TY - JOUR. T1 - Acid Ceramidase Deficiency in Mice Results in a Broad Range of Central Nervous System Abnormalities. AU - Sikora, Jakub. AU - Dworski, Shaalee. AU - Jones, E. Ellen. AU - Kamani, Mustafa A.. AU - Micsenyi, Matthew C.. AU - Sawada, Tomo. AU - Le Faouder, Pauline. AU - Bertrand-Michel, Justine. AU - Dupuy, Aude. AU - Dunn, Christopher K.. AU - Xuan, Ingrid Cong Yang. AU - Casas, Josefina. AU - Fabrias, Gemma. AU - Hampson, David R.. AU - Levade, Thierry. AU - Drake, Richard R.. AU - Medin, Jeffrey A.. AU - Walkley, Steven U.. PY - 2017/4/1. Y1 - 2017/4/1. N2 - Farber disease is a rare autosomal recessive disorder caused by acid ceramidase deficiency that usually presents as early-onset progressive visceral and neurologic disease. To understand the neurologic abnormality, we investigated behavioral, biochemical, and cellular abnormalities in the central nervous system of Asah1P361R/P361R mice, which serve as a model of Farber disease. Behaviorally, the mutant mice had reduced ...
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Sucrose non-fermenting protein (SNF1)-related kinase (SNRK) is a homologue of the yeast Snf1 kinase, mutants of which fail to thrive when provided with non-fermentable carbon sources. In the mouse lung SNRK expression is specific to capillary endothelial cells [63]. SNRK is phosphorylated and activated by the LKB1 serine/threonine-protein kinase that regulates cell polarity and functions also as a tumor suppressor [64]. In view of the vascular abnormalities found in LKB1 null mice LKB1 has been placed in the VEGF signalling pathway [65]. Together, these lines of evidence suggest that SNRK is also in the VEGF signalling pathway.. Monoamine oxidase A (MAOA) degrades amine neurotransmitters including serotonin. MAOA is located on the X chromosome and its upregulation in IPAH suggests a possible involvement in the development IPAH given the female prederiliction of the disease.. Acid ceramidase or N-acylsphingosine amidohydrolase (ASAH1) cleaves ceramide into sphingosine and a free fatty acid. Both ...
Carmofur (INN) or HCFU (1-hexylcarbamoyl-5-fluorouracil) is a pyrimidine analogue used as an antineoplastic agent. It is a derivative of fluorouracil, being a lypophilic-masked analog of 5-FU that can be administered orally. Carmofur prodrug is ingested and taken up in the intestine, overcoming the problem of 5-FU degradation by dihydropyrimidine dehydrogenase. Once inside a cell, carmofur prodrug is converted into 5-FU. The mechanism of action of carmofur prodrug is traditionally thought to be the generation of 5-FU. However, carmofur is a highly potent acid ceramidase (AC) inhibitor. Ceramide influences cancer cell survival, growth and death. Inhibition of AC activity sensitizes tumor cells to the effects of antineoplastic agents and radiation. Product marketing for carmofur started in 1981. Carmofur has also been used as adjuvant chemotherapy for curatively resected colorectal cancer patients in China, Japan, and Finland for many years. Trials and meta-analyses have confirmed that the drug is ...
An authentic small animal model of Farber disease would greatly facilitate research into disease mechanisms and aid in the development of effective therapies. Unfortunately, a complete knock‐out model of Farber disease resulted in early embryonic lethality (Li et al, 2002) and a reduction of ACDase activity in the ovaries of a conditional knock‐out resulted in oocyte apoptosis (Eliyahu et al, 2012). These data highlight the difficulty in generating mouse models of certain LSDs, in particular the lipid storage disorders. These data also suggest that normal ceramide levels and metabolism are critical for early embryonic development.. Significant progress has been made towards effective therapies for LSDs through the use of recombinant enzyme replacement, bone marrow transplantation (BMT), small molecule drugs and gene therapy. It is likely that Farber disease would be responsive to similar approaches. However, the lack of an authentic animal model of Farber disease has hindered this ...
