Short-term toxicity to fish: The toxicity of N,N-dimethylacetamide to fish was investigated in a static test conducted according to DIN 38412, part 15 using Leuciscus idus as test organism (BASF AG, 1979; report no. 78/277). Based on nominal test concentrations the 96-h LC50 was found to be ,500 mg/L. These data were selected as key data in terms of the chemical safety assessment. In conclusion, N,N-dimethylacetamide (CAS 127-19-5) is concluded to be with high probability acutely not harmful to fish. Long-term toxicity to fish: No experimental data available. In Annex IX section 9.1.6 of Regulation (EC) No 1907/2006, it is laid down that chronic tests shall be proposed by the registrant if the chemical safety assessment indicates the need to investigate further the effects on fish. According to Annex I of this regulation, the chemical safety assessment triggers further action when the substance or the preparation meets the criteria for classification as dangerous according to Regulation ...
The PCILO quantum-chemical method with geometry optimization has been used to study rotation barriers of methyl groups in N-methylacetamide and N,N-dimethylacetamide. In all the cases studied, the eclipsed conformation have been found to be the most stable. Cis form of N-methylacetamide is less stable than the corresponding trans form by 2.0 kJ mol-1. Moreover, the PCILO method has been used to study linear n-mers (n = 4) of N-methylacetamide. On going from the dimer to tri- and tetramers, the hydrogen-bond energies have been found non-additive, and positive cooperativity has been observed. Finally, hydrogen-bond complexes have been studied which were formed by C=O groups of N-methylacetamide and N,N-dimethylacetamide with water, methanol or phenol as proton-donors. The said proton-donors have been found to act as breakers of inter-peptide hydrogen bonds N-H...O=C. The hydrogen bonds formed by methanol are somewhat stronger than those formed by water. In accordance with experiment, the strongest ...
Read "Inhibitory effect of hexamethylene bisacetamide on replication of human cytomegalovirus, Archives of Virology" on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.
2-(4-chloro-6-fluoro-1-indanylidene)-N-methylacetamide: an anti-inflammatory agent with both analgesic and central muscle relaxant activities; structure in first source
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Hydrogen bonding between |i|N, N|/i|-dimethylacetamide (DMA) and alcohols has been studied in carbon tetrachloride solution by an X-band Microwave bench at 936GHz. The dielectric relaxation time (τ) of the binary system are obtained by both Higasis method and Gopalakrishna method. The most likely association complex between alcohol and DMA is 1:1 stoichiometric complex through the hydroxyl group of the alcohol and the carbonyl group of amide. The results show that the interaction between alcohols and amides is 1:1 complex through the free hydroxyl group of the alcohol and the carbonyl group of amide and the alkyl chain-length of both the alcohols and amide plays an important role in the determination of the strength of hydrogen bond (O-H: C=O) formed and suggests that the proton donating ability of alcohols is in the order: 1-propanol < 1-butanol < 1-pentanol and the accepting ability of DMA.
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N-[2-(5-methoxy-2-phenyl-1H-indol-3-yl)ethyl]acetamide chemical properties, What are the chemical properties of N-[2-(5-methoxy-2-phenyl-1H-indol-3-yl)ethyl]acetamide 151889-03-1, What are the physical properties of N-[2-(5-methoxy-2-phenyl-1H-indol-3-yl)ethyl]acetamide ect.
N-[2-(pyrrol-1-ylamino)phenyl]acetamide 87948-01-4 NMR spectrum, N-[2-(pyrrol-1-ylamino)phenyl]acetamide H-NMR spectral analysis, N-[2-(pyrrol-1-ylamino)phenyl]acetamide C-NMR spectral analysis ect.
Acetamide has been detected near the center of the Milky Way galaxy.[5] This finding is potentially significant because acetamide has an amide bond, similar to the essential bond between amino acids in proteins. This finding lends support to the theory that organic molecules that can lead to life (as we know it on Earth) can form in space. In addition, acetamide is found infrequently on burning coal dumps, as a mineral of the same name.[6][7] ...
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This is a one-period, double-blind, single-center pharmacokinetic study of linezolid in patients with MDR or XDR tuberculosis treated with linezolid and an Optimized Background Therapy (defined as treatment with , 4 drugs with activity against tuberculosis to which the patients isolate is believed to be sensitive by history or based on drug sensitivity testing ...
