Recipient factors,ref,Vlaar AP, et al. Risk factors and outcome of transfusion-related acute lung injury in the critically ill: a nested case-control study. Crit Care Med. 2007;176:886,/ref,,ref,Gajic O, et al. Transfusion-related acute lung injury in the critically ill: prospective nested case-control study. Am J Respir Crit Care Med. 2007;176:886,/ref,,ref name=fifteen,Toy P, et al. Transfusion-related acute lung injury: incidence and risk factors. Blood. 2012;119:1757,/ref,,ref,Benson AB, et al. Transfusion-related acute lung injury in ICU patients admitted with gastrointestinal bleeding. Intensive Care Med. 2010;36:1710,/ref ...
Non-critically ill with TRALI - 5-7% ,ref,Looney MR, et al. Prospective study on the clinical course and outcomes in transfusion-related acute lung injury. Crit Care Med. 2014;42:1676,/ref,,ref,Popovsky MA, et al. Transfusion-related acute lung injury: a neglected serious complication of hemotherapy. Transfusion. 1992;32:589,/ref,,ref,Sillman CC, et al. Transfusion-related acute lung injury (TRALI): current concepts and misconceptions. Blood Rev. 2009;23:245,/ref ...
Data & statistics on Acute Lung Injury: MRNA expression of Interleukin-8 in bronchoalveolar lavage fluid cells before injury and after injury. NG, acute lung injury with normoglycemia group; HG, acute lung injury with hyperglycemia group; HG-VI, acute lung injury with hyperglycemia treated with intravenous insulin group; HG-AI, acute lung injury with hyperglycemia treated with aerosolized insulin group; IL-8, interleukin-8. Boxes extend ..., Particle-induced acute lung injury. Results obtained from analysis performed on bronchoalveolar lavage fluid samples recovered from animals at 24 h post-exposure. Animals were exposed by intratracheal instillation to: saline ( E); OFA100 ( C); OFA400 (P); ROFA#6 ( 1); or ARD ([). Various biomarkers of acute lung injury were assessed such as: A) edema/secretory activity (protein/mL); B) edema (albumin/mL); ..., Inhaltsverzeichnis Einleitung Hypothesen Theoretische Grundlagen der Hypothesen Patienten und Methodik Patienten Pneumonie Acute lung injury / Acute
Request for Free Sample Report: https://www.delveinsight.com/sample-request/acute-lung-injury-market. Table of Contents:. 1. Key Insights. 2. Executive Summary of Acute Lung Injury. 3. Competitive Intelligence Analysis for Acute Lung Injury. 4. Acute Lung Injury: Market Overview at a Glance. 5. Acute Lung Injury: Disease Background and Overview. 6. Patient Journey. 7. Acute Lung Injury Epidemiology and Patient Population. 8. Treatment Algorithm, Current Treatment, and Medical Practices. 9. Unmet Needs. 10. Key Endpoints of Acute Lung Injury Treatment. 11. Marketed Products. List to be continued in report. 12. Emerging Therapies. List to be continued in report. 13. Acute Lung Injury: Seven Major Market Analysis. 14. Attribute analysis. 15. 7MM: Market Outlook. 16. Access and Reimbursement Overview of Acute Lung Injury. 17. KOL Views. 18. Market Drivers. 19. Market Barriers. 20. Appendix. 21. DelveInsight Capabilities. 22. Disclaimer. 23. About DelveInsight. About DelveInsight ...
Transfusion-related acute lung injury is emerging as a common cause of transfusion-related adverse events. However, awareness about this entity in the medical fraternity is low and it, consequently, remains a very under-reported and often an under-diagnosed complication of transfusion therapy. We report a case of a 46-year old woman who developed acute respiratory and hemodynamic instability following a single unit blood transfusion in the postoperative period. Investigation results were non-specific and a diagnosis of transfusion-related acute lung injury was made after excluding other possible causes of acute lung injury. She responded to symptomatic management with ventilatory and vasopressor support and recovered completely over the next 72 hours. The diagnosis of transfusion-related acute lung injury relies on excluding other causes of acute pulmonary edema following transfusion, such as sepsis, volume overload, and cardiogenic pulmonary edema. All plasma containing blood products have been
Transfusion-Related Acute Lung Injury (TRALI) is an important life-threatening complication that is related with blood transfusion. The frequency is reported as 1/5.000. It is generally characterized with hypoxia that appears at the 2-6th hours after the blood transfusion, bilateral infiltration in the chest radiography, and non-cardiogenic pulmonary edema. Acute respiratory distress, hypotension, tachycardia and fever accompany the clinical picture. Past surgery, blood transfusion, and sepsis are among the factors that trigger the disease. In this study, the efficiency of the hemodialysis applied in the right time in the treatment of a heavy TRALI case developed after a blood transfusion has been presented.. Keywords: Acute lung injury, efficiency, hemodialysis, ...
Medical information, Acute lung injury. Definition of Acute lung injury, symptoms of Acute lung injury, treatment of Acute lung injury, and prevention of Acute lung injury. Exams and Tests Acute lung injury.
Transfusion-related acute lung injury (TRALI) is a life-threatening complication of hemotherapy. We report a series of 90 TRALI reactions in 81 patients seconda
TY - JOUR. T1 - Human immunodeficiency virus infection and hospital mortality in acute lung injury patients. AU - Mendez-Tellez, Pedro A.. AU - Damluji, Abdulla. AU - Ammerman, Douglas. AU - Colantuoni, Elizabeth. AU - Fan, Eddy. AU - Sevransky, Jonathan E.. AU - Shanholtz, Carl. AU - Gallant, Joel E.. AU - Pronovost, Peter J.. AU - Needham, Dale M.. PY - 2010/7. Y1 - 2010/7. N2 - Objective: To evaluate the impact of human immunodeficiency virus infection on hospital mortality in patients with acute lung injury and to evaluate predictors of mortality among acute lung injury patients with human immunodeficiency virus. Design, setting, and patients: Retrospective study of human immunodeficiency virus-infected patients enrolled in an ongoing prospective cohort study of acute lung injury patients conducted at 13 intensive care units in four teaching hospitals in Baltimore, Maryland. Measurements and main results: Of 520 consecutive acute lung injury patients, 66 (13%) were human immunodeficiency ...
The report titled, Acute Lung Injury Treatment Market - Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2017 - 2025 by TMR Research furnishes an in-depth analysis of the vital catalysts and deterrents of the global market for acute lung injury treatment, alongside accurate figures, charts, diagrams, and graphs. The report offers an insightful assessment of the leading geographical segments and the growth opportunities offered by each of them. Acute lung injury is a prominent cause of morbidity and mortality across the world. Since one of the common conditions that is associated with severe hypoxia is acute lung injury, acute lung injury treatment market is expected to soar as its incidence keeps escalating worldwide, augmenting mortality rates. Researchers can now have access to critical information pertaining to the pathophysiology of the condition as well as numerous biological markers related to worse clinical outcomes of patients, thanks to the recent technological ...
