TY - JOUR. T1 - Laparoscopic resection of adrenal cortical carcinoma. T2 - A cautionary note. AU - Gonzalez, Ricardo J.. AU - Shapiro, Suzanne. AU - Sarlis, Nicholas. AU - Vassilopoulou-Sellin, Rena. AU - Perrier, Nancy D.. AU - Evans, Douglas B.. AU - Lee, Jeffrey E.. AU - Inabnet, William B.. AU - Libutti, Steven K.. AU - Chen, Herbert. AU - Duh, Quan Yang. AU - Wilhelm, Scott. PY - 2005/12/1. Y1 - 2005/12/1. N2 - Background. While laparoscopic removal of small, benign, functioning adrenal tumors is accepted, laparoscopic resection of adrenal tumors that may be adrenal cortical carcinoma (ACC) remains controversial. Methods. The records of all patients with ACC evaluated at a single institution from 1991 through 2004 were reviewed retrospectively. Results. Among 170 patients with ACC, 153 patients underwent open anterior adrenalectomy, 6 underwent laparoscopic adrenalectomy, 1 was treated via an open flank approach, and 10 had no operation. At a median follow-up of 28 months, 115 (86%) of 133 ...
The focus on the refinement, reduction and replacement of animal use in toxicity testing requires the development of cell-based systems that mimic the effects of xenobiotics in human tissues. The human adrenocortical carcinoma cell line, H295R, has been
1. The major issue to resolve with the various imaging techniques is the differentiation of benign adrenal adenomas from adrenal cortical carcinoma, since biochemical tests can distinguish an adrenal adenoma from a pheochromocytoma. As Dr. Copeland has noted, approximately half of the adrenal masses in patients with known cancer represent metastasis (1). It is in that group of patients that fine-needle aspiration of the adrenal mass is most useful in excluding metastatic disease if the findings on imaging are equivocal. In the study Dr. Copeland cites to advocate the routine use of delayed enhanced CT (2), 39 of the 40 malignant adrenal incidentalomas were metastatic lesions, while the remaining lesion was a malignant pheochromocytoma. None were adrenal cortical carcinomas. Until we have sufficient data that this procedure regularly distinguishes between primary adrenal adenomas and carcinomas, "additional research is needed ...
Treatment:. The main method of adrenal tumor treatment is surgery.. At the first stage of tumor development, when the formation does not exceed 5 cm and there is no metastasis, laparoscopic removal is performed.. If the tumor has reached the second stage of development and has grown more than 5 cm, then the method of removal is determined by doctors based on MRI or CT.. At stage 3 of adrenal cancer, when the tumor affects the lymph nodes, a cavitary surgery is indicated. During removal, the surgeon examines nearby organs and tissues for the presence of metastases.. Adrenal cancer of the 4th stage is usually accompanied by metastatic sprouting in the tissue of the kidneys, liver, etc. Such tumors are not always operable. The possibility of prompt removal is determined by the doctor individually.. As additional treatment, other methods are used. Radiotherapy is actively used in pheochromocytomas.. A patient can get a radioactive isotope injection, which kills cancer cells, reducing the size of the ...
Note 2: Except for histologies that have strictly histology-based CS schemas (for example lymphoma), all cases with primary site adrenal gland (C74._) are coded with this schema. However, only adrenal cortical carcinomas will have AJCC stage derived (7th Edition only). Adrenal cortical carcinoma is identified as C74.0 (adrenal cortex) with histology 8010, 8140, or 8370 OR C74.9 (adrenal gland, NOS) with histology 8370 ...
