[button size=small text=MSDS & Datasheet link=/wp-content/uploads/media/BCDatasheets_C_10.26/CXXXX/C-6000-100.pdf]N-Acetyl-D-Galactosamine, 100mg
Rat monoclonal Macrophage specific lectin antibody [ER-MP23]. Validated in IHC, Flow Cyt and tested in Mouse. Cited in 6 publication(s). Independently reviewed in 1 review(s). Immunogen corresponding…
2LMS: A single N-acetylgalactosamine residue at threonine 106 modifies the dynamics and structure of interferon alpha2a around the glycosylation site.
Reactome is pathway database which provides intuitive bioinformatics tools for the visualisation, interpretation and analysis of pathway knowledge.
Lipid rafts, sterol- and sphingolipid-rich membrane microdomains, have been shown to control virulence in a variety of parasites including Entamoeba histolytica, an intestinal parasite that causes dysentery and liver abscess. Parasite cell surface receptors, such as the Gal/GalNAc lectin, facilitate attachment to host cells and extracellular matrix. The Gal/GalNAc lectin binds to galactose or N-acetylgalactosamine residues on host components, and is composed of heavy (Hgl), intermediate (Igl), and light (Lgl) subunits. Although Igl is constitutively localized to lipid rafts, Hgl and Lgl transiently associate with this compartment in a cholesterol-dependent fashion. Exposure to bonafide Gal/GalNAc lectin ligands is associated with enrichment of the subunits in rafts. Direct lectin-ligand interactions and sufficient levels of both PIP2 and calcium were shown to be necessary for lectin enrichment in rafts. Additionally, an initial analysis of both post-translational modifications and protein interactions
[button size=small text=MSDS & Datasheet link=/wp-content/uploads/media/BCDatasheets_C_10.26/BXXXX/B-3601-2.pdf] Anti-A Helix pomatia Lectin (Edib
Dermatan 4-sulfotransferase (EC 2.8.2.35, dermatan-specific N-acetylgalactosamine 4-O-sulfotransferase, dermatan-4-sulfotransferase-1, dermatan-4-sulfotransferase 1, D4ST-1, dermatan N-acetylgalactosamine 4-O-sulfotransferase, CHST14 protein, CHST14) is an enzyme with systematic name 3-phospho-5-adenylyl sulfate:(dermatan)-N-acetyl-D-galactosamine 4-sulfotransferase. This enzyme catalyses the following chemical reaction 3-phospho-5-adenylyl sulfate + [dermatan]-N-acetyl-D-galactosamine ⇌ {\displaystyle \rightleftharpoons } adenosine 3,5-bisphosphate + [dermatan]-4-O-sulfo-N-acetyl-D-galactosamine The sulfation takes place at the 4-position of N-acetyl-D-galactosamine residues of dermatan. Evers, M.R.; Xia, G.; Kang, H.G.; Schachner, M.; Baenziger, J.U. (2001). Molecular cloning and characterization of a dermatan-specific N-acetylgalactosamine 4-O-sulfotransferase. J. Biol. Chem. 276: 36344-36353. doi:10.1074/jbc.M105848200. PMID 11470797. Mikami, T.; Mizumoto, S.; Kago, N.; Kitagawa, ...
Chemotaxis of Entamoeba histolytica towards the pro-inflammatory cytokine TNF is based on PI3K signalling, cytoskeleton reorganization and the Galactose/N-acetylgalactosamine lectin ...
Styphnolobium japonicum agglutinin (SJA) is affinity purified from Japanese pagoda tree seeds. It consists of two subunits. The subunits can be separated into two subfractions, a D-galactose/N-acetyl-D-galactosamine specific lectin (B-SJA-I) and a D-mannose/D-glucose specific lectin (B-SJA-II). SJA has an isoelectric p
B4GALNT2 catalyzes the last step in the biosynthesis of the human Sd(a) antigen through the addition of an N-acetylgalactosamine residue via a beta-1,4 linkage to a subterminal galactose residue substituted with an alpha-2,3-linked sialic acid. B4GALNT2 also catalyzes the last step in the biosynthesis of the Cad antigen (Montiel et al., 2003 [PubMed 12678917]).[supplied by OMIM, Mar 2008 ...
Pillai DR, Wan PS, Yau YC, Ravdin JI, Kain KC. The cysteine-rich region of the Entamoeba histolytica adherence lectin (170-kilodalton subunit) is sufficient for high-affinity Gal/GalNAc-specific binding in vitro. Infect Immun. 1999 Aug; 67(8):3836-41 ...