Ferroptosis is a newly recognized type of cell death, which is different from traditional necrosis, apoptosis or autophagic cell death. However, the position of ferroptosis in lipopolysaccharide (LPS)-induced acute lung injury (ALI) has not been explored intensively so far. In this study, we mainly analyzed the relationship between ferroptosis and LPS-induced ALI. In this study, a human bronchial epithelial cell line, BEAS-2B, was treated with LPS and ferrostatin-1 (Fer-1, ferroptosis inhibitor). The cell viability was measured using CCK-8. Additionally, the levels of malondialdehyde (MDA), 4-hydroxynonenal (4-HNE), and iron, as well as the protein level of SLC7A11 and GPX4, were measured in different groups. To further confirm the in vitro results, an ALI model was induced by LPS in mice, and the therapeutic action of Fer-1 and ferroptosis level in lung tissues were evaluated. The cell viability of BEAS-2B was down-regulated by LPS treatment, together with the ferroptosis markers SLC7A11 and GPX4,
Acute lung injury (ALI) is still a leading cause of morbidity and mortality in critically ill patients. Recently, our and other studies have found that hydrogen gas (H₂) treatment can ameliorate the lung injury induced by sepsis, ventilator, hyperoxia, and ischemia-reperfusion. However, the molecula …
Histone deacetylase (HDAC) inhibitors, developed as promising anti-tumor drugs, exhibit their anti-inflammatory properties due to their effects on reduction of inflammatory cytokines. To investigate the protective effect of butyrate, a HDAC inhibitor, on lipopolysaccharide (LPS)-induced acute lung injury (ALI) in mice. ALI was induced in Balb/c mice by intratracheally instillation of LPS (1 mg/kg). Before 1 hour of LPS administration, the mice received butyrate (10 mg/kg) orally. The animals in each group were sacrificed at different time point after LPS administration. Pulmonary histological changes were evaluated by hematoxylin-eosin stain and lung wet/dry weight ratios were observed. Concentrations of interleukin (IL)-1β and tumor necrosis factor (TNF)-α in bronchoalveolar lavage fluid (BALF) and concentrations of nitric oxide (NO) and myeloperoxidase (MPO) activity in lung tissue homogenates were measured by enzyme-linked immunosorbent assay (ELISA). Expression of nuclear factor (NF)-κB p65 in
GlobalDatas clinical trial report, Acute Lung Injury Global Clinical Trials Review, H2, 2012 provides data on the Acute Lung Injury clinical trial scenario. This report provides elemental information and data relating to the clinical trials on Acute Lung Injury. It includes an overview of the trial numbers and their recruitment status as per the site of trial conduction across the globe. The databook offers a preliminary coverage of disease clinical trials by their phase, trial status, prominence of the sponsors and also provides briefing pertaining to the number of trials for the key drugs for treating Acute Lung Injury. This report is built using data and information sourced from proprietary databases, primary and secondary research and in-house analysis by GlobalDatas team of industry experts. Note: Certain sections in the report may be removed or altered based on the availability and relevance of data for the indicated disease.
Mesenchymal stem cells (MSCs) have been shown to alleviate acute lung injury (ALI) and induce the production of regulatory dendritic cells (DCregs), but the potential link between these two cell types remains unclear. The goal of this study was to investigate the effect and mechanism of MSC-induced regulatory dendritic cells in ALI mice. In vivo experiments, C57BL/6 wild-type male mice were sacrificed at different times after intratracheal injection of LPS to observe changes in lung DC maturation and pathological damage. MSCs, DCregs or/and carboxyfluorescein diacetate succinimidyl ester (CFSE)-labeled DCs were administered to the mice by tail vein, and flow cytometry was performed to measure the phenotype of lung DCs and T cells. Lung injury was estimated by the lung wet weight/body weight ratio and histopathological analysis. In vitro, Western blotting or flow cytometry was used to detect the expression of Notch ligand or receptor in MSCs or DCs after coculture or LPS stimulation. Finally, in vivo and
The pathogenesis of hyperlactatemia during sepsis is poorly understood. We have previously described an increase in lactate concentration across the lung in the dog during early endotoxemia. Accordingly, we sought to determine if the lung releases lactate in humans and what relation this has with lung injury. Methods: We measured lactate concentrations across the lung and lung injury scores (LIS) in two groups of patients. Group 1 consisted of nine patients with acute lung injury (LIS ≤2.0) and elevated lactate concentrations (,2.0 mmol/L). Group 2 contained 12 patients with no acute lung injury (LIS scores ≤1.5), with or without increased lactate concentrations. Simultaneous measurements of plasma lactate and blood gases were obtained from indwelling arterial and pulmonary artery, catheters. Measurements of cardiac output were also obtained. Lactate measurements were done using a lactate analyzer (YSI; Yellow Springs, Ohio). Results: For each patient with acute lung injury and ...
The acute lung injury progresses as lung damage mediated by many cellular (e.g., macrophages) and humoral (e.g., chemical mediators) immunological components, which constitute a complex network to amplify inflammatory responses, leading to acute lung injury. [14] In particular, activated neutrophils are thought to play an important role in formation of the network by releasing reactive oxygen species, proteases, and cytokines. [14] These potent mediators primarily attack the endothelial and epithelial cells. In this pathway, chemotaxins including IL-8 and thromboxane B2promote accumulation of neutrophils in the lung. [33,34] In the current study, intratracheal instillation of infant formula or breast milk increased infiltration of neutrophils into the alveolar spaces as well as decreasing the peripheral leukocyte counts. These changes were less prominent in the surfactant-treated rabbits. Our observations suggest that surfactant treatment mitigated recruitment of neutrophils to the lung. ...
Bone marrow mesenchymal stem cell (BMSCs)-based therapy seems to be a promising treatment for acute lung injury, but the therapeutic effects of BMSCs transplantation on acute lung injury induced by brain ischemia and the mechanisms have not been totally elucidated. This study explores the effects of transplantation of BMSCs on acute lung injury induced by focal cerebral ischemia and investigates the underlying mechanism. Acute lung injury model was induced by middle cerebral artery occlusion (MCAO). BMSCs (with concentration of 1 × 106/ml) were transplanted into host through tail vein 1 day after MCAO. Then, the survival, proliferation and migration of BMSCs in lung were observed at 4 days after transplantation, and histology observation and lung function were assessed for 7 days. Meanwhile, in situ hybridization (ISH), qRT-PCR and western blotting were employed to detect the expression of TNF-α in lung. Neurobehavioral deficits and acute lung injury could be seen in brain ischemia rats. Implanted
TY - JOUR. T1 - Growth arrest-specific protein 6 attenuates neutrophil migration and acute lung injury in sepsis. AU - Giangola, Matthew D.. AU - Yang, Weng Lang. AU - Rajayer, Salil R.. AU - Nicastro, Jeffrey. AU - Coppa, Gene F.. AU - Wang, Ping. PY - 2013/12. Y1 - 2013/12. N2 - Sepsis is an acute inflammatory condition that can result in multiple organ failure and acute lung injury. Growth arrest-specific protein 6 (Gas6) is a broad regulator of the innate immune response involved with the nuclear factor κB signaling pathway. We hypothesized that Gas6 could have a protective role in attenuating the severity of acute lung injury and sepsis. Male mice were subjected to sepsis by cecal ligation and puncture (CLP) after which recombinant murine Gas6 (rmGas6; 5 μg/mouse) or normal saline (vehicle) was administered intravenously. Blood and lung tissues were collected at 20 h after CLP for various measurements. Treatment with rmGas6 significantly reduced serum levels of the injury markers ...
