Purpose.: Activation or dysregulation of the Sonic hedgehog (Shh) and Wnt signaling pathways is suggested to lead to the development of many human malignancies. In this study, we investigated Shh and Wnt signaling protein expression in eyelid sebaceous gland carcinoma, and analyzed their correlation with clinical characteristics of the tumor. Methods.: Patients who underwent surgical resection of eyelid sebaceous gland carcinoma from 1999 to 2011 were recruited for the study. Immunohistochemical stainings of Shh signaling proteins (Shh, Gli-1, Gli-2, Gli-3, and ABCG2) and Wnt signaling proteins (Wnt, glycogen synthase kinase 3β, β-catenin, lipoprotein receptor-related protein [LRP], and c-Myc) were conducted. Results.: Thirty-seven cases of eyelid sebaceous gland carcinoma were included in this study. Twenty-nine patients showed no metastasis, and eight patients showed lymph node or distant metastasis. Shh, ABCG2, and Wnt proteins were more highly expressed in the group with metastasis than in ...

Purpose.: To investigate the expression of cancer stem cell (CSC) marker proteins in eyelid sebaceous gland carcinoma and evaluate the clinical significance. Methods.: Archival tissue blocks from 50 cases of eyelid sebaceous gland carcinoma were tested via immunohistochemistry for 16 putative CSC markers. Levels of protein expression were analyzed alongside various clinicopathologic parameters such as metastasis-free survival time. Results.: Ten patients (20%) showed nodal or distant metastasis during the follow-up period (median, 35.2 months; range, 1-128 months) without any mortality in our series. Among the 16 markers, ALDH1, CD44, CD133, ABCG2, Sox4, Sox9, and slug were selected for candidates of CSC markers because they were frequently and predominantly found in the tumor cells compared with control tarsus cells, which showed negative or very low expression. Univariate analysis revealed that ALDH1, CD133, and ABCG2 were significantly associated with metastasis; patients with ALDH1- or ...

The finding of a sebaceous carcinoma in a mature teratoma is rare in human pathology, with fewer than 10 cases currently reported in the literature. In this article, we report a case of sebaceous carcinoma in a mature teratoma of the ovary in a 59-year-old patient and discuss its histological findings.. ...

A primary characteristic of sebaceous carcinoma is pagetoid spread, the dissemination of both individual tumor cells and small clusters of tumor cells within the epidermis or conjunctival epithelium (see Fig 13-25B). The pagetoid areas do not have a direct connection to the main portion of the tumor. Another characteristic is the complete replacement of conjunctival epithelium by tumor cells, or sebaceous carcinoma in situ (see Fig 13-25C). This particular characteristic may make complete excision of sebaceous carcinoma challenging.. Treatment of sebaceous carcinoma typically involves wide local excision of the tumor. Widespread conjunctival epithelial involvement or deeply invasive tumors may require exenteration. Because it can be difficult to identify pagetoid spread or sebaceous carcinoma in situ on frozen sections, permanent sections are generally considered more reliable for evaluation of surgical resection margins than frozen sections of margins or Mohs technique. Before definitive ...

Sebaceous carcinoma is an uncommon and aggressive malignant cutaneous tumor.[1] Most are typically about 10 mm in size at presentation.[2] This neoplasm is thought to arise from sebaceous glands in the skin and, therefore, may originate anywhere in the body where these glands are found. Because the periocular region is rich in this type of gland, this region is a common site of origin.[3][4] The cause of these lesions are, in the vast majority of cases, unknown. Occasional cases may be associated with Muir-Torre syndrome.[5][6]. This type of cancer usually has a poor prognosis because of a high rate of metastasis.[2]. ...

