The molecular basis of the deficiency of alpha-L-fucosidase has been investigated in eight patients who had been diagnosed clinically and enzymatically as suffering from the autosomal recessive lysosomal storage disease fucosidosis. None of the patients had a deletion or gross alteration of the alpha-L-fucosidase gene (FUCA1). Single strand conformation polymorphism (SSCP) analysis followed by direct sequencing of amplified exons and flanking regions identified putative disease causing mutations in six of the patients, who had severe forms of the disease and very low residual alpha-L-fucosidase activity and protein. They were a 10 bp deletion in exon 1 (E113fs), a 1 bp deletion at position -2 of intron 2 (S216fs), a g--,a transition at IVS5+1, point mutations W183X and N329Y in exons 3 and 6, respectively, and a compound allele consisting of a point mutation in the signal peptide in exon 1, P5R, and a 1 bp insertion in exon 6 (Y330fs). One patient in whom an SSCP change was not detected had ...

Severe progressive fatal neurological degeneration occurs in fucosidosis, a storage disease. Bone marrow transplantation into affected dogs has shown that haematopoietic stem cells can provide enzyme producing daughter cells to the central nervous system, altering disease course. This makes canine fucosidosis an ideal large animal model for gene therapy. Fucosidosis affected allogeneic or autologous canine marrow was transduced ex vivo by cocultivation, then transplanted into fucosidosis affected dogs conditioned with total lymphoid irradiation. The vectors were Moloney murine leukaemia virus based. Transduction efficiency was increased with multiple cytokines in short term marrow culture. Despite high levels of transduction, proviral sequence was detected 2 months post transplant in only one dog. Early or total graft failure occurred in all transplants. We believe lack of engraftment could be caused by differentiation or change of repopulating ability of marrow cells occurring with multiple ...

The desire for improved methods of biomass conversion into fuels and feedstocks has re-awakened interest in the enzymology of plant cell wall degradation. The complex polysaccharide xyloglucan is abundant in plant matter, where it may account for up to 20% of the total primary cell wall carbohydrates. Despite this, few studies have focused on xyloglucan saccharification, which requires a consortium of enzymes including endo-xyloglucanases, alpha-xylosidases, beta-galactosidases and alpha-L-fucosidases, among others. In the present paper, we show the characterization of Xy131A, a key alpha-xylosidase in xyloglucan utilization by the model Gram-negative soil saprophyte Cellvibrio japonicus. CjXy131A exhibits high regiospecificity for the hydrolysis of XGOs (xylogluco-oligosaccharides), with a particular preference for longer substrates. Crystallographic structures of both the apo enzyme and the trapped covalent 5-fluoro-beta-xylosyl-enzyme intermediate, together with docking studies with the XXXG ...

Fucosidosis is a rare lysosomal storage disorder caused by the inherited deficiency of the lysosomal hydrolase α-L-fucosidase, which leads to an impaired degradation of fucosylated glycoconjugates. Here we report the generation of a fucosidosis mouse model, in which the gene for lysosomal α-L-fucosidase (Fuca1) was disrupted by gene targeting. Homozygous knock-out mice completely lack α-L-fucosidase activity in all tested organs leading to highly elevated amounts of the core-fucosylated glycoasparagine Fuc(α1,6)-GlcNAc(β1-N)-Asn and, to a lesser extent, other fucosylated glycoasparagines, which all were also partially excreted with the urine. Lysosomal storage pathology was observed in many visceral organs like liver, kidney, spleen and bladder as well as in the CNS. On the cellular level storage was characterized by membrane-limited cytoplasmic vacuoles primarily containing water-soluble storage material. In the CNS cellular alterations included enlargement of the lysosomal compartment in ...

Gauthami S. Kondagari, Barbara M. King, Peter C. Thomson, Peter Williamson, Peter R. Clements, Maria Fuller, Kim M. Hemsley, John J. Hopwood, Rosanne M. Taylor ...

