Fingerprint Dive into the research topics of Effects of aerobic fitness on aging-related changes of interhemispheric inhibition and motor performance. Together they form a unique fingerprint. ...
TY - JOUR. T1 - Calorie restriction initiated at middle age improved glucose tolerance without affecting age-related impairments of insulin signaling in rat skeletal muscle. AU - Park, Seongjoon. AU - Komatsu, Toshimitsu. AU - Hayashi, Hiroko. AU - Yamaza, Haruyoshi. AU - Chiba, Takuya. AU - Higami, Yoshikazu. AU - Kuramoto, Kazunao. AU - Shimokawa, Isao. PY - 2006/9. Y1 - 2006/9. N2 - Calorie restriction (CR) may affect glucose tolerance via modulation of the insulin action in skeletal muscle. The present study investigated the effect of CR initiated at middle age in rats bearing glucose intolerance, in comparison with CR at a younger age. Male F344 rats at 2.5 and 18 months (mo) of age were fed ad libitum (AL) or 30% CR diets for 4-4.5 mo, subjected to glucose tolerance testing, and then sacrificed 15 min after intraperitoneal glucose or saline injection to evaluate glucose-stimulated insulin response and subsequent activation of insulin signaling molecules. The protein abundance of ...
Skeletal muscle undergoes a progressive age-related loss in mass and function. Preservation of muscle mass depends in part on satellite cells, the resident stem cells of skeletal muscle. Reduced satellite cell function may contribute to the age-associated decrease in muscle mass. Here, we focused on characterizing the effect of age on satellite cell migration. We report that aged satellite cells migrate at less than half the speed of young cells. In addition, aged cells show abnormal membrane extension and retraction characteristics required for amoeboid-based cell migration. Aged satellite cells displayed low levels of integrin expression. By deploying a mathematical model approach to investigate mechanism of migration, we have found that young satellite cells move in a random memoryless manner, whereas old cells demonstrate superdiffusive tendencies. Most importantly, we show that nitric oxide, a key regulator of cell migration, reversed the loss in migration speed and reinstated the ...
TY - JOUR. T1 - Effect of whole-body vibration training on body composition, exercise performance and biochemical responses in middle-aged mice. AU - Lin, Ching I.. AU - Huang, Wen Ching. AU - Chen, Wen Chyuan. AU - Kan, Nai Wen. AU - Wei, Li. AU - Chiu, Yen Shuo. AU - Huang, Chi Chang. PY - 2015/9/1. Y1 - 2015/9/1. N2 - Aims Whole-body vibration (WBV) is a well-known light-resistance exercise by automatic adaptations to rapid and repeated oscillations from a vibrating platform, which is also a simple and convenient exercise for older adults. However, the potential benefits of WBV on aging-associated changes in body composition, exercise performance, and fatigue are currently unclear. The objective of the study is to investigate the beneficial effects of WBV training on body composition, exercise performance, and physical fatigue-related and biochemical responses in middle-aged mice. Methods In total, 24 male C57BL/6 mice aged 15 months old were randomly divided into 3 groups (n = 8 per group): ...
Sphingolipids have been implicated in age-related neurodegeneration. Previous studies have reported elevated ceramide levels in the brain of old rodents, but a systematic investigation of the impact of age on brain sphingolipid metabolism is still lacking. Here we quantified 17 key sphingolipid species in the hippocampus of young (3months), middle-aged (12months) and old (21months) male and female mice. Lipids were extracted and quantified by liquid chromatography/mass spectrometry; transcription of enzymes involved in sphingolipid biosynthesis was evaluated by qPCR. Age-dependent changes of multiple sphingolipid species - including ceramide (d18:1/18:0), sphingomyelin (d34:1), hexosylceramide (d18:1/16:0), ceramide (d18:1/24:0) - were found in mice of both sexes. Moreover, sex-dependent changes were seen with hexosylceramide (d18:1/18:0), ceramide (d18:1/22:0), sphingomyelin (d36:1) and sphingomyelin (d42:1). Importantly, an age-dependent accumulation of sphingolipids containing nervonic acid ...
