TY - JOUR. T1 - Loss of heterozygosity patterns of sclerosing hemangioma of the lung and bronchioloalveolar carcinoma indicate a molecular pathogenesis. AU - Dacic, Sanja. AU - Sasatomi, Eizaburo. AU - Swalsky, Patricia A.. AU - Kim, Dong Won. AU - Finkelstein, Sydney D.. AU - Yousem, Samuel A.. N1 - Copyright: Copyright 2008 Elsevier B.V., All rights reserved.. PY - 2004/8. Y1 - 2004/8. N2 - Context.-The histogenesis and origin of sclerosing hemangioma (SH) of lung were uncertain for many years. Many immunohistochemical, ultrastructural, and recent molecular studies support the hypothesis that SH is a neoplasm originating from the cells of the terminal lobular unit, similar to the nonmucinous variant of bronchioloalveolar carcinoma (BAC). Most cases of SH are benign, but they can metastasize to the regional lymph nodes. Objective.-To compare the patterns of allelic loss of tumor suppressor genes in SH and BAC by microdissection-based genotypic analysis. Design.-Microdissection-based loss of ...

Acinar cell carcinoma of lung|Adenocarcinoma of lung|Adenocarcinoma of lung (disorder)|Adenocarcinoma of lung, stage I|Adenocarcinoma of lung, stage I (finding)|Adenocarcinoma of lung, stage II|Adenocarcinoma of lung, stage II (finding)|Adenocarcinoma of lung, stage III|Adenocarcinoma of lung, stage III (finding)|Adenocarcinoma of lung, stage IV|Adenocarcinoma of lung, stage IV (finding)|Adenoid cystic carcinoma of lung|Adenosquamous carcinoma of lung|Alveolar cell carcinoma|BC - Bronchogenic carcinoma|Basaloid squamous cell carcinoma of lung|Bronchial carcinoma|Bronchiolar adenocarcinoma|Bronchiolar carcinoma|Bronchioloalveolar carcinoma|Bronchioloalveolar carcinoma (disorder)|Bronchioloalveolar carcinoma - disorder|Bronchoalveolar cancer|Bronchogenic carcinoma|CA - Cancer of bronchus|CA - Carcinoma of bronchus|CA - Lung cancer|Cancer of bronchus|Carcinoma of bronchus|Carcinoma of lung|Carcinoma of lung parenchyma|Carcinoma of lung parenchyma (disorder)|Carcinosarcoma of lung|Clear cell squamous cell

Vandetanib (ZactimaTM) is a novel, orally available inhibitor of both vascular endothelial growth factor receptor-2 (VEGFR-2) and epidermal growth factor receptor (EGFR) tyrosine kinase. In the present study, a line of transgenic mice with a mouse Egfr gene mutation (delE748-A752) corresponding to a human EGFR mutation (delE746-A750) was established. The transgenic mice developed atypical adenomatous hyperplasia to adenocarcinoma of the lung at around 5 weeks of age and died of lung tumors at approximately 17 weeks of age. In the mice treated with vandetanib (6mg/kg/day), these lung tumors disappeared and the phosphorylations of EGFR and VEGFR-2 were reduced in lung tissues to levels comparable to those of non-transgenic control mice. The median overall survival time of the transgenic mice was 28 weeks in the vandetanib-treated group and 17 weeks in the vehicle-treated group. Vandetanib significantly prolonged the survival of the transgenic mice (log-rank test, p＜0.01); resistance to ...

UroToday - GU OncToday brings coverage of the clinically relevant content needed to stay at the forefront of the dynamic field of GU oncology and urology.

With the increase in the number of lung transplants, it is expected that there will be a corresponding increase in the number of lung cancers reported in these patients. Longevity of the transplant recipients, lung transplantation for chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis, a history of smoking, and the increasing age of the lung donors make lung cancer more likely. Nodules and masses seen in chest imaging in lung transplant patients call for work up until a final diagnosis is achieved because there is a high likelihood of a serious infection or malignancy. The presence of a native lung is a major risk factor for lung cancer occurring in the transplant setting. Lung cancer of donor origin is rare. Bronchioloalveolar carcinoma confined to one lung can potentially be treated by transplanting the affected lung. Treatment for patients with lung cancer in the lung transplant setting has to be individualized because of the complexity of their medical problems and ...