Conclusions A significant percentage of moderate Farber Disease patients are likely diagnosed as having JIA. Given this finding, it is important to increase awareness of Farber Disease in the pediatric rheumatology community. Differential diagnosis can be made by accounting for the comparatively early onset, progressive symmetric arthritis, presence of subcutaneous nodules at the joints, scalp and/or spine, and an unusual, hoarse cry or voice (due to nodule formation on the larynx) in FD patients. Based on experience with bone marrow transplantation in Farber Disease2, enzyme replacement therapy could resolve or significantly attenuate the arthritis phenotype in patients. Such therapy is currently under development. We propose that Farber Disease can account for specific cases diagnosed as JIA, and that clinically guided genetic screening of the JIA population will reveal patients who can benefit from disease-specific care and treatment.. ...
Farber disease (also known as Farbers lipogranulomatosis, ceramidase deficiency, "Fibrocytic dysmucopolysaccharidosis," and "Lipogranulomatosis"[1]:545) is an extremely rare (80 cases reported worldwide to this day[2]) autosomal recessive lysosomal storage disease marked by a deficiency in the enzyme ceramidase that causes an accumulation of fatty material sphingolipids leading to abnormalities in the joints, liver, throat, tissues and central nervous system. Normally, the enzyme ceramidase breaks down fatty material in the bodys cells. In Farber Disease, the gene responsible for making this enzyme is mutated. Hence, the fatty material is never broken down and, instead, accumulates in various parts of the body, leading to the signs and symptoms of this disorder. ...
This invention provides a novel ganglioside ceramidase which has a substrate specificity at least for GD1a, GM1, GM2 and GM3 and acts at least on GD1a, GM1, GM2 and GM3 and catalyzes the reaction of hydrolysis of ganglioside to lysoganglioside and fatty acid.This invention further provides a process for producing the novel ganglioside ceramidase which comprises cultivating ganglioside ceramidase producing strain belonging to the genus Nocardia in a culture medium and collecting ganglioside ceramidase from the culture.
Introduction. In this study, we evaluated the anticancer activity of DM102 [(2R,3Z)-N-(1-hydroxyoctadec-3-en-2-yl)pivalamide], a novel inhibitor of the enzyme acid ceramidase (AC), a key regulator of ceramide metabolism, in combination with C6-ceramide (C6-cer) in human breast cancer cells. Ceramide, a bioactive sphingolipid and potent enhancer of apoptosis, is known to play a role in chemo- and radiation-induced cell death. AC tempers ceramide-induced apoptosis by hydrolysis, producing sphingosine and free fatty acid, thus reducing intracellular ceramide levels and providing substrate for sphingosine kinase, which converts sphingosine to sphingosine 1-phosphate. AC has emerged as a putative anticancer target following reports of upregulation in prostate cancer and in some breast tumors. In the present work, we determined whether the introduction of an AC inhibitor would enhance the apoptosis-inducing effects of C6-cer in breast cancer cells.. Methods. Cultured breast cancer cells were ...
Sidney Farber (September 30, 1903 - March 30, 1973) was an American pediatric pathologist. He is regarded as the father of modern chemotherapy, and the Dana-Farber Cancer Institute is named after him. He was born in Buffalo, New York to Jewish parents Simon and Matilda (Goldstein) Farber. He was the third oldest of 14 siblings. He was the younger brother of the noted philosopher and University of Buffalo professor Marvin Farber (1901-1980). Sidney Farber graduated from SUNY Buffalo in 1923. In the mid-1920s, Jewish students were often refused admission to US medical schools, prompting him to go to Europe. As Farber was fluent in German, he undertook his first year of medical school at the Universities of Heidelberg and Freiburg in Germany. Having excelled in Germany, Farber entered Harvard Medical School as a second-year student and graduated in 1927. After graduate training in pathology at Peter Bent Brigham Hospital (the predecessor of Brigham and Womens Hospital) in Boston, Massachusetts, ...