Background: A number of clinical trials using stem/progenitor cell transplantation in ischemic heart diseases are now on-going, however, aging-induced cell dysfunction may impair therapeutic efficacy. We tested the hypothesis that genetic modification of EPCs by sonic hedgehog (Shh), one of the embryonic morphogens, may ameliorate the loss of function in aged EPCs.. Methods and Results: Cultured EPCs were isolated from 3m.o. and 24m.o. mice and cell functions, including cytokine expression, were evaluated by real-time PCR. Proliferation, migration and adhesion activity were significantly decreased and apoptosis was increased in the 24m.o.-EPCs vs. 3m.o.-EPCs. The reduced expression of VEGF, eNOS, and IGF-1 were also observed in the 24m.o.-EPCs. We then evaluated the effect of Shh gene transfer to the 24m.o.-EPCs. Shh gene transfer significantly improved proliferation and anti-apoptosis activities in 24m.o.-EPCs vs. empty vector transfected (EV) 24m.o.-EPCs, up to a similar level of EV ...
Kubo KY, Kotachi M, Suzuki A, Iinuma M, Azuma K.. Chewing during prenatal stress prevents prenatal stress-induced suppression of neurogenesis, anxiety-like behavior and learning deficits in mouse offspring.. Int J Med Sci 15:849-58, 2018. Azuma K, Zhou Q, Kubo KY.. Morphological and molecular characterization of the senile osteoporosis in senescence-accelerated mouse prone 6 (SAMP6).. Med Mol Morphol 51:139-146, 2018. Azuma K, Toyama T, Katano M, Kajimoto K, Hayashi S, Suzuki A, Tsugane H, Iinuma M, Kubo KY.. Yokukansan ameliorates hippocampus-dependent learning impairment in senescence-accelerated mouse.. Biol Pharm Bull.41:1593-1599, 2018. Kizaki K, Uchida S, Yamashita F, Tsukamoto M, Azuma K.. Microstructure of osteophytes in medial knee osteoarthritis.. Clin Rheumatol. 37:2893-2896, 2018. Tsukamoto M, Wang KY, Tasaki T, Murata Y, Okada Y, Yamanaka Y, Nakamura E, Yamada S, Izumi H, Zhou Q, Azuma K, Sasaguri Y, Kohno K, Sakai A.. Findings as a starting point to unravel the underlying ...
1. Targonski P.V, Jacobson R.M, Poland G.A. Immunosenescence: role and measurement in influenza vaccine response among the elderly. Vaccine. 2007;25:3066-3069 2. Noreddin A.M, Haynes V. Use of pharmacodynamic principles to optimise dosage regimens for antibacterial agents in the elderly. Drugs Aging. 2007;24:275-292 3. Liang S.Y, Mackowiak P.A. Infections in the elderly. Clin Geriatr Med. 2007;23:441-456 4. Vasto S, Candore G, Balistreri C.R, Caruso M, Colonna-Romano G. et al. Inflammatory networks in ageing, age-related diseases and longevity. Mech Ageing Dev. 2007;128:83-91 5. High K.P, Prasad R, Marion C.R, Schurig G.G, Boyle S.M. et al. Outcome and immune responses after Brucella abortus infection in young adult and aged mice. Biogerontology. 2007;8:583-593 6. Htwe T.H, Mushtaq A, Robinson S.B, Rosher R.B, Khardori N. Infection in the elderly. Infect Dis Clin North Am. 2007;21:711-743 7. Hakim F.T, Gress R.E. Immunosenescence: deficits in adaptive immunity in the elderly. Tissue Antigens. ...
Food-grade diatomaceous earth possesses a number of anti-aging benefits. These anti-aging benefits include improvement in skin elasticity, softening of wrinkles and fine lines, and preventing the onset of age-related disorders, such as memory loss i.e. dementia and bone problems like osteoporosis. Lets take a look at how diatomaceous earth works to prevent the occurrence of osteoporosis in aged individuals. Role of Diatomaceous In Preventing Osteoporosis. Diatomaceous earth bloggers have said that it has a scientifically-proven role in maintaining the bone density and helping in overall bone formation. Its mostly beneficial in aged individuals who tend to go through age-related degeneration of bones. When a person ages, their total number of osteoclasts i.e. cells which are responsible for destruction of bone-cell tissues is much higher as compared to osteoblasts i.e. cells which are involved in integral bone formation because of their protein and minerals transport activity. This imbalance in ...