Transfusion-related acute lung injury (TRALI) is the leading cause of transfusion-associated mortality in the US. Previously, we established an immune-mediated TRALI mouse model, wherein mice with cognate antigen were challenged with MHC class I mAb. In this study, when mice housed in a rodent, specific pathogen-free barrier room were challenged with MHC I mAb, there was significant protection from TRALI compared with nonbarrier mice. Priming mice with LPS restored lung injury with mAb challenge. Using TLR4-deficient bone marrow chimeras, the priming phenotype was restricted to animals with WT hematopoietic cells, and depletion of either neutrophils or platelets was protective. Both neutrophils and platelets were sequestered in the lungs of mice with TRALI, and retention of platelets was neutrophil dependent. Interestingly, treatment with aspirin prevented lung injury and mortality, but blocking the P selectin or CD11b/CD18 pathways did not. These data suggest a 2-step mechanism of TRALI: ...
TY - JOUR. T1 - Towards prevention of acute lung injury. T2 - Frequency and outcomes of emergency department patients at-risk - A multicenter cohort study. AU - Hou, Peter C.. AU - Elie-Turenne, Marie Carmelle. AU - Mitani, Aya. AU - Barry, Jonathan M.. AU - Kao, Erica Y.. AU - Cohen, Jason E.. AU - Frendl, Gyorgy. AU - Gajic, Ognjen. AU - Gentile, Nina T.. N1 - Funding Information: The STAR Center provided internal funding (Dr. Frendl), research staff, and biostatistical support, Brigham and Womens Hospital, Boston, MA. Dr. Gajic is supported in part by grants from the National Heart, Lung, and Blood Institute HL78743-01A1; National Center for Research Resources 1 KL2 RR024151. Dr. Gentile is supported in part by grants from the National Institute of Neurological Disorders and Stroke 5U10NS059039-04. The rest of the authors have no disclosures or conflict of interest.. PY - 2012/12. Y1 - 2012/12. N2 - Background: Few emergency department (ED) evaluations on acute lung injury (ALI) have been ...
Because experimental studies have shown that intact alveolar epithelial fluid transport function is critical for resolution of pulmonary edema and acute lung injury, we measured net alveolar fluid clearance in 79 patients with acute lung injury or the acute respiratory distress syndrome. Pulmonary e …
TY - JOUR. T1 - N-acetylcysteine abrogates acute lung injury induced by endotoxin. AU - Kao, Shang Jyh. AU - Wang, David. AU - Lin, Hen I.. AU - Chen, Hsing I.. PY - 2006/1. Y1 - 2006/1. N2 - 1. Acute lung injury (ALI) or acute respiratory distress syndrome is a serious clinical problem with high mortality. N-Acetylcysteine (NAC) is an anti-oxidant and a free radical scavenger. It has been reporeted recently that NAC ameliorates organ damage induced by endotoxin (lipopolysaccharide; LPS) in conscious rats. The present study was designed to evaluate the effects of NAC on LPS-induced ALI and other changes in anaesthetized rats. 2. Sprague-Dawley rats were anaesthetized with pentobarbital (40 mg/kg, i.p.). Endotracheal intubation was performed to provide artificial ventilation. Arterial pressure and heart rate were monitored. The extent of ALI was evaluated with the lung weight (LW)/bodyweight ratio, LW gain, exhaled nitric oxide (NO) and protein concentration in bronchoalveolar lavage (PCBAL). ...
Aim To investigate the role of inhibition of the PTEN in LPS-induced acute lung injury.Methods Tirty-two male SD rats were divided into LPS group and phen + LPS group(n = 16 each),then the mortality of rats in two groups was compared.Another sixty male SD rats were divided into four groups randomly:control group(n = 6),LPS group(n = 24),phen + LPS group(n = 24),phen group(n = 6).Both LPS group and phen + LPS group were subjected to 1,3,6 h and 12 h time point subgroups after LPS administration(n = 6 each).The concentrations of protein,tumor necrosis factor-α(TNF-α) andinterleukin-6(IL-6) inbronch-oalveolar lavage fluids(BALF) were detected.The histopathologic changes of lung tissues,and the expression of p-Akt in lung tissues were also observed.Results Phen pretreatment significantly decreased the LPS-induced lethality(P 0.05).In LPS group,the protein and cytokines in BALF were significantly increased(P 0.05) and the lung tissues showed obviously inflammatory responses under light microscopy
Previous randomized trials failed to demonstrate a decrease in mortality of patients with acute lung injury treated by exogenous surfactant. The aim of this prospective randomized study was to evaluate the effects of exogenous porcine-derived surfactant on pulmonary reaeration and lung tissue in patients with acute lung injury and acute respiratory distress syndrome (ALI/ARDS). Twenty patients with ALI/ARDS were studied (10 treated by surfactant and 10 controls) in whom a spiral thoracic computed tomography scan was acquired before (baseline), 39 hours and 7 days after the first surfactant administration. In the surfactant group, 3 doses of porcine-derived lung surfactant (200 mg/kg/dose) were instilled in both lungs at 0, 12 and 36 hours. Each instillation was followed by recruitment maneuvers. Gas and tissue volumes were measured separately in poorly/nonaerated and normally aerated lung areas before and seven days after the first surfactant administration. Surfactant-induced lung reaeration was
TY - JOUR. T1 - Prehospital use of inhaled steroids and incidence of acute lung injury among patients at risk. AU - Festic, Emir. AU - Ortiz-Diaz, Enrique. AU - Lee, Augustine. AU - Li, Guangxi. AU - Kor, Daryl J.. AU - Adebola, Adesanya. AU - Akca, Ozan. AU - Hoth, Jason. AU - Levitt, Joseph E.. AU - Carter, Rickey. AU - Gajic, Ognjen. N1 - Funding Information: The work was supported in part by HL78743-01A1 , 1 KL2 RR024151 , and the Mayo Clinic Critical Care Research Committee . PY - 2013/12. Y1 - 2013/12. N2 - Purpose: Inhaled corticosteroids (ICSs) attenuated lung injury in animal studies. We investigated the association between prehospital ICS and incidence of acute lung injury (ALI) among patients at risk. Methods: In this ancillary analysis of the large multicenter Lung Injury Prediction Study cohort, we developed a propensity score for prehospital ICS use followed by matching, for all patients and for a subgroup of patients with at least 1 risk factor for direct pulmonary injury. The ...
https://doi.org/10.18632/oncotarget.20298 Kangfeng Jiang, Tao Zhang, Nannan Yin, Xiaofei Ma, Gan Zhao, Haichong Wu, Changwei Qiu, Ganzhen Deng
Linköping University, Department of Clinical and Experimental Medicine, Transfusion Medicine. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Center for Diagnostics, Department of Clinical Immunology and Transfusion Medicine. ...
The British Society for Haematology is registered in England and Wales as a Company Limited by Guarantee, No 2645706 and as a Charity, No 1005735 Registered Office and correspondence address: 100 White Lion Street London N1 9PF. Phone: 020 7713 0990 ...
