TY - JOUR. T1 - Aldose reductase inhibition counteracts oxidative-nitrosative stress and poly(ADP-ribose) polymerase activation in tissue sites for diabetes complications. AU - Obrosova, Irina G.. AU - Pacher, Pal. AU - Szabo, Csaba. AU - Zsengeller, Zsuzsanna. AU - Hirooka, Hiroko. AU - Stevens, Martin J.. AU - Yorek, Mark A.. PY - 2005/1. Y1 - 2005/1. N2 - This study evaluated the effects of aldose reductase inhibition on diabetes-induced oxidative-nitrosative stress and poly(ADP-ribose) polymerase (PARP) activation. In animal experiments, control and streptozotocin-induced diabetic rats were treated with or without the aldose reductase inhibitor (ARI) fidarestat (16 mg· kg-1·day-1) for 6 weeks starting from induction of diabetes. Sorbitol pathway intermediate, but not glucose, accumulation in sciatic nerve and retina was completely prevented in diabetic rats treated with fidarestat. Sciatic motor nerve conduction velocity, hindlimb digital sensory nerve conduction velocity, and sciatic ...

ALCOHOL DEHYDROGENASE [NADP+](2s,4s)-2-aminoformyl-6-fluoro-spiro[chroman-4,4-imidazolidine]-2,5-dione2-monophosphoadenosine 5-diphosphoriboseFidarestatNadp Nicotinamide-adenine-dinucleotide Phosphate

Saccharomyces cerevisiae ferments hexoses efficiently but is unable to ferment xylose. When the bacterial enzyme xylose isomerase (XI) from Thermus thermophilus was produced in S. cerevisiae, xylose utilization and ethanol formation were demonstrated. In addition, xylitol and acetate were formed. An unspecific aldose reductase (AR) capable of reducing xylose to xylitol has been identified inS. cerevisiae. The GRE3gene, encoding the AR enzyme, was deleted in S.cerevisiae CEN.PK2-1C, yielding YUSM1009a. XI fromT. thermophilus was produced, and endogenous xylulokinase from S.cerevisiae was overproduced in S.cerevisiae CEN.PK2-1C and YUSM1009a. In recombinant strains from which the GRE3 gene was deleted, xylitol formation decreased twofold. Deletion of the GRE3 gene combined with expression of the xylA gene fromT. thermophilus on a replicative plasmid generated recombinant xylose utilizing S.cerevisiae strain TMB3102, which produced ethanol from xylose with a yield of 0.28 mmol of C from ...

We have characterised a novel aldo-keto reductase (AKR7A5) from mouse liver that is 78% identical to rat aflatoxin dialdehyde reductase AKR7A1 and 89% identical to human succinic semialdehyde (SSA) reductase AKR7A2. AKR7A5 can reduce 2-carboxybenzaldehyde (2-CBA) and SSA as well as a range of aldehyde and diketone substrates. Western blots show that it is expressed in liver, kidney, testis and brain, and at lower levels in skeletal muscle, spleen heart and lung. The protein is not inducible in the liver by dietary ethoxyquin. Immunodepletion of AKR7A5 from liver extracts shows that it is one of the major liver 2-CBA reductases but that it is not the main SSA reductase in this tissue.. ...

TY - JOUR. T1 - Erratum to Expression of rat aldehyde reductase AKR7A1: influence of age and sex and tissue-specific inducibility [Biochemical Pharmacology V.62 (2001) 1511-1519]. AU - Grant, Anne W.. AU - Staffas, Louise. AU - Mankowitz, Louise. AU - Kelly, Vincent P.. AU - Manson, Margaret M.. AU - DePierre, Joseph W.. AU - Hayes, John D.. AU - Ellis, E.M.. N1 - This is an erratum to Strathprint ID http://strathprints.strath.ac.uk/23620/. PY - 2002/7/15. Y1 - 2002/7/15. N2 - This is an erratum to Expression of rat aldehyde reductase AKR7A1: influence of age and sex and tissue-specific inducibility published in Biochemical Pharmacology vol 62 (2001) pages 1511-1519.. AB - This is an erratum to Expression of rat aldehyde reductase AKR7A1: influence of age and sex and tissue-specific inducibility published in Biochemical Pharmacology vol 62 (2001) pages 1511-1519.. KW - aldehyde reductase. KW - developmental regulation. KW - fetal expression. KW - sex-specific expression. KW - growth ...

Looking for online definition of C-type lectin domain family 3, member B in the Medical Dictionary? C-type lectin domain family 3, member B explanation free. What is C-type lectin domain family 3, member B? Meaning of C-type lectin domain family 3, member B medical term. What does C-type lectin domain family 3, member B mean?

As a member of the wwPDB, the RCSB PDB curates and annotates PDB data according to agreed upon standards. The RCSB PDB also provides a variety of tools and resources. Users can perform simple and advanced searches based on annotations relating to sequence, structure and function. These molecules are visualized, downloaded, and analyzed by users who range from students to specialized scientists.

In enzymology, aldose reductase (or aldehyde reductase) (EC 1.1.1.21) is a cytosolic NADPH-dependent oxidoreductase that catalyzes the reduction of a variety of aldehydes and carbonyls, including monosaccharides. It is primarily known for catalyzing the reduction of glucose to sorbitol, the first step in polyol pathway of glucose metabolism. Aldose reductase catalyzes the NADPH-dependent conversion of glucose to sorbitol, the first step in polyol pathway of glucose metabolism. The second and last step in the pathway is catalyzed by sorbitol dehydrogenase, which catalyzes the NAD-linked oxidation of sorbitol to fructose. Thus, the polyol pathway results in conversion of glucose to fructose with stoichiometric utilization of NADPH and production of NADH. glucose + NADPH + H+ ⇌ {\displaystyle \rightleftharpoons } sorbitol + NADP+ Galactose is also a substrate for the polyol pathway, but the corresponding keto sugar is not produced because sorbitol dehydrogenase is incapable of oxidizing ...

The aim of this study was to identify the cardiac oxidoreductases involved in the metabolism of 4-hydroxy-2-trans-nonenal (HNE), an α,β unsaturated aldehyde generated during the peroxidation of ω-6 polyunsaturated fatty acids. In homogenates of bovine, human and rat ventricles the primary pyridine coenzyme-linked metabolism of HNE was associated with NADPH oxidation. The NADPH-dependent enzyme catalysing HNE reduction was purified to homogeneity from bovine heart. The purified enzyme displayed kinetic and immunological properties identical with the polyol pathway enzyme aldose reductase (AR), and catalysed the reduction of HNE to its alcohol 1,4-dihydroxynonene (DHN), with a Km of 7±2 μM. In the presence of NADP the enzyme did not catalyse the oxidation of DHN. During catalysis, HNE did not cause inactivation of AR. Nevertheless when the apoenzyme was incubated with HNE a dissociable complex was formed between the enzyme and HNE, followed by irreversible loss of activity. Inactivation of ...