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Agents that trigger cell differentiation are highly efficacious in treating certain cancers, but such approaches are not generally effective in most malignancies. Compounds such as DMSO and hexamethylene bisacetamide (HMBA) have been used to induce differentiation in experimental systems, but their mechanisms of action and potential range of uses on that basis have not been developed. Here, we show that HMBA, a compound first tested in the oncology clinic over 25 years ago, acts as a selective bromodomain inhibitor. Biochemical and structural studies revealed an affinity of HMBA for the second bromodomain of BET proteins. Accordingly, both HMBA and the prototype BET inhibitor JQ1 induced differentiation of mouse erythroleukemia cells. As expected of a BET inhibitor, HMBA displaced BET proteins from chromatin, caused massive transcriptional changes, and triggered cell-cycle arrest and apoptosis in Myc-induced B-cell lymphoma cells. Furthermore, HMBA exerted anticancer effects in vivo in mouse ...
Alfa Chemistry is the worlds leading provider for special chemicals. We offer qualified products for 1008063-80-6(ACETAMIDE,N-[2,3-DIHYDRO-1-(ISOPROPYL)-2-OXO-1H-INDOL-3-YL]-),please inquire us for 1008063-80-6(ACETAMIDE,N-[2,3-DIHYDRO-1-(ISOPROPYL)-2-OXO-1H-INDOL-3-YL]-).
Substituted 2-arylacetamides are very interesting compounds because of their structural similarity to the lateral chain of natural benzyl penicillin (Mijin et al., 2006, 2008). Amides are also used as ligands due to their excellent coordination abilities (Wu et al., 2008, 2010). The room temperature crystal structure of the title compound was reported without hydrogen atom coordinates in the orthorhombic space group Pna21 (Andreetti et al., 1968). We report herein on the crystal structure of the monoclinic polymorph that crystallized in space group P21/c.. The molecular structure of the title compound is illustrated in Fig. 1. Bond lengths are in normal ranges (Allen et al., 1987) but show slight changes from those reported for some similar acetamide derivatives viz., N-(4-chloro-1,3-benzothiazol-2-yl)-2-(3-methylphenyl)acetamide monohydrate (Praveen et al., 2011a), N-(3-chloro-4-fluorophenyl)-2,2-diphenylacetamide (Praveen et al., 2011b) and ...
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Sandoz Linezolid: Linezolid belongs to the family of medications called antibiotics. It is used to kill certain types of bacteria that cause infections in the abdomen, lungs (e.g., pneumonia), urinary tract, skin, and skin-structures (e.g., sweat glands, hair follicles). This medication works by killing bacteria or preventing their growth.
Sandoz Linezolid: Linezolid belongs to the family of medications called antibiotics. It is used to kill certain types of bacteria that cause infections in the abdomen, lungs (e.g., pneumonia), urinary tract, skin, and skin-structures (e.g., sweat glands, hair follicles). This medication works by killing bacteria or preventing their growth.
Product name: Zyvox. Active ingredient: Linezolid. Thumbnail sketch: Generic Zyvox is an oxazolidinone antibiotic that fights bacteria in the body. It works by interfering with the production of proteins needed by bacteria to grow.. Known As: Zyvox. Manufacturer: Cipla. Were to buy: Go to store. Payment method: Visa / MasterCard / Western Union. Delivery Time: 5-7 business days by Courier Service or 10-21 business days by Standard International Airmail. Bonus options: FREE pills! FREE shipping! Discounts! (up to 10%) & more.... ...
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Structure, properties, spectra, suppliers and links for: N-(3-Cyano-2-thienyl)-2-(4-methyl-1-piperazinyl)acetamide hydrochloride (1:1).
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N-[2-(1-Benzyl-2-methyl-1H-indol-3-yl)-ethyl]-acetamide | C20H22N2O | CID 672975 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
N-(3,4-dioxo-3,4-dihydro-2-naphthalenyl)acetamide - chemical structural formula, chemical names, chemical properties, synthesis references
Structure, properties, spectra, suppliers and links for: N-{2-[5-Methoxy(2,4,6-|sup>2|/sup>H|sub>3|/sub>)-1H-indol-3-yl]ethyl}acetamide.
2-(4-chlorophenyl)-2-(dimethylamino)acetamide - chemical structural formula, chemical names, chemical properties, synthesis references
You are viewing an interactive 3D depiction of the molecule 2-bromo-n-{(1e,4e)-3-methyl-4-[(phenylsulfonyl)imino]-2,5-cyclohexadien-1-ylidene}acetamide (C15H13BrN2O3S) from the PQR.
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621-88-5 - AOPRXJXHLWYPQR-UHFFFAOYSA-N - Acetamide, 2-phenoxy- - Similar structures search, synonyms, formulas, resource links, and other chemical information.