Sebaceous carcinoma arises from the glands within the eyelids, caruncle, or eyebrow. They are more common in middle-aged patients.

sebaceous cell carcinoma is found most frequently in the ocular region, which accounts for 75% of cases. The parotid gland is the most common site outside the ocular region, accounting for about 20% of cases.

sebaceous cell carcinoma is found most frequently in the ocular region, which accounts for 75% of cases. The parotid gland is the most common site outside the ocular region, accounting for about 20% of cases.

sebaceous cell carcinoma is found most frequently in the ocular region, which accounts for 75% of cases. The parotid gland is the most common site outside the ocular region, accounting for about 20% of cases.

History: 55 year old woman with enlarging eyelid mass, about 2cm. Biopsy revealed sebaceous carcinoma which must be differentiated from squamous cell carcinoma (and sometimes from basal cell carcinoma) due to different clinical consequences. Sebaceous carcinoma of the periorbital region can be a diagnostic challenge for the clinican and pathologist. Immunohistochemistry may help in this regard ( see reference Sinard JH, Archives of Opthalmology, 117:776-83, 1999). ...

Microcystic adnexal carcinoma (MAC) is a low-grade malignant tumor of the skin. Histologically, this tumor shows a biphasic pattern, with cords and nests of basaloid cells, as well as keratin horn cysts. This biphasic histological appearance has been interpreted by some authors as a sign of double eccrine and folliculosebaceous-apocrine differentiation, whereas some other authors defend a solely eccrine differentiation. In this context, sebaceous differentiation in MAC would support the first option. However, there are only 3 cases of MAC with sebaceous differentiation in the literature, and all of them were reported before adipophilin was available, which in the appropriate context (eg, testing clear cells for sebaceous vs eccrine differentiation) is very useful ...

There are different types of cancer that affect various internal and external parts of the eye, although all these cancers are quite uncommon. Some of these are chloridal melanoma, iris melanocytoma, sebaceous carcinoma of the eyelid and iris melanoma are

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Our work has confirmed previous reports demonstrating the expression of Ki67, p53, and p21WAF1 in topologically distinct compartments in normal sebaceous glands. The expression of p21WAF1 in the absence of p53 positivity in the differentiating compartment of normal sebaceous glands is consistent with previous work indicating that p53 independent upregulation of p21WAF1 is associated with cellular differentiation.1-3,5-7 p21WAF1 positivity of postmitotic cells immediately adjacent to the proliferating compartment is consistent with a role for p21WAF1 in early differentiation, perhaps initiating cell cycle arrest.. In sebaceous adenoma and sebaceoma, both benign proliferations of the sebaceous glands, topological control was maintained, with the distribution of markers being similar to that seen in normal sebaceous glands, although the proliferative compartment was expanded.. The complete loss of compartmentalisation of markers seen in the sections of sebaceous carcinoma suggests loss of ...

to the editor: Sebaceous cell carcinoma of the eyelid is the fourth most common malignancy in the periocular region in the United States (basal cell carcinoma, squamous cell carcinoma, and melanoma are the leading three causes) and the second most common malignancy in China (basal cell carcinoma is the leading cause).1,2 Diagnosis and therapy tend to be delayed because sebaceous carcinoma is often mistaken for benign entities such as chalazion, conjunctivitis, or blepharitis.3. A 74-year-old woman presented to her ophthalmologist with conjunctival erythema and slight tenderness of her upper eyelid. She was diagnosed with conjunctivitis and prescribed erythromycin 0.5% ophthalmic ointment. At her one-month follow-up visit, she continued to have erythema and had also developed a small tender papule. A diagnosis of chalazion was made, and the patient was instructed to continue her antibiotic ointment and to apply warm compresses four times daily to the eye. At her two-month follow-up visit, the ...

