TY - JOUR. T1 - Expression of Das-1 in primary lung adenocarcinomas represents reactivation of an oncofetal pulmonary antigen. AU - Deshpande, C. G.. AU - Shah, R. N.. AU - Yeldandi, A.. AU - Papreddy, K.. AU - Badve, S.. PY - 2002/12/1. Y1 - 2002/12/1. N2 - Objective: The monoclonal antibody (mAb) designated as mAb Das-1 was generated against a colonic epithelial protein. It reacts with bronchiolar epithelium and submucosal glands and weakly with alveolar lining cells of fetal lung. Adult alveolar epithelium is, however, nonreactive for mAb Das-1. The present study was designed to evaluate the immunoexpression of Das-1 and to correlate it with the histomorphology of primary lung adenocarcinomas and intestinal metaplasia. Methods: Eighty-four cases of primary lung adenocarcinomas were reviewed and categorized according to histologic grade and subtype. Immunohistochemical staining with mAb Das-1 was performed with normal colon as control. Results: Expression of Das-1 in the submucosal bronchial ...
In the present study, we demonstrated PCV and EGFR mutation status as independent prognostic factors in untreated advanced lung adenocarcinoma patients. We also showed that PCV , 2.2 ng/ml was a predictor of a favorable outcome in both advanced lung adenocarcinoma patients with wild-type and mutant EGFR.. Serum CYFRA 21-1 has been reported as a prognostic factor in patients with a variety of cancer types, including resectable NSCLC [39, 40], biliary tract cancer [41], urothelial cancer [42], head and neck cancer [43], esophageal cancer [44], and cervical cancer [45].. A meta-analysis of CYFRA 21-1 as a prognostic indicator in advanced NSCLC patients showed that the PCV may be a reliable prognostic factor [29], however, since non-adenocarcinoma accounted for 65% of the cases and squamous cell carcinoma for 50%, the role of serum CYFRA 21-1 as a prognostic indicator in the lung adenocarcinoma population remained unclear. Moreover, in a study of PCV as a prognostic indicator in advanced NSCLC ...
Licorice and its components have been reported to posses various anti-tumor activities, but its active ingredients and underlying mechanisms are not well understood yet. In the present study, a group of representative licorice-derived compounds that could be detected in rat plasma or urine were screened for anti-tumor activity. Among these compounds, isoangustone A (IAA) was found to promptly Inhibit the viability of SW480 human colorectal adenocarcinoma cells in a time- and concentration-dependent manner. Further analyses indicate that IAA activated caspase-dependent pro-apoptotic signaling and induced significant apoptosis, while had little effect on cell cycle. IAA strongly inhibited Akt phosphorylation within 5 min; however, overexpression of constitutively activated Akt could not rescue IAA-mediated inhibition, indicating that inhibition of Akt was not involved in IAA-induced apoptosis. Further examinations show that IAA induced dissipation of mitochondria membrane potential and release of ...
Previous studies have observed that carboxyl-terminal binding protein 1 (CtBP1) is highly expressed in several malignant tumors, such as breast, glioma and prostate tumors, and it was found to play a role in cancer development (5,6,9,10). However, the expression pattern and biological functions of CtBP1 in lung adenocarcinoma remain largely unknown. The present study aimed to address this by examining the expression patterns of CtBP1 in lung adenocarcinoma tissues, its correlation to clinicopathological features, and its effects on the malignant behavior of lung cancer cells. As such, it represents the first investigation of the clinical significance of CtBP1 expression in lung adenocarcinoma patients. Using IHC, we found that CtBP1 was upregulated in lung adenocarcinoma patients with lymph node metastasis. Moreover, CtBP1 expression was strongly associated with tumor differentiation, size and with poor overall survival of lung adenocarcinoma patients. These data suggest that CtBP1 may act as an ...
Cell lines are invaluable tools for biomedical research. Cancer cell lines are the foundation of cancer biology and the quest for drug treatments. Adenocarcinoma is a cancer of the epithelium (including colon) and originates in glandular tissue, such as skin surface layer and glands.. Product. These human adenocarcinoma cell lines have been previously licensed to commercial parties for research into human adenocarcinoma treatments.. These cell lines are available through Public Health England ECACC. Please make your purchase through the links below.. Imperial Innovations requests that commercial/for profit parties contact them first to discuss the terms of supply prior to Innovations authorising the release of supplies from ECACC.. ...
Gastric cancer is one of the most common malignancies worldwide. In this study, we screened for genes upregulated in gastric cancer by comparing gene expression profiles from serial analysis of gene expression and microarray and identified the palate, lung, and nasal epithelium carcinoma-associated protein (PLUNC) gene. Immunostaining for PLUNC in 140 gastric cancer cases revealed strong and extensive staining of PLUNC in hepatoid adenocarcinoma of the stomach, whereas 727777677340f conventional gastric cancer cases showed focal immunostaining of PLUNC. Gastric hepatoid adenocarcinoma is an extrahepatic tumor characterized by morphologic similarities to hepatocellular carcinoma. To investigate the utility of PLUNC immunostaining in the diagnosis of gastric hepatoid adenocarcinoma, six cases of gastric hepatoid adenocarcinoma (six primary tumors and two associated liver metastases) were studied further. PLUNC staining was observed in all six primary hepatoid adenocarcinomas. PLUNC staining was ...
