TY - JOUR. T1 - Age-associated Differences in Cardiovascular Inflammatory Gene Induction during Endotoxic Stress. AU - Saito, Hiroshi. AU - Papaconstantinou, John. PY - 2001/8/3. Y1 - 2001/8/3. N2 - Upon physiological stress, families of stress response genes are activated as natural defense mechanisms. Here, we show that induction of specific inflammatory genes is significantly dysregulated and altered in the heart of aged (24-26-month-old) versus young (4-month-old) mice experimentally challenged with a bacterial endotoxin, lipopolysaccharide (LPS, 1.5 mg/kg of body mass). Whereas the LPS-mediated induction of cardiac mRNA for tumor necrosis factor α or inducible nitric-oxide synthase showed no age-associated differences, the induction of interleukin-1β (IL-1β) and intracellular adhesion molecule-1 was modestly extended with aging, and the induction of IL-6 was significantly prolonged with aging. This age-associated phenomenon occurred gradually from 4 to 17 months of age and became more ...
Musculoskeletal conditions are a major burden on individuals, healthcare systems, and social care systems throughout the world, with indirect costs having the predominant economic impact. Aging is a major contributing factor to the development and progression of arthritic and musculoskeletal diseases. Indeed, aging and inflammation (often referred to as "inflammaging") are critical risk factors for the development of osteoarthritis (OA), which is one the most common forms of joint disease. The term "chondrosenescence" has recently been introduced to define the age-dependent deterioration of chondrocyte function and how it undermines cartilage function in OA. An important component of chondrosenescence is the age-related deregulation of subcellular signalling pathways in chondrocytes. This mini-review discusses the role of age-related alterations in chondrocyte signaling pathways. In this article we focus our attention on two major areas: age-dependent alterations in transforming growth factor-β ...
Investigations of intracellular signaling revealed reduced phosphorylation of AKT in MDDCs from aging, suggesting decreased activation of PI3kinase signaling pathway. Since PI3K signaling pathway plays a positive regulatory role in phagocytosis and migration, and it also functions as a negative regulator of TLR signaling by inducing activation of p38 MAP kinase, this may explain the aberrant innate immune functioning of DCs from aged subjects. Results further revealed an increased expression of PTEN, a negative regulator of PI3Kinase signaling pathway, in MDDCs from aged subjects. Increased PTEN may thus be responsible for the defect in AKT phosphorylation and therefore, altered innate immune response of DCs from aged humans.. This study is supported in part by a grant AG027512 from NIH and partly by new scholar grant from the Ellison Medical Foundation. ...
Voltage-gated sodium channels (VGSCs) generate the Na+ current (INa) responsible for the cardiac action potential upstroke largely due to the cardiac isoform Nav1.5, but other isoforms are responsible for ˜20% of the upstroke and a component of a sustained sodium current. This sustained component has been attributed with an increasing arrhythmia risk, particularly within the elderly and has been the target of development for new anti-arrhythmic drugs. Our study has investigated the age-associated changes in protein density and localisation of the VGSC alpha-subunits Nav1.5 and Nav1.4 in the rat heart.. Rats at 6, 12 and 28 months of age were sacrificed, their hearts dissected into the regions of left and right ventricle, left and right atria, epicardium and endocardium (n = 5). These regions were analysed by western blot to determine the protein expression of Nav1.5 and Nav1.4 (Alomone, Israel), normalised to the expression of desmin (Dako, UK). Immunocytochemistry of single cardiac myocytes ...
Researchers at Mayo Clinic have shown that eliminating cells that accumulate with age could prevent or delay the onset of age-related disorders and disabilities. The study, performed in mouse models, provides the first evidence ...
Greater social contact and support are associated with better cognitive functioning, whereas greater conflict is associated with lower cognitive functioning.. Diseases either caused by or associated with aging - particularly vascular changes - play a larger role in age-related cognitive changes than is often acknowledged.. This collection of articles, titled "Cognition, Health, and Aging: Integrating Perspectives Across Disciplines," is based on papers presented at a conference held at Penn State University in 2009. Funding for the supplemental issue was provided by the National Institute on Aging through the resources of the Center on Population Health and Aging at Penn State University, and the National Academies Keck Futures Initiative grant, Health and Healthspan in Longitudinal Studies of Aging.. The Journals of Gerontology Series B: Psychological Sciences and Social Sciences is a refereed publication of The Gerontological Society of America (GSA), the nations oldest and largest ...
The retinal hypoperfusion found in the present study is also in support of the cerebral hypoperfusion, which occurs during normal aging (Table 4).1,5,11,22 Chen et al.1 studied the age-related reduction of CBF during normal aging in a cohort of normal subjects and found that the CBF as an indirect measurement of brain perfusion declined at a rate of −0.38% per year when the entire cortex was examined. Meanwhile, the cortical grey matter volume decreased at a rate of −0.85% per year, which exceeds the reductions in CBF.1 Leenders et al.5 reported that the CBF, cerebral blood volume, and cerebral metabolic rates of oxygen decline at a rate of −0.5% per year during normal aging. The changing rate of the RTP (−0.47% per year), RBF (−0.41% per year), and VVDd (−0.44% per year) found in the present study well matches the CBF change rates reported by Chen et al.1 and Leenders et al.,5 indicating that the RTP, RBF, and VVDd may be good candidates for imaging markers of the age-related ...
