5-hydroxy-L-tryptophan 4350-09-8 NMR spectrum, 5-hydroxy-L-tryptophan H-NMR spectral analysis, 5-hydroxy-L-tryptophan C-NMR spectral analysis ect.

Amino acid decarboxylation activity in dispersed rat pancreas acinar cells and fractions derived by differential centrifugation of homogenate of these cells was studied. The rate of decarboxylation was measured by determining the rate of production of the [3H]-amine from [3H]-amino acid or the rate of production of 14CO2 from the [14C]-carboxy-labelled amino acid. Only the hydroxylated amino acids L-dopa and 5-hydroxytryptophan are decarboxylated by intact dispersed pancreas acinar cells or cell homogenates at all pH values and amino acid concentrations tested. The decarboxylase activity is located exclusively in the cell cytosol. Each substrate competitively inhibits the decarboxylation of the other and the decarboxylation of each is inhibited by NSD-1055. The estimated Km and Vmax are, for L-dopa, 4.8 X 10(-5) M and 2.5 nmol/mg protein/min and for 5-hydroxytryptophan, 2.9 X 10(-5) M and 0.3 nmol/mg protein/min. The pH optimum for 5-hydroxytryptophan decarboxylation is from 7.0-8.5 while that for L

TY - JOUR. T1 - Effects of l-dihydroxyphenylalanine (l-Dopa) and d,l,5-hydroxytryptophan (d,l,5-HTP) on reserpine-induced amnesia. AU - Palfai, Tibor. AU - Walsh, Thomas J.. AU - Albala, Bruce J.. AU - Brown, Oliver M.. PY - 1977/1. Y1 - 1977/1. N2 - In a series of experiments the effects of reserpine, l-Dopa, and d,l,5-hydroxytryptophan (d,l,5-HTP) on retention of a passive avoidance training in mice were investigated. Reserpine (2.5 mg/kg) produced amnesia when given at 120 min before but not at 30 min before or at 0, 10, 30, or 90 min following training. This time-dependent reserpine effect did not appear to be due to either an alteration in footshock sensitivity during training or to the drug producing state-dependent learning. The amnesic effect of reserpine could be blocked when both l-Dopa and d,l,5-HTP were also administered up to 10 min but not at 30 or 90 min following training. The drugs, l-Dopa or d,l,5-HTP, given alone or in higher doses, could not at any time counteract the ...

Enhances brain serotonin 5-Hydroxytryptophan (5-HTP) is an intermediate in the natural synthesis of the essential amino acid, tryptophan, to serotonin. The enzyme tryptophan hydroxylase adds a hydroxyl group (OH) to tryptophan, forming the 5-HTP intermediate. In the body, it converts to serotonin with the removal of a carboxyl group (COOH) by a second enzyme. Serotonin is an important neurotransmitter involved in the regulation of endocrine and brain activity responsible for emotion, appetite and sleep/wake cycles. In clinical studies, administration of 5-HTP supported serotonin production. The 5-HTP supplied in this supplement is derived from the Griffonia simplicifolia plant. Supplementation with 5-HTP encourages brain serotonin levels that can lead to positive effects on emotional well-being, appetite control, and wake/sleep cycles. each vegetable capsule contains: 5-hydroxytryptophan (Griffonia simplicifolia) 100 mg. (hypo-allergenic plant fiber added to complete capsule

5-HTP (5-hydroxytryptophan) 5-HTP specifications & features from suppliers/manufacturer 5-Hydroxytryptophan or 5-HTP Effective Scientifically Proven Weight Loss SupplementControl Hunger Cravings, Binge Eating, Compulsive Eating and Excessive HungerA major obstacle to successful weight loss programs is the tendency toward bingeeating dur

i] Hinz M., Stein A., Uncini T. 5-HTP efficacy and contraindications.Neuropsychiatric Disease and Treatment. 2012;8:323-8. (source). [ii] Turner E.H., Loftis J.M., Blackwell A.D. Serotonin a la carte: supplementation with the serotonin precursor 5-hydroxytryptophan.Pharmacology and Therapeutics. 2006 Mar;109(3):325-38. (source). [iii] Birdsall T.C. 5-Hydroxytryptophan: a clinically-effective serotonin precursor. Alternative Medicine Revue. 1998 Aug;3(4):271-80. (source). [iv] Lemaire P.A., Adosraku R.K. An HPLC method for the direct assay of the serotonin precursor, 5-hydroxytrophan, in seeds of Griffonia simplicifolia. Phytochemical Analysis. 2002 Nov-Dec;13(6):333-7. (source). [v] Emanuele E., Bertona M., Minoretti P., Geroldi D. An open-label trial of L-5-hydroxytryptophan in subjects with romantic stress. Neuro Endocrinology Letters. 2010;31(5):663-6. (source). [vi] Hinz M., Stein A., Uncini T. APRESS: apical regulatory super system, serotonin, and dopamine interaction. ...