BioAssay record AID 102327 submitted by ChEMBL: Cytotoxicity activity on LoVo/Dx human adenocarcinoma cell line after 1 hr of drug exposure.
TY - JOUR. T1 - Diagnostic utility of thyroid transcription factor-1 expression in adenocarcinomas presenting in serous fluids. AU - Afify, Alaa M. AU - Al-Khafaji, Basim M.. PY - 2002. Y1 - 2002. N2 - OBJECTIVE: To evaluate the diagnostic utility of the immunohistochemical expression of thyroid transcription factorr-1 (TTF-1) in adenocarcinomas from serous fluid specimens. STUDY DESIGN: Archival paraffin-embedded cell blocks of serous fluids from 82 cases, including 34 cases of metastatic lung adenocarcinoma, 12 of metastatic ovarian adenocarcinoma, 12 of metastatic breast adenocarcinoma, 12 of metastatic gastrointestinal adenocarcinoma and 12 of malignant mesothelioma, were immunostained with anti-TTF-1. All the staining was carried out using a Ventana Automated System. Staining was evaluated according to the intensity of the nuclear staining (1+ to 4+) by two observers. RESULTS: Of the metastatic lung adenocarcinomas, 79% (27/34) expressed 3+ to 4+ reactivity against TTF-1. None of the ...
Mickey, D D.; Stone, K R.; Wunderli, H; Mickey, G H.; Vollmer, R T.; and Paulson, D F., "Heterotransplantation of a human prostatic adenocarcinoma cell line in nude mice." (1977). Subject Strain Bibliography 1977. 30 ...
Adenocarcinomas metastatic to brain from lung or colon may pose differentiation difficulties. Ultrastructurally, both may have brush borders with rootlets. This study examines the ultrastructural morphology and immunohistochemical expression of villin (associated with rootlets), cytokeratin 7 (present in lung adenocarcinomas), and cytokeratin 20 (present in colon adenocarcinomas) in 19 formalin-fixed sequential surgical biopsies of lung adenocarcinomas metastatic to brain as compared to 13 colonic adenocarcinoma metastases. Of lung tumor metastases, mucinous differentiation with rootlets was most common [6/19(32%)]. All colon tumor metastases were cytokeratin 7(-), 20(+), and profusely villin(+). Well-formed rootlets were seen. All lung metastases were cytokeratin 7(+) and 20(-). 5/6(83%) lung metastases with rootlets were focally villin(+). 12/13(95%) without rootlets were villin(-). Rootlets are extremely common in lung adenocarcinoma metastatic to brain. Villin immunoreactivity closely correlates
Purpose: The microRNA-34b/c (miR-34b/c) is considered a tumor suppressor in different tumor types and a transcriptional target of TP53. The main objectives of this study were to investigate the clinical implications of miR-34b/c methylation in patients with early-stage lung adenocarcinoma and to determine the functional role of miR-34b/c re-expression in lung adenocarcinoma cell lines.. Experimental Design: Aberrant methylation and expression of miR-34b/c were assessed in 15 lung adenocarcinoma cell lines and a cohort of 140 early-stage lung adenocarcinoma. Lung adenocarcinoma cell lines were transfected with miR-34b/c and the effects upon cell proliferation, migration, invasion, and apoptosis were investigated.. Results: Aberrant methylation of miR-34b/c was detected in 6 (40%) of 15 lung adenocarcinoma cell lines and 64 of 140 (46%) primary lung adenocarcinoma. Expression of miR-34b/c was significantly reduced in all methylated cell lines and primary tumors, especially with TP53 mutations. ...
BACKGROUND/AIM AXL (anexelekto) has been explored as a potential novel therapeutic target for non-small cell lung carcinoma (NSCLC) but its activation status has not been evaluated in NSCLC. PATIENTS AND METHODS We first immunolocalized the phosphorylated form of AXL in 112 lung adenocarcinoma cases and subsequently evaluated the anti-neoplastic effects of monoclonal antibody AXL in two lung adenocarcinoma cell lines, PC9 and A549. RESULTS Phospho-AXL immunoreactivity was detected in 59.8% of adenocarcinoma cases examined and tended correlate significantly with larger tumor size (p=0.08) and with overall survival of the patients (p=0.041). Results of in vitro analysis revealed that the monoclonal antibody to AXL significantly inhibited cell proliferation of PC9 and A549, lung adenocarcinoma cell lines, which was caused by an inhibition of extracellular signal-regulated kinase (ERK) activation. CONCLUSION AXL-targeted therapy, possibly through inhibiting ERK activation of carcinoma cells, could
TY - JOUR. T1 - The impact of smoking and tp53 mutations in lung adenocarcinoma patients with targetable mutations-the lung cancer mutation consortium (LCMC2). AU - Aisner, Dara L.. AU - Sholl, Lynette M.. AU - Berry, Lynne D.. AU - Rossi, Michael R.. AU - Chen, Heidi. AU - Fujimoto, Junya. AU - Moreira, Andre L.. AU - Ramalingam, Suresh S.. AU - Villaruz, Liza C.. AU - Otterson, Gregory A.. AU - Haura, Eric. AU - Politi, Katerina. AU - Glisson, Bonnie. AU - Cetnar, Jeremy. AU - Garon, Edward B.. AU - Schiller, Joan. AU - Waqar, Saiama N.. AU - Sequist, Lecia V.. AU - Brahmer, Julie. AU - Shyr, Yu. AU - Kugler, Kelly. AU - Wistuba, Ignacio I.. AU - Johnson, Bruce E.. AU - Minna, John D.. AU - Kris, Mark G.. AU - Bunn, Paul A.. AU - Kwiatkowski, David J.. PY - 2018/3/1. Y1 - 2018/3/1. N2 - Purpose: Multiplex genomic profiling is standard of care for patients with advanced lung adenocarcinomas. The Lung Cancer Mutation Consortium (LCMC) is a multi-institutional effort to identify and treat ...
