Althesin information about active ingredients, pharmaceutical forms and doses by GlaxoSmithKline, Althesin indications, usages and related health products lists
Boeryd, B; Lundin, P; and Norrby, K, "Tumour growth after intravenous, intraperitoneal and subcutaneous injection of syngeneic monodispersed tumour-cell suspension." (1971). Subject Strain Bibliography 1971. 1706 ...
Looking for online definition of althesin in the Medical Dictionary? althesin explanation free. What is althesin? Meaning of althesin medical term. What does althesin mean?
TY - JOUR. T1 - Effect of body posture on cardiopulmonary function in horses during five hours of constant-dose halothane anesthesia. AU - Steffey, Eugene. AU - Kelly, A. B.. AU - Hodgson, D. S.. AU - Grandy, J. L.. AU - Woliner, M. J.. AU - Willits, N.. PY - 1990/3/23. Y1 - 1990/3/23. UR - http://www.scopus.com/inward/record.url?scp=0025266649&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0025266649&partnerID=8YFLogxK. M3 - Article. C2 - 2301808. AN - SCOPUS:0025266649. VL - 51. SP - 11. EP - 16. JO - American Journal of Veterinary Research. JF - American Journal of Veterinary Research. SN - 0002-9645. IS - 1. ER - ...
Intravenous anaesthetics 1.Thiopentone- agent of choice for neurosurgery - c/i in hypovolemia & shock - truth serum 2-Propofol- preferred agent for day care surgery - intravenous anaesthetic agent of choice in malignant hyperthermia - iv anaesthetic of choice for intubation 3-Etomidate- agent of choice for cardiovascular surgeries 4-Ketamine- dissociative anaesthesia -c/i in head injury , space occupying lesions - c/i hypertensive and ischaemic heart diseases - iv anaesthetic of choice in pt with shock and hypovolemia - iv anaesthetic of choice in asthmatic ...
The main goal of the pectus multicenter outcomes study is to document the utility of PEx repair in improving health and quality of life and to test the prevailing belief that the two predominant surgical procedures currently in use for PEx repair are essentially equivalent in terms of long-term outcomes.. We believe the uncertainty about the impact of PEx on cardiopulmonary function is due to part to the fact that the previous studies have not measured the physiological parameters mostly likely affected by the defect. A protocol to test this was developed. Thus, we propose to use these measures as well as conventional output of progressive exercise test to examine cardiopulmonary function before and after surgical repair of PEx within the context of the original study. ...
In order to provide the best care possible, C-O2 partners with the C-era and C-endo clinics to offer complete and comprehensive care.. ...
OBJECTIVE To determine the pharmacokinetics and pharmacodynamics of the neurosteroid anaesthetic, alfaxalone, in neonatal foals after a single intravenous (IV) injection of alfaxalone following premedication with butorphanol tartrate. STUDY DESIGN Prospective experimental study. ANIMALS Five clinically healthy Australian Stock Horse foals of mean ± SD age of 12 ± 3 days and weighing 67.3 ± 12.4 kg. METHODS Foals were premedicated with butorphanol (0.05 mg kg(-1) IV) and anaesthesia was induced 10 minutes later by IV injection with alfaxalone 3 mg kg(-1) . Cardiorespiratory variables (pulse rate, respiratory rate, direct arterial blood pressure, arterial blood gases) and clinical signs of anaesthetic depth were evaluated throughout anaesthesia. Venous blood samples were collected at strategic time points and alfaxalone plasma concentrations were assayed using liquid chromatography-mass spectrometry (LC/MS) and analysed by noncompartmental pharmacokinetic analysis. RESULTS The harmonic, mean ±
The binding affinities of two steroid anaesthetics, alphaxalone (Alfx) and alphadolone acetate (Alfd), for testosterone-oestradiol-binding globulin (TeBG) and corticosteroid-binding globulin (CBG)...
The hemodynamic effects of alfaxalone and propofol on the cardiovascular system during anesthetic maintenance in experimental medicine were investigated in pigs.