The homogeneous, pink, mucinous alveolar exudate of bronchioloalveolar carcinoma is also PASD-positive. It is not foamy as in pneumocystis pneumonia or granular as in alveolar proteinosis. It stains with alcian blue, whereas the others do not. In this photo, not all of the alveoli are lined by tumor. The tumor cells (arrows) should not be mistaken for hyperplastic type II cells. Protein-rich pulmonary edema fluid can have a similar appearance but is PASD-negative.. Pulmonary alveolar proteinosis--PAS stain ...

Vandetanib (ZactimaTM) is a novel, orally available inhibitor of both vascular endothelial growth factor receptor-2 (VEGFR-2) and epidermal growth factor receptor (EGFR) tyrosine kinase. In the present study, a line of transgenic mice with a mouse Egfr gene mutation (delE748-A752) corresponding to a human EGFR mutation (delE746-A750) was established. The transgenic mice developed atypical adenomatous hyperplasia to adenocarcinoma of the lung at around 5 weeks of age and died of lung tumors at approximately 17 weeks of age. In the mice treated with vandetanib (6mg/kg/day), these lung tumors disappeared and the phosphorylations of EGFR and VEGFR-2 were reduced in lung tissues to levels comparable to those of non-transgenic control mice. The median overall survival time of the transgenic mice was 28 weeks in the vandetanib-treated group and 17 weeks in the vehicle-treated group. Vandetanib significantly prolonged the survival of the transgenic mice (log-rank test, p＜0.01); resistance to ...

HGF was detected in BALF supernatants from nearly all of the patients with BAC and was related to local production, because fresh alveolar cells, recovered by BAL and cultured for 24 h, expressed HGF mRNA and released significant amounts of HGF protein. By contrast, HGF was never detected in BALF supernatants from healthy controls, whose alveolar cells did not express HGF mRNA or release HGF protein. Initial studies showed that HGF is a stromal-derived factor affecting the proliferation and motility of normal and tumoral epithelial cells, especially in NSCLC (24) . It was also shown that tumor cells were a potential source of HGF in NSCLC (25, 26, 27, 28) . We show, for the first time, that tumor-infiltrating neutrophils are a potential source of HGF in patients with BAC-subtype ADC. Indeed, HGF levels in BALF supernatants correlated with neutrophil numbers in alveolar spaces but not with counts of other inflammatory cells (lymphocytes and macrophages). Second, immunostaining of BALF cytospin ...

Numbers of C. elegans in the bacterial zone and non-bacterial zone with different bacteria.a, b, c, d, and e represent B. amyloliquefaciens JX1, Variovorax sp.

VGA is a rare subtype of cervical adenocarcinoma first described by Young and Scully,2 which has been reported to have a more favorable prognosis compared to conventional adenocarcinomas.1 It is characterized by numerous papillary villous structures which are lined by epithelial cells with only mild cytologic atypia. The epithelial cells may be mucinous or non-mucinous, and the central fibrovascular cores of the papillae usually have variable number of inflammatory cells. Associations between VGA and HPV and oral contraceptives have been reported.3,5,7,13,14. The diagnosis of VGA has been demonstrated to be rather challenging on cytology as the cytologic features may be deceptively bland-looking, resulting in its misdiagnosis as reactive glandular cells. Indeed, the initial cytologic impression in one of our three cases was a reactive lesion and the neoplastic cell clusters could have been overlooked if it had not been for the simultaneous punch biopsy specimen that harbored a VGA. There are ...

Lung adenocarcinomas are malignant glandular neoplasms can be well to poorly differentiated. In well differentiated tumors, glands are lined by columnar or mucinous epithelium with basally oriented nuclei containing prominent nucleoli. There frequent mitotic figures. In poorly differentiated adenocarcinomas, the only clue to their glandular nature may be the presence of intracytoplastic mucin, as they form solid sheets. Variants of adenocarcinoma, according to the WHO schema, include bronchioloalveolar, mucinous and papillary (Fletcher). ...

