Synonyms for adrenocorticotrophin in Free Thesaurus. Antonyms for adrenocorticotrophin. 6 synonyms for adrenocorticotrophin: ACTH, adrenocorticotrophic hormone, adrenocorticotropic hormone, adrenocorticotropin, corticotrophin, corticotropin. What are synonyms for adrenocorticotrophin?
Define adrenocorticotropic hormone. adrenocorticotropic hormone synonyms, adrenocorticotropic hormone pronunciation, adrenocorticotropic hormone translation, English dictionary definition of adrenocorticotropic hormone. also adrenocorticotrophic hormone n. ACTH. a hormone of the anterior pituitary that stimulates the production of steroids in the cortex of the adrenal...
Define adrenocorticotropic, adrenocorticotrophic hormone. adrenocorticotropic, adrenocorticotrophic hormone synonyms, adrenocorticotropic, adrenocorticotrophic hormone pronunciation, adrenocorticotropic, adrenocorticotrophic hormone translation, English dictionary definition of adrenocorticotropic, adrenocorticotrophic hormone. also cor·ti·co·tro·phin n. See ACTH. a hormone of the anterior pituitary that stimulates the production of steroids in the cortex of the adrenal glands....
elevated ACTH - MedHelps elevated ACTH Center for Information, Symptoms, Resources, Treatments and Tools for elevated ACTH. Find elevated ACTH information, treatments for elevated ACTH and elevated ACTH symptoms.
Several methods for isolating adrenocorticotrophin from small quantities of porcine and bovine pituitary tissue are compared. Initial extraction of the hormone by an acid-acetone technique was simpler and more efficient than one employing acetic acid extraction and ether precipitation. Subsequent purification procedures utilizing adsorption of the peptide on to oxycellulose realized the highest yields. CM-cellulose-column chromatography followed by Sephadex-gel filtration were suitable final steps for obtaining highly purified adrenocorticotrophin. The purity of the hormone was demonstrated by determining its amino acid composition, C-terminal analysis, polyacrylamide-gel electrophoresis, chymotrypsin digestion and paper electrophoresis and by radioimmunoassay and bioassay. Adrenocorticotrophin was found to be rapidly destroyed in intact and especially in homogenized glands kept at room temperature. At 4° the rate of destruction was less rapid and at −20° losses were minimal.. ...
Words you can make out of adrenocorticotrophin. Anagrams of adrenocorticotrophin. Words made after you unscramble adrenocorticotrophin.
Global and Chinese Adrenocorticotropic Hormone Receptor Industry, 2017 Market Research Report is a professional and in-depth study on the current state of the global Adrenocorticotropic Hormone Receptor Market with a focus on the major countries/markets in the world like North America, EU, APAC and ROW.. The report provides key statistics on the market status of the Adrenocorticotropic Hormone Receptor manufacturers and is a valuable source of guidance and direction for companies and individuals interested in the industry.. Firstly, the report provides a basic overview of the industry including its definition, applications and manufacturing technology.. Then, the report explores the international and Chinese major industry players in detail. In this part, the report presents the company profile, product specifications, capacity, production value, and 2013-2017 market shares for each company.. Browse Full Report @: ...
Adrenocorticotropic hormone, β-endorphin and cortisol responses to oCRF in unipolar depressed patients pretreated with dexamethasone ...