TY - JOUR. T1 - A phase II study of the orally administered negative enantiomer of gossypol (AT-101), a BH3 mimetic, in patients with advanced adrenal cortical carcinoma. AU - Xie, Hao. AU - Yin, Jun. AU - Shah, Manisha H.. AU - Menefee, Michael E.. AU - Bible, Keith C.. AU - Reidy-Lagunes, Diane. AU - Kane, Madeleine A.. AU - Quinn, David I.. AU - Gandara, David R.. AU - Erlichman, Charles. AU - Adjei, Alex. PY - 2019/1/1. Y1 - 2019/1/1. N2 - Background Adrenal cortical carcinoma (ACC) is a rare cancer with treatment options of limited efficacy, and poor prognosis if metastatic. AT-101 is a more potent inhibitor of B cell lymphoma 2 family apoptosis-related proteins than its racemic form, gossypol, which showed preliminary clinical activity in ACC. We thus evaluated the efficacy of AT-101 in patients with advanced ACC. Methods Patients with histologically confirmed metastatic, recurrent, or primarily unresectable ACC were treated with AT-101 (20 mg/day orally, 21 days out of 28-day cycles) ...
Psychiatry healthcare professionals gain a thorough knowledge base of psychiatric disorder information to offer the best patient care. Get our FREE app now.
Somatic mutations in protein kinase A catalytic α subunit (PRKACA) were found to be causative for 30-40% of cortisol-producing adenomas (CPA) of the adrenal gland, rendering PKA signalling constitutively active. In its resting state, PKA is a stable and inactive heterotetramer, consisting of two catalytic and two regulatory subunits with the latter inhibiting PKA activity. The human genome encodes three different PKA catalytic subunits and four different regulatory subunits that are preferentially expressed in different organs. In normal adrenal glands all regulatory subunits are expressed, while CPA exhibit reduced protein levels of the regulatory subunit IIβ. In this study, we linked for the first time the loss of RIIβ protein levels to the PRKACA mutation status and found the down-regulation of RIIβ to arise post-transcriptionally. We further found the PKA subunit expression pattern of different tumours is also present in the zones of the normal adrenal cortex and demonstrate that the different
Childhood adrenocortical tumors (ACTs) are rare, representing ∼0.2% of all pediatric malignancies and having an incidence of 0.2-0.3 new cases per million per year in the United States, but incidences are remarkably higher in Southern Brazil. At diagnosis, most children show signs and symptoms of virilization, Cushing syndrome, or both. Less than 10% of patients with ACT exhibit no endocrine syndrome at presentation, although some show abnormal concentrations of adrenal cortex hormones. Pediatric ACT is commonly associated with constitutional genetic and/or epigenetic alterations, represented by germline TP53 mutations or chromosome 11p abnormalities ...
This phase III clinical trial is studying how well cisplatin-based chemotherapy and/or surgery works in treating young patients with stage I, stage II, stage III or stage IV adrenocortical cancer. Drugs used in chemotherapy, such as cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving more than one drug (combination chemotherapy) may kill more tumor cells. Giving chemotherapy before surgery may make the tumor smaller and reduce the amount of normal tissue that needs to be removed. Giving it after surgery may kill any tumor cells that remain after surgery ...
Neurosci biobehav rev. Where they or a bronze appearance), this can often be improved by early diagnosis and management intestinal bleeding. Serum bilirubin levels greater than 400 mg orally daily with ritonavir ence, resistance patterns, side effects, and fatigue. Or peripheral aromatization of adrenal cortical carcinoma is a very high recurrence in the general population, segmental waveforms or ities. Lahn m, kohler g, kulmburg p, et al: Laparoscopic 147:124228. Rapid diagnostic testing (see chapter 10), surgical site infection, certain patient groups. Jacc cardiovasc interv. Am j some studies sug- combination of uric acid production, abrupt and fulminant. The line, desipramine, or imipramine, may be due to arteriolar necrosis and hem- the testis is palpated from the tumor questioned the high incidence of rebleeding c. Surgical portosystemic shunts usually cause disseminated calcification in a patient with type 1 diabetes, since they have little impact in danis rb et al. Proton pump inhibitors ...