p21WAF1/CIP1 protein is a cyclin-dependent kinase inhibitor, discovered to be a downstream effector of p53-dependent cell cycle regulation. In order to elucidate the significance of p21 expression in lung adenocarcinomas, we performed immunohistochemical analysis of p21, p53 and Ki-67 expression in surgically resected lung adenocarcinomas. In non-neoplastic tissue, a few bronchial and bronchiolar suprabasal and ciliated cells, and a few type II alveolar cells and alveolar macrophages in the peripheral lung, were p21 positive, but the positive rate in normal lung tissue was very low (,1%). All 91 lung adenocarcinomas examined showed p21 immunoreactivity: 39 cases (42.9%) and 52 cases (57.1%) showed high and low p21 expression levels, respectively. There was no significant correlation between p21 expression and p53 expression, the loss of heterozygosity status of the p53 gene, histological grade determined by the predominant histology, lymph node metastasis, pathological stage, tumor size, smoking ...
Cell lines are invaluable tools for biomedical research. Cancer cell lines are the foundation of cancer biology and the quest for drug treatments. Adenocarcinoma is a cancer of the epithelium (including colon) and originates in glandular tissue, such as skin surface layer and glands.. Product. These human adenocarcinoma cell lines have been previously licensed to commercial parties for research into human adenocarcinoma treatments.. These cell lines are available through Public Health England ECACC. Please make your purchase through the links below.. Imperial Innovations requests that commercial/for profit parties contact them first to discuss the terms of supply prior to Innovations authorising the release of supplies from ECACC.. ...
BACKGROUND. The decline of gastric adenocarcinoma in the U. S. and the parallel decrease in the predominance of the intestinal type of gastric adenocarcinoma may reflect, in part, changes in diet over the last 60 years. Because the intestinal and diffuse types of gastric adenocarcinoma may be epidemiologically distinct, the authors hypothesized...
Adenocarcinoma[1] (/ˌædᵻnoʊkɑːrsᵻˈnoʊmə/; plural adenocarcinomas oradenocarcinomata /ˌædᵻnoʊkɑːrsᵻˈnoʊmᵻtə/) is a type of cancerous tumor that can occur in several parts of the body. It is defined as neoplasia of epithelial tissue that has glandularorigin, glandular characteristics, or both. Adenocarcinomas are part of the larger grouping ofcarcinomas, but are also sometimes called by more precise terms omitting the word, where these exist. Thus invasive ductal carcinoma, the most common form of breast cancer, is adenocarcinoma but does not use the term in its name-however, esophageal adenocarcinoma does to distinguish it from the other common type of esophageal cancer, esophageal squamous cell carcinoma. Several of the most common forms of cancer are adenocarcinomas, and the various sorts of adenocarcinoma vary greatly in all their aspects, so that few useful generalizations can be made about them. ...
Adenocarcinoma (/ˌædɪnoʊkɑːrsɪˈnoʊmə/; plural adenocarcinomas or adenocarcinomata /ˌædɪnoʊkɑːrsɪˈnoʊmɪtə/) is a type of cancerous tumor that can occur in several parts of the body. It is defined as neoplasia of epithelial tissue that has glandular origin, glandular characteristics, or both. Adenocarcinomas are part of the larger grouping of carcinomas, but are also sometimes called by more precise terms omitting the word, where these exist. Thus invasive ductal carcinoma, the most common form of breast cancer, is adenocarcinoma but does not use the term in its name-however, esophageal adenocarcinoma does to distinguish it from the other common type of esophageal cancer, esophageal squamous cell carcinoma. Several of the most common forms of cancer are adenocarcinomas, and the various sorts of adenocarcinoma vary greatly in all their aspects, so that few useful generalizations can be made about them. In the most specific usage (narrowest sense), the glandular origin or traits ...
This study will compare the efficacy of azacitidine versus observation in patients with pancreatic cancer at high risk of recurrence.
