Expression of bone morphogenetic protein 4 (BMP4) in adipocytes of white adipose tissue (WAT) produces white adipocytes with characteristics of brown fat and leads to a reduction of adiposity and its metabolic complications. Although BMP4 is known to induce commitment of pluripotent stem cells to the adipocyte lineage by producing cells that possess the characteristics of preadipocytes, its effects on the mature white adipocyte phenotype and function were unknown. Forced expression of a BMP4 transgene in white adipocytes of mice gives rise to reduced WAT mass and white adipocyte size along with an increased number of a white adipocyte cell types with brown adipocyte characteristics comparable to those of beige or brite adipocytes. These changes correlate closely with increased energy expenditure, improved insulin sensitivity, and protection against diet-induced obesity and diabetes. Conversely, BMP4-deficient mice exhibit enlarged white adipocyte morphology and impaired insulin sensitivity. We ...

TY - JOUR. T1 - Myogenic gene expression signature establishes that brown and white adipocytes originate from distinct cell lineages. AU - Timmons, James A.. AU - Wennmalm, Kristian. AU - Larsson, Ola. AU - Walden, Tomas B.. AU - Lassmann, Timo. AU - Petrovic, Natasa. AU - Hamilton, D. Lee. AU - Gimeno, Ruth E.. AU - Wahlestedt, Claes. AU - Baar, Keith. AU - Nedergaard, Jan. AU - Cannon, Barbara. PY - 2007/3/13. Y1 - 2007/3/13. N2 - Attainment of a brown adipocyte cell phenotype in white adipocytes, with their abundant mitochondria and increased energy expenditure potential, is a legitimate strategy for combating obesity. The unique transcriptional regulators of the primary brown adipocyte phenotype are unknown, limiting our ability to promote brown adipogenesis over white. In the present work, we used microarray analysis strategies to study primary preadipocytes, and we made the striking discovery that brown preadipocytes demonstrate a myogenic transcriptional signature, whereas both brown and ...

In our studies, we initially focused on protein kinase G (PKG/cGK), which is expressed both in white and brown adipocytes. Using gain- and loss-of-function models, we found that PKG is the major receptor for cGMP in brown adipocytes. We investigated the downstream targets of PKG and found a novel negative feedback loop that regulates cGMP levels. Importantly, in the presence of increased cGMP levels, we found an enhanced development of brown-like adipocytes, so-called beige or brite (brown in white) cells both in vitro and in vivo. These data indicate that cGMP not only enhances development of classical brown adipocytes, but also promotes development of beige cells.. Therefore, we studied the effect of cGMP in white adipocytes in more detail. Lentiviral overexpression of PKG enhanced differentiation of white adipocytes. Moreover, PKG induced the expression of a brown-like adipogenic program in white fat cells. Treatment of mice with the PDE inhibitor sildenafil for only 7 days promoted ...

Abstract / summary in English: Background: The uncoupling protein 1 (UCP1) is a hallmark of brown adipocytes and pivotal for cold- and diet-induced thermogenesis.. Methodology/Principal Findings: Here we report that cyclooxygenase (COX) activity and prostaglandin E2 (PGE2) are crucially involved in induction of UCP1 expression in inguinal white adipocytes, but not in classic interscapular brown adipocytes. Cold-induced expression of UCP1 in inguinal white adipocytes was repressed in COX2 knockout (KO) mice and by administration of the COX inhibitor indomethacin in wild-type mice. Indomethacin repressed b-adrenergic induction of UCP1 expression in primary inguinal adipocytes. The use of PGE2 receptor antagonists implicated EP4 as a main PGE2 receptor, and injection of the stable PGE2 analog (EP3/4 agonist) 16,16 dm PGE2 induced UCP1 expression in inguinal white adipose tissue. Inhibition of COX activity attenuated diet-induced UCP1 expression and increased energy efficiency and adipose tissue ...

