EWGs Tap Water Database Perfluorooctane sulfonate (PFOS) results for North Las Vegas Utilities | Perfluorooctane sulfonate (PFOS). Find out what is in your tap water
EWGs Tap Water Database Perfluorooctane sulfonate (PFOS) results for Belton | Perfluorooctane sulfonate (PFOS). Find out what is in your tap water
Having found previously that high-dose, short-term dietary exposure of mice to perfluorooctanesulfonate (PFOS) or perfluorooctanoate (PFOA) suppresses adaptive immunity, in the present study we characterize the effects of these fluorochemicals on the innate immune system. Male C57BL/6 mice receiving 0.02% (w/w) PFOS or PFOA in their diet for 10 days exhibited a significant reduction in the numbers of total white blood cells (WBC), involving lymphopenia in both cases, but neutropenia only in response to treatment with PFOA. Moreover, both compounds also markedly reduced the number of macrophages (CD11b(+) cells) in the bone marrow, but not in the spleen or peritoneal cavity. The ex vivo production of tumor necrosis factor-alpha (TNF-alpha) and interleukin 6 (IL-6) by peritoneal macrophages isolated from animals treated with PFOA or PFOS was increased modestly. Moreover, both fluorochemicals markedly enhanced the ex vivo production of these same cytokines by peritoneal and bone marrow macrophages ...
TY - JOUR. T1 - Novel non-targeted analysis of perfluorinated compounds using fluorine-specific detection regardless of their ionisability (HPLC-ICPMS/MS-ESI-MS). AU - Azua Jamari, Nor Laili. AU - Dohmann, Jan Frederik. AU - Raab, Andrea. AU - Krupp, Eva M.. AU - Feldmann, Joerg. N1 - NLAJ thanks the Malaysian Government (Grant number: RG12824-10) and the National Defence University of Malaysia for financial support throughout the study period, while JFD thanks the Erasmus program of the EU. Special thanks to the Swedish Research Council (Grant number: FORMAS 1397306) for additional financial support in this project.. PY - 2019/4/11. Y1 - 2019/4/11. N2 - Although perfluorooctanesulfonic acid (PFOS) and perfluorooctanoic acid (PFOA) have been phased out, there is a plethora of per- or polyfluoroalkyl substances (PFAS) generated and only a small number of these compounds are currently being monitored in environmental and biological sample using molecular mass spectrometry (MS). Total fluorine ...
Concentrations of perfluorinated chemicals (PFCs) were measured in surface waters and sediments from the Coosa River watershed in northwest Georgia, USA, to examine their distribution downstream of a suspected source. Samples from eight sites were analyzed using liquid chromatography‐tandem mass spectrometry. Sediments were also used in 28‐d exposures with the aquatic oligochaete, Lumbriculus variegatus, to assess PFC bioaccumulation. Concentrations of PFCs in surface waters and sediments increased significantly below a land‐application site (LAS) of municipal/industrial wastewater and were further elevated by unknown sources downstream. Perfluorinated carboxylic acids (PFCAs) with eight or fewer carbons were the most prominent in surface waters. Those with 10 or more carbons predominated sediment and tissue samples. Perfluorooctane sulfonate (PFOS) was the major homolog in contaminated sediments and tissues. This pattern among sediment PFC concentrations was consistent among sites and reflected
TY - JOUR. T1 - Perfluorooctane sulfonate-induced hepatic steatosis in male sprague dawley rats is not attenuated by dietary choline supplementation. AU - Bagley, Bradford D.. AU - Chang, Shu Ching. AU - Ehresman, David J.. AU - Eveland, Alan. AU - Zitzow, Jeremiah D.. AU - Parker, George A.. AU - Peters, Jeffrey M.. AU - Wallace, Kendall B.. AU - Butenhoff, John L.. N1 - Publisher Copyright: © The Author 2017. Published by Oxford University Press on behalf of the Society of Toxicology. All rights reserved.. PY - 2017/12/1. Y1 - 2017/12/1. N2 - Perfluorooctane sulfonate (PFOS) is an environmentally persistent chemical. Dietary 100ppm PFOS fed to male mice and rats for 4 weeks caused hepatic steatosis through an unknown mechanism. Choline deficient diets can cause hepatic steatosis. A hepatic choline:PFOS ion complex was hypothesized to cause this effect in mice. This study tested whether dietary choline supplementation attenuates PFOS-induced hepatic steatosis in rats. Sprague Dawley rats ...