TY - JOUR. T1 - Progression of sugar cataract in the dog.. AU - Sato, S.. AU - Takahashi, Y.. AU - Wyman, M.. AU - Kador, P. F.. PY - 1991/5. Y1 - 1991/5. N2 - Young beagle dogs were fed a 30% galactose diet, with or without the aldose reductase inhibitors sorbinil or M79175. Cataract formation was monitored by indirect ophthalmoscope and hand-held slit-lamp microscopy and documented by retroillumination photography. In these dogs, the first sign of cataract development was an accentuation of the anterior and posterior lens sutures (1 month after feeding), then the appearance of cortical vacuoles (3 months after feeding), and finally, the formation of predominantly equatorial cortical opacities toward the posterior cortices (4-6 months after feeding). After long-term galactose feeding, a progressive, irregular, clear zone formed at the cortical equatorial regions. Light microscopic examination of these lenses shows that the cataracts are osmotic, many of the lens fibers appear to be swollen or ...

Evidence-Based Complementary and Alternative Medicine (eCAM) is an international peer-reviewed, Open Access journal that seeks to understand the sources and to encourage rigorous research in this new, yet ancient world of complementary and alternative medicine.

Although the enhanced activity of the polyol pathway has been detected in diabetic glomeruli, the intraglomerular localization of this pathway has not yet been well defined. In this study, we attempted to identify aldose reductase, a key enzyme of the polyol pathway, in cultured rat mesangial cells and to characterize the properties of this enzyme using enzymological and immunological methods. When the aldose reductase (DL-glyceraldehyde-reducing) activity was analyzed in mesangial cell extract, the Lineweaver-Burk plot showed concave downward curvature, and the Michaelis constant was 0.83 mM DL-glyceraldehyde, and this activity was noncompetitively inhibited by an aldose reductase inhibitor, ICI-128,436. The enzyme activity was enhanced by the addition of sulfate ion and partially suppressed by barbital. The enzyme cross-reacted with the antisera against rat lens and testis aldose reductases on Ouchterlony plate, and migrated to the region of molecular weight of about 36,500 Da on Western ...

TY - JOUR. T1 - Catalytic reaction profile for NADH-dependent reduction of aromatic aldehydes by xylose reductase from Candida tenuis.. AU - Mayr, P.. AU - Nidetzky, Bernd. PY - 2002. Y1 - 2002. UR - http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12003638. M3 - Article. VL - 366. SP - 889. EP - 899. JO - Biochemical Journal. JF - Biochemical Journal. SN - 0264-6021. IS - 3. ER - ...

Also called the sorbitol-aldose reductase pathway, the polyol pathway is a two-step process that converts glucose to fructose. In this pathway glucose is reduced to sorbitol, which is subsequently oxidized to fructose. The pathway is implicated in diabetic complications, especially in microvascular damage to the retina, kidney, and nerves. Sorbitol cannot cross cell membranes, and, when it accumulates, it produces osmotic stresses on cells by drawing water into the insulin-independent tissues. Cells use glucose for energy. This normally occurs by phosphorylation via the enzyme hexokinase. However, if large amounts of glucose are present (as in diabetes mellitus), hexokinase becomes saturated and the excess glucose enters the polyol pathway when aldose reductase reduces it to sorbitol. This reaction oxidizes NADPH to NADP+. Sorbitol dehydrogenase can then oxidize sorbitol to fructose, which produces NADH from NAD+. Hexokinase can return the molecule to the glycolysis pathway by phosphorylating ...

TY - JOUR. T1 - Epalrestat induces cell proliferation and migration in endothelial cells via mTOR activation through PI3/Akt signaling. AU - Suzuki, Kunihiro. AU - Tanaka, Seiichi. AU - Yanagi, Kazunori. AU - Iijima, Tosie. AU - Niitani, Mai. AU - Coletta, Ciro. AU - Szabo, Csaba. AU - Aso, Yoshimasa. PY - 2014/6. Y1 - 2014/6. N2 - Angiogenesis is a major physiological response to ischemia that involves development of new capillaries and collateral circulation from preexisting vessels, and endothelial cell (EC) proliferation and migration are crucial events for this process. Epalrestat, an aldose reductase inhibitor, is used as a therapeutic agent for the treatment of diabetic peripheral neuropathy. We examined the effect of epalrestat on the proliferation and migration of a mouse microvascular endothelial cell line (bEnd3 cells) measured by scratch wound assay and cell proliferation assay. Epalrestat significantly enhanced the proliferation and migration of bEnd3 cells. The addition of ...

Deloukas P, Earthrowl ME, Grafham DV, Rubenfield M, French L, Steward CA, Sims SK, Jones MC, Searle S, Scott C, Howe K, Hunt SE, Andrews TD, Gilbert JG, Swarbreck D, Ashurst JL, Taylor A, Battles J, Bird CP, Ainscough R, Almeida JP, Ashwell RI, Ambrose KD, Babbage AK, Bagguley CL, Bailey J, Banerjee R, Bates K, Beasley H, Bray-Allen S, Brown AJ, Brown JY, Burford DC, Burrill W, Burton J, Cahill P, Camire D, Carter NP, Chapman JC, Clark SY, Clarke G, Clee CM, Clegg S, Corby N, Coulson A, Dhami P, Dutta I, Dunn M, Faulkner L, Frankish A, Frankland JA, Garner P, Garnett J, Gribble S, Griffiths C, Grocock R, Gustafson E, Hammond S, Harley JL, Hart E, Heath PD, Ho TP, Hopkins B, Horne J, Howden PJ, Huckle E, Hynds C, Johnson C, Johnson D, Kana A, Kay M, Kimberley AM, Kershaw JK, Kokkinaki M, Laird GK, Lawlor S, Lee HM, Leongamornlert DA, Laird G, Lloyd C, Lloyd DM, Loveland J, Lovell J, McLaren S, McLay KE, McMurray A, Mashreghi-Mohammadi M, Matthews L, Milne S, Nickerson T, Nguyen M, Overton-Larty ...

