Looking for online definition of eccrine acrospiroma in the Medical Dictionary? eccrine acrospiroma explanation free. What is eccrine acrospiroma? Meaning of eccrine acrospiroma medical term. What does eccrine acrospiroma mean?

Acrospiroma: A rare cutaneous tumor of eccrine sweat gland origin. It is most commonly found on the extremities and is usually benign. There is no indication that heredity or external agents cause these tumors.

Hidradenoma (also known as acrospiroma, from akral peripheral + spiroma epithelial tumor of sweat gland) refers to a benign adnexal tumor of the apical sweat gland. Another name for Hidradenoma is Cystadenoma and Hydrocystadenomas. These are 1-3 cm translucent blue cystic nodules.It usually presents as a single, small skin-colored lesion, and is considered distinct from the closely related poroma. Hidradenomas are often sub-classified based on subtle histologic differences, for example:[citation needed] clear-cell hidradenoma or acrospiroma nodular hidradenoma or acrospiroma solid-cystic hidradenoma Discussion of sweat gland tumors can be difficult and confusing due to the complex classification and redundant terminology used to describe the same tumors. For example, acrospiroma and hidradenoma are synonymous, and sometimes the term acrospiroma is used to generally describe benign sweat gland tumors. In addition, a single lesion may contain a mixture of cell-types. There has also been a ...

INTRODUCTION. Eccrine porocarcinoma was first described by Pinkus and Mehregan in 1963.1 It is a rare, malignant neoplasm that originates in the eccrine sweat glands acrosyringium, representing between 0.005 and 0.01% of skin tumors.2 It usually occurs in elderly people and women, with predominance of lower limb lesions, followed by trunk and head.3 It is clinically presented in varied forms and metastases may occur in 20% of cases for regional lymph nodes and in 10% of cases for internal organs.4 A normal computerized tomography indicates a better prognosis.5 Many therapeutic possibilities have been reported, with variable results; it is more common to propose conventional surgical removal or Mohs micrographic surgery. Surgical excision of the primary lesion is curative in 70 to 80% of cases.4 The objective of this report is to present a rare neoplastic lesion of chronic progression and large dimensions, whose diagnosis was delayed by the clinical presentation and whose treatment proved to be ...

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Several years ago, Ian McDonell, a Staff Sergeant with the Ottawa Police and father of three had just lost his father to cancer and his brother was dying of melanoma. Ians wife insisted he see his physician to check out a mole on his back. It turned out to be an ulcerated nodular malignant melanoma - an aggressive form of skin cancer.. Ian had surgery to remove it along with a lymph node from his left groin. Several weeks later, he had a lymph node removed from his armpit. Following these surgeries, he had no signs of cancer, but due to his familys history, Ian was at high risk for relapse.. Sobering news. Ian was feeling well, but during a standard monitoring visit in June 2017, his CT and MRI scans showed sobering news. He had half a dozen tumours in his groin and abdomen, and three more tumours metastasized to his brain. Ians cancer was stage 4.. Given the severity of the findings, Dr. Michel Ong at The Ottawa Hospital suggested an aggressive approach - a recently approved immunotherapy ...

This study shows for the first time that the tandemly repeated icosapeptide of human MUC1 underlies a genetic sequence polymorphism at three positions (underlined): PDTRPAPGSTAPPAHGVTSA. The concerted replacement DT--|ES (sequence variation 1) and the single replacements P--|Q (sequence variation 2), P--|A (sequence variation 3), and P--|T (sequence variation 4) were identified by sequencing of polymerase chain reaction products and studied by minisatellite variant repeat analysis for their incidence and topology in the 5 and 3 peripheral regions of the variable number of tandem repeats domain. Minisatellite variant repeat analyses were performed with 27 individual samples of genomic DNA from human cells and tissues covering 30-60% of the domain. Within the peripheral regions, sequence variations 1-4 occur at high incidence and show a nearly constant repeat topology in all individual normal and tumor samples. Also, individuals who were non-Caucasian or of different ethnic background were found to have

Tidwell WJ, Mayer JE, Malone J, Schadt C, Brown T. Treatment of eccrine porocarcinoma with Mohs micrographic surgery: a cases series and literature review. Int J Dermatol. 2015 Sep;54(9):1078-83. doi: 10.1111/ijd.12997. Epub 2015 Jul 23. Review. PubMed PMID: 26205087 ...

Eccrine poroma originates from eccrine sweat glands of skin. The usual site of its occurrence is palm or sole. Exact cause of this tumor is not known but it is believed to be caused as a result of genetic mutation.

Normal and malignant cells release a variety of different vesicles into their extracellular environment. The most prominent vesicles are the microvesicles (MVs, 100-1 000 nm in diameter), which are shed of the plasma membrane, and the exosomes (70-120 nm in diameter), derivates of the endosomal system. MVs have been associated with intercellular communication processes and transport numerous proteins, lipids and RNAs. As essential component of immune-escape mechanisms tumor-derived MVs suppress immune responses. Additionally, tumor-derived MVs have been found to promote metastasis, tumor-stroma interactions and angiogenesis. Since members of the carcinoembryonic antigen related cell adhesion molecule (CEACAM)-family have been associated with similar processes, we studied the distribution and function of CEACAMs in MV fractions of different human epithelial tumor cells and of human and murine endothelial cells. Here we demonstrate that in association to their cell surface phenotype, MVs released ...

The poroid family of neoplasms includes hidroacanthoma simplex, eccrine poroma, dermal duct tumor, and poroid hidradenoma. These benign adnexal neoplasms are derived from the eccrine or apocrine sweat ducts or glands. Poroid neoplasms, including poro

Poroid neoplasms (PN)在傳統的分類上包含四種良性的汗腺瘤：單純汗腺瘤 (hidracanthoma simplex, HS)、汗腺汗孔瘤 (eccrine poroma, EP)、真皮汗管瘤 (dermal duct tumor, DDT)、汗孔樣汗腺瘤 (poroid hidradenoma, PH)。此些中文譯名容易相互混淆，在本文中將使用英文簡稱或直接以英文代替以利閱讀。 HS 完全局限於表皮內(Fig. 1)，而DDT及PH (Fig. 2)則完全局限於真皮層裡；至於EP(Fig. 3)則介於兩者之間；在一 ..................More ...

Hypoxia is a key regulatory factor in tumour growth, activating angiogenesis, glycolysis and cell migration. It is readily recognized by the intracellular accumulation of hypoxia-inducible factor 1alpha (HIF1alpha) and HIF2alpha. Accumulation of HIF1alpha and HIF2alpha was detected immunohistochemically in a series of 46 nodular malignant melanomas of the skin (epithelioid cell variant), treated with wide local excision. The results were correlated with vascular density (VD) and expression of the angiogenesis-stimulating factors vascular endothelial growth factor (VEGF) and thymidine phosphorylase (TP). Further associations were sought with patient prognosis and the important histopathological features of Breslows thickness, Clarks level of invasion, mitotic rate, inflammatory cell infiltrates and tumour ulceration. HIF1alpha and HIF2alpha accumulation in malignant melanomas was directly correlated with VEGF expression. Tumours with high VEGF or HIF2alpha expression were associated with a poorer

OBJECTIVES: To investigate the expression of luminal (K77), peripheral (K1) and further discriminatory keratins in two eccrine sweat gland tumours: syringoma, thought to show differentiation towards luminal cells of intraepidermal sweat ducts and eccrine poroma, considered to arise from poroid cells, i.e. peripheral duct cells; and keratinocytes of the lower acrosyringium/sweat duct ridge differentiating towards cells of intradermal/intraepidermal duct segments ...

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