DISEASE CHARACTERISTICS: Histologically confirmed non-small cell lung cancer (NSCLC), including: Squamous cell carcinoma Undifferentiated carcinoma Adenocarcinoma Mixed (i.e., adenocarcinoma with squamous cell carcinoma) No mixed tumors containing small cell lung carcinoma elements Bronchoalveolar carcinoma Large cell carcinoma Bronchoalveolar lavage allowed for diagnosis Advanced or metastatic NSCLC Stage IIIB disease ineligible for combined chemotherapy and radiotherapy OR Stage IV disease Progressive NSCLC during or after first-line therapies with platinum-containing chemotherapy regimens in the advanced or metastatic setting Measurable disease by radiological imaging techniques Previously treated CNS metastases allowed provided: Neurologically stable Oral or IV steroids or anticonvulsants not required No active disease by CT scan or MRI No known leptomeningeal metastases or carcinomatous meningitis. PATIENT CHARACTERISTICS: Age: 18 and over Performance status: ECOG 0-1 Life expectancy: At ...

Introduction: Adenocarcinoma is the most common histologic type of lung cancer. To address advances in oncology, molecular biology, pathology, radiology, and surgery of lung adenocarcinoma, an international multidisciplinary classification was sponsored by the International Association for the Study of Lung Cancer, American Thoracic Society, and European Respiratory Society. This new adenocarcinoma classification is needed to provide uniform terminology and diagnostic criteria, especially for bronchioloalveolar carcinoma (BAC), the overall approach to small nonresection cancer specimens, and for multidisciplinary strategic management of tissue for molecular and immunohistochemical studies. Methods: An international core panel of experts representing all three societies was formed with oncologists/pulmonologists, pathologists, radiologists, molecular biologists, and thoracic surgeons. A systematic review was performed under the guidance of the American Thoracic Society Documents Development and ...

0100] Benzo[a]pyrene-7,8-dihydrodiol promotes checkpoint activation and G2/M arrest in human bronchoalveolar carcinoma H358 cells. Mol Pharmacol, 71: 744-750, 2007. [0101] 9. Ma, Q. Induction of CYP1A1. The AhR/DRE paradigm: transcription, receptor regulation, and expanding biological roles. Curr Drug Metab, 2: 149-164, 2001. [0102] 10. Nebert, D. W., Dalton, T. P., Okey, A. B., and Gonzalez, F. J. Role of aryl hydrocarbon receptor-mediated induction of the CYP1 enzymes in environmental toxicity and cancer. J Biol Chem, 279: 23847-23850, 2004. [0103] 11. Wang, X., Tomso, D. J., Chorley, B. N., Cho, H. Y., Cheung, V. G., Kleeberger, S. R., and Bell, D. A. Identification of polymorphic antioxidant response elements in the human genome. Hum Mol Genet, 16: 1188-1200, 2007. [0104] 12. Aoki, Y., Hashimoto, A. H., Amanuma, K., Matsumoto, M., Hiyoshi, K., Takano, H., Masumura, K., Itoh, K., Nohmi, T., and Yamamoto, M. Enhanced spontaneous and benzo(a)pyrene-induced mutations in the lung of ...

Persistent GGO are usually classified as adenocarcinomas, ranging from premalignant lesions (atypical adenomatous hyperplasia) to invasive disease. They are generally slow-growing lesions. Because their significance can be difficult to determine, optimal follow-up and management are not clearly known. The prognosis of these lesions is driven by their histologic characteristics, which are available only after surgical resection.. The Mayo Clinic team tackling the uncertainties of GGOs includes biomedical imaging engineers, pathologists, pulmonologists and radiologists. They are developing CANARY as a noninvasive quantitative imaging tool designed to differentially categorize CT-detected peripheral subsolid lung nodules and predict underlying pathology and prognosis. Preliminary data suggest that CANARY, utilizing volumetric histogram density analysis (so-called radiologic biopsies), effectively risk-stratifies these nodules.. To further validate this technology, CANARY researchers are using data ...