Teijaro, J.R., Turner, D., Nam, Q., Wherry, E.J., LeFrançois, L. and Farber, D.L. (2011) Cutting Edge: Tissue-retentive lung memory CD4 T cells mediate optimal protective responses to influenza. J. Immunol. 187:5510-14.. Sathaliyawala, T., Kubota, M., Yudanin, N., Turner, D., Camp, P., Thome, J.C., Bickham, K.L., Lerner, H., Goldstein, M., Sykes, M., Kato, T and Farber, D.L. (2013) Distribution and compartmentalization of human circulating and tissue-resident memory T cells. Immunity. 38: 187-197. (Also see preview article in same issue by Neuenhahn and Busch, D.H., "Whole body anatomy of human T cells". Immunity. 38:10-12.). Turner, D.L., Bickham, K.L., Farber, D.L. and Lefrancois, L. (2013) Splenic priming of virus-specific CD8 T cells following influenza infection. J. Virol. 87:4496-506. Turner, D.L., Bickham, K.L., Thome, J.J.T., Kim, C., DOvidio, F., Wherry, E.J. and Farber, D.L. (2014) Lung resident niches for the generation and maintenance of influenza-specific memory T cells. Mucosal ...
The KRAB-zinc finger proteins (KRAB-ZFPs) represent an extremely large, but poorly understood, family of transcriptional regulators in mammals. (Sera) cells, endogenous KRAB-ZFPs do not. Rather, KRAB-ZFPs and KAP1 relocalise to novel nucleoplasmic foci that we possess termed KRAB- and KAP1-connected (KAKA) foci. HP1s can also concentrate in these foci and there is a close spatial […]. ...
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Overview (in German). Der Sphingolipidmetabolismus kann virale Infektionen und Immunantworten auf vielen Ebenen beeinflussen. In unserem Masernvirus (MV)-Infektionsmodell des zentralen Nervensystems (ZNS) beobachteten wir bereits die Folgen der sauren Sphingomyelinase (Asm)-Defizienz in Mäusen, nämlich eine verminderte Widerstandsfähigkeit gegenüber viraler Infektion, und entdeckten, dass sowohl genetische Defizienz, als auch pharmakologische Hemmung der Asm die Aktivität CD4+ Foxp3+ regulatorischer T-Zellen (Treg) erhöht (Hollmann et al., J. Immunol, 2016, 197:3130-3141). Nun wollen wir herausfinden, wie assoziierte Reaktionswege und Enzyme, für die teilweise Inhibitoren schon in klinischem Gebrauch sind, genutzt werden können, um den gegenteiligen Effekt zu erreichen, d.h. die antivirale Immunreaktion zu stärken. Vorläufige Daten weisen darauf hin, dass die MV-Infektion durch Inhibition der sauren Ceramidase (Acd) oder der Sphingosin-Kinase-1 gehemmt wird. In der kommenden ...
Im a default crier. I happy-cry, stress-cry, romantic-comedy-cry, regular-comedy-cry and, apparently, I even doctor-in-training-cry. Crying is a tough response, especially for someone who wants to take care of sick patients. My default reaction poses challenges for my future career. I had my first taste of this when a patient actor brought me to tears. An actor? Thats ridiculous, you might think. It was all pretend and yet, I broke down. Im ...
Team ZipCar, a group of cyclers put together for Dana Farber Cancer Institutes annual Pan Mass Challenge, a grueling bike-a-thon raising money for cancer research and treatment.
Farber Specialty Vehicles has been awarded U.S. Communities contract for Specialty Vehicles, Equipment and Accessories and any Related Equipment, Supplies and Services.