Article Perfluorinated chemicals (PFCs) in water purification plants (WPPs) with advanced treatment processes. A series of perfluorinated chemicals (PFCs) surveys were conducted in two water purification plants (WPPs) having ozonation and granular ac...
The European Commission this year will consider a proposal to restrict the manufacture or sale of perfluorohexane sulfonic acid (PFHxS), its salts, or substances that degrade into PFHxS. These chemicals are used as water and stain repellents in textile treatment, according to the European Chemicals Agency (ECHA). They are part of a group known as per- and polyfluoroalkyl substances (PFAS) that are highly persistent in the environment. PFHxS is highly bioaccumulative and has been detected in human blood and in wildlife in the Arctic and other remote places. Use of PFHxS and its related compounds has declined in recent years, ECHA says, adding that current annual emissions of these substances in the EU are estimated at about 0.42 metric tons. Norway initiated the proposal to restrict PFHxS and its related compounds, with the goal to prevent their use in place of perfluorooctanesulfonic acid, which is already banned in the European Union, or perfluorooctanoic acid, which will be prohibited there as ...
Perfluoroalkyl acids (PFAAs) are man-made chemicals. Their unique properties make them beneficial for a wide range of industrial and consumer applications, such as constituents in fire fighting foams, hydraulic oils and food packaging materials.PFAAs have shown to be highly persistent in the environment, and the toxicological potential of long chain PFAA homologues is of a concern. International regulation and voluntary actions by the industry have been implemented and led to reduced primary emissions of PFAAs to the environment. However, the concentrations of some PFAAs in e.g. birds from the Baltic Sea are still very high and of ecotoxicological concern. Measures to reduce the PFAA contamination require an understanding of the sources and how the PFAAs are being transported in the environment.In this licentiate thesis a mass balance was assembled for perfluorohexanoic acid (PFHxA), perfluorooctanoic acid (PFOA), perfluorodecanoic acid (PFDA) and perfluorooctane sulfonic acid (PFOS) in the ...
Little is known about factors influencing infant perfluorinated alkyl acid (PFAA) concentrations. Associations between serum PFAA concentrations in 2-4-month-old infants (n = 101) and determinants were investigated by multiple linear regression and general linear model analysis. In exclusively breastfed infants, maternal serum PFAA concentrations 3 weeks after delivery explained 13% (perfluoroundecanoic acid, PFUnDA) to 73% (perfluorohexanesulfonate, PFHxS) of infant PFAA concentration variation. Median infant/maternal ratios decreased with increasing PFAA carbon chain length from 2.8 for perfluoroheptanoic acid and perfluorooctanoic acid (PFOA) to 0.53 for PFUnDA and from 1.2 to 0.69 for PFHxS and perfluorooctanesulfonate (PFOS). Infant PFOA, perfluorononanoic acid (PFNA), and PFOS levels increased 0.7-1.2% per day of gestational age. Bottle-fed infants had mean concentrations of PFAAs 2 times lower than and a mean percentage of branched (%br) PFOS isomers 1.3 times higher than those of ...
Market Research Reports Search Engine (MRRSE) has been serving as an active source to cater intelligent research report to enlighten both readers and investors. This research study titled Sodium Lauryl Sulfate Market. Request a Free Sample Report @ https://www.mrrse.com/sample/984. Increasing demand for sodium lauryl sulfate (SLS), sodium laureth ether sulfate (SLES) and linear alkylbenzene sulfonate (LAS) from detergents & cleaners and personal care industries is expected to drive the global SLS, SLES & LAS market in the next five years. However, the adverse effect of SLS and SLES on human skin coupled with fluctuation in prices of linear alkylbenzene sulfonate is anticipated to hamper market growth. Emerging applications such as paints & coatings and oilfield chemicals are estimated to offer immense opportunities for players in the market. SLS, SLES and LAS are the major forms of anionic surfactants. However, LAS accounts for nearly 40% of the global anionic surfactants market.. The report ...
http://www.ntn.org.au/featured/firefighters-community-and-environment-at-risk-from-perfluorinated-chemcialsFirefighters, community and environment at risk from perfluorinated chemcialsNTN has released its new report on the Persistence and Toxicity of Perfluorinated Compounds in Australia.
