TY - JOUR. T1 - Age-associated Differences in Cardiovascular Inflammatory Gene Induction during Endotoxic Stress. AU - Saito, Hiroshi. AU - Papaconstantinou, John. PY - 2001/8/3. Y1 - 2001/8/3. N2 - Upon physiological stress, families of stress response genes are activated as natural defense mechanisms. Here, we show that induction of specific inflammatory genes is significantly dysregulated and altered in the heart of aged (24-26-month-old) versus young (4-month-old) mice experimentally challenged with a bacterial endotoxin, lipopolysaccharide (LPS, 1.5 mg/kg of body mass). Whereas the LPS-mediated induction of cardiac mRNA for tumor necrosis factor α or inducible nitric-oxide synthase showed no age-associated differences, the induction of interleukin-1β (IL-1β) and intracellular adhesion molecule-1 was modestly extended with aging, and the induction of IL-6 was significantly prolonged with aging. This age-associated phenomenon occurred gradually from 4 to 17 months of age and became more ...
Musculoskeletal conditions are a major burden on individuals, healthcare systems, and social care systems throughout the world, with indirect costs having the predominant economic impact. Aging is a major contributing factor to the development and progression of arthritic and musculoskeletal diseases. Indeed, aging and inflammation (often referred to as inflammaging) are critical risk factors for the development of osteoarthritis (OA), which is one the most common forms of joint disease. The term chondrosenescence has recently been introduced to define the age-dependent deterioration of chondrocyte function and how it undermines cartilage function in OA. An important component of chondrosenescence is the age-related deregulation of subcellular signalling pathways in chondrocytes. This mini-review discusses the role of age-related alterations in chondrocyte signaling pathways. In this article we focus our attention on two major areas: age-dependent alterations in transforming growth factor-β ...
Investigations of intracellular signaling revealed reduced phosphorylation of AKT in MDDCs from aging, suggesting decreased activation of PI3kinase signaling pathway. Since PI3K signaling pathway plays a positive regulatory role in phagocytosis and migration, and it also functions as a negative regulator of TLR signaling by inducing activation of p38 MAP kinase, this may explain the aberrant innate immune functioning of DCs from aged subjects. Results further revealed an increased expression of PTEN, a negative regulator of PI3Kinase signaling pathway, in MDDCs from aged subjects. Increased PTEN may thus be responsible for the defect in AKT phosphorylation and therefore, altered innate immune response of DCs from aged humans.. This study is supported in part by a grant AG027512 from NIH and partly by new scholar grant from the Ellison Medical Foundation. ...
Voltage-gated sodium channels (VGSCs) generate the Na+ current (INa) responsible for the cardiac action potential upstroke largely due to the cardiac isoform Nav1.5, but other isoforms are responsible for ˜20% of the upstroke and a component of a sustained sodium current. This sustained component has been attributed with an increasing arrhythmia risk, particularly within the elderly and has been the target of development for new anti-arrhythmic drugs. Our study has investigated the age-associated changes in protein density and localisation of the VGSC alpha-subunits Nav1.5 and Nav1.4 in the rat heart.. Rats at 6, 12 and 28 months of age were sacrificed, their hearts dissected into the regions of left and right ventricle, left and right atria, epicardium and endocardium (n = 5). These regions were analysed by western blot to determine the protein expression of Nav1.5 and Nav1.4 (Alomone, Israel), normalised to the expression of desmin (Dako, UK). Immunocytochemistry of single cardiac myocytes ...
Researchers at Mayo Clinic have shown that eliminating cells that accumulate with age could prevent or delay the onset of age-related disorders and disabilities. The study, performed in mouse models, provides the first evidence ...
Greater social contact and support are associated with better cognitive functioning, whereas greater conflict is associated with lower cognitive functioning.. Diseases either caused by or associated with aging - particularly vascular changes - play a larger role in age-related cognitive changes than is often acknowledged.. This collection of articles, titled Cognition, Health, and Aging: Integrating Perspectives Across Disciplines, is based on papers presented at a conference held at Penn State University in 2009. Funding for the supplemental issue was provided by the National Institute on Aging through the resources of the Center on Population Health and Aging at Penn State University, and the National Academies Keck Futures Initiative grant, Health and Healthspan in Longitudinal Studies of Aging.. The Journals of Gerontology Series B: Psychological Sciences and Social Sciences is a refereed publication of The Gerontological Society of America (GSA), the nations oldest and largest ...
BACKGROUND. Cancer incidence typically increases with age, but it is not known whether ethnic characteristics influence the age dependence of squamous cell carcinoma of the skin (SCC). OBJECTIVES. (i) To determine the age dependence of SCC in the black African, coloured and white population groups of South Africa (SA); and (ii) to show whether any differences in the rate of change of age dependence could be influenced by diversity in behaviour and lifestyle, especially with regard to the prevalence of HIV infection, rather than by a fundamental variation in cancer biology between the populations. METHODS. Linear regression analysis was applied to the logarithm of the age-specific incidence rates for SCC v. the logarithm of age between 35 and 74 years. The slopes of the regression (age exponent) were compared for each subset of gender, population group and year of diagnosis (between 2000 and 2010). RESULTS. The most notable feature was the low value of the age exponent in both male and female ...
Age-related effects on the default mode network (DMN) connectivity as measured at rest using functional magnetic resonance imaging (fMRI) are now well described. Little is known however about the relationships between these changes and age-related effects on cognition or on the unconstrained thoughts which occur during the resting-state scan, called inner experience. Brain resting-state activity, inner experience, and cognitive ability measurements were obtained in 70 participants aged 19-80 years. The anterior-posterior disruption of DMN activity with age reported in previous studies was recovered here. A significant effect of age was also found on cognitive abilities but not on inner experience. Finally, age-related changes in DMN connectivity were found to correlate with cognitive abilities, and more specifically with autobiographical memory performance. These findings provide new information to fuel the debate on the role of the brain default mode and more specifically on the effect of age-related
The retinal hypoperfusion found in the present study is also in support of the cerebral hypoperfusion, which occurs during normal aging (Table 4).1,5,11,22 Chen et al.1 studied the age-related reduction of CBF during normal aging in a cohort of normal subjects and found that the CBF as an indirect measurement of brain perfusion declined at a rate of −0.38% per year when the entire cortex was examined. Meanwhile, the cortical grey matter volume decreased at a rate of −0.85% per year, which exceeds the reductions in CBF.1 Leenders et al.5 reported that the CBF, cerebral blood volume, and cerebral metabolic rates of oxygen decline at a rate of −0.5% per year during normal aging. The changing rate of the RTP (−0.47% per year), RBF (−0.41% per year), and VVDd (−0.44% per year) found in the present study well matches the CBF change rates reported by Chen et al.1 and Leenders et al.,5 indicating that the RTP, RBF, and VVDd may be good candidates for imaging markers of the age-related ...
Huber, N., Sakai, N., Eismann, T., Shin, T., Kuboki, S., Blanchard, J., Schuster, R., Edwards, M. J., Wong, H. R. and Lentsch, A. B. (2009), Age-related decrease in proteasome expression contributes to defective nuclear factor-κB activation during hepatic ischemia/reperfusion. Hepatology, 49: 1718-1728. doi: 10.1002/hep.22840 ...