K00654 SPT; serine palmitoyltransferase [EC:2.3.1.50] K00654 SPT; serine palmitoyltransferase [EC:2.3.1.50] K00654 SPT; serine palmitoyltransferase [EC:2.3.1.50] K04708 E1.1.1.102; 3-dehydrosphinganine reductase [EC:1.1.1.102] K04710 CERS; ceramide synthetase [EC:2.3.1.24] K04710 CERS; ceramide synthetase [EC:2.3.1.24] K04710 CERS; ceramide synthetase [EC:2.3.1.24] K04710 CERS; ceramide synthetase [EC:2.3.1.24] K04710 CERS; ceramide synthetase [EC:2.3.1.24] K04710 CERS; ceramide synthetase [EC:2.3.1.24] K12348 ASAH1; acid ceramidase [EC:3.5.1.23] K12349 ASAH2; neutral ceramidase [EC:3.5.1.23] K01441 ACER1_2; alkaline ceramidase [EC:3.5.1.23] K01441 ACER1_2; alkaline ceramidase [EC:3.5.1.23] K04711 ACER3; dihydroceramidase [EC:3.5.1.-] K04712 DEGS; sphingolipid 4-desaturase/C4-monooxygenase [EC:1.14.19.17 1.14.18.5] K04712 DEGS; sphingolipid 4-desaturase/C4-monooxygenase [EC:1.14.19.17 1.14.18.5] K04714 SGMS; shingomyelin synthase [EC:2.7.8.27] K04714 SGMS; shingomyelin synthase [EC:2.7.8.27] ...
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In June 3, 1948, The New England Journal of Medicine published a study by Sidney Farber, MD, showing that a synthetic compound, 4-aminopteroylglutamic acid (aminopterin), could induce remissions in seriously ill children with acute leukemia.1 Although the study was small-just 16 children-10 showed clinical, hematologic, and pathologic evidence of improvement. Even though the childrens remissions were short-lived, Dr. Farbers findings were so groundbreaking-until then, no drug had proved effective against non-solid tumor cancers-they ushered in the era of chemotherapeutics, chemical agents that could stop cancer cells from growing and replicating, in effect killing them.. Aminopterin was later replaced by methotrexate, a similar but more effective folic acid antagonist with fewer side effects, which is still used today in the treatment of leukemia and other blood and solid tumor cancers. Nevertheless, the results of Dr. Farbers study earned him the title, the Father of Modern ...
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Temporary restorations often look almost as good as the final restoration. We want the patients to look at the temporary and say, "Wow! This looks great and feels great." The final restoration will be better. but we need to work this all out in the temporary stage. Because temporary restorations look so good, patients sometimes delay getting a final crown or final bridge on their implants. The problem with that scenario is that bacteria can leak under the temporary restoration and that may affect the health of the implant in the long run. There is a set amount of time that a temporary restoration is designed to last, and people should not go beyond that timeframe. Typically six months is the longest amount of time that I would recommend that a patient keep a temporary restoration. They need to return to the office in a timely manner and get their new, permanent teeth.. Dr. Alan H. Farber. Periodontist. Offices in Hauppauge and Medford, NY. New Patients Welcome. www.longislandperio.com. ...
When you need extruded film and sheet, Farber Plastics Inc.is the supplier of choice. The Farber family has been extruding thermoplastic film and sheet since 1963, producing HIPS film and sheet since 1975. With a multi-million dollar expansion into PET (polyethylene terephthalate) roll stock in 2007, the company, with Lewis Farber as president, continues to grow and serve a variety of markets ...
The DF/HCC Connect:Science seminar series plans to involve speakers who are leaders in cancer biology, immune oncology and other fields from across the...
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This data article provides gene expression profiles, determined by using real-time PCR, of fibroblasts and keratinocytes treated with 0.01% and 0.001% extracts of neem plant (Azadirachta indica), local name "Kohomba" in Sri Lanka, harvested in Sri Lanka. For fibroblasts, the dataset includes expression profiles for genes encoding hyaluronan synthase 1 (HAS1), hyaluronan synthase 2 (HAS2), hyaluronidase-1 (HYAL1), hyaluronidase-2 (HYAL2), versican, aggrecan, CD44, collagen, type I, alpha 1 (COL1A1), collagen, type III, alpha 1 (COL3A1), collagen, type VII, alpha 1 (COL7A1), matrix metalloproteinase 1 (MMP1), acid ceramidase, basic fibroblast growth factor (bFGF), fibroblast growth factor-7 (FGF7), vascular endothelial growth factor (VEGF), interleukin-1 alpha (IL-1α), cyclooxygenase-2 (cox2), transforming growth factor beta (TGF-β), and aquaporin 3 (AQP3 ...
