Methods and compositions are provided for enhancing the bioadhesive properties of polymers used in drug delivery devices. The bioadhesive properties of a polymer are enhanced by incorporating a anhydrideoligome into the polymer to enhance the ability of the polymer to adhere to a tissue surface such as a mucosal membrane. Anhydrideoligomes which enhance the bioadhesive properties of a polymer include water-insoluble anhydrideoligomes such as water-insoluble metal oxides, including oxides of calcium, iron, copper and zinc. The anhydrideoligomes can be incorporated within a wide range of polymers including proteins, polysaccharides and synthetic biocompatible polymers. In one embodiment, metal oxides can be incorporated within polymers used to form or coat drug delivery devices, such as microspheres, which contain a drug or diagnostic agent. The metal oxides can be provided in the form of a fine dispersion of particles on the surface of a polymer that coats or forms the devices, which enhances the ability
The remarkable underwater adhesion strategy employed by mussels has inspired bioadhesives that have demonstrated promise in connective tissue repair, wound closure, and local delivery of therapeutic cells and drugs. While the pH of oxygenated blood and internal tissues is typically around 7.4, skin and tumor tissues are significantly more acidic. Additionally, blood loss during surgery and ischemia can lead to dysoxia, which lowers pH levels of internal tissues and organs. Using 4-armed PEG end-capped with dopamine (PEG-D) as a model adhesive polymer, the effect of pH on the rate of intermolecular cross-linking and adhesion to biological substrates of catechol-containing adhesives was determined. Adhesive formulated at an acidic pH (pH 5.7-6.7) demonstrated reduced curing rate, mechanical properties and adhesive performance to pericardium tissues. Although a faster curing rate was observed at pH 8, these adhesives also demonstrated reduced mechanical and bioadhesive properties when compared to ...
All information about the latest scientific publications of the Clínica Universidad de Navarra. Bioadhesive properties and biodistribution of cyclodextrin-poly(anhydride) nanoparticles
Tissue engineering is a multidisciplinary field that aims to repair or regenerate lost or damaged tissues and organs in the body. For the repair of certain load-bearing parts of the body, success of a tissue regeneration strategy can be dependent on scaffold adhesion or integration with the surrounding host tissue to prevent dislocation. One such area is the regeneration of the intervertebral disc (IVD). The objective of this work is to generate a bioadhesive polymer that, in addition to bonding with tissue, can support encapsulated cell survival post-adhesion. Thermosensitive poly(N-isopropylacrylamide) (PNIPAAm) was grafted with chondroitin sulfate (CS) (PNIPAAm-g-CS) and blended with aldehyde-modified CS to achieve covalent adhesion upon contact with tissue. Extracellular matrix (ECM) loaded lipid vesicles (liposomes) were incorporated into the copolymer for enhanced cellular biocompatibility. The bioadhesive strength was evaluated in contact with porcine ear cartilage. Additionally, the cytotoxicity
We found no difference in the adhesive force or the motion of clinging digits between before and after death treatments (figure 2b,f). Although previous research and anecdotes have shown that some adhesion can still occur after death in geckos [15-17], our controlled experiments are the first to show that dead animals maintain the ability to adhere with the same force as living animals. These results refute the hypothesis that actions by a living animal, such as muscle recruitment or neural activity, are required for gecko feet to generate our high measured forces.. The high variation in adhesive force among trials on both living and dead geckos is surprising. Despite the controlled pulling force applied by our pulling device, peak adhesive force spanned a range that was 19.9 times the mean body weight. When averaged among individuals, the mean coefficients of variation for adhesive force before and after death were 0.33 and 0.36, respectively. After pooling alive and dead trials, a multiple ...
Cohesive and adhesive forces are associated with bulk (or macroscopic) properties and hence the terms are not applicable to discussion of atomic and molecular properties. When a liquid comes into …
5x4.5Window Clings are made from a special paint that acts like static that clings to your window. These amazing clings are so darn cute that youll f
The science on display is the capillary action of the water - that is, how the flower drinks even without its roots. This ability draws water against the force of gravity up the stem and into the petals. It works because the water evaporating from the petals and leaves of the plant "pulls" water up the narrow tubes in the stem (the xylem) to replace that which is lost. The tubes need to be narrow so that the combination of the surface tension of the water (caused by cohesion in the water - how well it sticks to itself) and the adhesive forces between the water and the walls of the xylem are strong enough to lift the water against the force of gravity. The adhesive forces are proportional to the diameter of the tube, whilst the weight of the water is proportional to this diameter squared - hence a smaller diameter favours the adhesive forces ...
