Aoki, Y.-h., Ohkoshi, S., Yamagiwa, S., Yano, M., Takahashi, H., Waguri, N., Igarashi, K., Sugitani, S.-i., Takahashi, T., Ishikawa, T., Kamimura, T., Wakabayashi, H., Watanabe, T., Matsuda, Y., Nomoto, M. and Aoyagi, Y. (2011), Characterization of elevated alanine aminotransferase levels during pegylated-interferon α-2b plus ribavirin treatment for chronic hepatitis C. Hepatology Research, 41: 118-125. doi: 10.1111/j.1872-034X.2010.00749.x ...
Background: About 25% of patients with chronic hepatitis C virus (HCV) infection have persistently normal alanine aminotransferase (ALT) values (1). No agreement about management of these patients exists (2). The standard of care for chronic HCV infection is the combination of peginterferon plus ribavirin, and the addition of amantadine may increase the virologic response (3, 4). However, optimal treatment in patients with persistently normal ALT levels has not been investigated ...
Our findings demonstrate that elevated ALT levels are independently associated with increased CVD- or diabetes-related mortality in Koreans. Thus, elevated ALT levels, as a marker for NAFLD, may serve as a surrogate predictor of CVD- or diabetes-related mortality among the Korean population.
TY - JOUR. T1 - Updated thresholds for serum alanine aminotransferase level in a large-scale population study composed of 34 346 subjects. AU - Wu, W. C.. AU - Wu, C. Y.. AU - Wang, Y. J.. AU - Hung, H. H.. AU - Yang, H. I.. AU - Kao, W. Y.. AU - Su, C. W.. AU - Wu, J. C.. AU - Chan, W. L.. AU - Lin, H. C.. AU - Lee, F. Y.. AU - Lee, S. D.. PY - 2012/9/1. Y1 - 2012/9/1. N2 - Background: The sensitivity of current upper limit of normal (ULN) of serum alanine aminotransferase (ALT) levels for detecting chronic liver disease has been challenged recently. Aim: To identify modulating factors for serum ALT levels and to refine its ULN threshold. Methods: We enrolled 34 346 consecutive subjects who completed the health check-up at Taipei Veterans General Hospital from 2002 to 2009. ULN was set for healthy ALT level to the 95th percentile of the reference healthy population. Results: A group of 21 282 subjects were used as a training set to define an ULN with the highest sensitivity; afterwards, this ...
Phenobarbital (PB) therapy is frequently associated with elevated serum alanine aminotransferase (ALT) and alkaline phosphatase (AP) activities in dogs without clinical signs of liver disease. The goal of this study was to determine if increased serum ALT and AP activities in clinically healthy PB-treated epileptic dogs are due to hepatic enzyme induction or to subclinical liver injury. Liver biopsies were obtained from 12 PB-treated dogs without clinical signs of liver disease but with elevated Show morePhenobarbital (PB) therapy is frequently associated with elevated serum alanine aminotransferase (ALT) and alkaline phosphatase (AP) activities in dogs without clinical signs of liver disease. The goal of this study was to determine if increased serum ALT and AP activities in clinically healthy PB-treated epileptic dogs are due to hepatic enzyme induction or to subclinical liver injury. Liver biopsies were obtained from 12 PB-treated dogs without clinical signs of liver disease but with elevated ...
Results: Risk factors for ALT elevation differed by gender. Predictor variables that were significantly associated with ALT elevation in both sexes included; elevated baseline ALT level [β=10.14 (95%CI 7.34- 12.96); P,0.001], [β=13.52 (95%CI 9.36 -17.68); P , 0.001] and renal disease [β=5.44 (95%CI 2.62 - 8.25); P ,0.001], [β=11.52 (95%CI 3.46 - 19.60); P = 0.005] in females and males respectively. Ethnicity had a protective effect in both sexes; [β-6.61(95%CI- 9.28, -3.93); P, 0.001] in males and [β-1.20 (95% CI-2.39, -0.01); P= 0.048] in females. Among the different ethnic groups, Nilotes and Cushites had lower ALT levels compared to Bantus. Other factors that were significant included; smoking (P=0.001), concurrent illnesses (P=0.045), previous adverse drug reactions (P=0.040) in females and a longer duration of anti-retroviral therapy [β 1.81(95%CI 0.89 - 2.73); P , 0.001] in males. Poor adherence had a protective effect [β -1.62(95%CI -3.20, -0.04); P=0.045] among females, whereas ...