When David Hahns daughter was in high school, she had to complete an oral-history project on someone with an extraordinary life story.. For Hahn, one person immediately came to mind: Erich Farber.. "He has a story that you really wont find from anyone else," said Hahn, chair of the Department of Mechanical and Aerospace Engineering at the University of Florida. "He was truly remarkable.". Farber, who became a faculty member in the department in 1954 and eventually served as director of UFs Solar Energy and Energy Conversion Laboratory, passed away on April 9. He was 95.. He was a world-renowned expert, cutting-edge researcher and 36-year professor in solar-energy technologies. In addition, he earned military decorations in World War II and served as a mountain-climbing instructor and Boy Scout leader.. "My dad had the ability to do just about anything," said his son, Webb Farber, "and he did.". Erich Farber was passionate about researching and developing solar-energy technologies at a time ...
... is a very competent attorney who has been practicing law for 40 years. Mr. Farber is a Personal Injury lawyer specializing primarily in Motor Vehicle Accidents. He is licensed to practice in the state of Pennsylvania, the U.S. District Court, the Eastern District of Pennsylvania, and the Middle District of Pennsylvania.. Stephen graduated from Penn State University with a BA in Mathematics, and spent a year teaching Junior High School Math to save money for Law School. He earned his Juris Doctor from Temple University School of Law. While in Law School, Stephen had the rare opportunity to prosecute cases, as part of his coursework, when he attended a Prosecution Seminar taught by then District Attorney, Arlen Specter.. Mr. Farber joined Master Weinstein Moyer, P.C. in 1994, after spending several years at two prominent Philadelphia area law firms and seven years as a Partner in his own firm. In his earliest years as an attorney, Mr. Farber practiced Criminal Law in addition to ...
The epidermis is the outermost layer of skin that acts as a barrier to protect the body from the external environment and to control water and heat loss. This barrier function is established through the multistage differentiation of keratinocytes and the presence of bioactive sphingolipids such as c …
A Board Certified physician in Radiation Oncology, Dr. Leonard Farber has been in private practice for over a decade, recently serving as Chairman of Radiation Oncology at Staten Island University Hospital. Dr. Farber specializes in adult radiation oncology, with particular focus on breast cancer, prostate cancer and gastrointestinal malignancies, lymphomas, head and neck cancers and lung cancers. He is an expert in HDR brachytherapy for various types of cancers, including breast, skin and gynecologic malignancies, and intracranial and body radiosurgery.. After receiving his B.S. and B.A. at the State University of New York at Binghamton, Dr. Farber pursued his M.D. at the Mt. Sinai School of Medicine in New York. Following an internship in internal medicine at Beth Israel Medical Center in New York, he did his residency in Radiation Oncology at the Hospital of the University of Pennsylvania in Philadelphia, where he served as Chief Resident. Dr. Farber is a member of the American Society for ...
Volunteer Name: Adam Farber Project Location: Bulenga, Uganda Program Dates: July 2013 (2 weeks) Volunteered At: Orphanage and school What was your favorite memory of this trip? The kids. Theyre so great and so excited to have a guest teacher. Getting to know them over time and watching them learn was a great experience.  What was the most difficult thing you experienced? Figuring out how cautious to be with safety at night. As time went on it seemed fine to be out for a couple hours after dark if walking with a group, especially if with a local. For a later night in Kampala it was also easy to arrange a private driver for a reasonable fee. What was the one thing you wished you were better prepared for? Understanding what to worry about safety-wise. The quick answer is dont worry in Bulenga unless its been dark for a while and all the people have gone home. Of course there is no need to take unnecessary risks either, such as walking alone anytime at night or carrying lots of money or
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my husband was in Mercks PD-1 inhibitor ( keytruda) between Jan 2015 and June 2015. He was on the highest dose of 10mg/kg every 2 weeks. At the time, there was no clinical trial that would guarantee he gets a PD-1 inhibitor . There was only one that randomized between avastin or Opdivo blindly and we didnt want to get avastin at the time. Hence, we went with the keytruda study grouping solid tumors together at the highest dose. He never had a swelling. What happened was 2 month after enrolling, he started having subtle enhancements that the NO was not sure whether they are inflammation or recurrence. Things stayed this way with increased enhancements till in June we decided this cant be enhancement and he sat for a craniotomy that confirmed our doubts that this was definetly recurrence with minimal swelling or inflammation. The pathology was confirmed by Both Dana Farber and Johns Hopkins ...