Yeast cells are transformed with an exogenous xylose isomerase gene. Additional genetic modifications enhance the ability of the transformed cells to ferment xylose to ethanol or other desired fermentation products. Those modifications, include deletion of non-specific or specific aldose reductase gene(s), deletion of xylitol dehydrogenase gene(s) and/or overexpression of xylulokinase.

Carpinus tschonoskii (CT) has been previously studied for various activities in the improvement of skin diseases. In the present study, we examined the in vitro anti-acne vulgaris (AV) effect of CT leaves (CTL) and tellimagrandin I (TI), one of the main ellagitannins from CT, including skin barrier improvement and 5α-reductase inhibitory activity. To test the anti-AV activities of CTL and TI, firstly, anti-oxidative and anti-inflammatory activities including DPPH radical scavenging activity, nitric oxide (NO) inhibitory activity, and cytokines [interleukin (IL)-6 and IL-8] were tested. Skin barrier improvement experiments were tested using developing cornified envelope (CE) formation, and filaggrin mRNA expression level was determined by RT-PCR. The 5α-reductase inhibitory activity was determined by measuring the testosterone levels in rat liver microsomes. CTL and TI showed potent anti-oxidative activity and anti-inflammatory activities. Especially, the cytokine production inhibitory activities of TI

Recent studies revealed that Tonicity-responsive enhancer binding protein (TonEBP) directly regulates the transcription of aldose reductase (AR), which catalyzes the first step of the polyol pathway of glucose metabolism. Activation of protein kinase C δ (PKCδ) is dependent on AR and it has been linked to diabetic complications. However, whether TonEBP affects expressions of AR and PKCδ in diabetic retinopathy was not clearly shown. In this study, we used TonEBP heterozygote mice to study the role of TonEBP in streptozotocin (STZ)-induced diabetic retinopathy. We performed immunofluorescence staining and found that retinal expressions of AR and PKCδ were significantly reduced in the heterozygotes compared to wild type littermates, particularly in ganglion cell layer. To examine further the effect of TonEBP reduction in retinal tissues, we performed intravitreal injection of TonEBP siRNA and confirmed the decrease in AR and PKCδ levels. In addition, we found that a proapoptotic factor, Bax ...

Whilst this may not always ensure that diabetic neuropathy will not occur or progress, there is adequate evidence to show that optimal management of the blood glucose levels is of significant importance. More over there is some evidence that as much as the plasma glucose levels, wide fluctuations in these levels is also very detrimental to the nerves.. Aldose reductase inhibitors, a-Lipoic acid, ?-Linolenic acid have been used with varying results, especially the last two. Aldose reductase inhibitors did not live up to their supposed potential to treat diabetic neuropathy. Injections of B1, B6, and B12 are routinely used by many doctors when faced with a patient with diabetic neuropathy. Unless there is manifest evidence of the deficiency of these vitamins in the patient, the injections would be of use only as a placebo.. ...

The development of cataracts in patients suffering from diabetes can lead to blindness at late stages of the disease. The polyol pathway, advanced glycation end products (AGEs), and oxidative stress have all been implicated in the development of DC [55-58]. Lens epithelial cells (LECs) are damaged in diabetic cataractogenesis, which can be induced by ultraviolet radiation, oxidative stress, and hyperglycemia [59-61]. Apoptosis of LECs occurs during cataract formation, and, as such, inhibiting apoptosis can prevent or delay this process [60, 62]. AR catalyzes the conversion of glucose to sorbitol via the polyol pathway, a process involved in diabetic cataract formation [63-67]. Extensive research has demonstrated that the AR pathway is the initiating step in diabetic cataract formation. Intracellular accumulation of sorbitol leads to osmotic changes resulting in hydropic lens fibers that degenerate and form sugar cataracts [68, 69]. There are several factors leading to the accumulation of ...

0297] The following references, to the extent that they provide exemplary procedural or other details supplementary to those set forth herein, are specifically incorporated herein by reference. [0298] U.S. Pat. No. 4,130,714 [0299] U.S. Pat. No. 4,251,528 [0300] U.S. Pat. No. 4,436,745 [0301] U.S. Pat. No. 4,438,272 [0302] U.S. Pat. No. 4,464,382 [0303] U.S. Pat. No. 4,540,704 [0304] U.S. Pat. No. 4,600,724 [0305] U.S. Pat. No. 4,734,419 [0306] U.S. Pat. No. 4,771,050 [0307] U.S. Pat. No. 4,791,126 [0308] U.S. Pat. No. 4,831,045 [0309] U.S. Pat. No. 4,883,410 [0310] U.S. Pat. No. 4,883,800 [0311] U.S. Pat. No. 4,980,357 [0312] U.S. Pat. No. 5,037,831 [0313] U.S. Pat. No. 5,066,659 [0314] U.S. Pat. No. 5,252,572 [0315] U.S. Pat. No. 5,270,342 [0316] U.S. Pat. No. 5,354,855 [0317] U.S. Pat. No. 5,430,060 [0318] U.S. Pat. No. 5,447,946 [0319] U.S. Pat. No. 5,582,981 [0320] U.S. Pat. No. 5,756,291 [0321] U.S. Pat. No. 5,780,610 [0322] U.S. Pat. No. 5,792,613 [0323] U.S. Pat. No. 5,840,867 [0324] ...

Giant cell arteritis (GCA) is a systemic vasculitis preferentially affecting large and medium-sized arteries. Inflammatory infiltrates in the arterial wall induce luminal occlusion with subsequent ischemia and degradation of the elastic membranes, allowing aneurysm formation. To identify pathways relevant to the disease process, differential display-PCR was used. The enzyme aldose reductase (AR), which is implicated in the regulation of tissue osmolarity, was found to be upregulated in the arteritic lesions. Upregulated AR expression was limited to areas of tissue destruction in inflamed arteries, where it was detected in T cells, macrophages, and smooth muscle cells. The production of AR was highly correlated with the presence of 4-hydroxynonenal (HNE), a toxic aldehyde and downstream product of lipid peroxidation. In vitro exposure of mononuclear cells to HNE was sufficient to induce AR production. The in vivo relationship of AR and HNE was explored by treating human GCA temporal artery-severe ...

