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acetanilide definition: a white, crystalline organic substance, CHNHCOCH, produced by the action of acetic acid on aniline: it is used as a drug to lessen pain and fever, in making dyes, etc.Origin of acetanilide acet(o)- + anil(ine) + -ide...
3-(N,N-Diethylamino)acetanilide 6375-46-8 NMR spectrum, 3-(N,N-Diethylamino)acetanilide H-NMR spectral analysis, 3-(N,N-Diethylamino)acetanilide C-NMR spectral analysis ect.
4-Amino-3-(trifluoromethyl)acetanilide 1579-89-1 NMR spectrum, 4-Amino-3-(trifluoromethyl)acetanilide H-NMR spectral analysis, 4-Amino-3-(trifluoromethyl)acetanilide C-NMR spectral analysis ect.
The structure and activity of peptides and proteins strongly rely on their charge state and the interaction with their hydration environment. Here, infrared photodissociation (IRPD) spectra of size-selected microhydrated clusters of cationic acetanilide (AA+, N-phenylacetamide), AA+-(H2O)n with n ≤ 3, are an Complex molecular systems: supramolecules, biomolecules and interfaces
Wavelengths of spectra for Acetanilide ranges from 3300 cm-1 to 1700 cm-1. This is because of the bonds that are formed within the Acentanilide chemical...
The effects of ranolazine on cardiac ion currents at concentrations within the therapeutic range (ie, 2 to 6 μmol/L) include inhibition of IKr, late INa, and late ICa,L. Inhibition of IKr by ranolazine prolongs APD, and its effect to inhibit late INa and late ICa,L abbreviates APD. The net effect and clinical consequence of inhibition of these ion channel currents is a modest increase in the mean QTc interval over the therapeutic range. The drug differs significantly from other agents that block IKr and induce TdP. Ranolazine-induced prolongation of the APD is rate independent (ie, does not display reverse rate-dependent prolongation of APD) and is not associated with EADs, triggered activity, an increase in spatial dispersion of repolarization, or polymorphic ventricular tachycardia. Indeed, rather than displaying arrhythmogenic activity, ranolazine, via its actions to suppress EADs and reduce TDR, possesses significant antiarrhythmic activity, acting to suppress the arrhythmogenic effects ...
Heart failure is a leading cause of cardiovascular mortality with limited options for treatment. We analyzed whether the anti-ischemic drug ranolazine could retard the progression of heart failure in an experimental model of heart failure induced by 6 months of chronic pressure overload. The study showed that 2 months of ranolazine treatment improved cardiac function of aortic constricted C57BL/6J (B6) mice with symptoms of heart failure as assessed by echocardiography. The microarray gene expression study of heart tissue from failing hearts relative to ranolazine-treated and healthy control hearts identified heart failure-specific genes that were normalized during treatment with the anti-ischemic drug ranolazine Show more ...
Of the 6, acetanilide and aniline will have the highest melting points as they are polar. Between the two, I reasoned that acetanilide will have a higher melting point because it has a polar carbonyl group in addition to the h-bonding provided by the nitrogen bonded to a hydrogen. This stands in contrast to the mere nitrogen bonded to two hydrogens in the aniline. I have to admit, my reasoning here is fuzzy. As it stands, Im comparing carbonyl & N-H (acetanilide) to N-H & N-H (aniline). How do we know that dipole + hydrogen bonding is better than hydrogen bonding + hydrogen bonding? I know that hydrogen bonding is a stronger intermolecular interaction than dipole-dipole or dipole-hydrogen bond ...
thats if you want to run this reaction by one step formation reaction,..i mean if you want to obtain Acetanilide from Aniline this is the only step you should take over..but if you mean anything else the chemistry converting puzzle(obtaining Acetanilide from Anillinium Hydrochloride) it would certainly differ..we should first eliminate the (-NH3+Cl-) group from the benzene ring..by a very strong agent and under extreme conditions..then from benzene we will obtain the Aniline easily from sand-mayer rx, then finally we would reach the final normal step of Acetanilide formation that i told you about it (rx with Acetyl Chloride ...
