Commissioner Weston asked if we are going to try to make this policy cover those types of projects like we ran into in Cache Valley with the sidewalk program. Howard Richardson replied that the policy principally deals with curb, gutter and sidewalk replacement; the management, jurisdiction and maintenance of it. Commissioner Weston referred to a section of the policy which says, ". . . on Federal-aid projects where the facilities are not eligible for Federal funds any funds made available by legislative appropriations, contributions of property owners, cities, counties, other parties or any combination of the foregoing will be used." He said that seems pretty inclusive and covers most any sidewalk with which were involved whether its sidewalk money, or any other kind. His concern, as he has mentioned before, is that we pass the money through in the sidewalk program, and then let it die. They put the sidewalks in and we may look at them or we may not. Are we looking at that closely enough when ...
The effect of beta adrenergic agents on granulocyte deformability was investigated using the filtration technique. Three groups of granulocytes were studied: 1) cells treated with isoproterenol (10−6 to 10−3 M); 2) cells treated with propranolol (10−
Atenololo, un beta competitivo (1)-adrenergici antagonista selettivo, ha la più bassa solubilità lipidica di questa classe di farmaci. Anche se è simile al metoprololo, atenololo differisce da pindololo e propranololo in quanto non ha caratteristiche intrinseche simpaticomimetica o attività stabilizzante di membrana. Latenololo è usato da solo o con clortalidone nella gestione di ipertensione ed edema ...
The role of norepinephrine in the development of amygdaloid kindling in rats was investigated. In the first experiment, pretreatment with the noradrenergic neurotoxin, DSP-4 (63 mg/kg, ip), whose action is reportedly specific to locus coeruleus neurons, markedly accelerated the rate of kindling. DSP-4 treated animals and saline controls required 3.8 and 7.5 after-discharges (ADs) to kindle respectively. Furthermore, DSP-4 treatment lengthened the latency of the onset to clonus during the first stage 5 seizure. Norepinephrine levels measured in the telencephalon were lowered by 45% with DSP-4 treatment, whereas dopamine and 5-hydroxytryptamine levels were unaffected. -- In an attempt to test the hypothesis that a tonic presence of norepinephrine serves to inhibit kindling development, rats were treated with DSP-4, and chronically infused (icv) with either norepinephrine (5 ug/.5 ul/hr), or the vehicle, via an osmotic minipump. Telencephalic norepinephrine levels were not raised by the infusion of ...
Heuer, A., Smith, G. A. and Dunnett, S. B. (2013), Comparison of 6-hydroxydopamine lesions of the substantia nigra and the medial forebrain bundle on a lateralised choice reaction time task in mice. European Journal of Neuroscience, 37: 294-302. doi: 10.1111/ejn.12036 ...
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RT-PCR data showed that the mRNA levels of gammaGCS, the rate-limiting enzyme of gamma-L-glutamyl-L-cysteinylglycine (GSH) synthesis, were increased by 6-OHDA after treatment for 24 h and 48 h; the mRNA levels of GPx, GR, and GST did not alter in 6-OHDA-treated astrocytes after treatment for 24 h and 48 h; and 6-OHDA increased the mRNA levels and the activity of gammaGT after treatment for 48 h, which induced a decrease in GSx levels, despite the up-regulation of gammaGCS after exposure to 6-OHDA for 48 h." (15960885) ...
TY - JOUR. T1 - α2-adrenergic modulation of colonic tone during hyperventilation. AU - Bharucha, Adil E.. AU - Novak, Vera. AU - Camilleri, Michael. AU - Zinsmeister, Alan R.. AU - Hanson, Russell B.. AU - Low, Phillip A.. PY - 1997. Y1 - 1997. N2 - Our aims were to assess the role of adrenergic modulation in the hyperventilation-induced increase in colonic tone. Of 40 healthy volunteers, 12 received placebo (saline) and the remaining 28 received either clonidine, yohimbine, phenylephrine, or ritodrine. Time-frequency mapping of heart rate based on Wigner distribution assessed variations in parasympathetic and sympathetic activity during hyperventilation. Tone in the descending colon was recorded by a barostat balloon before, during, and after 5 min of hyperventilation. Heart rate spectral analysis suggested diminished sympathetic and vagal activity during hyperventilation and increased sympathetic and vagal activity after hyperventilation. Adrenergic agents influenced (P = 0.01) the tonic ...
The adrenergic amines noradrenaline and adrenaline increased flux through phenylalanine hydroxylase by approx. 50%. This effect, which appears to be mediated by an alpha-adrenergic mechanism, was accompanied by a rapid increase in the phosphorylation of phenylalanine hydroxylase. Although ionophore A23187 mimicked the effects of the adrenergic amines, vasopressin was completely without effect on either phenylalanine hydroxylation or enzyme phosphorylation. Flux through phenylalanine hydroxylase in young rats (80 g) was insensitive to alpha-adrenergic, but sensitive to beta-adrenergic, agents. Consistent with previous observations [Fisher & Pogson (1984) Biochem. J. 219, 79-85] the present data indicate a close correlation between phosphorylation state and flux rate (i.e. enzyme activity). ...