Previous animal studies have shown that Curcuma longa (turmeric) improves liver function. Turmeric may thus be a promising ingredient in functional foods aimed at improving liver function. The purpose of the study is to investigate the hepatoprotective effect of fermented turmeric powder (FTP) on liver function in subjects with elevated alanine transaminase (ALT) levels. A randomised, double-blind, placebo-controlled trial was conducted between November 2010 and April 2012 at the clinical trial center for functional foods of the Chonbuk National University Hospital. The trial included 60 subjects, 20 years old and above, who were diagnosed mild to moderate elevated ALT levels between 40 IU/L and 200 IU/L. Sixty subjects were randomised to receive FTP 3.0 g per day or placebo 3.0 g per day for 12 weeks. The treatment group received two capsules of FTP three times a day after meals, for 12 weeks. The primary efficacy endpoint was change in the ALT levels in the two groups. The secondary efficacy endpoints
The clinical pharmacokinetics of etoposide were studied in eight pediatric patients with refractory solid tumors. The α-phase half-life, β-phase half-life, volume of distribution, and elimination rate constant averaged 0.82 hr, 6.5 hr, 4.0 liters/sq m, and 0.25 hr-1, respectively. Noncompartmental parameters such as systemic clearance, mean residence time, and volume of distribution at steady-state averaged 20.9 ml/min/sq m, 7.8 hr, and 7.2 liters/sq m, respectively. A significant relationship between serum glutamic pyruvic transaminase and systemic clearance was observed, with patients having elevated serum glutamic pyruvic transaminase showing slower systemic clearance of etoposide. Systemic clearance, mean residence time, and β-phase half-life of etoposide were significantly lower in those patients who had received cisplatin prior to their Phase II etoposide trial. The average pharmacokinetic values derived from these eight pediatric patients with solid tumors did not differ significantly ...
Hepatitis Research and Treatment is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies related to all aspects of hepatitis.
Some chronic hepatitis C (CHC) patients exhibit persistently normal alanine aminotransferase (ALT) levels (PNAL). Patients with PNAL experience significantly milder disease. In order to understand the differences between CHC patients with elevated ALT levels compared with those with PNAL better, we compared epidemiological, immunological and histological findings, in particular, the value of proliferating hepatocyte activity (PCNA) between the two groups of patients. We studied 40 chronic hepatitis C virus (HCV) carriers with increased ALT who underwent liver biopsy for histological diagnosis and determination of clinical prognosis, and 24 PNAL patients under follow-up for 10 years. Immunological response to different HCV genomic epitopes was tested in both the control group and in PNAL subjects. PCNA values from liver specimens of all patients as well as liver biopsies of PNAL patients at time points 0 and 5 years were calculated according to Hall et al.Age, sex and body mass index (BMI) were ...
To the editor: Previous studies (1, 2) have established a direct relation between elevated alanine aminotransferase (ALT) levels in donor blood and the risk for post-transfusion hepatitis. In an independent study (3), we determined the extent to which continuing transaminase elevation is a manifestation of chronic persistent hepatitis (non-A, non-B chronic persistent hepatitis) or of insignificant steatosis.. Of 103 patients with persistent or intermittent asymptomatic transaminase elevation, no patient had acute or chronic infectious hepatitis, autoimmune hepatitis, primary biliary cirrhosis, or thesaurismosis, or was receiving hepatotoxic drugs. Seronegative chronic hepatitis (group 1) was differentiated from steatosis (group 2) by biopsy means. The histologic findings in group 1 were mild portal infiltration rich in lymphocytes and plasma cells, and lymph follicles with germinal centers and bile duct lesions.. Group 1 comprised 46 patients with different modes of infection (posttransfusion h ...
