A valuable source of information for scientists in microbiology, biotechnology and renewable energy Covers the current knowledge in the field of

Date: Tue, 5 Aug 2014 09:57:34 -0400 From: Susan Gottesman [[email protected]] Subject: Summer Break: NEXT TALK AUG. 21 To: [[email protected]] SIXTH FLOOR RENOVATION POSTPONED UNTIL SEPTEMBER: MEET IN THE USUAL PLACE UNTIL FURTHER NOTICE. 8/21/14* Somenath Bakshi (U of W, Madison, Weishaar Lab) How does transcription and translation modulate nucleoid morphology? (Dhruba Chattoraj) 8/25/14: 2:00 PM, Bldg. 37, Rm. 6107 (lambda lunch room): Joerg Vogel (U. Wurzburg) A new global RNA-binding protein and its associated small RNAs (Susan Gottesman, Gigi Storz) 8/28/14*: Meeting reviews (Microbial Stress Gordon Conference, Phage Meetings, ....). 9/4/14*: Vic Sivanathan (A. Hochschild lab) An E. coli-based assay for studying and identifying amyloidogenic proteins (Gigi Storz) 9/11/14*: Lars Dietrich (Columbia) (Kumaran Ramamurthi) 10/9/14*: Andrew Camilli (Tufts University) (Matthais Machner) 10/23/14*: George Liechtl (Tony Maurelli lab, USUHS): Peptidoglycan biosynthesis and ...

The influence of carbon dioxide and oxygen on microbial secondary metabolite producers and the maintenance of these two parameters at optimal levels have been studied extensively. Nevertheless, most studies have focussed on their influence on specific product formation and condition optimization of established processes. Considerably less attention has been paid to the influence of reduced or elevated carbon dioxide and oxygen levels on the overall metabolite profiles of the investigated organisms. The synergistic action of both gases has garnered even less attention. We show that the composition of the gas phase is highly important for the production of different metabolites and present a simple approach that enables the maintenance of defined concentrations of both O2 and CO2 during bioprocesses over broad concentration ranges with a minimal instrumental setup by using endogenously produced CO2. The metabolite profiles of a myxobacterium belonging to the genus Chondromyces grown under various

X-SBRS-Extended: Low X-IronPortListener: NIH_Relay X-SBRS: None Date: Sun, 10 Apr 2016 13:31:06 -0400 Reply-To: Susan Gottesman [[email protected]] From: Susan Gottesman [[email protected]] Subject: April 10 update To: [[email protected]] Precedence: list List-Help: [http://list.nih.gov/cgi-bin/wa.exe?LIST=LAMBDA_LUNCH-L], [mailto:[email protected]?body=INFO%20LAMBDA_LUNCH-L] List-Unsubscribe: [mailto:[email protected]] List-Subscribe: [mailto:[email protected]] List-Owner: [mailto:[email protected]] List-Archive: [http://list.nih.gov/cgi-bin/wa.exe?LIST=LAMBDA_LUNCH-L] Return-Path: [email protected] 4/14/16*: Blake Wiedenheft (Montana State University) A CRISPR Immune Response to Viruses that Infect Bacteria (G. Storz) 4/21/16*: Michael Ibba (Ohio State) Translation Quality Control And the Regulation of Microbial Stress Responses (G. Storz/S. Gottesman) 4/27/16: WALS: Man-Wah ...

Aim 1: Characterize the effect of spaceflight analogue culture on microbial pathogenesis related stress responses and in vitro host-pathogen interactions. Analysis will include microbial stress responses as well as colonization and viability following pathogen challenge of three-dimensional (3-D) tissue co-culture models containing immune cells.. Aim 2: Characterize the effect of spaceflight analogue culture on the virulence potential of pathogenic microorganisms. Changes in virulence will be assessed using a mouse model of infection. To reduce and refine the use of animals for virulence studies, the selection of microorganisms for Aim 2 will be based on a combination of microbial responses from Aim 1 and previously reported spaceflight and spaceflight analogue experimental data of similar microorganisms.. Aim 3: Profile the synergistic relationship between spaceflight analogue-altered bacterial virulence characteristics and spaceflight analogue-altered immune cell function. Alterations in ...

Cellular adaptation to microbial stresses has been demonstrated in several cell types. Macrophages (MФ) are sentinel immune cells fending off invading microbes. Anthrax lethal toxin (LeTx) is a key virulence factor released by Bacillus anthracis that causes rapid cell death, pyroptosis. A small number of RAW246.7 macrophages (~4%) exposed to a non-lethal dose of LeTx become resistant to LeTx-induced pyroptosis for ~ 4 weeks, termed

Cardenolide is a type of steroid. Many plants contain derivatives, collectively known as cardenolides, including many in the form of cardenolide glycosides (cardenolides that contain structural groups derived from sugars). Cardenolide glycosides are often toxic; specifically, they are heart-arresting. The term derives card- heart (from Greek καρδία kardiā) and the suffix -enolide, referring to the lactone ring at C17. It should not be confused with cardanolides. Cardanolides are a class of steroids (or aglycones if viewed as cardiac glycoside constituents), and cardenolides are a subtype of this class (see MeSH D codes list). Cardenolides are C(23)-steroids with methyl groups at C-10 and C-13 and a five-membered lactone (specifically a butenolide) at C-17. They are aglycone constituents of cardiac glycosides and must have at least one double bond in the molecule. The class includes cardadienolides and cardatrienolides. Members include: acetyldigitoxins acetyldigoxins cymarine digitoxin ...

Research. Dr. Weizhe Hong is an Assistant Professor in the Department of Biological Chemistry and the Department of Neurobiology at UCLA David Geffen School of Medicine. Dr. Hong received a B.S. degree in biological sciences at Tsinghua University. When he was in high school and college, he worked with Zengyi Chang, on mechanisms of protein folding and microbial stress response, first at Tsinghua University and then at Peking University. He received his PhD degree in 2012 at Stanford University, under the guidance of Liqun Luo. His PhD research focused on the cellular and molecular mechanisms of wiring specificity during olfactory system development. He was a Helen Hay Whitney Fellow in David Andersons Laboratory, working on neural mechanisms underlying social and emotional behaviors. Dr. Hong received the Genetics Society of Americas Larry Sandler Memorial Award for the best PhD dissertation on the Drosophila research, and presented the Larry Katz Memorial Lecture in the Cold Spring Harbor ...

Cats and dogs are the most the popular pets around the world. But they are also predators. Do we have to change the way we live with them to protect nature?