The molecular mechanisms by which heterogeneity, a major characteristic of stem cells, is achieved are yet unclear. We here study the expression of the membrane stem cell antigen-1 (Sca-1) in mouse bone marrow Mesenchymal Stem Cell (MSC) clones. We show that subpopulations with varying Sca-1 expression profiles regenerate the Sca-1 profile of the mother population within a few days. However, after extensive replication in vitro the expression profiles shift to lower values and the regeneration time increases. Study of the promoter of Ly6a unravels that the expression level of Sca-1 is related to the promoter occupancy by the activating histone mark H3K4me3. We demonstrate that these findings can be consistently explained by a computational model that considers positive feedback between promoter H3K4me3 modification and gene transcription. This feedback implicates bistable epigenetic states which the cells occupy with an age-dependent frequency due to persistent histone (de-)modification. Our ...
TY - JOUR. T1 - The role of estrogen in the development of age-related cognitive impairment and dementia. AU - Dumas, Julie. AU - Salerno, Jessica. AU - Newhouse, Paul. PY - 2006/4/1. Y1 - 2006/4/1. N2 - While evidence is conflicting, estrogen cannot be recommended for the treatment of dementia but may have a role in preserving cognitive functioning in older women. Estrogen may have a dementia-prevention effect after menopause based on epidemiologic studies (not primary prevention studies), but this is not an approved indication. At this point, the off-label prescribing of estrogen for cognitive decline in the absence of dementia is not a routine clinical practice and should be regarded as appropriate only within the context of a research study. Estrogen may be used in late-stage dementia to treat aggressive or sexually disinhibited behavior,45 but this would not be considered a routine use in dementia patients. Estrogen use after menopause has been linked to increased risk of venous thrombosis, ...
Introduction: Previous studies have shown significant age-related change in the first-order kernel response of the multifocal ERG (mfERG). However, they all involved use of ring averages across the retinal field. Purpose: To estimate the age-related changes in the localized response and retinal topography using point-to-point comparison. To determine the localized variability in the mfERG scalar product across age and the topography of the age-related change. Methods: MfERG recordings of 71 normal phakic subjects (ages 9-80) were analyzed with VERIS TM 4.8. The stimulus parameters were: 103 hexagons, 75 Hz frame rate, peak luminance 200 cd/m2, m= 2^14. Scalar products (for each hexagon based on ring average templates) were obtained and analyzed for age-related changes. Statistical measures (coefficient of variation (CV) and parameters of a linear regression model) were applied. Point-by-point comparison for hemifields was performed. Results: Each localized response showed a significant aging ...
TY - JOUR. T1 - Age-related effect of cells-donors of nuclei on efficiency of development of cloned rabbit embryos. AU - Lagutina, I. S.. AU - Mezina, M. N.. AU - Prokofev, M. I.. AU - Chernykh, V. Ya. AU - Galat, V. V.. PY - 2001/12/1. Y1 - 2001/12/1. N2 - We studied the capacity of nuclei of rabbit fibroblasts taken from various developmental stages for reprogramming in the cytoplasm of mature aging enucleated oocytes and development of the cloned embryos to the preimplantation stages. A negative correlation was found between the age of an animal-donor of fibroblasts and efficiency of the development of cloned embryos (rmorula-blastocyst = -0.826, rblastocyst = -0.7139). A reliably decreased capacity for reprogramming of the nuclei of donor fibroblasts was shown upon transition from prenatal development to the postnatal one, as well as a trend to a decreased capacity of nuclei for reprogramming during aging. Aging of cells in the culture, at least until the 10th passage, did not affect the ...
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Non-enzymatic protein modifications occur inevitably in all living systems. Products of such modifications accumulate during aging of cells and organisms and may contribute to their age-related functional deterioration. This review presents the formation of irreversible protein modifications such as carbonylation, nitration and chlorination, modifications by 4-hydroxynonenal, removal of modified proteins and accumulation of these protein modifications during aging of humans and model organisms, and their enhanced accumulation in age-related brain diseases.