Ingredients: It is thought that up to 2% of people are colonized with the MRSA bacteria.. Clinical outcome was missing at follow-up in 37 linezolid recipients and 42 vancomycin recipients for the following reasons: death (n = 9 and n = 12), loss to follow-up and other administrative reasons (n = 11 and n = 16), isolation of Gram-negative pathogens only (n = 12 and n = 10), and adverse events (n = 5 and n = 4), respectively Has anyone had experience with Zyvox causing peripheral neuropathy in someone after only two lincocin uso veterinario 600 mg doses. take care Drug Shortage Digest+ GOOD NEWS. Linezolid is used to treat different types of bacterial infections, such as pneumonia, skin infections, and infections that are resistant to other antibiotics Linezolid may also be used for purposes not listed in this medication guide CLASS. Does anyone know if antibiotics are prescribed/congestion, fever, while you are on pred? Visit the FDA MedWatch website or call 1-800-FDA-1088. Features & ...
N-(2-(4-t-butylbenzyl)-3-(pivaloyloxy)propyl)-2-(3-fluoro-4-(methylsulfonylamino)phenyl)propionamide: a TRPV1 antagonist; structure in first source
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Sigma-Aldrich offers Aldrich-294640, (S)-4-Benzyl-2-oxazolidinone for your research needs. Find product specific information including CAS, MSDS, protocols and references.
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies. ...
This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration ...
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This patent search tool allows you not only to search the PCT database of about 2 million International Applications but also the worldwide patent collections. This search facility features: flexible search syntax; automatic word stemming and relevance ranking; as well as graphical results.
Specialty monomer with affinity for water and solvents. Available in convenient protective foil packages for lab scale, and in bulk quantities.
The National Institute of Standards and Technology (NIST) uses its best efforts to deliver a high quality copy of the Database and to verify that the data contained therein have been selected on the basis of sound scientific judgment. However, NIST makes no warranties to that effect, and NIST shall not be liable for any damage that may result from errors or omissions in the Database ...
Crystallise the acetamide repeatedly from absolute EtOH, EtOAc (m 160-161o) or H2O (m 159-160o). Dry it in vacuo over P2O5. [Beilstein 9 H 347, 9 III 2193, 9 IV 1632 ...
There are 310 ten-letter words containing A, C, 2E and M: ACCRUEMENT ACCUSEMENT ACETAMIDES ... TETRAMERIC TETRASEMIC TIMESCALES. Every word on this site is valid scrabble words. See other lists, beginning with or ending with letters of your choice.
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Murine erythroleukemia cells (MELC) are transformed cells that can be induced to differentiate by a variety of agents, such as hexamethylenebisacetamide (HMBA) and dimethyl sulfoxide. Dexamethasone suppresses HMBA-mediated MELC differentiation, but MELC retain a memory for their exposure to HMBA since, on transfer from culture with HMBA and dexamethasone to medium without additions, a portion of the cells express characteristics of terminal differentiation. This study characterizes the steroid suppressed steps in the multi-step process of inducer-mediated MELC terminal differentiation. MELC in culture with HMBA and dexamethasone show low levels of commitment to terminal cell division; upon transfer to culture with inducer alone there is a rapid increase in the proportion of committed cells. The magnitude of this rapid or "step-up" expression of commitment increased with the length of prior culture with inducer and steroid. This step-up expression is not inhibited by actinomycin D or cordycepin ...
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Linezolid resistance in the absence of oxazolidinone exposure and surveillance.As described previously, MRSA CM-05 did not exhibit any mutations in domain V of the 23S rRNA (28). The identification of the cfr gene, which encodes an rRNA methylase, in this isolate recovered from a patient after such a short exposure to linezolid (28) indicates that the gene was also most likely acquired by the isolate under a selective pressure that did not involve exposure to oxazolidinones. An alternative explanation is that the strain was selected in an unidentified patient exposed to linezolid and was then passed on to the case patient. However, we did not find any evidence of the presence of cfr in any of the clinical isolates of MRSA previously recovered in Colombia or isolated around the time that the first isolate was discovered (see below), making this alternative possibility less likely. Although linezolid resistance in the absence of oxazolidinone exposure had been documented in Enterococcus spp. (2, ...
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The study aim was to explore local anesthetic properties of some tertiary and quaternary derivatives of dimethylacetamide. Materials and methods. The study was performed on white laboratory mice and rats of both sexes, male Agouti guinea pigs, and isolated sciatic nerves of lake frog. In the focus of the study there were two quaternary and eight tertiary compounds of dimethylacetamide with substituted anion with some amino and carbonic acids residue. A local anesthetic property was predicted by computational analysis. Acute toxicity of the most promising substances was studied in mice through subcutaneous route. Local anesthetic activity of tertiary compounds LKhT-3-00, LKhT-4-00 and quaternary LKhT-12-02 was studied on models of terminal, infiltration and conduction anesthesia. The influence of substances on mixed nerve conduction was investigated on lake frogs isolated sciatic nerves. Results and discussion. The greatest probability of the local anesthetic activity during