Recently, there has been interest in the antiarrhythmic potential of the novel antianginal agent, ranolazine, the first Food and Drug Administration-approved drug that specifically blocks the late component of the Na+ current. Like most antiarrhythmics that target cardiac ion channels (eg, flecainide and amiodarone), ranolazine blocks multiple channels, including the repolarizing hERG current IKr, with therapeutic concentrations. The result is a mild concentration-dependent QTc prolongation seen in patients with chronic stable angina.11 Because of this, ranolazine is contraindicated for patients using other QT-prolonging drugs, those with preexisting QT prolongation,12 and those with repolarization abnormalities.. In this study, we sought to use a computationally based approach to determine whether ranolazines unintended pathological block of promiscuous K+ channels would prevail over therapeutic drug effects in 2 specific patient populations: LQT3-ΔKPQ carriers and those with acquired ...
Looking for MERLIN-TIMI 36? Find out information about MERLIN-TIMI 36. in Arthurian legend Arthurian legend, the mass of legend, popular in medieval lore, concerning King Arthur of Britain and his knights. Medieval Sources The... Explanation of MERLIN-TIMI 36
BIOACCUMULATION AND RISK ASSESSMENT OF BUTACHLOR IN THE SOIL ECOSYSTEM. ABSTRACT. Bioaccumulation of butachlor in plants following its application in the farm against weeds was evaluated using Phaseolus vulgaris (bean plant). Also, the risk of the consumption of such plants with some amount of bioaccumulated butachlor by non-target humans was studied using rabbits as animal model. The field experiments were carried out by crop cultivation with the application of 4.0 liters per hectare (2.6 kg a.i/ha), 4.4 liters per hectare (2.9 kga.i/ha) and 5.0 liters per hectare (3.2 kg a.i/ha) concentrations of butachlor at pre-emergence of the bean plant and the leaves of the plant were analyzed for the presence of butachlor residues using GC-MS , the result gave 0.10, 0.13 and 0.20 ppm bioaccumulated butachlor respectively for the concentrations of the butachlor applied to the plots of land. For 28 days three replicate groups of rabbits (4 per group) were fed the leaves containing these different ...
Ranolazine is a novel antianginal that may also have a favorable effect on hemoglobin A1c (HbA1c). We designed a prospective evaluation of the effect of ranolazine on hyperglycemia as part of the randomized, double-blind, placebo-controlled Metabolic Efficiency With Ranolazine for Less Ischemia in Non-ST-Elevation Acute Coronary Syndromes-Thrombolysis in Myocardial Infarction 36 (MERLIN-TIMI 36) trial and compared HbA1c (percentage) among 4918 patients with acute coronary syndrome randomized to ranolazine or placebo. We found that ranolazine significantly reduced HbA1c at 4 months compared with placebo in patients with and without diabetes mellitus. In patients with diabetes mellitus treated with ranolazine, HbA1c declined 0.64% (P,0.001). In addition, diabetic patients treated with ranolazine were more likely to achieve an HbA1c ,7% at 4 months (P,0.001). Notably, in patients without diabetes mellitus at baseline, the incidence of new fasting glucose ,110 mg/dL or HbA1c ≥6% was reduced by 32% ...
The crude p-acetaminobenzenesulfonyl chloride (p. 8) obtained from 67.5 g. (0.5 mole) of acetanilide is shaken for two hours with a solution of 252 g. (1 mole) of crystallized sodium sulfite (Na2SO3 · 7H2O) in 500 cc. of water. The reaction mixture is kept slightly alkaline by the addition at intervals of small portions of 50 per cent sodium hydroxide solution. The total volume of alkali used varies from 10 to 50 cc. After the alkaline mixture has been shaken for the two-hour period (Note 1) it is filtered, and the filtrate is acidified with 60 per cent sulfuric acid. If the acid is added slowly, the sulfinic acid comes down in fine crystals which, after filtering and drying, melt at 155° with decomposition (Note 2). The yield is 50-55 g.. (43-47 per cent of the theoretical amount based on the acetanilide used ...