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Information on Middlesex University's Research Repository: a online collection of Middlesex University's research outputs

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KEGG Orthology (KO) [BR:dwi00001] 09120 Genetic Information Processing 09121 Transcription 03040 Spliceosome [PATH:dwi03040] 6647329 heat shock 70 kDa protein cognate 4 K03283 HSPA1s; heat shock 70kDa protein 1/2/6/8 09123 Folding, sorting and degradation 04141 Protein processing in endoplasmic reticulum [PATH:dwi04141] 6647329 heat shock 70 kDa protein cognate 4 K03283 HSPA1s; heat shock 70kDa protein 1/2/6/8 09140 Cellular Processes 09141 Transport and catabolism 04144 Endocytosis [PATH:dwi04144] 6647329 heat shock 70 kDa protein cognate 4 K03283 HSPA1s; heat shock 70kDa protein 1/2/6/8 09150 Organismal Systems 09149 Aging 04213 Longevity regulating pathway - multiple species [PATH:dwi04213] 6647329 heat shock 70 kDa protein cognate 4 K03283 HSPA1s; heat shock 70kDa protein 1/2/6/8 09180 Brite Hierarchies 09181 Protein families: metabolism 01009 Protein phosphatases and associated proteins [BR:dwi01009] 6647329 heat shock 70 kDa protein cognate 4 K03283 HSPA1s; heat shock 70kDa protein 1/2/6/8 ...

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Much of the current excitement in the obesity field stems from recent observations highlighting that, even as adults, we have the ability to generate brown fat cells in response to cold exposure. Unlike white fat cells that mostly just store fat, brown adipocytes keep us warm by burning fat at a high rate, said Dr. Philipp Scherer, Director of the Touchstone Center for Diabetes Research at UT Southwestern and senior author of the study available online at Nature Medicine.. While generation of brown fat cells previously was thought to be mostly relevant for rodents and human infants, Dr. Scherer said, current evidence points to the observation that adults also generate these cells when exposed to cold.. Brown fat cells in adults tend to be randomly interspersed in subcutaneous white fat, with a trend toward increased accumulation in the upper chest and neck areas. In general, brown fat tissue makes up just a small percentage of total body fat mass.. The Touchstone Centers staff devotes its ...

In contrast to β1- and β2-ARs, the β3-AR induces a decrease in cardiac contractility in different species, including human, dog, guinea pig, and rat (Gauthier et al., 1999; Kitamura et al., 2000; Cheng et al., 2001; Morimoto et al., 2004). A coupling of β3-ARs to Gi/o protein and the activation of endothelial nitric-oxide synthase mediate this negative inotropic effect (Gauthier et al., 1998; Kitamura et al., 2000; Varghese et al., 2000; Brixius et al., 2004). Therefore, the modulation of cardiac contractility by the β3-ARs seems to involve the inhibition of the adenylyl cyclase and the decreased in intracellular cAMP content. In contrast, this subtype controls lipolysis in rat white adipocytes (Van Liefde et al., 1992; Germack et al., 1997) and thermogenesis in brown adipocytes (Atgie et al., 1997) through Gs protein activation. However, a dual coupling of the β3-ARs to Gs and Gi has been reported in white adipocytes (Chaudhry et al., 1994) and 3T3-F442A adipocytes (Soeder et al., 1999). ...

Yale scientists uncover how a molecular process in the brain that known to control eating transforms white fat into brown fat, impacting how much energy we burn and how much weight we can lose.. The results are published in the October 9 issue of the journal Cell.. Obesity is a rising global epidemic. Excess fatty tissue is a major risk factor for type 2 diabetes, cardiovascular disease, hypertension, neurological disorders, and cancer. People become overweight and obese when energy intake exceeds energy expenditure, and excess calories are stored in the adipose tissues. The adipose organ is made up of both white and brown fat. While white fat primarily stores energy as triglycerides, brown fat dissipates chemical energy as heat. The more brown fat you have, the more weight you can lose.. It has previously been shown that energy-storing white fat has the capacity to transform into energy-burning brown-like fat. In this new study, researchers from the Yale Program in Integrative Cell Signaling ...

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Shiny Brite ornaments were created by American businessman Max Eckardt in 1937. Before World War II, almost all of the glass ornaments on American Christmas trees were imported from Germany. It was a German immigrant, Max Eckardt, who realized that the war could interrupt his Christmas ornament import business. So in 1937, Eckardt and Bill…

To overcome the side effects of current anti-obesity drugs, researchers Jee Young Chung and colleagues developed a specific gene silencing therapy against a fatty acid metabolism gene, Fabp4. Researchers used a CRISPR interference system wherein catalytically dead Cas9 protein and single guide RNA was targeted to white adipocytes with a tissue-specific fusion peptide. The complex is internalized with little toxicity to the cells and, upon internalization, decreased the expression of Fabp4 and reduced lipid storage in adipocytes. Demonstrating that this delivery method performed well in cells, Chung and colleagues tested their therapy on obese mice. Mice were fed a diet high in fat leading to obesity and insulin resistance. Fabp4 repression resulted in a 20% reduction of body weight and improved insulin resistance and inflammation after just six weeks of treatment. Additional systemic improvements were observed, including a reduction in fatty lipid deposition in the liver and reduced circulating ...