Several 2-(aminomethyl)-and 2-(2-aminoethyl)-pyrrolidine-3,4-diol derivatives have been assayed for their inhibitory activities towards glycosidases. Good inhibitors of alpha-mannosidases must have the (2R,3R,4S) configuration and possess 2-(benzylamino)methyl substituents. Stereomers with the (2S,3R,4S) configuration are also competitive inhibitors of alpha-mannosidases, but less potent as they share the configuration of C(1), C(2), C(3) Of beta-D-mannosides rather than that Of alpha-D-mannosides. Interestingly, (2S,3R,4S)-2-{2-[(4-phenyl)phenylamino]ethyl}pyrrolidine-3,4-diol (12g) inhibits several enzymes, for instance alpha-L-fucosidase from bovine epididymis (K-i = 6.5 muM, competitive), alpha-galactosidase from bovine liver (K-i = 5 muM, mixed) and alpha-mannosidase from jack bean (K-i = 102 muM, mixed). Diamines such as (2R,3S,4R)-2-[2-(phenylamino) or 2-(benzylamino)ethyl]pyrrolidine-3,4-diol (ent-1 2a, ent-12b) inhibit P-glucosidase from almonds (K-i = 13-40 muM, competitive). (C) 2003 Elsevier

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InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites. We combine protein signatures from a number of member databases into a single searchable resource, capitalising on their individual strengths to produce a powerful integrated database and diagnostic tool.

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Expression of FUCA2 (dJ20N2.5, MGC1314) in caudate tissue. Antibody staining with HPA031659, HPA031660 and HPA031661 in immunohistochemistry.

chains in the Genus database with same CATH superfamily 1J2Z A; 2OEG A; 1XAT A; 3SPT A; 2ICY A; 3GUE A; 3MQG A; 4E6T A; 5ADX U; 3OW5 A; 4MYO A; 3TDT A; 3VBI A; 3JQY A; 4EA9 A; 4G3S A; 2FKO A; 5ADX V; 4H7O A; 3MQH A; 4E1K A; 1OCX A; 2IU9 A; 3VBM A; 3NZ2 A; 4J09 A; 3FSB A; 2I5K A; 5E3Q A; 5L6S A; 4EAA A; 3F1X A; 3IGJ A; 3R1W A; 4KQL A; 1KGQ A; 2JF2 A; 3BSS A; 3FTT A; 3BRK X; 1QQ0 A; 3CJ8 A; 4HZC A; 5E3P A; 3BSW A; 2WLE A; 4G3P A; 1KQA A; 3R5A A; 4N6A A; 5AFU U; 2IUA A; 3P1B A; 5U2K A; 4EQY A; 4DCL A; 3OTM A; 2TDT A; 3OTZ A; 5E3R A; 3FWW A; 5AFU V; 1HM0 A; 3OUP A; 3FOQ A; 2OEF A; 2WLD A; 3R5C A; 1HM9 A; 1YP3 A; 2QIA A; 4IHF A; 4IHG A; 3VBK A; 3VBN A; 4ISX A; 1KRV A; 4AAW A; 3R8Y A; 3GOS A; 3VBP A; 3KWE A; 4KNX A; 1QRE A; 2V0K A; 3DHO A; 3D98 A; 2OI6 A; 3R0S A; 4HUS A; 2V0H A; 1TDT A; 4KNR A; 4M2A A; 4EGG A; 1FWY A; 3D8V A; 3BFP A; 4E75 A; 3EG4 A; 1YP4 A; 2JF3 A; 4M99 A; 1MR7 A; 3MC4 A; 2WLG A; 1V67 A; 3TIS A; 2RIJ A; 3EH0 A; 3FS8 A; 4AC3 A; 1MR9 A; 2XAT A; 3TIO A; 1LXA A; 4EA8 A; 1V3W A; 3SRT A; ...