Healthy aging has been shown to modulate the neural circuitry underlying simple declarative memory; however, the functional impact of negative stimulus valence on these changes has not been fully investigated. Using BOLD fMRI, we explored the effects
PURPOSE: Little research has analyzed mistrust and discrimination influencing receipt of health care services among Latinos, particularly those living in rural areas. The present study examined the associations between medical mistrust, perceived discrimination, and satisfaction with health care among young-adult rural Latinos. RESEARCH DESIGN: This cross-sectional study analyzed data from 387 young-adult Latinos (ages 18-25) living in rural Oregon. The Behavioral Model of Vulnerable Populations was utilized as the theoretical framework. Correlations were run to assess bivariate associations among variables included in the study. Ordered logistic regression models evaluated the associations between medical mistrust, perceived discrimination, and satisfaction with health care. RESULTS: On average, participants used health services 4 times in the past year. Almost half of the participants had health insurance (46%). The majority reported that they were moderately (32%) or very satisfied (41%) with ...
Purpose : Swept source optical coherence tomography angiography (SS-OCTA) was used to measure the age-dependent changes in macular choriocapillaris (CC) flow deficits (FDs) in normal eyes. Methods : Subjects with normal eyes were imaged using a 100-kHz SS-OCTA instrument (PLEXÒ Elite 9000, Carl Zeiss Meditec). Both 3x3 mm and 6x6 mm scans were acquired. Visualization of the CC and quantification of FDs were obtained using a previously validated algorithm. The percentage of FDs (FD%) in the central 1 mm circle (C1), 1.5 mm rim (R1.5), and 2.5 mm circle (C2.5) from the 3x3 mm and 6x6 mm scans and FD% in the 2.5 mm rim (R2.5) and 5 mm circle (C5) from the 6x6 mm scans were measured and correlated with age and axial length. Results : A total of 164 eyes from 164 subjects were enrolled, with at least 10 subjects from each decade of life. Mean axial length was 23.80 ± 1.0 mm. Fifty-six percent of the subjects were women. No meaningful correlations were found between FD% and axial length (,r, , ...
We investigated the influences of short-term and lifespan-prolonging long-term caloric restriction (LCR) on gene expression in white adipose tissue (WAT). Over 11,000 genes were examined using high-density oligonucleotide microarrays in four groups of 10- to 11-month-old male C57Bl6 mice that were either fasted for 18 h before death (F), subjected to short-term caloric restriction for 23 days (SCR), or LCR for 9 months and compared with nonfasted control (CO) mice. Only a few transcripts of F and SCR were differentially expressed compared with CO mice.
As we age and get older our immune system starts to decline in strength and isnt as vigorous as it once was. Because of this Life Extension Immune Senescence Protection Formula has been invented. This formula helps support and strengthens your immune
The first half of the module will explore age related changes in cognitive and moral development from early infancy to late adolescence. It will also consider the other major changes that occur in adolescence including social, biological, and neurological changes and how this might impact on normative development in this sensitive period. The second half will deal with health ageing in comparison to age-related disorders such as mild cognitive impairment and dementia. These issues will be considered in terms of brain anatomy and function as well as the effect on the individual and society. Current methods in ageing and developmental research will also be discussed.. ...
TY - JOUR. T1 - Comparative pharmacokinetics of three doses of percutaneous dihydrotestosterone gel in healthy elderly men - A clinical research center study. AU - Wang, C.. AU - Iranmanesh, A.. AU - Berman, N.. AU - Mcdonald, V.. AU - Steiner, B.. AU - Ziel, F.. AU - Faulkner, S. M.. AU - Dudley, R. E.. AU - Veldhuis, J. D.. AU - Swerdloff, R. S.. PY - 1998/11/10. Y1 - 1998/11/10. N2 - Twenty-five men, 60-80 yr old, participated in a pharmacokinetic study to compare three doses (16, 32, and 64 rag/day, n = 8 or 9 in each group) of 5α-dihydrotestosterone (DHT) gel (0.7% hydroalcoholic gel with 2.3 g gel delivering 16 mg DHT) applied daily over one upper arm (16 mg); both arms and shoulders (32 mg); and bilateral arms, shoulders, and upper abdomen (64 mg), respectively. Multiple blood samples for the pharmacokinetic profile for DHT and testosterone (T) were drawn over a 24-h period before application, after first application, and after 14 days of daily application of DHT gel. Additional blood ...
Researchers at Columbia University Medical Center reversed age-related memory loss in mice by boosting blood levels of osteocalcin, a hormone produced by bone cells.
Elderly men with low levels of testosterone or other sex hormones have twice the likelihood of having declining physical function over two years time compared with their peers who have the highest hormone levels, a new study from Australia finds. The results will be presented Saturday at the joint meeting of the International Society of Endocrinology and the Endocrine Society: ICE/ENDO 2014 in Chicago.