The aldose reductase reaction, in particular the sorbitol produced, is important for the function of various organs in the body. For example, it is generally used as the first step in a synthesis of fructose from glucose; the second step is the oxidation of sorbitol to fructose catalyzed by sorbitol dehydrogenase. The main pathway from glucose to fructose (glycolysis) involves phosphorylation of glucose by hexokinase to form glucose 6-phosphate, followed by isomerization to fructose 6-phosphate and hydrolysis of the phosphate, but the sorbitol pathway is useful because it does not require the input of energy in the form of ATP: ...

We report that a highly selective ARI with novel structure, given at a dose that inhibited retinal polyol accumulation in diabetes, was well tolerated in diabetic rats and prevented or reversed multiple early effects of diabetes on neural, glial, and vascular cells of the retina. These results confirm and extend our previous findings with sorbinil (1,9), an ARI of a different structural class and a less selective inhibitor of aldose reductase. The data are also consistent with recent evidence that deletion of the gene for aldose reductase prevents retinal abnormalities triggered by diabetes in db/db mice (2), and they are supportive of the genetic data linking aldose reductase alleles associated with elevated expression of the protein to higher risk for development of diabetic retinopathy in humans (19). Although each of these different types of data has potential limitations when taken individually (e.g., unsuspected off-target effects in the drug studies, unknown but functionally meaningful ...

Aldo-keto reductase family 1 member C1 also known as 20α-hydroxysteroid dehydrogenase, 3α-hydroxysteroid dehydrogenase, and dihydrodiol dehydrogenase 1/2 is an enzyme that in humans is encoded by the AKR1C1 gene.[1][2] This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reduction of progesterone to the inactive form 20-alpha-hydroxy-progesterone. This gene shares high sequence identity with three other gene members, and is clustered with those three genes at chromosome 10p15-p14.[2] ...

DNAJB5 (DnaJ heat shock protein family (Hsp40) member B5), Authors: Dessen P. Published in: Atlas Genet Cytogenet Oncol Haematol.

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TY - JOUR. T1 - Identification of a renal-specific oxido-reductase in newborn diabetic mice. AU - Yang, Qiwei. AU - Dixit, Bharat. AU - Wada, Jun. AU - Tian, Yufeng. AU - Wallner, Elisabeth I.. AU - Srivastva, Satish K.. AU - Kanwar, Yashpal S.. PY - 2000/8/29. Y1 - 2000/8/29. N2 - Aldose reductase (ALR2), a NADPH-dependent aldo-keto reductase (AKR), is widely distributed in mammalian tissues and has been implicated in complications of diabetes, including diabetic nephropathy. To identify a renal-specific reductase belonging to the AKR family, representational difference analyses of cDNA from diabetic mouse kidney were performed. A full-length cDNA with an ORF of 855 nt and yielding a ≃ 1.5-kb mRNA transcript was isolated from a mouse kidney library. Human and rat homologues also were isolated, and they had ≃ 91% and ≃ 97% amino acid identity with mouse protein. In vitro translation of the cDNA yielded a protein product of ≃ 33 kDa. Northern and Western blot analyses, using the cDNA and ...

aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III ...

SWISS-MODEL Repository entry for A0A0B4GT47 (ARP2_METAF), Hydroxynaphthalene reductase-like protein Arp2. Metarhizium anisopliae (strain ARSEF 549)

The IUPHAR/BPS Guide to Pharmacology. tolrestat ligand page. Quantitative data and detailed annnotation of the targets of licensed and experimental drugs.

Many aldehydes such as furfural are present in high quantities in lignocellulose lysates and are fermentation inhibitors that make biofuel production from this abundant carbon source extremely challenging. Cbei_3974 has recently been identified as an aldo-keto reductase responsible for partial furfural resistance in Clostridium beijerinkii. Rational engineering of this enzyme could enhance the furfural tolerance of this organism thereby improving biofuel yields. We report an extensive characterization of Cbei_3974 and a single crystal X-ray structure of Cbei_3974 in complex with NADPH at a resolution of 1.75 Å. Docking studies identified residues involved in substrate binding and an activity screen revealed the substrate tolerance of the enzyme. Hydride transfer, which is partially rate limiting under physiological conditions, occurs from the pro-R hydrogen of NADPH. Enzyme isotope labeling revealed a temperature-independent enzyme isotope effect of unity, indicating that the enzyme does not ...

In recent years, efforts are being made to search for new molecules from the natural sources and in this endeavour diaryl heptanoids, oxygenated abietanes, diterpene quinones are showing promise as new lead molecules. Randomly designed heterocyclic ionone like molecules [Anzaldi M., Sottofattori E., Rizzetto R, di Casaleto B. G., Balbi A., Eur. J. Med. Chem. (1999), 34, 837] and some novel terpenyl 2, 4-diamino pyrimidines [Rosowsky A., Papoulis A. T., Queener S. F., J. Heterocyclic Chem.(1999), 36 723] are showing promising antimicrobial and dihydrofolate reductase inhibitory activities. Rationally designed 2, 4-diaminopyrimidines and some computer aided molecules are also giving further inputs in the leishmanial dihydrofolate reductase activity. In continuation of our studies on terpenyl pyrimidines as novel antileishmanial agents [Pandey S, Suryawanshi S. N., Gupta S, Srivastava V. M. L., Eur. J. Med. Chem. (2004), 39, 969], we have designed novel terpenyl Isooxazoles for their in-vivo ...

An open study on the pharmacokinetics of lovastatin was conducted in six patients with chronic renal failure (mean creatinine clearance, 0.40 ml/sec; range, 0.20 to 0.65 ml/sec) and seven healthy subjects. Plasma levels of 3-hydroxy-3-methylglutaryl-coenzyme reductase inhibitory activity (total and …

You may return most new, unopened items within 30 days of delivery for a full refund. Well also pay the return shipping costs if the return is a result of our error (you received an incorrect or defective item, etc.).. You should expect to receive your refund within four weeks of giving your package to the return shipper, however, in many cases you will receive a refund more quickly. This time period includes the transit time for us to receive your return from the shipper (5 to 10 business days), the time it takes us to process your return once we receive it (3 to 5 business days), and the time it takes your bank to process our refund request (5 to 10 business days).. If you need to return an item, simply login to your account, view the order using the Complete Orders link under the My Account menu and click the Return Item(s) button. Well notify you via e-mail of your refund once weve received and processed the returned item.. ...

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The worlds first wiki where authorship really matters. Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts.

So I just got a marketing email from william hartfield touting the benefits of ecklonia cava for hairloss stating that In fact, its inhibitory effect was si

can be subdivided into two group with closer relationships within each group than between the groups; the first three families form one group whereas the last two families form the other group ...

