Dr. Marc Garnick discusses prostate cancer chemoprevention with the use of the 5 Alpha Reductase inhibitors finasteride and dutasteride.
Anti-androgen can be used in the treatment of benign prostatic hyperplasia, acne, hirsutism, and androgenic alopecia. For the search of anti-androgenic activity through steroid 5-alpha reductase...
Saw palmetto extract (SPE), used widely for the treatment of benign prostatic hyperplasia (BPH) has been shown to bind alpha(1)-adrenergic, muscarinic and 1,4-dihydropyridine (1,4-DHP) calcium channel antagonist receptors. Major constituents of SPE are lauric acid, oleic acid, myristic acid, palmiti …
ABSTRACTIntroductionBenign prostatic hyperplasia (BPH) is a common problem affecting middle-aged and elderly men. First-line medical therapy includes α 1blockers and 5α-reductase inhibitors (5ARIs), such as finasteride and dutasteride. 5ARI use has been associated with adverse sexual outcomes, inclu
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12-O-Methylcarnosic acid (12-Methoxycarnosic acid), a diterpene carnosic acid isolated from the acetone extract of Salvia microphylla, is an active constituent of 5α-reductase inhibition with an IC50 value of 61.7 μM. 12-O-Methylcarnosic acid inhibits proliferation in LNCaP cells. 12-O-Methylcarnosic acid has antioxidant, anti-cancer and antimicrobial activity. - Mechanism of Action & Protocol.
Antonio L. PASTORE 1, 2 ✉, Andrea FUSCHI 1, 2, Cosimo DE NUNZIO 3, Matteo BALZARRO 4, Yazan AL SALHI 1, 2, Gennaro VELOTTI 1, 2, Alessia MARTOCCIA 1, 2, Lorenzo CAPONE 1, 2, Nelia AMIGONI 4, Mario FALSAPERLA 5, Consalvo MATTIA 6, Walter ARTIBANI 4, Andrea TUBARO 3, Antonio CARBONE 1, 2. 1 Urology Unit, Department of Medico- Surgical Sciences and Biotechnologies, Faculty of Pharmacy and Medicine, Sapienza University of Rome, Latina, Italy; 2 Uroresearch, no profit Association for Research in Urology, Latina, Italy; 3 Department of Urology, SantAndrea Hospital Rome, Sapienza University of Rome, Rome, Italy; 4 Department of Urology, Azienda Ospedaliera Universitaria Integrata, University of Verona, Verona, Italy; 5 Department of Urology, Vittorio Emanuele Hospital, Catania Italy; 6 Anesthesiology Unit, Department of Medico-Surgical Sciences and Biotechnologies, Faculty of Pharmacy and Medicine, Sapienza University of Rome, Latina, Italy. ...
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Warnings about systemic 5 Alpha Reductase Inhibitors.. Im 36 years old and have been taking finasteride (varying doses) and minoxidil to treat my diffuse hairloss for about 5 years. I regrew some hair and have managed to keep it status quo, up to this date. Im writing my story to make others aware of what systemic 5-ar inhibitors may do to their long term health. The recent release of a more potent DHT inhibitor, dutasteride, has me even more concerned.. A little over 3 years after starting finasteride my eyes became quite dry and very red. Ive seen a number of ophthalmologists regarding my dry eye condition and had to have punctal plugs inserted into the 4 drainage ducts (located at the inside corner of the eye) to conserve my tears. About 5 months ago I reduced my finasteride dose to 0.5 mg/day from 2.5 mg/day with no improvement obtained.. Research I have done clearly shows both the lacrimal (aqueous tear producing) and meibomian (produce oil) glands in the eye are under androgen control. ...
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Clinical Trials - clinicaltrials.gov The enzyme 5-alpha reductase is present in small amounts in muscle and converts testosterone to dihydrotestosterone (DHT). ...
CO Finasteride: Finasteride belongs to a group of medications known as 5-alpha-reductase inhibitors. Finasteride is used to treat benign prostatic hyperplasia (BPH), also known as enlarged prostate. Finasteride can be used alone or in combination with another medication called doxazosin (an alpha blocker). These medications may be taken together to reduce the progress of your BPH symptoms. If you are taking this combination, be sure to also read the patient information for doxazosin.
Finasteride is an FDA-approved hair loss drug that works by blocking an enzyme that would otherwise change testosterone to DHT. It has to be taken every day and may take at least three months to take effect. It can have some side effects, including sexual problems, and its worth noting that if a man stops taking finasteride, the hair he grew back will probably be lost.. Finasteride comes as a tablet to take by mouth. It is usually taken once a day with or without food. Take finasteride at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take finasteride exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.. If you are taking finasteride to treat BPH, you should know that finasteride may control your condition, but will not cure it. It may take at least 6 months before your symptoms improve. Continue to take finasteride even ...
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Most common lower urinary tract symptoms in post-middle aged males are due to benign prostate enlargement. Pharmacological treatments include *alpha blockers and 5-alpha reductase inhibitors (5ARIs). 5ARIs have been shown to reduce the size of the prostate gland. 5ARIs block the transformation of testosterone into dehyrotestosterone, an attempt to prevent division of the cells in […]. View Post ...
Finasteride, a 5 alpha-reductase inhibitor, decreases prostate size and improves symptoms in men with benign prostatic hyperplasia. However, little is known about prostate histopathology in men taking finasteride. To determine the mechanism by which
B. Chronic administration (defined as daily or every other day for continued use greater than 14 days) of corticosteroids deemed systemic by investigator within 28 days before the first planned dose of PSA-TRICOM. Use of inhaled steroids, nasal sprays, and topical creams for small body areas is allowed.. C. Serious intercurrent medical illness that, in the judgment of the investigator, would interfere with patient s ability to carry out the treatment program.. D. History of seizure, including any febrile seizure, loss of consciousness, or transient ischemic attack, or any condition that may pre-dispose to seizure (e.g., prior stroke, brain arteriovenous malformation, head trauma with loss of consciousness requiring hospitalization).. E. Other medications used for urinary symptoms including 5-alpha reductase inhibitors (finasteride and dutasteride) and alternative medications known to alter PSA (eg phytoestrogens and saw palmetto). F. History of prior chemotherapy. G. History of prior ...
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FDA Q&A: 5-alpha reductase inhibitors (5-ARIs) may increase the risk of a more serious form of prostate cancer https://t.co/laGKBe1wo0 06:11:11 PM September 04, 2017 ReplyRetweetFavorite ...
Alopecia is a common condition that can be treated by using drugs belonging to classes like 5-alpha reductase inhibitors, androgen independent hair growth stimulator,androgen receptor inhibitor, antihistamine, corticosteroids, anti-psorioatic agent, antibiotic and topical immunotherapy. Read on to know more.
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