Intravenous literature: Kleinman, S., Grossman, B. and Kopko, P. (2010). A national survey of transfusion-related acute lung injury risk reduction policies for platelets and plasma in the United States. Transfusion. [epub ahead of print] Abstract: BACKGROUND: Little information exists on the specific transfusion-related acute lung injury (TRALI) risk reduction practices used by multiple blood collecting…
Acute lung injury, a common condition characterized by acute severe hypoxia without evidence of hydrostatic pulmonary edema, remains a key source of mortality and morbidity in critically ill patients. The condition has a high incidence rate across the globe and overall rate of mortality remains high. Pathogenesis of the condition is explained by injuries to both the alveolar and endothelium epithelium. Recent advances in the field have helped researchers gain a better understanding of pathophysiology of the condition and several biological markers associated with worse clinical outcomes have been identified. Ongoing research in the area of fluid conservation and lung-protective ventilation strategies have demonstrated improvements in survival rate of patients. Potential treatment methods such as statin therapy and nutritional strategies are also expected to gain more focus from research bodies operating in the area of treatment of acute lung injury.. Request a sample copy of the Report @ ...
Acute lung injury (ALI) and its more severe form, acute respiratory distress syndrome (ARDS) are the leading causes of death in critical care. (LPS group) and the additional 18 rats received PFC through femoral vein prior to LPS instillation (LPS+PFC group). The rats in the control group were sacrificed 6 hours later on after saline instillation. At 2, 4 and 6 hours of exposure to LPS, 6 rats in the LPS group and 6 rats in LPS+PFC group were sacrificed at each time point. By analyzing pulmonary pathology, partial pressure of oxygen in the blood (PaO2) and lung wet-dry excess weight ratio (W/D) of each rat, we found that intravenous infusion of PFC significantly alleviated acute lung injury induced by LPS. Moreover, we BEZ235 novel inhibtior showed that the manifestation of pulmonary myeloperoxidase (MPO), intercellular adhesion molecule-1 (ICAM-1) of endothelial cells and CD11b of polymorphonuclear neutrophils (PMN) induced by LPS were significantly decreased by PFC treatment reported that ...
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Objective:Although ventilation with small tidal volumes is recommended in patients with established acute lung injury, most others receive highly variable tidal volume aimed in part at normalizing arterial blood gas values. We tested the hypothesis that acute lung injury, which develops after the in
The avian influenza virus (AIV) can cross species barriers and expand its host range from birds to mammals, even humans. Avian influenza is characterized by pronounced activation of the proinflammatory cytokine cascade, which perpetuates the inflammatory response, leading to persistent systemic inflammatory response syndrome and pulmonary infection in animals and humans. There are currently no specific treatment strategies for avian influenza. We hypothesized that mesenchymal stromal cells (MSCs) would have beneficial effects in the treatment of H9N2 AIV-induced acute lung injury in mice. Six- to 8-week-old C57BL/6 mice were infected intranasally with 1 × 104 MID50 of A/HONG KONG/2108/2003 [H9N2 (HK)] H9N2 virus to induce acute lung injury. After 30 min, syngeneic MSCs were delivered through the caudal vein. Three days after infection, we measured the survival rate, lung weight, arterial blood gas, and cytokines in both bronchoalveolar lavage fluid (BALF) and serum, and assessed pathological changes to
The avian influenza virus (AIV) can cross species barriers and expand its host range from birds to mammals, even humans. Avian influenza is characterized by pronounced activation of the proinflammatory cytokine cascade, which perpetuates the inflammatory response, leading to persistent systemic inflammatory response syndrome and pulmonary infection in animals and humans. There are currently no specific treatment strategies for avian influenza. We hypothesized that mesenchymal stromal cells (MSCs) would have beneficial effects in the treatment of H9N2 AIV-induced acute lung injury in mice. Six- to 8-week-old C57BL/6 mice were infected intranasally with 1 × 104 MID50 of A/HONG KONG/2108/2003 [H9N2 (HK)] H9N2 virus to induce acute lung injury. After 30 min, syngeneic MSCs were delivered through the caudal vein. Three days after infection, we measured the survival rate, lung weight, arterial blood gas, and cytokines in both bronchoalveolar lavage fluid (BALF) and serum, and assessed pathological changes to
TY - JOUR. T1 - Passive targeting of phosphatiosomes increases rolipram delivery to the lungs for treatment of acute lung injury. T2 - An animal study. AU - Fang, Chia Lang. AU - Wen, Chih Jen. AU - Aljuffali, Ibrahim A.. AU - Sung, Calvin T.. AU - Huang, Chun Lin. AU - Fang, Jia You. PY - 2015/7/10. Y1 - 2015/7/10. N2 - A novel nanovesicle carrier, phosphatiosomes, was developed to enhance the targeting efficiency of phosphodiesterase 4 (PDE4) inhibitor to the lungs for treating acute lung injury (ALI) by intravenous administration. Phosphatiosomes were the basis of a niosomal system containing phosphatidylcholine (PC) and distearoylphosphatidylethanolamine polyethylene glycol (DSPE-PEG). Rolipram was used as the model drug loaded in the phosphatiosomes. Bioimaging, biodistribution, activated neutrophil inhibition, and ALI treatment were performed to evaluate the feasibility of phosphatiosomes as the lung-targeting carriers. An encapsulation percentage of , 90% was achieved for rolipram-loaded ...
Stephen M. Black and a team of researchers have uncovered information that could help with treatment for acute lung injury. A summary of their study recently appeared in The Journal of Biological Chemistry, where they noted that a bacterial infection can throw off the equilibrium of two key proteins in the lungs and also put patients at risk of a highly lethal acute lung injury (ALI).. As Stephen M. Black explained in a recent press release, Bacteria can alter a single amino acid in the protein RhoA, pushing its activity level well above that of Rac1 and prompting blood vessels to leak and flood thousands of tiny air sacs in the lungs. Fortunately there might be a biological shield that is able to protect RhoA from potentially lethal alterations.. Stephen M. Black compared activation of RhoA to a rapid-fire gun that does not require the operator to pause and reload. As he explained, Activation of RhoA is an early, early event and it is a pathological activation. The cell cannot regulate it ...
TY - JOUR. T1 - Acute lung injury and nutritional support. AU - Gasperino, James. AU - Kvetan, Vladimir. PY - 2006/4/1. Y1 - 2006/4/1. KW - Acute lung injury. KW - Anti-oxidants. KW - Enteral feeding. KW - Fish oil. KW - Mechanical ventilation. UR - http://www.scopus.com/inward/record.url?scp=33645802011&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=33645802011&partnerID=8YFLogxK. U2 - 10.1097/01.CCM.0000208328.77128.C1. DO - 10.1097/01.CCM.0000208328.77128.C1. M3 - Editorial. C2 - 16550085. AN - SCOPUS:33645802011. VL - 34. SP - 1265. EP - 1267. JO - Critical Care Medicine. JF - Critical Care Medicine. SN - 0090-3493. IS - 4. ER - ...