Age-related alterations in brain structure and function have been challenging to link to cognition due to potential overlapping influences of multiple neurobiological cascades. We examined multiple brain markers associated with age-related variation in cognition. Clinically normal older humans aged 65-90 from the Harvard Aging Brain Study (N = 186) were characterized on a priori magnetic resonance imaging markers of gray matter thickness and volume, white matter hyperintensities, fractional anisotropy (FA), resting-state functional connectivity, positron emission tomography markers of glucose metabolism and amyloid burden, and cognitive factors of processing speed, executive function, and episodic memory. Partial correlation and mediation analyses estimated age-related variance in cognition shared with individual brain markers and unique to each marker. The largest relationships linked FA and striatum volume to processing speed and executive function, and hippocampal volume to episodic memory. ...
In the past two decades neuroimaging studies have tried to unveil the neural mechanisms behind age-related changes in cognitive strategies and performance. Structural imaging studies have shown that brain volume changes throughout the complete life-span and functional imaging studies have reported age-related differences in brain activation and connectivity. ... read more The aim of this thesis was to provide an overview of studies that report age-related changes in brain activation as measured with functional MRI in a longitudinal design in healthy subjects. We found 16 studies of which 11 reported changes in activity over time. The majority of studies was performed in children. fMRI task used varied between attention, language, memory, working memory and sensory processing tasks. We found increases and decreases in activation in children between 5 and 20 and adults above age 50. A trend of left-hemispheric increases were shown for children around age 8, adults around age 66 and in language ...
After exclusion of.... confounders, most studies show similar results: A clear, age-dependent decline in serum Thyroid Stimulating Hormone (TSH) and (free) T3 ....[2] In the elderly, Thyroid hormones levels are usually within the lower part of normal values reported in the general population.[4] There is evidence that the decreased thyroid hormone levels observed in aging are due to lower TSH concentrations, and that lower TSH concentrations may be linked to an impaired pituitary activity.[5] But, as mentioned in the previous paragraph, T4 to T3 conversion is vital as well, with the net result of this decreased de-iodination with advancing age is a clear, age-dependent decline in total and free T3 levels...[2] ...
Age is the single greatest risk factor in the development of the blinding eye disease AMD where the prevalence of disease significantly increases as individuals enter their sixth decade. 2,3 In spite of this universal observation, other factors that lead to increased disease incidence remain undefined. Increases in damage from environmental stresses, accumulation of damaged proteins and organelles, and loss of function in important biochemical pathways all have been proposed. 3,4,13,52 The immune system is also thought to have a role in disease development 12-14,53 ; however, few studies have addressed how age-related changes in the immune response could be involved. The eye also is an immune privileged organ that can have a strong inhibitory influence on inflammatory and neovascular responses via a number of immunosuppressive mediators. 21 How age-dependent changes in the immune system are influenced by immune privilege and how age might alter the function of immune privilege is currently ...
In this report, we demonstrated that loss of function mutations in Popdc1 and Popdc2 genes in mice are associated with stress-induced SND, resulting in chronotropic incompetence and long sinus pauses. The Popdc genes displayed overlapping myocardial expression patterns and similar biochemical properties, and the cardiac phenotypes of the null mutants were nearly identical. Our data suggest that Popdc proteins represent a novel class of cAMP binding proteins that interact with TREK-1 channels and may be involved in channel trafficking. Age-dependent decline in cardiac pacemaking in Popdc null mutants. Both mouse mutants developed SND at advanced age. Assuming that Popdc genes act in the same pathway, loss of a single gene might not have a significant impact on function in the young, since both Popdc genes might be able to substitute for each other. Obviously, the compensation became less efficient when the null mutants aged, possibly due to an age-dependent decline of Popdc expression. ...
The diversity of the human TCR repertoire in aging has been studied by examining the profiles of complementarity-determining region 3 (CDR3) sizes expressed by the BV families. The TCRBV CDR3 profile, which shows size heterogeneity in young adult humans, is significantly restricted in aged humans. Clonal T cell expansions were identified using a PCR-based approach, in one or more BV families from all 14 healthy persons over the age of 65 that we studied. CD4+ T cell expansions were identified in 8 of 11 donors and CD8+ T cell expansions in 7 of 10 donors. These clonal expansions were stable during a 2-year period. Interestingly, more than half of the aged persons had clonal expansions within the BV3, -14, -16, and -23 families. Although there was no homology among the eight CDR3 sequences identified in clonal T cells from 8 aged persons, selective pressure on the expanded T cell clones was suggested by the fact that the BV families used by the T cell clones were not proportional to the number of ...
Immune aging may underlie various aging-related disorders, including diminished resistance to infection, chronic inflammatory disorders, and autoimmunity. PD-1+ and CD153+ CD44high CD4+ T cells with features of cellular senescence, termed senescence-associated T (SA-T) cells, increasingly accumulate with age and may play a role in the immune aging phenotype. In this article, we demonstrate that, compared with young mice, the aged mouse environment is highly permissive for spontaneous proliferation of transferred naive CD4+ T cells, and it drives their transition to PD-1+ and CD153+ CD44high CD4+ T cells after extensive cell divisions. CD4+ T cells with essentially the same features as SA-T cells in aged mice are also generated from naive CD4+ T cells after extensive cell divisions under severe T-lymphopenic conditions by gamma irradiation or in developmental T cell defect, often in association with spontaneous germinal centers, as seen in aged mice. The increase in SA-T cells is significantly enhanced
Geoffroy CG, Hilton BJ, Tetzlaff W, Zheng B How aging impacts axon regeneration after CNS injury is not known. We assessed the impact of age on axon regene …
TY - JOUR. T1 - Analysis of the age-related refractoriness of T-lymphocyte reactivity in humans. AU - Bátory, Gabriella. AU - Ónody, Clara. AU - Petrányi, G. Gy. PY - 1981/4. Y1 - 1981/4. N2 - Aged individuals could be divided into two groups according to their T-lymphocyte transformation values. The relationship between the PHA (phytohemagglutinin) stimulation indices and spontaneous thymidine incorporation; the PHA dose-response type distribution and the relative number of resting T lymphocytes was similar to the control group in aged subjects of seemingly intact T lymphocyte transformation values. However, their B cell compartment was found to be reduced. On the other hand, the ratio between the stimulation indices and spontaneous thymidine incorporation values of aged subjects of impaired T lymphocyte reactivity deviated from that of the control group. This group had an increased frequency of subjects giving maximal transformation values at relatively high PHA doses (hyposensitives) at ...
Cardiovascular System ✓ Gastrointestinal System ✓ Genitourinary System ✓ Musculoskeletal System ✓ Nervous System ✓ Sensory Changes ✓ Endocrine System ✓ Integum...
Umbilical cord blood from human newborns, and in particular a single protein contained in it, boosted old mices brain function and cognitive performance
The present study tested whether aging alters endotoxin-induced myocardial dysfunction in a sublethal model of endotoxemia in rats. The main findings were the following: 12 hours after LPS injection (0.5 mg/kg), a marked reduction in myocardial contractility was observed in the isolated perfused senescent heart; in contrast with septic cardiac dysfunction in young rats, myofilament Ca2+ sensitivity of left ventricular skinned fibers was not reduced in senescent rats; and NO production, oxidative stress, and antioxidant enzymes activities were not different between young adult and senescent LPS groups. Thus, despite similar alterations in potential mediators, cellular mechanisms responsible for this contractile dysfunction are different between young adult and senescent rats. More specifically, myofilament Ca2+ responsiveness remains unaltered in the senescent heart. This may have clinical implications for management of elderly septic patients.. Nonlethal models of endotoxemia have allowed ...