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chains in the Genus database with same CATH superfamily 4EGG A; 4G3P A; 4EA9 A; 1TDT A; 1YP2 A; 1SSM A; 4HUS A; 3BSY A; 2V0H A; 3VBJ A; 3HSQ A; 1KK5 A; 2OEG A; 3R5D A; 2QKX A; 4IHH A; 3DHO A; 1HV9 A; 4KPZ A; 4G3Q A; 2AQ9 A; 2V0I A; 3V4E A; 5L6V A; 4N27 A; 4E75 A; 3FSY A; 3R3R A; 3P1B A; 2WLE A; 4MZU A; 4EA7 A; 2IU9 A; 3VBN A; 3R1W A; 3GOS A; 4EAA A; 2V0J A; 3SPT A; 1XHD A; 3VBK A; 3VNP A; 4M28 A; 2WLD A; 1QRF A; 2IU8 A; 4EAB A; 5F42 A; 5E3R A; 4J18 A; 3FSB A; 4E79 A; 3I3A A; 2V0L A; 1V3W A; 4N6A A; 2GGO A; 3ST8 A; 4E6U A; 5ADX U; 3EG4 A; 1SSQ A; 4KNX A; 3TK8 A; 1T3D A; 3BRK X; 2QIV X; 2NPO A; 3EH0 A; 3F1X A; 2XAT A; 4R7P A; 4M2B A; 4IHF A; 2WLG A; 3HJJ A; 4AA7 A; 3CJ8 A; 3BXY A; 2RIJ A; 3FSC A; 3KWD A; 2W0W A; 3ECT A; 2P2O A; 2OI6 A; 4KPX A; 4HZD A; 5DEM A; 5AFU V; 1MR7 A; 3FTT A; 3NZ2 A; 1G97 A; 1MR9 A; 3OU9 A; 1KHR A; 3BSW A; 1MRL A; 1OCX A; 3IGJ A; 3OTM A; 4MFG A; 3VBM A; 3T57 A; 2W0V A; 3R5A A; 2VHE A; 2OEF A; 2OI7 A; 3I3X A; 2Q4J A; 1KRR A; 1KGT A; 1Z90 A; 3VBI A; 1QRM A; 3C8V A; 2IC7 A; ...

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At least 26 mutations in the FUCA1 gene have been found to cause fucosidosis. Most of these mutations result in an abnormally short, nonfunctional alpha-L-fucosidase enzyme. Without this enzyme, glycolipids and glycoproteins cannot be completely broken down. These partially broken down compounds accumulate in the lysosomes and cause cells throughout the body to malfunction. Brain cells are particularly sensitive to the buildup of glycolipids and glycoproteins, which can result in cell death. Loss of brain cells is thought to cause the neurological symptoms of fucosidosis. Accumulation of glycolipids and glycoproteins also occurs in other organs such as the liver, spleen, skin, heart, pancreas, and kidneys, contributing to the additional symptoms of fucosidosis. ...

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Önenli-Mungan N, Özer G, Altunbaşak Ş, Besley G, Yüksel B, Topaloğlu AK, Soyupak S. Fucosidosis with hypothyroidism: a case report. Turk J Pediatr 2004; 46: 170-173.. Fucosidosis is a rare, autosomal recessive lysosomal storage disorder caused by a severe deficiency of [alpha]-L-fucosidase.. Here we present a 27-month-old male who was referred to us for evaluation of developmental delay, which was first detected at age six months. His past medical history was also remarkable for recurrent pulmonary infections and myoclonic seiures. His family history revealed that he was the first living child from a consanguineous marriage. He had a younger sister who died at five months of age from pneumonia who had facial resemblance to the proband, developmental delay and a congenital heart defect.. Physical examination revealed length: 81 cm (25-50p), weight: 10.2 kg (25-50p), and head circumference: 49 cm (50-75p). He had a coarse face, hepatomegaly and generalized spasticity.. His initial laboratory ...