(Health-NewsWire.Net, March 24, 2020 ) Market Overview The Global Acute Lung Injury Market is expected to grow at a CAGR of 5.8% during the forecasting period (2019-2026). Acute lung injury is a severe condition caused by acute hypoxemic respiratory failure. It is a crucial source of mortality a
Press Release issued May 28, 2014: Reportstack, provider of premium market research reports announces the addition of Acute Lung Injury - Pipeline Review, H1 2014 market report to its offering Acute Lung Injury - Pipeline Review, H1 2014
Acute lung injury complicates approximately 25-30% of subjects undergoing oesophagectomy. Experimental studies suggest that treatment with beta agonists may prevent the development of acute lung injury by decreasing inflammatory cell infiltration, activation and inflammatory cytokine release, enhancing basal alveolar fluid clearance and improving alveolar capillary barrier function.The Beta Agonist Lung Injury TrIal (prevention) is a multi-centre, randomised, double blind, placebo-controlled trial. The aim of the trial is to determine in patients undergoing elective transthoracic oesphagectomy, if treatment with inhaled salmeterol 100 mcg twice daily started at induction of anaesthesia and continued for 72 hours thereafter compared to placebo affect the incidence of early acute lung injury and other clinical, resource and patient focused outcomes. The primary outcome will be the development of acute lung injury within 72 hours of oesophagectomy. The trial secondary outcomes are the development of acute
TY - JOUR. T1 - Transfusion-related acute lung injury following random donor platelet transfusion. T2 - A report of two cases. AU - Ramanathan, Ramesh K.. AU - Triulzi, Darrell J.. AU - Logan, Theodore F.. PY - 1997/1/1. Y1 - 1997/1/1. N2 - Objectives: Transfusion-related acute lung injury (TRALI) following random donor platelet (RDP) transfusion is a rare complication of transfusion without any well-documented case reported in the English language literature. We describe 2 patients in whom TRALI occurred following RDP transfusion. Methods: Conventional clinical and laboratory methods. Results: Both patients developed acute shortness of breath 30-60 min after completion of RDP transfusion and required mechanical ventilatory support. Chest X-ray (CXR) in both cases revealed bilateral pulmonary infiltrates. Patient 1 required vasopressors for hypotension. Right heart catheterization ruled out fluid overload. Patient 2 remained hemodynamically stable. Both patients improved rapidly with continued ...
ALI/ARDS is a life-threatening condition that involves inflammation of the lungs and fluid accumulation in the air sacs, which leads to low blood oxygen levels and respiratory failure. Common causes include pneumonia, septic shock, and lung trauma. Symptoms usually develop within 24 to 48 hours of the original injury or illness, and most patients require immediate care in an intensive care unit (ICU). The main form of treatment for ALI/ARDS is the delivery of oxygen and a continuous level of pressure to the damaged lungs through mechanical ventilation. Past research has shown that lower tidal volume ventilation (LTVV), a protective ventilator management technique in which lower volumes of oxygen are administered, improves short-term clinical outcomes in individuals with ALI/ARDS. However, the long-term impact of LTVV remains unknown. The purpose of this study is to evaluate the effects of LTVV on long-term outcomes in individuals with ALI/ARDS.. This study will enroll individuals admitted to an ...
ALI/ARDS is a life-threatening condition that involves inflammation of the lungs and fluid accumulation in the air sacs, which leads to low blood oxygen levels and respiratory failure. Common causes include pneumonia, septic shock, and lung trauma. Symptoms usually develop within 24 to 48 hours of the original injury or illness, and most patients require immediate care in an intensive care unit (ICU). The main form of treatment for ALI/ARDS is the delivery of oxygen and a continuous level of pressure to the damaged lungs through mechanical ventilation. Past research has shown that lower tidal volume ventilation (LTVV), a protective ventilator management technique in which lower volumes of oxygen are administered, improves short-term clinical outcomes in individuals with ALI/ARDS. However, the long-term impact of LTVV remains unknown. The purpose of this study is to evaluate the effects of LTVV on long-term outcomes in individuals with ALI/ARDS.. This study will enroll individuals admitted to an ...
An attempt to validate the modification of the American-European consensus definition of acute lung injury/acute respiratory distress syndrome by the Berlin definition in a university hospital ...
Transfusion-related acute lung injury (TRALI) is defined as noncardiogenic pulmonary edema temporally related to the transfusion of blood products. We present a patient who, while undergoing orthotopic liver transplantation, developed acute pulmonary edema within minutes of administration of fresh frozen plasma (FFP).
References 1. Ashbaugh DG, Bigelow DB, Petty TL et al. Acute Respiratory Distress in Adults. Lancet. 1967; 2: 319-3232. Murray JF, Matthay MA, Luce JM et al. An expanded definition of the adult respiratory distress syndrome. Am Rev Respir Dis. 1988; 138: 720-7233. Bernard GR, Artigas A, Brigham KL et al. The American-European Consensus Conference on ARDS. Definitions, mechanisms, relevant outcomes and clinical trial coordination. Am. J. Respir. Crit. Care Med. 1994 Mar; 149 (3 Pt 1): 818-8244. Rubenfeld GD, Herridge MS. Epidemiology and Outcomes of Acute Lung Injury. Chest. 2007; 131 (2): 554-5625. McCallum NS, Evans TW. Epidemiology of Acute Lung Injury. Current Opinion in Critical Care. 2005: 11; 43-496. Rubenfeld GD, Caldwell E, Peabody E et al. Incidence and outcomes of acute lung injury. N Engl J Med 2005; 353: 1685-16937. Finney SJ, Evans TW. Acute lung injury outside the ICU: a significant problem. Critical Care. 2007; 11: 1698. Hudson LD, Milberg JA, Anardi D et al. Clinical risks for ...
The main pathogenesis of acute lung injury induced by haemorrhagic shock is inflammation. BML-111, a lipoxinA(4)-receptor agonist, promotes acute inflammatory resolution. We sought to elucidate whether BML-111 protects haemorrhagic shock-induced acute lung injury in rats. Thirty two adult male rats were randomized to sham group (sham), haemorrhagic shock/resuscitation (HS), HS plus BML-111 (BML-111), and HS plus BML-111 and BOC-2 (BOC-2). Haemorrhagic shock was induced by blood drawing, and then resuscitation was obtained by infusion of shed blood and two-fold volume saline. Histological findings, as well as assays of neutrophilic infiltration (myeloperoxidase activity, ICAM-1 expression), inflammatory cytokines and pro-inflammatory factor (IκB-α and NF-κB p65) confirmed that haemorrhagic shock induced acute lung injury. BML-111 significantly mitigated acute lung injury induced by haemorrhagic shock. However, BOC-2, an antagonist of the lipoxinA(4)-receptor, partially reversed the protective ...
1. Gervais HW, Eberle B, Konietzke D, Hennes HJ, Dick W, Comparison of blood gases of ventilated patients during transport. Critical Care Medicine 1987;15:761-763.. 2. Weiss, Steven J., et al. Automatic Transport Ventilator Versus Bag Valve In The EMS Setting: A Prospective, Randomized Trial. Southern Medical Journal 98.10 (2005): 970-976.. 3. Slutsky AS, Ranieri VM. Ventilator-induced lung injury. N Engl J Med. 2013 Nov 28;369(22):2126-36.. 4. Gattinoni L, Tonetti T, Cressoni M, Cadringher P, Herrmann P, Moerer O, Protti A, Gotti M, Chiurazzi C, Carlesso E, Chiumello D, Quintel M. Ventilator-related causes of lung injury: the mechanical power. Intensive Care Med. 2016 Oct;42(10):1567-75.. 5. The Acute Respiratory Distress Syndrome Network: Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. N Engl J Med 2000, 342:1301-1308.. 6. Putensen C, Theuerkauf N, Zinserling J, Wrigge H, Pelosi P. ...