ASTM-D1768 Standard Test Method for Sodium Alkylbenzene Sulfonate in Synthetic Detergents by Ultraviolet Absorption - sodium alkylbenzene sulfonate; synthetic detergents; ultraviolet absorption ;; ICS Number Code 71.100.40 (Surface active agents)
Get Information of Alkylbenzene Sulfonate Manufacturers, Suppliers, Dealers, Exporters, Traders, Producers, Wholesalers, Alkylbenzene Sulfonate Companies in Aurangabad, India
We utilized milk samples obtained from a survey of 219 primiparous mothers in 2009 to test for the presence of new persistent organic pollutants: hexachlorocyclohexane (HCH), pentachlorobenzene (PeCB), chlordecone, polybrominated biphenyls (PBBs), polybrominated diphenyl ethers (PBDEs), and perfluorinated compounds (PFCs), including perfluorooctane sulfonic acid (PFOS), perfluorooctane sulfonyl fluoride (PFOS-F), and perflurooctanoic acid (PFOA). 158 samples were pooled according to the mothers age, length of stay in Hong Kong, and their dietary habits (frequencies of intake of fish and other seafood, and milk and dairy products) and tested for chlordecone, PBDEs, PBBs and PFCs. All were present in our samples. Their mean and median concentrations are very high compared to findings in other countries. HCH and PeCB were tested in 73 individual samples and their mean levels were of the same order of magnitude as those reported in our previous study. The levels of PBDEs were positively associated ...
Paola Irato, Sara Trabucco and Laura Tallandini-Emerging Contaminants Such as Perfluorinated Compounds: Toxicity andOxidative Stress
There is increasing global concern regarding the health impacts of perfluoroalkyl and polyfluoroalkyl substances (PFAS), which are emerging environmental endocrine disruptors. Results from previous epidemiological studies on the associations between PFAS exposure and sex hormone levels are inconsistent. We examined the associations between serum PFAS compounds (PFDeA, PFHxS, PFNA, PFOA, PFOS) and sex hormones, including total testosterone (TT), free testosterone (FT), estradiol (E), and serum hormone binding globulin (SHBG). After adjusting for potential confounders, PFDeA, PFOS, and PFHxS exposures were significantly associated with increased serum testosterone concentrations in males. PFDeA, PFOA, and PFOS exposures were positively correlated with FT levels in 20-49-year-old women, while PFOS exposure was negatively associated with TT levels in 12-19-year-old girls. PFAS exposure was negatively associated with estradiol levels including: PFDeA in all females, PFHxS, PFNA, PFOS, and PFOA in 12-19-year
A survey on seasonal concentration changes of perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) was performed for surface water in Lake Biwa (14 sites) from February to November in 20
Per- and polyfluoroalkyl substances (PFAS) are environmental chemicals linked to weight gain and type 2 diabetes.We examined the extent to which PFAS plasma concentrations during pregnancy were associated with postpartum anthropometry and biomarkers.We studied women recruited between 1999-2002 in the Project Viva prospective cohort with pregnancy plasma concentrations of PFAS, including perfluorooctanesulfonic acid (PFOS), perfluorooctanoic acid (PFOA), and 2-(N-ethyl-perfluorooctane sulfonamide) acetic acid (EtFOSAA). Three-year postpartum anthropometry measurements were available from 786-801 women, blood pressure from 761 women, and blood biomarkers from 450-454 women. We used multivariable regression to evaluate the association of log2-transformed PFAS with postpartum anthropometry, blood pressure, and blood biomarkers (leptin, adiponectin, sex hormone binding globulin [SHBG], hemoglobin A1c [HbA1c], interleukin-6 [IL-6], C-reactive protein [CRP]), adjusting for age, pre-pregnancy BMI, ...