Cellular atypia in rodent lungs is characterized by one or more of the following features: cytoplasmic basophilia, hyperchromatic nuclei, loss of nuclear polarity, high nuclear to cytoplasmic ratio, karyomegaly, anisokaryosis, and pleomorphism. The atypical cells are often poorly differentiated and may be binucleated. They may have multiple and/or enlarged nucleoli. In the pathology literature, cellular atypia, atypical hyperplasia, and atypical adenomatous hyperplasia have been used synonymously with dysplasia to signify cells and nuclei with abnormal size, shape, organization, and/or tinctoral properties. While individual cells in the alveoli may have features of atypia, cellular atypia can also be seen in areas of bronchial, bronchiolar, or alveolar epithelial hyperplasia or squamous metaplasia. Some of the features listed above may also be seen in regenerating cells (e.g., cytomegaly, karyomegaly, cytoplasmic basophilia, increased nuclear to cytoplasmic ratio). The biological significance of ...

Nectin-like molecule-5 (Necl-5) is an immunoglobulin (Ig)-like molecule that is up-regulated in many types of cancer cells. It was shown experimentally that Necl-5 enhances cell migration, proliferation, and metastasis, but its clinical significance has not been documented. The aim of this study was to observe the expression of Necl-5 in surgically resected primary lung adenocarcinomas and to investigate its clinical significance. A total of 63 surgically resected primary pulmonary adenocarcinoma tissues were investigated by immunohistochemistry for the expression of Necl-5. The relationship between expression of Necl-5 and clinicopathological features was analyzed, and the influence of Necl-5 expression on outcomes in these patients was assessed. A strong expression of Necl-5 by cancer cells was observed in 43 of the 63 tumors. The overexpression of Necl-5 by cancer cells was significantly associated with lymph node metastasis (P = 0.0398), TNM staging (P = 0.0367), and the bronchioloalveolar ...

Kirkby R., Scase T., Wakeling J.E., et al. Journal of Veterinary Internal Medicine, 2006. 20(6): p.1522. In human patients, a well-defined syndrome of sub

I had a CT Scan done last week with found scattered nodules 3 mm to 6 mm in size with ground-glass opacities + moderate emphysema. Does this mean I have lung cancer? I am 56 years old and have only s...

Actions on H.R.559 - 105th Congress (1997-1998): To amend title 38, United States Code, to add bronchiolo-alveolar carcinoma to the list of diseases presumed to be service-connected for certain radiation-exposed veterans.

With the genetic sample method, the GGO will in a clever way select parameter permutations and the GGO modified strategy will export complete trading history for each permutation so that the GWFO can afterwards perform a walk-forward analysis on those trading history files. (Select menu option Recalculate, Genetic Sample Walk-forward) Thus with this approach, all walk-forward calculations takes place within the GWFO stand-alone software. Since the GWFO stand-alone executes much faster than the EL interpreter, the Genetic sample walk-forward method is much faster than the Concurrent method ...

The Smoking Guns mug shot collection is divided into celebrities and civilians.. More than 325 high-profile perps can be found in the 11 categories at left, with one celebrity also being featured in the box at right. Or just click All Celebs to see the stars on one page. Below youll find our constantly updated feed of civilian booking photos, each of which also lands in one of 24 categories at left. These include sections devoted to the battered (Ouch), pole workers (Strippers), and fans of lower back artwork (Tramp Stamps). And, of course, Scarface devotees (Pacino).. ...

Epstein-Barr virus (EBV) is a ubiquitous herpesvirus, and most people have serological evidence of previous viral infection at adult age. EBV is associated with infectious mononucleosis and human cancers, including some lymphomas and gastric carcinomas. Although EBV was first reported in lymphoepithelioma-like gastric carcinoma, the virus was also found in conventional adenocarcinomas. In the present study, 53 gastric carcinomas diagnosed in Sao Paulo State, Brazil, were evaluated for EBV infection by non-isotopic in situ hybridization with a biotinylated probe (Biotin-AGACACCGTCCTCACCACCCGGGACTTGTA) directed to the viral transcript EBER-I, which is actively expressed in EBV latently infected cells. EBV infection was found in 6 of 53 (11.32%) gastric carcinomas, mostly from male patients (66.7%), with a mean age of 59 years old. Most EBV-positive tumors were in gastric antrum. Two EBV-positive tumors (33.3%) were conventional adenocarcinomas, whereas four (66.7%) were classified as ...