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First, we found that the level of soluble HS is positively correlated with age in vitreous samples from idiopathic maculopathies. We then showed that soluble HS levels in aqueous humor were lower in younger diabetic subjects with retinal NVs than in older diabetic subjects without retinal NVs or in nondiabetic subjects with cataract; the difference was no longer significant after controlling for the ages in these groups. The lack of correlation between severity of retinopathy and HS levels suggests that reduced HS levels in the aqueous humor in younger PDR patients could be explained at least in part by age and not by the severity of retinopathy. While the observation appears to contradict the reported correlation between reduced HS levels in the kidney and the diabetes mellitus [16-18], our study does not exclude the possibility of a less significant contribution of diabetes mellitus to ocular levels of HS. Analysis of the intraocular fluid from nondiabetic controls age-matched for PDR and a ...
Various age-related changes in the biomechanics and topography of different ocular components have been reported in the literature. Albon et al. (2000) observed a decrease in both the mechanical compliance and resilience of the human lamina cribrosa with age, and similar observations were made by Krag et al. (1997) in the lens capsule. Strong association was found between the age-related alterations in the optic nerve head and its increased susceptibility to glaucomatous damage (Burgoyne & Downs 2008). The asphericity of both the anterior and posterior corneal surfaces was reported to undergo significant changes with age, leading to a more spherical topography (Lam & Douthwaite 2002) and peripheral thinning (Dubbelman et al. 2006). Stiffening and increased tensile strength of the sclera were also found to be strongly associated with age (Avetisov et al. 1983; Schultz et al. 2008). Where an explanation was provided for these changes, it was the age-related increase in the intermolecular and ...
Evidence for age-dependent impairment of ovalbumin heterogeneous nuclear RNA (HnRNA) processing in hen oviduct.: The expression of the ovalbumin gene in hen ovi
Coenzyme Q10 supplementation reverses age-related impairments in spatial learning and lowers protein oxidation - Age (Dordr). 2013 Oct;35(5):1821-34 - the current study assessed the effect of CoQ intake in older mice for which cognitive and psychomotor impairments were already evident. Separate groups of young (3.5 months) and relatively old mice (17.5 months) were fed a control diet or a diet supplemented with low (0.72 mg/g) or high (2.81 mg/g) concentrations of CoQ for 15 weeks. After 6 weeks, the mice were given tests for spatial learning (Morris water maze), spontaneous locomotor activity, motor coordination, and startle reflex. Age-related impairments in cognitive and psychomotor functions were evident in the 17.5-month-old mice fed the control diet, and the low-CoQ diet failed to affect any aspect of the impaired performance. However, in the Morris water maze test, old mice on the high-CoQ diet swam to the safe platform with greater efficiency than the mice on the control diet. The old ...
This data collection contains data gathered in a longitudinal study of a sample of men aged 65 to 92 who were in good health during the first wave of the study in 1957. The chief aim of the study was to focus on the nature of the normal aging process in individuals of advanced age. The 47 study participants had not suffered from accidents, illnesses, severe emotional or personality problems, or environmental difficulties that might have led to premature aging, but 20 participants showed evidence of asymptomatic subclinical disease. This group represented the typical or average healthy aged individual with minimal degrees of physical pathology. Five years later, in 1962, a follow-up study was conducted with 29 of the 39 men still alive. The second follow-up, done in 1968, involved 19 of the surviving 23 men. The data are arranged in files by year: 1957, 1962, and 1968. Included are psychiatric data and medical evaluative data as well as various psychological and medical test scores (e.g., ...
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
The effects of the co-agonist of the N-methyl-d-aspartate receptor (NMDAr) d-serine on glutamatergic neurotransmission and synaptic potentiation were studied in the CA1 hippocampal field of young (3-5 months old) and aged (25-27 months old) Sprague-Dawley rats using ex vivo extracellular electrophysiological recording techniques. Exogenous d-serine depressed fast neurotransmission mediated by the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid/kainate subtype of glutamate receptors in young but not in aged rats by acting on inhibitory glycinergic interneurons. In contrast, d-serine dose-dependently enhanced NMDAr-mediated synaptic responses in both groups of animals, but with a larger magnitude in aged rats, thus preventing the age-related decrease in NMDAr activation. d-serine also increased the magnitude of long-term potentiation in aged but not in young rats. Finally, d-serine levels were dramatically reduced in hippocampal tissues of aged rats. Taken together, these results indicate a ...
Background: Acute lung injury (ALI) is a significant source of morbidity and mortality in critically ill patients. Age is a major determinant of clinical outcome in ALI. The increased ALI-associated mortality in the older population suggests that there are age-dependent alterations in the responses to pulmonary challenge. The objective of this observational study was to evaluate age-dependent differences in the acute (within 6 hours) immunological and physiological responses of the heart and lung, to pulmonary challenge, that could result in increased severity. Methods: Male C57Bl/6 mice (young: 2-3 months, old: 18-20 months) were challenged intratracheally with cell wall components from Gram-positive bacteria (lipoteichoic acid and peptidoglycan). After 6 hours, both biochemical and physiological consequences of the challenge were assessed. Alveolar infiltration of inflammatory cells and protein, airspace and blood cytokines, cardiac function and myocardial proteasome activity were determined. Results:
Fatty acid (FA) uptake and/or intramuscular triglyceride (TG) accumulation in skeletal muscle are increased in obesity, type 2 diabetes and aging. FA translocase (FAT/CD36) translocation, lipin-1 subcellular localization and nuclear factor kappa B (NF-κB) p65 protein content in quadriceps muscle of …
2 Research Group Leaders in Ageing-related Diseases & Molecular Mechanisms of Ageing, with Institute of Molecular Biology gGmbH (IMB). Apply Today.
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Chair: Juulia Jylhävä. Markers of biological age have recently proven to be strong mortality predictors independent of other risk factors. As individuals with the same chronological age can vary substantially for their biological age it has become a pressing issue to find the determinants for biological age. This symposium presents findings on the genetic and environmental influences to the following markers of biological age: self-rated health, the frailty index, the epigenetic clock and telomere length. Using unique longitudinal twin cohorts with wide age ranges, we are also able to assess the changes in the contributing sources variation - i.e., genetics and shared and unique environments. The first paper demonstrates how the heritability of self-rated health is influenced by financial strain. The second paper examines if the polygenic risk scores for well-being are predictive of objective (i.e. frailty and multi-morbidity) and subjective indicators of age-related health (e.g. ...