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PGC-1α-dependent irisin, a novel myokine, is derived from cleaving Fndc5 protein. Irisin promotes brown fat-like development and thermogenesis in WAT both in vitro and in vivo. The discovery of irisin has created an opportunity to further understand the role of adipocytes in obesity, diabetes, and other associated metabolic disorders (12,13,26,27). However, the molecular mechanisms and cellular signaling pathways responsible for the browning effect of irisin have not been elucidated.. In this study, we successfully constructed the yeast expression plasmid containing a synthesized optimal codon usage, human irisin-coding sequence and generated pure human recombinant irisin protein in P. pastoris with high yield that is fully biologically functional. The P. pastoris system is widely used for heterogenic protein expression, with the capacity to generate posttranslational modified proteins (28). The human recombinant irisin protein expressed in yeast showed a predominant band of ∼22 kDa, which is ...

The presence of two distinct types of adipose tissue, which have opposing functions, has been known for decades. White adipose tissue (WAT) is the main tissue of energy storage, while brown adipose tissue (BAT) dissipates energy as heat and is required for non-shivering thermoregulation. In the last few years, a third type of adipocyte was identified, termed the brite (brown and white) or beige adipocyte. Their physiological control and role, however, are not fully clarified. Brite/beige adipocytes have a positive impact on systemic metabolism that is generally explained by the thermogenesis of brite/beige adipocytes; although thermogenesis has not been directly measured but is mostly inferred by gene expression data of typical thermogenic genes such as uncoupling protein 1 (UCP1). Here we critically review functional evidence for the thermogenic potential of brite/beige adipocytes, leading to the conclusion that direct measurements of brite/beige adipocyte bioenergetics, beyond gene ...

Induction of brown-like adipocytes (beige/brite cells) in white adipose tissue (WAT) suggests a new approach for preventing and treating obesity via induction of thermogenesis associated with uncoupling protein 1 (UCP1). However, whether diet-derived factors can directly induce browning of white adipocytes has not been well established. In addition, the underlying mechanism of induction of brown-like adipocytes by diet-derived factors has been unclear. Here, we demonstrate that artepillin C (ArtC), which is a typical Brazilian propolis-derived component, significantly induces brown-like adipocytes in murine C3H10T1/2 cells and primary inguinal WAT (iWAT)-derived adipocytes. This significant induction is due to activation of peroxisome proliferator-activated receptor γ and stabilization of PRD1-BF-1-RIZ1 homologous domain-containing protein-16 (PRDM16). Furthermore, the oral administration of ArtC (10 mg/kg) for 4 weeks significantly induced brown-like adipocytes accompanied by significant ...

We also shine a spotlight on governance and social responsibility in this edition. Grant Thornton UK explains why good governance is the surprise element in creating a culture that sparks new ideas, and Impact Reporting tells us how its technology is helping organisations to improve their social value reporting.. Also in this edition, we hear from SAS how data analytics can be used for the greater good in the public sector, find out how organisations can create a culture of innovation through learning and development, and take a look at selected video highlights from the UNs third AI for Good Summit in Geneva.. I hope you enjoy this edition of Brite Innovation Review.. Susanne Hauner, Publisher. We always welcome views on innovation from across industry, government and academia. If youd like to contribute an article to Brite, dont hesitate to get in touch.. ...

Dermal adipose tissue (also known as dermal white adipose tissue and herein referred to as dWAT) has been the focus of much discussion in recent years. However, dWAT remains poorly characterized. The fate of the mature dermal adipocytes and the origin of the rapidly reappearing dermal adipocytes at different stages remain unclear. Here, we isolated dermal adipocytes and characterized dermal fat at the cellular and molecular level. Together with dWATs dynamic responses to external stimuli, we established that dermal adipocytes are a distinct class of white adipocytes with high plasticity. By combining pulse-chase lineage tracing and single-cell RNA sequencing, we observed that mature dermal adipocytes undergo dedifferentiation and redifferentiation under physiological and pathophysiological conditions. Upon various challenges, the dedifferentiated cells proliferate and redifferentiate into adipocytes. In addition, manipulation of dWAT highlighted an important role for mature dermal adipocytes ...