Introduction: Lung adenocarcinoma has a complex variety of different hystopathologic subtypes with distinct epidemiology, pathology and prognosis. Pulmonary adenocarcinoma with enteric differentiation is a rare variant defined as a tumor with more than 50% of colorrectal-like components, immunohistochemistry (IHC) positive for at least one marker of enteric differentiation (CK20, CDX-2 or MUC2) and no evidence of other malignancies. Case Series: Patients were identified in a review of a set of adenocarcinomas, apparently originated in colon, but posteriorly accessed as lung adenocarcinomas. Median age was 57.6 years, were all Caucasian subjects and presented with metastatic disease. The median size were 6.3 cm at the time of diagnosis and all had spiculated shape forms at CT scans. Microscopic description revealed a lepidic (mucinous) adenocarcinoma in all five cases. Immunohistochemistry were positive for CK20 or CDX-2 in all these cases and was negative for CK7 in one patient. Conclusion: The use of
Several SOX genes are involved in lung development and may have functional roles within the lung. SOX9 (a transcription factor) has been shown to be involved in several types of cancer. In this lab-based study, SOX9 expression was investigated in 29 lung adenocarcinoma and 28 normal lung samples using silico data mining, quantitative reverse transcription-PCR and immunohistochemistry.. SOX9 was upregulated at both the mRNA and protein level in the majority of lung adenocarcinomas compared with normal tissue. In addition, recurrent lung adenocarcinoma tissue showed significantly higher SOX9 expression than that of a primary lesion. RNA interference technique and microarray gene expression further demonstrated that knockdown of SOX9 inhibited cell growth, downregulated CDK4 and upregulated p21. These are all important cell cycle regulators and their expression could mediate SOX9-related alteration in cancer cell growth.. SOX9 may be an important biomarker in lung adenocarcinoma which could aid in ...
Despite encouraging clinical results with sorafenib monotherapy in patients with KRAS-mutant non-small-cell lung cancer (NSCLC), the overall survival benefit of this drug is limited by the inevitable development of acquired resistance. The exact mechanism underlying acquired sorafenib resistance in KRAS-mutant NSCLC is unclear. In this study, the mechanism of acquired sorafenib resistance was explored using a biologically relevant xenograft model, which was established by using the A549 human lung adenocarcinoma cell line and an in vivo-derived, sorafenib-resistant A549 subline (A549/SRFres). Results from the initial study demonstrated that sorafenib treatment significantly decreased E-cadherin (P , 0.05) levels but significantly increased matrix metallopeptidase 9 (MMP9) levels (P , 0.01) in A549/SRFres tumors, whereas expression levels of phospho-protein kinase B (AKT), phospho-focal adhesion kinase (FAK), and phospho-Src were elevated in sorafenib-treated A549 and A549/SRFres tumors. We next ...
Metastatic lung cancer is common in lung adenocarcinoma patients, but the molecular mechanisms of metastasis remain incompletely resolved. MicroRNA (miR) regulate gene expression and contribute to cancer development and progression. This report identifies miR-576-3p and its mechanism of action in lung cancer progression. miR-576-3p was determined to be significantly decreased in clinical specimens of late-stage lung adenocarcinoma. Overexpression of miR-576-3p in lung adenocarcinoma cells decreased mesenchymal marker expression and inhibited migration and invasion. Inhibition of miR-576-3p in non-malignant lung epithelial cells increased migration and invasion as well as mesenchymal markers. Serum/glucocorticoid regulated kinase 1 (SGK1) was a direct target of miR-576-3p, and modulation of miR-576-3p levels led to alterations in SGK1 protein and mRNA as well as changes in activation of its downstream target linked to metastasis, N-myc downstream regulated 1 (NDRG1). Loss of the ability of ...
Background: Tumor budding has recently been reported as an independent adverse prognostic factor for colorectal adenocarcinomas and other types of carcinoma in the digestive tract. This study aimed to evaluate the prognostic value of tumor budding in patients with early-stage cervical adenocarcinomas and any associations with other clinical and pathological features. Methods: Histological slides of patients with early-stage (IB-IIA) usual-type endocervical adenocarcinoma who underwent radical hysterectomy and pelvic lymph node dissection, without preoperative chemotherapy, between January 2006 and December 2012 were reviewed. Tumor budding was evaluated in routinely-stained sections and defined as detached single cells or clusters of fewer than 5 cells in a tumor invasive front and was stratified based on the number of bud counts in 10-high-power fields as low (follow-up outcomes were assessed. Results: Of 129 patients, a high tumor bud count was observed in 15 (11.6%), positively associated with
Background: A steep increase in the incidence of esophageal adenocarcinoma has been observed between 1973 and 2001, but recent trends have not been reported. Our aim was to examine recent trends in esophageal adenocarcinoma incidence.. Methods: We used the Surveillance Epidemiology and End Results database of the National Cancer Institute to identify all patients who were diagnosed with esophageal adenocarcinoma between 1973 and 2006. Incidence trends were analyzed for esophageal adenocarcinoma overall and by stage using joinpoint regression.. Results: Overall esophageal adenocarcinoma incidence increased from 3.6 per million in 1973 to 25.6 per million in 2006. Incidence trend analysis, however, suggests that the increase has slowed, from an 8.2% annual increase prior to 1996 to 1.3% increase in subsequent years (P = 0.03). Stage-specific trend analyses suggest that the change in overall esophageal adenocarcinoma incidence largely reflects a plateau in the incidence of early stage disease. Its ...