The Gibbs free energy, enthalpy and entropy of partitioning of 45 simple aromatic compounds (phenols, benzoic acids and acetanilides) from water to octanol and from water to cyclohexane have been determined using the filter-probe method. This involved the measurement of partition coefficients over the temperature range 20-45oC. The aim of the work was to explore the effects of intramolecular hydrogen bonding and steric factors on the partitioning process. It was found that the intramolecular hydrogen bond is intact in 2-nitrophenol and salicylic acid, and possibly in 2-hydroxybenzaldehyde, in all three solvents, but 2-chlorophenol is intramolecularly hydrogen bonded only in inert solution. The evidence indicates that 2-nitroresorcinol and 2,6-dihydroxybenzoic acid possess only one intramolecular hydrogen bond, although they are theoretically capable of possessing two. There is evidence of steric shielding in 2,6-dimethylphenol, whilst 2,6-dimethylbenzoic acid and ortho-substituted acetanilides show
This bottle contains a mixture of Acetanilide and Lysol. Acetanilide is a compound drug used for fever-reducing since 1886 as an alternative to aspirin for treating headaches, cramps, and rheumatism. It does have toxic side effects from prolonged use such as complicating the function of hemoglobin. Lysol was first used in Germany in 1889 to end a cholera epidemic. It is a mixture of soap with cresols as an antiseptic. Before its use as a cleaner, it has been used as a poison, to treat the Spanish flu of 1918, and as a method of birth control in women in the 1920s. This bottle is half-filled with the liquid ...
Eye Contact: Any contact lenses should be removed immediately in case of accidental eye contact. One should flush the eyes with plenty of water at least for 15 minutes. Immediate medical aid is required.. Skin Contact: Victim should wash the contaminated skin area with disinfectant soap and water before applying an emollient lotion to it. It is important to get immediate medical assistance.. Inhalation: The victim should be removed to fresh air in case of accidental inhalation of this powder. Oxygen and artificial respiration should be provided in case the victim is experiencing breathing problems. One should immediately seek medical attention.. Ingestion: It is not advisable to induce vomiting without proper direction from a qualified physician. Any tight clothing like tie, collar and waistband should be loosened. One should never give anything by mouth if the victim is unconscious. Immediate medical assistance is important.. ...
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The ability of butachlor to induce cytotoxicity, clastogenicity and DNA damage was assessed using Chinese hamster ovary cells (CHO), Swiss mouse embryo fibroblasts (MEF) and human peripheral blood lymphocytes. A dose and time dependent loss of viability was evident upon treatment of CHO cells with butachlor. Cell killing to an extent of 50 % was observed when cells were treated with 16.2 μg/ml of butachlor for 24 hr or with 11.5 μg/ml for 48 hr. The herbicide induced micronuclei significantly in cultured lymphocytes at 24 and 48 hr of treatment suggesting that it is clastogenic. To understand the mechanism of cell death caused by butachlor, its effect on DNA strand breaks was studied in MEF. A concomitant decrease in cell viability was observed with increase in DNA strand breaks. Agarose gel electrophoresis of DNA from herbicide treated CHO cells and cytochemical staining indicate the induction of apoptosis by butachlor ...
Background:. Patients with ischemic heart disease often report multiple symptoms, including angina and palpitations.. Ranolazine is a novel antianginal and antiischemic drug that reduces intracellular sodium and calcium accumulation during ischemia thus limiting ischemic injury. Furthermore, ranolazine has antiarrhythmic effects which are largely a result of the drugs effect on multiple ion channels.. It has previously been shown that treatment with ranolazine can reduce the frequency of supraventricular and ventricular tachycardia in the short term. In a subgroup analysis of the MERLIN-TIMI 36 trial, the continuous ECGs of 6,351 patients were analyzed. The results showed that, in comparison with placebo, treatment with ranolazine resulted in fewer episodes of ventricular tachycardia that lasted 8 beats or longer (5.3% versus 8.3%; P ,0.001), and in fewer episodes of supraventricular tachycardia (44.7% versus 55%; P ,0.001) and new-onset atrial fibrillation (1.7% versus 2.4%; P=0.08).. It ...
