The molecular chaperone alphaB-crystallin has emerged as a target for cancer therapy due to its expression in human tumors and its role in regulating tumor angiogenesis. alphaB-crystallin also reduces neuroinflammation, but its role in other inflammatory conditions has not been investigated. Here, we examined whether alphaB-crystallin regulates inflammation associated with tumors and ischemia. We found that CD45(+) leukocyte infiltration is 3-fold increased in tumors and ischemic myocardium in alphaB-crystallin-deficient mice. Notably, alphaB-crystallin is prominently expressed in CD11b(+) Gr-1(+) immature myeloid cells (IMCs), known as regulators of angiogenesis and immune responses, while lymphocytes and mature granulocytes show low alphaB-crystallin expression. alphaB-Crystallin deficiency results in a 3-fold higher accumulation of CD11b(+) Gr-1(+) IMCs in tumors and a significant rise in CD11b(+) Gr-1(+) IMCs in spleen and bone marrow. Similarly, we noted a 2-fold increase in CD11b(+) ...
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Desmin-related myopathy is a subgroup of myofibrillar myopathy caused by mutations in desmin, CryAB, and other proteins that interact with the intermediate filaments. The pathology is characterized by myofibril disruption that appears to initiate at the Z-disk. Dislocation and aggregation of membranous organelles is observed as well as the accumulation of the mutant, misfolded desmin, and/or CryAB into insoluble aggregates, which gradually increase in the cytoplasm and are thought to eventually result in cell death.1-3 We previously showed that these aggregates may be classified as aggresomes, whose accumulation is often associated with neurodegenerative diseases caused by protein misfolding or unfolding.8 Our studies showed that the aggresomes present in the cardiomyocytes contain large concentrations of a toxic amyloid oligomer, which is typically found in many of the amyloid-based neurodegenerative diseases. The data thus link these cardiomyopathies to a broad class of amyloid-based ...
Desmin-related cardiomyopathy (DRC) belongs to the family of myofibrillar diseases characterized by the presence of toxic desmin-positive aggregates and degeneration at Z-disk structures. DRC has been linked to the mutations in the desmin, αBcrystallin (CryAB), or myotilin genes. Several human CryAB mutations cause multisystem disorders and experimental models of R120GCryAB in transgenic mice strikingly recapitulate similar phenotype observed in patients. In this context, we have generated the 450delACryAB linked to inheritable cataracts in neonatal rat cardiomyocytes and mice hearts. 450delACryAB formed aggregates or aggresomes, and recruited HSP25 into the insoluble fraction in the cardiomyocytes. However, heart-specific 450delA CryAB overexpression neither causes desmin-related cardiomyopathy nor exacerbates pressure overload-induced hypertrophy. To our knowledge, this is the first report of compensation to protein aggregates formation abrogates the development of cardiomyopathy and suggests ...
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TY - JOUR. T1 - Matrix metalloproteinase-1 induces cleavage of exogenous alphab-crystallin transduced by a cell-penetrating peptide. AU - Yang, Seung Won. AU - Lee, Seung Min. AU - Choi, Eun Young. AU - Lee, Kyung Hye. AU - Kim, Soo Hyuk. AU - Shin, Min Jeong. AU - Han, Ye Sun. AU - Kang, Seok Min. AU - Chung, Ji Hyung. PY - 2011/9/1. Y1 - 2011/9/1. N2 - Cell-penetrating peptides (CPPs), including TAT-CPP, have been used to deliver exogenous proteins into living cells. Although a number of proteins fused to TAT-CPP can be delivered into various cells, little is known about the proteolytic cleavage of TAT-fusion proteins in cells. In this study, we demonstrate that a small heat shock protein (sHSP), alphaB-crystallin (αB-crystallin), delivered by TAT-CPP is susceptible to proteolytic cleavage by matrix metalloproteinase-1 (MMP-1) in cardiac myoblast H9c2 cells. Recombinant TAT-αB-crystallin was efficiently transduced into H9c2 cells. For a few hours following protein transduction, generation of ...