Huber, N., Sakai, N., Eismann, T., Shin, T., Kuboki, S., Blanchard, J., Schuster, R., Edwards, M. J., Wong, H. R. and Lentsch, A. B. (2009), Age-related decrease in proteasome expression contributes to defective nuclear factor-κB activation during hepatic ischemia/reperfusion. Hepatology, 49: 1718-1728. doi: 10.1002/hep.22840 ...
Age-related alterations in brain structure and function have been challenging to link to cognition due to potential overlapping influences of multiple neurobiological cascades. We examined multiple brain markers associated with age-related variation in cognition. Clinically normal older humans aged 65-90 from the Harvard Aging Brain Study (N = 186) were characterized on a priori magnetic resonance imaging markers of gray matter thickness and volume, white matter hyperintensities, fractional anisotropy (FA), resting-state functional connectivity, positron emission tomography markers of glucose metabolism and amyloid burden, and cognitive factors of processing speed, executive function, and episodic memory. Partial correlation and mediation analyses estimated age-related variance in cognition shared with individual brain markers and unique to each marker. The largest relationships linked FA and striatum volume to processing speed and executive function, and hippocampal volume to episodic memory. ...
In the past two decades neuroimaging studies have tried to unveil the neural mechanisms behind age-related changes in cognitive strategies and performance. Structural imaging studies have shown that brain volume changes throughout the complete life-span and functional imaging studies have reported age-related differences in brain activation and connectivity. ... read more The aim of this thesis was to provide an overview of studies that report age-related changes in brain activation as measured with functional MRI in a longitudinal design in healthy subjects. We found 16 studies of which 11 reported changes in activity over time. The majority of studies was performed in children. fMRI task used varied between attention, language, memory, working memory and sensory processing tasks. We found increases and decreases in activation in children between 5 and 20 and adults above age 50. A trend of left-hemispheric increases were shown for children around age 8, adults around age 66 and in language ...
Age is the single greatest risk factor in the development of the blinding eye disease AMD where the prevalence of disease significantly increases as individuals enter their sixth decade. 2,3 In spite of this universal observation, other factors that lead to increased disease incidence remain undefined. Increases in damage from environmental stresses, accumulation of damaged proteins and organelles, and loss of function in important biochemical pathways all have been proposed. 3,4,13,52 The immune system is also thought to have a role in disease development 12-14,53 ; however, few studies have addressed how age-related changes in the immune response could be involved. The eye also is an immune privileged organ that can have a strong inhibitory influence on inflammatory and neovascular responses via a number of immunosuppressive mediators. 21 How age-dependent changes in the immune system are influenced by immune privilege and how age might alter the function of immune privilege is currently ...
Immune aging may underlie various aging-related disorders, including diminished resistance to infection, chronic inflammatory disorders, and autoimmunity. PD-1+ and CD153+ CD44high CD4+ T cells with features of cellular senescence, termed senescence-associated T (SA-T) cells, increasingly accumulate with age and may play a role in the immune aging phenotype. In this article, we demonstrate that, compared with young mice, the aged mouse environment is highly permissive for spontaneous proliferation of transferred naive CD4+ T cells, and it drives their transition to PD-1+ and CD153+ CD44high CD4+ T cells after extensive cell divisions. CD4+ T cells with essentially the same features as SA-T cells in aged mice are also generated from naive CD4+ T cells after extensive cell divisions under severe T-lymphopenic conditions by gamma irradiation or in developmental T cell defect, often in association with spontaneous germinal centers, as seen in aged mice. The increase in SA-T cells is significantly enhanced
Geoffroy CG, Hilton BJ, Tetzlaff W, Zheng B How aging impacts axon regeneration after CNS injury is not known. We assessed the impact of age on axon regene …
TY - JOUR. T1 - Analysis of the age-related refractoriness of T-lymphocyte reactivity in humans. AU - Bátory, Gabriella. AU - Ónody, Clara. AU - Petrányi, G. Gy. PY - 1981/4. Y1 - 1981/4. N2 - Aged individuals could be divided into two groups according to their T-lymphocyte transformation values. The relationship between the PHA (phytohemagglutinin) stimulation indices and spontaneous thymidine incorporation; the PHA dose-response type distribution and the relative number of resting T lymphocytes was similar to the control group in aged subjects of seemingly intact T lymphocyte transformation values. However, their B cell compartment was found to be reduced. On the other hand, the ratio between the stimulation indices and spontaneous thymidine incorporation values of aged subjects of impaired T lymphocyte reactivity deviated from that of the control group. This group had an increased frequency of subjects giving maximal transformation values at relatively high PHA doses (hyposensitives) at ...
Umbilical cord blood from human newborns, and in particular a single protein contained in it, boosted old mices brain function and cognitive performance
The present study tested whether aging alters endotoxin-induced myocardial dysfunction in a sublethal model of endotoxemia in rats. The main findings were the following: 12 hours after LPS injection (0.5 mg/kg), a marked reduction in myocardial contractility was observed in the isolated perfused senescent heart; in contrast with septic cardiac dysfunction in young rats, myofilament Ca2+ sensitivity of left ventricular skinned fibers was not reduced in senescent rats; and NO production, oxidative stress, and antioxidant enzymes activities were not different between young adult and senescent LPS groups. Thus, despite similar alterations in potential mediators, cellular mechanisms responsible for this contractile dysfunction are different between young adult and senescent rats. More specifically, myofilament Ca2+ responsiveness remains unaltered in the senescent heart. This may have clinical implications for management of elderly septic patients.. Nonlethal models of endotoxemia have allowed ...
We use cookies to ensure that we give you the best experience on our website. If you click Continue well assume that you are happy to receive all cookies and you wont see this message again. Click Find out more for information on how to change your cookie settings ...