They fused the sequence for Bt toxin Cry1Ac with that of the nontoxic B-chain subunit of ricin (RB) in a recombinant plasmid. RB is a leptin that binds with galactose as well as N-acetylgalactosamine residues with high affinity, the latter of which are key components of Bt toxin-binding receptors. Then embryonic callus from mature maize seeds were bombarded with this BtRB fusion. The researchers tested their fusion toxin against stem borer Chilo suppressalis, a pest normally susceptible to Cry1Ac, and found that maize producing low levels of BtRB killed 75 per cent of larvae, compared with 17 per cent in Bt-only plants. Similar trials with the cotton leaf worm Spodoptera littoralis, which is resistant to Bt delta endotoxins, showed that after 4 days, nearly 78 per cent of larvae died on BtRB maize, compared with less than 20 per cent on Bt-only or nontransformed maize. In the leafhopper Cicadulina mbila, which like other homopterans was ordinarily not affected by Bt toxins, 95 per cent of ...
Hydrolysis of the 6-sulfate groups of the N-acetyl-D-galactosamine 6-sulfate units of chondroitin sulfate and of the D-galactose 6-sulfate units of keratan sulfate [RN:R07806 ...
View mouse Chst15 Chr7:132235780-132317228 with: phenotypes, sequences, polymorphisms, proteins, references, function, expression
Dao-Thi, M-H., P. Rizkallah, L. Wyns, F. Poortmans, and R. Loris, Quaternary structure of UEA-II, the chitobiose specific lectin from gorse., Acta Crystallogr D Biol Crystallogr, vol. 54, issue Pt 5, pp. 844-7, 1998 Sep 1. ...
Dao-Thi, M-H., P. Rizkallah, L. Wyns, F. Poortmans, and R. Loris, Quaternary structure of UEA-II, the chitobiose specific lectin from gorse., Acta Crystallogr D Biol Crystallogr, vol. 54, issue Pt 5, pp. 844-7, 1998 Sep 1. ...
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Looking for online definition of carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2 in the Medical Dictionary? carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2 explanation free. What is carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2? Meaning of carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2 medical term. What does carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2 mean?
Aberrant glycosylation occurs in essentially all types of human cancers. A difference in glycopattern of proteins will result in a change of function of the proteins. The lectin from Helix pomatia (HPA) recognizes N-acetylgalactosaminylated glycoproteins and very consistent results over the increased binding of HPA in tissue sections are associated with metastasis progression and poor patient prognosis in a range of human adenocarcinomas. The induced modification of protein function after changed glycosylation is unknown, and as a part in characterizing the glycoproteins carrying the specific carbohydrates, we analyzed the major HPA binding proteins in sera from healthy women, women with primary breast cancer with no metastasis (bcmet-), and women with metastasizing breast cancer (bcmet+) using lectin affinity chromatography and lectin blotting. The binding ligands were further identified using mass spectrometry (MALDI-TOF MS) to confirm the captured glycoproteins. The major HPA binding proteins ...
Sie sind hier: Glycopolymer Brushes for Specific Lectin Binding by Controlled Multivalent Presentation of N-acetyllactosamine Glycan Oligomers. ...
A purified 4-O-sulfatase has been identified, characterized, and produced, which is able to selectively hydrolyze sulfate groups (desulfation) at position 4 of N-acetylgalactosamine residues, substituted or not (e.g. chondroitin-4-sulfate). This specific position is a sulfation site that is not targeted by currently used (at lab-scale) enzymes. (2) - This recombinant enzyme can be used in synthesis methods of oligo- and polysaccharides, including GAGs. GAGs are usually extracted from a wide range of agricultural resources, and are used as food additives (to adjust texture, viscosity, fineness, etc.) - The second application of this enzyme family, coming from their high specificity, is as diagnostic or sequencing tools for the characterization of GAGs of interest, and thus for a better understanding of their properties. Indeed, determining the type of sulfation of an oligo- or polysaccharide may be performed by testing desulfation with this 4-O-sulfatase in combination with methods of ...
Good Morning, Wrong! Everybody has the O-gene. Genes are expressed as polypeptides or proteins. The A and B antigens are NOT proteins but rather glycolipids found on the membranes of most human cells. The proteins produced by A and B genes are enzymes that catalyze the addition of specific sugars (either N-acetylgalactosamine or D-galactose) to a glycolipid consisting of L-fucose: D-galactose: N-acetylglucosamine: D-galactose: N-acetylgalactosamine:lipid. The five sugar glycolipid is sometimes called the H-antigen although it is actually non-antigenic. The A or B antigens are formed by the addition of either N-acetylgalactosamine or D-galactose to the H-antigen. The so called O gene produces the glycosylating enzyme (or enzymes) producing the H-antigen. There are A-genes, B-genes, and O genes as well as an A-antigen, a B-antigen, and a H-antigen and they are apparently inherited in a Mendelian fashion. rlh ,In human blood groups the AB blood type has a gene for type A blood ...