Not surprisingly, the body can also suffer from reductive stress which frequently goes unmentioned. Reductive stress is achieved when the concentrations of reducing agents exceeds that of oxidizing agents. This is commonly encountered with the metabolism of ethanol. It is therefore possible for "Health Fanatics" to overdose on anti-oxidants and push the body into reductive stress instead of the oxidative stress they are steadfastly trying to avoid. Exercise can have positive or negative effects with regard to Redox effects on the body according to how it is performed. Exercise increases oxidative stress due to metabolic processes but when exercise is undertaken on a regular basis the body up-regulates its own anti-oxidant capacity to cope with the increased demand. This improved anti-oxidant activity clearly has additional benefits when we are not exercising but are under oxidative stress in other ways. Intermittent exercise will increase the oxidative stress burden on the body but is not ...
Accordingly, its important to look beyond the ostensibly obvious results like "low AGE diets promote fat and weight loss". While this may be true, even the cursory analysis of the study results in todays SuppVersity short news indicates that the obvious conclusion that reducing AGEs would mechanistically reduce body fat is probably flawed. Rather than that people who avoid high AGE foods will necessary avoid foods with high energy density, consume less energy and lose weight in response to a reduction in energy intake - not in response to the reduced intake of AGEs. Problems like these are why it is important to look beyond the conclusions in the abstracts and / or come back to the SuppVersity regularly for short and in-depth analyses of the latest studies , Comment on Facebook ...
Jeffrey Rosenthal - Jeffrey Rosenthal earned his PhD in mathematics from Harvard at just 24 years old. From there, he became a professor in the department of statistic...
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Learn about Alexander Disease and other health conditions at HealtheTreatment. What is Alexander Disease? Compare Alexander Disease symptoms Alexander Disease treatments and . Share online in the health community.
TY - JOUR. T1 - P62 Stages an Interplay Between the Ubiquitin-Proteasome System and Autophagy in the Heart of Defense Against Proteotoxic Stress. AU - Su, Huabo. AU - Wang, Xuejun. PY - 2011/11/1. Y1 - 2011/11/1. N2 - As exemplified by desmin-related cardiomyopathy and myocardial ischemia/reperfusion injury, proteasome functional insufficiency plays an essential pathogenic role in the progression of cardiac diseases with elevated proteotoxic stress. Upregulation of p62/SQSTM1 and increased selective autophagy in cardiomyocytes may protect against proteotoxic stress in the heart. p62 may serve as a proteotoxic stress sensor, promote segregation and degradation of misfolded proteins by autophagy, and mediate the cross talk between the ubiquitin-proteasome system and autophagy.. AB - As exemplified by desmin-related cardiomyopathy and myocardial ischemia/reperfusion injury, proteasome functional insufficiency plays an essential pathogenic role in the progression of cardiac diseases with elevated ...
Alpha-crystallin B chain is a protein that in humans is encoded by the CRYAB gene. It is part of the small heat shock protein family and functions as molecular chaperone that primarily binds misfolded proteins to prevent protein aggregation, as well as inhibit apoptosis and contribute to intracellular architecture. Post-translational modifications decrease the ability to chaperone. Defects in this gene/protein have been associated with cancer and neurodegenerative diseases such as Alzheimers disease and Parkinsons disease. Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and ...
Alexander disease is a leukodystrophy, a group of more than 15 rare genetic disorders that cause progressive degeneration of the white matter of the brain due…
BACKGROUND: We studied a family including two half-siblings, sharing the same mother, affected by slowly progressive, adult-onset neurological syndromes. In spite of the diversity of the clinical features, characterized by a mild movement disorder with cognitive impairment in the elder patient, and severe motor-neuron disease (MND) in her half-brother, the brain Magnetic Resonance Imaging (MRI) features were compatible with adult-onset Alexanders disease (AOAD), suggesting different expression of the same, genetically determined, condition.METHODS: Since mutations in the alpha isoform of glial fibrillary acidic protein, GFAP-α, the only cause so far known of AOAD, were excluded, we applied exome Next Generation Sequencing (NGS) to identify gene variants, which were then functionally validated by molecular characterization of recombinant and patient-derived cells.RESULTS: Exome-NGS revealed a mutation in a previously neglected GFAP isoform, GFAP-ϵ, which disrupts the GFAP-associated ...