i] Hinz M., Stein A., Uncini T. 5-HTP efficacy and contraindications.Neuropsychiatric Disease and Treatment. 2012;8:323-8. (source). [ii] Turner E.H., Loftis J.M., Blackwell A.D. Serotonin a la carte: supplementation with the serotonin precursor 5-hydroxytryptophan.Pharmacology and Therapeutics. 2006 Mar;109(3):325-38. (source). [iii] Birdsall T.C. 5-Hydroxytryptophan: a clinically-effective serotonin precursor. Alternative Medicine Revue. 1998 Aug;3(4):271-80. (source). [iv] Lemaire P.A., Adosraku R.K. An HPLC method for the direct assay of the serotonin precursor, 5-hydroxytrophan, in seeds of Griffonia simplicifolia. Phytochemical Analysis. 2002 Nov-Dec;13(6):333-7. (source). [v] Emanuele E., Bertona M., Minoretti P., Geroldi D. An open-label trial of L-5-hydroxytryptophan in subjects with romantic stress. Neuro Endocrinology Letters. 2010;31(5):663-6. (source). [vi] Hinz M., Stein A., Uncini T. APRESS: apical regulatory super system, serotonin, and dopamine interaction. ...

5-HTP, the intermediate metabolite between the amino acid L-tryptophan and serotonin, is extracted from the bean of an African plant (Griffonia simplicifolia).

Metabolic Maintenance Products has manufactured nutritional supplements through pioneering processes and unparalleled quality control measures that set the industrys standards.

Metabolic Maintenance Products has manufactured nutritional supplements through pioneering processes and unparalleled quality control measures that set the industrys standards.

Definition of N-acetyl-6-hydroxytryptophan oxidase with photos and pictures, translations, sample usage, and additional links for more information.

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Is 5-hydroxytryptophan safe? This part of the eMedTV library takes an in-depth look at this question and highlights some important warnings and precautions with 5-hydroxytryptophan. This page also explains why many doctors do not recommend the product.

BACKGROUND Autism is accompanied by peripheral and central disorders in the metabolism of serotonin (5-HT). The present study examines plasma dehydroepiandrosterone-sulphate (DHEA-S) and the cortisol/DHEA-S ratio following administration of L-5-hydroxytryptophan (5-HTP), the direct precursor of 5-HT, to autistic patients. METHODS Plasma DHEA-S levels were determined both before and after administration of 5-HTP or placebo, on two consecutive days in a single blind order in 18 male autistic patients and 22 matched healthy controls. RESULTS The 5-HTP-induced DHEA-S responses were significantly higher in autistic patients than in controls. In baseline conditions, the cortisol/DHEA-S ratio was significantly higher in autistic patients than in controls. DISCUSSION The results suggest that autism is accompanied by a major disequilibrium in the serotonergic system. The increased Cortisol (neurotoxic) versus DHEA-S (neuroprotective) ratio suggests that an increased neurotoxic potential occurs in autism.

5-Hydroxytryptophan (5-HTP) is the intermediate metabolite produced when the body initiates the process of converting the essential amino acid L-tryptophan to serotonin. Serotonin levels in the body are associated with the regulation of sleep, mood, aggression, appetite, temperature, sexual behavior, and pain sensation. Supplementing with 5-HTP to facilitate serotonin production is preferable to supplementing with L-tryptophan because, unlike L-tryptophan, 5-HTP cannot be shunted into niacin or protein production. Supplementation with 5-HTP bypasses the conversion of L-tryptophan into 5-HTP by the enzyme tryptophan hydroxylase, the rate-limiting step in the synthesis of serotonin and a step that can be inhibited by a number of factors, including stress, insulin resistance, increasing age, and deficiencies of vitamin C, folate, and iron. 5-HTP is well absorbed when taken orally, with about 70 percent ending up in the bloodstream. Intestinal absorption of 5-HTP does not require the presence of a