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TY - JOUR. T1 - An emerging antiarrhythmic target. T2 - Late sodium current. AU - Banyasz, T.. AU - Szentandrássy, N.. AU - Magyar, J.. AU - Szabo, Z.. AU - Nánási, P. P.. AU - Chen-Izu, Ye. AU - Izu, Leighton T. PY - 2015/1/1. Y1 - 2015/1/1. N2 - The cardiac late sodium current (INa,L) has been in the focus of research in the recent decade. The first reports on the sustained component of voltage activated sodium current date back to the seventies, but early studies interpreted this tiny current as a product of a few channels that fail to inactivate, having neither physiologic nor pathologic implications. Recently, the cardiac INa,L has emerged as a potentially major arrhythmogenic mechanism in various heart diseases, attracting the attention of clinicians and researchers. Research activity on INa,L has exponentially increased since Ranolazine, an FDA-approved antianginal drug was shown to successfully suppress cardiac arrhythmias by inhibiting INa,L. This review aims to summarize and discuss ...
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The primary objective is to assess whether the increased angina threshold on ranolazine and subsequent higher training intensity will result in improved exercise tolerance and oxygen consumption; and greater than that observed with exercise training on placebo. The study team anticipates the chronic exercise improvements with ranolazine will be incrementally higher than the acute effects provided by ranolazine alone and demonstrated in previous trials. Key secondary objectives include the acute ranolazine and chronic exercise plus ranolazine effects on total daily energy expenditure (TDEE) and angina-related quality of life ...
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Several series of ligands, designed to chelate silver(I) specifically in the presence of base metals, have been synthesised. The ligands include: - dithiodiamide compounds, prepared by the condensation of acetanilide derivatives with 1,2-dibromoethane; propanenitrile and propanoic ester derivatives prepared from pyridine-2-carbaldehyde via the Morita-Baylis-Hillman reaction; and novel malonamide ligands from the reaction of diethyl malonate with a range of primary amines. The malonamide derivatives were prepared under both conventional thermal and microwave-assisted conditions, the latter proving to be highly efficient. The ligands were all characterised using a combination of spectroscopic and, where appropriate, elemental analysis; in one case, the structural assignment was confirmed by single-crystal X-ray analysis. The fragmentation patterns in the electron-impact mass spectra of the malonamide derivatives have been explored using high-resolution and meta-stable peak scanning ...
The log KOC of the three main components of the test item Reaction mass of N-butylphthalimide and N-propylphthalimide and N-sec-butylphthalimide was determined according to TG OECD 121. This determination is based upon a regression analysis of the log KOC values of reference items against their respective retention times as determined by HPLC analysis. The following reference items were used: Acetanilide, Phenol, Methyl benzoate, Naphthalene, 1,2,3-Trichlorobenzene and Pyrazophos. The dead time of the HPLC system was determined with Sodium nitrate. This set of reference items yielded a calibration with log KOC values ranging from 1.25 to 3.65 and retention times ranging from 3.34 min to 36.2 min. The dead time of the HPLC system was 1.10 min. The log KOC value for the first test item component (N-propylphthalimide) was found to be 2.10 (95% confidence limits: 1.99-2.20) in both determinations. The log KOC value for the second test item component (N-sec-butylphthalimide) was found to be 2.40 ...
Key value for chemical safety assessment Koc at 20 °C: , 18 Log Koc at 20 °C: , 1.26 The HPLC method at pH 2 and at pH 7 using soil-adsorption-reference data was applied for the determination of the adsorption coefficient (Koc) of the substance, in accordance with EC C.9 and OECD 121 and according to the principles of GLP. At pH 2, most of the substance will be in its non-ionised form. At pH 7, the test substance will be fully ionised. The HPLC chromatogram of the test substance showed one peak at 1.1 minutes at pH 2 and one peak at 0.5 minutes at pH 7. Under the same analytical conditions, the retention time of the reference substance Acetanilide (log Koc = 1.26) was higher at both pHs. Hence, it was concluded that the log Koc of the test substance at pH 2, as well as at pH 7, was , 1.26. ...
