Synonyms for alpha-blocking agent in Free Thesaurus. Antonyms for alpha-blocking agent. 2 synonyms for alpha: first and last, be-all and end-all. What are synonyms for alpha-blocking agent?
Alpha blockers lower blood pressure by keeping the hormone norepinephrine from tightening the muscles in the walls of smaller arteries and veins. As a result, the vessels remain open and relaxed. This improves blood flow and lowers blood pressure.. Because alpha blockers also relax other muscles throughout the body, these medications also can help improve urine flow in older men with prostate problems.. Alpha blockers are either short-acting or long-acting. Short-acting medications work quickly, but their effects last only a few hours. Long-acting medications take longer to work, but their effects last longer. The alpha blocker thats best for you depends on your health and the condition being treated.. Alpha blockers are also called alpha-adrenergic blocking agents, alpha-adrenergic antagonists, adrenergic blocking agents and alpha-blocking agents.. Examples of alpha blockers used to treat high blood pressure include:. ...
Several important results were obtained from the present studies. First, in accordance with many previous reports, PCP was found repeatedly to disrupt PPI (Bakshi and Geyer, 1995; Bakshi et al., 1994; Mansbach and Geyer, 1989; Swerdlow et al., 1996; Wiley, 1994; Varty and Higgins, 1994; Johansson et al., 1994b). Second, the selective alpha-1 noradrenergic antagonist prazosin prevented the PCP-induced deficit in PPI. This effect was produced by multiple prazosin doses, was observed over multiple prepulse intensities and was replicated in a second separate experiment. Finally, selective antagonists for eitheralpha-2 (RX821002), muscarinic M1 (pirenzepine) or GABA-A (pitrazepin) receptors had no effect on the disruption of PPI produced by PCP. Taken together, these results indicate strongly that the impairment of sensorimotor gating induced by PCP involves the presumably indirect activation of alpha-1 adrenergic receptors, but probably not alpha-2, M1 or GABA-A receptors.. To the best of our ...
Define alpha-blocker. alpha-blocker synonyms, alpha-blocker pronunciation, alpha-blocker translation, English dictionary definition of alpha-blocker. n. A drug that blocks or counteracts the effects of epinephrine and other molecules that stimulate alpha-receptors, leading to various physiological...
Alpha-blockers, also known as α-blockers or α-adrenoreceptor antagonists, are a class of pharmacological agents that act as antagonists on α-adrenergic receptors (α-adrenoceptors). Historically, alpha-blockers were used as a tool for pharmacologic research to develop a greater understanding of the autonomic nervous system. Using alpha blockers, scientists began characterizing arterial blood pressure and central vasomotor control in the autonomic nervous system. Today, they can be used as clinical treatments for a limited number of diseases. Although alpha blockers can only treat a small range of diseases, some of them have clinical uses, such as having the ability to treat hypertension, Raynauds disease, Congestive Heart Failure, erectile dysfunction, etc. Generally speaking, all of these treatments function by binding an α-blocker to α receptors in the arteries and smooth muscle. Ultimately, this relaxes the smooth muscle or blood vessels, which increases fluid flow in these entities. ...
Ioannides, C, Okine, L and Parke, DV (1979) Effects of β-adrenoceptor antagonists on the hepatic mixed-function oxygenases in the rat ...
BACKGROUND AND PURPOSE: In mouse tail arteries, selective alpha(2)-adrenoceptor antagonism with rauwolscine caused powerful dilation during constriction to the alpha(1)-adrenoceptor agonist phenylephrine. This study therefore assessed phenylephrines selectivity at vascular alpha-adrenoceptors and the mechanism(s) underlying dilation to rauwolscine. EXPERIMENTAL APPROACH: Mouse isolated tail arter
Among medical therapies used to treat BPH, alpha-adrenergic blockers tend to be used most. There are 4 alpha blocker drugs used to treat BPH: Cardura, Flomax, Hytrin, and Uroxatral.
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YM 161514 [YM 161511, YM 151], a calcium antagonist and β1-adrenoceptor antagonist, was under investigation with Yamanouchi as a potential treatment for
Looking for online definition of alpha (alpha)-adrenoceptor antagonist in the Medical Dictionary? alpha (alpha)-adrenoceptor antagonist explanation free. What is alpha (alpha)-adrenoceptor antagonist? Meaning of alpha (alpha)-adrenoceptor antagonist medical term. What does alpha (alpha)-adrenoceptor antagonist mean?
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Vigamed (Phentolamine Mesylate) is used to treat sexual dysfunction symptoms such as impotence, and ejaculatory failures. Vigamed controls the erection process through the bodys sympathetic system allowing blood to flow into the penis to form an erection.
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Several important results were obtained from the present studies. First, in accordance with many previous reports, PCP was found repeatedly to disrupt PPI (Bakshi and Geyer, 1995; Bakshi et al., 1994; Mansbach and Geyer, 1989; Swerdlow et al., 1996; Wiley, 1994; Varty and Higgins, 1994; Johansson et al., 1994b). Second, the selective alpha-1 noradrenergic antagonist prazosin prevented the PCP-induced deficit in PPI. This effect was produced by multiple prazosin doses, was observed over multiple prepulse intensities and was replicated in a second separate experiment. Finally, selective antagonists for eitheralpha-2 (RX821002), muscarinic M1 (pirenzepine) or GABA-A (pitrazepin) receptors had no effect on the disruption of PPI produced by PCP. Taken together, these results indicate strongly that the impairment of sensorimotor gating induced by PCP involves the presumably indirect activation of alpha-1 adrenergic receptors, but probably not alpha-2, M1 or GABA-A receptors.. To the best of our ...