How to Make Window Clings. Window clings are a fun way to decorate your windows for the holidays and other occasions. They are easy to peel off, rearrange, and replace. Unfortunately, store-bought ones dont come in a lot of designs, and...
Flow Range: 50 - 2,400 U.S. GPM (11 - 545 m³/hr). The LAKOS Self-Cleaning PC Screen offers continuous pump protection without the worry of routine maintenance. The internal backwash system blows debris off and away from the screen, allowing water to flow freely to the pump intake. The entire screen rotates so that debris is blown away. Better than stationary screens, which waste time and energy due to repeated clogging. Save energy, end routine maintenance, and protect the environment with LAKOS PC Self-Cleaning Pump Intake Screens.. Fish-Safe Applications ...
...Let us also lay aside every weight, and sin which clings so closely, and let us run with endurance the race that is set before us, looking to Jesus, the founder and perfecter of our faith... Hebrews 12:1b-2a
Taxonomic Characterization: A minute diaphanous anchialine cyclopoid. The genus Speleoithona is distinguished from other cyclopoids by several characteristics. The rostrum is enlarged and notched medially. The inner apical seta on the caudal rami is absent. The mandible has a smooth and quadrangular basal segment 2, and a 2-segmented endopodite with an unarmed proximal segment and 3 setae on the terminal segment. The antennule is 18-segmented, with aesthetascs on segments 8,17, and 18. On the second through fourth legs, the endopodite 3 has a row of pinnules on the caudal face. The fifth legs are 2-segmented, bear long seta, and are joined by an intercoxal plate. In males, the fifth legs also have 2 short setae on the inner side of the distal segment. S. salvadorensis can be distinguished from other Speleoithona by the following characteristics ...
Some people love washing their cars, but many folks would appreciate having the fresh-from-the-showroom look without all of the effort. And dont forget the environmental impact of car washing, which drains water reserves and spills pollutants into endangered wetlands. If only our cars would clean themselves.. Thanks to some researchers at the Eindhoven University of Technology in the Netherlands, we may be closer to a perpetually polished Prius. The scientists didnt invent a brand-new nanotechnology. Instead, they took an existing water-resistant product, already in use on some vehicles, and made it better. The original coating worked because it came embedded with nanocapsules in its surface. Those tiny capsules both repelled water and contained cleaning agents or paint droplets so that when they were ruptured, say by a key scratch, they released their contents and healed the blemish. Unfortunately, the capsules had a limited shelf life. To extend the self-cleaning/healing properties of the ...
Synonyms for adhesiveness in Free Thesaurus. Antonyms for adhesiveness. 3 synonyms for adhesiveness: adherence, adhesion, bond. What are synonyms for adhesiveness?
A self-cleaning electric oven uses intense heat to burn away food residue, often heating to more than 900 degrees Fahrenheit. The process requires several hours to complete and cool down, and it can...
M. B. Avinash, E. Verheggen, C. Schmuck and T. Govindaraju, Self-cleaning Functional Molecular Materials, Angew. Chem., 124, 10470-10474 ( 2012);, Angew. Chem. Int. Ed 51, 10324 - 10328 (2012). , (Chosen as a Hot Paper by the Editors for its importance in a rapidly evolving field of high current interest). Highlighted in ChemistryViews: Self-Assembling and Self-Cleaning. Microarrays of a naphthalenediimide derivative can be used to fabricate self-cleaning surfaces ...
Only the Sigillite can save Revuel Arvidas body, and only his primarch can save his soul.[1] His body ravaged by the flesh-change, Thousand Sons sorcerer Revuel Arvida clings to life by the merest thread. And even if Malcador the Sigillite can save him, what will remain?[1] The Thousand Sons sorcerer Revuel Arvida guided his White Scars kinsmen through all the horrors of the ruinstorm, even though the psychic exertion almost killed him. Now on Terra, he clings to life by the merest thread, his body ravaged by the curse of his Legion - the insidious flesh-change. The primarch Jaghatai Khan demands that Arvida be saved, no matter the cost. But even if such a thing were possible, what would remain of his mind and soul?[1] ...
