Adenylosuccinate lyase is an enzyme of fumarase superfamily that participates in the purine biosynthetic pathway, catalysing the nonhydrolytic cleavage of succinyl groups from SAICA ribotide and adenylosuccinate. Enzyme defects are associated with a

2VD6: Human adenylosuccinate lyase in complex with its substrate N6-(1,2- Dicarboxyethyl)-AMP, and its products AMP and fumarate.

SWISS-MODEL Repository entry for A8Q0E3 (PURA_MALGO), Adenylosuccinate synthetase. Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)(Dandruff-associated fungus)

p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.,/p> ,p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.,/p> ,p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).,/p> ,p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x,sup>64,/sup> + x,sup>4,/sup> + x,sup>3,/sup> + x + 1. The algorithm is described in the ISO 3309 standard. ,/p> ,p class=publication>Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.,br /> ,strong>Cyclic redundancy and other checksums,/strong>,br /> ,a href=http://www.nrbook.com/b/bookcpdf.php>Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993),/a>),/p> Checksum:i ...

1CGY: SITE DIRECTED MUTATIONS OF THE ACTIVE SITE RESIDUE TYROSINE 195 OF CYCLODEXTRIN GLYXOSYLTRANSFERASE FROM BACILLUS CIRCULANS STRAIN 251 AFFECTING ACTIVITY AND PRODUCT SPECIFICITY

Spontaneous mutants arise among nondividing populations of Escherichia coli in apparent response to selective conditions. In this report we investigate several hypotheses to account for the role of selection in the production of these directed or adaptive mutations. We found that the Lac+ phenotypes of some mutants that arise late after lactose selection are due to suppressor mutations that are unlinked to the mutant lacZ allele; thus the production of these Lac+ mutants does not require an information flow from successful proteins back to the DNA that encodes them. Transcriptional induction of the lac operon, even in the presence of another, utilizable carbon source, did not stimulate the occurrence of Lac+ mutants in the absence of lactose, indicating that the role of the selective agent is not merely to induce transcription. The absence of two DNA repair pathways-methyl-directed mismatch repair and alkylation repair-also did not result in an accumulation of Lac+ mutants in the absence of ...

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Get natural cures for Adenylosuccinate lyase deficiency that can make a difference in your life or the life of someone you love with alternative treatments.

Definition of adenylosuccinate lyase. Provided by Stedmans medical dictionary and Drugs.com. Includes medical terms and definitions.

Our lab studies hypoxanthine guanine phosphoribosyltransferase and adenylosuccinate synthetase, enzymes involved in purine salvage in the malarial parasite, Plasmodium falciparum. We have also been studying enzymes involved in hemoglobin degradation and glycolysis. Enzymes of these essential pathways are of interest as targets for antimalarial chemotherapy. Protein engineering/ mutagenesis, spectroscopy and X- Ray crystallographic techniques are used to probe the structure, function and dynamics of these enzymes. Other aspects studied include substrate specificity,catalytic and kinetic mechanisms, and protein stability. Insights from these studies would aid the development of new antimalarials.. ...

Adenylosuccinate lyase (ASL) catalyzes 2 reactions in the de novo synthesis of purine nucleotides. In humans, point mutations of this enzyme are associated with mental retardation, autism, and muscle wasting. The sequence of B. subtilis ASL is 27% identical and 17% similar to the human enzyme. We have cloned, expressed, and purified B. subtilis ASL; the crystal structure of a 73% homologous bacterial enzyme is known (PDB #lc3u). We separately mutated 2 amino acids in the B. subtilis ASL (M10L & N276C) equivalent to the mutations identified in human ASL deficiency (M26L & R303C). The purified M10L and N276C possess specific activities of 0.86 and 0.38 units/mg, respectively, as compared to 1.56 units/mg for wild type (WT) enzyme. Both enzymes are similar to WT in conformation and oligomeric state as indicated by circular dichroism and light scattering. The Km for adenylosuccinate (SAMP) is not appreciably different between M1OL (5.6 uM) and WT (4.9 uM); and the pH dependence of Vmax is also ...

Berry, A and Vamplew, P (2004) PoD Can Mutate: A Simple Dynamic Directed Mutation Approach for Genetic Algorithms. In: AISAT2004: International Conference on Artificial Intelligence in Science and Technology, 21-25 November 2004, Hobart, Tasmania, Australia. ...