The lack of β-adrenergic modulation in VEDS cardiomyocytes suggests that one or more components of the signaling cascade were missing or functionally inactive. To identify these components, we assayed the functional activity of different elements in the β-adrenergic enzymatic cascade. A key finding was that ICaL was strongly stimulated by cell dialysis with the catalytic subunit of PKA in both VEDS and LDS cardiomyocytes. In contrast to a previous report6 in which fast current rundown was observed using Ba2+ as a charge carrier, we could accurately measure the stimulating effect of the catalytic subunit of PKA on ICaL in VEDS cardiomyocytes. The catalytic subunit of PKA produced a maximal ICaL stimulation. Importantly, ICaL stimulation by the catalytic subunit of PKA was found to be similar (≈3 times) in VEDS, LDS, and ventricular cardiomyocytes isolated from the adult mouse heart. These data provide strong evidence for similar structural properties of the Ca2+ channel or a closely related ...
Anfetamine e destroanfetamina, agenti sypathomimetic non catechloamine, sono utilizzati in combinazione per il trattamento di deficit di attenzione e iperattività (ADHD) o di narcolessia. Adderall è costituito da equivalente quantità di aspartato anfetamine, solfato di anfetamina, saccarato destroanfetamina e solfato destroanfetamina ...
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OBJECTIVE: Myocardial damage induced by isoproterenol is believed to be secondary to increased oxygen demands on the heart. Our objective was to test an additional primary action of isoproterenol on tissue and mitochondrial oxidative metabolism and to compare these effects with the effects of other adrenergic agents in the presence of adrenergic inhibitors. DESIGN: Prospective, dose-response study. SETTING: Research laboratory at a university hospital. SUBJECTS: Fifty Sprague-Dawley female rats (200 to 350 g), slightly anesthetized with ether and divided into several groups. INTERVENTIONS: In 26 rats, the heart was removed, cut into fine slices (0.5-mm thickness), and placed in an ice-cold buffer. In 22 animals, the hearts were perfused in the Langendorff manner and chopped and processed for mitochondrial studies. MEASUREMENTS AND MAIN RESULTS: We determined the following: a) the direct "in vitro" effects of isoproterenol and related catecholamines on normal oxygen uptake using myocardial ...
3H]Dihydroergocryptine, a nonselective alpha adrenergic antagonist, the alpha-1 selective antagonist, [3H]prazosin and the alpha-2 selective antagonist, [3H]yohimbine, were used to study binding sites in rat renal membranes. To establish a correlation between binding and a biological function, the ability of alpha adrenergic agents to stimulate or inhibit vasoconstriction was quantified in vitro using an isolated perfused kidney preparation. Binding with each radioligand was rapid, saturable and specific. Moreover, the order of potencies of a variety of adrenergic agents, determined by competitive inhibition studies, suggested that the binding of each radioligand was to sites with alpha adrenergic specificity. The total number of binding sites in these rat renal membranes. determined with [3H]dihydroergocryptine (Bmax, 212 fmol/mg of protein; KD, 12.8 nM) was approximately equal to the sum of binding site concentrations determined with the alpha-1 and alpha-2 selective radioligands (Bmax, 57 and ...
&splt;p>Sagger Mawri, MD and Khalid George, MD&splt;/p> &splt;p>December 11, 2015&splt;/p> &splt;p>A 64-year-old woman with history of lumbar compression fracture status post L3-L5 kyphoplasty two weeks prior presented to the emergency department complaining of worsening lower extremity weakness since her spinal surgery. Her symptoms became severe and limited her ability to stand or ambulate. She also endorsed urinary and bowel incontinence. On examination, she demonstrated moderately reduced bilateral lower extremity strength and reduced rectal tone without sensory deficits or clonus. Computed tomography with contrast is obtained.&spamp;nbsp;&splt;/p> &splt;div>&splt;img src=&doublequot;http://www.sgim.org/Image Library/JGIM/Web Only/Clinical Images/Cement-in-IVC.jpg&doublequot; alt=&doublequot;cement in ivc&doublequot; objectid=&doublequot;2e147345-cd18-4229-b9dd-0c7bcc216c14&doublequot; imagesiteid=&doublequot;8039ce09-e7da-47e1-bcec-df96b5e411f4&doublequot; />&splt;/div> &splt;p>&spamp;nbsp;&splt;/p
In the present study, in agreement with others (Breese and Traylor, 1971, 1972; Breese et al., 1984), there was an extensive reduction in the neostriatal content of DA (97%), HVA (98%) and DOPAC (89%) in 6-OHDA-treated rats, regardless of HAL treatment (table 1). Neostriatal NE content was unaltered, probably reflecting effectiveness of desipramine pretreatment in protecting noradrenergic neurons from 6-OHDA destruction. As expected, neostriatal concentrations of 5-HT and 5-HIAA were significantly elevated by neonatal 6-OHDA treatment (table 1, P , .01), reflecting the known proliferative sprouting of 5-HT fibers in the forebrain of rats lesioned neonatally with 6-OHDA (Stachowiak et al., 1984;Berger et al., 1985; Snyder et al., 1986).. Spontaneous oral activity of intact rats remained at a consistently low level for the entire duration of the experiment (fig. 1). Also, neonatal 6-OHDA treatment alone did not increase the level of spontaneous oral activity (fig. 1). The HAL dose (1.5 mg/kg/day) ...
Guanethidine Sulfate is a medicine available in a number of countries worldwide. A list of US medications equivalent to Guanethidine Sulfate is available on the Drugs.com website.
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1. Only serious buyers. Be 100% sure that you want to purchase the items before placing an order. Please do not back out after confirming order. If youre not interested in the item anymore, please do inform us ...
光大 guāngdà, splendid/magnificent/abbr. for 中國光大銀行,中国光大银行[Zhōng guó Guāng dà Yín háng], China ...