Recent statistics indicate that the human population is ageing rapidly. Healthy, but also diseased, elderly people are increasing. This trend is particularly evident in Western countries, where healthier living conditions and better cures are available. To understand the process leading to age-associated alterations is, therefore, of the highest relevance for the development of new treatments for age-associated diseases, such as cancer, diabetes, Alzheimer and cardiovascular accidents. Mechanistically, it is well accepted that the accumulation of intracellular damage determined by reactive oxygen species (ROS) might orchestrate the progressive loss of control over biological homeostasis and the functional impairment typical of aged tissues. Here, we review how epigenetics takes part in the control of stress stimuli and the mechanisms of ageing physiology and physiopathology. Alteration of epigenetic enzyme activity, histone modifications and DNA-methylation is, in fact, typically associated with the
Recent statistics indicate that the human population is ageing rapidly. Healthy, but also diseased, elderly people are increasing. This trend is particularly evident in Western countries, where healthier living conditions and better cures are available. To understand the process leading to age-associated alterations is, therefore, of the highest relevance for the development of new treatments for age-associated diseases, such as cancer, diabetes, Alzheimer and cardiovascular accidents. Mechanistically, it is well accepted that the accumulation of intracellular damage determined by reactive oxygen species (ROS) might orchestrate the progressive loss of control over biological homeostasis and the functional impairment typical of aged tissues. Here, we review how epigenetics takes part in the control of stress stimuli and the mechanisms of ageing physiology and physiopathology. Alteration of epigenetic enzyme activity, histone modifications and DNA-methylation is, in fact, typically associated with the
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Aged rats (22 to 24 months) and young control rats (3 months) were tested in a battery of behavioral tests which included tests of learning, place navigation, sensorimotor integration, motor coordination, activity, and exploration. Following testing all animals were analyzed in an unanesthetized state for their local glucose utilization. Significant differences in glucose utilization were found between the aged and young groups on some behaviors and in some brain regions. There was considerable variability in the aged group in both their behavioral performance and their glucose utilization scores; thus, attempts were made to determine whether the variability in the degree of impairment within any particular behavioral test was correlated to the regional glucose utilization scores in any of the 45 brain regions analyzed. In two of the behavioral tests employed (i.e., one for learning and one for place navigation), the decline in performance correlated significantly with the decrement in regional ...
Matsuzawa, T and Cinader, B, Polymorphism of age-dependent changes in the production of a thf helper factor. (1982). Subject Strain Bibliography 1982. 2609 ...
Age-dependent changes in the exocytotic efficacy in Kir6.2 ablated mouse pancreatic β-cells. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
Reduced volume, or atrophy, in parts of the brain known as the amygdala and hippocampus may predict which cognitively healthy elderly people will develop dementia over a six-year period, according to a study.
Impaired energy production in older neurons may help explain why human brains are so vulnerable to age-related diseases, according to a new study at Salk Institute in California.. The scientists used a new strategy to discover that cells from older people had dysfunctional mitochondria - the power stations of cells - and lower energy production.. Mitochondria are responsible for converting our food into chemical energy our cells can use. Defects in mitochondrial genes can lead to disease, but researchers also know that mitochondria become less efficient with age and can drive age-related disorders, such as Alzheimers and Parkinsons.. Studying the impact of aging on mitochondria could help researchers gain a better understanding of the known link between mitochondrial dysfunction and age-related brain diseases.. The new findings are published in the journal Cell Reports.. Most other methods use chemical stresses on cells to simulate aging, said senior author Dr. Rusty Gage, a professor in ...
Elevated glucocorticoid levels produce hippocampal dysfunction and correlate with individual deficits in spatial learning in aged rats. Previously we related persistent cortisol increases to memory impairments in elderly humans studied over five years. Here we demonstrate that aged humans with signi …
Many detailed questions were formulated in order to provide a framework for discussing the crucial gaps in knowledge concerning CMV and immunosenescence. These included asking whether immunosenescence starts at the level of the hematopoietic stem cell (HSC); the role of the thymus? Which biomarkers are best? What impact does CMV have on the HSC microenvironment, thymus? Is there no age-associated decrease of CD8 naïve cells in CMV-negative people? Is the decrease in naïve cells in CMV+ people limited to CD8, and not CD4, cells? Is the decrease of naïve cells associated with any clinical outcome? Are T-regs altered with age and what is the effect of CMV thereon? Does CMV affect B cells (part of the IRP)? Is there a contribution of innate immunity to the IRP? What is the impact of CMV on cells bridging innate and adaptive immunity (Th17, Tγδ, NK, NKT, DC)? What is the relevance of telomere length measurements? Relevance of humoural factors, cytokines, such as type I IFN blocking telomerase; ...
Eosinophils surrounded by red blood cells (stock image). Credit: © Kateryna_Kon / stock.adobe.com Frailty and immune decline are two main features of old age.
The results of the present experiments establish that angiogenesis is impaired as a function of age. The reduced capability for collateral vessel development in response to ischemia was confirmed in 2 different animal models. The ultimate hindlimb BPR achieved at 40 days after surgery was significantly less in old than in young NZW rabbits. In old mice, perfusion of the ischemic hindlimb, reflected by the Doppler flow ratio, was significantly reduced compared with young mice; this difference was apparent as soon as 7 days after surgery and persisted throughout the duration (28 days) of the study. Likewise, the number of blood vessels that were angiographically visible in rabbits and the number of capillaries per unit area identified histologically in mice and rabbits were both significantly reduced in old versus young animals. The latter finding is consistent with the observation that myocardial angiogenesis related to left ventricular hypertrophy is attenuated in an age-dependent manner.20 The ...
Our results demonstrate that overexpression of mCAT protects mice from cardiac aging, providing direct evidence for the role of mitochondrial ROS in the aging of this vital organ. Several lines of evidence support this conclusion. In WT mice from the longevity cohort, we found age-dependent LV hypertrophy and a decline in cardiac performance (especially diastolic function), concomitant with the accumulation of oxidized mitochondrial proteins, mtDNA mutations, increased ventricular fibrosis, cardiomyocyte hypertrophy, a decline in SERCA2 protein, and activation of the calcineurin-NFAT pathway in the aged heart. These age-related alterations took place in the absence of significant cardiovascular risks such as diabetes, hypertension, or hypercholesterolemia, suggesting that these findings are primary changes of cardiac aging rather than secondary to other diseases. mCAT littermates were partially protected from all of the above age-related cardiac alterations, suggesting that these aging changes ...
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TY - JOUR. T1 - Calorie restriction initiated at middle age improved glucose tolerance without affecting age-related impairments of insulin signaling in rat skeletal muscle. AU - Park, Seongjoon. AU - Komatsu, Toshimitsu. AU - Hayashi, Hiroko. AU - Yamaza, Haruyoshi. AU - Chiba, Takuya. AU - Higami, Yoshikazu. AU - Kuramoto, Kazunao. AU - Shimokawa, Isao. PY - 2006/9. Y1 - 2006/9. N2 - Calorie restriction (CR) may affect glucose tolerance via modulation of the insulin action in skeletal muscle. The present study investigated the effect of CR initiated at middle age in rats bearing glucose intolerance, in comparison with CR at a younger age. Male F344 rats at 2.5 and 18 months (mo) of age were fed ad libitum (AL) or 30% CR diets for 4-4.5 mo, subjected to glucose tolerance testing, and then sacrificed 15 min after intraperitoneal glucose or saline injection to evaluate glucose-stimulated insulin response and subsequent activation of insulin signaling molecules. The protein abundance of ...