5-Hydroxytryptophan (5-HTP) is the intermediate metabolite the body produces when it initiates the process of converting the essential amino acid L-tryptophan to serotonin. Therefore, supplementation with 5-HTP will bypass the conversion of L-tryptophan into 5-HTP by the enzyme tryptophan hydroxylase - which is the rate-limiting step in the synthesis of serotonin - and is a conversion that can be inhibited by a number of factors, including stress, insulin resistance, increasing age, and deficiencies of vitamin C, folate, and iron.* 5-HTP is well absorbed when taken orally, with about 70 percent going into the bloodstream.* Intestinal absorption of 5-HTP does not require the presence of a transport molecule, and its absorption is not affected by the presence of other amino acids; therefore, 5-HTP can be taken with meals without reducing its effectiveness. 5-HTP has been shown to have a beneficial impact on mood, sleep, carbohydrate cravings, and discomfort associated with fatigue.* Numerous ...

5-hydroxytryptophan (5-htp) with Vitamin B6 supports serotonin production. Pharmaceutical Grade Anti-Anxiety Formula for Anxiety, Stress, depression

and United States 5 Hydroxytryptophan 5 HTP Industry Latest Research Report. Complete Market Research, Market Analysis, CAGR, Trends, Major Players, Market Share, Market Size, Forecast.

Learn more about 5-Hydroxytryptophan at LewisGale Regional Health System Supplement Forms/Alternate Names 5-HTP Uses Principal Proposed Uses ...

Cavalli, sforza L.; Santachiara, S A.; Wang, L; Erdelyi, E; and Barchas, J, Electrophoretic study of 5-hydroxytryptophan decarboxylase from brain and liver in several species. (1974). Subject Strain Bibliography 1974. 607 ...

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5-HTP L-5-hydroxytryptophan * Supports Normal Sleep Cycles * 100 mg 5-HTP (L-5-Hydroxytryptophan) is an intermediate in the natural conversion of the essential amino acid, tryptophan, to serotonin. Clinical studies have shown that 5-HTP increases the amount and availability of serotonin produced by the body. Increased brain serotonin levels may produce positive effects on emotional well-being, appetite regulation, melatonin production and maintaining a healthy sleep cycle. Source Naturals 5-HTP is naturally derived from the seeds of the African plant Griffonia simplicifolia. Supplement Facts for 100 mg Capsule Serving Size: 1 capsule(s) Amount Per Serving - % Daily Value 5-HTP (from Griffonia simplicifolia) 100 mg Other Ingredients: microcrystalline cellulose, gelatin (capsule), colloidal silicon dioxide, and magnesium stearate. Warning: In some people, nausea, headaches, nasal congestion, or constipation may occur. If these symptoms occur, lower the dose, or spread the dose

Five (5)-HTP 5-Hydroxytryptophan Supports Serotonin Synthesis* Five (5)-HTP Highlights 5-Hydroxytryptophan Capsules May Be Useful In Promoting Mental Health As

Save 52% Lindberg - 5-HTP 100 mg 60 Capsules 5-HTP 100 mg 5-Hydroxytryptophan Serotonin Precursor For Mood Support and Appetite Control* 5-HTP is a precursor of serotonin, one of the most important neurotransmitters in the brain.* It provides support for many brain functions, including mood, appetite control and sleep patterns.*

5-hydroxytryptophan is a natural amino acid that serves as a precursor to serotonin, the brains feel good neurotransmitter.** By supporting healthy serotonin levels in the brain, 5-HTP benefits emotional wellness in many ways.** It is most commonly used to support a bright mood, calm disposition, and positive state of mind.** In addition to elevating serotonin, 5-HTP naturally supports other neurotransmitters including dopamine, beta-endorphin and melatonin.**. A serotonergic agent, 5-hydroxytryptophan easily crosses the blood-brain barrier. In the brain, it rapidly changes into serotonin -- optimizing neural messaging where it is needed most.** By directly influencing serotonin levels in the brain, 5-HTP supports the healthy neurotransmitter signaling that is associated with emotional and cognitive health.**. ...