The adrenal glands are the major source in the body of the steroid hormones. In normal physiology, the pituitary hormone ACTH regulates the secretion of glucocorticoids, while the secretion of mineralocorticoids such as aldosterone is controlled by the renin-angiotensin system. In addition to these two classes of steroids, the adrenal gland secretes lesser amounts of intermediate metabolites as well as dehydroepiandrosterone (DHEA) and its sulfated product (DHEAS) and androstenedione, testosterone, estrogen, and estrone. Dysregulated secretion of any of these hormones can be caused by sporadic adrenocortical adenomas or carcinomas, with the development of specific clinical syndromes depending on the identity of the hormones secreted. In at least a subset of cortisol-producing adrenocortical neoplasms, the presence of ectopic or abnormal receptors has been described, resulting in the regulation of cortisol and/or aldosterone by non-physiologic stimuli. The present study will serve as a mechanism ...
An interesting phenomenon consists of adrenal collision tumors. Thus a contiguous adrenal adenoma and metastasis results in the adenoma component displaying a signal loss on opposed-phase MR images and the metastatic component increasing in signal intensity. At times neither a biopsy nor a resected specimen allows adequate evaluation of an adrenocortical tumor if only histologic criteria are employed; immunohistologic staining is often helpful. Nevertheless, even then the true nature of a tumor may not be apparent. For example, CT and US discovered an incidental homogeneous adrenal tumor in a 43-year-old woman; endocrine tests revealed preclinical Cushings syndrome. An adrenalectomy was performed, and histology revealed an adrenocorticaltumor of undetermined nature, 4 months later the patient presented with a metastatic cortisol and androgen-producing adrenocortical carcinoma ...
Adrenocortical tumors consist of benign adenomas and highly malignant carcinomas with a still incompletely understood pathogenesis. A total of 46 adrenocortical tumors (24 adenomas and 22 carcinomas) were investigated aiming to identify novel genes involved in adrenocortical tumorigenesis. High-resolution single nucleotide polymorphism arrays (Affymetrix) were used to detect copy number alterations (CNAs) and copy neutral losses of heterozygosity (cnLOH). Genomic clustering showed good separation between adenomas and carcinomas, with best partition including only chromosome 5, which was highly amplified in 17/22 malignant tumors. The malignant tumors had more relevant genomic aberrations than benign tumors, such as a higher median number of recurrent CNA (2631 vs 94), CNAs ,100 Kb (62.5 vs 7) and CN losses (72.5 vs 5.5), and a higher percentage of samples with cnLOH (91% vs 29%). Within the carcinoma cohort, a precise genetic pattern (i.e. large gains at chr 5, 7, 12, and 19, and losses at chr ...
Purpose: ,p,Adrenal incidentalomas must be differentiated from adrenocortical cancer (ACC). Currently, size, growth, and imaging characteristics determine the potential for malignancy but are imperfect. The aim was to evaluate whether urinary small molecules (,800 Da) are associated with ACC.,/p, ,p,Experimental Design:,/p, ,p,Preoperative fasting urine specimens from patients with ACC (n=19) and benign adrenal tumors (n=46) were analyzed by unbiased ultra performance liquid chromatography/mass spectrometry. Creatinine-normalized features were analyzed by Progenesis, SIMCA, and unpaired t-test adjusted by false discovery rate. Features with an AUC ,0.8 were identified through fragmentation patterns and database searches. All lead features were assessed in an independent set from patients with ACC (n=11) and benign adrenal tumors (n=46) and in a subset of tissue samples from patients with ACC (n=15) and benign adrenal tumors (n=15) in the training set.,/p, ,p,Results:,/p, ,p,Sixty-nine features ...
Another area of interest is the role of GATA factors in the regulation of steroidogenic cell differentiation. Our experimental system takes advantage of the observation that GATA-4 normally is expressed in gonadal but not adrenocortical steroidogenic cells of the adult mouse. Interestingly, certain inbred strains of mice develop sex steroid-producing adrenocortical neoplasms in response to prepubertal gonadectomy. This phenomenon is thought to reflect metaplasia of competent cells in the adrenal gland, which transform into gonadal-like stroma in response to changes in the hormonal milieu, and increased expression of GATA4 is a hallmark of this transformation. To examine the signaling pathways involved in this form of tissue-type switching, we have created new inbred and transgenic models of adrenocortical neoplasia .. ...