Skeletal muscle undergoes a progressive age-related loss in mass and function. Preservation of muscle mass depends in part on satellite cells, the resident stem cells of skeletal muscle. Reduced satellite cell function may contribute to the age-associated decrease in muscle mass. Here, we focused on characterizing the effect of age on satellite cell migration. We report that aged satellite cells migrate at less than half the speed of young cells. In addition, aged cells show abnormal membrane extension and retraction characteristics required for amoeboid-based cell migration. Aged satellite cells displayed low levels of integrin expression. By deploying a mathematical model approach to investigate mechanism of migration, we have found that young satellite cells move in a random memoryless manner, whereas old cells demonstrate superdiffusive tendencies. Most importantly, we show that nitric oxide, a key regulator of cell migration, reversed the loss in migration speed and reinstated the ...
TY - JOUR. T1 - Effect of whole-body vibration training on body composition, exercise performance and biochemical responses in middle-aged mice. AU - Lin, Ching I.. AU - Huang, Wen Ching. AU - Chen, Wen Chyuan. AU - Kan, Nai Wen. AU - Wei, Li. AU - Chiu, Yen Shuo. AU - Huang, Chi Chang. PY - 2015/9/1. Y1 - 2015/9/1. N2 - Aims Whole-body vibration (WBV) is a well-known light-resistance exercise by automatic adaptations to rapid and repeated oscillations from a vibrating platform, which is also a simple and convenient exercise for older adults. However, the potential benefits of WBV on aging-associated changes in body composition, exercise performance, and fatigue are currently unclear. The objective of the study is to investigate the beneficial effects of WBV training on body composition, exercise performance, and physical fatigue-related and biochemical responses in middle-aged mice. Methods In total, 24 male C57BL/6 mice aged 15 months old were randomly divided into 3 groups (n = 8 per group): ...
Sphingolipids have been implicated in age-related neurodegeneration. Previous studies have reported elevated ceramide levels in the brain of old rodents, but a systematic investigation of the impact of age on brain sphingolipid metabolism is still lacking. Here we quantified 17 key sphingolipid species in the hippocampus of young (3months), middle-aged (12months) and old (21months) male and female mice. Lipids were extracted and quantified by liquid chromatography/mass spectrometry; transcription of enzymes involved in sphingolipid biosynthesis was evaluated by qPCR. Age-dependent changes of multiple sphingolipid species - including ceramide (d18:1/18:0), sphingomyelin (d34:1), hexosylceramide (d18:1/16:0), ceramide (d18:1/24:0) - were found in mice of both sexes. Moreover, sex-dependent changes were seen with hexosylceramide (d18:1/18:0), ceramide (d18:1/22:0), sphingomyelin (d36:1) and sphingomyelin (d42:1). Importantly, an age-dependent accumulation of sphingolipids containing nervonic acid ...
Kubo KY, Kotachi M, Suzuki A, Iinuma M, Azuma K.. Chewing during prenatal stress prevents prenatal stress-induced suppression of neurogenesis, anxiety-like behavior and learning deficits in mouse offspring.. Int J Med Sci 15:849-58, 2018. Azuma K, Zhou Q, Kubo KY.. Morphological and molecular characterization of the senile osteoporosis in senescence-accelerated mouse prone 6 (SAMP6).. Med Mol Morphol 51:139-146, 2018. Azuma K, Toyama T, Katano M, Kajimoto K, Hayashi S, Suzuki A, Tsugane H, Iinuma M, Kubo KY.. Yokukansan ameliorates hippocampus-dependent learning impairment in senescence-accelerated mouse.. Biol Pharm Bull.41:1593-1599, 2018. Kizaki K, Uchida S, Yamashita F, Tsukamoto M, Azuma K.. Microstructure of osteophytes in medial knee osteoarthritis.. Clin Rheumatol. 37:2893-2896, 2018. Tsukamoto M, Wang KY, Tasaki T, Murata Y, Okada Y, Yamanaka Y, Nakamura E, Yamada S, Izumi H, Zhou Q, Azuma K, Sasaguri Y, Kohno K, Sakai A.. Findings as a starting point to unravel the underlying ...
1. Targonski P.V, Jacobson R.M, Poland G.A. Immunosenescence: role and measurement in influenza vaccine response among the elderly. Vaccine. 2007;25:3066-3069 2. Noreddin A.M, Haynes V. Use of pharmacodynamic principles to optimise dosage regimens for antibacterial agents in the elderly. Drugs Aging. 2007;24:275-292 3. Liang S.Y, Mackowiak P.A. Infections in the elderly. Clin Geriatr Med. 2007;23:441-456 4. Vasto S, Candore G, Balistreri C.R, Caruso M, Colonna-Romano G. et al. Inflammatory networks in ageing, age-related diseases and longevity. Mech Ageing Dev. 2007;128:83-91 5. High K.P, Prasad R, Marion C.R, Schurig G.G, Boyle S.M. et al. Outcome and immune responses after Brucella abortus infection in young adult and aged mice. Biogerontology. 2007;8:583-593 6. Htwe T.H, Mushtaq A, Robinson S.B, Rosher R.B, Khardori N. Infection in the elderly. Infect Dis Clin North Am. 2007;21:711-743 7. Hakim F.T, Gress R.E. Immunosenescence: deficits in adaptive immunity in the elderly. Tissue Antigens. ...
Food-grade diatomaceous earth possesses a number of anti-aging benefits. These anti-aging benefits include improvement in skin elasticity, softening of wrinkles and fine lines, and preventing the onset of age-related disorders, such as memory loss i.e. dementia and bone problems like osteoporosis. Lets take a look at how diatomaceous earth works to prevent the occurrence of osteoporosis in aged individuals. Role of Diatomaceous In Preventing Osteoporosis. Diatomaceous earth bloggers have said that it has a scientifically-proven role in maintaining the bone density and helping in overall bone formation. Its mostly beneficial in aged individuals who tend to go through age-related degeneration of bones. When a person ages, their total number of osteoclasts i.e. cells which are responsible for destruction of bone-cell tissues is much higher as compared to osteoblasts i.e. cells which are involved in integral bone formation because of their protein and minerals transport activity. This imbalance in ...
The molecular mechanisms by which heterogeneity, a major characteristic of stem cells, is achieved are yet unclear. We here study the expression of the membrane stem cell antigen-1 (Sca-1) in mouse bone marrow Mesenchymal Stem Cell (MSC) clones. We show that subpopulations with varying Sca-1 expression profiles regenerate the Sca-1 profile of the mother population within a few days. However, after extensive replication in vitro the expression profiles shift to lower values and the regeneration time increases. Study of the promoter of Ly6a unravels that the expression level of Sca-1 is related to the promoter occupancy by the activating histone mark H3K4me3. We demonstrate that these findings can be consistently explained by a computational model that considers positive feedback between promoter H3K4me3 modification and gene transcription. This feedback implicates bistable epigenetic states which the cells occupy with an age-dependent frequency due to persistent histone (de-)modification. Our ...