Crazy paving was thought to be specific for alveolar proteinosis, but is also seen in many other diseases such as pneumocystis carinii pneumonia, bronchoalveolar carcinoma, sarcoidosis, nonspecific interstitial pneumonia (NSIP), organizing pneumonia (COP), adult respiratory distress syndrome and pulmonary hemorrhage.. Alveolar proteinosis is a rare diffuse lung disease of unknown etiology characterized by alveolar and interstitial accumulation of a periodic acid-Schiff (PAS) stain-positive phospholipoprotein derived from surfactant.. ...

Define bronchioalveolar carcinoma. bronchioalveolar carcinoma synonyms, bronchioalveolar carcinoma pronunciation, bronchioalveolar carcinoma translation, English dictionary definition of bronchioalveolar carcinoma. n. pl. car·ci·no·mas or car·ci·no·ma·ta An invasive malignant tumor derived from epithelial tissue that tends to metastasize to other areas of the body....

The Extent and Zonal Location of Prostatic Intraepithelial Neoplasia and Atypical Adenomatous Hyperplasia : Relationship with Carcinoma in Radical Prostatectomy Specimens ...

2 MANECs are rare entities known to be associated with biological aggressiveness and poor patient survival, but otherwise remain incompletely characterized.3 In a recent study that compared CRC-NE to conventional colorectal carcinoma, CRC-NE was more frequently located in the right colon (76% vs. 46%), more often presented with metastasis (59% vs. 18%) and often had perineural (68%), lymphatic (97%), and venous (62%) invasion and high tumor budding (71%). BRAF V600E mutation was more common in CRC-NE compared with conventional CRC (53% vs. 12%). Neuroendocrine differentiation, high stage, BRAF mutation without microsatellite instability, and signet ring histology were all associated with poor overall survival.4 In the same study, CRC-NE was further divided into large cell neuroendocrine carcinoma (LCNEC), MANEC composed of LCNEC and conventional adenocarcinoma (MANEC-conventional type), and MANEC composed of LCNEC and signet ring cell carcinoma (MANEC-signet ring type). MANEC-signet ring type ...

The abdomen of Wistar rats was irradiated locally with 1000 to 2000 rads. Approximately 2 months following irradiation, visible nodules were found in the intestines of the groups receiving irradiation. Nodule incidence was 80 to 100% in groups that received 1750 or 2000 rads, 50% in the 1500-rad groups, and 3% in the 1000-rad groups, respectively.. The histology of the nodules revealed adenomatous hyperplasia, including invasion of submucosa, muscle layers, and serosa of the small intestine accompanied by an area of fibrous tissue resulting from desmoplastic reaction by irradiation injury.. ...

Kass P.H., Peterson M.E., Levy J., et al. , 1999. 13(4): p.323-9. The pathologic changes associated with hyperthyroidism (adenomatous hyperplasia, adenoma of

Versuri Infinity de Mariah Carey: Ooh aah ooh aah... / Why you mad? / Talkin bout youre mad / Could it be that you just lost the best youve ...

2.0 2.1 2.2 2.3 2.4 Kobashi, Y.; Sugiu, T.; Mouri, K.; Irei, T.; Nakata, M.; Oka, M. (Jun 2008). Multifocal micronodular pneumocyte hyperplasia associated with tuberous sclerosis: differentiation from multiple atypical adenomatous hyperplasia.. Jpn J Clin Oncol 38 (6): 451-4. doi:10.1093/jjco/hyn042. PMID 18535095. ...

Thirty-seven nonhemolytic/nonbacteriocinogenic mutations in Enterococcus (Streptococcus) faecalis plasmid pAD1 were generated by Tn917 insertion. All were found to belong to one of two complementation classes. Each class of mutants secreted either hemolysin/bacteriocin (Hly/Bac) component A or L into the culture medium. DNA encoding Hly/Bac was cloned in Escherichia coli in which both components of the hemolysin were expressed individually and collectively. The region encoding components A and L was further defined by deletion analysis and physically mapped. A total of approximately 8.4 kilobases of pAD1 DNA were observed to be required for hemolysin expression. Hly/Bac activity of the wild-type and the inactive L substance was observed to be heat stable. Active Hly/Bac resulting from incubating separately secreted components A and L was also found to be heat stable. The results indicate that component A activates component L and that activated component L possesses the Hly/Bac activity. ...