Background: Some salivary markers of alcohol abuse/dependence have been proposed so far: aminotransferases, gamma-glutamyltransferase, ethanol, ethyl glucuronide, ethyl sulfate, sialic acid, β-hexosaminidase A, oral peroxidase, methanol, diethylene/ethylene glycol, α-amylase, clusterin, haptoglobin, heavy/light chains of immunoglobulins and transferrin. Aim: To investigate the effect of chronic alcohol drinking and smoking on the activity (pKat/ml) and output (pKat/min) of salivary lysosomal exoglycosidases: α-fucosidase (FUC), α-mannosidase (MAN), β-galactosidase (GAL), and β-glucuronidase (GLU), and their applicability as markers of alcohol dependence. Methods: The activity of FUC, MAN, GAL and GLU was measured colorimetrically in the saliva of healthy social drinkers, alcohol-dependent non-smokers and alcohol-dependent smokers. Results: We observed an increased salivary activity of FUC, GAL, GLU and MAN, as well as an increased output of GAL and GLU, in comparison with controls. The ...

Catheter ablation of atrial fibrillation (AFCA) efficacy in patients with impaired left ventricular systolic function improves when performed early in the natural history of atrial fibrillation (AF) and heart failure, according to a study published recently in Circulation: Arrhythmia and Electrophysiology.1 AFCA provides long-term benefits on left ventricular function, significantly reducing the number of patients with severely impaired systolic function, the authors add. ...

Expression of FUCA2 (dJ20N2.5, MGC1314) in endometrium tissue. Antibody staining with HPA031659 and HPA031661 in immunohistochemistry.

A friend of mine raised some concerns on her blog about Bill 106 - The Safer Communities and Neighbourhoods Act, which was recently introduced into the Ontario Legislature as a private members Bill by Ottawa Centre Liberal MPP Yasir Naqvi. This post is an extension of the comments I left as responses to her post.…

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Sperm-associated antigen 8 is a protein that in humans is encoded by the SPAG8 gene. The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein encoded by this gene is recognized by sperm agglutinating antibodies from an infertile woman. This protein is localized in germ cells of the testis at all stages of spermatogenesis and is localized to the acrosomal region of mature spermatozoa. Alternatively spliced variants that encode different protein isoforms have been described but the full-length sequences of only two have been determined. GRCh38: Ensembl release 89: ENSG00000137098 - Ensembl, May 2017 GRCm38: Ensembl release 89: ENSMUSG00000066196 - Ensembl, May 2017 Human PubMed Reference:. ...

Domain architecture and assignment details (superfamily, family, region, evalue) for Afu5g13040 from Aspergillus fumigatus Af293. Plus protein sequence and external database links.

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Plasminogen, the proenzyme of the fibrinolytically active enzyme plasmin, is a single chain glycoprotein with a molecular weight of about 90,000-94,000 Da (2). Various isoelectric forms exist and can be separated by means of isoelectric focusing (IEF).

According to the medical personnel of the AFU units (Ukrainian troops) there were recorded mass diseases among the Ukrainian military personnel in the field. Physicians recorded the unknown virus as a result of which the infected get the high fever which cannot be subdues by any medicines, and in two days there comes the fatal outcome. Thus far from the virus there have died more than twenty servicemen, what is carefully shielded by the commandment of the AFU from the publicity, said Basurin in daily MoD situation report ...

