The first CIC to be studied was estradiol valerate/hydroxyprogesterone caproate (EV/OHPC) in 1963, and the second CIC to be studied was estradiol enantate/algestone acetophenide (E2-EN/DHPA) in 1964.[18][17] In 1967, E2-EN/DHPA was in the late stages of clinical development.[25][18] By 1969, the medication was available for medical use under the brand name Perlutal.[26] Within a few years, it was marketed under other brand names such as Topasel and Ova-Repos as well.[27][28][29][30] In addition, several other CICs had been introduced for medical use by 1972.[30] By 1976, two major CICs were in use: E2-EN/DHPA (brand names Perlutan, Topasel) in Spain and Latin America, and EV/OHPC (brand name Injectable No. 1) in China.[31] These CICs have been described as first-generation CICs.[31] Two second-generation CICs, estradiol cypionate/medroxyprogesterone acetate (EC/MPA; brand names Cyclofem and later Lunelle) and estradiol valerate/norethisterone enantate (EV/NETE; brand name Mesigyna), were ...
Perludil is an injectable contraceptive that is administered intramuscularly once a month. It consists of two main assets: a progestin (acetophenide algestone) and an estrogen (estradiol enanthate).. The main mode of action is in the contraceptive progestogen agent, which produces a anovulatory effect by inhibiting the secretion of pituitary gonadotropins. Estrogen ensures cyclic endometrial development and predictable bleeding patterns are generally similar to those that occur naturally in menstruation.. PRECAUTIONS: Before treatment and every year for this, it is recommended to perform the medical examination of the drug users, including complete gynecological Pap.. Smoking increases the risk of cardiovascular side effects. The total risk increases with patient age, especially after age 35. It is highly recommended that women who start a hormonal contraceptive therapy of any kind to refrain from smoking.. Perlutal ® has a transient inhibitory effect on ovulation, which does not lead to ...
Perludil is an injectable contraceptive that is administered intramuscularly once a month. It consists of two main assets: a progestin (acetophenide algestone) and an estrogen (estradiol enanthate).. The main mode of action is in the contraceptive progestogen agent, which produces a anovulatory effect by inhibiting the secretion of pituitary gonadotropins. Estrogen ensures cyclic endometrial development and predictable bleeding patterns are generally similar to those that occur naturally in menstruation.. PRECAUTIONS: Before treatment and every year for this, it is recommended to perform the medical examination of the drug users, including complete gynecological Pap.. Smoking increases the risk of cardiovascular side effects. The total risk increases with patient age, especially after age 35. It is highly recommended that women who start a hormonal contraceptive therapy of any kind to refrain from smoking.. Perlutal ® has a transient inhibitory effect on ovulation, which does not lead to ...
Perludil is an injectable contraceptive that is administered intramuscularly once a month. It consists of two main assets: a progestin (acetophenide algestone) and an estrogen (estradiol enanthate).. The main mode of action is in the contraceptive progestogen agent, which produces a anovulatory effect by inhibiting the secretion of pituitary gonadotropins. Estrogen ensures cyclic endometrial development and predictable bleeding patterns are generally similar to those that occur naturally in menstruation.. PRECAUTIONS: Before treatment and every year for this, it is recommended to perform the medical examination of the drug users, including complete gynecological Pap.. Smoking increases the risk of cardiovascular side effects. The total risk increases with patient age, especially after age 35. It is highly recommended that women who start a hormonal contraceptive therapy of any kind to refrain from smoking.. Perlutal ® has a transient inhibitory effect on ovulation, which does not lead to ...
Perludil is an injectable contraceptive that is administered intramuscularly once a month. It consists of two main assets: a progestin (acetophenide algestone) and an estrogen (estradiol enanthate).. The main mode of action is in the contraceptive progestogen agent, which produces a anovulatory effect by inhibiting the secretion of pituitary gonadotropins. Estrogen ensures cyclic endometrial development and predictable bleeding patterns are generally similar to those that occur naturally in menstruation.. PRECAUTIONS: Before treatment and every year for this, it is recommended to perform the medical examination of the drug users, including complete gynecological Pap.. Smoking increases the risk of cardiovascular side effects. The total risk increases with patient age, especially after age 35. It is highly recommended that women who start a hormonal contraceptive therapy of any kind to refrain from smoking.. Perlutal ® has a transient inhibitory effect on ovulation, which does not lead to ...
Perludil is an injectable contraceptive that is administered intramuscularly once a month. It consists of two main assets: a progestin (acetophenide algestone) and an estrogen (estradiol enanthate).. The main mode of action is in the contraceptive progestogen agent, which produces a anovulatory effect by inhibiting the secretion of pituitary gonadotropins. Estrogen ensures cyclic endometrial development and predictable bleeding patterns are generally similar to those that occur naturally in menstruation.. PRECAUTIONS: Before treatment and every year for this, it is recommended to perform the medical examination of the drug users, including complete gynecological Pap.. Smoking increases the risk of cardiovascular side effects. The total risk increases with patient age, especially after age 35. It is highly recommended that women who start a hormonal contraceptive therapy of any kind to refrain from smoking.. Perlutal ® has a transient inhibitory effect on ovulation, which does not lead to ...
Perludil is an injectable contraceptive that is administered intramuscularly once a month. It consists of two main assets: a progestin (acetophenide algestone) and an estrogen (estradiol enanthate).. The main mode of action is in the contraceptive progestogen agent, which produces a anovulatory effect by inhibiting the secretion of pituitary gonadotropins. Estrogen ensures cyclic endometrial development and predictable bleeding patterns are generally similar to those that occur naturally in menstruation.. PRECAUTIONS: Before treatment and every year for this, it is recommended to perform the medical examination of the drug users, including complete gynecological Pap.. Smoking increases the risk of cardiovascular side effects. The total risk increases with patient age, especially after age 35. It is highly recommended that women who start a hormonal contraceptive therapy of any kind to refrain from smoking.. Perlutal ® has a transient inhibitory effect on ovulation, which does not lead to ...
Perludil is an injectable contraceptive that is administered intramuscularly once a month. It consists of two main assets: a progestin (acetophenide algestone) and an estrogen (estradiol enanthate).. The main mode of action is in the contraceptive progestogen agent, which produces a anovulatory effect by inhibiting the secretion of pituitary gonadotropins. Estrogen ensures cyclic endometrial development and predictable bleeding patterns are generally similar to those that occur naturally in menstruation.. PRECAUTIONS: Before treatment and every year for this, it is recommended to perform the medical examination of the drug users, including complete gynecological Pap.. Smoking increases the risk of cardiovascular side effects. The total risk increases with patient age, especially after age 35. It is highly recommended that women who start a hormonal contraceptive therapy of any kind to refrain from smoking.. Perlutal ® has a transient inhibitory effect on ovulation, which does not lead to ...