Link: Shabalina Irina G, Kalinovich AV, Cannon B, Nedergaard J (2015) Event: MiP2015 The environmental pollutants perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) are degradation products of polyfluorinated surfactants and polymers that due to their unique surface-active properties, the stability of their C-F bonds and their thermal resistivity, are utilized in a wide variety of products, including fire-fighting foams, lubricants, paints, cosmetics and ski-wax. PFOS/PFOA cause a dramatic reduction in the size of the major adipose tissue depots when they are added to the food of mice. A large part of the effect of PFOA/PFOS on food intake was dependent on the presence of the uncoupling protein 1 (UCP1) in the brown adipose tissue [1]. We have examined here the possibility that PFOA/PFOS can directly (re)activate UCP1 in isolated mouse brown-fat mitochondria. In wildtype brown-fat mitochondria, PFOS and PFOA overcame GDP-inhibited thermogenesis, leading to increased oxygen ...
TY - JOUR. T1 - PFAS exposure and overweight/obesity among children in a nationally representative sample. AU - Geiger, Sarah Dee. AU - Yao, Ping. AU - Vaughn, Michael G.. AU - Qian, Zhengmin. N1 - Publisher Copyright: © 2020 Elsevier Ltd. PY - 2021/4. Y1 - 2021/4. N2 - Purpose: Perfluoroalkyl substances (PFASs) are a class of manmade chemicals commonly used in consumer product manufacturing. Perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) are two of the most highly studied PFASs. Both are present in the blood of the most Americans. PFASs are associated with intermediate cardiovascular disease (CVD) outcomes, but their relationship with obesity, a risk factor for intermediate and advanced CVD, remains largely unconfirmed. In this context, we aimed to explore the relationship between PFASs and both overweight/obesity and abdominal obesity among children. Methods: We examine associations between PFOA and PFOS levels, and Body Mass Index (BMI) and waist circumference (WC) in a ...
redOrbit Staff & Wire Reports - Your Universe Online. Researchers at NISTs Hollings Marine Laboratory (HML) and four partner organizations have measured for the first time concentrations of 13 perfluoroalkyl compounds (PFCs) in five endangered species of sea turtles. While PFC toxicology studies have not yet been conducted on turtles, the levels of the compounds seen in all five species approach the amounts known to cause unfavorable health effects in other animals.. PFCs are man-made compounds that have many uses including stain-resistant coatings, fire-fighting foams and emulsifiers in plastics manufacturing. They are detectable in human and wildlife samples worldwide, infiltrate food chains, and have been shown in laboratory animals - rats, mice and fish - to be toxic to the liver, the thyroid, neurobehavioral function and the immune system. The PFCs most frequently found in the environment are perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA).. Located in Charleston, S.C., ...
Per- and polyfluoroalkyl substances (PFAS) are a group of synthetic compounds found in a variety of household and industrial products. The two most studied compounds in this family, perfluorooctanoic acid (PFOA) and perfluorooctane sulfonic acid (PFOS), have been associated with a range of health concerns. The following webinar recording describes two pilot projects designed to measure human PFAS exposures undertaken by the Pennsylvania Department of Health and the New York State Department of Health. It focuses on the states use of the PFAS Exposure Assessment Technical Tools (PEATT)-a guidance document developed by CDC and the Agency for Toxic Substances and Disease Registry to measure human PFAS exposures through drinking water sources. Results from PEATT allow health officials to estimate levels of exposure for an entire affected community, not just those individuals tested. The PEATT also provides guidance on how to share results with affected communities.Read More ». ...
The IUPHAR/BPS Guide to Pharmacology. alkylbenzene sulfonate ligand page. Quantitative data and detailed annnotation of the targets of licensed and experimental drugs.
Article Adsorption of four perfluorinated acids on non ion exchange polymer sorbents. Perfluorinated compounds (PFCs) have attracted global concern due to their ubiquitous distribution and properties of persistence, bio accumulation and toxicity. The...
Several environmental contaminants, such as polychlorinated biphenyls, dioxins, bisphenol A and phthalates, have been linked to diabetes. We therefore investigated whether other kinds of contaminants, perfluoroalkyl substances (PFAS), also called perfluorinated compounds (PFCs), are also associated with diabetes. The Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study investigated 1,016 men and women aged 70 years. Seven PFAS were detected in almost all participant sera by ultra-high performance liquid chromatograph/tandem mass spectrometry. Diabetes was defined as use of hypoglycaemic agents or fasting glucose , 7.0 mmol/l. 114 people had diabetes. In the linear analysis, no significant relationships were seen between the seven PFAS and prevalent diabetes. However, inclusion of the quadratic terms of the PFAS revealed a significant non-linear relationship between perfluorononanoic acid (PFNA) and diabetes, even after adjusting for multiple confounders (OR 1.96, 95% CI ...
