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TY - JOUR. T1 - Suppression of monocyte chemoattractant protein 1, but not IL-8, by alprazolam. T2 - Effect of alprazolam on c-Rel/p65 and c-Rel/p50 binding to the monocyte chemoattractant protein 1 promoter region. AU - Oda, Taiko. AU - Ueda, Atsuhisa. AU - Shimizu, Noriaki. AU - Handa, Hiroshi. AU - Kasahara, Tadashi. PY - 2002/9/15. Y1 - 2002/9/15. N2 - Alprazolam is a hypnotic/tranquilizer that has been shown to specifically inhibit the platelet-activating factor (PAF)-induced aggregation of human platelets. The goal of this study was to elucidate whether alprazolam modulates IL-1α-initiated responses. For this purpose we investigated the effects of alprazolam on the IL-1α-induced production of inflammatory cytokines (IL-8 and monocyte chemoattractant protein 1 (MCP-1)) in a human glioblastoma cell line, T98G, and explored the signaling pathways involved. We found that alprazolam inhibited IL-1α-elicited MCP-1 production within a range of 0.1-3 μM. In contrast, it did not inhibit ...
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AIMS: To describe alprazolam poisoning and the relative toxicity of alprazolam compared with other benzodiazepines. METHODS: A database of consecutive poisoning admissions to a regional toxicology service was searched to identify consecutive benzodiazepine deliberate self poisonings, which were coded as alprazolam, diazepam or other benzodiazepine. Major outcomes used were length of stay (LOS), intensive care (ICU) admission, coma (GCS > 9), flumazenil administration and requirement for mechanical ventilation. Prescription data were obtained for benzodiazepines for the study period. RESULTS: There were 2063 single benzodiazepine overdose admissions: 131 alprazolam overdoses, 823 diazepam overdoses and 1109 other benzodiazepine overdoses. The median LOS for alprazolam overdoses was 19 h which was 1.27 (95% CI 1.04, 1.54) times longer compared with other benzodiazepines by multiple linear regression. For patients with alprazolam overdoses, 22% were admitted to ICU which was 2.06 (95% CI 1.27, ...
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Alprazolam is a benzodiazepine (ben-zoe-dye-AZE-eh-peen). Alprazolam affects chemicals in the brain that may be unbalanced in people with anxiety. Alprazolam is used to treat anxiety disorders, panic disorders, and anxiety caused by depression. Alprazolam may also be used for purposes not listed in this medication guide.
Certain adverse clinical events, some life-threatening, are a direct consequence of physical dependence to alprazolam. These include a spectrum of withdrawal symptoms; the most important is seizure (see DRUG ABUSE AND DEPENDENCE). Even after relatively short-term use at doses of less than or equal to 4 mg/day, there is some risk of dependence. Spontaneous reporting system data suggest that the risk of dependence and its severity appear to be greater in patients treated with doses greater than 4 mg/day and for long periods (more than 12 weeks). However, in a controlled postmarketing discontinuation study of panic disorder patients who received alprazolam tablets, the duration of treatment (3 months compared to 6 months) had no effect on the ability of patients to taper to zero dose. In contrast, patients treated with doses of alprazolam tablets greater than 4 mg/day had more difficulty tapering to zero dose than those treated with less than 4 mg/day.. Relapse or return of illness was defined as a ...
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EuroBolic.com: Alprazolam, also known under the trade names Xanax, Xanor and Niravam, is a short-acting drug of the benzodiazepine class used to treat moderate to severe anxiety disorders, panic attacks, and is used as an adjunctive treatment for anxiety associated with moderate depression. Alprazolam is also available in an extended-release form, Xanax XR, both of which are now available in generic form. Alprazolam possesses anxiolytic, sedative, hypnotic, anticonvulsant, and muscle relaxant properties.
A powerful anti-anxiety drug has been involved in a rising number of heroin-related deaths (HRDs) in Victoria in recent years, according to new research.. In a paper published in the Medical Journal of Australia today, researchers from Monash University called for the prescription and scheduling of the benzodiazepine alprazolam to be examined, after their study uncovered a dramatic increase in the supply of this drug, and detection in a rising rate of HRDs.. The findings come weeks before the Therapeutic Goods Association is due to meet to discuss whether more restrictions should be placed on the availability of benzodiazepines.. Alprazolam is a psychoactive drug approved for the short-term treatment of anxiety and panic disorder in Australia. Alprazolam is not recommended as a firstline treatment for these conditions due to concern about dependence, the potential for its misuse and because non-pharmaceutical interventions, such as cognitive behavioural therapy, have been found to be more ...
How to Withdraw from Alprazolam. Alprazolam, or Xanax (brand name), is a medication known as a benzodiazepine that is used to treat anxiety disorders, panic attacks and other related psychiatric disorders. Alprazolam and other...
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ALP Alprazolam is a drug of Anti-Anxiety category. You can see details and related ALP Alprazolam in same (condition) category written below.. Anti-Anxiety:. The unpleasant emotional state consisting of psychophysiological responses to anticipation of unreal or imagined danger, ostensibly resulting from unrecognised intrapsychic conflict.. Physiological concomitants include increased heart rate, altered respiration rate, sweating, trembling, weakness and fatigue, psychological concomitants include feelings of impending danger, powerlessness, apprehension and tension.. Want Anti-Anxiety medication? You can buy ALP Alprazolam online here.. Many different types of medications are used in the treatment of anxiety disorders, including traditional anti-anxiety drugs such as benzodiazepines, and newer options like antidepressants and beta-blockers.. ...
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Alprazolam is recognized for its immediate side effects which can take 30 minutes and last for about 6 hours. This characteristic can effectively help people suffering from panic disorders and anxiety as it can quickly act on the central nervous system.. When users take more than prescribed or intentionally consume alprazolam for recreational use they will experience the short-term effects of the drug. These include the feeling of euphoria and act worry free. If taken in higher doses, the drug can cause lapses in memory.. Similarly abusing alprazolam can cause numerous detrimental side effects to the body.. ...
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Because the management of panic disorder often requires the use of average daily doses of alprazolam above 4 mg, the risk of dependence among panic disorder patients may be higher than that among those treated for less severe anxiety. Experience in randomized placebo-controlled discontinuation studies of patients with panic disorder showed a high rate of rebound and withdrawal symptoms in patients treated with alprazolam compared to placebo-treated patients.. Relapse or return of illness was defined as a return of symptoms characteristic of panic disorder (primarily panic attacks) to levels approximately equal to those seen at baseline before active treatment was initiated. Rebound refers to a return of symptoms of panic disorder to a level substantially greater in frequency, or more severe in intensity than seen at baseline. Withdrawal symptoms were identified as those which were generally not characteristic of panic disorder and which occurred for the first time more frequently during ...
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Onset: Alprazolam IR : 8-25 minutes Alprazolam XR : 25-75 minutes Diazepam : Rapid Clonazapam : 1 hour Lorazepam : 1-2 hours Peak Benefit: Diazepam: 1.6 hours Alprazolam IR : 90 minutes Alprazolam XR : 25-75 minutes Diazepam : 2-4 hours Clonazapam: 1-4 hours Half/Life and Duration Triazolam: 2.5 Hours Lorazepam: 10-20 hours - 6-12 hour duration Alprazolam IR : 11 hour half life - 5 hour duration Alprazolam XR :11-16 hour hour half life, 11 hour duration Diazepam : 20-100 hour half life - 6-8 hour duration Clonazepam: 18-50 hour half life - 12+ hours Dosages Depend on tolerance. Potentiators: -Grapefruit juice Avoid: -Excessive drinking (you will die) ...
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