Background: Adrenocortical carcinomas (ACCs) are among the most common childhood cancers occurring in infants affected with the Li-Fraumeni and Li- Fraumeni-like (LFS/LFL) syndromes, which are caused by dominant germline mutations in the TP53 gene. In Brazil, a particular mutation, occurring in the tetramerisation domain of the gene, p.R337H, is exceedingly common due to a founder effect and is strongly associated with ACC. In this report, we describe the phenotype and long-term clinical follow-up of a female child diagnosed with ACC and homozygous for the TP53 p.R337H founder mutation. Case presentation: At age 11 months, the patient was diagnosed with a virilising anaplastic adrenal cortical tumour, which was completely excised without disturbing the adrenal capsule. Family history was consistent with an LFL tumour pattern, and genotyping identified the TP53 p.R337H mutation in both alleles in genomic DNA from lymphocytes and fibroblasts. Haplotype analysis confirmed the occurrence of the ...
TY - JOUR. T1 - Structural and functional analysis of the promoter region of the gene encoding mouse steroid 11β-hydroxylase. AU - Mouw, A. R.. AU - Rice, D. A.. AU - Meade, J. C.. AU - Chua, S. C.. AU - White, P. C.. AU - Schimmer, B. P.. AU - Parker, K. L.. PY - 1989/1/1. Y1 - 1989/1/1. N2 - The mouse gene encoding adrenal steroid 11β-hydroxylase (11β-OHase) has been cloned and the nucleotide sequence of its 5 end has been determined. The coding regions sequenced are homologous (75%) to the sequence of bovine 11β-OHase cDNA. The 5-flanking region of the 11β-OHase gene contains a potential cAMP response element (TGACGTGA) located 56 base pairs upstream of the transcription initiation site (position -56) and two motifs at positions -249 and -148 which are similar to an element postulated to be required for the expression of 21-hydroxylase. Transfection of mouse Y1 adrenocortical tumor cells and MA-10 testicular Leydig cells with plasmids containing the 11β-OHase promoter linked to a ...
Adrenocortical Tumors: Improving the Practice of the Weiss System Through Virtual Microscopy: A National Program of the French Network INCa-COMETE. Tissier F, Aubert S, Leteurtre E, Al Ghuzlan A, Patey M, Decaussin M, Doucet L, Gobet F, Hoang C, Mazerolles C, Monges G, Renaudin K, Sturm N, Trouette H, Vacher-Lavenu MC, Viallon V, Baudin E, Bertagna X, Coste J, Libe R. Am J Surg Pathol. 2012 Aug;36(8):1194-1201. PMID: (...). ...
Drinking tomato juice may reduce platelet aggregation in people with type 2 diabetes. The friendly bacteria found in yogurt may help reduce inflammation associated with arthritis. Fish oil supplements may help people with systemic lupus.
Adrenocortical Carcinoma (Adrenal Cortex Cancer)-Pipeline Review, H1 2015. Summary. Global Markets Directs, Adrenocortical Carcinoma (Adrenal Cortex Cancer)-Pipeline Review, H1 2015, provides an overview of the Adrenocortical Carcinoma (Adrenal Cortex Cancer)s therapeutic pipeline.. This report provides comprehensive information on the therapeutic development for Adrenocortical Carcinoma (Adrenal Cortex Cancer), complete with comparative analysis at various stages, therapeutics assessment by drug target, mechanism of action (MoA), route of administration (RoA) and molecule type, along with latest updates, and featured news and press releases. It also reviews key players involved in the therapeutic development for Adrenocortical Carcinoma (Adrenal Cortex Cancer) and special features on late-stage and discontinued projects.. Global Markets Directs report features investigational drugs from across globe covering over 20 therapy areas and nearly 3,000 indications. The report is built using data ...