In the late 19th century, derivatives of aniline such as acetanilide and phenacetin emerged as analgesic drugs, with their cardiac-suppressive side effects often countered with caffeine.[26] During the first decade of the 20th century, while trying to modify synthetic dyes to treat African sleeping sickness, Paul Ehrlich - who had coined the term chemotherapy for his magic bullet approach to medicine - failed and switched to modifying Béchamps atoxyl, the first organic arsenical drug, and serendipitously obtained a treatment for syphilis - salvarsan - the first successful chemotherapy agent. Salvarsans targeted microorganism, not yet recognized as a bacterium, was still thought to be a parasite, and medical bacteriologists, believing that bacteria were not susceptible to the chemotherapeutic approach, overlooked Alexander Flemings report in 1928 on the effects of penicillin.[27]. In 1932, Bayer sought medical applications of its dyes. Gerhard Domagk identified as an antibacterial a red azo ...
Acetanilide and derivatives of benzoic acid, benzamide, salicylic acid, and salicylamide were tested as inhibitors of p-aminobenzoic acid N-acetyltransferase partially purified from peripheral blood of three rapid and two slow dapsone acetylator human volunteers. The 50% inhibition point of these compounds does not provide a kinetic basis for differentiating the rapid and slow dapsone acetylator phenotypes. ...
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Abaca (n.) The Manila-hemp plant (Musa textilis); also, its fiber. See Manila hemp under Manila.. Abigail (n.) A ladys waiting-maid.. Abreast (adv.) Side by side; also, opposite; over against; on a Abstain (v. i.) To hold ones self aloof; to forbear or refrain voluntarily, and especially from an indulgence of the passions or appetites; -- with from.. Acciaccatura (n.) A short grace note, one semitone below the note to which it is prefixed; -- used especially in organ music. Now used as equivalent to the short appoggiatura.. Acerate (a.) Acerose; needle-shaped.. Acetabular (a.) Cup-shaped; saucer-shaped; acetabuliform.. Acetabulifera (n. pl.) The division of Cephalopoda in which the arms are furnished with cup-shaped suckers, as the cuttlefishes, squids, and octopus; the Dibranchiata. See Cephalopoda.. Acetabuliform (a.) Shaped like a shallow cup; saucer-shaped; as, an acetabuliform calyx.. Acetanilide (n.) A compound of aniAchlamydate (a.) Not possessing a mantle; -- said of certain ...
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The present invention relates to a use of a carbamate compound of formula 1, or a pharmaceutically acceptable salt, solvate or hydrate thereof in the prevention or treatment of diseases associated with an increase in late sodium current.
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Ranexa is the brand name of ranolazine, a prescription drug used to treat chronic angina; spasmodic attacks of intense chest pain that keep coming back.
Programmed electrical stimulation was performed in eight normal dogs using a stimulator and endocardiai electrode catheters identical to those used in human studies. The right and left ventricular apex were paced at a drive cycle length of 400 ms and, in some cases, 500 ms, with a pacing sequence of single (S1S2), double (S1S2S3) and triple (S1S2S3S4) premature impulses introduced after eight paced complexes. Pacing sequences were performed using combinations of pulse width (1, 2 and 4 ms) and current strengths of 2, 5 and 10 times diastolic threshold, and in three dogs, 15 times diastolic threshold.. Twenty-two episodes of ventricular fibrillation were initiated in five dogs in 170 pacing sequences using current strengths up to 10 times diastolic threshold, and six episodes of ventricular fibrillation in the two of three remaining dogs tested at 15 times diastolic threshold. Ventricular fibrillation was reproducible on seven of nine occasions. Ventrieular fibrillation was never induced by ...