CONTEXT Factors that regulate physiological feedback by pulses of glucocorticoids on the hypothalamic-pituitary unit are sparsely defined in humans in relation to gluco- or mineralocorticoid receptor pathways, gender, age, and the sex steroid milieu. OBJECTIVE The objective of the study was to test (the clinical hypothesis) that glucocorticoid (GR) and mineralocorticoid (MR) receptor-selective mechanisms differentially govern pulsatile cortisol-dependent negative feedback on ACTH output (by the hypothalamo-pituitary unit) in men and women studied under experimentally defined T and estradiol depletion and repletion, respectively. SETTING The study was conducted at the Mayo Center for Translational Science Activities. SUBJECTS Healthy middle-aged men (n = 16) and women (n = 25) participated in the study. INTERVENTIONS This was a randomized, prospective, double-blind, placebo- and saline-controlled study of pulsatile cortisol infusions in low cortisol-clamped volunteers with and without eplerenone
This study proposes to provide the reference range of cortisol results when the ACTH stimulation test is done under stressful conditions. This important information is currently not available in the literature. To achieve this, we will perform the ACTH stimulation test in a cohort of patients who are booked for elective surgery. By choosing elective surgery patients, we afford ourselves the opportunity of performing the test once before surgery. The test is then repeated within 12 hours of surgery. The first test will be done on an out-patient basis under usual conditions (minimal stress) while the second will be done under intense physical stress. The 2 sets of results will be compared and the effect of stress on test results will be determined. For the sake of uniformity, we have chosen patients who are booked to undergo repair of an abdominal aortic aneurysm (AAA) as our study cohort.. The ACTH stimulation is an important test that suffers from limitations resulting from lack of clear ...
Synonyms for adrenotropic hormone in Free Thesaurus. Antonyms for adrenotropic hormone. 6 synonyms for adrenocorticotropic hormone: ACTH, adrenocorticotrophic hormone, adrenocorticotrophin, adrenocorticotropin, corticotrophin, corticotropin. What are synonyms for adrenotropic hormone?
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies. ...
The factors that affect synaptogenesis and mTORC are many of the same factors that affect depression. Let me count the ways:. 1. Life adversity causes chronic stress, biologically represented by upregulation of the HPA axis and increased corticosteroid production. A 2008 study finds that rats who are subjected to chronic stress develop atrophy of dendrites in their prefrontal cortex. Administering glucocorticoids directly mimicked some of these effects, suggesting that stress is a whole cocktail of things including glucocorticoids and other things. When humans take glucocorticoids (theyre a useful medicine for various diseases) they tend to develop hippocampal atrophy and "simplification of dendrites" there, which I think is the same as decreased synaptogenesis. They also tend to get depressed - in some studies of Cushings Syndrome (the medical name for the collection of bad things that happen when you take too much glucocorticoid medication), up to 90% of patients are depressed.. 2. I didnt ...
KAGEYAMA Kazunori , NIGAWARA Takeshi , KAMATA Yoshimasa , TAKAHASHI Toshio , ANZAI Jiichi , SUZUKI Shigeharu , OSAMURA Yoshiyuki , SUDA Toshihiro Endocrine journal 49(1), 41-47, 2002-02 J-STAGE 医中誌Web 参考文献16件 被引用文献4件 ...
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Looking for online definition of adrenocorticotropic hormone test in the Medical Dictionary? adrenocorticotropic hormone test explanation free. What is adrenocorticotropic hormone test? Meaning of adrenocorticotropic hormone test medical term. What does adrenocorticotropic hormone test mean?
Looking for online definition of adrenocorticotrophic hormone secreting tumor in the Medical Dictionary? adrenocorticotrophic hormone secreting tumor explanation free. What is adrenocorticotrophic hormone secreting tumor? Meaning of adrenocorticotrophic hormone secreting tumor medical term. What does adrenocorticotrophic hormone secreting tumor mean?
Ectopic adrenocorticotropic hormone secretion is responsible for 12% to 17% of all cases of the Cushing syndrome. One of the most commonly described causes of ectopic adrenocorticotropic hormone secretion is small cell carcinoma of the lung. A rare c
A 37 year old black female presented with congestive cardiac failure, 2 months postpartum. She developed spontaneous hypoglycaemia and symptoms of acute adrenal crisis (hypotension, nausea, abdominal pain and tachycardia with small thready pulse), which responded to i.v. dextrose, sodium chloride and hydrocortisone. Biochemical investigations revealed low serum cortisol and plasma adrenocorticotrophic hormone (ACTH) levels. The patient initially showed an impaired cortisol response to intramuscular aqueous tetracosactrin, but an exuberant response after priming with intramuscular tetracosactrin depot. These findings, together with the normal remaining pituitary function, led us to conclude that this patient had isolated ACTH deficiency associated with congestive cardiac failure and acute adrenal crisis.. ...