Blogger Euan Semple recently highlighted a key point about Enterprise 2.0 adoption that ZDNets own Dan Farber also found worthy of note over the weekend. And that is that Enterprise 2.0 will happen in your organization entirely by itself, whether you encourage it, discourage it, or even consign it to benign neglect. Euan actually laid out three strategies in semi-tongue cheek form likely meant as a shot across the bow of complacent IT departments; whether you get out of the way, actively encourage it, or do absolutely nothing, Enterprise 2.0 platforms like blogs, wikis, and related social, emergent, freeform Web 2.0-style apps are coming to your company, and in fact are almost certainly there already.
Brownstein Hyatt Farber Schreck is a unique law firm. Walk into any of our offices and youll immediately recognize a different type of energy. Complacency doesnt have a place here. Flexibility and... ...
Im here at an AttentionTrust luncheon, featuring a talk by Michael Goldhaber and some AttentionTrust and GestureBank related announcements. Dan Farber is here as well, so check his blog for related coverage (and his photos are included below).
Petang semalam, mak sedara dia datang umah minta tunjukkan jalan ke Klinik Gigi di Seri Gombak.. so petang tu bawa la si Naufal jalan-jalan sekali.. so untuk asah skill mengambil gambar yang dah tumpul nie, ataicha bawa la kamera.. iya nak asah skill kena laa banyak ambik gambar.. baru dapat skill dalam mencari angle kan... tapi untuk awal-awal ni setting auto je ...
There is less radioactive Cs in wood near Vermont Yankee than in wood from a hundred miles away. Guest post by Stewart Farber, MSPH, explains why.
HEADER HYDROLASE 23-OCT-09 3KE0 TITLE CRYSTAL STRUCTURE OF N370S GLUCOCEREBROSIDASE AT ACIDIC PH. COMPND MOL_ID: 1; COMPND 2 MOLECULE: GLUCOSYLCERAMIDASE; COMPND 3 CHAIN: A, B; COMPND 4 SYNONYM: BETA-GLUCOCEREBROSIDASE, ACID BETA-GLUCOSIDASE, D-GLUCOSYL- COMPND 5 N-ACYLSPHINGOSINE GLUCOHYDROLASE, ALGLUCERASE, IMIGLUCERASE; COMPND 6 EC: 3.2.1.45; COMPND 7 ENGINEERED: YES; COMPND 8 MUTATION: YES SOURCE MOL_ID: 1; SOURCE 2 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 3 ORGANISM_COMMON: HUMAN; SOURCE 4 ORGANISM_TAXID: 9606; SOURCE 5 GENE: GBA, GC, GLUC; SOURCE 6 EXPRESSION_SYSTEM: SPODOPTERA FRUGIPERDA; SOURCE 7 EXPRESSION_SYSTEM_TAXID: 7108 KEYWDS TIM BARREL, ALTERNATIVE INITIATION, DISEASE MUTATION, DISULFIDE BOND, KEYWDS 2 GAUCHER DISEASE, GLYCOPROTEIN, GLYCOSIDASE, HYDROLASE, ICHTHYOSIS, KEYWDS 3 LIPID METABOLISM, LYSOSOME, MEMBRANE, SPHINGOLIPID METABOLISM EXPDTA X-RAY DIFFRACTION AUTHOR R.R.WEI,S.BOUCHER,C.Q.PAN,T.EDMUNDS REVDAT 1 27-OCT-10 3KE0 0 JRNL AUTH ...