For dogs with severe flu, treatment is more involved and requires hospitalization. Depending on the dogs condition and on which secondary complications are present, treatment can include supportive care, powerful broad-spectrum antibiotics (for severe forms of pneumonia) and IV fluids (for dehydration) [source: PetMD].. The severe form can be fatal, but its not technically the flu that causes death. Its a secondary complication, usually pneumonia [source: AVMA].. Overall, fatality rates for dog flu are pretty low. (They were much higher in the initially exposed racing greyhounds - 36 percent at one track -- than they are in the pet population [source: Iowa State].) According to most sources, 1 percent to 5 percent of infected dogs die, though some say its as high as 8 percent [sources: VCA, Iowa State].. Of course, when were talking about beloved pets, even 1 percent is a lot. There are things you can do to minimize your dogs risk, though, the most obvious being to vaccinate. But ...

INTRODUCTION It has been shown that diabetes predisposes the patient for neuropsychiatric deficits as stroke, cerebrovascular diseases, diabetic encephalopathy, depression and anxiety (Kuhad & Chopra, 2007). Diabetic encephalopathy, characterized by impaired cognitive functions and neurochemical and structural abnormalities, involves direct neuronal damage caused by intracellular glucose (Kuhad & Chopra). Primary diabetic encephalopathy may cause by hyperglycemia and impaired insulin action diabetes. In contrast, secondary diabetic encephalopathy appears to arise from hypoxic-ischemic insults due to underlying microvascular disease or as a consequence of hypoglycemia (Sima et al., 2004). The hippocampal formation plays an important role in spatial navigation and the formation of certain types of memories (Sneider et al., 2006). Subregional models of hippocampal function suggest that CA1 function is critical in correctly identifying novel relationships among objects within a particular spatial ...

polialcohol (es); Poliol (eu); многоатомный спирт (ru); Polyole (de-ch); Polyole (de); polyol (en-gb); پلی‌ال (fa); 糖醇 (zh); Poliol (tr); 糖アルコール (ja); flervärdig alkohol (sv); Багатоатомні спирти (uk); 糖醇 (zh-hant); 糖醇 (zh-cn); Polyoli (fi); Көпатомды спирттер (kk); Polyol (en-ca); polyol (cs); poliolo (it); polyol (fr); шмататамны сьпірт (be-tarask); Polyol (nl); Polyol (vi); poliol (pt); Daudzvērtīgie spirti (lv); 폴리올 (ko); Poliol (sr); Poliol (sl); poliolo (eo); 糖醇 (zh-hk); 糖醇 (zh-sg); Poliol (id); alkohol polihydroksylowy (pl); polyol (nb); 糖醇 (zh-tw); Բազմատոմ սպիրտներ (hy); fleirverdig alkohol (nn); polialcohol (ca); Poliol (ms); polyol (en); بوليول (ar); 糖醇 (zh-hans); Poliol (ro) çoklu hidroksil gruplarını içeren bir organik bileşik (tr); Composé organique (fr); alkohol med fler än en OH-grupp (sv); każdy alkohol zawierający więcej ...

Polyol Products from Chinese suppliers. ECVV.com provides Polyol product China Sourcing Agent service and supply chain service to protect the product quality and payment security.

Polyol R3430 is a trifunctional liquid polyol, used as a precursor for free radical radiation curing monomers and oligomers. Polyol R3430 is also used as a chemical building block and as crosslinker in polyurethanes.

ptr:464931 K00128 aldehyde dehydrogenase (NAD+) [EC:1.2.1.3] , (RefSeq) ALDH1B1; aldehyde dehydrogenase 1 family member B1 (A) MLRFLAPRLLSLQGRTARYSSVAALPSPILNPDIPYNQLFINNEWQDAVSKKTFPTVNPT TGEVIGHVAEGDRADVDRAVKAAREAFRLGSPWRRMDASERGRLLNRLADLVERDRVYLA SLETLDNGKPFQESYALDLDEVIKVYRYFAGWADKCHGKTIPMDGQHFCFTRHEPVGVCG QIIPWNFPLVMQGWKLAPALATGSTVVMKVAEQTPLSALYLASLIKEAGFPPGVVNIITG YGPTAGAAIAQHMDVDKVAFTGSTEVGHLIQKAAGDSNLKRVTLELGGKSPSIVLADADM EHAVEQCHEALFFNMGQCCCAGSRTFVEESIYNEFLERTVEKAKQRKVGNPFELDTQQGP QVDKEQFERVLGYIQLGQKEGAKLLCGGERFGERGFFIKPTVFGGVQDDMRIAKEEIFGP VQPLFKFKKIEEVIERANNTRYGLAAAVFTRDLDKAMYFTQALQAGTVWVNTYNIVTCHT PFGGFKESGNGRELGEDGLKAYTEVKTVTIKVPQKNS ...

Recombinant fragment, corresponding to amino acids 650-920 of Human Androgen Receptor including the Ligand Binding domain with a FLAG-tag on the N-terminus and a 8X His-tag on the C-terminus, expressed in a baculovirus system, 32kDa.

Complete information for ALDH3B1 gene (Protein Coding), Aldehyde Dehydrogenase 3 Family Member B1, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium

Complete information for ALDH3B2 gene (Protein Coding), Aldehyde Dehydrogenase 3 Family Member B2, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium

TY - JOUR. T1 - Effect of an aldose reductase inhibitor on alveolar bone loss associated with periodontitis in diabetic rats. AU - Kador, Peter F.. AU - Hamada, Tomofumi. AU - Reinhardt, Richard A.. AU - Blessing, Karen. PY - 2010/5/1. Y1 - 2010/5/1. N2 - Periodontitis is a lesser known but frequent complication of diabetes mellitus and is the major cause of tooth loss in patients with diabetes. Dental therapy for this complication is primarily focused on the control of oral infections. No current therapy directly addresses the potential effects of diabetes itself on this complication. In studies conducted in young normal control and streptozotocin diabetic rats (100 g) treated with and without the aldose reductase inhibitor (ARI) imirestat, experimental periodontitis was induced in one side of the mouth by 3 injections of lipopolysaccharide (LPS) from Escherichia coli 055:B5 9 into the palatal gingiva between the first and second maxillary molars at 48-hour intervals. The other control side was ...