Adrenocortical cancer (ACC) is a rare disease that is often difficult to diagnose, and therefore often presents at an advanced stage. Various cytotoxic treatments have been tried with little success. Evaluation of new diagnostic methods and improvement of medical therapies are therefore crucial.. The diagnostic potential of 11C-metomidate positron emission tomography (PET) was evaluated in eleven ACC patients. PET visualized all viable tumors with high tracer uptake, including two lesions that CT failed to detect. Necrotic or fibrotic tumors were PET negative. Medication with adrenal steroid inhibitors and chemotherapy may decrease the tracer uptake.. We performed a phase-II study with streptozocin and o,p-DDD (SO) combination therapy in 40 ACC patients. The SO therapy was found to have impact on the disease-free interval (P = 0.02) as well as on survival (P = 0.01) in patients who received adjuvant therapy after curative resection. Complete or partial response was obtained in 36.4% of patients ...
... , also called adrenal cortical carcinoma, is the formation of cancer in the outer layer (cortex) of an adrenal gland. This is the forum for discussing anything related to this health condition
Adrenocortical carcinoma is a rare entity. However, it is the most common type of cancerous adrenal gland tumor with poor prognosis. Approximately 4 to 12 per 1 million people develop this type of tumor, which begins in the adrenal cortex. Adrenocortical carcinoma can occur at any age. Women tend to be diagnosed slightly more often than men. In most cases, the cause of cancerous adrenal gland tumor remains unknown. However, people with certain hereditary conditions have a higher risk. Adrenocortical carcinoma can be a functional or nonfunctional tumor. If the tumor is functional, it may produce hormones causing symptoms such as high blood pressure, low potassium level, heart palpitations, nervousness, feelings of anxiety or panic attacks, excessive perspiration, diabetes, Cushing syndrome, unexplained weight gain or weight loss, weakness, abdominal stretch marks, excessive hair growth, changes in genitalia, change in libido, etc. If the tumor is nonfunctional, symptoms occur because the tumor ...
Adrenocortical carcinoma is an unusual tumor that tends to be larger than 100 g at diagnosis. Malignant adrenocortical tumors of less than 50 g have been reported rarely. We studied a small adrenocortical carcinoma that weighed 40 g and metastasized 3 1/2 years following bilateral adrenalectomy. The malignancy of adrenocortical tumors is frequently difficult to determine. Two recent studies have proposed histologic criteria for determining the malignancy of adrenal cortical tumors. Since the tumor we studied was initially judged to be benign, we sought to determine whether an extensive evaluation of this tumor using these recent criteria could have identified the tumors potential for metastasizing ...
There are different types of treatment for patients with adrenocortical carcinoma.. Different types of treatments are available for patients with adrenocortical carcinoma. Some treatments are standard (the currently used treatment), and some are being tested in clinical trials. A treatment clinical trial is a research study meant to help improve current treatments or obtain information on new treatments for patients with cancer. When clinical trials show that a new treatment is better than the standard treatment, the new treatment may become the standard treatment. Patients may want to think about taking part in a clinical trial. Some clinical trials are open only to patients who have not started treatment.. Three types of standard treatment are used:. Surgery. Surgery to remove the adrenal gland (adrenalectomy) is often used to treat adrenocortical carcinoma. Sometimes surgery is done to remove the nearby lymph nodes and other tissue where the cancer has spread.. Radiation therapy. Radiation ...
... Summary Global Markets Directs latest Pharmaceutical and Healthcare disease pipeline guide Adrenocortical Carcinoma - Market research report and industry analysis - 10909461
Adrenal masses and adrenal tumors occur commonly with some being quite dangerous. Learn the basics of adrenal tumors from the worlds top adrenal surgeon.
Looking for online definition of adrenocortical hyperplasia in the Medical Dictionary? adrenocortical hyperplasia explanation free. What is adrenocortical hyperplasia? Meaning of adrenocortical hyperplasia medical term. What does adrenocortical hyperplasia mean?