First, we found that the level of soluble HS is positively correlated with age in vitreous samples from idiopathic maculopathies. We then showed that soluble HS levels in aqueous humor were lower in younger diabetic subjects with retinal NVs than in older diabetic subjects without retinal NVs or in nondiabetic subjects with cataract; the difference was no longer significant after controlling for the ages in these groups. The lack of correlation between severity of retinopathy and HS levels suggests that reduced HS levels in the aqueous humor in younger PDR patients could be explained at least in part by age and not by the severity of retinopathy. While the observation appears to contradict the reported correlation between reduced HS levels in the kidney and the diabetes mellitus [16-18], our study does not exclude the possibility of a less significant contribution of diabetes mellitus to ocular levels of HS. Analysis of the intraocular fluid from nondiabetic controls age-matched for PDR and a ...
Various age-related changes in the biomechanics and topography of different ocular components have been reported in the literature. Albon et al. (2000) observed a decrease in both the mechanical compliance and resilience of the human lamina cribrosa with age, and similar observations were made by Krag et al. (1997) in the lens capsule. Strong association was found between the age-related alterations in the optic nerve head and its increased susceptibility to glaucomatous damage (Burgoyne & Downs 2008). The asphericity of both the anterior and posterior corneal surfaces was reported to undergo significant changes with age, leading to a more spherical topography (Lam & Douthwaite 2002) and peripheral thinning (Dubbelman et al. 2006). Stiffening and increased tensile strength of the sclera were also found to be strongly associated with age (Avetisov et al. 1983; Schultz et al. 2008). Where an explanation was provided for these changes, it was the age-related increase in the intermolecular and ...
Evidence for age-dependent impairment of ovalbumin heterogeneous nuclear RNA (HnRNA) processing in hen oviduct.: The expression of the ovalbumin gene in hen ovi
This data collection contains data gathered in a longitudinal study of a sample of men aged 65 to 92 who were in good health during the first wave of the study in 1957. The chief aim of the study was to focus on the nature of the normal aging process in individuals of advanced age. The 47 study participants had not suffered from accidents, illnesses, severe emotional or personality problems, or environmental difficulties that might have led to premature aging, but 20 participants showed evidence of asymptomatic subclinical disease. This group represented the typical or average healthy aged individual with minimal degrees of physical pathology. Five years later, in 1962, a follow-up study was conducted with 29 of the 39 men still alive. The second follow-up, done in 1968, involved 19 of the surviving 23 men. The data are arranged in files by year: 1957, 1962, and 1968. Included are psychiatric data and medical evaluative data as well as various psychological and medical test scores (e.g., ...
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
The effects of the co-agonist of the N-methyl-d-aspartate receptor (NMDAr) d-serine on glutamatergic neurotransmission and synaptic potentiation were studied in the CA1 hippocampal field of young (3-5 months old) and aged (25-27 months old) Sprague-Dawley rats using ex vivo extracellular electrophysiological recording techniques. Exogenous d-serine depressed fast neurotransmission mediated by the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid/kainate subtype of glutamate receptors in young but not in aged rats by acting on inhibitory glycinergic interneurons. In contrast, d-serine dose-dependently enhanced NMDAr-mediated synaptic responses in both groups of animals, but with a larger magnitude in aged rats, thus preventing the age-related decrease in NMDAr activation. d-serine also increased the magnitude of long-term potentiation in aged but not in young rats. Finally, d-serine levels were dramatically reduced in hippocampal tissues of aged rats. Taken together, these results indicate a ...
Background: Acute lung injury (ALI) is a significant source of morbidity and mortality in critically ill patients. Age is a major determinant of clinical outcome in ALI. The increased ALI-associated mortality in the older population suggests that there are age-dependent alterations in the responses to pulmonary challenge. The objective of this observational study was to evaluate age-dependent differences in the acute (within 6 hours) immunological and physiological responses of the heart and lung, to pulmonary challenge, that could result in increased severity. Methods: Male C57Bl/6 mice (young: 2-3 months, old: 18-20 months) were challenged intratracheally with cell wall components from Gram-positive bacteria (lipoteichoic acid and peptidoglycan). After 6 hours, both biochemical and physiological consequences of the challenge were assessed. Alveolar infiltration of inflammatory cells and protein, airspace and blood cytokines, cardiac function and myocardial proteasome activity were determined. Results:
... Mechanisms of Ageing, with Institute of Molecular Biology gGmbH (IMB). Apply Today.
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Chair: Juulia Jylhävä. Markers of biological age have recently proven to be strong mortality predictors independent of other risk factors. As individuals with the same chronological age can vary substantially for their biological age it has become a pressing issue to find the determinants for biological age. This symposium presents findings on the genetic and environmental influences to the following markers of biological age: self-rated health, the frailty index, the epigenetic clock and telomere length. Using unique longitudinal twin cohorts with wide age ranges, we are also able to assess the changes in the contributing sources variation - i.e., genetics and shared and unique environments. The first paper demonstrates how the heritability of self-rated health is influenced by financial strain. The second paper examines if the polygenic risk scores for well-being are predictive of objective (i.e. frailty and multi-morbidity) and subjective indicators of age-related health (e.g. ...