The individual and combined effects of cimetidine and ciprofloxacin on theophylline metabolism were examined in healthy young and elderly male and female nonsmokers. Single-dose studies of theophylline pharmacokinetics were performed at base line and on the fifth day of each of three treatment regimens consisting of 400 mg cimetidine every 12 hr, 500 mg ciprofloxacin every 12 hr and the combination of cimetidine and ciprofloxacin. Base-line theophylline plasma clearance and formation clearance of theophylline metabolites decreased with age in both gender groups to a similar extent (20% less in elderly men than in young men; 24% less in elderly women than in young women). Individually, cimetidine and ciprofloxacin produced proportionate declines in plasma theophylline clearance that were similar among the four groups (range, 23.4-32.7% decrease). The combined regimen yielded further impairment in theophylline elimination compared with each agent alone (range, 35.9-42.6% decrease). Cimetidine was ...
The key new findings from the present study include the following. (1) Healthy but sedentary seniors exhibited substantially greater LV stiffness compared with healthy, sedentary young control subjects, providing evidence that cardiac compliance decreases with aging. (2) Ventricles of Masters endurance athletes were much more compliant than those of the age-matched sedentary subjects and virtually identical to those of the young control subjects. Thus, prolonged and sustained endurance training seems to be an effective means of preserving cardiac compliance with aging.. Aging is associated with numerous changes and adaptations in the cardiovascular system. Vascular and ventricular wall thickness increase, whereas arterial compliance, endothelial function, and ventricular contractility decline.6,8,9 Each of these changes is related to an increase in cardiovascular morbidity and mortality. There is controversy, however, about to what extent these adaptations are of intrinsic nature, ie, part of a ...
Inflammaging and immune senescence mini-review, a new area of research studying the changes in the immune system that occur as people age. Using flow cytometry, the pathological characteristics of aging tissues across multiple species can be identified.
Aging stem cells may play a critical role in determining the effects of aging on organ function. With regard to vascular diseases, it has been postulated that circulating EPCs are involved in the repair mechanisms after endothelial damage (27,28). Ultimately, deterioration of endothelial or vascular function may be related to both quantitative and qualitative changes of stem cells.. We describe here the first comprehensive analysis of the association between age-related endothelial dysfunction and the number and function of circulating EPCs, defined by expression of CD34+/VEGFR2+ and CD133+/VEGFR2+. Although no quantitative differences in EPCs were observed, our data illustrate that culture-enriched EPCs from old but otherwise healthy subjects are impaired in terms of fundamental functional features like proliferation (important for amplifying the cellular pool), migration (critical for homing of circulating EPCs), and survival. We demonstrate a significant univariate correlation between the ...
Deficiency of the fast-twitch muscle protein alpha-actinin-3 due to homozygosity for a nonsense polymorphism (R577X) in the ACTN3 gene is common in humans. alpha-Actinin-3 deficiency (XX) is associated with reduced muscle strength/power and enhanced endurance performance in elite athletes and in the general population. The association between R577X and loss in muscle mass and function (sarcopenia) has previously been investigated in a number of studies in elderly humans. The majority of studies report loss of ACTN3 genotype association with muscle traits in the elderly, however, there is some indication that the XX genotype may be associated with faster muscle function decline. To further explore these potential age-related effects and the underlying mechanisms, we examined the effect of alpha-actinin-3 deficiency in aging male and female Actn3 knockout (KO) mice (2, 6, 12, and 18 months). Our findings support previous reports of a diminished influence of ACTN3 genotype on muscle performance in the
Age-related gene response of human corneal endothelium to oxidative stress and DNA damage. Invest Ophthalmol Vis Sci. 2011 Mar 01; 52(3):1641-9 ...
