TY - JOUR. T1 - Induction of detoxifying enzymes by garlic organosulfur compounds through transcription factor Nrf2. T2 - Effect of chemical structure and stress signals. AU - Chen, Chi. AU - Pung, Daniel. AU - Leong, Vasco. AU - Hebbar, Vidya. AU - Shen, Guoxiang. AU - Nair, Sujit. AU - Li, Wenge. AU - Tony Kong, A. N.. PY - 2004/11/15. Y1 - 2004/11/15. N2 - Garlic organosulfur compounds (OSCs) are recognized as a group of potential chemopreventive compounds. It is known that garlic OSCs can modulate drug metabolism systems, especially various phase II detoxifying enzymes, though the mechanism underlying their inductive effect on these enzymes remains largely unknown. In the present study, we investigated the transcriptional levels of NAD(P)H:quinone oxidoreductase 1 (NQO1) and heme oxygenase 1 (HO1) genes, the reporter activity mediated by antioxidant response element (ARE), and the protein level of transcription factor nuclear factor E2-related factor 2 (Nrf2), after administration of three ...

Diallyl trisulfide (DATS), also known as Allitridin, is an organosulfur compound with the formula S(SCH2CH=CH2)2. It is one of several produced by the hydrolysis of allicin, including diallyl disulfide and diallyl tetrasulfide, DATS is one of the most potent. Many health benefits of garlic are attributed in part to DATS. These benefits include anti-cancer effects, platelet aggregation, blood pressure reduction, decreases in cholesterol levels, and increases in levels of reactive oxygen species. DATS has been shown to selectively kill cancerous cells in the prostate and breast, leaving healthy cells unharmed. This effect is attributed to increased reactive oxygen species (ROS) within cancer cells, increased the number of cells that arrest in the G2 phase of mitosis, and promote an increase in caspase-3 activity. These effects appear to contribute to the apoptosis of cancer cells and a decrease in cancer cell proliferation. DATS can be metabolized by glutathione in red blood cells to form hydrogen ...

There are comments on PubPeer for publication: Diallyl trisulfide (DATS) abrogates arsenic induced testicular oxidative stress in rats (2014)

Epigenetic upregulation of metallothionein 2A by diallyl trisulfide enhances chemosensitivity of human gastric cancer cells to docetaxel.

diallyl disulfide 2179-57-9 Precursor and Downstream products, diallyl disulfide Precursor products, diallyl disulfide Downstream products ect.

Diallyl sulfide (DAS), diallyl disulfide (DADS) and diallyl trisulfide (DATS) are major oil-soluble organosulfur compounds of garlic responsible for most of its pharmacological effects. The present study investigated the influence of repeated intraperitoneally (ip) administration of DAS, DADS and DATS on the total level of sulfane sulfur, bound sulfur (S-sulfhydration) and hydrogen sulfide (H2S) and on the activity of enzymes, which catalyze sulfane sulfur formation and transfer from a donor to an acceptor in the normal mouse kidney, i.e., γ-cystathionase (CSE) and rhodanese (TST). The activity of aldehyde dehydrogenase (ALDH), which is a redox-sensitive protein, containing an -SH group in its catalytic center, was also determined. The obtained results indicated that all tested compounds significantly increased the activity of TST. Moreover, DADS and DATS increased the total sulfane sulfur level and CSE activity in the normal mouse kidney. ALDH activity was inhibited in the kidney after DATS

1574 Epidemiological data continues to support the notion that increased consumption of Allium vegetables may reduce the risk for different types of malignancies including cancer of the prostate. Moreover, allium vegetable derived organosulfur compounds, such as diallyl trisulfide (DATS; CH2=CH-CH2-(S)3-CH2-CH=CH2), are highly effective in affording protection against cancer development in animal models. Evidence is mounting to indicate that garlic-derived organosulfur compounds can suppress proliferation of cultured cancer cells by inhibiting cell cycle progression and causing apoptosis induction. Previous studies including those from our laboratory have offered novel insights into the mechanism of apoptosis induction by DATS. For instance we showed previously that DATS-induced apoptosis in PC-3 and DU145 human prostate cancer cells was associated with c-jun N-terminal kinase mediated phosphorylation of Bcl-2, which reduced Bax-Bcl-2 interaction to trigger activation of caspase-9/3. In the ...

US EPA PC Code ); 006901 (US EPA PC Code Text ); 12044-79-0 (CAS number); 12044790; 12044790 (CAS number without hyphens); 12344682; 12612214; 1303-33-9 (CAS number); 1303-34-0 (CAS number); 1303339; 1303339 (CAS number without hyphens); 1303340; 1303340 (CAS number without hyphens); 56320220; Arsenic disulfide (CAS 56320-22-0); Arsenic sesquisulfide; Arsenic sesquisulfide (CAS 1303-33-9); Arsenic sulphide; Arsenic trisulfide; Arsenic trisulfide (As2S3); Arsenic trisulfide (CAS 1303-33-9); Arsenic trisulphide; Arsenic yellow; Arsenic yellow (CAS 1303-33-9); Arsenictrisulfide; Arsenone S; Arsenone S (CAS 12344-68-2); Diarsenic pentasulfide; Diarsenic pentasulfide (CAS 1303-34-0); Diarsenic tetrasulfide; Diarsenic tetrasulfide (CAS 12344-68-2); Diarsenic trisulfide; Diarsenic trisulfide (CAS 1303-33-9); Thioxoarsino; Thioxoarsino (CAS 12044-79-0 ...