Recent statistics indicate that the human population is ageing rapidly. Healthy, but also diseased, elderly people are increasing. This trend is particularly evident in Western countries, where healthier living conditions and better cures are available. To understand the process leading to age-associated alterations is, therefore, of the highest relevance for the development of new treatments for age-associated diseases, such as cancer, diabetes, Alzheimer and cardiovascular accidents. Mechanistically, it is well accepted that the accumulation of intracellular damage determined by reactive oxygen species (ROS) might orchestrate the progressive loss of control over biological homeostasis and the functional impairment typical of aged tissues. Here, we review how epigenetics takes part in the control of stress stimuli and the mechanisms of ageing physiology and physiopathology. Alteration of epigenetic enzyme activity, histone modifications and DNA-methylation is, in fact, typically associated with the
Recent statistics indicate that the human population is ageing rapidly. Healthy, but also diseased, elderly people are increasing. This trend is particularly evident in Western countries, where healthier living conditions and better cures are available. To understand the process leading to age-associated alterations is, therefore, of the highest relevance for the development of new treatments for age-associated diseases, such as cancer, diabetes, Alzheimer and cardiovascular accidents. Mechanistically, it is well accepted that the accumulation of intracellular damage determined by reactive oxygen species (ROS) might orchestrate the progressive loss of control over biological homeostasis and the functional impairment typical of aged tissues. Here, we review how epigenetics takes part in the control of stress stimuli and the mechanisms of ageing physiology and physiopathology. Alteration of epigenetic enzyme activity, histone modifications and DNA-methylation is, in fact, typically associated with the
Aged rats (22 to 24 months) and young control rats (3 months) were tested in a battery of behavioral tests which included tests of learning, place navigation, sensorimotor integration, motor coordination, activity, and exploration. Following testing all animals were analyzed in an unanesthetized state for their local glucose utilization. Significant differences in glucose utilization were found between the aged and young groups on some behaviors and in some brain regions. There was considerable variability in the aged group in both their behavioral performance and their glucose utilization scores; thus, attempts were made to determine whether the variability in the degree of impairment within any particular behavioral test was correlated to the regional glucose utilization scores in any of the 45 brain regions analyzed. In two of the behavioral tests employed (i.e., one for learning and one for place navigation), the decline in performance correlated significantly with the decrement in regional ...
Matsuzawa, T and Cinader, B, "Polymorphism of age-dependent changes in the production of a thf helper factor." (1982). Subject Strain Bibliography 1982. 2609 ...
Age-dependent changes in the exocytotic efficacy in Kir6.2 ablated mouse pancreatic β-cells. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
Reduced volume, or atrophy, in parts of the brain known as the amygdala and hippocampus may predict which cognitively healthy elderly people will develop dementia over a six-year period, according to a study.
Many detailed questions were formulated in order to provide a framework for discussing the crucial gaps in knowledge concerning CMV and immunosenescence. These included asking whether immunosenescence starts at the level of the hematopoietic stem cell (HSC); the role of the thymus? Which biomarkers are best? What impact does CMV have on the HSC microenvironment, thymus? Is there no age-associated decrease of CD8 naïve cells in CMV-negative people? Is the decrease in naïve cells in CMV+ people limited to CD8, and not CD4, cells? Is the decrease of naïve cells associated with any clinical outcome? Are T-regs altered with age and what is the effect of CMV thereon? Does CMV affect B cells (part of the IRP)? Is there a contribution of innate immunity to the IRP? What is the impact of CMV on cells bridging innate and adaptive immunity (Th17, Tγδ, NK, NKT, DC)? What is the relevance of telomere length measurements? Relevance of humoural factors, cytokines, such as type I IFN blocking telomerase; ...
The results of the present experiments establish that angiogenesis is impaired as a function of age. The reduced capability for collateral vessel development in response to ischemia was confirmed in 2 different animal models. The ultimate hindlimb BPR achieved at 40 days after surgery was significantly less in old than in young NZW rabbits. In old mice, perfusion of the ischemic hindlimb, reflected by the Doppler flow ratio, was significantly reduced compared with young mice; this difference was apparent as soon as 7 days after surgery and persisted throughout the duration (28 days) of the study. Likewise, the number of blood vessels that were angiographically visible in rabbits and the number of capillaries per unit area identified histologically in mice and rabbits were both significantly reduced in old versus young animals. The latter finding is consistent with the observation that myocardial angiogenesis related to left ventricular hypertrophy is attenuated in an age-dependent manner.20 The ...
Our results demonstrate that overexpression of mCAT protects mice from cardiac aging, providing direct evidence for the role of mitochondrial ROS in the aging of this vital organ. Several lines of evidence support this conclusion. In WT mice from the longevity cohort, we found age-dependent LV hypertrophy and a decline in cardiac performance (especially diastolic function), concomitant with the accumulation of oxidized mitochondrial proteins, mtDNA mutations, increased ventricular fibrosis, cardiomyocyte hypertrophy, a decline in SERCA2 protein, and activation of the calcineurin-NFAT pathway in the aged heart. These age-related alterations took place in the absence of significant cardiovascular risks such as diabetes, hypertension, or hypercholesterolemia, suggesting that these findings are primary changes of cardiac aging rather than secondary to other diseases. mCAT littermates were partially protected from all of the above age-related cardiac alterations, suggesting that these aging changes ...
From In Search of Enlightenment: "On this WHO website the fact that chronic disease killed 9 million people under the age of 60 last year is highlighted. This is of course a human tragedy that should be mitigated. That is twice the number of deaths estimated to be caused by all injuries in the world. However, if you do the math on this data, that means that 27 million people worldwide died from chronic disease that is caused (primarily, though the story is complex) by aging. This is 75% of the worlds chronic disease burden. Aging is the leading cause of disease and death in the world today. ... Not only that, it is the largest health threat today. In just a decade of the chronic diseases of aging the worlds population will suffer more more disease and death than in any decade of the worst wars and conflicts in human history. Everyone agrees that conflict and war is bad for us, and that our governments should strive to ensure there is lasting peace between nations. And yet few people today ...
