TY - JOUR. T1 - Mortality in Acute Cerebral Infarction in Young Adults-A Ten-Year Experience. AU - Biller, José. AU - Adams, Harold P.. AU - Bruno, Askiel. AU - Love, Betsy B.. AU - Marsh, E. Eugene. PY - 1991/1/1. Y1 - 1991/1/1. N2 - We reviewed the one-month mortality among 213 patients aged fifteen to forty-five years (mean thirty-five) with acute cerebral infarction (CI) evaluated during the period July 1, 1977, to February 1, 1988. Atherosclerotic cerebral infarction (ACI) was diagnosed in 59 (27.7%) patients, 53 (24.9%) had non- atherosclerotic vasculopathies (NAV); 46 (21.6%) had cardioembolic infarcts (CEI). Hematologically related disorders were diagnosed in 30 (14.1%) patients; the cause of CI could not be established in 25 (11.7%) patients. Fourteen patients (9 men, 5 women, mean age 34.8 years), (6.6%) died within thirty days of their CI: 7 had CEI (7/46, 15.2%); 4 had ACI (4/59, 6.7%); and 3 had NAV (3/53, 5.6%). Our data suggest that young patients with acute CI have a thirty-day ... Concussed youth athletes should be placed on immediate physical and mental rest DURING THE ACUTE PERIOD. That means AVOIDANCE OF physical exercise, computer games, texting, parties, or going to the mall with friends. During the summer, it will mean absence from camp. Because of these factors and the fact that a youth athletes brain is still developing and growing, some experts suggest that youth remain out of CONTACT RISK sports for three weeks or more after they are symptom free, especially if they have a history of prior concussions. The effectiveness of rest in the acute period, and for those with difficult or prolonged recoveries or history of previous concussions, cannot be underestimated.(7,8) How long a period of cognitive and physical rest a student-athlete will need varies. Slowly introducing mild physical activity after the acute period to help athletes stay conditioned, without increasing their symptoms, and should be guided by a licensed health care professional with expertise in ... TY - JOUR. T1 - Determinants of viral clearance and persistence during acute hepatitis C virus infection. AU - Thimme, Robert. AU - Oldach, David. AU - Chang, Kyong Mi. AU - Steiger, Carola. AU - Ray, Stuart C.. AU - Chisari, Francis V.. PY - 2001/11/19. Y1 - 2001/11/19. N2 - The virological and immunological features of hepatitis C virus (HCV) infection were studied weekly for 6 months after accidental needlestick exposure in five health care workers, four of whom developed acute hepatitis that progressed to chronicity while one subject cleared the virus. In all subjects, viremia was first detectable within 1-2 weeks of inoculation, 1 month or more before the appearance of virus-specific T cells. The subject who cleared the virus experienced a prolonged episode of acute hepatitis that coincided with a CD38+ IFN-γ- CD8+ T cell response to HCV and a small reduction in viremia. Subsequently, a strong CD4+ T cell response emerged and the CD8+ T cells became CD38- and started producing IFN-γ in ... TY - JOUR. T1 - Plasma cytokines eotaxin, MIP-1α, MCP-4, and vascular endothelial growth factor in acute lower respiratory tract infection. AU - Relster, Mette Marie. AU - Holm, Anette. AU - Pedersen, Court. N1 - © 2016 APMIS. Published by John Wiley & Sons Ltd.. PY - 2017. Y1 - 2017. N2 - Major overlaps of clinical characteristics and the limitations of conventional diagnostic tests render the initial diagnosis and clinical management of pulmonary disorders difficult. In this pilot study, we analyzed the predictive value of eotaxin, macrophage inflammatory protein 1 alpha (MIP-1α), monocyte chemoattractant protein 4 (MCP-4), and vascular endothelial growth factor (VEGF) in 40 patients hospitalized with acute lower respiratory tract infections (LRTI). The cytokines contribute to the pathogenesis of several inflammatory respiratory diseases, indicating a potential as markers for LRTI. Patients were stratified according to etiology and severity of LRTI, based on baseline C-reactive protein and ... The concentration of fibrin split products (FSP) was measured, by using a modification of the staphylococcal clumping test, in 46 patients who had pulmonary angiography for suspected acute pulmonary embolism and in 12 normal control subjects. The concentration was significantly higher in 19 patients with angiographically documented pulmonary embolism (mean FSP, 158 µg/ml) than in 22 patients without (mean, 8 µg/ml; P , 0.001)-in 18 of the 19 patients the concentration was , 10 µg/ml; in 19 of the 22 patients without pulmonary embolism it was 10 µg/ml or less. The levels were highest in patients with acute symptoms (,3 days) and in those with significant increases in total pulmonary resistance, as measured at cardiac catheterization. Fibrin split products concentration seems to be increased (,10 µg/ml) in most patients with acute pulmonary embolism. We had only one false-negative finding; however, the specificity of an elevation of this variable in acute pulmonary embolism needs further ... Introduction/Hypothesis: We examined the prevalence and outcomes of patients admitted with acute cerebrovascular disease (ACVD) and concomitant acute myocardial infarction (AMI).. Methods: We utilized the Healthcare Cost and Utilization Project Nationwide Inpatient Sample database (1998-2009) and identified 1,760,415 adult ACVD patients among 92,848,710 patients enrolled. Using SAS 6.4 and applying SPSS 22 the outcome variables mortality, length of hospital stay (LOS), hospital costs ,$20,000, and disposition (home or any care facility) were selected and logistic regression analyses was performed adjusting for the covariates hypertension, diabetes mellitus, age, race, sex, number of comorbidities, and care complexity (numbers of inpatient procedures) among all ACVD with and without AMI.. Results: Mean age was 71 years (SD 15) with 76% ,65 years old; 54% female gender; 55% Whites, 11% Blacks, and 6% Hispanics. Among all ACVD, 66% had HTN, 28% DM, AMI 4.1%, LOS was 7.6 days (SD 9.8), in-patient ... TY - JOUR. T1 - CXCL12-Producing Vascular Endothelial Niches Control Acute T Cell Leukemia Maintenance. AU - Pitt, Lauren A.. AU - Tikhonova, Anastasia N.. AU - Hu, Hai. AU - Trimarchi, Thomas. AU - King, Bryan. AU - Gong, Yixiao. AU - Sanchez-Martin, Marta. AU - Tsirigos, Aris. AU - Littman, Dan R.. AU - Ferrando, Adolfo A.. AU - Morrison, Sean J.. AU - Fooksman, David R.. AU - Aifantis, Iannis. AU - Schwab, Susan R.. PY - 2015/6/8. Y1 - 2015/6/8. N2 - The role of the microenvironment in Tcell acute lymphoblastic leukemia (T-ALL), or any acute leukemia, is poorly understood. Here we demonstrate that T-ALL cells are in direct, stable contact with CXCL12-producing bone marrow stroma. Cxcl12 deletion from vascular endothelial, but not perivascular, cells impeded tumor growth, suggesting a vascular niche for T-ALL. Moreover, genetic targeting of Cxcr4 in murine T-ALL after disease onset led to rapid, sustained disease remission, and CXCR4 antagonism suppressed human T-ALL in primary xenografts. ...