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Allylstannanes are relatively stable reagents in the allylmetal family, and have been employed in a variety of complex organic syntheses. In fact, allylstannane addition is one of the most common methods for producing polypropionates, polyacetates, and other oxygenated molecules with a contiguous arrays of stereocenters.[10] Ley and coworkers[11] used an allylstannane to allylate a threose-derived aldehyde (see figure) en route to the macrolide antascomicin B, which structurally resembles FK506 and rapamycin, and is a potent binder of FKBP12. Allylboration is also often used to add allyl groups in a 1,2 fashion to aldehydes and ketones. Thanks to decades of research, there is now a wide variety of organoboron reagents available to the synthetic chemist, including organoboranes that predictably yield products in high diastereo- and enantioselectivity.[12] If a one-pot metal insertion and allylation procedure is required, indium- mediated allylation is an attractive option for generating ...

A number of studies on garlic have appeared dealing with diallyl sulfide and cancer. One from the Republic of Korea cites diallyl disulfide (DADS) as the most prevalent oil-soluble sulfur compound in garlic, inhibiting cell proliferation in many cell lines. Scientists there examined DADS ability to kill cells in a process involving free radical production. They found that the famous tumor suppressor gene, p53, arrested the cell cycle when DADS treatment was present. Cancer cells died following 24 hour DADS treatment that activated the p53 gene. They also found that DADS induced cell death was prevented by treatment with a compound known to prevent p53 dependent cell death by reducing free radical levels in the mitochrondria, the cellular furnaces. Their results showed that mitochrondrial free radicals may serve as second messengers in DADS-induced cell death, which requires activation of p53. That study was found in the Journal of Biochemical and Molecular Toxicology ...

A number of studies on garlic have appeared dealing with diallyl sulfide and cancer. One from the Republic of Korea cites diallyl disulfide (DADS) as the most prevalent oil-soluble sulfur compound in garlic, inhibiting cell proliferation in many cell lines. Scientists there examined DADS ability to kill cells in a process involving free radical production. They found that the famous tumor suppressor gene, p53, arrested the cell cycle when DADS treatment was present. Cancer cells died following 24 hour DADS treatment that activated the p53 gene. They also found that DADS induced cell death was prevented by treatment with a compound known to prevent p53 dependent cell death by reducing free radical levels in the mitochrondria, the cellular furnaces. Their results showed that mitochrondrial free radicals may serve as second messengers in DADS-induced cell death, which requires activation of p53. That study was found in the Journal of Biochemical and Molecular Toxicology ...

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Allyl chloride definition, a colorless, volatile, flammable liquid, C 3 H 5 Cl, having a pungent odor, derived from propylene by chlorination: used chiefly in the synthesis of allyl alcohol, resins, and pharmaceuticals. See more.

This topic has 2 study abstracts on Diallyl sulfide indicating that it may have therapeutic value in the treatment of Androgen Deficiency, Cadmium Poisoning, and Testicular Diseases

Thejass, P.; Kuttan, G., 2007: Inhibition of angiogenic differentiation of human umbilical vein endothelial cells by diallyl disulfide (DADS)

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AIM: To investigate the mechanism of allitridi-induced apoptosis in human gastric cancer cell line BGC823. METHODS: Growth inhibition by allitridi was analyzed using cell growth curve and MTT assay. Apoptotic cells were detected using staining with Hoechst 33342, and confirmed by flow cytometric analysis and DNA fragmentation analysis. The protein expression affected by allitridi was determined using Western blot. The activity of caspase-3 was measured using a fluorescence assay. RESULTS: Allitridi induced apoptosis, and then inhibited cells proliferation in human gastric cancer cell line BGC823. The protein level of Bcl-2 was decreased dramatically, while Bax and p53 were not significantly affected by allitridi. The expression and activity of caspase-3 started to increase after allitridi treatment for 72 h. CONCLUSION: Allitridi induced apoptosis through down-regulation of Bcl-2, and increased caspase-3 expression and its activity. ...

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Arsenic trisulfide definition, a yellow or red crystalline substance, As 2 S 3 , occurring in nature as the mineral orpiment, and used as a pigment (kings yellow) and in pyrotechnics. See more.

Sulfur represents approximately 1/4% of our total body weight and occurs principally in the body as a constituent of the cysteine and methionine. It plays an important role in protein synthesis and enzyme reaction functions and is found abundantly in broccoli, cauliflower, cabbage, kale, kohlrabi, etc. Organosulfides Organosulfur compounds presented in natural food are generally …. ...