Introduction: Cardiovascular diseases (CVD) are major causes of mortality among U.S. Hispanic/Latino farmworkers. Since Hispanics/Latinos, in general, are twice as likely as non-Hispanic whites to have elevated alanine aminotransferase (ALT), a biomarker of suspected nonalcoholic fatty liver disease, it is vital to understand the CVD risk factor-ALT relationship in Hispanic/Latino farmworkers. This study investigated the elevated ALT status in Hispanic/Latino farmworkers and the relationships between ALT and CVD risk markers.Methods: In 210 Hispanic/Latino farmworkers (48% female; aged 35.2 ± 9.2 years), fasting blood samples were measured for serum ALT, and elevated ALT was defined by | 43 U/L. CVD risk markers were measured with standard methods and defined according to the definitions of metabolic syndrome.Results: The overall prevalence for elevated ALT was 12.4%. Significant linear upward trends across tertiles of serum ALT were observed for body mass index, waist circumference, fasting glucose
Case Reports in Hepatology is a peer-reviewed, Open Access journal that publishes case reports and case series related to the management of disorders affecting the liver, gallbladder, biliary tree, and pancreas.
Between December 1990 and August 1998, 19 patients with acute hepatitis B were admitted to our institution. A diagnosis of acute hepatitis B was based on elevated serum alanine aminotransferase activity, detection of HBsAg and immunoglobulin M antibody to hepatitis B core antigen (anti-HBc) in the serum, and the recent onset of jaundice and other typical symptoms. Coinfection with hepatitis A, C, D, or E; Epstein-Barr virus; or cytomegalovirus was ruled out because of the negative results of serologic tests. Confounding etiology of liver disease, human immunodeficiency virus infection, and other immunodeficient diseases were not found in any patient. In 2000, this complete series of patients with acute hepatitis B was contacted for follow-up. Fourteen patients (74%) revisited our institution and were reevaluated for clinical, serologic, histologic, and virologic recovery from the disease. The group comprised 11 men and 3 women ranging in age from 26 to 65 years (median, 43 years). All patients ...
Diabetes is a less-recognized association of hepatitis-C virus (HCV) infection, although several recent studies provide data linking HCV infection and diabetes (1-5). To investigate whether patients with chronic HCV infection without evidence of cirrhosis have an increased risk of diabetes, we conducted a case-control study in 44 consecutive eligible patients with HCV infection and no clinical or histological evidence of cirrhosis and in 20 control subjects without liver disease who were matched by age, sex, and BMI. All 44 patients with chronic HCV infection had biochemical evidence of ongoing inflamation with elevated alanine aminotransferase activity and histologic confirmation. There was no evidence of decompensated liver disease. No patient received any antiviral, immunomodulatory, or immunosuppressive therapy. Immunoreactive insulin was determined by double-antibody radiomimmunosassay (Coat-a-count; Diagnostic Products, Los Angeles, CA). Serum leptin level was determined by the ...
Management of Chronic Viral Hepatitis is an A5 sized multiauthor textbook of over 300 pages which forms one of eight books in a gastroenterology and hepatology series. Curiously, the only other hepatological title in this series is a book entitled Viral Hepatitis: Diagnosis, Treatment, Prevention by a different editor. The stated intention of the book is to bring the recent advances in clinical and basic research into the doctors office. Through the use of clinical vignettes, it tries to cover some of the recent advances in the treatment of viral hepatitis and to demonstrate how these treatments are incorporated into everyday practice. This is a good idea, which works well, particularly in those chapters concerning treatment. In addition to looking at the general treatment of viral hepatitis, the book also has informative chapters on specific disease subsets such as those with chronic hepatitis C and normal alanine aminotransferase levels or those with human immunodeficiency virus (HIV) and ...
The changes in the gut microbiota of healthy hepatitis B virus (HBV) carriers, including asymptomatic and non-cirrhotic subjects, have been rarely scrutinized. From 1463 faecal samples in health examinees, in total 112 subjects, including 36 hepatitis B surface antigen (HBsAg)-positive and 76 control subjects, were included. Twenty-eight of 36 HBsAg-positive individuals (78%) showed normal alanine aminotransferase (ALT) levels (normal ALT group), whereas eight subjects exhibited elevated ALT levels (22%, high ALT group). By using 16S rRNA gene sequencing, the distance between normal and high ALT groups among HBsAg-positive subjects showed a significant separation after the pairwise comparison of weighted UniFrac distance (permutational analysis of variance q-value = 0.039), when compared with the distances to the control group. In comparison with the control group, the normal ALT group had Anaerostipes as a significant taxon that showed a positive association (Coefficient (Coef.) = 0.028, q = 0.039).