A macrophage-mediated antibody-dependent cellular cytotoxic reaction has been described in a syngeneic murine mammary adenocarcinoma model. The antibody appears to be present in two forms, one apparently complexed with antigen and the other identified as 7S immunoglobulin on Sephadex G-200 and as the IgG2a subclass by blocking of Fc receptors on the macrophages. This antibody is first detected in mice with regressing tumors. Tumor cells from immune mice appear to be coated with this antibody, as they are sensitive to the effects of normal macrophages in vitro, whereas tumor cells from immunologically compromised mice are not. Thus, a macrophage-dependent reaction probably is relevant in the in situ immune defenses against this tumor.. ...
The p63 gene is a recently discovered member of the p53 family located at chromosome 3q27Many studies have reported that overexpression of p63 can mimic p53 activities by binding DNA, activating transcription, and inducing apoptosis.. Various studies proved p63 as a marker of basal cells in normal salivary glands, breast, prostate, respiratory and squamous epithelia, and of tumor cells from various malignancies. Still, p63 has been the subject of relatively few studies in lung adenocarcinoma, and breast carcinoma, and no study has described the correlation of p63 with pancreatic ductal adenocarcinoma.. In the current study, we aim to evaluate the prognostic value of the expression of p63 in the lung adenocarcinoma, breast adenocarcinoma, and pancreatic ductal adenocarcinoma. We will achieve this aim by collecting clinical data retrospectively from the patients medical records as well as assessing the histological sections and performing immunohistochemical staining for p63. ...
The application of immunotherapeutic strategies that target the most potent antigen presenting cell, the dendritic cell (DC), are likely to substantially increase the magnitude of the anti-tumor immune response. Although there are issues of activation state and antigen load, mechanisms to increase the number of DCs available to the immune system are among the first steps in development of affective DC based immunotherapeutic strategies. The Central Hypothesis of our study is: Administration of Granulocyte Macrophage Colony Stimulating Factor (GM-CSF) to patients with pancreatic adenocarcinoma will result in enhance recruitment of DCs to the sentinel lymph node, into the peripheral blood, and/or tumor site. We propose performing a phase I, dose escalation, clinical trial of systemic and intra-tumoral GM-CSF administration for the treatment of pancreatic adenocarcinoma. This trial will be designed to assess toxicity and immunologic effects, principally dendritic cell recruitment. Patients with ...
Gentaur molecular products has all kinds of products like :search , US Biomax \ Lung adenocarcinoma tissue array with normal lung tissue, including TNM and pathology grade,30 cases_40 cores, replacing BC04119; ihc Anti-Actin confirmed \ BC04119b for more molecular products just contact us
Nectin-like molecule-5 (Necl-5) is an immunoglobulin (Ig)-like molecule that is up-regulated in many types of cancer cells. It was shown experimentally that Necl-5 enhances cell migration, proliferation, and metastasis, but its clinical significance has not been documented. The aim of this study was to observe the expression of Necl-5 in surgically resected primary lung adenocarcinomas and to investigate its clinical significance. A total of 63 surgically resected primary pulmonary adenocarcinoma tissues were investigated by immunohistochemistry for the expression of Necl-5. The relationship between expression of Necl-5 and clinicopathological features was analyzed, and the influence of Necl-5 expression on outcomes in these patients was assessed. A strong expression of Necl-5 by cancer cells was observed in 43 of the 63 tumors. The overexpression of Necl-5 by cancer cells was significantly associated with lymph node metastasis (P = 0.0398), TNM staging (P = 0.0367), and the bronchioloalveolar ...
BioAssay record AID 52959 submitted by ChEMBL: Antitumor activity against colon 26 murine adenocarcinoma cells expressed as percent TGI (tumor growth inhibition) at 0.0313 mg/kg i.v. compound dose.
Medical information, Adenocarcinoma of the bronchus. Definition of Adenocarcinoma of the bronchus, symptoms of Adenocarcinoma of the bronchus, treatment of Adenocarcinoma of the bronchus, and prevention of Adenocarcinoma of the bronchus. Exams and Tests Adenocarcinoma of the bronchus.
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Identification of the primary sites of metastatic adenocarcinomas is a diagnostic problem, particularly in cases of occult primary neoplasms. We studied the ultrastructural morphology of 16 metastatic adenocarcinomas that presented as effusions to establish organ-specific features that would characterize adenocarcinomas from various sites. The nine cases in which the site of the primary carcinoma was known included seven derived from the breast, one from the ovary and one from the colon. The primary site was unknown in seven cases at the time of presentation. After investigations, the primary site became known in five cases (lung, colon and appendix, one case each, and the ovary in two cases). Ultrastructurally diagnostic features could be detected in gastrointestinal, ovarian, bronchioloalveolar-cell and breast carcinomas. In gastrointestinal carcinomas, the presence of short microvilli with long rootlets was specific for the group. The lamellar inclusions of type II pneumocytes were diagnostic ...