Diminishing career... what to do?... film flops... badly... people laughing in the streets... Madonnas escape plan: guest role in Will & Grace... surely not testing the ground for Maddie, a sitcom where she plays a former rock star juggling her career and family? ...
|p style=text-align: center;||span style=font-size: medium; color: #005298;||strong|Betco Kling Toilet Bowl Cleaner does just what the name implies—it clings to toilet bowl surfaces, providing more contact time to allow the product to remove rus
I finally roasted some of the Anaheim chilis and jalapeños last night. If you havent roasted peppers, you should try it. Not only is it an easy way to cook them but after you throw them in a bowl and cover it with cling film/plastic wrap, they peel very easily. Right now were eating them…
He wants to stick to them just like an afraid child clings to his mother. Pathetic, I know. But if was it ever so easy to make this stupid heart understand, I wouldve done the job already. It just wont listen to me anymore
Public News Sites, Mainstream Media ia and behavioral thoughts. While we are to cling the DaysCancel of this d, we cannot be that it lets Now financial. Beyond this, we re now interest again to its g for any F.
I knew the second I saw this scene that this would be my main pic tonight. JY might not realize it yet, but he didnt mean to lose his grip on sanity - he was actually trying to cling to his better half. The side of him that he has nurtured, encouraged, and cheered on these past three years. KW has become more…
As amazing and breathtaking as the worlds oceans may be, theyre even more mysterious and sometimes cling unyieldingly to their secrets and mysteries.
If youre someone who always keeps a backup on the bench while youre dating, read this. A relationships coach gets real about why we cling to backups.
Powerful 48-hour hydration in a lightweight serum suitable for all skin types, including combination. Ultra-light texture softens and deeply comforts skin all day, without stickiness or oiliness.
We dont know much about the genetic evolution of the human brain. Now experiments suggest genes involved in cell stickiness may have given our brain its folds
Techniques Cell culture WiDr cell lines have MAP キナーゼ 阻害剤 been obtained in the American Variety Culture Collection, and had been cultured in accordance to your
Van der Waals forces: Van der Waals forces, relatively weak electric forces that attract neutral molecules to one another in gases, in liquefied and solidified gases, and in almost all organic liquids and solids. The forces are named for the Dutch physicist Johannes Diderik van der Waals, who in 1873 first postulated
Downloadable! To investigate the banking sector integration across euro area countries in terms of loan interest rate stickiness, we estimate structural loan rate curves for 12 euro area countries using time-varying regressions with stochastic volatility. Our results show that the loan rates are sticky to a policy interest rate in all countries for all loan maturities, the degree of stickiness differs across the countries, and the degree of difference is more prominent for longer loan maturities. For short-term loans, the loan rate stickiness decreases and for intermediate- and long-term loans the loan rate stickiness converge to average levels during the sample periods. Banking integration in the euro area is not yet complete, but the degree of heterogeneity in the loan rate stickiness decreases.
Article Modeling study of the effects of the coagulation kernel with van der Waals forces and turbulence on the particle size distribution. In this study, variations in the size distributions due to different assumptions for the coagulation kernel ar...
Specialized tarsal setae with an attachment function have evolved independently several times among arthropods (Gorb and Beutel, 2001). They enable effective, dynamic attachment to various surfaces during locomotion. In hairy adhesive pads, the adhesive performance is enhanced by multiple contact sites (Jagota and Bennison, 2002), a high compliance of setae (Persson, 2003) and terminal contact elements (Persson and Gorb, 2003), and a hierarchical organization (Kim and Bushan, 2007; Gasparetto et al., 2009). Adhesion enhancement due to multiple contacts can be explained by the involvement of various effects, such as crack propagation prevention (Chung and Chaudhury, 2005) and surface roughness compatibility (Peressadko and Gorb, 2004a; Bhushan et al., 2006).. Under natural conditions, animals attach to unpredictable surfaces of very different roughness, which normally reduces adhesion even in the hairy attachment devices of geckos and insects. In previous work, it has been shown that there is a ...
The ability to climb is a significant advantage for animals, as it makes available habitats not accessible to non-climbers or non-flyers. Indeed, many animal phyla and groups are represented in arboreal habitats. These animals are characterised by mechanisms that facilitate climbing and reduce the risk of falling. On rough surfaces, friction pads and claws can be effective, but on smooth surfaces and significant overhangs, some mechanism of adhesion is essential (Peattie, 2009). Adhesion allows an organism to remain attached to an inclined, vertical or even an upside down surface whilst resisting falling or slipping. Animals have evolved two different mechanisms for adhesion - dry and wet. Dry adhesion, typified by geckos, involves toe pads covered in very large numbers of finely branching setae, each ending in a flattened spatula. These spatulae make such close contact with the surface that van der Waals forces, which hold molecules together in solids, form the adhesive bonds (Autumn et al., ...