Adenylosuccinate Lyase; Catalyzes Two Steps In The de Novo Purine Nucleotide Biosynthetic Pathway; Expression Is Repressed By Adenine And Activated By Bas1p And Pho2p; Mutations In Human Ortholog ADSL Cause Adenylosuccinase Deficiency

Adenylosuccinate Lyase; Catalyzes Two Steps In The de Novo Purine Nucleotide Biosynthetic Pathway; Expression Is Repressed By Adenine And Activated By Bas1p And Pho2p; Mutations In Human Ortholog ADSL Cause Adenylosuccinase Deficiency

Banerjee, Sanchari and Agrawal, Monika J and Mishra, Diptimayee and Sharan, Siddharth and Balaram, Hemalatha and Savithri, Handanhal S and Murthy, Mathur RN (2014) Structural and kinetic studies on adenylosuccinate lyase from Mycobacterium smegmatis and Mycobacterium tuberculosis provide new insights on the catalytic residues of the enzyme. In: FEBS JOURNAL, 281 (6). pp. 1642-1658. Chittori, Sagar and Simanshu, Dhirendra Kumar and Banerjee, Sanchari and Murthy, Ambika Mosale Venkatesh and Mathivanan, Subashini and Savithri, Handanahal Subbarao and Murthy, Mathur Ramabhadrashastry Narasimha (2013) Mechanistic features of Salmonella typhimurium propionate kinase (TdcD): Insights from kinetic and crystallographic studies. In: BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, 1834 (10). pp. 2036-2044. ...

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A good complement to a junk DNA FAQ would be a mechanisms of mutation FAQ, which I dont think exists anywhere. People seem to treat mutation as some kind of magically process and therefore get mislead into all kinds of directed mutation, etc. stuff ...

A good complement to a junk DNA FAQ would be a mechanisms of mutation FAQ, which I dont think exists anywhere. People seem to treat mutation as some kind of magically process and therefore get mislead into all kinds of directed mutation, etc. stuff ...

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Terms of use. Disclaimer. Privacy Statement.. The information contained on this site is for general informational purposes only. It is not a substitute for expert medical advice, and does not take your medical history or specific circumstances into consideration. Always seek your doctors advice if you have a medical or health-related condition. While every effort has been made to ensure that the above information was correct at the time of writing; medical knowledge is constantly being reviewed and updated, and the above information may therefore be superseded by additional knowledge.. ...

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TY - JOUR. T1 - Genetic demonstration of bidirectionality in the high affinity purine base transporter of mutant mouse S49 cells.. AU - Beck, J. T.. AU - Ullman, B.. N1 - Copyright: Medline is the source for the citation and abstract of this record.. PY - 1987/2/15. Y1 - 1987/2/15. N2 - A mutant cell line was selected from wild type S49 lymphoblasts that expressed a novel high affinity purine base transport system not found in parental cells or any other mammalian cell line (Aronow, B., Toll, D., Patrick, J., Hollingsworth, P., McCartan, K., and Ullman, B. (1986) Mol. Cell. Biol. 6, 2957-2962). In order to determine whether this nucleobase transport system was bidirectional, mutant cell lines possessing this high affinity base transport capability were derived from a nucleoside transport-deficient derivative of an adenylosuccinate synthetase-deficient S49 cell line. The resulting progeny excreted significantly greater amounts of purine into the cell culture medium than parental cells. This ...

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Terms of use. Disclaimer. Privacy Statement.. The information contained on this site is for general informational purposes only. It is not a substitute for expert medical advice, and does not take your medical history or specific circumstances into consideration. Always seek your doctors advice if you have a medical or health-related condition. While every effort has been made to ensure that the above information was correct at the time of writing; medical knowledge is constantly being reviewed and updated, and the above information may therefore be superseded by additional knowledge.. ...

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The effect of 3-mercaptopicolinate, an inhibitor of phosphoenolpyruvate carboxykinase [GTP:oxaloacetate carboxy-lyase (transphosphorylating), EC 4.1.1.32], was tested on NH3 formation via the purine nucleotide cycle and glutamate dehydrogenase (EC 1.4.1.2). NH3 excretion in rats increased 70-fold after 48 h of NH4Cl feeding, from 12.2 +/- 4.5 to 862 +/- 190 mumol/mg of creatinine. At 4 h after a single intraperitoneal injection of 3-mercaptopicolinate into NH4Cl-fed rats, NH3 excretion was inhibited by 93%. Kidneys of NH4Cl-fed plus 3-mercaptopicolinate-treated rats, compared with those of NH4Cl-fed rats, showed a 3.5-fold increase in the content of IMP, 5-fold increase in adenylosuccinate, 4-fold increase in aspartate, and a 30% increase in AMP. 3-Mercaptopicolinate completely inhibited NH3 and glucose formation from glutamate in tubules from acidotic rats and NH3 formation from aspartate in kidney perfusion experiments. When transamination in tubules was prevented by ...

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References for Abcams Recombinant mouse RCSD 1 protein (ab116533). Please let us know if you have used this product in your publication

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