Ten Essential Facts Aboot Canada: 01) Our Origins Are Cloaked In Mystery Confusion: The Dominion Of Canada was created in 1867, Newfoundland joined up in 1949. We got our own flag in 1967 1965 (oops), and our own Constitution and Charter Of Rights And Freedoms in 1982. The Canadian Province of Quebec, with a population…

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Toshiba has begun shipping a 14TB helium-filled hard drive to clients, its largest capacity to date and the company's first foray into helium territory. Of course, helium-filled HDDs are not new, and WD already released a 14TB HDD a couple of months ago. However, Toshiba's is the industry's first HDD to pack nine disks inside, and the only 14TB drive to use conventional magnetic recording (CMR) technology.The new drive is part of Toshiba's MG07ACA series. It is available in both 12TB and 14TB capacities, both of which are CMR drives.We have raised the bar with the new MG07ACA Series 9-disk helium-sealed design, said Akitoshi Iwata, Vice President of Storage Products Division, Toshiba Electronic Devices and Storage Corporation. By utilizing an innovative design, we continue to improve the benefits that high-capacity disk storage can deliver to our broad global customer base.There are a couple of things to note about the 14TB model that make it sta

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Tesla has begun mass production of a new battery cell that will be used in Teslas energy storage products and upcoming Model 3 at its Nevada-based Gigafactory.

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TY - JOUR. T1 - Lysosomal dysfunction causes neurodegeneration in mucolipidosis II knock-in mice. AU - Kollmann, K.. AU - Damme, M.. AU - Markmann, S.. AU - Morelle, W.. AU - Schweizer, M.. AU - Hermans-Borgmeyer, I.. AU - Röchert, A. K.. AU - Pohl, S.. AU - Lübke, T.. AU - Michalski, J. C.. AU - Käkelä, R.. AU - Walkley, S. U.. AU - Braulke, T.. PY - 2012/9. Y1 - 2012/9. N2 - Mucolipidosis II is a neurometabolic lysosomal trafficking disorder of infancy caused by loss of mannose 6-phosphate targeting signals on lysosomal proteins, leading to lysosomal dysfunction and accumulation of non-degraded material. However, the identity of storage material and mechanisms of neurodegeneration in mucolipidosis II are unknown. We have generated knock-in mice with a common mucolipidosis II patient mutation that show growth retardation, progressive brain atrophy, skeletal abnormalities, elevated lysosomal enzyme activities in serum, lysosomal storage in fibroblasts and brain and premature death, ...

The coarse facial features have been described as Hurler-like. Two major types have been described: type 1 with onset in the first 6 months of life and rapid psychomotor and general neurologic deterioration, and the later onset, less severe type 2 in which angiokeratomas resembling Fabry disease occur. Infants with type 1 may not survive beyond one year of age. The Hurler-like face is less pronounced and the neurologic deterioration is less rapid in type 2 with survival often into the third decade or later. The intracellular accumulation of glycolipids and glycoproteins leads to cell death accounting for the progression of CNS disease. Abnormal bone growth (dysostosis multiplex) can lead to short stature. Elevated sweat NaCl, hypohidrosis, and poor temperature control can be a feature of both types but this is more pronounced in type 1. The DNA mutation is the same in both types and there may be overlap in some of the clinical features. Furthermore, both types have been reported in the same ...

Mucopolysaccharidosis like inherited storage disorders. Four have been identified so far: muramidase deficiency (ML I), I cell disease (ML II), pseudo Hurler polydystrophy (ML III), and sialicosis (ML IV, also called fucosidosis). Abbreviated ML

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Calcium ions play a primary role in the regulation of sperm motility. This gene belongs to a family of putative cation channels that are specific to spermatozoa and localize to the flagellum. The protein family features a single repeat with six membrane-spanning segments and a predicted calcium-selective pore region. This gene is part of a tandem repeat on chromosome 15q15; the second copy of this gene is thought to be a pseudogene. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2014 ...

Mucolipidosis II (I-cell disease) and mucolipidosis IIIA (classical pseudo-hurler polydystrophy) are caused by mutations in the GlcNAc-phosphotransferase alpha / beta -subunits precursor gene. Kudo M, Brem MS, Canfield WM Am J Hum Genet. 2006 Mar;78(3):451-63. For more information on Mucolipidosis II and mucolipidosis IIIA, please visit OMMBID Chapter 138. Thank you very much in advance […]. ...

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