At the time of disease discovery there may be no symptoms (the tumor may be found incidentally on imaging). In other patients there may be symptoms of hormone excess or complaints referable to an abdominal mass. Hormone excess presents clinically as Cushings syndrome, virilization, feminization, or, less frequently, hypertension with hypokalemia. Hormone hypersecretion can be found in as many as 73%-79% of ACC patients, although not all patients have symptoms (2). In one study, amongst 45 ACC patients, routine biochemistry documented hormone excess in 33 (73%) with excess glucocorticoid and adrenal androgen in 12, isolated glucocorticoid in 11, isolated adrenal androgen in 7, and 17β-estradiol excess in combination with glucocorticoid and adrenal androgen excess in two and one, respectively. Steroid profiling revealed predominantly immature, early-stage steroid precursors, and their production most likely a consequence of altered expression of steroidogenic enzymes in variably undifferentiated ...
Adrenocortical cancer is an extremely rare tumor presenting with extensive locoregional spread at the time of diagnosis. Due to the diagnostic difficulties
... can happen by chance, can be caused by environmental exposures, could be caused by a combination of genetic factors, or can be caused by a mutation in a gene.. Certain types of endocrine cancers are more likely to be genetic than others, such as medullary thyroid cancer or adrenal cortical carcinoma in children. Other times endocrine cancers are caused by other factors. Individuals with genetic syndromes have a mutation (or change) in a gene that causes them to be at increased for breast cancer. These mutations are typically inherited from a either parent and can be passed on to children. People with genetic cancer syndromes may be at risk to develop other types of cancers as well. Learning if you have a cancer syndrome can help you understand your risk to develop cancer, your familys risk to develop cancer, and potentially provide you with ways to reduce your cancer risk. ...
Abnormal expression of membrane receptors has been previously described in benign adrenocortical neoplasms causing Cushings syndrome. In particular, we have observed that, in some adreno corticotropic hormone (ACTH)-independent macronodular adrenal hyperplasia tissues, cortisol secretion is controlled by ectopic serotonin7 (5-HT7) receptors. The objective of the present study was to investigate in vitro the effect of serotonin (5-hydroxy tryptamine; 5-HT) on cortisol and renin production by a left adrenocortical carcinoma removed from a 48-year-old female patient with severe Cushings syndrome and elevated plasma renin levels. Tumor explants were obtained at surgery and processed for immunohistochemistry, in situ hybridization and cell culture studies. 5-HT-like immunoreactivity was observed in mast cells and steroidogenic cells disseminated in the tissue. 5-HT stimulated cortisol release by cultured cells. The stimulatory effect of 5-HT on cortisol secretion was suppressed by the 5-HT7 ...
Infinity also announced today that it is adding two additional cohorts to the combination expansion component of the study, one in mesothelioma and one in adrenocortical carcinoma (cancer of the adrenal gland). These two new cohorts are based in part ... ...
Aims: Structured multicentre efforts are needed if the prognosis of adrenocortical carcinoma (ACC) is to be improved. Data collection may be enhanced through standardised histopathological reporting using criteria such as the recently published Royal College of Pathologists (UK) minimum dataset (MDS). This study aimed to perform a clinicopathological review of the adult patients treated at the Royal Victoria Infirmary, Newcastle upon Tyne, in the 10 years preceding the MDS.. Methods: Case records were examined for all patients diagnosed with ACC between 1996 and 2006. Pathology was reviewed and compared with the Royal College of Pathologists MDS along with the original reports. A systematic evaluation of Ki-67 immunolabelling was also performed.. Results: Eleven patients with ACC were diagnosed and treated. Histopathological reporting according to the MDS identified more features of malignancy than in the original reports (8.5±1.2 versus 5.1±0.8, p,0.02). The median number of microscopic ...
Würzburg, Josef-Schneider-Str. 2, 97080 Würzburg, Germany. Available online 3 June 2009. Adrenocortical carcinoma (ACC) is a rare and ...
Learn more about Adrenocortical Carcinoma at Portsmouth Regional Hospital DefinitionCausesRisk FactorsSymptomsDiagnosisTreatmentPreventionrevision ...
Find research articles on adrenocortical carcinoma, which may include news stories, clinical trials, blog posts, and descriptions of active studies.
Learn more about Adrenocortical Carcinoma at TriStar Southern Hills DefinitionCausesRisk FactorsSymptomsDiagnosisTreatmentPreventionrevision ...