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Most patients diagnosed with SC are treated with surgery. Two types of surgery are used to remove SC:. Excision: During this surgery, the surgeon removes the tumor and some surrounding tissue that looks healthy. This helps to remove cancer that may have traveled to an area that still looks healthy. An area can look healthy if it contains just a few cancer cells.. Mohs surgery: Because many SCs develop on an eyelid or other area with little extra skin, Mohs (pronounced moes) surgery may be recommended. This specialized surgery is only used to treat skin cancer. This surgery allows the Mohs surgeon to remove less tissue yet remove the entire tumor.. During Mohs surgery, the Mohs surgeon cuts out the tumor plus a very small amount of healthy looking tissue surrounding the tumor. While the patient waits, the Mohs surgeon uses a microscope to look at what was removed. The surgeon is looking for cancer cells. If the Mohs surgeon finds cancer cells at the edge of the removed tissue, the surgeon will ...

ABHD5, PGRMC1 and FDFT1 are novel markers for sebaceous carcinoma and can reliably distinguish sebaceous neoplasms from non-sebaceous tumors, specifically basal cell carcinoma (BCC) with clear cell features ...

Eye neoplasms can affect all parts of the eye, and can be a benign tumor or a malignant tumor (cancer). Eye cancers can be primary (starts within the eye) or metastatic cancer (spread to the eye from another organ). The two most common cancers that spread to the eye from another organ are breast cancer and lung cancer. Other less common sites of origin include the prostate, kidney, thyroid, skin, colon and blood or bone marrow. Tumors in the eye and orbit can be benign like dermoid cysts, or malignant like rhabdomyosarcoma and retinoblastoma. The most common eyelid tumor is called basal cell carcinoma. This tumor can grow around the eye but rarely spreads to other parts of the body. Other types of common eyelid cancers include squamous carcinoma, sebaceous carcinoma and malignant melanoma. The most common orbital malignancy is orbital lymphoma. This tumor can be diagnosed by biopsy with histopathologic and immunohistochemical analysis. Most patients with orbital lymphoma can be offered ...

Papillomas or warts are easily recognized skin or mucous membrane tumors. They are common in wild species and are particularly well known in deer (Cosgrove and Fay 1981; Sundberg and Nielson 1981). Most of these tumors are caused by papillomaviruses (PVs). Tumors can become quite large and numerous and persist for prolonged periods, but they usually regress, providing the individual with long-term immunity to future infections. Occasionally, the tumors will progress to squamous cell carcinoma, adenosquamous carcinoma, or sebaceous carcinoma that will eventually kill the host if not treated. Specific mucosotropic PV types and those infecting immunodeficient individuals are prone to induce malignancies. Virtually all mammalian species are hosts for one of more PV. This chapter provides an overview of PV infections in mammals ...

Eyelid tumours are fortunately uncommon, and most are not cancers that can spread elsewhere in the body. However, if they are not treated, they will grow and ultimately cause damage to the eyelid and surrounding tissues. Surgery is the treatment of choice for all eyelid tumours and they should be removed promptly to ensure the best outcome. Surgical excision is almost always curative and the lesion can usually be removed without significant cosmetic impact, especially if done at an early stage. Although the diagnosis may be obvious at your consultation, in some cases a preliminary biopsy will be necessary to confirm the precise type of tumour prior to definitive treatment. This biopsy is performed under local anaesthetic and a small piece of the tumour is removed to be examined under a microscope.. ...

Malignant tumours affecting the eyelid include basal cell carcinoma (85% to 95%), squamous cell carcinoma (approximately 5%), sebaceous carcinoma (1% to 5%), and malignant melanoma (1%). Non-Hodgkins lymphoma of the eyelid is rare. This report is of an 80-year-old woman who presented with diffuse left upper eyelid swelling, clinically suspected to be a haemangioma. Rare diseases should be considered in differential diagnoses because they have the potential for rapid systemic involvement and may need treatment that is different from that of other common diseases at the same site.. ...

Breast cancer is common in women and its metastases involve the skin in approximately one quarter of patients. Accordingly, metastatic breast cancer shown to be cutaneous through histology must be distinguished from a wide variety of other neoplasms as well as the diverse morphologic variants of breast cancer itself. We report the case of a 61-year-old Caucasian woman with cutaneous metastases of a bilateral ductal breast carcinoma that in histopathological examination mimicked an adnexal neoplasm with sebaceous differentiation. Against the background of metastatic breast carcinoma, dermatopathological considerations of sebaceous differentiation of skin lesions are presented and discussed focusing on the rare differential diagnosis of sebaceous carcinoma of the breast.