Thesis, English, AdrenoCorticoTrophic Hormone &Cortisol serum level in critically ill term and late preterm newborn for Sallam Mona Mahmoud Mustafa
Spontaneous aneurysmal subarachnoid hemorrhage (SAH) is a form of stroke which constitutes a severe trauma to the brain and often leads to serious long-term medical and psychosocial sequels which persist for years after the acute event. Recently, adrenocorticotrophic hormone deficiency has been identified as one possible consequence of the bleeding and is assumed to occur in around 20% of all survivors. Additionally, a number of studies report a high prevalence of post-SAH symptoms such as lack of initiative, fatigue, loss of concentration, impaired quality of life and psychiatric symptoms such as depression. The overlap of these symptoms and those of patients with untreated partial or complete hypopituitarism lead to the suggestion that neuroendocrine dysregulations may contribute to the psychosocial sequels of SAH. Therefore, one of the aims of this work is to gain insights into the role of neuroendocrine dysfunction on quality of life and the prevalence of psychiatric sequels in SAH-patients. ...
The involvement of excitatory amino acids in the control of ACTH release is well established. Activation of ionotropic glutamate receptors has a stimulatory effect on ACTH release, while the role of...
In general, when one perceives a stressful situation, the (limbic)-hypothalamic-pituitary-adrenal (HPA) axis is activated. The HPA axis is a set of neuroendocrine responses to a stressful situation. The paraventricular nucleus of the hypothalamus secretes corticotropin-releasing hormone (CRH) and vasopressin, which are both part of the neuroendocrine system, classified as neurotransmitters and hormones (...animal physiology class is all coming back...). Vasopressin is an anti-diuretic, polypeptide hormone responsible for the bodys conservation of water and plays a key role in the regulation of homeostasis. CRH is also a polypeptide hormone and is responsible for stimulating further stress hormones. CRH is carried to the anterior lobe of the pituitary gland and vasopressin to the to the posterior lobe of the pituitary. CRH stimulates the synthesis and release of adrenocorticotropic hormone (ACTH), which is then released into the bloodstream and stimulates the adrenal glands. The adrenals are two ...
At a Glance Ectopic ACTH syndrome (EAS) is caused by nonpituitary tumors that secrete either adrenocorticotropic hormone (ACTH) and/or corticotropin-releasing hormone (CRH) and cause bilateral adrenal hyperplasia. Clinical presentation resembles Cushings syndrome (CS): amenorrhea, hirsutism, hypertension, impotence, muscular wasting, skin atrophy, neuropsychiatric dysfunction, osteoporosis, truncal-central obesity, weight gain-water retention, moon face, weakness, fatigue, backache, headache,…. ...
Under normal conditions, the brain releases a hormone called adrenocorticotropic hormone (ACTH) that stimulates the adrenal glands to release their hormones. The body has highly developed systems called feedback mechanisms that control, based on the bodys needs, how much of these hormones the adrenal glands produce and release. For example, during times of physical or emotional stress, the body tends to increase the production and release of glucocorticoids (cortisol) to help it deal with the stressful episode. In contrast, when the body is receiving cortisol from an outside source (like a cortisone pill or injection), it reduces the amount of cortisol that the adrenal glands produce.. Two medical conditions, Cushings disease and Addisons disease, occur when the bodys regulation of these hormones is altered; such alterations can cause significant illness in affected pets. Cushings disease occurs when the body produces and releases excessive amounts of cortisol. The clinical term for ...