Show moreOBJECTIVE: With aging, skin is likely to become less hydrated, thereby increasing its resistance to electrical current. This, rather than sensorial/perceptual differences per se, may be the primary cause of differences between younger and older adults in somatosensorial perception in response to electrical stimuli. METHODS: To assess whether aging alters the perception of electrical stimulation, we compared the perceived intensity of electrical stimuli in younger and older subjects, considering both setpoint intensities and the actual intensities of the current passing through subjects skin. This resulted in reliable information about electrical somatosensory perception in both groups at equivalent received amounts of current. Somatosensory evoked potentials (SEPs) enabled the objective evaluation of somatosensitivity in both groups. RESULTS: At equivalent received intensities, the mean ratings were significantly lower in older than in younger subjects. SEPs confirmed these results, ...
Physical activity (PA) is known to improve health and decrease the risk of developing cardiovascular disease (CVD) in a variety of populations. However, less is known regarding the influence of habitual or daily PA in preventing cardiovascular events among older adults. In particular, data are lacking regarding the influence of daily PA on cardiovascular risk among older adults with mobility limitations that restrict the ability to engage in PA. Although associations between the quantity of PA and cardiovascular risk factors have been reported in older adults, few have made these connections using objective measurements of PA. To date, most studies have relied on self-reported measures of PA, which commonly misclassify the volume and/or intensity of PA. Although PA has been shown to have an inverse relationship with cardiovascular risk factors and morbidity, it is unknown whether participation in activity reduces cardiovascular incidence in populations of older adults displaying habitually low ...
Two groups of investigators in Canada, from the University of British Columbia, Vancouver and the University of Victoria, recently published the results of their study on the age-associated decline in memory in the journal PLoS ONE. The article, "Glutathione Restores the Mechanism of Synaptic Plasticity in Aged Mice to That of the Adult," details the teams research and conclusions on the connection between maintaining memory and a healthy redox balance in brain cells.. Previous research associated a reduced redox potential (a more oxidized cellular environment) with aging and demonstrated a correlation, in the hippocampus (specifically the CA1 region), to a lower level of the major antioxidant, glutathione (GSH). The British Columbian investigators hypothesized not only that age-associated memory impairment is a consequence of this condition, but also that GSH is key to one of two related hippocampal mechanisms.. The two mechanisms are involved in calcium ion transport and necessary for memory ...
University of Arizona Aging is associated with specific impairments of learning and memory, some of which are similar to those caused by damage to temporal or frontal lobe structures. For example, healthy older humans, monkeys and rats all show poorer spatial, recognition and working memory, than do their younger counterparts. Rats and monkeys do not develop age-related pathology such as Alzheimers or Parkinsons diseases, which makes them good models for assessing functional alterations associated with normal aging in humans. While many cellular properties of medial temporal lobe cells appear to be intact in aging animals, age-related impairments in synaptic function, plasticity and gene expression have been observed. Because information is represented by activity patterns across large populations of neurons, an understanding of the neural basis of cognitive changes in aging requires the examination of the dynamics of behaviorally-driven neural networks. Ensemble recording experiments are ...
The relationship between mental exercise and mental aging is a controversial issue. People generally believe the so-called mental-exercise hypothesis, that is, the age-related decline in cognitive fun
http://www.buckinstitute.org/garrisonlab. I started my independent research group at the Buck Institute for Research on Aging in September 2013. My lab is focused on elucidating the mechanisms by which neuromodulation by neuopeptides encodes longterm changes in the brain that influence behavior and aging. Despite strong evidence showing essential functional roles for neuropeptides in both behavior and basic physiology, at the cellular level a number of questions remain. We are exploring the role of extrasynaptic neuropeptide release in behavior, and developing strategies to interrogate the spatial and temporal specificity of neuropeptide signaling using C. elegans as a whole animal model. We are particularly interested in understanding how age related changes in neuropeptide levels in specific neurons can influence whole organism longevity. Our goal is to identify general principles by which neuropeptides modify neural circuits in a simple organism, and thus illuminate neuromodulation in more ...
Caroline has 298 books on her young-adult shelf: Tempests and Slaughter by Tamora Pierce, Before the Devil Breaks You by Libba Bray, Akata Witch by Nnedi...
In advanced age, decreased CD8+ cytotoxic T-lymphocyte (CTL) responses to novel pathogens and cancer is paralleled by a decline in the number and function of naïve CTL precursors (CTLp). Although the age-related fall in CD8+ T-cell numbers is well established, neither the underlying mechanisms nor the extent of variation for different epitope specificities have been defined. Furthermore, naïve CD8+ T cells expressing high levels of CD44 accumulate with age, but it is unknown whether this accumulation reflects their preferential survival or an age-dependent driver of CD8+ T-cell proliferation. Here, we track the number and phenotype of four influenza A virus (IAV)-specific CTLp populations in naïve C57BL/6 (B6) mice during aging, and compare T-cell receptor (TCR) clonal diversity for the CD44hi and CD44lo subsets of one such population. We show differential onset of decline for several IAV-specific CD8+ T-cell populations with advanced age that parallel age-associated changes in the B6 ...
My diagnosis with Parkinsons Disease in September 2009 at age 80 gave my life a new focus and challenge. Finding ways to meet this challenge helped make 2010 the best year of my life. I hope this blog will be a place where I can connect with others who also are dealing with aging and its afflictions and attractions so that we can share our "experience, strength and hope.". ...