TY - JOUR. T1 - The role of estrogen in the development of age-related cognitive impairment and dementia. AU - Dumas, Julie. AU - Salerno, Jessica. AU - Newhouse, Paul. PY - 2006/4/1. Y1 - 2006/4/1. N2 - While evidence is conflicting, estrogen cannot be recommended for the treatment of dementia but may have a role in preserving cognitive functioning in older women. Estrogen may have a dementia-prevention effect after menopause based on epidemiologic studies (not primary prevention studies), but this is not an approved indication. At this point, the off-label prescribing of estrogen for cognitive decline in the absence of dementia is not a routine clinical practice and should be regarded as appropriate only within the context of a research study. Estrogen may be used in late-stage dementia to treat aggressive or sexually disinhibited behavior,45 but this would not be considered a routine use in dementia patients. Estrogen use after menopause has been linked to increased risk of venous thrombosis, ...
Introduction: Previous studies have shown significant age-related change in the first-order kernel response of the multifocal ERG (mfERG). However, they all involved use of ring averages across the retinal field. Purpose: To estimate the age-related changes in the localized response and retinal topography using point-to-point comparison. To determine the localized variability in the mfERG scalar product across age and the topography of the age-related change. Methods: MfERG recordings of 71 normal phakic subjects (ages 9-80) were analyzed with VERIS TM 4.8. The stimulus parameters were: 103 hexagons, 75 Hz frame rate, peak luminance 200 cd/m2, m= 2^14. Scalar products (for each hexagon based on ring average templates) were obtained and analyzed for age-related changes. Statistical measures (coefficient of variation (CV) and parameters of a linear regression model) were applied. Point-by-point comparison for hemifields was performed. Results: Each localized response showed a significant aging ...
TY - JOUR. T1 - Age-related effect of cells-donors of nuclei on efficiency of development of cloned rabbit embryos. AU - Lagutina, I. S.. AU - Mezina, M. N.. AU - Prokofev, M. I.. AU - Chernykh, V. Ya. AU - Galat, V. V.. PY - 2001/12/1. Y1 - 2001/12/1. N2 - We studied the capacity of nuclei of rabbit fibroblasts taken from various developmental stages for reprogramming in the cytoplasm of mature aging enucleated oocytes and development of the cloned embryos to the preimplantation stages. A negative correlation was found between the age of an animal-donor of fibroblasts and efficiency of the development of cloned embryos (rmorula-blastocyst = -0.826, rblastocyst = -0.7139). A reliably decreased capacity for reprogramming of the nuclei of donor fibroblasts was shown upon transition from prenatal development to the postnatal one, as well as a trend to a decreased capacity of nuclei for reprogramming during aging. Aging of cells in the culture, at least until the 10th passage, did not affect the ...
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Non-enzymatic protein modifications occur inevitably in all living systems. Products of such modifications accumulate during aging of cells and organisms and may contribute to their age-related functional deterioration. This review presents the formation of irreversible protein modifications such as carbonylation, nitration and chlorination, modifications by 4-hydroxynonenal, removal of modified proteins and accumulation of these protein modifications during aging of humans and model organisms, and their enhanced accumulation in age-related brain diseases.
Healthy aging has been shown to modulate the neural circuitry underlying simple declarative memory; however, the functional impact of negative stimulus valence on these changes has not been fully investigated. Using BOLD fMRI, we explored the effects
PURPOSE: Little research has analyzed mistrust and discrimination influencing receipt of health care services among Latinos, particularly those living in rural areas. The present study examined the associations between medical mistrust, perceived discrimination, and satisfaction with health care among young-adult rural Latinos. RESEARCH DESIGN: This cross-sectional study analyzed data from 387 young-adult Latinos (ages 18-25) living in rural Oregon. The Behavioral Model of Vulnerable Populations was utilized as the theoretical framework. Correlations were run to assess bivariate associations among variables included in the study. Ordered logistic regression models evaluated the associations between medical mistrust, perceived discrimination, and satisfaction with health care. RESULTS: On average, participants used health services 4 times in the past year. Almost half of the participants had health insurance (46%). The majority reported that they were moderately (32%) or very satisfied (41%) with ...
We investigated the influences of short-term and lifespan-prolonging long-term caloric restriction (LCR) on gene expression in white adipose tissue (WAT). Over 11,000 genes were examined using high-density oligonucleotide microarrays in four groups of 10- to 11-month-old male C57Bl6 mice that were either fasted for 18 h before death (F), subjected to short-term caloric restriction for 23 days (SCR), or LCR for 9 months and compared with nonfasted control (CO) mice. Only a few transcripts of F and SCR were differentially expressed compared with CO mice.
As we age and get older our immune system starts to decline in strength and isnt as vigorous as it once was. Because of this Life Extension Immune Senescence Protection Formula has been invented. This formula helps support and strengthens your immune
The first half of the module will explore age related changes in cognitive and moral development from early infancy to late adolescence. It will also consider the other major changes that occur in adolescence including social, biological, and neurological changes and how this might impact on normative development in this sensitive period. The second half will deal with health ageing in comparison to age-related disorders such as mild cognitive impairment and dementia. These issues will be considered in terms of brain anatomy and function as well as the effect on the individual and society. Current methods in ageing and developmental research will also be discussed.. ...
TY - JOUR. T1 - Comparative pharmacokinetics of three doses of percutaneous dihydrotestosterone gel in healthy elderly men - A clinical research center study. AU - Wang, C.. AU - Iranmanesh, A.. AU - Berman, N.. AU - Mcdonald, V.. AU - Steiner, B.. AU - Ziel, F.. AU - Faulkner, S. M.. AU - Dudley, R. E.. AU - Veldhuis, J. D.. AU - Swerdloff, R. S.. PY - 1998/11/10. Y1 - 1998/11/10. N2 - Twenty-five men, 60-80 yr old, participated in a pharmacokinetic study to compare three doses (16, 32, and 64 rag/day, n = 8 or 9 in each group) of 5α-dihydrotestosterone (DHT) gel (0.7% hydroalcoholic gel with 2.3 g gel delivering 16 mg DHT) applied daily over one upper arm (16 mg); both arms and shoulders (32 mg); and bilateral arms, shoulders, and upper abdomen (64 mg), respectively. Multiple blood samples for the pharmacokinetic profile for DHT and testosterone (T) were drawn over a 24-h period before application, after first application, and after 14 days of daily application of DHT gel. Additional blood ...
Researchers at Columbia University Medical Center reversed age-related memory loss in mice by boosting blood levels of osteocalcin, a hormone produced by bone cells.
Elderly men with low levels of testosterone or other sex hormones have twice the likelihood of having declining physical function over two years time compared with their peers who have the highest hormone levels, a new study from Australia finds. The results will be presented Saturday at the joint meeting of the International Society of Endocrinology and the Endocrine Society: ICE/ENDO 2014 in Chicago.
The individual and combined effects of cimetidine and ciprofloxacin on theophylline metabolism were examined in healthy young and elderly male and female nonsmokers. Single-dose studies of theophylline pharmacokinetics were performed at base line and on the fifth day of each of three treatment regimens consisting of 400 mg cimetidine every 12 hr, 500 mg ciprofloxacin every 12 hr and the combination of cimetidine and ciprofloxacin. Base-line theophylline plasma clearance and formation clearance of theophylline metabolites decreased with age in both gender groups to a similar extent (20% less in elderly men than in young men; 24% less in elderly women than in young women). Individually, cimetidine and ciprofloxacin produced proportionate declines in plasma theophylline clearance that were similar among the four groups (range, 23.4-32.7% decrease). The combined regimen yielded further impairment in theophylline elimination compared with each agent alone (range, 35.9-42.6% decrease). Cimetidine was ...