ABSTRACTInsulin-like growth factor-I (IGF-I) clearly plays a role in bone metabolism and maintenance, as evidenced by in vitro and animal studies. In clinical studies, the age-related decrease in IGF-I parallels the age-related decrease in bone mineral density (BMD), but several age-adjusted cross-s
TY - JOUR. T1 - Age-related increase of airway neutrophils in older healthy nonsmoking subjects. AU - Pignatti, Patrizia. AU - Ragnoli, Beatrice. AU - Radaeli, Alessandro. AU - Moscato, Gianna. AU - Malerba, Mario. PY - 2011/8/1. Y1 - 2011/8/1. N2 - Background: Although an influence of advancing age on lung cellularity in healthy subjects has already been described, induced sputum reference values for cell counts in older healthy adults are not available. The aim of the present study was to evaluate the influence of age on the variation of sputum cell distribution in a considerable number of healthy subjects. A total of 70 nonatopic, nonsmoker healthy subjects aged ≥50 years underwent sputum induction and blood cell count. Sputum samples were processed and then were analyzed by optical microscopy. Differential cell counts were reported as percentages and amount of cells/mg. Results: Sputum cell distribution of healthy subjects aged ≥50 years was mainly composed of neutrophils. Both the ...
Immunosenescence refers to the gradual deterioration of the immune system brought on by natural age advancement. It involves both the hosts capacity to respond to infections and the development of long-term immune memory, especially by vaccination. This age-associated immune deficiency is ubiquitous and found in both long- and short-living species as a function of their age relative to life expectancy rather than chronological time. It is considered a major contributory factor to the increased frequency of morbidity and mortality among the elderly. Immunosenescence is not a random deteriorative phenomenon, rather it appears to inversely repeat an evolutionary pattern and most of the parameters affected by immunosenescence appear to be under genetic control. Immunosenescence can also be sometimes envisaged as the result of the continuous challenge of the unavoidable exposure to a variety of antigens such as viruses and bacteria. Immunosenescence is a multifactorial condition leading to many ...
The incidence of VTE is significantly lower in children compared with adults, suggesting the presence of protective mechanisms [11]. In children, the coagulation system develops with age, as evidenced by significant age-related differences in the concentration of most clotting factors, a concept known as developmental hemostasis [11].. In a nationwide epidemiologic study in the Korean population, the annual incidence of VTE in 2008 was reported as 13.8 cases per 100,000 individuals [12], which is significantly lower than the annual incidence noted for the Caucasian population (143 cases per 100,000 individuals) [13]. Furthermore, the incidence of VTE in Korean youth was even lower, with a reported 0.09 cases per 10,000 individuals aged 0-19 years [12].. In our study, the incidence of VTE was 3.27 cases per 10,000 pediatric patients. This rate was higher than the previously reported VTE incidence in the general Korean pediatric population but was lower than the incidence reported from Western ...
Alzheimers disease (Advertisement) can be an age-associated disease seen as a increased build up of extracellular -amyloid (A) plaques within the mind. a crucial developmental period at six months where cells remain in a position MK-2866 to connect to A fibrils but drop their capability to phagocytose it. and so are maintained inside a basally reactive phenotype [31C33]. Consequently, adult microglia instead of early postnatal microglia may provide a even more relevant model for determining the complete microglia-A conversation during disease. Many studies have recorded that acutely isolated adult microglia from rodent brains maintain a quiescent phenotype although long term culturing ultimately prospects to activation [23, 34C38]. To be able to better define whether an age-dependent switch in microglial A conversation is present, microglia acutely isolated from differing age group C57BL/6 mouse brains had been utilized to examine not merely degrees of putative A receptors, but moreover, ...
As PS1 is an integral protein of the γ-secretase complex, its stoichiometry may play an important role in balanced processing of APP. A decrease in PS1 (Refolo et al., 1999) or inactivation by mutations (Sudoh et al., 1998) may be associated with increased Aβ42. We had previously noticed an increase in APP as well as Aβ1-42 with age in SAMP8 mice (Morley et al., 2000), suggesting that a decrease in PS1 may cause increased aberrantγ -secretase activity. Accumulation of Aβ is attributed to loss of memory, as reduction of APP expression reverses this loss (Kumar et al., 2000). Therefore, reduction in APP expression is one of the pharmaceutical approaches to counter age-dependent or neurodegenerative disorders like AD that involve memory loss. Being an essential component of γ-secretase, PS1 is another therapeutic target for reducing Aβ formation. As SAMP8 mice have been shown to exhibit memory loss at a relatively early age (Flood and Morley, 1998; Miyamoto, 1997), we have studied the ...