Under normal conditions, the brain releases a hormone called adrenocorticotropic hormone (ACTH) that stimulates the adrenal glands to release their hormones. The body has highly developed systems called feedback mechanisms that control, based on the bodys needs, how much of these hormones the adrenal glands produce and release. For example, during times of physical or emotional stress, the body tends to increase the production and release of glucocorticoids (cortisol) to help it deal with the stressful episode. In contrast, when the body is receiving cortisol from an outside source (like a cortisone pill or injection), it reduces the amount of cortisol that the adrenal glands produce.. Two medical conditions, Cushings disease and Addisons disease, occur when the bodys regulation of these hormones is altered; such alterations can cause significant illness in affected pets. Cushings disease occurs when the body produces and releases excessive amounts of cortisol. The clinical term for ...
Hypothalamic CRH neurons that control ACTH secretion from the pituitary gland have secretory terminals in the external zone of the median eminence (ZEME). These neurons can coproduce vasopressin (AVP), a neuropeptide that potentiates the ACTH releasing effects of CRH. Recently, we found increased AVP production in adult rats weeks after single exposure to a stressor, which may play a role in event-induced stress disorders. Here, we describe the long-term changes in the HPA axis of adult male rats following a single exposure to a stressor, the cytokine interleukin-1 beta (IL-1 beta). The effects on storage and release of AVP and CRH were established by quantitative immunocytochemistry, the effects on ACTH and corticosterone responses by radioimmunoassay. Single administration of IL-1 beta (5 micrograms/kg i.p.) induces a delayed (at least 4 d) and a long-lasting (at least 3 weeks) increase of vasopressin (AVP) stores in CRH terminals of the ZEME without affecting the CRH stores, and a marked ...
To the Editor.-Despite the recent findings of Cunningham et al,1 the synthetic adrenocorticotropic hormone (ACTH) test remains the best technique for establishi
Radiotherapy may be recommended if pituitary gland surgery doesnt achieve a cure or if youre unable to have surgery. It involves using high-energy X-rays to shrink the tumour and stop it producing adrenocorticotropin hormones (ACTH).. Normal radiotherapy is delivered daily in small doses over a period of five weeks. This helps to reduce damage to other areas of the brain.. However, a type of radiotherapy known as stereotactic radiosurgery (SRS) is increasingly being used to treat pituitary tumours. This uses a series of movable frames to hold your head in a precise position. A computer is then used to send energy rays to the exact location of the pituitary tumour. The precise focusing of SRS is thought to minimise the chances of other parts of your brain being accidentally damaged. The whole radiation dose is delivered in just one session. As the procedure is only available at a number of specialised centres, its likely youll have to travel to receive treatment.. Both types of radiotherapy ...
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Your sympathetic ANS is responsible for your "flight or fight" reaction when presented with a stressful situation. When you are presented with a stressful situation, your hypothalamus releases a chemical messenger that travels to your pituitary gland, which is then stimulated to produce adrenocorticotrophic hormone (ACTH). The (ACTH) then travels through you blood stream to your adrenal gland, where it stimulates the outer layer of your adrenal gland in order to produce corticoids. Corticoids help to acquire from energy stores within your body. Simultaneously, the hypothalamus activates the inner portion of the adrenal gland, which produces epinephrine, also known as adrenaline. Adrenaline causes your bodies physiological responses to become heightened for a short period of time as your body braces for action ...
Your sympathetic ANS is responsible for your "flight or fight" reaction when presented with a stressful situation. When you are presented with a stressful situation, your hypothalamus releases a chemical messenger that travels to your pituitary gland, which is then stimulated to produce adrenocorticotrophic hormone (ACTH). The (ACTH) then travels through you blood stream to your adrenal gland, where it stimulates the outer layer of your adrenal gland in order to produce corticoids. Corticoids help to acquire from energy stores within your body. Simultaneously, the hypothalamus activates the inner portion of the adrenal gland, which produces epinephrine, also known as adrenaline. Adrenaline causes your bodies physiological responses to become heightened for a short period of time as your body braces for action ...