DOI: 10.1016/j.envpol.2020.115908. Perfluoroalkyl acids (PFAAs) are widely used in industrial production and daily life because of their unique physicochemical properties, such as their hydrophobicity, oleophobicity, surface activity, and thermal stability. Perfluorosulfonic acids (PFSAs) and perfluorocarboxylic acids (PFCAs) are the most studied PFAAs due to their global occurrence. PFAAs are environmentally persistent, toxic, and the long-chain homologs are also bioaccumulative. Exposure to PFAAs may arise directly from emission or indirectly via the environmental release and degradation of PFAA precursors. Precursors themselves or their conversion intermediates can present deleterious effects, including hepatotoxicity, reproductive toxicity, developmental toxicity, and genetic toxicity. Therefore, exposure to PFAA precursors constitutes a potential hazard for environmental contamination. In order to comprehensively evaluate the environmental fate and effects of PFAA precursors and their ...
MELVILLE, NY--(Marketwired - October 11, 2017) - Napoli Shkolnik PLLC has filed a class action lawsuit against five manufacturers of aqueous firefighting foams (AFFF) containing perfluorooctanesulfonic acid (PFOS) and perfluorooctanoic acid (PFOA) for the contamination of the groundwater relied upon by the residents of Yaphank, New York. The class action...
TY - JOUR. T1 - L-carnitine via PPARγ- and Sirt1-dependent mechanisms attenuates epithelial-mesenchymal transition and renal fibrosis caused by perfluorooctanesulfonate. AU - Chou, Hsiu Chu. AU - Wen, Li Li. AU - Chang, Chih Cheng. AU - Lin, Chien Yu. AU - Jin, Lu. AU - Juan, Shu Hui. PY - 2017/12/1. Y1 - 2017/12/1. N2 - We have previously reported that perfluorooctanesulfonate (PFOS) causes cell apoptosis in renal tubular epithelial cells (RTCs). Here, we extend our findings and provide evidence of epithelial-mesenchymal transition (EMT)-associated renal fibrosis caused by PFOS and the protection by L-carnitine. Our results demonstrate that PFOS increased the expression of EMT and renal injury biomarkers (eg, N-cadherin, vimentin, Snail, Kim1, and Lcn2). In addition, PFOS caused EMT induction through Sirt1-mediated PPARγ deacetylation and inactivation. L-carnitine reversed the EMT induction caused by PFOS and alleviated PFOS-mediated increases in cellmigration by reactivating PPARγ through ...
TY - JOUR. T1 - Molecular design of liquid crystalline poly(ester-amide)s with perfluoroalkyl spacers. AU - Teoh, May May. AU - Chung, Tai-Shung. AU - Cheng, Si Xue. AU - Lin, Ting Ting. AU - Pramoda, K. P.. PY - 2004/6/1. Y1 - 2004/6/1. N2 - We have introduced a series of perfluoroalkyl dicarboxylic acids with different lengths of fluorinated aliphatic segments into the 2,6-acetoxynaphthoic acid (ANA) and acetoxy acetanilide (AAA) systems; and their effects on the evolution of liquid crystal texture and liquid crystallinity have been investigated. The perfluoroalkyl dicarboxylic acids are tetrafluorosuccinic acid (TFSA, n = 2), hexafluoroglutaric acid (HFGA, n = 3), perfluorosuberic acid (PFSUA, n = 6) and perfluorosebacic acid (PFSEA, n = 8). Computational results based on the RIS Metropolis Monte Carlo method indicate that the ANA/AAA/perfluoroalkyl system may form thermotropic liquid crystalline polymers (LCPs) because the calculated persistence ratios are greater than 6.42. Computational ...