Alexander disease, a Leukodystrophy, is a progressive and fatal neurological disorder in which the destruction of white matter in the brain is accompanied by the formation of abnormal deposits known as Rosenthal fibers. Rosenthal fibers are aggregations of protein that occur in astrocytes, one of the so-called "glial" cells of the central nervous system. These aggregates are found occasionally in other disorders, but not with the abundance or particular distribution in the brain that occurs in Alexander disease.. The age of onset is quite variable, ranging from prenatal through the sixth decade. The most common classification divides patients into three categories based on age of onset, infantile (0-2 years), juvenile (2-12 years), and adult (,12 years). More recently, a different classification has been proposed, with only two categories of type I and type II, with the distinction hinging more on distribution of lesions and clinical presentation rather than age of onset (all type I cases being ...
A representation of NAD showing the change that occurs in the nicotinamide moiety (encircled) when NAD+ is reduced to NADH. In NAD+, the nicotinamide moiety has a planar structure, whereas it is puckered in NADH as shown in this animation (avi).. In facultative aerobic bacteria the catabolism of fuel molecules is associated with the reduction of NAD+ to NADH. During the transition to oxygen limited growth, an increased level of NADH builds up, as it is less efficiently reoxidized to NAD+ as a result of reduced aerobic respiration. These roles of NADH and NAD+ provide a link between energy homeostasis and gene regulation. In most Gram-positive bacteria a novel sensor of the NAD redox balance is present. This transcriptional repressor is called Rex (from redox; Figure 2). Transcription of Rex-repressed genes in Bacillus subtilis is activated when oxygen is limiting for aerobic respiration, and as a consequence the levels of free NADH increase. This leads to production of cytochrome bd (a ...
α-Crystallin is the principal lens protein which, in addition to its structural role, also acts as a molecular chaperone, to prevent aggregation and precipitation of other lens proteins. One of its two subunits, αB-crystallin, is also expressed in many non-lenticular tissues, and a natural missense mutation, R120G, has been associated with cataract and desminrelated myopathy, a disorder of skeletal muscles (Vicart et al., 1998, Nature Genet. 20:92-95). In the present study, real-time 1H NMR spectroscopy showed that the ability of R120G αB-crystallin to stabilize the partially folded, molten globule state of α- lactalbumin was significantly reduced in comparison with wild type αB-crystallin. The mutant showed enhanced interaction with, and promoted unfolding of reduced α- lactalbumin, while it showed limited chaperone activity for other target proteins. Using NMR spectroscopy, gel electrophoresis and mass spectrometry (MS) it was observed that, unlike the wild type protein, R120G αB-crystallin is
See the Rosenthal surname, family crest & coat of arms. Free Search. Uncover the Rosenthal surname history for the German Origin. What is the history of the last name Rosenthal?
ATGen operates in the Commercial Physical Research sector. ATGen is a Korea-based company principally engaged in developing and manufacturing reagent used for experimentation . The Companys product portfolio consists of recombination proteins including binding immunoglobulin protein, carboxy terminus of HSP70 interacting protein, BCL2-associated athanogene 2; monoclonal antibodies including 14-3-3 beta antibody, A crystallin A antibody , alpha-crystallin B and NK Vue Kit used for physical examination and diagnosis. The Company distributes its products within domestic market and to overseas markets.
The Rosenthal Malibu winery holds a variety of year-round Malibu wine tasting events. We offer special VIP access for members and a variety of wines online.
The Rosenthal Malibu winery holds a variety of year-round Malibu wine tasting events. We offer special VIP access for members and a variety of wines online.
Visit Healthgrades for information on Dr. Howard Rosenthal, DDS Find Phone & Address information, medical practice history, affiliated hospitals and more.
Visit Healthgrades for information on Dr. Robert Rosenthal, MD Find Phone & Address information, medical practice history, affiliated hospitals and more.