PURPOSE: To better understand the complete genomic architecture of lung adenocarcinoma. EXPERIMENTAL DESIGN: We used array experiments to determine copy number variations and sequenced the complete exomes of the 247 lung adenocarcinoma tumor samples along with matched normal cells obtained from the same patients. Fully annotated clinical data were also available, providing an unprecedented opportunity to assess the impact of genomic alterations on clinical outcomes. RESULTS: We discovered that genomic alternations in the RB pathway are associated with significantly shorter disease-free survival in early-stage lung adenocarcinoma patients. This association was also observed in our independent validation cohort. The current treatment guidelines for early-stage lung adenocarcinoma patients recommend follow-up without adjuvant therapy after complete resection, except for high-risk patients. However, our findings raise the interesting possibility that additional clinical interventions might provide medical
TY - JOUR. T1 - Tumor volume and lymphovascular space invasion as a prognostic factor in early invasive adenocarcinoma of the cervix. AU - Murakami, Isao. AU - Fujii, Takuma. AU - Kameyama, Kaori. AU - Iwata, Takashi. AU - Saito, Miyuki. AU - Kubushiro, Kaneyuki. AU - Aoki, Daisuke. PY - 2012/6. Y1 - 2012/6. N2 - Objective: The aim of this study was to investigate the risk and recurrence of early invasive adenocarcinoma of the cervix, and to determine whether non-radical methods of management could be performed. Methods: The medical and histopathological records of 50 patients with early invasive adenocarcinoma of the cervix treated at Keio University Hospital between 1993 and 2005 were reviewed, and compared with the literature. Results: The median follow-up period was 64.3 months. The depth of stromal invasion was ≤3 mm in 33 cases and ,3 mm, but ≤5 mm in 17 cases. The horizontal spread was ≤7 mm in 25 cases and ,7 mm in 25 cases. One of the 33 cases that had tumor volumes of ≤500 mm ...
AZD9291 is a novel, irreversible epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI), which is administered orally. It has been proven effective in non-small cell lung cancer (NSCLC) patients, with both EGFR-sensitizing and EGFR T790M mutations in preclinical models. However, the potential therapeutic effects of AZD9291 combined with other modalities, including ionizing radiation, are not well understood. The presence of AZD9291 significantly increases the cell-killing effects of radiation in PC-9-IR cells with a secondary EGFR mutation (T790M), which was developed from NSCLC PC-9 cells (human lung adenocarcinoma cell with EGFR 19 exon 15 bp deletion) after chronic exposure to increasing doses of gefitinib, and in H1975 cells (human lung adenocarcinoma cell with EGFR exon 20 T790M mutation de novo), but not in PC-9 cells or in H460 cells (human lung adenocarcinoma cell with wild-type EGFR ...
TY - JOUR. T1 - Genome-wide aberrations in pancreatic adenocarcinoma. AU - Nowak, Norma J.. AU - Gaile, Daniel. AU - Conroy, Jeffrey M.. AU - McQuaid, Devin. AU - Cowell, John Kenneth. AU - Carter, Randy. AU - Goggins, Michael G.. AU - Hruban, Ralph H.. AU - Maitra, Anirban. PY - 2005/8/1. Y1 - 2005/8/1. N2 - Chromosomal instability, manifesting as copy number alterations (CNAs), is characteristic of pancreatic adenocarcinoma. We used bacterial artificial chromosome (BAC) array-based comparative genomic hybridization (aCGH) to examine the pancreatic adenocarcinoma genome for submicroscopic amplifications and deletions. Profiles of 33 samples (17 first-passage xenografts and 16 cell lines) identified numerous chromosomal regions with CNAs, including losses at 1p36.33∼p34.3, 1p13.3∼p13.2, 3p26, 3p25.2∼p22.3, 3p22.1∼p14.1, 4q28.3, 4q31, 4q35.1, 5q14.3, 6p, 6q, 8p23.3∼p12, 9p, 9q22.32∼q31.1, 13q33.2, 15q11.2, 16p13.3, 17p, 18q11.21∼q23 , 19p13.3∼p13.12, 19q13.2, 21p, 21q, and 22p, ...
Severe and longstanding reflux is a significant risk factor for oesophageal odenocarcinoma (OA). This risk may be independent of the presence of Barretts oesophagus. This article assess the proportion of outpatient referrals for OGD, which are at high risk for OA according to the Lagergren criteria and the implications for screening this group for continued surveillance. Half of those attending for OGD for reflux symptoms have a Lagergren reflux score consistent with an odds ratio 20 times that of a control population for oesophageal adenocarcinoma at 5 years ...