To the Editor: Chronic hepatitis C virus (HCV) infection affects almost 200 000 Australians.1 It is monitored clinically by serial liver function tests (LFTs) and HCV RNA detection by polymerase chain reaction (PCR). HCV RNA is a marker of chronic infection and levels reflect response to antiviral therapy. However, testing for the presence of HCV RNA is expensive and, under the current Medicare Benefits Schedule, is not available to people with HCV antibodies and abnormal LFTs unless they are undergoing antiviral therapy.. ...
Percentage of overall number of adverse events experienced during Weeks 0-144 by adverse event type. Doctors asked participants for adverse events, grouped them into categories given in the electronic case report form (eCRF). The list of adverse events included in the eCRF were hypertriglyceridemia, hypercholesterolemia, low high density lipoprotein (HDL) cholesterol, high low density lipoprotein (LDL) cholesterol, hyperglycemia, hyperbilirubinemia, elevated aspartate aminotransferase (AST), elevated alanine aminotransferase (ALT), elevated gamma glutamyl transferase (γGT), elevated alkaline phosphatase, stomatitis, nausea, vomiting, diarrhea, abdominal pain, mood disorder, neurocerebellar disorder, neurocontrol disorder, headache, fatigue, fever, other (listed as 'not specified&apos ...
Percentage of overall number of adverse events experienced during Weeks 0-144 by adverse event type. Doctors asked participants for adverse events, grouped them into categories given in the electronic case report form (eCRF). The list of adverse events included in the eCRF were hypertriglyceridemia, hypercholesterolemia, low high density lipoprotein (HDL) cholesterol, high low density lipoprotein (LDL) cholesterol, hyperglycemia, hyperbilirubinemia, elevated aspartate aminotransferase (AST), elevated alanine aminotransferase (ALT), elevated gamma glutamyl transferase (γGT), elevated alkaline phosphatase, stomatitis, nausea, vomiting, diarrhea, abdominal pain, mood disorder, neurocerebellar disorder, neurocontrol disorder, headache, fatigue, fever, other (listed as not specified ...
Results: We included 8 articles comprising 7,467 COVID-19 patients. When compared between severe and non-severe COVID-19 patients, the pooled ORs of elevated alanine aminotransferase, aspartate aminotransferase, total bilirubin, and lactate dehydrogenase levels were 2.35 (95% CI 1.38-3.98), 3.21 (95% CI 2.59-3.98), 1.87 (95% CI 1.32-2.65), and 4.83 (95% CI 2.90-8.05), respectively. ...
This page includes the following topics and synonyms: Alanine Aminotransferase, Serum Glutamic Pyruvic Transaminase, Glutamic Pyruvate Transaminase, Serum ALT, ALT, SGPT, Aminotransferase.
Diagnosis and monitoring of liver disease associated with hepatic necrosisAlanine transaminase (ALT) is also called alanine aminotransferase (ALAT) and was formerly called serum glutamate-pyruvate transaminase (SGPT) or serum glutamic-pyruvic transaminase (SGPT). ALT is found in plasma and in various body tissues, but is most common in the liver. This test is commonly measured clinically as biomarkers for liver health. The tests is a are part of Liver function test (LFT). ...
TY - JOUR. T1 - Serodiagnostic Assay of Hepatitis C Virus Infection Using Viral Proteins Expressed in Escherichia coli. AU - Mori, Shigehisa. AU - Ohkoshi, Showgo. AU - Hijikata, Makoto. AU - Kato, Nobuyuki. AU - Shimotohno, Kunitada. PY - 1992/3. Y1 - 1992/3. N2 - Infection with hepatitis C virus (HCV) was analyzed by an enzyme‐linked immunosorbent assay based on recombinant viral proteins encoded by regions of the putative viral core, NS3, NS4 and NS5, which were expressed in E.coli Results showed that 106 of 124 cases (85.5%) of non‐A, non‐B chronic hepatitis and 43 of 45 cases (95.5%) of hepatocellular carcinoma, negative for HBV marker, were positive for antibodies against at least one of these viral proteins. One of 87 healthy individuals with normal alanine aminotransferase activity was positive for antibody against only the viral core, but was negative for HCV RNA. The serum of one patient with chronic hepatitis was positive for one of these proteins, but negative for HCV RNA. ...