The adiponectin receptor 1 for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism (Tanabe et al. 2015; Yamauchi et al. 2003. Required for normal glucose and fat homeostasis and for maintaining a normal body weight. ADIPOQ-binding activates a signaling cascade that leads to increased AMPK activity, and ultimately to increased fatty acid oxidation, increased glucose uptake and decreased gluconeogenesis. Has high affinity for globular adiponectin and low affinity for full-length adiponectin. The 3-d structure revealed ceramidase activity for both ADIPOR1 and ADIPOR2; however, the two structures are substantially different (Vasiliauskaité-Brooks et al. 2017 ...
The adiponectin receptor 1 for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism (Tanabe et al. 2015; Yamauchi et al. 2003. Required for normal glucose and fat homeostasis and for maintaining a normal body weight. ADIPOQ-binding activates a signaling cascade that leads to increased AMPK activity, and ultimately to increased fatty acid oxidation, increased glucose uptake and decreased gluconeogenesis. Has high affinity for globular adiponectin and low affinity for full-length adiponectin. The 3-d structure revealed ceramidase activity for both ADIPOR1 and ADIPOR2; however, the two structures are substantially different (Vasiliauskaité-Brooks et al. 2017). It may function with adiponectin to stimulate cholesterol efflux via ABCA1 (Hafiane et al. 2019 ...
A trip to the past and to the future - all in one night.. This festive season, Johns Hopkins University researchers dug deep into their reserves of scientific expertise to explain how these inexplicable plot lines in holiday classics like Rudolph the Red Nosed Reindeer, How the Grinch Stole Christmas, and A Christmas Carol just might be (almost) (possibly) possible:. A biologist explains Rudolphs nose:. Steve Farber, principal investigator at the Carnegie Institution for Science and a Johns Hopkins biology professor. VIDEO: https://www.youtube.com/watch?v=Eb6Ni2BIsn8&feature=youtu.be. Although reindeer noses arent typically red, or infused with enough light to guide a sleighs airspace, Farber says other earthly creatures are that color and glow through bioluminescence or fluorescence - everything from jelly fish to sea anemones to the zebrafish he studies. If genetic material from one of those organisms found a way into Rudolphs DNA, Farber supposes he, too, could glow red - or at least a ...
Hi everyone,. I have been on and off this site.. My husband was diagnosed with GBM in March 2012. We have had our fair amount of ups and downs, MRIs showing improvement and then spread. We live in Massachusetts and I brought my husband to Brigham and Womens, as well as Dana Farber - having seen one of the most knowledgeable doctors in the Boston area, who is from Duke University. There has been some forgetfulness, etc. There has been some increasing forgetfulness, but its funny how the brain is able to find new paths. We lost my father-in-law unexpectedly 2 days after Christmas. We had been on Temodar as most GBM patients start with. Initially, it was helping and there was shrinkage. My husband has 3 tumors, all inoperable. Our last trip to Dana Farber, he was hospitalized at BWH and had an MRI around 9/25/2012, which showed spread to the brain stem, left side of brain (original tumors on right), "fingers", and some suspicious cells in his CSF - this was a shock to us because he had been doing ...
A 45 year old Black female without significant past medical history was admitted with insidious cough, dyspnea, nausea, vomiting, and progressive weight loss. She suddenly went into respiratory distress and succumbed to death. Autopsy subsequently showed widespread granulomatous disease. This slide of one of the lung lesions shows a noncaseating granulocyte with a fibrotic center surrounded by palisading histiocytes, consistent with a diagnosis of nodular sarcoma.
SAE SP.; International spring fuels and lubricants meeting; Statistics, measurement & testing; Toulouse, France, 2004; Jun, 2004, 1-6 -- Warrendale, Penn.; [Great Britain]; Society of Automotive Engineers; c2004 (pages 1-6) -- ...