Between April 2014 and June 2019, 16 patients with orbital tumors underwent either ETOA or EEA at the authors institution. Based on the neuro-topographic four-zone model of the orbit with its tumor epicenter around the optic nerve in the coronal plane, ETOA (n = 10, 62.5%) was performed for tumors located predominantly superolateral to the nerve and EEA (n = 6, 37.5%) for those located predominantly inferomedial to the nerve. Eight patients (50%) presented with intraconal tumors and 8 (50%) with extraconal ones. The orbital tumors included orbital schwannoma (n = 6), cavernous hemangioma (n = 2), olfactory groove meningioma (n = 1), sphenoorbital meningioma (n = 1), chondrosarcoma (n = 1), trigeminal schwannoma (n = 1), metastatic osteosarcoma (n = 1), mature cystic teratoma (n = 1), sebaceous carcinoma (n = 1), and ethmoid sinus osteoma (n = 1). The clinical outcomes and details of surgical techniques were reviewed. ...

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Periocular sebaceous gland carcinoma: do androgen receptor (NR3C4) and nuclear survivin (BIRC5) have a prognostic significance? ...

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TY - JOUR. T1 - Clinical, dermoscopic and reflectance confocal microscopy features of sebaceous neoplasms in Muir-Torre syndrome. AU - Moscarella, E.. AU - Argenziano, G.. AU - Longo, C.. AU - Cota, C.. AU - Ardigò, M.. AU - Stigliano, V.. AU - Mete, L. S.. AU - Donati, P.. AU - Piana, S.. AU - Silipo, V.. AU - Catricalà, C.. AU - Albertini, G.. AU - Zalaudek, I.. PY - 2013/6. Y1 - 2013/6. N2 - Background Muir-Torre syndrome (MTS) is an autosomal-dominant disorder characterized by the association of sebaceous tumors or keratoacanthomas with an early onset visceral cancer in the spectrum of Lynch syndrome. Observations A total of 20 sebaceous tumors including 18 sebaceous adenoma and two sebaceomas of six patients with MTS were analysed. Two main clinico-dermoscopic features were observed: (1) clinically pink to white papules/nodules with a central crater, dermoscopically characterized by radially arranged, elongated crown vessels surrounding opaque structureless yellow areas at times covered ...

DNA was extracted from 86 lesions including 17 proliferating tricholemmal and trichilemmal tumors, 15 trichoblastomas, 7 trichoadenomas, 4 pilomatricomas, 1 pilomatrical carcinoma, 4 basal cell carcinomas (BCCs) with shadow cells, 2 trichofolliculomas, 3 BCCs with sebaceous differentiation, 9 sebaceous adenomas, 6 sebaceomas, 14 sebaceous carcinomas (both ocular and extraocular forms), 2 gigantic horns, and 2 apocrine mixed tumors with shadow cells and subjected to polymerase chain reaction with newly designed primers encompassing glycogen synthase kinase-3beta phosphorylation sites of the CTNNB1 gene ...

Results There were a total of 160 male patients (48%) and 173 female patients (52%). The median age at diagnosis was 66 years (range 31-95) for male subjects and 67 years (35-99) for female subjects. The average annual age-standardised incidence rate of all eyelid cancers over the 13 years was 5.0 per million. A significant decrease in rates from 6.6 per million in the 1996-1998 period to 3.9 per million in the 2005-2008 period with an annual percentage change of 3.6% (95% CI −6.5 to 0.7%; p=0.02) was noted for women. The most common cancer was basal cell carcinoma (82%), followed by sebaceous gland carcinoma (11%) and squamous cell carcinoma (4%).. ...