Pseudomonas aeruginosa is the most common gram-negative pathogen causing pneumonia in immunocompromised patients. Acute lung injury induced by bacterial exoproducts is associated with a poor outcome in P. aeruginosa pneumonia. The major pathogenic toxins among the exoproducts of P. aeruginosa and the mechanism by which they cause acute lung injury have been investigated: exoenzyme S and co-regulated toxins were found to contribute to acute lung injury. P. aeruginosa secretes these toxins through the recently defined type III secretion system (TTSS), by which gram-negative bacteria directly translocate toxins into the cytosol of target eukaryotic cells. TTSS comprises the secretion apparatus (termed the injectisome), translocators, secreted toxins, and regulatory components. In the P. aeruginosa genome, a pathogenic gene cluster, the exoenzyme S regulon, encodes genes underlying the regulation, secretion, and translocation of TTSS. Four type III secretory toxins, namely ExoS, ExoT, ExoU, and ...
This study by the Acute Respiratory Distress Syndrome Network supports the use of low tidal volumes in acute lung injury and ARDS, and is consistent with a previous trial.1 It differs from 3 previous negative trials2-4 by having a larger difference in tidal volumes between groups, and by having a more aggressive approach to correcting acidosis. This study provides important information about tidal volume size; however, further research is still needed to determine the importance of concurrent strategies such as positive end expiratory pressure (PEEP).. In this study, an equation based on sex and height was used to calculate a predicted body weight, which was then used to set tidal volumes. Obesity is a common problem; the use of measured body weight can inadvertently lead to the use of high tidal volume ventilation. Tidal volumes should be based on ideal versus measured body weight.. This information is relevant to nurses who care for mechanically ventilated patients. Through continuous ...
The aim of present study was to evaluate the protective effects of dexmedetomidine (DEX) on lipopolysaccharide (LPS)-induced acute lung injury (ALI) and investigate its possible mechanisms mediated by HMGB1. In vivo, pulmonary pathology observation and myeloperoxidase (MPO) activity were also examined to evaluate the protective effect of DEX in the lungs. Tumour necrosis factor-α (TNF-α), interleukin-6 (IL-6) and interleukin-1β (IL-1β) in bronchoalveolar lavage fluid (BALF), serum and lung tissues LPS-induced rats were detected. The oxidative indices including superoxide dismutase (SOD), Malondialdehyde (MDA), and glutathione peroxidase (GSH-Px) in serum were also determined. Additionally, nitric oxide (NO), TNF-α, IL-6 and IL-1β, MDA, SOD and GSH-Px in the supernatants of LPS-induced BEAS-2B cells were measured. Furthermore, we detected the protein expression of high mobility group box-1 protein (HMGB1), Toll-like receptor 4 (TLR4), myeloid differentiating factor 88 (MyD88), inhibitor of ...
TY - CHAP. T1 - ROS signaling in the pathogenesis of Acute Lung Injury (ALI) and Acute Respiratory Distress Syndrome (ARDS). AU - Kellner, Manuela. AU - Noonepalle, Satish. AU - Lu, Qing. AU - Srivastava, Anup. AU - Zemskov, Evgeny. AU - Black, Stephen M.. PY - 2017/1/1. Y1 - 2017/1/1. N2 - The generation of reactive oxygen species (ROS) plays an important role for the maintenance of cellular processes and functions in the body. However, the excessive generation of oxygen radicals under pathological conditions such as acute lung injury (ALI) and its most severe form acute respiratory distress syndrome (ARDS) leads to increased endothelial permeability. Within this hallmark of ALI and ARDS, vascular microvessels lose their junctional integrity and show increased myosin contractions that promote the migration of polymorphonuclear leukocytes (PMNs) and the transition of solutes and fluids in the alveolar lumen. These processes all have a redox component, and this chapter focuses on the role played ...
Hintergrund: Beatmungsassoziierte Lungenschädigung (VILI; Ventilator-induced lung injury) trägt wesentlich zur Mortalität und Morbidität von Patienten mit Lungenversagen (ALI/ARDS, Acute Lung injury/Acute respiratory distress syndrome) bei. „Lungenprotektive Beatmung ist bis dato die einzige Intervention, die Mortalität bei ARDS nachweislich senkt. Jedoch kommt es auch unter lungenprotektiver Beatmung, insbesondere in vorgeschädigten Lungen wie bei Sepsis oder Pneumonie, zum Auftreten von VILI. 30-45 % aller Patienten mit ALI/ARDS entwickeln dieses auf dem Boden einer Pneumonie oder pneumogenen Sepsis. Zusätzlich zur protektiven Beatmung könnten neue adjuvante pharmakologische Therapiestrategien die beatmungsassoziierte Lungenschädigung weiter limitieren. In dieser Arbeit wurden Adrenomedullin und Simvastatin hinsichtlich eines protektiven Effektes gegenüber VILI untersucht. Adrenomedullin ist ein endogenes Peptid mit stabilisierenden Effekten auf die endotheliale Barrierefunktion, ...
TY - JOUR. T1 - Acute lung injury. T2 - A clinical and molecular review. AU - Butt, Yasmeen. AU - Kurdowska, Anna. AU - Allen, Timothy Craig. N1 - Copyright: Copyright 2017 Elsevier B.V., All rights reserved.. PY - 2016/4. Y1 - 2016/4. N2 - Context.-Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are a continuum of lung changes arising from a wide variety of lung injuries, frequently resulting in significant morbidity and frequently in death. Research regarding the molecular pathophysiology of ALI/ ARDS is ongoing, with the aim toward developing prognostic molecular biomarkers and molecular-based therapy. Objective.-To review the clinical, radiologic, and pathologic features of ALI/ARDS; and the molecular pathophysiology of ALI/ARDS, with consideration of possible predictive/prognostic molecular biomarkers and possible molecular-based therapies. Data Sources.-Examination of the English-language medical literature regarding ALI and ARDS. Conclusions.-ARDS is primarily a ...
Although the etiology of TRALI has not been fully delineated, two hypotheses have been postulated. The antibody-mediated hypothesis proposes that antibodies react with a corresponding antigen triggering capillary leak. Identified antibodies include antibodies to human leukocyte antigen (HLA) class I and II antigens and human neutrophil antigen (HNA). In this hypothesis, antibodies bind to recipient neutrophils. The antibody bound neutrophils are then sequestered in the lungs where activation of complement results in endothelial damage, capillary leak, and ALI. In most of these cases, the antibody is found in the donor with the corresponding antigen identified on the recipients neutrophils. Most donors associated with cases of TRALI are multiparous women who become alloimmunized during pregnancy. One notable case supporting the antibody mediated hypothesis describes a patient who underwent lung transplantation and developed dyspnea and hypoxia after receiving a transfusion of two units of packed ...
TY - JOUR. T1 - Soluble CD40 ligand accumulates in stored blood components, primes neutrophils through CD40, and is a potential cofactor in the development of transfusion-related acute lung injury. AU - Khan, Samina Yasmin. AU - Kelher, Marguerite R.. AU - Heal, Joanna M.. AU - Blumberg, Neil. AU - Boshkov, Lynn K.. AU - Phipps, Richard. AU - Gettings, Kelly F.. AU - McLaughlin, Nathan J.. AU - Silliman, Christopher C.. N1 - Copyright: Copyright 2008 Elsevier B.V., All rights reserved.. PY - 2006/10/1. Y1 - 2006/10/1. N2 - Transfusion-related acute lung injury (TRALI) is a form of posttransfusion acute pulmonary insufficiency that has been linked to the infusion of biologic response modifiers (BRMs), including antileukocyte antibodies and lipids. Soluble CD40 ligand (sCD40L) is a platelet-derived proinflammatory mediator that accumulates during platelet storage. We hypothesized that human polymorphonuclear leukocytes (PMNs) express CD40, CD40 ligation rapidly primes PMNs, and sCD40L induces ...