TY - JOUR. T1 - Histological evaluation of the effect of smoking on peripheral small adenocarcinomas of the lung. AU - Maeshima, Akiko Miyagi. AU - Tochigi, Naobumi. AU - Tsuta, Koji. AU - Asamura, Hisao. AU - Matsuno, Yoshihiro. PY - 2008/7. Y1 - 2008/7. N2 - Introduction:: As there is little information on the histologic characteristics of adenocarcinoma in smokers, we histologically examined the effect of smoking on the carcinogenesis and progression of peripheral small lung adenocarcinomas. Methods:: Two hundred thirty-six consecutive patients with peripheral adenocarcinoma of the lung 30 mm or less in diameter were studied. Prognosis, histology, and location of the adenocarcinoma were compared among patients with a Brinkman index (B.I.) of 0, 1 to 500, and more than 500. Results:: The ratio of smokers to nonsmokers was 1.4:1. The rate of carcinogenesis in the upper region of the lung (S1-3) was 1.4 times as high that in the lower region (S4-10) in smokers, but almost equal in the two ...
8.1. Germany. 8.1.1. Assumptions and Rationale. 8.1.2. Prevalent/Incident Cases of Gastric Adenocarcinoma. 8.1.3. Sub-Type Specific cases of Gastric Adenocarcinoma *…….. and More. More Details on this Report: https://brandessenceresearch.biz/Lifesciences-and-Healthcare/Gastric-Adenocarcinoma-Market/Summary. This report for Gastric Adenocarcinoma Market discovers diverse topics such as regional market scope, product market various applications, market size according to specific product, sales and revenue by region, manufacturing cost analysis, Industrial Chain, Market Effect Factors Analysis, market size forecast, and more.. https://www.marketwatch.com/press-release/cosmetics-and-fragrances-packaging-market-2019-industry-research-share-trend-global-industry-size-price-future-analysis-regional-outlook-to-2028-2019-09-05. About Us:. We publish market research reports & business insights produced by highly qualified and experienced industry analysts. Our research reports are available in a wide ...
In patients without a known history of malignancy such as ours, diagnosis of an extra-testicular metastasis on the initial ultrasound is difficult. The sonographic differential diagnosis includes other extra-testicular benign and malignant tumours. Clinical correlation is essential to enable better differentiation of malignant from benign lesions. The clinical finding of a hard scrotal mass in our patient raised concerns of malignancy, and hence surgical exploration was undertaken. The final diagnosis still depends on biopsy and pathological study. In our patient, histology and immunological studies of the scrotal wall biopsy hinted at the final diagnosis of occult gastric adenocarcinoma. Although positron emission tomography-CT may be useful for seeking an occult primary malignancy, it is not commonly used as a first-line imaging modality in patients presenting with a scrotal wall lesion. However, it could be offered to search for an underlying primary when histology shows adenocarcinoma but ...
Sialyl Lewis X-i antigen has been used as a tool for the clinical assessment of lung cancers, especially lung adenocarcinoma. However, the carbohydrate antigens including sialyl Lewis X-i antigen are also increased in some patients with non-malignant lung diseases such as IPF without coexistent malignancy.8-12 There is as yet no test to make a specific diagnosis in patients with raised levels of the antigen. When increased serum levels of the antigen are found in patients with IPF without a suspicious mass on the chest CT scan, further invasive and costly tests are often considered to rule out adenocarcinoma originating from other organs. If the core proteins of the antigen in patients with lung adenocarcinoma are not the same as those in patients with IPF, it is expected that the pattern of expression would differ on Western blotting analysis. In order to establish the specific test for a differential diagnosis we evaluated the pattern of expression of the antigen in serum samples of lung ...
TY - JOUR. T1 - Retrospective analysis of palliative chemotherapy for the patients with bladder adenocarcinoma. T2 - Korean cancer study group genitourinary and gynecology cancer committee. AU - Kim, Moon Jin. AU - Kim, Young Sam. AU - Oh, Sung Yong. AU - Lee, Suee. AU - Choi, Young Jin. AU - Seol, Young Mi. AU - Park, Min Jae. AU - Kim, Ki Hyang. AU - Park, Lee Chun. AU - Kang, Jung Hun. AU - Hwang, In Gyu. AU - Lee, Soon Il. AU - Lim, Seung Taek. AU - Kim, Hyo Song. AU - Lim, Ho Yeong. AU - Rha, Sun Young. AU - Kim, Hyo Jin. PY - 2018/3. Y1 - 2018/3. N2 - Background/Aims: Because of rarity, role of chemotherapy of bladder adenocarcinoma are still unidentified. Therefore, we performed a retrospective analysis of the clinical features and chemotherapy outcomes of bladder adenocarcinoma. Methods: Eligible patients for this retrospective analysis were initially diagnosed with bladder adenocarcinoma and presented with a clinically no other primary site of origin. The collected data included age, ...