Listen free to Tom Rosenthal - The Pleasant Trees (Its OK, Going To be Wonderful and more). 6 tracks (16:49). Discover more music, concerts, videos, and pictures with the largest catalogue online at Last.fm.
Nikolai Rosenthal is the author of this article in the Journal of Visualized Experiments: תכנון ויישום מערכת עצבים בסימולציות לגו רובוטים
A young Southern woman of modest means suddenly finds herself thrust into New Yorks high society when she discovers that she is the illegitimate daughter of...
Purpose: : In our previous studies, we have demonstrated that alpha-crystallins can negatively regulate stress-induced apoptosis through suppression of the ERK-mediated pathway and activation of the AKT signaling pathway. In the present study, we present evidence to show that alpha-crystallins can regulate the ATR-p53 pathway to prevent UVA-induced apoptosis. Methods: : UVA was used to irradiate human lens epithelial cells stably expressing vector, alphaA, and alphaB. Western blot analysis was used for detection of ATR, CHK1/2 and p53 activation. Reporter gene activity assay was used to explore the transactivity of p53. Hoechst staining was used for apoptosis assay. Results: : Human lens epithelial cells expressing either alphaA- or alphaB-crystallin are substantially resistant to UVA-induced apoptosis. UVA-induces activation of ATR and CHK1/2 kinases to activate p53 in vector-transfected cells. However, in alphaA- or alphaB-crystallin-transfected cells, activation of ATR, CHK1/2 kinases and p53 ...
Alexander disease, also known as fibrinoid leukodystrophy, is a progressive and fatal neurodegenerative disease. It is a rare genetic disorder and mostly affects infants and children, causing developmental delay and changes in physical characteristics. Delays in development of some physical, psychological and behavioral skills; progressive enlargement of the head (macrocephaly), seizures, spasticity, and in some cases also hydrocephalus, idiopathic intracranial hypertension, and dementia. Alexander disease is a genetic disorder affecting the midbrain and cerebellum of the central nervous system. It is caused by mutations in the gene for glial fibrillary acidic protein (GFAP) that maps to chromosome 17q21. It is inherited in an autosomal dominant manner, such that the child of a parent with the disease has a 50% chance of inheriting the condition, if the parent is heterozygotic. However, most cases arise de novo as the result of sporadic mutations. Alexander disease belongs to leukodystrophies, a ...
Mycobacterium tuberculosis (Mtb) forms biofilms harbouring antibiotic-tolerant bacilli in vitro, but the factors that induce biofilm formation and the nature of the extracellular material that holds the cells together are poorly understood. Here we show that intracellular thiol reductive stress (TRS) induces formation of Mtb biofilms in vitro, which harbour drug-tolerant but metabolically active bacteria with unchanged levels of ATP/ADP, NAD(+)/NADH and NADP(+)/NADPH. The development of these biofilms requires DNA, RNA and protein synthesis. Transcriptional analysis suggests that Mtb modulates only ∼7% of its genes for survival in biofilms. In addition to proteins, lipids and DNA, the extracellular material in these biofilms is primarily composed of polysaccharides, with cellulose being a key component. Our results contribute to a better understanding of the mechanisms underlying Mtb biofilm formation, although the clinical relevance of Mtb biofilms in human tuberculosis remains ...
... , Authors: Dessen P. Published in: Atlas Genet Cytogenet Oncol Haematol.
... , Authors: Dessen P. Published in: Atlas Genet Cytogenet Oncol Haematol.