TY - JOUR. T1 - Extracellular superoxide dismutase haplotypes are associated with acute lung injury and mortality. AU - Arcaroli, John J.. AU - Hokanson, John E.. AU - Abraham, Edward. AU - Geraci, Mark. AU - Murphy, James R.. AU - Bowler, Russell P.. AU - Dinarello, Charles A.. AU - Silveira, Lori. AU - Sankoff, Jeff. AU - Heyland, Daren. AU - Wischmeyer, Paul. AU - Crapo, James D.. PY - 2009/1/15. Y1 - 2009/1/15. N2 - Rationale: Extracellular superoxide dismutase (EC-SOD) is a potent antioxidant that plays an important role in controlling oxidant-mediated stress and inflammation. High levels of EC-SOD are found in the lung. Acute lung injury (ALI) frequently occurs in patients with infection, and levels of EC-SOD have been shown to modulate severity of lung injury in transgenic animal models of endotoxemia-induced ALI. An R213G single nucleotide polymorphism (SNP) has been shown to alter levels of EC-SOD and patient outcomes in chronic obstructive pulmonary disease (COPD) and ischemic heart ...
TY - JOUR. T1 - An alternative method of acute lung injury classification for use in observational studies. AU - Shah, Chirag V.. AU - Lanken, Paul N.. AU - Localio, A. Russell. AU - Gallop, Robert. AU - Bellamy, Scarlett. AU - Ma, Shwu Fan. AU - Flores, Carlos. AU - Kahn, Jeremy M.. AU - Finkel, Barbara. AU - Fuchs, Barry D.. AU - Garcia, Joe G.N.. AU - Christie, Jason D.. N1 - Funding Information: Funding/Support: This work was supported by the National Institutes of Health [Grants P50HL60290, HL079063, T32 HL07891 ] and EMER07/001 . PY - 2010/11/1. Y1 - 2010/11/1. N2 - Background: In observational studies using acute lung injury (ALI) as an outcome, a spectrum of lung injury and difficult-to-interpret chest radiographs (CXRs) may hamper efforts to uncover risk factor associations. We assessed the impact of excluding patients with difficult-to-classify or equivocal ALI diagnosis on clinical and genetic risk factor associations for ALI after trauma. Methods: This study was of a prospective ...
This study was accepted to be presented for an award at the 25th Argentine Congress of Intensive Therapy. In December, 2015, this study received the 2015 Award for Best Scientific Study from the Sanatorio Anchorena Teaching and Research Committee. Conflict of interest: The authors declare that there is no conflict of interest associated with this publication. Bibliography 1. The Acute Respiratory Distress Syndrome Network. Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. N Engl J Med 2000; 342: 1301-1308. 2. Protti A, Cressoni M, Santini A, et al. Lung stress and strain during mechanical ventilation: any safe threshold? Am J Respir Crit Care Med 2011; 183: 1354-1362. 3. Brochard L, Rauss A, Benito S, et al. Comparison of three methods of gradual withdrawal from ventilatory support during weaning from mechanical ventilation. Am J Respir Crit Care Med 1994; 150: 896-903. 4. Esteban A, Frutos F, ...
Biphasic positive airway pressure (BIVENT) is a partial support mode that employs pressure-controlled, time-cycled ventilation set at two levels of continuous positive airway pressure with unrestricted spontaneous breathing. BIVENT can modulate inspiratory effort by modifying the frequency of controlled breaths. Nevertheless, the optimal amount of inspiratory effort to improve respiratory function while minimizing ventilator-associated lung injury during partial ventilatory assistance has not been determined. Furthermore, it is unclear whether the effects of partial ventilatory support depend on acute lung injury (ALI) etiology. This study aimed to investigate the impact of spontaneous and time-cycled control breaths during BIVENT on the lung and diaphragm in experimental pulmonary (p) and extrapulmonary (exp) ALI. This was a prospective, randomized, controlled experimental study of 60 adult male Wistar rats. Mild ALI was induced by Escherichia coli lipopolysaccharide either intratracheally (ALIp) or
TY - JOUR. T1 - Functional genomic assessment of phosgene-induced acute lung injury in mice. AU - Leikauf, George D.. AU - Concel, Vincent J.. AU - Bein, Kiflai. AU - Liu, Pengyuan. AU - Berndt, Annerose. AU - Martin, Timothy M.. AU - Ganguly, Koustav. AU - Jang, An Soo. AU - Brant, Kelly A.. AU - Dopico, Richard A.. AU - Upadhyay, Swapna. AU - Cario, Clinton. AU - Peter Di, Y. P.. AU - Vuga, Louis J.. AU - Kostem, Emrah. AU - Eskin, Eleazar. AU - You, Ming. AU - Kaminski, Naftali. AU - Prows, Daniel R.. AU - Knoell, Daren L.. AU - Fabisiak, James P.. PY - 2013/9/1. Y1 - 2013/9/1. N2 - In this study, a genetically diverse panel of 43 mouse strains was exposed to phosgene and genome-wide association mapping performed using a high-density single nucleotide polymorphism (SNP) assembly. Transcriptomic analysis was also used to improve the genetic resolution in the identification of genetic determinants of phosgene-induced acute lung injury (ALI). We prioritized the identified genes based on whether ...
Dive into the research topics of ROS signaling in the pathogenesis of Acute Lung Injury (ALI) and Acute Respiratory Distress Syndrome (ARDS). Together they form a unique fingerprint. ...
Authors: Wang, Bing , Wu, Bin , Ran, Yan-Ni Article Type: Research Article Abstract: OBJECTIVE: This study aims to explore whether positive end-expiratory pressure (PEEP) guided by esophageal pressure is better than the acute respiratory distress syndrome network (ARDSNet) during the treatment of traumatic acute respiratory distress syndrome (ARDS) patients. SUGGESTIONS: The use of the oxygenation method of inhaled oxygen concentration titration PEEP is suggested. METHODS: This study takes traumatic ARDS patients as the research object. The data of 23 patients were included in this study. The patients were randomly divided into two groups: the esophageal pressure titration PEEP group (n = …12), and the ARDSNet (PEEP-FiO 2 table) titration PEEP group (n = 11). All patients were given mechanical ventilation, and changes in oxygenation index, respiratory mechanics, hemodynamics and inflammatory reaction index were recorded when titrating the best PEEP with the two methods on the current day of ...
ARDSNET STUDY PDF - Low tidal volume, low pressure. The Acute Respiratory Distress Syndrome Network. Ventilation with lower tidal volumes as compared with traditional tidal.
ARDSNET STUDY PDF - Low tidal volume, low pressure. The Acute Respiratory Distress Syndrome Network. Ventilation with lower tidal volumes as compared with traditional tidal.