5-hydorxytryptophan (5-HTP) is a compound made from the amino acid (protein) tryptophan and is primarily found in the brain. 5-HTP is one of the basic building blocks for serotonin, a neurotransmitter (brain chemical) thought to be responsible for mood regulation.

Depression: Much of the published research on 5-HTP has to do with its use in the treatment of depression. Since the early 1970s, at least 15 studies have evaluated the clinical effects of 5-HTP on depression. These are summarized in. Taken together, these studies examined a total of 511 patients with different types of depression. Of these 511 subjects, 285 (56%) showed significant improvement while taking 5-HTP.. In addition, biochemical studies show 5-HTP is closely involved in depressive disorders. In a study employing positron-emission tomography (PET) scanning, eight healthy volunteers and six people diagnosed with major depression received infusions of radiolabelled 5-HTP. The researchers found significantly less 5-HTP crossed the blood-brain barrier into the brains of the depressed subjects than into the brains of the normal controls. The authors suggested the transport of 5-HTP across the blood-brain barrier may be compromised in major depression, which might make the brain dependent on ...

Interpretive Summary: Serotonin regulates maternal calcium homeostasis during the perinatal period of sheep. By: Anne Wallace. Serotonin is a neurotransmitter produced from the amino acid tryptophan, which is first converted to the intermediary molecule 5-Hydroxytryptophan (5-HTP). In this December 2019 study published in the Journal of Animal Science, researchers supplemented pregnant sheep with serotonin precursors L-Tryptophan and 5-HTP in order to evaluate how calcium homeostasis and gene expression was affected by this neurotransmitter.. Sheep infused with IV saline, saline with L-tryptophan, or saline with 5-HTP for seven days prepartum. Mammary tissue, femur tissue, postpartum milk and serum (pre- and post-partum) was collected and analyzed. The 5-HTP infusions increased total serum calcium and total milk calcium of sheep, compared to the control. Several transport proteins involved in calcium homeostasis e.g. the parathyroid hormone-related protein (PTHrP) sodium/calcium exchanger, were ...

Certified Gluten-Free by the Gluten-Free Certification Organization, www.gluten.org. Promotes enhanced serotonin levels. May improve emotional well-being, appetite control and sleep/wake cycles. Made with hypoallergenic, vegan ingredients. 5-HTP (5-Hydroxtryptophan) encourages increased serotonin levels in the brain to

Save 52% Fitness Labs - 5-HTP 100 mg 60 Capsules 5-HTP 100 mg Mood Support* Serotonin Precursor* For Mood, Appetite Control and Restful Sleep* 5-HTP provides natural support for a positive mood, appetite control and the regulation of sleep cycles.* 5-HTP is a precursor for the bodys production of serotonin, a major neurotransmitter of the nervous system.*

NOTE* - This product is part of the Weight Loss Package.. Appetite Curb™ contains key amino acids to support the biosynthesis of neutrotransmitters involved in appetite control, carbohydrate or fat cravings, and mood. Chromium is present to support healthy glucose metabolism and support food in-take regulation.. 5-Hydroxytryptophan (5-HTP) is a naturally-occurring amino acid precursor to serotonin. Numerous studies during the 90s, including those randomized, double-blind, and placebo-controlled, confirmed the safety and efficacy of 5-HTP in reducing appetite and food intake in obese healthy and non-insulin-dependent diabetic individuals. A 2006 study in mice concluded, 5-HTP-induced anorexia may be mediated by facilitation of leptin secretion. Vitamins B6 and C are important cofactors in the 5-HTP to serotonin pathway. Among the several serotonin receptors thus identified, the 5HT2C receptors are suspected in control of food intake. Mice without this receptor exhibit increased food intake ...

A decreased degree of mind 5-hydroxytryptamine (5-HT) continues to be theorized to be always a core pathogenic element in major depression for half of a hundred years. 5-HTExt levels inside a mouse style of naturalistic 5-HT insufficiency, the tryptophan hydroxylase 2 His439 knockin (Tph2KI) mouse. With this review, we will critically measure the proof for 5-HT insufficiency in major depression and the feasible part of polymorphisms in the Tph2 gene like a causal element in 5-HT insufficiency, the latter looked into from a scientific aswell as preclinical position. [2]. Around once, reports were released indicating that the 5-HT precursor 5-hydroxytryptophan (5-HTP) acquired antidepressant results [3] 3681-93-4 supplier in human beings and increased human brain 5-HT amounts in pets [4]. Furthermore, the TCA clomipramine demonstrated equal antidepressant efficiency to various other TCAs but 3681-93-4 supplier inhibited 5-HT uptake with an increase of than 100-flip higher affinity compared to the ...