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... A description of the different factors affecting the hydraulic design of self-cleaning sewage tunnels with a free water surface is presented. It is found that the two most important problems involved are related to shear stress distribution and critical shear stress to secure self-cleaning. Based on a shear stress distribution normally assumed for open channels, a trapezoidal bottom shape is suggested. A value for critical shear stress to prevent settlement of sand in a mixture of wastewater is recommended, but design data are also included for alternative values of critical shear stress. Curves for determining shape, slope, and size of tunnels with known minimum and maximum rate of flow are given.
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In figure 1, a nanoparticle is shown dispersed in a liquid, which also contains surface active molecules (adhesion molecules). The particle diffuses towards the cell surface, makes contact and then wanders around the local area. It may find a point of entry or it may dislodge and continue its Brownian exploration of the fluid [4]. This process is similar to that involved in a virus infecting lung cells. A paper in this volume shows that the presence of nanoparticles can influence the progress of influenza virus infection [5].. To start this volume, we describe van der Waals force which is the source of adhesion in geckos that run up walls and under ceilings without any adhesive [6]. Next, by considering adhesion of ants feet under water [7], it becomes clear that the presence of a liquid has a large influence on van der Waals adhesion, decreasing the adhesion force by an order of magnitude. However, there is also the confusing effect that liquids may hugely increase the contact area, which may ...
What makes kitchen plastic wrap cling so maddeningly to itself, and so conveniently to the sides of bowls and plates? Learn more on this Moment of Science.
Find the outdoor temperature from inside. Outdoor Easy to Read Windowpane Thermometer by KleerTemp. Clings electrostatically. Large, readable numbers in full view. No tools needed. 7.25 Diameter. One year warranty. No batteries or power needed. Reads both Fahrenheit and Centigrade.
Looking for LYLE Electrical Hazard, Caution, Polyester, 7 x 10, Adhesive Surface, Not Retroreflective (455Z92)? Graingers got your back. Price $6.37. Easy online ordering and next-day delivery available with 24/7 expert product support.
The Samsung 5.9 cu. ft. Electric Range with Self-Cleaning in Stainless Steel is convenient to clean. It comes with four smooth top elements to offer a variety of cooking options. It is a perfect place for storing pots and pans.
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Question - What causes itchiness and stickiness around testicles and scrotum ?. Ask a Doctor about uses, dosages and side-effects of Lotrimin, Ask an Internal Medicine Specialist
Sample preparation: The samples were placed in specially designed sample cuvettes, which exposed a flat circular surface with a diameter of 5 cm for measurement. Samples were placed in the cuvettes such that the interior of the fillets was exposed for autofluorescence measurements. Before measurements, the samples were conditioned at 18°C for at least one hour.. Fluorescence spectroscopy: The samples were excited with a 332 nm interference filter where after the emission was measured from 360 to 600 nm. Two spectra were collected and the average was used for further analysis.. Texture: Texture was evaluated instrumentally by compression using a Texture Analyzer TA.XT2 equipped with a cylindrical plunger. The plunger was pressed into the fillets at a constant rate of 1 mm-1 until it reached 90 % of the sample height. The resistance force was recorded at the maximum force obtained during compression. Two measurements were performed on each fillet, and the mean value was used for the analysis. The ...
Texture analyzer fixtures manipulate the forces applied to the test sample, to accurately replicate the conditions of a consumer interacting with the product.
CEREAL PRODUCTS TESTING ATTACHMENTS FOR CEREAL PRODUCTS Any of the Stable Micro Systems Texture Analyser range may be used for testing the products listed
An acid used for medicine and to flavor some drinks soon may help make electronic components and certain adhesives more durable and better for the environment.
Kaolinit Smektit / Vermiculit Illit (fine-grained micas) Kelas Umum 1:1 (TetraOcta) 2:1 (TOT) Pengembangan Ikatan lapisan ionic , H-bonding , van der Waals Muatan negatif neto (KTK) Fertility Lokasi muatan Low Low, none High/Moderate Hydrogen (strong) O-O & O-Cation van der Waals (weak) Potassium ions (strong) "the name van der Waals force is sometimes used as a synonym for the totality of non-covalent forces (also known as intermolecular forces). These forces, which act between stable molecules, are weak compared to those appearing in chemical bonding. To explain this, we refer to the article on intermolecular forces, where it is discussed that an intermolecular force has four major contributions. In general an intermolecular potential has a repulsive part, prohibiting the collapse of molecular complexes, and an attractive part. The attractive part, in turn, consists of three distinct contributions (i) The electrostatic interactions between charges (in the case of molecular ions), dipoles ...