Introduction: Lung adenocarcinoma has a complex variety of different hystopathologic subtypes with distinct epidemiology, pathology and prognosis. Pulmonary adenocarcinoma with enteric differentiation is a rare variant defined as a tumor with more than 50% of colorrectal-like components, immunohistochemistry (IHC) positive for at least one marker of enteric differentiation (CK20, CDX-2 or MUC2) and no evidence of other malignancies. Case Series: Patients were identified in a review of a set of adenocarcinomas, apparently originated in colon, but posteriorly accessed as lung adenocarcinomas. Median age was 57.6 years, were all Caucasian subjects and presented with metastatic disease. The median size were 6.3 cm at the time of diagnosis and all had spiculated shape forms at CT scans. Microscopic description revealed a lepidic (mucinous) adenocarcinoma in all five cases. Immunohistochemistry were positive for CK20 or CDX-2 in all these cases and was negative for CK7 in one patient. Conclusion: The use of

This intriguing case showed various histologic patterns, including a solid pattern (the main component), a bronchioloalveolar papillary pattern, lymphatic invasion, a sarcomatous pattern, and a hypocellular osteoblastic pattern.. Only a few cases of lung carcinoma with cyst formation have been reported [1-6]. The possible mechanisms for the development of malignant cysts include necrosis of the central core of the tumor followed by discharge of the necrotic content [6]. In this case report, the large cyst contained only necrotic material and no viable cells were included, although the viability of the tumor nodule itself was very high.. Etiothanatopathological (here, etiothanatopathology has been coined from etio logy, thanato logy, and patho logy) analysis of autopsy cases is important. The autopsy findings may give an insight into and lead to a better understanding of the heterogeneity and clonal expansion of lung adenocarcinoma. ...

Tumors with a massive inflammatory infiltration are described in several organs. There is agreement about considering the inflammatory infiltration as the hosts immune response to neoplastic cells; such neoplasms indeed have a better prognostic outc

In this case-based interview, Mark Socinski, MD, describes the case of a patient with metastatic non-driver lung adenocarcinoma with brain and bone metastases.

Указанные физико-химические характеристики являются типичными для данного продукта. В результате постоянных улучшений указанные характеристики могут быть изменены производителем без предварительного уведомления, однако полное соответствие продукта спецификациям гарантируется. Компания AIMOL-M b.v. прилагает все усилия для обеспечения точности указанной информации, но не несет никакой ответственности за любые убытки или ущерб, вызванными неполнотой данного текста, и, как результат, использованием данного продукта для любых применений, кроме ...

We report on 2 infants with PHHI for whom focal lesions of the pancreas were diagnosed during laparoscopy and laparoscopically enucleated. Both children were cured at the age of 1 month. One year after surgery, both patients are well and normoglycemic. Functional data from patient tissue analyses and genotyping in both cases revealed that PHHI was a consequence of defects in β-cell KATP channels. For both children, mutations in the SUR1 gene were found; the mutations were of paternal origin in both cases, as reported for focal hyperinsulinism. The focal origins of PHHI were confirmed with histologic diagnoses.. Focal adenomatous hyperplasia as a cause of PHHI was observed first by Kloppel et al7 in 1975 and was noted by Goossens et al8 in 1989 in a large study of 24 pancreata from surgically treated patients with PHHI. Since those observations, focal lesions as a cause of intractable hyperinsulinism have been consistently reported. The presumed incidence may be as high as 30% to 60% of cases of ...

TY - JOUR. T1 - Extensive adenocarcinoma and large cell undifferentiated carcinoma of the lung treated with 5-FU, vincristine, and mitomycin C (FOMi). AU - Miller, T. P.. AU - McMahon, L. J.. AU - Livingston, R. B.. PY - 1980. Y1 - 1980. N2 - Fifty-six patients with extensive (52 with TNM stage III M1 disease and four with TNM stage III M0 disease) adenocarcinoma (46 patients) and large cell undifferentiated carcinoma (ten patients) of the lung were treated with combination chemotherapy consisting of 5-FU, vincristine, and mitomycin C (FOMi). The ten patients had not received prior chemotherapy. The overall response rate was 41% (23 of 56 patients). Four patients achieved a complete response and 19 achieved a partial response. In 12 patients the disease was stable. Response did not vary by cell type: adenocarcinoma, 18 of 43 patients (42%); large cell carcinoma, four of ten (40%); and alveolar cell carcinoma, one of three (33%). The response varied by initial performance status. For a Karnofsky ...