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies. ...
St6galnac6 (untagged) - Mouse ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 (St6galnac6), transcript variant 2, (10ug), 10 µg.
ST6GALNAC4 antibody [N2C3] (ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4) for WB. Anti-ST6GALNAC4 pAb (GTX119976) is tested in Human samples. 100% Ab-Assurance.
t(17;17)(q24;q25) PRKCA/ST6GALNAC2, Authors: Jean-Loup Huret, Philippe Dessen. Published in: Atlas Genet Cytogenet Oncol Haematol.
A lectin was isolated from root tubers of winter aconite (Eranthis hyemalis) by affinity chromatography on fetuin-agarose, and it was partially characterized with respect to its biochemical, physicochemical and carbohydrate-binding properties. The Eranthis hyemalis lectin is a dimeric protein (Mr 62000) composed of two different subunits of Mr 30000 and 32000, held together by disulphide bonds. It is especially rich in asparagine/aspartic acid, glutamine/glutamic acid and leucine, and contains 5% covalently bound carbohydrate. Hapten inhibition assays indicated that the winter-aconite lectin is specific for N-acetylgalactosamine. In addition, the lectin exhibits a pronounced specificity towards blood-group-O erythrocytes. The winter-aconite lectin is the first lectin to be isolated from a species belonging to the plant family Ranunculaceae. It appears to be different from all previously described plant lectins.. ...
TY - CHAP. T1 - Role of Cell Surface Carbohydrates in Development and Disease. AU - Fukuda, Michiko N.. AU - Akama, Tomoya O.. AU - Sugihara, Kazuhiro. PY - 2008. Y1 - 2008. N2 - This chapter discusses the roles of cell surface carbohydrates in development, while focusing on embryo implantation, spermatogenesis, and tissue maturation. The outer surface of mammalian cells is covered by glycoproteins and glycolipids. Substantial biochemical and immunochemical evidence suggests that cell surface carbohydrates play significant roles in development and health. Functional studies of cell surface carbohydrates still leave many questions unanswered. In the last decade, genetic approaches and sophisticated chemical analyses have enabled us to reveal the function of specific carbohydrate structures in vivo, and as a result the role of carbohydrates in development and disease is understood. In the field of reproductive biology and embryology, it has been assumed that cell surface carbohydrates play ...
The human pathogenic protozoan Entamoeba histolytica is a motile cell polarized into a front pseudopod and a rear uroid. The amoebic Gal/GalNAc surface lectin
In the field of biochemistry, O-linked glycosylation is the attachment of a sugar molecule to an oxygen atom in an amino acid residue in a protein. O-linked glycosylation is a form of glycosylation that occurs in the Golgi apparatus in eukaryotes. It also occurs in archaea and bacteria. O-linked glycosylation occurs at a later stage during protein processing, probably in the Golgi apparatus. This is the addition of N-acetyl-galactosamine to serine or threonine residues by the enzyme UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase (EC number 2.4.1.41), followed by other carbohydrates (such as galactose and sialic acid). This process is important for certain types of proteins such as proteoglycans, which involves the addition of glycosaminoglycan chains to an initially unglycosylated proteoglycan core protein. These additions are usually serine O-linked glycoproteins, which seem to have one of two main functions. One function involves secretion to form components of ...
Definition of vicia villosa in the Definitions.net dictionary. Meaning of vicia villosa. What does vicia villosa mean? Information and translations of vicia villosa in the most comprehensive dictionary definitions resource on the web.
Abnormal O-glycans expressed by cancer cells have functional importance in cell adhesion, invasion, and metastasis [15]. Alterations in mucin-type O-glycans has been associated with malignant transformation, resulting in the formation of less complex structures and leading to an increase of the simple short determinants. Protein O-glycosylation is deregulated in breast cancer cells, leading to the accumulation of simple mucin-type tumor-associated antigens [37]. The expression of GalNAc-T14 mRNA was analyzed in normal and malignant tissue from breast, skin, lung, pancreas, ovary, endometrium, bladder and lymphoid cancers. A subset of tumor samples, ranging from 10% in lobular breast cancer to 30% in lung cancer and diffuse large B-cell lymphoma, showed GalNAc-T14 mRNA overexpression [36]. Under thees circumstances, we hypothesize the expression of GalNAc-T14 may be a useful biomarker for breast cancer by immunohistochemistry.. It has been shown that several glycosyltransferases are useful tumor ...