Objective: Rating scales and neuropsychological tests including continuous performance tests (CPTs) are widely used to assess executive functions (EFs). Event-related potentials (ERPs) are also used to index certain EFs such as action preparation and inhibition. In this descriptive study, we examined the associations between results on an EF rating scale, a CPT and ERP components in ADHD as a function of age. Methods: Fifty-nine patients with ADHD (and more often than not with comorbid disorders) in two age groups (9-12 years and 13-17 years) were assessed using EF ratings, a visual CPT and ERPs (CueP3, P3go and P3no-go). Results: There were age related changes in the ERPs with the CueP3 amplitude being stronger in children, and the P3no-go amplitude stronger in adolescents. The associations between the EF measures were different in the two age groups. In particular, the P3no-go seemed to reflect different EF-related processes in children versus adolescents. Conclusion: Age group effects were ...
Hills® Science Diet® Active Longevity Mature Adult Dog Food - Chicken Meal, Rice & Barley at PetSmart. Shop all dog dry food online
Hills Science Diet Mature Adult Active Longevity Original supports senior dogs health with L-carnitine, Omega-3s, glucosamine, chondroitin, and more.
Ronnlund and Nilsson (2006) studied performance on the WAIS block design test in a large sample of adults both longitudinally and cross-sectionally. The time difference was about 5 years. They wanted to tease out age related changes from practice effects. I believe they estimated the 5-year practice related improvement to be about 0.6 of a T score (i.e., about .06 of a standard deviation).. Benefits of practice presumably decay as a monotonically decreasing function of time between practice and retest. Thus, presumably, any practice effects would be a fair bit greater at two months than they would be at five years.. Dikmen et al (1999) performed a study involving 384 adult participants who completed several test including the WAIS Block Design on two occasions separated by between two and twelve months. Specifically see Table 2 that reports time 1 and time 2 results:. ...
Science Plan Canine Mature Adult 7+Active Longevity Mini is specially formulated to sustain mobility and healthy vital organs in dogs seven years and...
Aging is the single most important prognostic factor associated with the development of many diseases including cancer (1). The results described here demonstrate that aging-associated increases in inflammation negatively impact the development and function of B progenitor cells, including reductions in key indicators of cell fitness. Importantly, using two different, naturally occurring molecules to reduce inflammation in old mice, we show that preventing aging-associated reductions in B progenitor fitness abrogates selection for NRASV12-initiated progenitors. These studies highlight how inflammation-induced alterations in the adaptive landscape in old age govern the selection of oncogenically initiated cells and, ultimately, leukemogenesis within hematopoietic progenitor cell populations (Figure 8D).. In recent years, there has been growing interest in identifying factors that regulate the aging process (8, 52, 53). We observed aging-associated increases in TNF-α, IL-6, and IL-1β levels in ...
Young, healthy muscle (left column) appears pink and red. In contrast, the old muscle is marked by scarring and inflammation, as evidenced by the yellow and blue areas. This difference between old and young tissue occurs both in the muscles normal state and after two weeks of immobilization in a cast. Exercise after cast removal did not significantly improve old muscle regeneration; scarring and inflammation persisted, or worsened in many cases.
Human brain ageing is characterised by decreasing cognitive function of various severity affecting 60% of aged population. Decline in cognitive capabilities might be the only symptom of ageing in otherwise healthy humans. Even more important is ageing-related development of neurodegenerative diseases, which present a significant burden to society and the health care system. Diminished cognitive function with increased age is likely a manifestation of dysregulated synaptic function and ineffective neurotransmission. We recently reported a comparative analysis of the synaptosome transcriptome in ageing mouse brain. Our results revealed changes in expression of genes contributing to biological pathways related to neurite guidance and synaptosomal physiology (Fig. 2) as well as perturbation of long non-coding RNAs (lncRNAs). The aim of this project is to explore mechanisms which lead to reshaping of the non-coding transcriptome as a result of brain ageing. The project will employ meta-analytical and ...
By studying a particularly short-lived fish species researchers have ...The development of drugs able to retard the onset of aging-related dis...Resveratrol is an organic compound naturally present in grapes--and pa...Recently a small fish species with a captive lifespan of only three m...Resveratrol appears to be the first molecul...,Resveratrol,prolongs,lifespan,and,delays,onset,of,aging-related,traits,in,a,short-lived,vertebrate,biological,biology news articles,biology news today,latest biology news,current biology news,biology newsletters
Four images, two girls - and a story. Its all in the mind; think about it. It was a hot day, the grass was very dry and they were both very thirsty, but Joanne and her small group had walked the pair all the way over to where the big, old, wooden... ...
What about a way to make cells change depending on how old they are? This could be useful to ensure certain cells dont do anything and waste energy until they mature enough to split ...
Brain aging is characterized by global changes which are thought to underlie age-related cognitive decline. These include variations in brain activity and the progressive increase in the concentration of soluble amyloid-β (Aβ) oligomers, directly impairing synaptic function and plasticity even in the absence of any neurodegenerative disorder. Considering the high social impact of the decline in brain performance associated to aging, there is an urgent need to better understand how it can be prevented or contrasted. Lifestyle components, such as social interaction, motor exercise and cognitive activity, are thought to modulate brain physiology and its susceptibility to age-related pathologies. However, the precise functional and molecular factors that respond to environmental stimuli and might mediate their protective action again pathological aging still need to be clearly identified. To address this issue, we exploited environmental enrichment (EE), a reliable model for studying the effect of
Methods From January 2011 to January 2013, totally 112 elderly patients with AMI, 67 males and 45 females, age 60 to 86 (mean 65.6 ± 5.8), were selected as AMI group. 113 cases of healthy elderly people were selected as control group. IL18 and hs-CRP were detected in fasting venous blood in the early morning from healthy elderly people or on the next day morning after admission from AMI patients.. ...
