (mean difference 0.02 mm; 95% CI -0.32 to 0.37; P = 0.884). Implant loss, restoration loss, screw loosening and porcelain chipping were defined as complications. Four patients in the 6-mm group and one patient in the 11-mm group had one or more complications, without a significant difference between the groups (95% CI 0.019 to 0.244; P = 0.198). The patient satisfaction was high in both groups (mean overall satisfaction in the 6-mm and the 11-mm groups was 9.4 ± 0.8 and 9.2 ± 0.8, ...
Cimetidine is a powerful H2 receptor antagonist originally designed to treat ulcers by blocking the acid producing cells in the stomach. In the study three groups of rabbits were simultaneously induced with experimental periodontitis using P. gingivalis and treated with varying levels of topically applied cimetidine three times a week over a six-week period. Results showed that topical application of cimetidine at all concentrations inhibited inflammation and bone loss by approximately 90 ...
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