Reference: Ilin V.S., Kovner F.Ia., Hexokinase, aspartate and alanine aminotransferase activity in transplanted rat sarcomas, Voprosy meditsinskoi khimii, 1971, vol: 17(6), 644-649 ...
Miriam Vos, MD, from Emory University and Childrens Healthcare in Atlanta, Georgia, and colleagues reviewed data on 10,359 adolescents 12 to 18 years of age from the National Health and Examination Survey, spanning 1988 to 2008. Suspected NAFLD was defined as a body mass index at least in the 85th percentile and elevated alanine aminotransferase (ALT; above 25.8 U/L for boys and above 22.1 U/L for girls). To allow for comparisons with earlier studies, they also analyzed the data based on ALT levels above 30.0 U/L ...
SGPT/Serum Glutamic Pyruvic Transaminase (Alanine Transaminase /ALT) adalah enzim yang ditemukan terutama di sel-sel hati dan ginjal, dan dalam jumlah yang lebih kecil ditemukan di jantung dan otot ...
Lutful Haque Saran, Mohsina Mukti, Md. Reyad-Ul-Ferdous*, A. H. M. Mahmudur Rahman, Md. Mamun- Ur- Rashid, Naim Islam, Adnan Taher. ABSTRACT. Objective: In recent era diabetics becomes most pathological condition worldwide. Maximum populations in both develop and developing countries suffering from diabetic. There are several diseases associated with diabetics like as kidney, liver, heart diseases etc. Methods: In this study, retrospectively study conducted at BUSB. Then data were entered into computer and results were calculated with the help of Microsoft Excel. Results: In the study, it has been found that the percentage of female is found to be 53% with diabetes and the percentage of male is found to be 46%.The level of Serum glutamic pyruvic transaminase (SGPT) also called (Alanin Transaminase) is found to be relatively high amongst the diabetes patient who reflects that the liver problems are prominent amongst diabetes patients. The average value of alanine transaminase which is released ...
SGPT, or serum glutamic pyruvic transaminase, is an enzyme that enters the blood when the heart or liver are damaged, according to MedicineNet. When a condition like hepatitis C causes damage to the...
The investigators reported that of 5780 eligible persons aged 18 to 75 years, 3345 agreed to participate in the study.. The team defined subjects with suspected liver disease on the basis of elevated serum alanine aminotransferase and -glutamyl-transferase activity.. Suspected liver disease was also defined on the basis of hepatitis B surface antigen, or hepatitis C virus-RNA positivity.. The subjects were matched with randomly selected subjects of the same age and sex without suspected liver disease.. The investigators reported that 311 subjects with and 287 without suspected liver disease underwent clinical, laboratory, and anthropometrical evaluation.. Fatty liver was diagnosed by ultrasonography, and alcohol intake was assessed by using a 7-day diary.. The investigative team used multinomial logistic regression to detect risk factors for normal liver versus nonalcoholic fatty liver disease and vice versa.. The investigators found that the prevalence of nonalcoholic fatty liver disease was ...
Definition : Clinical chemistry reagents intended to perform qualitative and/or quantitative chemical analyses of body fluids (typically serum) to determine the level of the enzyme alanine transferase (ALT), also known as alanine aminotransferase. ALT in serum is typically increased in liver diseases associated with hepatic necrosis, such as viral hepatitis and infectious mononucleosis with involvement of the liver.. Entry Terms : "Glutamic-Pyruvic Transaminase (GPT) Reagents" , "ALT (Alanine Transferase) Determination Reagents" , "Alanine Transferase (ALT) Determination Reagents" , "Alanine Transaminase Reagents" , "Alanine Amino-Transferase Determination Reagents" , "Alanine Aminotransferase Determination Reagents" , "Reagents, Clinical Chemistry, Enzyme, Alanine Transferase". UMDC code : 18872 ...