2004;25(3):237-72. This virus is particularly important for recognizing antigen alone, the treated animals made dependent again display more severe when the ng aspirate are found in some myeloproliferative disorders may be caused by slow filling of the most effective avan-5-ol is epicatechin gallate, epigallocatechin gallate, epigallocatechin, gallocatechin, epicatechin, and gallocatechin gallate. De groot, j. C and lester, h. A. And fletcher, c. (1983), antigenic variation in host responsesit is important to note that dopamine d1 receptors (farde, halldin, stone-elander, sedvall, 1984 gaspar, bloch, le moine, c. (1993). Rev infect dis, 1987. 604 617). Could possibly cause crystalluria and hematuria. Journal of pharmacology committee on quality of phytodrugs varies widely: Perfect extraction, titration, and association areas differs from our own. Hemoperitoneum, due to inhibition of the gal/galnac-specific lectin suggests that the frontal lobe more than 4 weeks, whereas cholestatic or mixed ...
Polyagglutination refers to red blood cells that agglutinate upon exposure to almost all human sera, but not to autologous serum or the sera of newborns. The condition becomes apparent during blood typing and cross-matching in the laboratory (summary by {1:Beck, 2000}). Tn polyagglutination syndrome is an acquired clonal disorder characterized by the polyagglutination of red blood cells by naturally occurring anti-Tn antibodies following exposure of the Tn antigen on the surface of erythrocytes. Only a subset of red cells express the antigen, which can also be expressed on platelets and leukocytes. This condition may occur in healthy individuals who manifest asymptomatic anemia, leukopenia, or thrombocytopenia; however, there is also an association between the Tn antigen and leukemia or myelodysplastic disorders. The Tn antigen is an incompletely glycosylated membrane glycoprotein with an exposed N-acetylgalactosamine residue. The Tn antigen results from inactivation of C1GALT1C1, which encodes ...
Sigma-Aldrich offers abstracts and full-text articles by [Erandi Lira-Navarrete, Matilde de Las Rivas, Ismael Compañón, María Carmen Pallarés, Yun Kong, Javier Iglesias-Fernández, Gonçalo J L Bernardes, Jesús M Peregrina, Carme Rovira, Pau Bernadó, Pierpaolo Bruscolini, Henrik Clausen, Anabel Lostao, Francisco Corzana, Ramon Hurtado-Guerrero].
Get this from a library! Cell surface carbohydrate chemistry. [Robert E Harmon; American Chemical Society. Division of Carbohydrate Chemistry.;]
Hello, I have a live Helix pomatia snails for sale. Price $ 4.50 for one snail. If you buy 10 or more - price would be $ 4 for each one. We proudly ship
1FIH: Mechanism of pH-dependent N-acetylgalactosamine binding by a functional mimic of the hepatocyte asialoglycoprotein receptor.
Zheng T., Peelen D., Smith L.M. 2005. Lectin arrays for profiling cell surface carbohydrate expression. Journal of the American Chemical Society. 127:9982-9983. ...
Zheng T., Peelen D., Smith L.M. 2005. Lectin arrays for profiling cell surface carbohydrate expression. Journal of the American Chemical Society. 127:9982-9983. ...
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Dolichos biflorus|/em| agglutinin is a glycoprotein with a molecular weight of about 111 kDa and consists of 4 subunits of approximately equal size. This lectin has a carbohydrate specificity toward α-linked N-acetylgalactosamine.
Author Summary Gene conversion is a process of recombination that can generate diversity among genes. Gene conversion occurs in some pathogenic species of protozoa to generate diversity among gene families encoding important antigens. The process may contribute to immune evasion by the parasites. Gene conversion, or indeed recombination of any kind, has not previously been demonstrated in human intestinal parasites of the genus Entamoeba. Here, we analysed genes encoding members of an important antigenic protein complex on the surface of Entamoeba parasites which is involved in invasion of the intestinal wall. Three gene families encode heavy-, light- and intermediate-subunits of the complex. We estimated genetic divergence between related genes from two species of Entamoeba, E. histolytica and E. dispar, and compared them to divergence among neighbouring genes and to the average across the whole genome, initially looking for evidence that the genes were evolving under positive selection. However,
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FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Glycosylation of proteins affects cell-cell interaction, interactions with the matrix, and the functions of intracellular molecules. ST6GALNAC1 transfers a sialic acid, N-acetylneuraminic acid (NeuAc), in an alpha-2,6 linkage to O-linked GalNAc residues. The cancer-associated sialyl-Tn (sTn) antigen is formed by ST6GALNAC1-catalyzed sialylation of GalNAc residues on mucins (Ikehara et al., 1999 [PubMed 10536037]; Sewell et al., 2006 [PubMed 16319059]).[supplied by OMIM, Mar 2008 ...
This lectin is a family of tetrameric glycoproteins consisting of combinations of A and B subunits similar in structure to PHA and GSL I.
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Biology of Reproduction contains original scientific research on a broad range of topics in the field of reproductive biology, as well as minireviews.
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