Health,...SALT LAKE CITY -- Antioxidants are widely considered an important defe...The findings published in the Aug. 10 issue of Cell indicate a new c...The protein alpha B-Crystallin termed a molecular chaperone normally...In a study of laboratory mice with failing hearts caused by mutant alp...,Reductive,stress,linked,to,heart,disease,medicine,medical news today,latest medical news,medical newsletters,current medical news,latest medicine news
The eleven students involved learned basic experimental design (with positive and negative controls), troubleshooting, a wide variety of laboratory techniques, and data collection, analysis and presentations skills. In addition, students learned to read and analyze scientific work from other labs since they are given scientific articles to read beginning on their first day in the lab. This project is in collaboration with Ivor Benjamin M.D., Ph.D. at the University of Utah, which allowed these students the unique opportunity of discussing their research with a larger audience once a month. In addition to intellectual enrichment, students learned to function as a team, with those more experienced (graduate students Kelsey Langston and Whitney Hayes) mentoring those who are new in the lab. As students progressed in their understanding of the project and mastery of basic laboratory skills, they become involved in planning our weekly group meeting, preparing figures for presentations/publications, ...
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View mouse Hspb11 Chr4:107253593-107279938 with: phenotypes, sequences, polymorphisms, proteins, references, function, expression
Singh BN, Rao KS, Rao ChM (2010) Ubiquitin-proteasome-mediated degradation and synthesis of MyoD is modulated by alphaB-crystallin, a small heat shock protein, during muscle differentiation. Biochim Biophys Acta 1803, 288-99 20005263 ...
Emed, A.; Rosenthal, Móricz.; Grünfeld, József.; Spitzer, Sándor., 2003: Hungarian physicians in Vienna: Móric Rosenthal, József Grünfeld, Sándor Spitzer
Dr. Norman Rosenthal, MD is a psychiatry specialist in Rockville, MD. Dr. Rosenthal completed a residency at Ny State Psychology Institute. He currently practices at Capital Clinical Research Assocs.
Helianthus annuus hsp17.6 G1 protein: a small heat-shock protein from sunflower; amino acid sequence in first source; GenBank Z95153
https://twitter.com/#!/CCSVI_Society Dr. Alexander (endothelial biologist) now presenting MS and cerebral endothelial dysfunctionDr. Alexander: endothelium becomes sticky with shear: activates leukocytes into brain parenchyma Dr. Alexander: endothelial cells very sensitive to glycemic (glucose) and oxidative stressDr. Alexander: Interferon beta may have ...
Mikecz, K., Glant, T. T., Markovics, A., Rosenthal, K. S., Kurko, J., Carambula, R. E., Cress, S., Steiner, H. L. & Zimmerman, D. H., Jul 13 2017, In : Vaccine. 35, 32, p. 4048-4056 9 p.. Research output: Contribution to journal › Article ...
Rosenthal, A S., "Determinant selection and macrophage function in genetic control of the immune response." (1978). Subject Strain Bibliography 1978. 3821 ...
Read ratings and reviews for Dr. Randall Rosenthal who has 28 years of experience as a Obstetrician & Gynecologist in Newport, RI.
Heat-stress induced alterations in localization of small heat shock proteins in mouse myoblasts: intranuclear lamin A/C speckles as target for ?B-crystallin and hsp ...
Complete information for HSPA2 gene (Protein Coding), Heat Shock Protein Family A (Hsp70) Member 2, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
WHAT fellow art thou, who darest thus to lie at thy ease in our presence, when all others, as thou seest, rise to do us homage? dost thou not know us?. Diog. I cannot say I do: but by the number of thy attendants, by the splendour of thy habit; but, above all, by the vanity of thy appearance, and the arrogance of thy speech, I conceive thou mayst be Alexander the son of Philip.. Alex. And who can more justly challenge thy respect, than Alexander, at the head of that victorious army, who hath performed such wonderful exploits, [1] and, under his conduct, hath subdued the world?. Diog. Who? why the tailor who made me this old cloke.. Alex. Thou art an odd fellow, and I have a curiosity to know thy name.. Diog. I am not ashamed of it: I am called Diogenes: a name composed of as many and as well-sounding syllables as Alexander.. Alex. Diogenes, I rejoice at this encounter. I have heard of thy name, and been long desirous of seeing thee; in which wish, since fortune hath accidentally favoured me, I ...
Alexander disease results from gain of function mutations in the gene encoding glial fibrillary acidic protein (GFAP). At least eight GFAP isoforms have been described, however, the predominant alpha isoform accounts for approximately 90% of GFAP protein.