How often do you practice the power of appreciation and an "attitude of gratitude" throughout the day?. How often do you practice a stress management method, meditation, etc?. How often do you feel "stressed out"?. Stress is your response to unusual demands made on you. What is Your stress level? You can respond positively or negatively, which is distress. The effects of stress depend on your response to the demands. Sometimes, you are your own worst enemy when it comes to stress.. Stress causes hormones in your hypothalamus (an are of your brain stem) to be secreted. This causes the pituitary gland to stimulate the production of adrenocorticotropic hormone (ACTH). ACTH travels through the blood stream from the pituitary gland to the adrenal gland. The adrenal gland stimulates the release of cortisol. Cortisol activates your brains reward center and increases levels of insulin in the blood stream, stimulating the desire for high-fat high-sugar foods.. Here are some ways to be more productive ...
How often do you practice the power of appreciation and an "attitude of gratitude" throughout the day?. How often do you practice a stress management method, meditation, etc?. How often do you feel "stressed out"?. Stress is your response to unusual demands made on you. What is Your stress level? You can respond positively or negatively, which is distress. The effects of stress depend on your response to the demands. Sometimes, you are your own worst enemy when it comes to stress.. Stress causes hormones in your hypothalamus (an are of your brain stem) to be secreted. This causes the pituitary gland to stimulate the production of adrenocorticotropic hormone (ACTH). ACTH travels through the blood stream from the pituitary gland to the adrenal gland. The adrenal gland stimulates the release of cortisol. Cortisol activates your brains reward center and increases levels of insulin in the blood stream, stimulating the desire for high-fat high-sugar foods.. Here are some ways to be more productive ...
Until recently ACTH was regarded as a single, well-defined polypeptide of 39 amino acids. The structure of ACTH derived from the pituitary gland of several species, its physical chemistry and...
In health: In order to understand Cushings disease, one needs to understand the basics of the negative feedback loop that operates in a normal, healthy dog. The pituitary gland, located at the base of the brain, produces ACTH (adrenocorticotrophic hormone), as directed by the hypothalamus (another part of the brain). This hormone is released into the bloodstream and stimulates the bodys two adrenal glands, located near the kidneys, to secrete glucocorticoid (cortisone-like or cortisol) hormones into the bloodstream. Cortisol helps the body respond to stress. It is necessary for life and impacts a wide variety of bodily functions including blood sugar levels, fat metabolism, skeletal muscles, kidney function, nervous system, cardiovascular system, and immune response. ACTH/cortisol secretion is increased due to stress, including infection, pain, surgery, trauma, cold temperatures. When the blood cortisol levels are high enough, the pituitary stops secreting ACTH. When the blood cortisol levels ...
The proposed studies are based on our previous findings that in late gestation, basal plasma Cortisol levels are normal in the long-term hypoxic (LTH) sheep fet...
Principal Investigator:SASANO Hironobu, Project Period (FY):1994 - 1995, Research Category:Grant-in-Aid for General Scientific Research (C), Research Field:Human pathology
In the fall, measuring a horses adrenocorticotropic hormone (ACTH) levels is often used as a diagnostic tool for pituitary pars intermedia dysfunction (PPID, also known as equine Cushings disease). It peaks between mid-August to mid-October as part of the metabolic preparation for winter and results in levels anywhere up to about three times those found…
Tetracosactide (also known as Cosyntropin) is a synthetic peptide that is identical to the 24-amino acid segment (sequence: SYSMEHFRWGKPVGKKRRPVKVYP) at the N-terminal of adrenocorticotropic hormone. ACTH (1-24), a segment similar in all species, contains the biological activity that stimulates production of corticosteroids in the adrenal cortex. Tetracosactide exhibits the same activity as natural ACTH with regard to all its biological activities. The complex results in a product whose absorption in man is effected over a longer period of time as compared to corticotropin. Therefore, therapy may be maintained with less frequent administration.