Aging is an ill-defined process that increases the risk of morbidity and mortality. Aging is also heterogeneous meaning that biological and chronological age can differ. Here, we used unbiased differential mass spectrometry to quantify thousands of proteins in mouse liver and select those that that consistently change in expression as mice age. A panel of 14 proteins from inbred C57BL/6 mice was used to equate chronological and biological age in this reference population, against which other mice could be compared. This
Click here for lab homepage:Dr. Roberson is a neurologist and neuroscientist whose research is focused on age-related cognitive impairment. He...
OBJECTIVES: To use the Medicare Files of Service Use (MFSU) to evaluate patterns in the incidence of aging-related diseases in the U.S. elderly population. DESIGN: Age-specific incidence rates of 19 aging-related diseases ...
OBJECTIVES: To use the Medicare Files of Service Use (MFSU) to evaluate patterns in the incidence of aging-related diseases in the U.S. elderly population. DESIGN: Age-specific incidence rates of 19 aging-related diseases ...
The American Aging Association is a group of experts dedicated to understanding the basic mechanisms of aging to enable methods of preserving and restoring function lost to age-related degeneration in order to extend the healthy human lifespan. Become a member here.. ...
본 연구는 연령이 증가함에 따라 나타나는 지방대사의 변화에 대하여 식이내 단백질수준이 어떻게 영향을 미치는가를 관찰하고저 행하여졌다. 실험동물은 평균체중이 70.4±2.4g (생후 4주)과 287.1±6.3g(생후 5~6개월)인 Wistar종 수컷 흰쥐 48마리를 연령에 따라 어린군(Young Group)과 성숙한 군(Adult Group)으로 나누었고 각 연령군을 7%, 15%, 50%로 단백질 수준을 각각 달리하여 5주간 사육하였다. 본 실험의 결과들을 요약해 보면 다음과 같다. 체중 100g당 식이 섭취량과 단백질 효율은 연령의 차이없이 7% 단백질군이 50%단백질군에 비해 유의적으로 높았고 체중 증가량은 두 연령군 모두 50% 단백질군에서 가장 높았다. 지방의 흡수율은 성숙한 쥐가 어린쥐보다 약간 낮았고, 단백질수준이 증가할수록 각 연령군 모두에서 낮아졌다. 혈청내 총지방량, 총콜레스테롤 및 ...
The normal age variation in left ventricular parameters in males (left) and females (right). Solid lines represent rational polynomial curve fit and dashed line
Muenchhoff J; Song F; Poljak A; Crawford JD; Mather KA; Kochan NA; Yang Z; Trollor JN; Reppermund S; Maston K, 2017, Plasma apolipoproteins and physical and cognitive health in very old individuals, Neurobiology of Aging, vol. 55, pp. 49 - 60, http://dx.doi.org/10.1016/j.neurobiolaging.2017.02.017. Tsang RSM; Mather KA; Sachdev PS; Reppermund S, 2017, Systematic review and meta-analysis of genetic studies of late-life depression, Neuroscience and Biobehavioral Reviews, vol. 75, pp. 129 - 139, http://dx.doi.org/10.1016/j.neubiorev.2017.01.028. Hibar DP; Adams HHH; Jahanshad N; Chauhan G; Stein JL; Hofer E; Renteria ME; Bis JC; Arias-Vasquez A; Ikram MK, 2017, Novel genetic loci associated with hippocampal volume, Nature Communications, vol. 8, http://dx.doi.org/10.1038/ncomms13624. Lipnicki DM; Crawford J; Kochan NA; Trollor JN; Draper B; Reppermund S; Maston K; Mather KA; Brodaty H; Sachdev PS, 2017, Risk Factors for Mild Cognitive Impairment, Dementia and Mortality: The Sydney Memory and ...
Medical supplies for the elderly are especially helpful for allowing aged individuals to perform satisfactorily in the bathroom - including shower, tub, and toilet.
People age in different ways. Biological age is a metric that scientists use to predict health risks, the relevance of which can be enhanced by combining different markers. Particularly important markers are frailty and the epigenetic clock, write researchers from Karolinska Institutet in a study published in eLife.
brain areas. Acetylcholine also seems to play a crucial role The incidence of POD varies between 5.1% and 52.5% in the development of POD due to its various roles in the in elderly patients undergoing major surgery, and certain regulation of cerebral functions, including motor activity, procedures such as hip fracture or aortic surgery having higher rapid eye movement (REM) sleep, mood, attention, and risk of POD4,5,7,8,21,22,27). Because there has been practically memory. Thus, the lack of acetylcholine or relative excess no neurosurgical literature on the incidence of POD, we of dopaminergic transmission seems to be connected to could not compare the 21.4% incidence in our study with the development of POD. The age-dependent decrease of that from similar studies. We could only assume that the acetylcholine transmission is a physiologic process, and incidence was not much higher than expected. Several reduced "cholinergic reserve" may be responsible for the contributing factors such as ...
GenDR A curated database of genes associated with dietary restriction in model organisms either from genetic manipulation experiments or gene expression profiling.. ...
GenDR A curated database of genes associated with dietary restriction in model organisms either from genetic manipulation experiments or gene expression profiling.. ...