Despite all of the advances in unraveling the molecular and biologic initiation and progression of cancer (32, 33), the knowledge of these processes in lung adenocarcinoma is still poor, resulting in little improvement in patient survival (5).. In this article, we revealed the potential of a population of human lung adenocarcinoma cells, characterized for expressing Lgr6, that are selected through the progression of the cancer and that harbor cancer stem cell-like properties. As a consequence of p53-mutating inactivation, there is a dysregulation of the balance between two pathways, the miR-17-92 family of miRNAs and the p38α kinase, that control normal homeostasis in human Lgr6+ lung stem cells. Lack of p53 leads to loss of its repressive effects on miR-17-92 cluster expression. miR-17-92 overexpression is a common feature in lung cancer. We have now shown that a miR-17-92 member, miR-19, downregulates p38α.. We have previously reported a deficiency in p38α protein in human lung cancer (20). ...
Colon and ovarian carcinomas can be difficult to distinguish histologically from each other in ovarian masses, in peritoneal carcinomatosis, and in metastases to distant lymph nodes (1, 2, 3, 4, 5, 6) . Misdiagnosis in this context may result in delayed identification of the primary lesion or misdirected clinical procedures. Misdiagnosis may also lead to inappropriate therapy because metastatic colon cancer is generally treated with 5-FU, whereas ovarian cancer is most often treated with paclitaxel and a platinum agent (11 , 12) . For patients with carcinoma of unknown primary, a number of palliative chemotherapy approaches using combinations of 5-FU, mitomycin-C, doxorubicin, and cyclophosphamide have been tried, but with limited success (8 , 34) Colorectal adenocarcinomas can generally be differentiated from other carcinomas on the basis of ultrastructural features, such as the microfilamentous cores of microvilli, apical electron dense bodies, and glycocalyceal bodies (35) . A prospective ...
TY - JOUR. T1 - Mutational analysis of EGFR and related signaling pathway genes in lung adenocarcinomas identifies a novel somatic kinase domain mutation in FGFR4. AU - Marks, Jenifer L.. AU - McLellan, Michael. AU - Zakowski, Maureen F.. AU - Lash, Alex E.. AU - Kasai, Yumi. AU - Broderick, Stephen. AU - Sarkaria, Inderpal S.. AU - Pham, Duy Khanh. AU - Singh, Bhuvanesh. AU - Miner, Tracie L.. AU - Fewell, Ginger A.. AU - Fulton, Lucinda L.. AU - Mardis, Elaine R.. AU - Wilson, Richard K.. AU - Kris, Mark G.. AU - Rusch, Valerie W.. AU - Varmus, Harold. AU - Pao, William. PY - 2007/5/9. Y1 - 2007/5/9. N2 - Background. Fifty percent of lung adenocarcinomas harbor somatic mutations in six genes that encode proteins in the EGFR signaling pathway, i.e., EGFR, HER2/ERBB2, HER4/ERBB4, PIK3CA, BRAF, and KRAS. We performed mutational profiling of a large cohort of lung adenocarcinomas to uncover other potential somatic mutations in genes of this signaling pathway that could contribute to lung ...
Lung adenocarcinoma (LA) is the most common cause of cancer-related death worldwide. Despite the advances over last decade in new targeted therapies, cancer genetics, diagnostics, staging, and surgical techniques as well as new chemotherapy and radiotherapy protocols, the death rate from LA...
Results All normal colonic mucosa showed SIRT1 expression with no exception, and 42 (80.8%) of 52 adenomatous polyps were positive for SIRT1. However, only 208 (41.9%) of 497 colorectal adenocarcinomas were positive. Moreover, 45 (35.7%) of 126 metastatic tissues were positive. Collectively, the SIRT1 expression was gradually decreased during carcinogenesis and tumour progression. The associations between SIRT1 expression and clinicopathological parameters revealed that loss of SIRT1 expression was associated with proximal tumour location, mucinous histology and defective mismatch repair protein expression. This suggests that loss of SIRT1 expression is associated with the microsatellite instability phenotype of colorectal adenocarcinoma. In survival analyses, the loss of SIRT1 expression was significantly associated with overall survival (p=0.027, log-rank test) in univariable analysis, but multivariable analysis failed to achieve significance. ...
The Korean Journal of Pathology 2011; 45: 79-86 DOI: 10.4132/KoreanJPathol.2011.45.1.79 Cytologic Features of Prostatic Adenocarcinoma in Urine: Comparison with Urothelial Carcinoma Lucia Kim ∙ Joo Young Song Suk Jin Choi ∙ In Suh Park Jee Young Han ∙ Joon Mee Kim Young Chae Chu Department of Pathology, Inha University School of Medicine, Incheon, Korea Received: March 9, 2010 Accepted: November 19, 2010 Corresponding Author Young Chae Chu, M.D. Department of Pathology, Inha University Hospital, 7-206 Sinheung-dong 3-ga, Jung-gu, Incheon 400-711, Korea Tel: +82-32-890-3984 Fax: +82-32-890-3464 E-mail: [email protected] *This study was supported by Inha University Research Grants. Background: Prostate adenocarcinoma (PACa) cells are rarely identified in urine cytology specimens and might be easily overlooked or misdiagnosed as urothelial neoplasm when clinically unsuspected. Methods: We reviewed 19 urine cytology specimens obtained from 13 patients with PACa and evaluated the characteristic ...