The present study was undertaken to evaluate the influence of butachlor, a widely used herbicide, on antioxidant enzyme system and lipid peroxidation formation in African cat fish (Clarias gariepinus). Fish were exposed to sub-lethal concentrations of butachlor 1, 2, 2.5 ppm and sacrificed 24hrs after treatment. A significant increase in malondialdehyde formation was observed in the liver, kidney, gills and heart of the fish following exposure to different concentrations of butachlor. Superoxide dismutase and catalase activities increased in the liver and kidney but decreased in the gills and heart in a concentration-dependent pattern. Glutathione level and glutathione-Stransferase activities increased (P
Two types of human hepatic enzyme are involved in the biotransformation of riluzole by the human liver in vitro: monooxygenases and UDP-glucuronosyltransferases. Quantitatively, monooxygenation is possibly the more important reaction because intrinsic clearance via this route was 30-fold higher than that via direct glucuronidation.. Riluzole N-hydroxylation was the only monooxygenase-mediated reaction observed with human hepatic microsomes. CYP1A2 appears to be the main isoenzyme involved in this reaction, a conclusion that is based on the potent inhibition observed with the specific CYP1A2 inhibitor α-naphthoflavone (IC50 = 0.42 μM), the specific biotransformation noted with genetically expressed CYP1A2, and the competitive inhibitory effect of riluzole on CYP1A2-catalyzed methoxyresorufin O-demethylation. The relatively weak inhibitory effect of the CYP1A2 substrates caffeine and acetanilide on riluzole N-hydroxylation may be attributed to the low affinity of these compounds for CYP1A2 (K m ...
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The objective of this study was to determine the Adsorption Coefficient of the test item 10- UNDENECENOIC AClD applying the procedure described in the OECD Guideline 121 Adsorption Coefficient on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC). At the test conditions (HPLC), the adsorption coefficient of 10-UNDENECENOIC AClD was found to be log Koc = 2.84 (Koc = 691.83). This result is close to the log Koc 2.77 of reference substance acetanilide, which represents the lower end of adsorption values of the reference substances used. Therefore, the adsorption potential of the test item is considered low. ...
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In this trial of patients with T2DM, established CAD, and stable angina, ranolazine was more effective than placebo in reducing the primary outcome of average weekly angina episodes, as well as average weekly sublingual nitroglycerin use. These results were consistent across the subgroups of baseline average weekly angina episodes, number of concomitant antianginal medications, age, and sex. The therapeutic benefit of ranolazine versus placebo was greater among patients enrolled outside of Russia, Ukraine, and Belarus, and among those with higher baseline HbA1c. In addition, ranolazine was safe and well tolerated in this patient population.. While patients with T2DM and CAD have more extensive disease (7,8) and worse outcomes (20,21) than those without DM, the data on whether they experience more angina are conflicting. Several older studies suggested that patients with DM have less angina than their non-DM counterparts due to an increased likelihood of silent ischemia related to diabetic ...
Accordingly, the Metabolic Efficiency with Ranolazine for Less Ischemia in Non-ST Elevation Acute Coronary Syndromes (MERLIN TIMI-36) study, presented today at the American College of Cardiologys 56th Annual Scientific Session, had the dual objectives to provide new long-term safety data on ranolazine in a high-risk population of patients with acute coronary syndromes (ACS) and to study the drugs efficacy in a broad population of people with unstable angina due to ACS. ACC.07 is the premier cardiovascular medical meeting, bringing together cardiologists and cardiovascular specialists from around the world to further breakthroughs in cardiovascular medicine. The efficacy data showed that ranolazine did not produce a statistically significant reduction in the composite endpoint of cardiovascular death, heart attack and recurrent ischemia (the primary efficacy endpoint of the study), but did show a statistically significant reduction in recurrent ischemia alone. The data showed no adverse trend ...
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Results: Ranolazine was investigated by an extensive clinical study programme in patients with angina pectoris as monotherapy and as add-on therapy together with classical antianginal drugs. Ranolazine 500/1000/1500 mg twice daily monotherapy prolonged exercise duration significantly versus Placebo (MARISA study). The ERICA study demonstrated a significant reduction of the number of weekly angina pectoris attacks with Ranolazine (1000 mg twice daily) as add-on to amlodipine (10 mg/day). In patients with very frequent angina pectoris attacks, the effect of ranolazine was particularly pronounced. In the CARISA study, ranolazine (750 mg or 1000 mg twice daily) increased exercise duration as well as the time until ST depression in ECG and reduced the number of weekly angina pectoris attacks in patients on atenolol, amlodipine or diltiazem background treatment. Also in patients receiving the maximally tolerated dose of the background therapy, ranolazine add-on reduced the number of weekly angina ...