Diallyl sulfide (DAS) and diallyl disulfide (DADS) are natural components that could account for the anticarcinogenic properties of garlic, at least in part, through the activation of xenobiotic detoxifying metabolism. The aim of this work was to describe the effect of DAS and DADS on xenobiotic-related gene expressions and to study molecular mechanisms relaying DAS effect. We describe the different effects of DAS and DADS on hepatic CYP2B1/2, CYP3A and epoxide hydrolase (EpH) mRNAs in rats, in terms of activation profile, doses and kinetics. The activation profile varied with the mode of chemical administration, i.e. gastric infusion or intraperitoneal (i.p.) injection. Using gastric infusion, DAS and DADS proved different efficiencies at enhancing the mRNA level of the three drug-metabolizing enzymes. After an i.p. administration, we observed a specific activation of CYP2B1/2 gene by DAS. The DAS-mediated CYP2B1/2 activation occurred at transcriptional level and through an okadaic ...

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AR plays an important role in the development of prostate cancer as well as in the transition to castration-resistant state, which is highly aggressive and resistant to chemotherapy (4, 38). Thus, the preclinical/clinical development of novel agents that are safe but can suppress AR signaling is highly desirable. The present study shows that DATS treatment suppresses protein level of AR in both LNCaP cells and their androgen-independent variant. The DATS-mediated AR protein down-regulation is maintained for at least up to 24 hours even after removal of the drug. In addition, DATS treatment exhibits significant antiproliferative effect against androgen-stimulated growth of LNCaP cells.. We also conclude that the DATS-mediated suppression of AR protein level leads to inhibition of transcriptional activity of AR as evidenced by a significant decrease in secreted as well as intracellular levels of PSA in both LNCaP and C4-2 cells. Structure-activity analysis reveals that even a subtle change in the ...

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Butyl methyl trisulfide | C5H12S3 | CID 189722 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.

Sigma-Aldrich offers abstracts and full-text articles by [Fenja Klevenhusena, Stephane Duval, Johanna O Zeitz, Michael Kreuzer, Carla R Soliva].

Abstract: The Asia Pacific trans-1,3-dichloropropene market size is $XX million USD in 2018 with XX CAGR from 2015 to 2018, and it is expected to reach $XX million USD by the end of 2025 with a CAGR of XX% from 2020 to 2025. This report is an essen...

The report generally describes allyl acetate, examines its uses, production methods, patents. Allyl acetate market situation is overviewed; allyl acetate

6,8-diallyl 5,7-dihydroxy 2-(2-allyl 3-hydroxy 4-methoxyphenyl)1-H benzo(b)pyran-4-one: inhibitor of cell adhesion and atherosclerosis that targets nadph oxidase

178366-78-4 - 6,8-Diallyl 5,7-dihydroxy 2-(2-allyl 3-hydroxy 4-methoxyphenyl)1-H benzo(b)pyran-4-one - Searchable synonyms, formulas, resource links, and other chemical information.

Facile formation of allylzinc species from allylboronate and zinc amide was discovered. The boron-to-zinc exchange process occurred smoothly to afford the corresponding allylzinc amides, which were successfully employed in catalytic allylation reactions with electrophiles. Asymmetric catalysis using a chiral

A topical formulation includes a water-soluble ingredient and an oil-soluble ingredient and includes a combination of water, a rheology modifier, and a water miscible organic solvent to stabilize the composition.

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J Am Acad Dermatol. 1990 Feb;22(2 Pt 1):231-8. Review.. Inhibition of benzoyl peroxide-mediated tumor promotion in 7,12-dimethylbenz(a)anthracene-initiated skin of Sencar mice by antioxidants nordihydroguaiaretic acid and diallyl sulfide ...

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Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice ...

A crosslinking agent containing a polyallyl ether compound having at least one hydroxyl group derived from a glycidyl group and at least two allyl groups can be used for the production of a highly water-absorbing polymer comprising a polymerizable compound having a carbon-carbon double bond or a salt thereof, has a high solubility in aqueous solution of the monomer and gives a highly water-absorbing polymer having water absorptivity required at practical levels.

Looking for Disulphide? Find out information about Disulphide. A compound that has two sulfur atoms bonded to a radical or element. One of a group of organosulfur compounds RSSR′ that may be symmetrical or unsymmetrical Explanation of Disulphide

The 68845NV basic set includes 12 carbons, 18 hydrogens & 1 2 hole sulfur atom sufficient to build at least one basic organosulfur compound.

Im Greg, an autistic dad self-diagnosed at age 31. I have twin three year olds, one of whom is autistic. Im new to the autism community only in the sense that my son introduced my partner Meg and I…

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It is a bright and sunny morning here in San Sebastian, Spain. Josh just returned from a run across the Puente Maria Christina and I just received our first email from Rotunda since the embryos were transferred two weeks ago. It appears that the HCG level of our surrogate is a 4.05, which means that…

Rob Van Driel is the Daddy on a mission after the early arrival of his daughter, Charlie, at 31 weeks gestation in June last year. Charlie was six weeks old