Lipid peroxidation-derived aldehydes (LP-DA) can propagate oxidative injury and are detoxified by the aldose reductase (AR) enzyme pathway in myocardium. Whether there are alterations in the AR axis in heart failure (HF) is unknown. Sixteen instrumented dogs were studied before and after either 24 h or 4 wk of rapid left ventricular (LV) pacing (early and late HF, respectively). Six unpaced dogs served as controls. In early HF, there was subtle depression of LV performance (maximum rate of LV pressure rise, P < 0.05 vs. baseline) but no chamber enlargement, whereas in late HF there was significant (P < 0.05) contractile depression and LV dilatation. Oxidative stress was increased at both time points, indexed by tissue malondialdehyde, total glutathione, and free C6-C9 LP-DA (P < 0.025 vs. control). AR protein levels and activity decreased progressively during HF (P < 0.025 early/late HF vs. control); however, AR mRNA expression decreased only in late HF (P < 0.005 vs. early HF and control). DNA ...

Converts progesterone to its inactive form, 20-alpha-dihydroxyprogesterone (20-alpha-OHP). In the liver and intestine, may have a role in the transport of bile. May have a role in monitoring the intrahepatic bile acid concentration. May play a role in myelin formation. Can oxidize both 20-alpha- and 3-alpha-hydroxysteroids.

Accepted name: D-xylose reductase. Reaction: xylitol + NAD(P)+ = D-xylose + NAD(P)H + H+ Other name(s): XylR; XyrA; msXR; dsXR; monospecific xylose reductase; dual specific xylose reductase; NAD(P)H-dependent xylose reductase; xylose reductase. Systematic name: xylitol:NAD(P)+ oxidoreductase. Comments: Xylose reductase catalyses the initial reaction in the xylose utilization pathway, the NAD(P)H dependent reduction of xylose to xylitol. Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: References:. 1. Neuhauser, W., Haltrich, D., Kulbe, K.D. and Nidetzky, B. NAD(P)H-dependent aldose reductase from the xylose-assimilating yeast Candida tenuis. Isolation, characterization and biochemical properties of the enzyme. Biochem. J. 326 (1997) 683-692. [PMID: 9307017]. 2. Nidetzky, B., Bruggler, K., Kratzer, R. and Mayr, P. Multiple forms of xylose reductase in Candida intermedia: comparison of their functional properties using quantitative structure-activity ...

A large number of studies have documented the evidence that progression of diabetes leads to various secondary diabetic complications among which nephropathy is a serious complication with an increasing prevalence worldwide [22]. The nephropathy disease is characterized by morphological and ultra structural changes in the kidney including expansion of the molecular matrix. Even though, the pathogenesis of diabetic nephropathy is complex and still not fully elucidated, few biochemical changes such as increase in polyol pathway flux, increased AGEs formation, have been actively studied for their role in the development of diabetic nephropathy. Increased matrix proteins leading to decreased GFR is considered as a marker for the progression of the Diabetic nephropathy disease. Elevation of serum creatinine levels and BUN in diabetic rats is used as an index of altered GFR in diabetic nephropathy [23].. Results of the present study have corroborated with the previous reports in which administration ...

BioAssay record AID 185258 submitted by ChEMBL: Percent inhibition of sorbitol accumulation in the sciatic nerve of streptozotocin (STZ)- induced diabetic rats at peroral dose of 30 mg/kg (preventive effect).

Two enzymes are involved in the polyol pathway: an aldose reductase that reduces glucose in sorbitol followed by its oxidation in fructose by sorbitol dehydrogenase. It has been previously shown that both enzymes are presented in the bovine epididymis, where they are associated with membranous vesic …

The major focus of our research is to elucidate the mechanisms by which oxidative stress affects cardiovascular function. In particular, we are interested in the role of lipid peroxidation as a contributor to myocardial ischemic injury and atherosclerosis. Although lipid peroxidation generates several reactive intermediates and end products, lipid-derived unsaturated aldehydes are believed to be a major source of oxidative stress and these toxicants appear to be critical mediators of tissue injury due to lipid peroxidation. In order to understand how the cardiovascular tissues protect themselves from the toxic products of lipid peroxidation, we are currently investigating the biochemical mechanisms by which unsaturated aldehydes are detoxified in the heart and blood vessels. We have learned that the enzymes - aldose reductase, glutathione S-transferases and aldehyde dehydrogenase are the major constituents of aldehyde metabolism in the heart, and vascular smooth muscle and endothelial cells, and ...

Aldose reductase (AR), a NADPH-dependent enzyme, converts glucose to sorbitol associated with increasing oxidative stress. Sorbitol accumulates inside the tissues, as it cannot permeate to cell membranes, leading to ionic imbalance and protein insolubilization, consequently causes chronic diabetic complications. Recently, AR was strongly suggested to regulate cell proliferation, apoptosis and atherothrombosis in normal glucose condition. Platelets, anucleate cells, play a crucial role in hemostatic processes and arterial thrombosis. Collagen and thrombin induce platelet activation via binding to integrin α2β1 and glycoprotein (GP)VI, and protease-activated receptors (e.g., PAR1 and PAR4), respectively, and these receptors mediate distinct signals in platelet activation. Furthermore, the Ras superfamily (e.g., ADP-ribosylation factor, Arfs) appears to link platelet activation. Among the Arfs family, Arf6, a membrane bound enzyme is reported to play a key element in early platelet activation; ...

Buy FAM3B elisa kit, Monkey Family With Sequence Similarity 3, Member B ELISA Kit-AAQ88824.1 (MBS019535) product datasheet at MyBioSource, ELISA Kits

TY - JOUR. T1 - Ascorbic acid reverses the prolonged anesthetic action of pentobarbital in Akr1a-knockout mice. AU - Ito, Junitsu. AU - Otsuki, Noriyuki. AU - Zhang, Xuhong. AU - Konno, Tasuku. AU - Kurahashi, Toshihiro. AU - Takahashi, Motoko. AU - Yamato, Mayumi. AU - Matsuoka, Yuta. AU - Yamada, Ken-Ichi. AU - Miyata, Satoshi. AU - Fujii, Junichi. PY - 2014/1/24. Y1 - 2014/1/24. N2 - Aims Aldehyde reductase (AKR1A), a member of the aldo-keto reductase superfamily, is highly expressed in the liver and is involved in both the detoxification of carbonyl compounds and ascorbic acid biosynthesis. By comparison with wild-type mice, Akr1a-knockout (Akr1a-/-) mice and human Akrla-transgenic (Akr1atg/+) mice experience different anesthetic actions from pentobarbital - prolonged in Akr1a-knockout (Akr1a -/-) mice and shortened in human Akrla-transgenic (Akr1a tg/+) mice. Main methods We investigated this alteration in the anesthetic efficacy of pentobarbital in Akr1a genetically modified mice. Key ...