Stress is what our body goes through when we perceive our environment as changing. Stress can be "good stress" or "bad stress." We all understand bad stress, everyone has experienced it and has had to deal with its negative effects. However, did you know that good stress, e.g., going on vacation, finally getting that promotion or bringing a new member into the family, can also be quite hard on our bodies?. When our brains perceive that something is about to happen it triggers several chemical reactions. First, the pituitary gland releases the hormone ACTH into the bloodstream. Once the adrenal glands detect the ACTH, they secrete hormones and natural cortisone into the bloodstream. These chemicals combine to create steroids. These steroids then do their best Paul Revere impersonation by racing through the body announcing "Be ready! Something is about to happen! Change is coming! Change is coming!". The body responds to this stimulus by preparing itself for "fight or flight." The liver releases ...
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We have shown previously that chronic administration of adrenocorticotropic hormone (ACTH) causes a significant decrease in hippocampal cell proliferation and neurogenesis. This effect in rats treated chronically with ACTH was not influenced by the chronic administration of imipramine, but was reversed by coadministration of imipramine and lithium. The present study was undertaken to further characterize the mechanism underlying the effect of imipramine and lithium on hippocampal cell proliferation and neurogenesis, by investigating the effects of treatment on the expression of brain-derived neurotrophic factor (BDNF), total cyclic adenosine monophosphate response element-binding protein (CREB), and phosphorylated CREB (pCREB) of the CREB signaling system, as well as Wnt 3a and cyclin D1 of the Wnt signaling pathway in the hippocampus of saline- and ACTH-treated rats. ACTH treatment significantly decreased the expression of cyclin D1. Treatment with imipramine and lithium increased the expression of
TY - JOUR. T1 - Arginine vasopressin is a much more potent stimulus to acth release from ovine anterior pituitary cells than ovine corticotropin-releasing factor. T2 - 1. In vitro studies. AU - Familari, Mlary. AU - Smith, A. Ian. AU - Smith, Robin. AU - Funder, John W.. PY - 1989/1/1. Y1 - 1989/1/1. N2 - Cultured rat and ovine anterior pituitary cells were treated with a range of doses (0.01-1,000 nM) of arginine vasopressin (AVP) and ovine corticotropin-releasing factor (CRF), alone or in combination, and medium and cell content of immuno-reactive (ir-)ACTH determined. In rat cells, a dose-response curve to CRF was obtained, with a threshold dose of 0.1 nM\ A VP was much less effective alone, but augmented CRF responses when administered with CRF. In ovine pituitary cells AVP markedly stimulated ACTH release in a dose-dependent fashion, and with a threshold of 0.1 nM\ in contrast, CRF increased ACTH release over basal only at doses , 100 nM. In combination, subthreshold doses of AVP ...
en] We aimed to investigate the dynamics of adrenocorticotropin (ACTH) and cortisol secretion in pituitary-dependent Cushings syndrome with bilateral macronodular adrenal hyperplasia presenting as a single adrenal macronodule, and to determine the imaging characteristics of this syndrome. Three female patients were studied. Plasma ACTH and serum cortisol secretion were studied by determining their rhythmicity and pulsatility and their responses to the administration of ovine corticotropin-releasing factor, thyrotropin-releasing hormone, metyrapone, tetracosactrin, insulin and dexamethasone. Techniques used to localize the anatomical lesion were bilateral simultaneous inferior petrosal sinus sampling, magnetic resonance examination of the pituitary, computed tomography (CT) scanning and [75Se]cholesterol scintigraphy of the adrenal glands. Plasma ACTH and serum cortisol levels were measured using a commercial radioimmunoassay and an immunoradiometric assay. The ACTH and cortisol pulse number and ...