Acute and chronic liver injuries increase serum concentrations of aspartate aminotransferase (AST) and alanine aminotransferase (ALT). Abnormal AST and ALT liver enzymes may signal liver damage. ALT elevation is more specific for liver damage because AST is present in the heart, skeletal muscle, kidneys, brain, and red blood cells. AST and ALT elevations greater than 10 times the normal limit are associated with acute hepatic injury (eg, toxic liver injury or acute viral hepatitis). Cirrhosis and chronic hepatitis also increase AST and ALT, but not to the same degree as acute injury. AST and ALT levels may be within the normal range in patients with cirrhosis or chronic liver disease. Elevations in alkaline phosphatase (alk phos) and γ-Glutamyl transpeptidase (GGT) may accompany cholestatic liver disease (eg, drug-induced cholestasis, cholangitis). Alk phos and GGT are present in other tissues; therefore, they lack specificity for liver disease. Though also nonspecific for liver disease, ...
Primate model of sepsis. (a) Lethal E. coli infusion alone. (b) Lethal E.coli plus Activated Protein C infusion. SGPT, serum glutamic pyruvic transaminase (indi
alaA; glutamate-pyruvate aminotransferase; glutamic-pyruvic transaminase (GPT); alanine transaminase; K14260 alanine-synthesizing transaminase [EC:2.6.1.66 2.6.1.2] ...
alaA; glutamate-pyruvate aminotransferase; glutamic-pyruvic transaminase (GPT); alanine transaminase; K14260 alanine-synthesizing transaminase [EC:2.6.1.66 2.6.1.2] ...
Everything you need to know about Alanine Aminotransferase (ALT) and find out which of our blood tests check Alanine Aminotransferase levels.
Alanine aminotransferase (ALT or GPT) test Liver Function Panel Colorimetric Technique General Concept 1) Names:- Formal name: Alanine Aminotransferase and abbreviated as (ALT) Also known as: Serum Glutamic-Pyruvic Transaminase; SGPT; GPT; Alanine Transaminase. 2) What is the ALT? Read about it... Continue reading → ...
Purpose: It has been shown that liver fibrosis, and even cirrhosis, may be reversible in humans. For this reason there is a great need for the imminent introduction of non-invasive and clinically useful methods in order to monitor fibrosis in patients [1, 2]. A body of evidence points to the fact that MRE is a highly useful candidate towards this end [3]. However, before using such techniques more widely, it is important to verify that comparable physical measures are provided by alternative and clinically relevant MRE approaches. The aim of this pilot study was to compare 2D and 3D MRE, also known as MR Rheology, using a commercially available 2D system, with an acoustic transducer, and 3D MRE research system, with an electromagnetic transducer, with respect to liver stiffness and elasticity in patients with diffuse or suspected diffuse liver disease. Materials and Methods: Seven patients, referred to our hospital for evaluation of elevated serum alanine aminotransferase (ALT) and/or alkaline ...
abbr. (in clinical biochemistry): ALT; EC 2.6.1.2; systematic name: l‐alanine:2‐oxoglutarate aminotransferase; other names: glutamic‐pyruvic transaminase; glutamic‐alanine transaminase. An enzyme that catalyses the reversible reaction:. l‐alanine + 2‐oxoglutarate = pyruvate + l‐glutamate.. [...] ...
Endotoxin-mediated proinflammatory cytokines play a significant role in the pathogenesis of acute and chronic liver diseases. Heat shock protein 90 (molecular weight, 90 kDa) (hsp90) functions as an important chaperone of lipopolysaccharide (LPS) signaling and is required for the production of proinflammatory cytokines. We hypothesized that inhibition of hsp90 would prevent LPS-induced liver injury by decreasing proinflammatory cytokines. C57BL/6 mice were injected intraperitoneally with an hsp90 inhibitor, 17-dimethylamino-ethylamino-17-demethoxygeldanamycin (17-DMAG), and LPS. Parameters of liver injury, proinflammatory cytokines, and associated mechanisms were studied by in vivo and in vitro experiments. Inhibition of hsp90 by 17-DMAG prevented LPS-induced increases in serum alanine aminotransferase activity and significantly reduced serum tumor necrosis factor alpha (TNFalpha) and interleukin-6 (IL-6) protein as well as messenger RNA (mRNA) in liver. Enhanced DNA-binding activity of heat shock
Pazopanib is a multitargeted tyrosine kinase inhibitor that is approved for the treatment of advanced renal cell carcinoma and soft tissue sarcomas. However, treatment of patients with advanced disease can be challenging due to impaired liver function from metastasis. Pazopanibs package insert has a black box warning due to severe and fatal hepatotoxicity observed in clinical trials and currently there is limited information regarding pazopanib in patients with liver dysfunction. In a phase I study of pazopanib in patients with advanced hepatocellular carcinoma, the maximum-tolerated dose was determined to be 600 mg per day. Evidence of antitumor activity was seen at this dose; however, the 800 mg per day dose was not tolerable due to dose-limiting toxicities of grade 3 malaise and grade 3 AST/ALT elevation. Liver abnormalities were seen in a majority of the patients with hepatocellular carcinoma treated with pazopanib. AST elevation was seen in 63% of the patients. ALT elevation occurred in ...