Chen, M-H, E-H Ha, T-W Wen, Y-N Su, G-W Lien, C-Y Chen, P-C Chen and W-S Hsieh. 2012. Perfluorinated compounds in umbilical cord blood and adverse birth outcomes.. Synopsis:. Babies exposed to higher levels of the chemical PFOS in the womb were born sooner and smaller than babies with lower exposures, suggests a new study of 429 babies from Taiwan. They also had smaller head circumferences.. PFOS levels in the babies umbilical cord blood were similar to those collected from U.S. and Canadian babies in 2004 - 2005. Birth outcomes were unaffected by the other studied chemicals - PFOA, PFNA and PFUA.. This is the first time that PFOS has been related to shorter pregnancies. Effects on birth weight and head circumference support the findings from previous studies.. The results are important because nearly everyone carries PFOS in their blood. Even subtle effects at an individual level can have important public health consequences at the population scale if everyone is exposed.. PFOS is a stain, ...
We reported the hepatic gene expression profiling in mice treated by perfluorooctanoate (PFOA) and high fat diet (HFD). Chronic HFD treatment was associated with gene expression changes in cholesterol biosynthetic process, lipid metabolic process, extracellular matrix, and inflammatory response pathways. Many chemokine related genes including Ccl2, Ccr2, Ccl3l3, Cx3cl1, Cx3cr1, Cxcl14, and toll-li...
PFCs are synthetic organic compounds, based on fluorine. Used in stain, heat and water-resistant products (eg Teflon). Toxic to lab animals. Bioaccumulative
Jusko T, Oktapodas M, Palkovi?ová Murinová ?, Babinska K, Babjakova J, Verner MA, DeWitt J, Thevenet-Morrison K, Conka K, Drobná B, Chovancova J, Thurston S, Lawrence BP, Dozier A, Jarvinen K, Patayova H, Trnovec T, Legler J, Hertz-Picciotto I, Lamoree MH. Demographic, Reproductive, and Dietary Determinants of Perfluorooctane Sulfonic (PFOS) and Perfluorooctanoic Acid (PFOA) Concentrations in Human Colostrum. Environmental science & technology.. 2016 Jul 5; 50(13):7152-62. Epub 2016 Jun 14. 5/ ...
Aceptado junio 2009. ABSTRACT. The aim of this study was to determine the effect of linear alkylbenzene sulfonate (LAS), anthracene and a LAS anthracene mixture on the growth of a microbial consortium isolated from polluted sediment. The microbial consortium was grown in a sterile glass bottle with mineral medium containing 1 g/L of glucose. Microbial growth inhibition produced by LAS, anthracene and combinations of LAS and anthracene was determined by viable count in nutritive agar; inhibitory concentration 50 (IC50) was calculated. The concentrations evaluated were 0.16, 0.8, 1.6, 16 and 160 mg/L of LAS or anthracene. The LAS anthracene mixtures were prepared by fixing either LAS or anthracene at 0.16 mg/L while increasing the other compound at the above concentrations. Microbial growth was sensitive to LAS at an IC50 of 8.22 and to anthracene at an IC50 of 5.2 mg/L. In the LAS anthracene combination, if LAS concentration was fixed and anthracene concentration varied, IC50 (5.92 mg/L) was ...
To determine whether exposure to per-and polyfluoroalkyl susbtances at an early developmental stage is associated with risk for autism spectrum disorders.
Alkanes C10-C13, chloro (short-chain chlorinated paraffins) (SCCPs): 10 000 mg/kg;. Aldrin: 5 000 mg/kg;. Chlordane: 5 000 mg/kg;. Chlordecone: 5 000 mg/kg;. DDT (1,1,1-trichloro-2,2-bis (4-chlorophenyl) ethane): 5 000 mg/kg;. Dieldrin: 5 000 mg/kg;. Endosulfan: 5 000 mg/kg;. Endrin: 5 000 mg/kg;. Heptachlor: 5 000 mg/kg;. Hexabromobiphenyl: 5 000 mg/kg;. Hexachlorobenzene: 5 000 mg/kg;. Hexachlorobutadiene: 1 000 mg/kg;. Hexachlorocyclohexanes, including lindane: 5 000 mg/kg;. Mirex: 5 000 mg/kg;. Pentachlorobenzene: 5 000 mg/kg;. Perfluorooctane sulfonic acid and its derivatives (PFOS). (C8F17SO2X). (X = OH, Metal salt (O-M+), halide, amide, and other derivatives including polymers): 50 mg/kg;. Polychlorinated Biphenyls (PCB) (3): 50 mg/kg;. Polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/PCDF) (4): 5 mg/kg;. Polychlorinated naphthalenes*: 1 000 mg/kg;. Sum of the concentrations of tetrabromodiphenyl ether C12H6Br4O), pentabromodiphenyl ether (C12H5Br5O), hexabromodiphenyl ether ...