TY - JOUR. T1 - Gender differences in cardiovascular and hypothalamic-pituitary-adrenal axis responses to psychological stress in healthy older adult men and women. AU - Traustadottir, Tinna. AU - Bosch, Pamela R. AU - Matt, K. S.. PY - 2003/6. Y1 - 2003/6. N2 - Gender differences in the neuroendocrine and cardiovascular response to psychological stress may contribute to the gender differences in the prevalence of diseases associated with hypothalamic-pituitary-adrenal (HPA) axis reactivity such as cardiovascular disease (CVD), diabetes and hypertension. We measured plasma ACTH, cortisol, heart rate (HR), and blood pressure (BP) responses in 8 men and 8 women (55-75 years) exposed to the Matt Stress Reactivity Protocol (MSRP), a psychological challenge. The MSRP elicited significant increases in HR, systolic-, and diastolic BP, ACTH and cortisol (all p , 0.01). Men had significantly greater cortisol and diastolic BP responses compared to women (p , 0.05). Additionally, a positive correlation ...
Xu, Y., Day, Trevor A. and Buller, K. M. 1999, The central amygdala modulates hypothalamic-pituitary-adrenal axis responses to systemic interleukin-1beta administration, Neuroscience, vol. 94, no. 1, pp. 175-183, doi: 10.1016/S0306-4522(99)00311-5. ...
TY - JOUR. T1 - Ionic currents in two strains of rat anterior pituitary tumor cells. AU - Dubinsky, Janet M.. AU - Oxford, Gerry S.. PY - 1984/3/1. Y1 - 1984/3/1. N2 - The ionic conductance mechanisms underlying action potential behavior in GH3 and GH4/C1 rat pituitary tumor cell lines were identified and characterized using a patch electrode voltage-clamp technique. Voltage-dependent sodium, calcium, and potassium currents and calcium-activated potassium currents were present in the GH3 cells, GH4/C1 cells possess much less sodium current, less voltage-dependent potassium current, and comparable amounts of calcium current. Voltage-dependent inward sodium current activated and inactivated rapidly and was blocked by tetrodotoxin. A slower-activating voltage-dependent inward calcium current was blocked by cobalt, manganese, nickel, zinc, or cadium. Barium was substituted for calcium as the inward current carrier. Calcium tail currents decay with two exponential components. The rate constant for ...
The long-term consequences of neonatal endotoxin exposure on hypothalamic-pituitary-adrenal axis (HPA) function were assessed in adult female and male Long-Evans rats. At 3 and 5 d of age, pups were administered endotoxin (Salmonella enteritidis, 0.05 mg/kg, i.p.) at a dose that provokes a rapid and sustained physiological response, but with no mortality. As adults, neonatally endotoxin-treated animals exhibited significantly greater adrenocorticotrophic hormone (ACTH) and corticosterone responses to restraint stress than controls. In addition, dexamethasone pretreatment was less effective in suppressing ACTH responses to restraint stress in endotoxin-treated animals than in controls, suggesting decreased negative-feedback sensitivity to glucocorticoids. Neonatal endotoxin treatment elevated resting-state median eminence levels of corticotropin-releasing hormone (CRH) and arginine vasopressin in adult male animals, and arginine vasopressin in both adult males and females. Neonatal exposure to ...
Sources Used in Current Review. (Revised 2010 April 29). Adrenal hyperfunction (Cushing syndrome) testing. Arup Consult. Available online at https://arupconsult.com/sites/default/files/Adrenal%20Hyperfunction%20Testing%20algorithm.pdf. Accessed October 2016.. Elhomsy, G. (2014 September 5). Adrenocorticotropin (ACTH). Medscape Reference. Available online at http://emedicine.medscape.com/article/2088760-overview#a2. Accessed October 2016.. (Updated 2015 September 28). Addison Disease Workup. Medscape Reference. Available online at http://emedicine.medscape.com/article/116467-overview. Accessed October 2016.. (Updated 2015 October 28) Addison disease. MedlinePlus. Available online at https://www.nlm.nih.gov/medlineplus/ency/article/000378.htm. Accessed October 2016.. (Updated 2015 October 28). Cushing Disease. MedlinePlus. Available online at https://www.nlm.nih.gov/medlineplus/ency/article/000348.htm. Accessed October 2016.. (Updated 2015 October 28) ACTH stimulation test. MedlinePlus. Available ...