TY - JOUR. T1 - Muir-Torre syndrome. T2 - A case of this uncommon entity. AU - Weinstein, Andrew. AU - Nouri, Keyvan. AU - Bassiri-Tehrani, Shirley. AU - Flores, Francisco. AU - Jimenez, Gloria. PY - 2006/3/1. Y1 - 2006/3/1. N2 - A 69-year-old Hispanic woman presented for the evaluation of nodules on the head and back. In the past, she had been treated for basal cell carcinoma (BCC) of the face; the referring physician was concerned that the new lesions might also be BCC. The patient had an extensive past medical history. In addition to BCC, she had been treated for breast cancer, colon cancer, and cervical cancer prior to emigrating to the USA. Her colonic malignancy had been localized proximal to the splenic flexure. She also had a history of colonic polyps and distal colonic villous adenoma. She denied ever being treated with radiation. Further details of her medical history and cancer staging were not available. Her family history was significant for a sister with colon cancer and ...

Benign and cancerous tumors of the eyelid are common. In sunny climates, the lower eyelids are a common location for skin cancers. New lesions of the eyelids and eyelid margins should be carefully assessed and frequently need to be biopsied. In general, early detection yields excellent results with removal and reconstruction. In advanced cases, more complex reconstruction may require grafting or rotation flaps to fully repair the area removed with the tumor.. ...

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Swollen eyelid toddler - My child is 11 months old and his left eyelid is very swollen and little red today. It started looking puffy yesterday and now it is much worse..? See yourMD first. I would recommend seeing your pediatrician first.

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TY - JOUR. T1 - The Cancer Family Syndrome Rare Cutaneous Phenotypic Linkage of Torres Syndrome. AU - Lynch, Henry T.. AU - Lynch, Patrick M.. AU - Pester, Judith. AU - Fusaro, Ramon M.. PY - 1981/4. Y1 - 1981/4. N2 - Sebaceous neoplasia have been observed in members of four families exhibiting the cancer family syndrome (CFS). This disorder is characterized by adenocarcinomas, particularly involving the (proximal) colon, endometrium, and ovary; an excess of multiple primary cancer; early age of cancer onset; and autosomal dominant pattern of inheritance. Multiple adenomatous polyps are lacking in this disorder. In four patients from three of these cancer-prone kindreds, cutaneous lesions were accompanied by multiple visceral adenocarcinomas, fulfilling the criteria for Torres syndrome, a disease that heretofore has not shown notable familial clustering characteristic of the CFS. Therefore, the coexistence of rare sebaceous neoplasia and visceral cancer in CFS supports the notion that some ...

This article reports the results of a clinicopathologic study of 44 keratoacanthomas of the eyelid. This tumor characteristically has a rapid development and pr

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Centers RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.. ...

Hi Andrew, I have a 10 year old Yorkie/Maltese (her tummy skin is light coloured, but she has black hair). I noticed a growth on top of her head (about a fingers width away from her right eye) that started growing about a year ago and it has increased in size gradually (no fast growth within a month or anything like that). For your reference, it is now the size of two green peas. I recently gave her a haircut and started worrying more… At first I thought it was a skin tag, but the growth is black in colour. After reading your post, it looks very similar like the sebaceous adenoma (same size and bumpy look, except it is black in colour). It also seems to be attached to the head on one side only (you can move and lift the other side up). Recently, I started putting vitamin E oil on it (for 3 days only) because initially I thought it was a wart (I know it isnt a wart now), but the vitamin e oil seems to have irritated it because when she rubs her head on the floor or when I wipe it with tissue, ...

The sebaceous glands are minute glands of the skin. It is distributed in the entire skin of the human body except for the palms of the hands and soles of the feet. Location, Pictures, Function...

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A swollen eyelid can be caused by inflammation in the tissues around the eye. Learn more about puffy eyelids including symptoms, causes, and treatment.

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We have a 17 week old fox red lab, and just this weekend picked up an 11 week old black lab. All is good, until this morning I looked at the black lab