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1. Shall not be manufactured, or placed on the market as substances on their own from 4 July 2020.. 2. Shall not, from 4 July 2020, be used in the production of, or placed on the market in: (a) another substance, as a constituent; (b) a mixture; (c) an article, in a concentration equal to or above 25 ppb of PFOA including its salts or 1 000 ppb of one or a combination of PFOA-related substances.. 3. Points 1 and 2 shall apply from:. (a) 4 July 2022 to: (i)equipment used to manufacture semi-conductors; (ii) latex printing inks. (b) 4 July 2023 to: (i) textiles for the protection of workers from risks to their health and safety; (ii) membranes intended for use in medical textiles, filtration in water treatment, production processes and effluent treatment; (iii) plasma nano-coatings. (c)4 July 2032 to medical devices other than implantable medical devices within the scope of Directive 93/42/EEC.. 4. Points 1 and 2 shall not apply to any of the following:. (a) perfluorooctane sulfonic acid and its ...
(2009) Benskin et al. Environmental Science and Technology. The exposure sources of perfluorooctane sulfonate (PFOS) in humans and wildlife are not well characterized. Human biomonitoring data show that PFOS profiles may consist of up to approximately 50% b...
Porous microspheres have fixed on the exterior surface thereof a coating of at least one of a perfluorinated oil, a fluorinated silicone oil or a silicone gum. The pores of the microspheres can be charged with a hydrophilic, lipophilic or perfluorinated phase. The microspheres are employed in cosmetic compositions.
Time to pregnancy for women with highest blood levels of two chemicals was 134% and 154% longer, vs. those with the lowest levels
Hepatotoxic perfluorinated chemicals Perfluorinated compounds are a group of manmade chemicals that were used for decades before their environmental significance was realised. Once they enter the environment they are incredibly stable and, along with several other groups of chemicals, have been labelled emerging contaminants. According to the US...
southern coastal Maine.. PFOS Concentrations in Osprey Eggs in Casco Bay [See graph]. • PCBs, PBDEs, PFCs and OCs were found in all of the osprey eggs sampled in 2007 and 2009.. • Deca-PBDE was detected in 10 of 12 osprey eggs collected in Casco Bay.. • PFOS in an egg from Flag Island were the highest ever seen in Maine wildlife, and among the highest ever observed in a bird egg.. • Fully 75 percent of osprey eggs had PFOS concentrations exceeding the threshold for negative health effects established for chickens (100 ng/g, wet weight).. • No spatial trend was detectable among the samples, suggesting that point sources, watershed characteristics and food web dynamics may all play a role in exposure to contaminants (Goodale 2010).. With support from CBEP and other partners, in 2007 BioDiversity Research Institute (BRI) began the first study to measure PBDEs, PFCs, PCBs, OCs and mercury in eggs from 23 species of birds in Maine from ocean, estuary, river, lake and terrestrial habitats. ...
Our study found that increased exposure to PFOA, PFOS, PFNA, and PFHxS was associated with higher odds of irregular and long menstrual cycle and lower risks of menorrhagia in women who plan to be pregnant. In contrast, women with higher levels of PFOA, PFNA, and PFHxS were more likely to have hypomenorrhea.. Two previous studies have evaluated the association between PFOA and PFOS and menstrual irregularity and length. Our results are consistent with those reported in a subset of 1,240 pregnant women randomly selected from the Danish National Birth Cohort (Fei et al. 2009). They found that the risk of irregular menstrual cycle was higher in women exposed to PFOA (15.0% in the upper three quartiles vs. 9.0% in the lowest quartile) and PFOS (14.2% in the upper three quartiles vs. 11.6% in the lowest quartile) (Fei et al. 2009). The INUENDO cohort enrolled 1,623 pregnant women in three countries (Greenland, Poland, and Ukraine) (Lyngsø et al. 2014) and found that PFOA exposure levels were ...