Positron emission tomography (PET) performed with various radiolabelled compounds facilitates the study of tumor biochemistry. If the tumor uptake of an administered tracer is greater than that of surrounding normal tissue, it is also possible to localize the tumor. In initial studies, 18F-labeled deoxyglucose (FDG) was attempted to visualize the tumors, since this tracer had been successfully used in oncology, reflecting increased glucose metabolism in cancerous tissue. However, this tracer was not to any significant degree taken up by the neuroendocrine tumors. Instead, the serotonin precursor 5-hydroxytryptophan (5-HTP) labeled with 11C was used and showed an increased uptake and irreversible trapping of this tracer in carcinoid tumors. The uptake was selective and the resolution so high that we could detect more liver and lymph node metastases with PET than with CT or octreotide scintigraphy. One problem was, however, the high renal excretion of the tracer producing streaky artifacts in the ...

Phytoextractum 5-HTP (100mg) - Serene Science® 5-HTP (30 Count) Balanced Mood 5-HTP (L-5-Hydroxytryptophan) is an intermediate in the natural conversion of the essential amino acid tryptophan to serotonin, a brain chemical associated with positive mood and well-being. Preclinical studies show that 5-HTP may help support healthy levels of serotonin in the body. In addition to a balanced

R. R. Brown, Y. Ozaki, S. P. Datta, et al., Implications of interferon-induced tryptophan catabolism in cancer, auto-immune diseases and AIDS. In: Kynurenine and Serotonin Pathways, R. Schwarcz, et al., (Eds.), Plenum Press, New York, 1991.. C. Cangiano, F. Ceci, M. Cairella, et al., Effects of 5-hydroxytryptophan on eating behavior and adherence to dietary prescriptions in obese adult subjects. In Kynurenine and Serotonin Pathways, R. Schwarcz, et al., (Eds.), Plenum Press, New York, 1991.. R. F. Cathcart, Vitamin C: the nontoxic, nonratelimited, antioxidant free radical scavenger. Medical Hypotheses 18: 61-7, 1985.. R. F. Cathcart, A unique function for Ascorbate. Medical Hypotheses 35: 32-7, 1991.. Robert Cathcart, M.D., personal communication, February 1992. L. M. E. Finocchiaro, E. S. Arzt, S. Fernandez-Castelo, et al., Serotonin and melatonin synthesis in peripheral blood mononuclear cells: Stimulation by interferon-gamma as part of an immunomodulatory pathway. Journal of Interferon ...

A large number of studies appear to address the research questions, but few are of sufficient quality to be reliable. Available evidence does suggest these substances are better than placebo at alleviating depression. Further studies are needed to evaluate the efficacy and safety of 5-HTP and trypto …

This invention provides methods and compositions for incorporation of an unnatural amino acid into a peptide using an orthogonal aminoacyl tRNA synthetase/tRNA pair. In particular, an orthogonal pair

5-HTP has a recommended dosage of 300-500 mg/day. Do NOT buy until you read this REAL 5-HTP Review. 5-HTP, also known as 5-Hydroxytryptophan or Oxitri

EarthTurns.com sells only American made 5-HTP supplements. We offer discount 5 HTP supplements that are shipped same day as ordered. 5 HTP is also known as 5-Hydroxytryptophan, a naturally occurring precursor to serotonin.

|p|5-HTP Extended Release by Seeking Health provides 200 mg of L-5-hydroxytryptophan, an important amino acid precursor of certain neurotransmitters. Each vegetarian tablet provides pure 5-HTP from Griffonia simplicifolia seeds. 5-HTP may help support hea

5 - HTP HTP specifications & features from suppliers/manufacturer Specifications:1) Botanical source: Griffonia simplicifolia (DC.) baillon; seeds used2) Appearance: off-white fine powder3) 5-hydroxytryptophan content: 99% (HPLC assay)4) Pharmacological actions: a) Suppresses appetite b) Enhances sleep

Douglas Labs 5-HTP 50mg 100c contains 50 mg of natural L-5-Hydroxytryptophan (5-HTP) extracted from seeds of the Griffonia plant in each vegetarian capsule. Purchase 5-HTP 50mg 100c online with free shipping!