The major finding of the present study is that the inhibition of spontaneous firing of 5-HT cells in the rat DRN induced by systemic administration of risperidone is associated with, and probably caused by, increased 5-HT output within the DRN.. Based on the high affinity of risperidone for 5-HT2A receptors and less, but still relatively high, affinity for D2 receptors as shown with both ex vivo (Leysen et al., 1992; Schotte et al., 1996) and in vivo (Matsubara et al., 1993; Sumiyoshi et al., 1994) methods, the doses of risperidone used in the present study were selected to yield a high 5-HT2A receptor occupancy throughout the major part of the dose spectrum and a gradually increasing D2 receptor occupancy. Consequently, both antagonism of 5-HT2A and D2 receptors by risperidone could, theoretically, underlie the observed inhibition of 5-HT cell firing in the DRN. However, this explanation seems less likely since both the highly selective 5-HT2A receptor antagonist MDL 100,907 (Palfreyman et al., ...
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Practical imaging constraints restrict the number of wavelengths that can be measured in a single Biolumines- cence Tomography imaging session, but it is unclear which set of measurement wavelengths is optimal, in the sense of providing the most information about the bioluminescent source. Mutual Information was used to integrate knowledge of the type of bioluminescent source likely to be present, the optical properties of tissue and physics of light propagation, and the noise characteristics of the imaging system, in order to quantify the information contained in measurements at different sets of wavelengths. The approach was applied to a two-dimensional sim- ulation of Bioluminescence Tomography imaging of a mouse, and the results indicate that different wavelengths and sets of wavelengths contain different amounts of information. When imaging at a single wavelength, 580nm was found to be optimal, and when imaging at two wavelengths, 570nm and 580nm were found to be optimal. Examination of the ...
Patients with myasthenia gravis (MG) initially have their condition diagnosed and medically stabilized by a neurologist, who then refers the patient to our surgeons. The surgeon first arranges for the patient to have a computed tomography (CT) scan to look for a potential thymoma as MG has about a 25 percent chance of being associated with a thymoma. Based on the findings of this test and other factors, we work with the patient to determine the most appropriate surgical course of treatment.. Our divisions physicians are highly skilled in performing transcervical thymectomy and video-assisted thoracoscopy (VATS), two minimally invasive procedures for thymus removal. We also perform standard open (i.e. transsternal) procedures. Recently, robotic-assisted minimally invasive thymectomy has been introduced as an additional option for selected patients. We have an excellent track record with all techniques in terms of patient outcomes.. Following surgery, the patients neurologist will provide ...
Assessment of anaesthetic depth is vital for safe anaesthesia, and has traditionally been based on clinical signs including eye position, ocular and palpebral reflexes, changes in heart and respiratory rate, muscle tone and response to noxious stimuli (Guedel 1927, Gillespie 1943, Hall and others 2001). During inhalant anaesthesia, the eye is ventromedially rotated during light or moderate planes of anaesthesia, and is central during inadequate or excessively deep planes of anaesthesia (Guedel 1927, Hall and others 2001). The aim of this study was to determine the eye position of cats anaesthetised with alfaxalone (AFX) or propofol (PRO) to a sufficient depth to perform orotracheal intubation.. The study was approved by the University of Bristol Ethics Committee, and informed, written, owner consent was obtained. Healthy cats (American Society of Anesthesiologists physical status 1) presented for routine neutering were enrolled in the study. Cats were randomly allocated to receive either AFX or ...
Dogs are often placed under general anesthesia for diagnostic and surgical procedures. Aside from the well-known risks of anesthesia, such as heart or lung depression, anesthetic agents can also suppress immune function. This poorly understood phenomenon is especially important in dogs that may already suffer from immune compromise, such as those with critical illness or cancer. The role of commonly used anesthetic agents, such as ketamine and propofol, on immune function in patients with cancer is being investigated in laboratory animals and humans, with ketamine increasing the spread of cancer to the lungs in rats compared to propofol. Unfortunately, there is no current research in dogs comparing these two anesthetic agents. Additionally, a newer anesthetic agent, alfaxalone, is gaining popularity for use in both healthy and critically ill dogs, but there is no research available on the effects of alfaxalone on immune function in dogs. Given the lack of information of the immune effects of these three
Döbeli, Alexandra. Apgar score of dog puppies deliverd by cesarean section using alfaxalone or propofol for anesthesia induction. 2013, University of Zurich, Vetsuisse Faculty. ...