Inflammaging and immune senescence mini-review, a new area of research studying the changes in the immune system that occur as people age. Using flow cytometry, the pathological characteristics of aging tissues across multiple species can be identified.
Aging stem cells may play a critical role in determining the effects of aging on organ function. With regard to vascular diseases, it has been postulated that circulating EPCs are involved in the repair mechanisms after endothelial damage (27,28). Ultimately, deterioration of endothelial or vascular function may be related to both quantitative and qualitative changes of stem cells.. We describe here the first comprehensive analysis of the association between age-related endothelial dysfunction and the number and function of circulating EPCs, defined by expression of CD34+/VEGFR2+ and CD133+/VEGFR2+. Although no quantitative differences in EPCs were observed, our data illustrate that culture-enriched EPCs from old but otherwise healthy subjects are impaired in terms of fundamental functional features like proliferation (important for amplifying the cellular pool), migration (critical for homing of circulating EPCs), and survival. We demonstrate a significant univariate correlation between the ...
Deficiency of the fast-twitch muscle protein alpha-actinin-3 due to homozygosity for a nonsense polymorphism (R577X) in the ACTN3 gene is common in humans. alpha-Actinin-3 deficiency (XX) is associated with reduced muscle strength/power and enhanced endurance performance in elite athletes and in the general population. The association between R577X and loss in muscle mass and function (sarcopenia) has previously been investigated in a number of studies in elderly humans. The majority of studies report loss of ACTN3 genotype association with muscle traits in the elderly, however, there is some indication that the XX genotype may be associated with faster muscle function decline. To further explore these potential age-related effects and the underlying mechanisms, we examined the effect of alpha-actinin-3 deficiency in aging male and female Actn3 knockout (KO) mice (2, 6, 12, and 18 months). Our findings support previous reports of a diminished influence of ACTN3 genotype on muscle performance in the
Age-related gene response of human corneal endothelium to oxidative stress and DNA damage. Invest Ophthalmol Vis Sci. 2011 Mar 01; 52(3):1641-9 ...
ABSTRACTInsulin-like growth factor-I (IGF-I) clearly plays a role in bone metabolism and maintenance, as evidenced by in vitro and animal studies. In clinical studies, the age-related decrease in IGF-I parallels the age-related decrease in bone mineral density (BMD), but several age-adjusted cross-s
TY - JOUR. T1 - Age-related increase of airway neutrophils in older healthy nonsmoking subjects. AU - Pignatti, Patrizia. AU - Ragnoli, Beatrice. AU - Radaeli, Alessandro. AU - Moscato, Gianna. AU - Malerba, Mario. PY - 2011/8/1. Y1 - 2011/8/1. N2 - Background: Although an influence of advancing age on lung cellularity in healthy subjects has already been described, induced sputum reference values for cell counts in older healthy adults are not available. The aim of the present study was to evaluate the influence of age on the variation of sputum cell distribution in a considerable number of healthy subjects. A total of 70 nonatopic, nonsmoker healthy subjects aged ≥50 years underwent sputum induction and blood cell count. Sputum samples were processed and then were analyzed by optical microscopy. Differential cell counts were reported as percentages and amount of cells/mg. Results: Sputum cell distribution of healthy subjects aged ≥50 years was mainly composed of neutrophils. Both the ...
Immunosenescence refers to the gradual deterioration of the immune system brought on by natural age advancement. It involves both the hosts capacity to respond to infections and the development of long-term immune memory, especially by vaccination. This age-associated immune deficiency is ubiquitous and found in both long- and short-living species as a function of their age relative to life expectancy rather than chronological time. It is considered a major contributory factor to the increased frequency of morbidity and mortality among the elderly. Immunosenescence is not a random deteriorative phenomenon, rather it appears to inversely repeat an evolutionary pattern and most of the parameters affected by immunosenescence appear to be under genetic control. Immunosenescence can also be sometimes envisaged as the result of the continuous challenge of the unavoidable exposure to a variety of antigens such as viruses and bacteria. Immunosenescence is a multifactorial condition leading to many ...
The incidence of VTE is significantly lower in children compared with adults, suggesting the presence of protective mechanisms [11]. In children, the coagulation system develops with age, as evidenced by significant age-related differences in the concentration of most clotting factors, a concept known as developmental hemostasis [11].. In a nationwide epidemiologic study in the Korean population, the annual incidence of VTE in 2008 was reported as 13.8 cases per 100,000 individuals [12], which is significantly lower than the annual incidence noted for the Caucasian population (143 cases per 100,000 individuals) [13]. Furthermore, the incidence of VTE in Korean youth was even lower, with a reported 0.09 cases per 10,000 individuals aged 0-19 years [12].. In our study, the incidence of VTE was 3.27 cases per 10,000 pediatric patients. This rate was higher than the previously reported VTE incidence in the general Korean pediatric population but was lower than the incidence reported from Western ...
Alzheimers disease (Advertisement) can be an age-associated disease seen as a increased build up of extracellular -amyloid (A) plaques within the mind. a crucial developmental period at six months where cells remain in a position MK-2866 to connect to A fibrils but drop their capability to phagocytose it. and so are maintained inside a basally reactive phenotype [31C33]. Consequently, adult microglia instead of early postnatal microglia may provide a even more relevant model for determining the complete microglia-A conversation during disease. Many studies have recorded that acutely isolated adult microglia from rodent brains maintain a quiescent phenotype although long term culturing ultimately prospects to activation [23, 34C38]. To be able to better define whether an age-dependent switch in microglial A conversation is present, microglia acutely isolated from differing age group C57BL/6 mouse brains had been utilized to examine not merely degrees of putative A receptors, but moreover, ...
As PS1 is an integral protein of the γ-secretase complex, its stoichiometry may play an important role in balanced processing of APP. A decrease in PS1 (Refolo et al., 1999) or inactivation by mutations (Sudoh et al., 1998) may be associated with increased Aβ42. We had previously noticed an increase in APP as well as Aβ1-42 with age in SAMP8 mice (Morley et al., 2000), suggesting that a decrease in PS1 may cause increased aberrantγ -secretase activity. Accumulation of Aβ is attributed to loss of memory, as reduction of APP expression reverses this loss (Kumar et al., 2000). Therefore, reduction in APP expression is one of the pharmaceutical approaches to counter age-dependent or neurodegenerative disorders like AD that involve memory loss. Being an essential component of γ-secretase, PS1 is another therapeutic target for reducing Aβ formation. As SAMP8 mice have been shown to exhibit memory loss at a relatively early age (Flood and Morley, 1998; Miyamoto, 1997), we have studied the ...
As shown in Table 1, at 9 months of age, we observed a decline in GFR and renal plasma flow in the animals which ingested the lipid-rich diets, and in 18-month-old rats, the fish oil and butter groups showed a significant decrease in those parameters when compared to the control group at the same age; if corrected for kidney weight, these differences were still present; for example, GFR was 1.95 ± 0.11 in controls, 0.95 ± 0.04 in the butter group, 1.04 ± 0.17 in the fish oil group and 1.33 ± 0.29 ml min-1 g-1 in the canola oil group, confirming that the age-dependent decline in renal function was accelerated by the ingestion of LD. The complex mechanism by which lipids aggravate renal diseases is not well understood. Factors such as intraglomerular macrophage infiltration, increased glomerular capillary pressure and the degree of lipoprotein oxidation have been claimed to be major determinants of the progression of glomerulosclerosis (5-7). However, the controversy about the effects of ...