Treatment of acute lung injury (ALI) and its most severe form, acute respiratory distress syndrome (ARDS), remain unsolved problems of intensive care medicine. ALI/ARDS are characterized by lung edema due to increased permeability of the alveolar-capillary barrier and subsequent impairment of arterial oxygenation. Lung edema, endothelial and epithelial injury are accompanied by an influx of neutrophils into the interstitium and broncheoalveolar space. Hence, activation and recruitment of neutrophils are regarded to play a key role in progression of ALI/ARDS. Neutrophils are the first cells to be recruited to the site of inflammation and have a potent antimicrobial armour that includes oxidants, proteinases and cationic peptides. Under pathological circumstances, however, unregulated release of these microbicidal compounds into the extracellular space paradoxically can damage host tissues. This review focuses on the mechanisms of neutrophil recruitment into the lung and on the contribution of neutrophils
The overall aim of the present thesis was to study aspects of patient safety in critically ill patients with special focus on airway management, respiratory complications and nursing procedures. Study I describes a method called pharyngeal oxygen administration during intubation in an experimental acute lung injury model. The study showed that pharyngeal oxygenation prevented or considerably increased the time to life-threatening hypoxemia at shunt fractions by at least up to 25% and that this technique could be implemented in airway algorithms for the intubation of hypoxemic patients. In study II, we investigated short-term disconnection of the expiratory circuit from the ventilator during filter exchange in critically ill patients. We demonstrated that when using pressure modes in the ventilator, there was no indication of any significant deterioration in the patients lung function. A bench test suggests that this result is explained by auto-triggering with high inspiratory flows during the ...
Today we will be discussing TRALI, or transfusion-related acute lung injury. TRALI accounts for almost half of all transfusion-related fatalities in the United States.. Although several mechanisms exist, one of the major causes of TRALI is donor antibodies to white blood cells, such as human leukocyte antigen and human neutrophil antigen, or commonly referred to as HLA and HNA.. Dr. AuBuchon who wrote an editorial in TRANSFUSION comments:. Blood collectors in the United States have taken steps over the last half-dozen years to reduce the risk of TRALI through plasma, and, in many cases, also apheresis platelets. This has primarily involved women who have previously been pregnant, either deferring the use of their plasma or testing them to identify those lacking HLA antibodies. These steps have resulted in a reduction of TRALI risk by about three-quarters.. Dr. Vandekerckhove and his colleagues in Belgium screened 77 male plateletpheresis donors with a history of transfusions and 942 female ...
Background: Acute lung injury is an important cause of respiratory failure in the critically ill patient. It is caused by damage to the alveolar barrier with subsequent alveolar flooding leading to the development of refractory hypoxaemia. beta Agonists stimulate alveolar fluid clearance in animal models of lung injury. In a clinical trial (BALTI-1), intravenous beta agonists reduced extravascular lung water, an effect that took 72 h in contrast with what animal studies suggest. One possible explanation for the delay in change in extravascular lung water is the time required for salbutamol to stimulate alveolar epithelial repair ...
Research outputs, collaborations and relationships for Acute Lung Injury (ALI) / Adult Respiratory Distress Syndrome (ARDS) Center of Excellence, Pitt published between 1 June 2019 - 31 May 2020 as tracked by the Nature Index.
TY - JOUR. T1 - Simvastatin attenuates vascular leak and inflammation in murine inflammatory lung injury. AU - Jacobson, Jeffrey R.. AU - Barnard, Joseph W.. AU - Grigoryev, Dmitry N.. AU - Ma, Shwu Fan. AU - Tuder, Rubin M.. AU - Garcia, Joe G N. PY - 2005/6. Y1 - 2005/6. N2 - Therapies to limit the life-threatening vascular leak observed in patients with acute lung injury (ALI) are currently lacking. We explored the effect of simvastatin, a 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibitor that mediates endothelial cell barrier protection in vitro, in a murine inflammatory model of ALL C57BL/6J mice were treated with simvastatin (5 or 20 mg/kg body wt via intraperitoneal injection) 24 h before and again concomitantly with intratracheally administered LPS (2 μg/g body wt). Inflammatory indexes [bronchoalveolar lavage (BAL) myeloperoxidase activity and total neutrophil counts assessed at 24 h with histological confirmation] were markedly increased after LPS alone but significantly ...
Acute lung injury (ALI) is a prevalent and devastating condition in the intensive care unit. Although pulmonary artery catheters (PAC) provide clinicians with important data about a patients haemodynamic status, doubts about their clinical benefit and worries about safety have raised questions about their usefulness. This study was designed to address this issue, with 1000 patients recruited in 20 North American centres. Patients were recruited after being diagnosed with ALI and were managed haemodynamically according to a standardised management protocol. 513 patients were randomised to have a PAC and 487 to have a standard central venous catheter (CVC).. Both the PAC and CVC groups had similar rates of death during the first 60 days (27.4% and 26.3% respectively, p = 0.69). Mean (SE) ventilator-free days were also similar (13.2 (0.5) and 13.5 (0.5), p = 0.58), as were the number of days not spent in the intensive care unit up to day 28 (12.0 (0.4) and 12.5 (0.5), p = 0.40). Using a PAC did ...
Acute respiratory distress syndrome (ARDS) is a life threatening respiratory failure due to lung injury from a variety of precipitants. Pathologically ARDS is characterised by diffuse alveolar damage, alveolar capillary leakage, and protein rich pulmonary oedema leading to the clinical manifestation of poor lung compliance, severe hypoxaemia, and bilateral infiltrates on chest radiograph. Several aetiological factors associated with the development of ARDS are identified with sepsis, pneumonia, and trauma with multiple transfusions accounting for most cases. Despite the absence of a robust diagnostic definition, extensive epidemiological investigations suggest ARDS remains a significant health burden with substantial morbidity and mortality. Improvements in outcome following ARDS over the past decade are in part due to improved strategies of mechanical ventilation and advanced support of other failing organs. Optimal treatment involves judicious fluid management, protective lung ventilation with ...
The Acute Lung Injury (ALI) Center of Excellence, under the direction of Rama Mallampalli, MD, is focused on the investigation of fundamental mechanisms underlying the development and repair of lung injury, and the translational and clinical implications. The program utilizes state-of-the-art tools in molecular, biochemical, translational, and clinical investigation. Investigators within the Center are supported by the National Institutes of Health through 12 R01 grants and a Program Project Grant, by the Department of Veterans Affairs with two VA Merit awards, and by several philanthropic societies through seven investigator-initiated grant awards. Collaborative interactions exist with investigators in the Departments of Anesthesiology, Critical Care Medicine, Environmental and Occupational Health, Pathology, and Surgery. In addition to cutting-edge basic and translational science, investigators in the Center are currently establishing and participating in clinical trials with mesenchymal stem ...
Severe trauma, caused by flame burn and smoke (B + S) inhalation induces acute lung injury (ALI) and results in the loss of pulmonary function. A cascade of molecular and cellular events initiates the formation of reactive oxygen/nitrogen species (ROS/RNS) that in turn drives an inflammatory response and consequently cell death through hyper-activation of poly (ADP-ribose) polymerase (PARP-1). The purpose of this study was to investigate and counteract pulmonary dysfunction associated with nitrosative stress generated after B + S inhalation injury in an ovine and murine model of ALI. \r\nIn our time course experiment, sheep were sacrificed at 4, 8, 12, 18 and 24 hours post B + S injury. From 4 through 24 hours, there was a progressive increase in airway obstruction and lung edema formation. Furthermore, injury was associated with increased ROS/RNS generation, pro-inflammatory cytokine expression and neutrophil accumulation. Additionally, PARP-1 enzymatic activity increased in parallel with ...