TY - JOUR. T1 - Tumor volume and lymphovascular space invasion as a prognostic factor in early invasive adenocarcinoma of the cervix. AU - Murakami, Isao. AU - Fujii, Takuma. AU - Kameyama, Kaori. AU - Iwata, Takashi. AU - Saito, Miyuki. AU - Kubushiro, Kaneyuki. AU - Aoki, Daisuke. PY - 2012/6. Y1 - 2012/6. N2 - Objective: The aim of this study was to investigate the risk and recurrence of early invasive adenocarcinoma of the cervix, and to determine whether non-radical methods of management could be performed. Methods: The medical and histopathological records of 50 patients with early invasive adenocarcinoma of the cervix treated at Keio University Hospital between 1993 and 2005 were reviewed, and compared with the literature. Results: The median follow-up period was 64.3 months. The depth of stromal invasion was ≤3 mm in 33 cases and ,3 mm, but ≤5 mm in 17 cases. The horizontal spread was ≤7 mm in 25 cases and ,7 mm in 25 cases. One of the 33 cases that had tumor volumes of ≤500 mm ...

Top 10 cancers for 1371_s_at (Homo sapiens, Affymetrix Probeset): liver, hemangioma, NOS, liver, unspecified, liver, dysplastic nodule, bronchus or lung, bronchiolo-alveolar adenocarcinoma, breast, intraductal micropapillary carcinoma, breast, mucinous adenocarcinoma, bronchus or lung, papillary adenocarcinoma, NOS, bronchus or lung, acinar cell carcinoma, bronchus or lung, adenocarcinoma, NOS, bronchus or lung, adenocarcinoma with mixed subtypes

Polycyclic aromatic hydrocarbons and their quinines modulate the metabolic profile and induce DNA damage in human alveolar and bronchiolar cells, Deepak Gurbani, Santosh Kumar Bharti, Ashutosh Kumar, Alok k. Pandey, Godson R E E Ana, Ambrish Verma, Altaf Husain Khan, Devendra K. Patel, M K R Mudiam, Swatantra K. Jain, Raja Roy, Alok Dhawan, International Journal of Hygiene and Enviornmental Health(2013), http://dx.doi.org/10.1016/J.ijheh.2013.04. ...

Expression of ANLN (ANILLIN, scra, Scraps) in spleen tissue. Antibody staining with HPA005680, HPA050556, CAB033902, CAB062547 and CAB068175 in immunohistochemistry.

Expression of ANLN (ANILLIN, scra, Scraps) in oral mucosa tissue. Antibody staining with HPA005680, HPA050556, CAB033902 and CAB062547 in immunohistochemistry.

TY - JOUR. T1 - Warthins tumour of the parotid glands, adenomatous hyperplasia and oncocytic adenomatous hyperplasia of the intranodal heterotopic salivary glands. T2 - A comparative immunohistochemical assessment. AU - Shinohara, Masanori. AU - Nakamura, Seiji. AU - Harada, Takeshi. AU - Yamada, Kazuto. AU - Shrestha, Prashanta. AU - Mori, Masahiko. N1 - Copyright: Copyright 2017 Elsevier B.V., All rights reserved.. PY - 1996. Y1 - 1996. N2 - Objectives: In adenomotous hyperplasia (AH) and oncocytic adenomatous hyperplasia (OAH) of the intranodal heterotopic salivary gland tissue and Warthins tumours of the parotid glands, the expression of various intermediate filament proteins and other tissue markers in the epithelial components were compared, since they share common histopathological characteristics with both eosinophilic luminal cells and basal cells. Materials and Methods: Tissue specimens from 79 intraparotid and extraparotid cervical lymph nodes containing heterotopic salivary gland ...