The present invention is a method for analyzing the biological age of a subject. The method analyzes the biological age as it relates to a number of factors indicating levels of health, energy production and metabolism. The method may also be used to calculate a subjects biological age and treat the factors associated with biological age.
With extension of the average lifespan, the ageing population has become a heavy burden for both society and individuals. Immune responses, key for the removal of pathogens and damage, are compromised in the elderly, making the elderly more susceptible to infections. In addition immune senescence is a risk factor for many late-onset diseases, such as cancer and atherosclerosis. Autophagy through degrading bulk cytoplasmic material maintains cytoplasmic health and cellular homeostasis [1]. We have found that it allows differentiation of immune cells [2] [3]. In previous work we showed that loss of autophagy in macrophages results in low-grade inflammation (inflamm-aging) and reduces innate and adaptive immune responses, typical of a senescent immune system. Autophagy induction rejuvenates immune responses in the elderly in T cells [3]. We have recently uncovered a novel pathway that controls the translation of autophagy proteins in T and B lymphocytes. Lymphocytes from old mice and elderly humans ...
This two-part study is assessing the pharmacokinetics and effects on age-related cognitive decline of GSK-2981710 (medium chain triglycerides) in elderly
https://doi.org/10.18632/oncotarget.6168 Po-Hsiang Liao, Dennis Jine-Yuan Hsieh, Chia-Hua Kuo, Cecilia-Hsuan Day, Chia-Yao Shen, Chao-Hung Lai, Ray-Jade Chen, V. Vijaya Padma, Wei- Wen Kuo,...
Molecular Cardiology, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MADepartment of Orthopedic Surgery, Brigham and Womens Hospital, Harvard Medical School, Boston, MA ...
Background With increasing age neuromuscular deficits (e.g., sarcopenia) may result in impaired physical performance and an increased risk for falls. Prominent intrinsic fall-risk factors are age-related decreases in balance and strength / power performance as well as cognitive decline. Additional studies are needed to develop specifically tailored exercise programs for older adults that can easily be implemented into clinical practice. Thus, the objective of the present trial is to assess the effects of a fall prevention program that was developed by an interdisciplinary expert panel on measures of balance, strength / power, body composition, cognition, psychosocial well-being, and falls self-efficacy in healthy older adults. Additionally, the time-related effects of detraining are tested.. Methods/Design Healthy old people (N = 66) between the age of 65 to 80 years will participate in this trial. The testing protocol comprises tests for the assessment of static / dynamic steady-state balance ...
What is it? The aging eye can be affected in many different ways. One of them being the formation of a cataract or clouding of the normal human crystalline lens. The other common age related change affecting the eye is called age related macular degeneration (AMD). This condition usually affects people in the 6th or 7th decade of life, but may occur in the younger population.. This condition affects the area at the back of the eye, responsible for the central part of the vision, the macula (see Eye anatomy). Degeneration, or breakdown of this part of the retina causes loss of central vision, and is one of the most common causes of legal blindness in South Africa, and the world. Most patients retain some form of peripheral vision, but overall prognosis in late / advanced AMD can be very poor.. What is DRY and WET AMD? Dry AMD is the more common form and is also referred to as atrophic or non-exudative AMD. There is formation of drusen beneath the macula that build up and eventually causes ...
The aim of this doctoral thesis was to investigate and to understand the implication of oxidative stress, created by the interplay of ionizing (X-ray) radiation, oxygen and neurotoxic amyloid beta (Aβ) peptide, in age-associated diseases, with the focus on Alzheimer´s disease (AD), the most common dementia. Although AD has been known for more than hundred years, its mechanisms are still intriguing and there is no cure at the moment. High doses of ionizing radiation (IR) lead to learning and memory impairment which is characteristic for AD as well. The cumulative doses of IR used in medical imaging procedures such as computed tomography (CT) and dental X-rays present a potential danger, particularly to children whose brains are not completely developed. Although single doses of radiation used for diagnostic purposes or therapeutic treatment are relatively low, small changes on the molecular and cellular level may accumulate upon repeated exposure and result in delayed long-term defects. Thus, ...
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Authors: Stepanichev, Mikhail , Onufriev, Mikhail , Aniol, Viktor , Freiman, Sofia , Brandstaetter, Hemma , Winter, Stefan , Lazareva, Natalia , Guekht, Alla , Gulyaeva, Natalia Article Type: Research Article Abstract: Background: Aging is associated with some cognitive decline and enhanced risk of development of neurodegenerative diseases. It is assumed that altered metabolism and functions of neurotrophin systems may underlie these age-related functional and structural modifications. CerebrolysinTM (CBL) is a neuropeptide mixture with neurotrophic effects, which is widely used for the treatment of stroke and traumatic brain injury patients. It is also evident that CBL has an overall beneficial effect and a favorable benefit-risk ratio in patients with dementia. However, the effects of CBL on cognition and brain neurotrophin system in normal aging remain obscure. Objective: The aim …of the present study was to examine the age-related modifications of endogenous neurotrophin systems in the ...
TY - CHAP. T1 - Effect of aging on changes of nociception and Cav2α1 expression patterns in seven inbred mouse strains. AU - Takahashi, Eiki. PY - 2012/8. Y1 - 2012/8. N2 - The depolarization induced by Cav2 decreases and pain threshold increases with aging. To characterize strain dependence of age-related changes in nociception and spinal expression of Cav2 in mice, we evaluated nociceptive sensitivity and Cav2α1 mRNA expression in 2-month-old and 20-month-old mice of seven inbred strains (A/J, AKR/N, BALB/c, C3H/HeJ, C57BL6/J, DBA/2, 129/SvJ). In the hot plate test, 20-month-old C3H/HeJ showed reduced thermal nociceptive thresholds relative to 2-month-old mice, but no difference was observed between 2-month-old and 20-month-old mice of other strains. In the formalin paw test, there was no difference in licking/biting time in phase 1 between 2-month-old and 20-month-old animals of any strain, but the phase 2 responses in 20-month-old C3H/HeJ and DBA/2 were decreased compared with those of ...
Analysis of mitochondrial function in tissues, such as the skeletal muscle of older subjects, reveals a decline in mitochondrial respiratory capacity to roughly 50% of what is seen in younger subjects and a reduction in ATP (63, 64). These mitochondrial deficits track closely with functional decline in muscle strength and are believed by most to be a causal factor for age-related sarcopenia (65). While, as mentioned above, in certain rare cases, accumulation of mtDNA mutations might contribute to this functional deficit, it is likely that other mechanisms are at play. An increase in the steady-state levels of dysfunction could be due to an increase in age-dependent damage to mitochondria, an age-dependent decline in the removal of dysfunctional mitochondria, or some combination of both mechanisms. The removal of damaged but intact mitochondria occurs through the process of mitophagy. We have already briefly discussed this process in the setting of inflammasome activation, where mitophagy, by ...