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Ranolazin is indicated for the control of angina in patients with chronic stable coronary artery disease. Born as a metabolic modulator , ranolazine is now considered to be a late sodium current blocker . This review tries to summarize the mechanism of antianginal effects of ranolazine. ...
Arrhythmias arise from breakdown of orderly action potential (AP) activation, propagation and recovery driven by interactive opening and closing of successive voltage-gated ion channels, in which one or more Na+ current components play critical parts. Early peak, Na+ currents (I Na) reflecting channel activation drive the AP upstroke central to cellular activation and its propagation. Sustained late Na+ currents (I Na-L) include contributions from a component with a delayed inactivation timecourse influencing AP duration (APD) and refractoriness, potentially causing pro-arrhythmic phenotypes. The magnitude of I Na-L can be analysed through overlaps or otherwise in the overall voltage dependences of the steady-state properties and kinetics of activation and inactivation of the Na+ conductance. This was useful in analysing repetitive firing associated with paramyotonia congenita in skeletal muscle. Similarly, genetic cardiac Na+ channel abnormalities increasing I Na-L are implicated in triggering
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Background: Patients with coronary microvascular dysfunction (CMD) often have diastolic dysfunction, representing an important therapeutic target. Ranolazine-a late sodium current inhibitor-improves diastolic function in animal models and subjects with obstructive coronary artery disease (CAD). Hypothesis: We hypothesized that ranolazine would beneficially alter diastolic function in CMD. Methods: To test this hypothesis, we performed retrospective tissue tracking analysis to evaluate systolic/diastolic strain, using cardiac magnetic resonance imaging cine images acquired in a recently completed, randomized, double-blind, placebo-controlled, crossover trial of short-term ranolazine in subjects with CMD and from 43 healthy reference controls. Results: Diastolic strain rate was impaired in CMD vs controls (circumferential diastolic strain rate: 99.9% ± 2.5%/s vs 120.1% ± 4.0%/s, P = 0.0003; radial diastolic strain rate: −199.5% ± 5.5%/s vs −243.1% ± 9.6%/s, P = 0.0008, case vs control). ...
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TY - JOUR. T1 - Trattamento delle sindromi coronariche acute nel paziente anziano. T2 - Insegnamenti dellItalian Elderly ACS Study. AU - Savonitto, Stefano. AU - Antonicelli, Roberto. AU - Caraceni, Daniele. AU - DAmbrosi, Fabrizio. AU - De Servi, Stefano. PY - 2012/10. Y1 - 2012/10. N2 - Elderly patients account for one third of those admitted to cardiac care units with non-ST-elevation acute coronary syndromes, but are largely underrepresented in randomized clinical trials which form the basis of practice guidelines. Conducting trials in this patient population is especially difficult due to coexisting pathologies, informed consent issues, a perceived higher risk of interventional procedures, and complexity of follow-up. The Italian Elderly ACS Study has been a positive experience in terms of accepting this challenge, carrying it on with limited resources and delineating convincing results, although not statistically conclusive due to its final limited sample size. The indications from the ...
Romagnoli, A., Martuscelli, E., Sperandio, M., Arganini, C., De Angelis, B., Acampora, V., et al. (2010). Role of 64-slice cardiac computed tomography in the evaluation of patients with non-ST-elevation acute coronary syndrome. LA RADIOLOGIA MEDICA, 115, 341-353 ...
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Woman getting pregnant after her period Because sperm can live inside you for up to 5 days, you could have sex towards the end of your period and then. Sep 19, - Original question: I had unprotected sex and he ejaculated in me, and four days later I get my period. Could I still get pregnant since sperm lives in me for 5 days, What are the possibilities of getting pregnant 5 days.
At 9 days old, uZair is able to turn by himself. I placed him on his tummy in his cot. Few minutes later I came in the room and he was no longer on his tummy ...
A couple of years ago a few of my digital friends and I brought this space to life: The Synapse. A week later I wrote about it here. The site derives its orig…
The need arises A couple of years ago a few of my digital friends and I brought this space to life: The Synapse. A week later I wrote about it here. The site derives its origin directly from a frustrating… Continue Reading →. ...
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