Hydroxybutyrate (GHB) is an endogenous metabolite synthesized in the brain. There is strong evidence to suggest that GHB has an important role as a neurotransmitter or neuromodulator.. The human aldo-keto reductase AKR7A2 has been proposed previously to catalyze the NADPH-dependent reduction of succinic semialdehyde (SSA) to GHB in human brain. In this study we have used RNA interference to evaluate the role of AKR7A2 in GHB biosynthesis in human neuroblastoma SH-SY5Y cells. Quantitative reverse transcription-PCR analysis and immunoblotting revealed that short interfering RNA molecules directed against AKR7A2 led to a significant reduction in both AKR7A2 transcript and protein levels 72 h post-transfection. We have shown that reduced expression of AKR7A2 results in a 90% decrease in SSA reductase activity of cell extracts. Furthermore, we have shown using gas chromatography-mass spectrometry that a decrease in the level of AKR7A2 was paralleled with a significant reduction in intracellular GHB ...

Looking for online definition of aldose in the Medical Dictionary? aldose explanation free. What is aldose? Meaning of aldose medical term. What does aldose mean?

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Subsequently, we set out to determine whether Zn2+ supplementation increases erythritol synthesis by the engineered Y. lipolytica. In this experiment we compared AMM pAD-YlER strain harboring the overexpression cassette with its parental strain MK1. The strains were grown in baffled flasks in medium developed for erythritol synthesis, supplemented with 0.25 mM ZnSO4 × 7H2O. Interestingly, we noted a strong increase in erythritol titer for both of the strains, the engineered and the control strain (Fig. 2b). The erythritol titer was improved by 22 and 37% for the engineered (54.1 g/L) and the control strain (51.0 g/L), respectively, when compared to the results obtained in medium without zinc supplementation (Fig. 2a). In addition, for the engineered strain we noted an increase in YERY, which achieved 0.55 g/L/h. Interestingly, a significant difference was observed for the control, which achieved an erythritol titer (51.0 g/L) at a similar level to the engineered strain (44.4 g/L) in medium ...

An enzyme that catalyzes reversibly the oxidation of an aldose to an alditol. It possesses broad specificity for many aldoses. EC 1.1.1.21 ...

1 Answer (question resolved) - Posted in: peripheral neuropathy, diabetic neuropathy - Answer: Long-term treatment with epalrestat is well tolerated ...

This gene encodes a member of the uridine diphosphoglucuronosyltransferase protein family. The encoded enzyme catalyzes the transfer of glucuronic acid from uridine diphosphoglucuronic acid to a diverse array of substrates including steroid hormones and lipid-soluble drugs. This process, known as glucuronidation, is an intermediate step in the metabolism of steroids. Copy number variation in this gene is associated with susceptibility to osteoporosis.[provided by RefSeq, Apr 2010 ...

p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.,/p> ,p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.,/p> ,p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).,/p> ,p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x,sup>64,/sup> + x,sup>4,/sup> + x,sup>3,/sup> + x + 1. The algorithm is described in the ISO 3309 standard. ,/p> ,p class=publication>Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.,br /> ,strong>Cyclic redundancy and other checksums,/strong>,br /> ,a href=http://www.nrbook.com/b/bookcpdf.php>Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993),/a>),/p> Checksum:i ...

on May 11, 2017. 2 cases of the lethal form of dwarfism - Thanatophoric dwarfism detected on antetal ultrasound and followed up completely with photographs. The.... ...

Aldo-keto reductases (AKRs) are a class of NADPH-dependent oxidoreductases that have been linked to metabolism of the anthracyclines doxorubicin (DOX) and daunorubicin (DAUN). Although widely used, cardiotoxicity continues to be a serious side effect that may be linked to metabolites or reactive intermediates generated in their metabolism. In this study we examine the little known effects of nonsynonymous single nucleotide polymorphisms of human AKR1A1 on the metabolism of these drugs to their alcohol metabolites. Expressed and purified from bacteria using affinity chromatography, the AKR1A1 protein with a single histidine (6x-His) tag exhibited the greatest activity using two test substrates: p-nitrobenzaldehyde (5.09 ± 0.16 μmol/min/mg of purified protein) and dl-glyceraldehyde (1.24 ± 0.17 μmol/min/mg). These activities are in agreement with published literature values of nontagged human AKR1A1. The 6x-His-tagged AKR1A1 wild type and allelic variants, E55D and N52S, were subsequently ...

With these new results it becomes even more obvious why HFCS which is actually a mixture of glucose and fructose is particularly nasty. It will not only increase the absorption of fructose (see Figure 2), but also provide our bodies with the necessary substrate to top an already overabundant fructose intake off with endogenously fructose to create something even I, as an outspoken critic of the fructose hypothesis of obesity would say is part of the perfect obesogenic storm and could easily explain why soft drink intake is so closely associated with an increased risk for obesity, fatty liver and insulin resistance ...

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Parkinson s disease (PD) is a neurodegenerative disorder with a wide range of motor and non-motor symptoms. Despite optimal medical management, PD still results in a high disability rate and secondary complications and many patients lead a sedentary lifestyle, which in turn is also associated with a higher co-morbidity and mortality. Exercise has been explored as a strategy to reduce secondary complications and results suggests that it not only provides general health benefits, but may also provide symptomatic relief. If this holds true exercise would be a very attractive addition to the therapeutic arsenal in PD. The supportive evidence remains incomplete. Here, we describe the design of the Park-in-Shape study, which primarily aims to evaluate whether aerobic exercise affords clinically relevant improvements in motor symptoms in sedentary PD patients. A specific new element is the introduction of gaming to optimize compliance to the exercise intervention ...

The National Institute of Standards and Technology (NIST) uses its best efforts to deliver a high quality copy of the Database and to verify that the data contained therein have been selected on the basis of sound scientific judgment. However, NIST makes no warranties to that effect, and NIST shall not be liable for any damage that may result from errors or omissions in the Database ...

Recombinant fragment corresponding to amino acids 224-323 of Human AKR1C2, with N terminal proprietary tag; predicted MW: 36.63 kDa inclusive of tag. AAH63574.

Gene target information for Dnajb11 - DnaJ heat shock protein family (Hsp40) member B11 (house mouse). Find diseases associated with this biological target and compounds tested against it in bioassay experiments.