Fluorodeoxyglucose (FDG)-positron emission tomography (PET) has proved to be an accurate non-invasive imaging test for differentiating benign from malignant solitary pulmonary nodules (SPNs).1-4 However, some types of cancers, e.g. carcinoid tumours and bronchoalveolar carcinoma, have low FDG uptake that can give false-negative results. Many benign processes such as infection, inflammation and granulomatous diseases, especially tuberculosis (TB), present as SPNs with enhanced FDG uptake leading to false-positive findings.5,6 Since TB is more prevalent in South Africa than in developed countries, it may be anticipated that the accuracy of FDG-PET in differentiating benign from malignant SPNs will be significantly worse owing to a drop in specificity.. Over time the uptake of FDG continues to increase in malignant lesions, whereas it decreases or remains stable in benign lesions.7-9 It was therefore deduced that dual time-point imaging might further improve the accuracy of FDG-PET to distinguish ...

1. Carruba G, Stefano R, Cocciaeliferro L. Intercellular communication and human prostate carcinogenesis. Ann NY Acad Sci. 2002;963:156-68 2. Goldstein NS, Underhiel J, Roszka N, Neill JS. Cytokeratin 34 beta E-12 immunoreactivity in benign prostate acini. Quantitation, pattern assessment, and electron microscopic study. Am J Clin Pathol. 1999;112:69-74 3. Bonkhoff H, Wernert N, Dhom G, Remberger K. Basement membranes in fetal, adult normal, hyperplastic and neoplastic human prostate. Virchows Arch A Pathol Anat Histopathol. 1991;418:375-81 4. Kosir MA, Wang W, Zukowski KL, Tromp G. Degradation of basement membrane by prostate tumor heparanase. J Surg Res. 1999;81:42-7 5. Bonkhoff H, Remberger K. Morphogenesis of benign prostatic hyperplasia and prostatic carcinoma. Pathology. 1998;19:12-20 6. Bostwick DG. Prospective origins of prostate carcinoma. Prostate intraepithelial neoplasia and atypical adenomatous hyperplasia. Cancer. 1996;78:330-6 7. Haggman MJ, Macoska JA, Wojno KJ, Oesterling JE. ...

BACKGROUND: Ovine pulmonary adenocarcinoma (OPA) is a worldwide contagious bronchioalveolar carcinoma caused by infection of a beta retrovirus in sheep and less in goat. Neoplastic proliferation of type II pneumocytes and clara cells, produce papillary to acinar tumoral pattern with infiltration of macrophages, lymphocytes and plasma cells and interstitial fibrosis tissue. OBJECTIVES: This study was conducted to investigate the patterns of OPA and checking the expression of TTF1. METHODES: A total of 7952 ovine lungs were studied for macroscopic and microscopic pathology examination and so checking TTF1 marker. RESULTS: 25 cases were diagnosed as OPA that based on macroscopic and histopathologic lesions, two different classifications were defined. Tumoral lesions were divided to classic (68%) and atypic (32%) forms of OPA based on growth pattern and progression and two other forms of mucinous (56%) and non-mucinous (44%) of OPA based on histologic characterization of neoplastic secretory cells were

Looking for online definition of Lung neoplasms in the Medical Dictionary? Lung neoplasms explanation free. What is Lung neoplasms? Meaning of Lung neoplasms medical term. What does Lung neoplasms mean?

Gefitinib is superior to carboplatin-paclitaxel as an initial treatment for pulmonary adenocarcinoma among nonsmokers or former light smokers in East Asia. The presence in the tumor of a mutation of the EGFR gene is a strong predictor of a better outcome with gefitinib. (ClinicalTrials.gov number, N …

CHICAGO, IL--(Marketwired - October 30, 2014) - Lung cancer patients with minimally invasive adenocarcinoma (MIA) have similar, positive five-year disease-free survival (DFS) and overall survival (OS) rates as patients with adenocarcinoma in-situ (AIS), according to research presented today at the 2014 Chicago Multidisciplinary Symposium in Thoracic Oncology. The Symposium is...

Apoptosis is an important mechanism of malignant tumor formation and progression. Single nucleotide polymorphisms (SNPs) located within cell death genes may influence cancer risk. We explored the...

We especially have to look for the presence of areas of ground-glass opacity, air bronchograms or cavities and the three-dimensional ratios of a lesion.. With the increasingly important role of PET-CT, we have to be aware of the accuracy of PET-CT and we should have an idea about the prevalence of infectious and non-infectious granulomatous disease in the area that we practice.. ...

(a) An orthopantomogram of case 1 revealing ground-glass appearance in the left mandible and having a fusiform shape. (b) A mandibular right lateral cross-secti