The Drug Enforcement Administration (DEA) proposes the placement of 5[alpha]-pregnan-3[alpha]-ol-11,20-dione (alfaxalone) including its salts, isomers, and salts of isomers whenever the existence of such salts, isomers, and salts of isomers is possible, into Schedule IV of the Controlled...
Phaxan™ is an intravenous general anaesthetic and sedative containing alphaxalone as the active pharmaceutical ingredient. Alphaxalone is a neuroactive steroid anaesthetic. It is a pregnanedione with no endocrine hormonal activity. This water-insoluble drug was initially formulated using CremophorEL and marketed as Althesin® from 1972 to 1984. It was found to be a safe and versatile intravenous anaesthetic used in clinical practice in anaesthesia and intensive care in many countries until it was withdrawn from clinical practice because of hypersensitivity to the CremophorEL.. Many subsequent attempts to make an aqueous formulations of neuroactive steroids suitable for human use have failed. Drawbridge Pharmaceuticals proprietary and patented formulation, Phaxan™, is a solution of alphaxalone 10mg/ml dissolved in 13% SBECD (7- sulfobutylether β-cyclodextrin); a molecule with a lipophilic cavity that enables drug dispersal in water for human use. The use of SBECD as the excipient preserves ...
Source: Pharmarket sales statistics 1-12/2019. Orion is a significant player also in the Scandinavian generics market.. According to IQVIA pharmaceutical sales statistics, in Europe total sales of the most common intravenous anaesthetics and intensive care sedatives (propofol, midazolam, remifentanil and dexmedetomidine) in the 12-month period ending in September 2019 were up by 4% at EUR 595 (570) million. The active ingredient in Orions Dexdor® intensive care sedative is dexmedetomidine. The total sales of dexmedetomidine wasEUR 72 (69) million in Europe, according to IQVIA pharmaceutical sales statistics... Published on 23 October 2019. Finland is the most important individual market for Orion, generating about one-third of the Groups net sales. According to Pharmarket statistics (1-9/2019), the total sales of Orions human pharmaceuticals, including both medicinal and non-medicinal products, was behind market trend. The growth in the Finnish pharmaceuticals market has mostly been ...
General anaesthetic can make the pain of operations worse for patients recovering after surgery by activating the bodys "mustard receptors", researchers have found. Many of the drugs that send surgical patients to sleep are known to make them more sensitive to pain when they wake up. Scientists now believe they have discovered the reason for the side effect. The findings may help researchers develop new anaesthetics that are kinder to recovering patients. General anaesthetics all suppress the central nervous system to cause unconsciousness and paralysis. But they can also activate "pain-sensing" cells in the peripheral nervous system, leading to post-operative discomfort. The new research focused on two of these pain receptors, TRPV1 and TRPA1, which often appear together and also react to irritants such as the chilli chemical capsaicin and mustard. Study leader Dr Gerard Ahern, from Georgetown University Medical Centre in Washington DC, said: "Plants produce chemicals such as capsaicin, ...
How is Diazepam and Methohexital (drug combination) abbreviated? D-M stands for Diazepam and Methohexital (drug combination). D-M is defined as Diazepam and Methohexital (drug combination) very rarely.
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Methohexital - Get up-to-date information on Methohexital side effects, uses, dosage, overdose, pregnancy, alcohol and more. Learn more about Methohexital
A Hysterectomy is a surgical procedure to remove the uterus from women. It is a major surgery that requires general anaesthetics, multiple days in hospital and weeks of rest and recovery.