KEGG Orthology (KO) [BR:adk00001] 09100 Metabolism 09106 Metabolism of other amino acids 00480 Glutathione metabolism [PATH:adk00480] Alide2_0050 Glutathione S-transferase domain protein K00799 GST; glutathione S-transferase [EC:2.5.1.18] 09180 Brite Hierarchies 09183 Protein families: signaling and cellular processes 02000 Transporters [BR:adk02000] Alide2_0050 Glutathione S-transferase domain protein K00799 GST; glutathione S-transferase [EC:2.5.1.18] Enzymes [BR:adk01000] 2. Transferases 2.5 Transferring alkyl or aryl groups, other than methyl groups 2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date) 2.5.1.18 glutathione transferase Alide2_0050 Glutathione S-transferase domain protein K00799 GST; glutathione S-transferase [EC:2.5.1.18] Transporters [BR:adk02000] Other transporters Pores ion channels [TC:1] Alide2_0050 Glutathione S-transferase domain protein K00799 GST; glutathione S-transferase [EC:2.5.1.18 ...

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Spiritual guidance Pastoral care transcends traditional counseling.. By Rachel Stowe Master 91. Nine months after she lost her 18-year-old daughter in a 2003 boating accident, Denise Brookman knew she needed help. It had been just three years since her other child - a son - had died, also at age 18. Heartbroken and devastated, Denise needed help working through overwhelming grief. She found it when a friend suggested she contact Brite Divinitys Pastoral Care and Training Center.. Its by the grace of God that everything has come about, Brookman said. Brite Divinity School helped me a lot.. She met three times with a young pastor from an area Church of Christ who was working on his graduate education at Brite. He had such an open heart about it. The level that [Brite counselors] are able to talk to you is different than a psychiatrist, a psychologist, your friends, your wonderful family. I think its very good to be able to talk to someone who is not on a level thats just medical. Because ...

abstract = {Over 1 billion people are estimated to be overweight, placing them at risk for diabetes, cardiovascular disease, and cancer. We performed a systems-level genetic dissection of adiposity regulation using genome-wide RNAi screening in adult Drosophila. As a follow-up, the resulting approximately 500 candidate obesity genes were functionally classified using muscle-, oenocyte-, fat-body-, and neuronal-specific knockdown in vivo and revealed hedgehog signaling as the top-scoring fat-body-specific pathway. To extrapolate these findings into mammals, we generated fat-specific hedgehog-activation mutant mice. Intriguingly, these mice displayed near total loss of white, but not brown, fat compartments. Mechanistically, activation of hedgehog signaling irreversibly blocked differentiation of white adipocytes through direct, coordinate modulation of early adipogenic factors. These findings identify a role for hedgehog signaling in white/brown adipocyte determination and link in vivo RNAi-based ...

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Disclosure: The reviewer has been compensated in the form of a Best Buy Gift Card and/or received the product/service at a reduced price or for free.. The last year has been pretty difficult for me as I am working on being a single mom. Each day seems to be a challenge. Ive been pretty overwhelmed and stressed out with many other things going on in our lives.. This month, my son and I start a new chapter in our lives. I recently closed on my first home as a single mom and we just moved in! We are starting fresh! It was very difficult to pack and organize all on my own. I was lucky enough to have help from my boyfriend with moving everything!. … [read more] ...

This website uses cookies to improve your experience while you navigate through the website. Out of these, the cookies that are categorized as necessary are stored on your browser as they are essential for the working of basic functionalities of the website. We also use third-party cookies that help us analyze and understand how you use this website. These cookies will be stored in your browser only with your consent. You also have the option to opt-out of these cookies. But opting out of some of these cookies may affect your browsing experience ...

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You dont understand what I saying. Most the 1980s toon were made for just the reason of promoting toys. There was no entertainnmnet value at all for alot of 1980s toon. Might Mouse was very rare exeception, it actually had enterainment value. Shows like He-man and Rainbow Brite were only made to push toys, they were produced my mattel. This still goes on today, Batman Beyound was only made push toys for the WB, Paul Dini himself said this. ...

You dont understand what I saying. Most the 1980s toon were made for just the reason of promoting toys. There was no entertainnmnet value at all for alot of 1980s toon. Might Mouse was very rare exeception, it actually had enterainment value. Shows like He-man and Rainbow Brite were only made to push toys, they were produced my mattel. This still goes on today, Batman Beyound was only made push toys for the WB, Paul Dini himself said this. ...