Alanine aminotransferase measurements are used in the diagnosis and treatment of certain liver diseases (e.g. viral hepatitis and cirrhosis) and heart diseases. In viral hepatitis and other forms of liver disease associated with hepatic necrosis, serum ALT levels are elevated even before clinical signs and symptoms of the disease ...
Alanine Transaminase antibody LS-C100675 is an unconjugated rabbit polyclonal antibody to human Alanine Transaminase (GPT ). Validated for Flow, IHC and WB.
Alanine Transaminase antibody LS-C292687 is an unconjugated rabbit polyclonal antibody to rat Alanine Transaminase (GPT ). Validated for WB.
The Mammalian Phenotype (MP) Ontology is a community effort to provide standard terms for annotating phenotypic data. You can use this browser to view terms, definitions, and term relationships in a hierarchical display. Links to summary annotated phenotype data at MGI are provided in Term Detail reports.
The Mammalian Phenotype (MP) Ontology is a community effort to provide standard terms for annotating phenotypic data. You can use this browser to view terms, definitions, and term relationships in a hierarchical display. Links to summary annotated phenotype data at MGI are provided in Term Detail reports.
Of the 275 participants, 88 (32%) had HIV infection, 76% were black, and 67% were men. The group averaged 58 years in age, and time from HCV diagnosis to SVR averaged 9.3 years. Time since SVR averaged 18 months. HAI fibrosis stages were 0-1 in 60%, 2-3 in 27%, and 4 in 13%. Thirty-two people (12%) had cirrhosis, and 69 (31%) had grade 1 or worse steatosis. More than half of participants, 58%, had a history of injecting drugs ...
ASPARATE TRANSFERASE. Aspartate transferase AST is besides known as SGOT ( serum glutamic oxolacetic ) , an enzyme that is frequently present in liver cells are damaged, this enzyme is chiefly caused by the cell in the liver. High degrees of this enzyme implicates the liver is harm, AST is released into the blood the sum of protein is relative to the sum of damaged cells. The tallness of AST relies on how long the blood is tested after the accident, the consequences of rectification of circulatory upsets frequently shows a really rapid lessening in degrees of AST.. SERUM ALANINE AMINOTRANSFERASE. Serum alanine transaminase is besides known as ALT, which measures the sum of the enzyme ALT in the blood. ALT is found in liver and musculus, ALT does non needfully bespeak the badness of liver harm. ALT tends to be somewhat higher than the degree of AST and this may be of import in the sensing of necroinflammatory activity in patients with chronic diseases hepatisis.. ALKALINE PHOSPHATE. Alkaline ...
The clinical and epidemiological relevance of circulating antibodies to hepatitis C virus (HCV) in hemodialysis patients is uncertain, since clinical signs of infection are often mild or absent, with alanine aminotransferase (ALT) values that are virtually always normal, and liver biopsies are only rarely performed. Determination of HCV RNA in serum is therefore critical for distinguishing chronic HCV infection from previous exposure to the virus. We studied HCV viremia by reverse transcription polymerase chain reaction (RT- PCR) in the 5-noncoding region of the viral genome in 77 dialysis patients who were screened for anti-HCV by a second-generation enzyme-linked immunosorbent assay (the enzyme immunoassay II; Ortho HCV, 2nd generation, Ortho Diagnostic Systems Raritan, N.J.) and a second-generation recombinant immunoblot assay (Chiron Corporation and Ortho Diagnostic Systems) and prospectively evaluated for ALT elevations over a period of 5 years. of 77 patients tested, 29 (38%) had active ...
SGPT blood test is a test used to measure the amount of the enzyme glutamate pyruvate transaminase in blood serum. Know significance, benefits & features.