Serotonin is an important neurotransmitter that influences mood, appetite, sleep habits, and pain tolerance. Although serotonin is made by the body, the building blocks it needs are often lacking. 5-HTP from Natural Factors is a free-form amino acid and a direct precursor to serotonin.. By increasing serotonin levels, 5-HTP helps promote healthy mood balance and is useful as a sleep aid for people who have difficulty sleeping. It also helps relieve symptoms of fibromyalgia and can be used preventatively to help reduce the severity and duration of migraine headaches.. 5-HTP is sourced naturally from the seeds of the African plant Griffonia simplicifolia The timed-release caplets are designed to release 5-HTP gradually to minimize the mild gastrointestinal side effects sometimes caused by 5-HTP. Each caplet contains 100 mg of 5-HTP to increase serotonin levels without creating dependence. It is guaranteed pure and free from contaminants, contains no GMOs, and is suitable for vegetarians and ...

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In the human body 5-HTP (5-hydroxytryptophan) is a precursor to the neurotransmitter serotonin. Serotonin is found in the brain‚ blood platelets and cells of the gastrointestinal tract. Since serotonin is found in the brain and central nervous system‚ it has many implications in cognition‚ mental health and sleep patterns. Supplementation of 5-HTP has shown an ability to increase serotonin levels and consequently support healthy sleep patterns‚ improve mood and improves outcomes for weight management.. These statements have not been evaluated by the Food and Drug Administration (FDA). These products are not meant to diagnose‚ treat or cure any disease or medical condition. Please consult your doctor before starting any exercise or nutritional supplement program or before using these or any product during pregnancy or if you have a serious medical condition. ...

may be looking for a drug-free alternative to help combat stress and brighten their mood.. Natrol 5-HTP Fast Dissolve is a drug-free, plant-derived mood enhancement supplement that promotes calmness throughout the body by increasing serotonin levels. Serotonin is the chemical messenger that affects emotions, mood and behavior.. Stress and anxiety are two primary serotonin disruptors. They can interrupt the bodys normal production of serotonin which can result in a negative mood change. To combat this, the body converts a naturally occurring amino acid called 5-HTP (5-hydroxytryptophan) into serotonin to help balance mood levels, but on some days the body might need extra support from a supplement. Natrol 5-HTP works within the brain and the central nervous system to help balance serotonin levels that affect mood.. Natrol 5-HTP is designed to help consumers live a more balanced lifestyle when life gets hectic. 5-HTP is a great tool to help calm stress and anxiety during the holidays, said ...

Source Naturals Serene Science 5-HTP 50 mg 60 capsule -HTP (L-5-Hydroxytryptophan) is an intermediate in the natural conversion of the essential amino aci...

This page provides useful content and local businesses that can help with your search for 5-HTP Supplements. You will find helpful, informative articles about 5-HTP Supplements, including Improve Your Mood with 5-HTP Supplements. You will also find local businesses that provide the products or services that you are looking for. Please scroll down to find the local resources in Frankfort, KY that will answer all of your questions about 5-HTP Supplements.

The dispute, which is better with supplements, has been going on for some time. Some users say that 5-HTP guarantees better results in terms of improving mood. Others, however, believe that L-tryptophan has a stronger effect on sleep regulation. Below are a few facts in that matter.. One of the things to consider when deciding L-Tryptophan or 5-HTP supplementation is that 5-HTP is so effective that your body can start to build tolerance after some time. This has not yet been proven by researchers, but theoretically can occur after long-term use of 5-HTP. L-tryptophan on the other hand, although more subtle in its effects, may be safer and healthier for long-term use. L-tryptophan supplements are also less likely to interact with drugs than 5-HTP.. ...

What is 5-HTP? 5-HTP (5-hydroxytryptophan) is a naturally occurring amino acid in the body and the intermediate precursor in the biosynthesis of serotonin. Serotonin acts as a neurotransmitter, which can affect mood, sleep and appetite.* As a supplement, 5-HTP comes from the seeds of the African plant Griffonia simplicifolia. Why take Vitamistic 5-HTP? Vitamistic 5-HTP [More] ...