As shown in Table 1, at 9 months of age, we observed a decline in GFR and renal plasma flow in the animals which ingested the lipid-rich diets, and in 18-month-old rats, the fish oil and butter groups showed a significant decrease in those parameters when compared to the control group at the same age; if corrected for kidney weight, these differences were still present; for example, GFR was 1.95 ± 0.11 in controls, 0.95 ± 0.04 in the butter group, 1.04 ± 0.17 in the fish oil group and 1.33 ± 0.29 ml min-1 g-1 in the canola oil group, confirming that the age-dependent decline in renal function was accelerated by the ingestion of LD. The complex mechanism by which lipids aggravate renal diseases is not well understood. Factors such as intraglomerular macrophage infiltration, increased glomerular capillary pressure and the degree of lipoprotein oxidation have been claimed to be major determinants of the progression of glomerulosclerosis (5-7). However, the controversy about the effects of ...
The present invention is a method for analyzing the biological age of a subject. The method analyzes the biological age as it relates to a number of factors indicating levels of health, energy production and metabolism. The method may also be used to calculate a subjects biological age and treat the factors associated with biological age.
With extension of the average lifespan, the ageing population has become a heavy burden for both society and individuals. Immune responses, key for the removal of pathogens and damage, are compromised in the elderly, making the elderly more susceptible to infections. In addition immune senescence is a risk factor for many late-onset diseases, such as cancer and atherosclerosis. Autophagy through degrading bulk cytoplasmic material maintains cytoplasmic health and cellular homeostasis [1]. We have found that it allows differentiation of immune cells [2] [3]. In previous work we showed that loss of autophagy in macrophages results in low-grade inflammation (inflamm-aging) and reduces innate and adaptive immune responses, typical of a senescent immune system. Autophagy induction rejuvenates immune responses in the elderly in T cells [3]. We have recently uncovered a novel pathway that controls the translation of autophagy proteins in T and B lymphocytes. Lymphocytes from old mice and elderly humans ...
This two-part study is assessing the pharmacokinetics and effects on age-related cognitive decline of GSK-2981710 (medium chain triglycerides) in elderly
https://doi.org/10.18632/oncotarget.6168 Po-Hsiang Liao, Dennis Jine-Yuan Hsieh, Chia-Hua Kuo, Cecilia-Hsuan Day, Chia-Yao Shen, Chao-Hung Lai, Ray-Jade Chen, V. Vijaya Padma, Wei- Wen Kuo,...
Molecular Cardiology, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MADepartment of Orthopedic Surgery, Brigham and Womens Hospital, Harvard Medical School, Boston, MA ...
Background With increasing age neuromuscular deficits (e.g., sarcopenia) may result in impaired physical performance and an increased risk for falls. Prominent intrinsic fall-risk factors are age-related decreases in balance and strength / power performance as well as cognitive decline. Additional studies are needed to develop specifically tailored exercise programs for older adults that can easily be implemented into clinical practice. Thus, the objective of the present trial is to assess the effects of a fall prevention program that was developed by an interdisciplinary expert panel on measures of balance, strength / power, body composition, cognition, psychosocial well-being, and falls self-efficacy in healthy older adults. Additionally, the time-related effects of detraining are tested.. Methods/Design Healthy old people (N = 66) between the age of 65 to 80 years will participate in this trial. The testing protocol comprises tests for the assessment of static / dynamic steady-state balance ...
What is it? The aging eye can be affected in many different ways. One of them being the formation of a cataract or clouding of the normal human crystalline lens. The other common age related change affecting the eye is called age related macular degeneration (AMD). This condition usually affects people in the 6th or 7th decade of life, but may occur in the younger population.. This condition affects the area at the back of the eye, responsible for the central part of the vision, the macula (see Eye anatomy). Degeneration, or breakdown of this part of the retina causes loss of central vision, and is one of the most common causes of legal blindness in South Africa, and the world. Most patients retain some form of peripheral vision, but overall prognosis in late / advanced AMD can be very poor.. What is DRY and WET AMD? Dry AMD is the more common form and is also referred to as atrophic or non-exudative AMD. There is formation of drusen beneath the macula that build up and eventually causes ...