Perfluoroalkyl (PFAS) substances are widespread in the environment and in organisms. The fact that exposure to PFAS is associated with elevated cholesterol levels is a major concern for human health. Previous investigations, in which bovine serum albumin was frequently studied, indicate that PFOS, PFOA and PFNA bind to serum albumin. However, it is critical to know whether these and other PFAS have a preference for the protein or the lipid fraction in native human blood fractions. For this reason, blood samples from four young healthy volunteers (two women, two men, 23-31 years old) were used for protein size separation and fractionation by the Cohn method in combination with serial ultracentrifugation. The plasma fractions were analyzed for 11 PFAS using high-performance tandem mass spectrometry (HPLC-MS/MS). Although the data are based on a small sample, they clearly show that albumin is the most important carrier protein for PFOS, PFOA, PFHxS, PFNA and PFDA in native human plasma. These five ...
kinase 1/2 signaling in neurons and glial cells. Eur. J. Pharmacol. 674 (2-3), 104-111 Mahltig B, Cheval N, Astachov V, Malkoch M, Haase H, Fahmi A (2012) 2,5 Hydroxyl dendrimers as stabilizing agent for preparation of colloidal silver particles - a study in respect to antimicrobial properties and toxicity against human cells. Colloid Polym. Sci. 290:1413-1421 Haase H, Engelhardt G, Hebel S, Rink L (2011) Mercuric ions inhibit mitogen-activated protein kinase dephosphorylation by inducing reactive oxygen species. Toxicol. Appl. Pharmacol. 250(1), 78-86 Brieger A, Bienefeld N, Hasan R, Goerlich R, Haase H (2011) Impact of perfluorooctanesulfonate and perfluorooctanoic acid on human peripheral leukocytes. Toxicol. in Vitro. 25(4), 960-968 Mahltig B, Reibold M, Gutmann E, Textor T, Gutmann J, Haufe H, Haase H (2011) Preparation of Silver Nanoparticles Suitable for Textile Finishing Processes to Produce Textiles with Strong Antibacterial Properties against Different Bacteria Types. Z. Naturforsch. B ...
Perfluorooctanesulfonate (PFOS) was produced and used by various industries and in consumer products. Because of its persistence, it is ubiquitous in air, water, soil, wildlife, and humans. Although the adverse effects of PFOS on male fertility have been reported, the underlying mechanisms have not …
The widespread occurrence and environmental persistence of perfluorinated compounds (PFCs) received worldwide attention recently. Exhaustive analysis of all fluorinated compounds in an environmental sample can be daunting because of the constraints in the availability of analytical standards and extraction methods. Combustion ion chromatographic technique for trace fluorine analysis was used to assess the concentrations of known PFCs (e.g., PFOS, PFOA) and total fluorine (TF) in the blood of wild rats collected from Japan. The technique was further validated using tissues from PFOA-exposed rats. Six PFCs (PFOS, PFOSA, PFUnDA, PFDA, PFNA, and PFOA) were detected in all of the wild rat blood samples. Concentrations of extractable organic fluorine (EOF) in fraction 1 (Fr1; MTBE extraction) of wild rats ranged 60.9-134 ng F mL-1, while those in fraction 2 (Fr2; hexane) were below LOQ (32 ng F mL-1); TF concentrations in the blood of wild rats ranged from 59.9-192 ng F mL-1. The contribution of known ...
The project was initiated by the Danish Environmental Protection Agency, as a part of the Program for Cleaner Products, Area 1.7 Collection of knowledge and mapping of alternatives to problematic substances. The report contains the newest information about the properties, uses and occurrences of PFOS, PFOA and related polyfluorinated compounds. In addition, a search for and a preliminary assessment of possible alternatives to these types of chemicals were done. The report focuses mainly on the Danish situation but may also be a contribution to the PFOS/PFOA discussion at European level.. Today the largest use areas of PFOS-based compounds seem to be:. Cleaning agents for glass cleaning. Waxes and floor polishes. Photographic industry. Manufacturing of semiconductors. Metal surface treatment. PFOS and a range of related perfluorinated compounds are used in numerous industrial products and consumer products because of their special chemical properties, for instance the ability to repel both water ...