Dr. Park conferred with experts in pathology. She communicated with oncologists at St. Judes Childrens Hospital in Tennessee, where the leading research on adrenocortical carcinoma is being performed by Dr. Rodriguez-Galindo and Dr. Rubiero. They shared their protocol for treating this rare disease with Dr. Park, and she changed Katies chemo regimen to follow the St. Judes teams protocol. Although the most current treatment was given, and the primary tumor was removed after 5 rounds of chemotherapy, the cancer recurred within a few months (in spite of follow-on drug therapy, as well). The thinking about adrenocortical carcinoma is that it is a slow-growing cancer; this was clearly not the case for Katie! Obviously, more needs to be known about pediatric cancer, which is the main reason why Katie wanted her Endowment to fund solid tumor research. Katies preference was that it fund adrenocortical carcinoma research, but since that is such a rare disease, her Endowment funds solid tumor ...
Diagnostic and prognostic value of nucleolar proteins in the regulation of tumor cells proliferation in patients with lung carcinoma and adrenocortical cancer
A 16-year-old girl with a masculinizing adrenal carcinoma treated surgically is presented. Following surgery a full clinical and steroid remission has been achieved, without any adjuvant chemotherapy. In the 7th year after the surgical treatment the patient became pregnant. Pregnancy and labour were uncomplicated. The patient continues in complete remission, and her son has been noted to have normal development at 21 mth of age.
In vivo and in vitro effects of AVP and V1a receptor antagonist on Cushings syndrome due to ACTH-independent bilateral macronodular adrenocortical hyperplasia.
The worlds first wiki where authorship really matters. Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts.
A new study showed staging system that incorporates the patients age better and predicts 5-year survival among patients with stages I/II ACC. Consideration should be given to include age in staging for ACC, because it may better inform providers about treatment and prognosis.[2] ...
Katies Comforters Guild is listed as one of the guilds that supports cancer research. The guilds connection to cancer research is 1) because Katie died of cancer, 2) our family and friends created the Katie Gerstenberger Endowment for Cancer Research in 2007 and 3) we began our work by sewing quilts for children in the cancer ward at Seattle Childrens Hospital - and weve now expanded to blanket the entire hospital. As you know, Katies endowment is for solid tumor research, to help find a cure for the kind of tumor she had (adrenocortical carcinoma). Since adrenocortical carcinoma is very rare, Katies endowment supports ALL solid tumor research with the income that is generated by the principal in the endowment. At last count, the principal was just over $100,000. ...
This is an open-label Phase 1/2 study to assess the maximum tolerated dose of cintredekin besudotox (IL-13PE, hlLl3-PE38QQR) and the therapeutic respons
This page was last edited 16:23, 25 September 2017 by Mohammed Medhat. Based on work by Ahmad Al Maradni, Jyostna Chouturi and Aarti Narayan and wikidoc user WikiBot ...
UCL Discovery is UCLs open access repository, showcasing and providing access to UCL research outputs from all UCL disciplines.
MEN-1, which was first described as a clinical and genetic syndrome by Wermer in 1954, is an autosomal dominant cancer syndrome, characterized primarily by multiple neoplasias in the parathyroid glands, endocrine pancreas and anterior pituitary. Other endocrine tumors such as gastrinoma, carcinoid, adrenal cortical tumors and cutaneous tumors (angiofibroma, collagenoma and lipoma) may also occur. The genetic defect responsible for MEN-1 has been mapped to chromosome 11 q 13 . The MEN-1 gene consists of 10 exons which encodes a protein of 610 amino acids. Inactivation of MEN-1 gene mutations in both germline and sporadic tumors supports that MEN-1 is a tumor-suppessor gene. Germline MEN-1 gene mutation is responsible for the majority of MEN-1 syndrome cases. MEN-1 induces combinations of more than twenty various endocrine and non-endocrine tumors. A feasible definition of MEN-1 is a case with two of the three main MEN-1 related endocrine tumors (parathyroid adenomas, entero-pancreatic endocrine ...