Big biology news today: three teams of scientists (from UNC, Michigan and Hahvahd) jointly published work that hints at the incredibly complex balance of cell proliferation, aging and cancer. The groups each worked with a particular tumor suppressor, p16INK4a, in different tissues. The genes expression gradually increases with age, and its increased expression seems not only to prevent age-related out-of-control cell growth (cancer=bad), but also prevents stem-cell proliferation (stem cells=good). Its a fascinating and tricky balance. Tumor suppression is increasingly important as we age, but the flip side of that is a loss of the stem cells that are so important for renewing our tissues. I supposed the debate turns to whether wed rather get cancer or have garden-variety age-related degeneration. From the linked NYT article, one of the lead scientists summed it up optimistically ...
Mitochondrial dysfunction frequently occurs in aged individuals and is a hallmark of diseases such as Parkinsons, Alzheimers, cancer, and diabetes. Organisms...
ContextAlthough depression is associated with increased cardiovascular morbidity and mortality, there is virtually no information on whether it also increases t
Eggs are also a rich source of antioxidants like lutein and zeaxanthin, which improve the health of the retina and prevent macular degeneration and age-related disorders related to the eyes
Global Oral X-Ray Machines Market is driven by rising number of aged individuals suffering from periodontal diseases. Market for Oral X-Ray Machines is dominated by North America .
Our mission is to facilitate research that helps understand, predict and prevent age-related degeneration. We have a specific focus on the eye, the mind, the metabolism and medicines and devices in the context of the psychological, social and policy factors affecting ageing lives. ...
Dye extends lifespan in nematodes and slows Alzheimers like disease in worms. What does this mean for treatment of age-related diseases?
Today acne is one of the most typical skin complaints that both young and old individuals will have to deal with at some point in their lives. Unfortunatel
Confocal images of coronal subventricular zone (SVZ) sections showing that 22-month-old mice injected with rGDF11 for 4 weeks have (A) enhanced vascularization
Free Essays from 123 Help Me | covering the nervous system. Some processes I will cover will be brain function in relation to nerves, and how age changes...
A new study on UHT milk is helping scientists to better understand Alzheimers, Parkinsons and type 2 diabetes, opening the door to improved treatments for these age-related diseases.
The heart holds its own pool of immune cells capable of helping it to heal after injury, finds research, adding that the harmful immune cells from the bone marrow disrupts this process in adults.
DM type II is one of the most common chronic diseases. The objective of this study is to investigate the prevalence of DM and its association with other age-related diseases in Iran, 2012. In this cross-sectional study ...
As an active mom who ate right and exercised on her lunch hour, Lorie Helgeson had no reason to think that she would have a heart attack. Paying attention to her symptoms and getting to a doctor saved her life.
The prominent factors propelling the growth of the global qPCR reagents market include increasing patient population for genetic disorders and infectious diseases, the rise in aged population, and advancement in technologies in the life sciences domain.
Anti-Aging Super HGH Reviews and other Reviews of Nutritional Supplements and Merchants Plus Related Resources Including a 2017 Buying Guide. Healthy Learning for Healthy Living.
Everything about anatomy of mandible, viva voce exam questions and answers on parts, attachments nerve related , age changes and ossification of mandible
Your hands tell your age! Change that with Rejuvents help and expertly applied hand fillers. Dr. Bomer and Dr. Bouzoukis are expert injectors and can help!
Testing can be a good way to detect potential medical problems before they cause illness, but occasionally such vigilant monitoring can be too much of a good thing.
Volunteer with Emmanuel House Home for the Elderly. Find Emmanuel House Home for the Elderly volunteering opportunities at VolunteerMatch!
Your age keeps going up, but the youthfulness of your skin seems to be going downhill. Learn more how to care for your aging skin in The Skinny.
Humorous views on interesting, bizarre and amusing articles, submitted by a community of millions of news junkies, with regular Photoshop contests.
Aging is driven by different factors such as DNA damage and research suggests that NF-kB inhibitors can mitigate cellular damage.
Research focus. My ultimate ambition is to better understand immunosenescence and immune dysregulation over the trajectory of aging, and how these changes relate to compromised health and quality of life in old age. This is particularly important since over the next several decades the world will undergo an unprecedented increase in the proportion of adults over the age of 65. Hence, strategies to promote healthy aging will be critical to minimize the social and economic burdens that are normally associated with elder care. Implicit to this goal is a continual advancement of our understanding of the biology of aging. My research focus features a comprehensive approach that combines epidemiological techniques to identify inherent and modifiable risk factors of age-related disease and morbidity, and in vitro and ex vivo molecular methods to examine potential biological mechanisms. This approach often features immune and inflammation related soluble and cell-associated biomarkers that not only ...
In summary, the research of my laboratory is primarily on age-related degenerative diseases that are characterized by protein conformational changes. It involves studying this alteration, its consequences at the molecular- and system level, the factors that are involved in this process, as well as therapeutic and diagnostic targeting of this pathological pathway.. ...
How TV Shows like Scream Fuel the Young Adult Horror Surge By Dawn Ius Carolyn Lee Adams didnt write Ruthless with the intent of getting it published. Instead, her chilling young-adult debut began as a way to cope with the claustrophobic darkness invading her own life. My marriage was falling apart and this novel
Enter a page name to see changes on pages linked to or from that page. (To see members of a category, enter Category:Name of category). Changes to pages on your Watchlist are in bold. ...
Enter a page name to see changes on pages linked to or from that page. (To see members of a category, enter Category:Name of category). Changes to pages on your Watchlist are in bold. ...