The aim of this doctoral thesis was to investigate and to understand the implication of oxidative stress, created by the interplay of ionizing (X-ray) radiation, oxygen and neurotoxic amyloid beta (Aβ) peptide, in age-associated diseases, with the focus on Alzheimer´s disease (AD), the most common dementia. Although AD has been known for more than hundred years, its mechanisms are still intriguing and there is no cure at the moment. High doses of ionizing radiation (IR) lead to learning and memory impairment which is characteristic for AD as well. The cumulative doses of IR used in medical imaging procedures such as computed tomography (CT) and dental X-rays present a potential danger, particularly to children whose brains are not completely developed. Although single doses of radiation used for diagnostic purposes or therapeutic treatment are relatively low, small changes on the molecular and cellular level may accumulate upon repeated exposure and result in delayed long-term defects. Thus, ...
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Authors: Stepanichev, Mikhail , Onufriev, Mikhail , Aniol, Viktor , Freiman, Sofia , Brandstaetter, Hemma , Winter, Stefan , Lazareva, Natalia , Guekht, Alla , Gulyaeva, Natalia Article Type: Research Article Abstract: Background: Aging is associated with some cognitive decline and enhanced risk of development of neurodegenerative diseases. It is assumed that altered metabolism and functions of neurotrophin systems may underlie these age-related functional and structural modifications. CerebrolysinTM (CBL) is a neuropeptide mixture with neurotrophic effects, which is widely used for the treatment of stroke and traumatic brain injury patients. It is also evident that CBL has an overall beneficial effect and a favorable benefit-risk ratio in patients with dementia. However, the effects of CBL on cognition and brain neurotrophin system in normal aging remain obscure. Objective: The aim …of the present study was to examine the age-related modifications of endogenous neurotrophin systems in the ...
TY - CHAP. T1 - Aging-associated alterations in myocardial inflammation and fibrosis. T2 - Pathophysiological perspectives and clinical implications. AU - Shinde, Arti V.. AU - Frangogiannis, Nikolaos G.. PY - 2014/1/1. Y1 - 2014/1/1. N2 - Senescent hearts exhibit structural and molecular changes that result in impaired function and are associated with diminished ability to meet increased demand. Both animal model studies and clinical investigations suggest that fibrosis is a hallmark of cardiac aging. Expansion of the cardiac interstitium and accumulation of collagen in the aging heart cause a progressive increase in ventricular stiffness, contributing to impaired diastolic function. Increased mechanical load due to increased vascular stiffness and direct activation of senescence-associated fibrogenic signals in the myocardium are implicated in the pathogenesis of cardiac fibrosis in the elderly. Reactive oxygen species (ROS), chemokine-mediated recruitment of mononuclear cells and fibroblast ...
TY - CHAP. T1 - Effect of aging on changes of nociception and Cav2α1 expression patterns in seven inbred mouse strains. AU - Takahashi, Eiki. PY - 2012/8. Y1 - 2012/8. N2 - The depolarization induced by Cav2 decreases and pain threshold increases with aging. To characterize strain dependence of age-related changes in nociception and spinal expression of Cav2 in mice, we evaluated nociceptive sensitivity and Cav2α1 mRNA expression in 2-month-old and 20-month-old mice of seven inbred strains (A/J, AKR/N, BALB/c, C3H/HeJ, C57BL6/J, DBA/2, 129/SvJ). In the hot plate test, 20-month-old C3H/HeJ showed reduced thermal nociceptive thresholds relative to 2-month-old mice, but no difference was observed between 2-month-old and 20-month-old mice of other strains. In the formalin paw test, there was no difference in licking/biting time in phase 1 between 2-month-old and 20-month-old animals of any strain, but the phase 2 responses in 20-month-old C3H/HeJ and DBA/2 were decreased compared with those of ...
Analysis of mitochondrial function in tissues, such as the skeletal muscle of older subjects, reveals a decline in mitochondrial respiratory capacity to roughly 50% of what is seen in younger subjects and a reduction in ATP (63, 64). These mitochondrial deficits track closely with functional decline in muscle strength and are believed by most to be a causal factor for age-related sarcopenia (65). While, as mentioned above, in certain rare cases, accumulation of mtDNA mutations might contribute to this functional deficit, it is likely that other mechanisms are at play. An increase in the steady-state levels of dysfunction could be due to an increase in age-dependent damage to mitochondria, an age-dependent decline in the removal of dysfunctional mitochondria, or some combination of both mechanisms. The removal of damaged but intact mitochondria occurs through the process of mitophagy. We have already briefly discussed this process in the setting of inflammasome activation, where mitophagy, by ...