CD205LY-75, CLEC13BLy-75, C-type lectin domain family 13 member B, DEC-205CD205 antigen, gp200-MR6, GP200-MR6, lymphocyte antigen ...

FAM107B - FAM107B (Myc-DDK-tagged)-Human family with sequence similarity 107, member B (FAM107B) available for purchase from OriGene - Your Gene Company.

Yapon gəmiləri Rabaula istiqamətlənir. Təxmini olaraq saat 1:40 radəlırindən «Onami» və «Makinami» amerikanlar tərəfindən aşkarlanır. «Çarlz Ocborn», «Klakstoun» və «Dayson» amerikan gəmiləri yapon gəmilərini görən kimi onlara torpedo zərbələri endirilir. İlk torpedo zərbəsi ilə Onami gəmisi suya qərq olur. «Makinami» gəmisi isə ağır zərbə almışdır. «Konversa» və «Spensa» gəmiləri artileriya zərbələri ilə batırılır. Yaponlar digər gəmiləri qorumaq məqsədi ilə ayrılırlar. Gəmilərin hərəsi bir istiqamətə yönəlir. Amerikanlar «Yoqiri» gəmisini təqib edirlər. Ağır artileriya zərbələri nəticəsində saat 3:28 radələrində gəmi batırılır[4]. Amerikanların digər gəmiləri təqib etmək cədhi uğursuzluqla nəticələnir. Döyüşdə iştirak etmiş gəmilər 4:04 radələrində geri qayıdırlar. ...

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Principal Investigator：三浦 金次, Project Period (FY)：1990, Research Category：Grant-in-Aid for Encouragement of Young Scientists (A), Research Field：General surgery

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Life expectancy is shortened only slightly in persons with MS, and the survival rate is linked to disability. Death usually results from secondary complications (50-66%), such as pulmonary or renal ca... more

Help! My child stuck ___ up his nose! If youve ever said these words, you know how awful it can be to know your little one has something stuck up there but cannot blow it out. The longer it has been there, the more chance there will be secondary complications, such as irritation to the […]. ...

Learn about Esophageal choke which usually occurs when a horse bolts down incompletely chewed feed or foreign objects, what can be done to treat the choking horse, and why it is important to resolve the problem quickly to prevent secondary complications.

Research Summary: China started sorbitol production from late 1950s,stimulated by the production of vitamin C. China is growing strong in the production of sorbitol. The quality of Chinese solid sorbitol, crystalline sorbitol in particular, has been improved. It seems that, with the improvement of Chinese sorbital quality, the import of sorbitol will decrease and the export will […].... ...

Stepan Companys expandsion of its polyester polyol facility in Brzeg Dolny, Poland will be completed in mid 2016, with the addition of a new reactor. The new asset is required to support Stepans growth in the Coatings Adhesives

This practice of crying to the gurus from afar is well known to everyone. The key to invoking blessings is devotion, which is aroused by sadness and renunciation. It should not be a mere platitude but be born in the center of ones bones. With decisive conviction that there is no other buddha who is greater than the guru, recite this melodic tune ...

Yarış ve gezi yelkeni işine önem veren önde gelen yelken üreticileri, 4T FORTE™ kompozit teknolojisi ve diğer özel içerikli materyaller ile one sails kullanmaktadırlar.

Yarış ve gezi yelkeni işine önem veren önde gelen yelken üreticileri, 4T FORTE™ kompozit teknolojisi ve diğer özel içerikli materyaller ile one sails kullanmaktadırlar.

... İsrailin Filistinde yürüttüğü katliama savaş denemez. Çünkü, İsrailin bütün imkanları karşısında Filistin, yok denecek kadar basit silahlara sahiptir. Uçağı yok, donanması yok, tankı yok, hava savunması yok. İsrail bu saldırılar boyunca, çaresiz kalan İslâm Aleminin onurunu ve izzetini de ayaklar altına almıştır. Maalesef, Milleti Müslüman olan hiçbir ülke, İsrail karşısına, anladığı dil olan, silahlı kuvveti ile dikilememiştir. Filistin Halkı, son saldırılarda, "İslâmın Gazzedeki Ordusu" olduğunu ispat etmiştir. Milleti Müslüman olan Devletler, ya Filistini kendi silahlı kuvvetleri ile korumalıdırlar, ya da Filistin için İsrail ile baş edebilecek modern bir silahlı kuvvet oluşturmalıdır. Bu mümkündür. Önce hayal edilir, sonra fikir ortaya çıkar, arkasından proje ve planlama gelir, icraat faaliyetin son safhadır. Biz henüz hayal etme safhasındayız. 2009 yılında (E) Tuğg Adnan Tanrıverdi, "

Tüm ürünlerimiz Türkiyede araştırılıp, tasarlanıp ve üretilmektedir. İş ortamımız yaratcılığı teşvik etmekle kalmayıp, yüksek kaliteli ürün ve servisleri sağlamayı amaçlamaktadır. Tüm çalışanlarımız ürünlerimizin ve üretim süreçlerimizin sürekli optimizasyonunda aktif rol oynamaktadırlar.. ...

Kocaeli Güven Nakliyat Türkiye geneli profesyonel, kaliteli, güvenilir bir taşımacılık hizmeti veren kurumsal bir firmadır. Kurumsal olan firmalarda personellerin her birinin uzmanlık alanları vardır ve bu alanda en iyi şekilde çalışma yapmaktadırlar. Her işi aynı anda yapan çalışandan ziyade kendi işini yapan çalışanlar sayesinde iyi bir iş ortaya çıkar ve sorunsuz taşımacılık hizmeti gerçekleşmiş olur. Bütün bunların dışında kullanılan ekipmanda son teknoloji, bulunabilecek en iyi malzemeler ve en işlevsel olanlarından seçilmektedir. Bu sayede eşyalarınız son derece korunaklı şekilde transfer edilmekte, sağlıklı bir taşıma yapılmaktadır ...

Stable personal care composition comprising hydrophobic modified silica, a particulate material and a dermatologically-acceptable carrier, said carrier comprising about 70% or greater, by weight of the carrier, of at least one water-soluble polyol, said water-soluble polyol having a solubility parameter of from about 11 to about 17.

Sorbitol market size was estimated at 1.85 million tons in 2015 and is likely to surpass 2.4 million tons by 2023 growing at a CAGR of over 3.5% from 2016 to 2023.