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Hytrin is an alpha-adrenergic blocker, which relaxes blood vessels. It is prescribed to treat hypertension and benign prostatic hyperplasia.
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This review evaluates the role of α-adrenoceptor antagonists as a potential treatment of prostate cancer (PCa). Cochrane, Google Scholar and Pubmed were accessed to retrieve sixty-two articles for analysis. In vitro studies demonstrate that doxazosin, prazosin and terazosin (quinazoline α-antagonists) induce apoptosis, decrease cell growth, and proliferation in PC-3, LNCaP and DU-145 cell lines. Similarly, the piperazine based naftopidil induced cell cycle arrest and death in LNCaP-E9 cell lines. In contrast, sulphonamide based tamsulosin did not exhibit these effects. In vivo data was consistent with in vitro findings as the quinazoline based α-antagonists prevented angiogenesis and decreased tumour mass in mice models of PCa. Mechanistically the cytotoxic and antitumor effects of the α-antagonists appear largely independent of α 1-blockade. The proposed targets include: VEGF, EGFR, HER2/Neu, caspase 8/3, topoisomerase 1 and other mitochondrial apoptotic inducing factors. These cytotoxic effects
This review evaluates the role of α-adrenoceptor antagonists as a potential treatment of prostate cancer (PCa). Cochrane, Google Scholar and Pubmed were accessed to retrieve sixty-two articles for analysis. In vitro studies demonstrate that doxazosin, prazosin and terazosin (quinazoline α-antagonists) induce apoptosis, decrease cell growth, and proliferation in PC-3, LNCaP and DU-145 cell lines. Similarly, the piperazine based naftopidil induced cell cycle arrest and death in LNCaP-E9 cell lines. In contrast, sulphonamide based tamsulosin did not exhibit these effects. In vivo data was consistent with in vitro findings as the quinazoline based α-antagonists prevented angiogenesis and decreased tumour mass in mice models of PCa. Mechanistically the cytotoxic and antitumor effects of the α-antagonists appear largely independent of α 1-blockade. The proposed targets include: VEGF, EGFR, HER2/Neu, caspase 8/3, topoisomerase 1 and other mitochondrial apoptotic inducing factors. These cytotoxic effects
Flomax is a drug that is often used to treat benign prostatic hyperplasia (BPH). It is an alpha-blocker and it affects the hormones adrenaline and noradrenaline. There may be side effects, and other drugs may be used. Home remedies can also help relieve symptoms. Find out more about Flomax and other treatment options.
The exact mechanism of the hypotensive action of prazosin is unknown. Prazosin causes a decrease in total peripheral resistance and was originally thought to have a direct relaxant action on vascular smooth muscle. Recent animal studies, however, have suggested that the vasodilator effect of prazosin is also related to blockade of postsynaptic alpha-adrenoceptors. The results of dog forelimb experiments demonstrate that the peripheral vasodilator effect of prazosin is confined mainly to the level of the resistance vessels (arterioles). Unlike conventional alpha-blockers, the antihypertensive action of prazosin is usually not accompanied by a reflex tachycardia. Tolerance has not been observed to develop in long term therapy.. Hemodynamic studies have been carried out in man following acute single dose administration and during the course of long term maintenance therapy. The results confirm that the therapeutic effect is a fall in blood pressure unaccompanied by a clinically significant change ...
Minipress is classified as an alpha-adrenergic blocker. The active ingredient of the medication, Prazosin, stimulates an inevitable action relaxing the arteries and veins. This way, the treatment produces easier blood circulation in the body.
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Hytrin is an alpha-adrenergic blocker, which relaxes blood vessels. It is prescribed to treat hypertension and benign prostatic hyperplasia.
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Doxazosin is an alpha-adrenergic (AL-fa ad-ren-ER-jik) blockers. Doxazosin relaxes your veins and arteries so that blood can more easily pass through them. It also relaxes the muscles in the prostate and bladder neck, making it easier to urinate. Doxazosin is used to treat hypertension (high blood pressure), or to...
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The purpose of this study is to explore additional benefit of solifenacin after 12-week treatment, compared with alpha blocker monotherapy in men with residual
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Prazosin, 1-(4-amino-6,7-dimetoksi-2-hinazolinil)-4-(2-furoil)-piperazin, se sintetiše iz 2-amino-4,5-dimetoksibenzoinske kiseline, koji nakon reakcije sa natrijum cijanatom podleže heterociklizaciji do 2,4-dihidroksi-6,7-dimetoksihinazolina. Supstituisanje hidroksilnih grupa ovog jedinjenja atomima hlora reakcijom sa tionil hloridom, ili smešom fosfor oksihlorida sa fosfor pentahloridom daje 2,4-dihloro-6,7-dimetoksihinazolin. Naknadnom reakcijom sa amonijakom, atom hlora u C4 poziciji pirimidinskog prstena se zamenjuje amino grupom, što dovodi do formiranja 4-amino-2-hloro-6,7-dimetoksihinazolina. Njegovim uvođenjem u reakciju sa 1-(2-furoil)piperazinom formira se prazosin.[3][4][5][6][7][8][9][10][11][12]. ...
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