This longitudinal study in a real-world COPD population that carefully minimized misclassification of exacerbations and the influence of confounding did not show an association of 25-hydroxyvitamin D with exacerbations and mortality.

3-epi-25-Hydroxyvitamin D3 (6,19,19-d3) ≥98 atom % D, ≥98% (CP); find Sigma-Aldrich-751316 MSDS, related peer-reviewed papers, technical documents, similar products & more at Sigma-Aldrich

Easy to read patient leaflet for Drisdol (Ergocalciferol Capsules). Includes indications, proper use, special instructions, precautions, and possible side effects.

Salim, A, Lanham-New, SA and Hakim, OA (2012) Serum 25-Hydroxyvitamin D concentrations in relation to dietary fat intake and body fat concentration in Caucasian and Asian women ...

Previously reported associations between vitamin D status, as measured by serum 25-hydroxyvitamin D [25(OH)D] concentrations, and cardiometabolic risk factors were largely limited by variability in 25(OH)D assay performance. In accordance with the Vitamin D Standardization Program, serum 25(OH)D measurement was recently standardized in the National Health and Nutrition Examination Survey (NHANES) to reduce laboratory and method related differences in serum 25(OH)D results. We evaluated the overall and ethnic-specific associations between the newly standardized serum 25(OH)D concentrations and cardiometabolic risk in U.S. adults. This study examined standardized 25(OH)D data from five cycles of the NHANES (2001-2010). The total sample included 7674 participants (1794 Mexican-Americans, 4289 non-Hispanic whites, and 1591 non-Hispanic blacks) aged ≥ 20 years who were examined in the morning after overnight fasting. Serum 25(OH)D was directly measured by liquid chromatography-tandem mass spectrometry (LC

Background Previously reported associations between vitamin D status, as measured by serum 25-hydroxyvitamin D [25(OH)D] concentrations, and cardiometabolic risk factors were largely limited by...

In this large cohort study, serum 25(OH)D concentrations were inversely associated with all-cause and cause-specific mortality. In particular, vitamin D deficiency [25(OH)D concentration |30 nmol/L] was strongly associated with mortality from all causes, cardiovascular diseases, cancer, and respi …

Ergocalciferol is given orally. Ergocalciferol is a form of prehormone which later converted into calcitriol and calcifediol. Calcifediol and calcitriol will increase the absorption of calcium and phosphate from intestine which increase the serum level of

Prevalence of cardiovascular risk factors and the serum levels of 25-hydroxyvitamin D in the United States: data from the Third National Health and Nutrition Examination Survey.

Data Sources: A systematic review of English and non-English articles using MEDLINE and the Cochrane Controlled Trials Register (1960-2005), and EMBASE (1991-2005). Additional studies were identified by contacting clinical experts and searching bibliographies and abstracts presented at the American Society for Bone and Mineral Research (1995-2004). Search terms included randomized controlled trial (RCT), controlled clinical trial, random allocation, double-blind method, cholecalciferol, ergocalciferol, 25-hydroxyvitamin D, fractures, humans, elderly, falls, and bone density ...

Despite advances in prevention, screening, early detection, and treatment, colorectal cancer (CRC) remains the 3rd most commonly diagnosed cancer and the 2nd le...

Get Sample PDF of report at @ http://www.360marketupdates.com/enquiry/request-sample/10321415 After the basic information, the report sheds light on the production. Production plants, their capacities, global production and revenue are studied. Also, the Olestra Market growth in various regions and R&D status are also covered.. Further in the report, the Olestra Market is examined for price, cost and gross. These three points are analysed for types, companies and regions. In continuation with this data sale price is for various types, applications and region is also included. The Olestra Industry consumption for major regions is given. Additionally, type wise and application wise consumption figures are also given.. Analysis also include consumption. Import and export data for Regions North America, Europe, China, Japan, Southeast Asia, India.. Purchase this report @ http://www.360marketupdates.com/purchase/10321415 With the help of supply and consumption data, gap between these two is also ...

Context Lower serum 25-hydroxyvitamin D concentrations are associated with greater risks of many chronic diseases across large, prospective community-based studies. Substrate 25-hydroxyvitamin D must be converted to 1,25-dihydroxyvitamin D for full biological activity, and complex metabolic pathways suggest that interindividual variability in vitamin D metabolism may alter the clinical consequences of measured serum 25-hydroxyvitamin D.. Objective To investigate whether common variation within genes encoding the vitamin D-binding protein, megalin, cubilin, CYP27B1, CYP24A1, and the vitamin D receptor (VDR) modify associations of low 25-hydroxyvitamin D with major clinical outcomes.. Design, Setting, and Participants Examination of 141 single-nucleotide polymorphisms in a discovery cohort of 1514 white participants (who were recruited from 4 US regions) from the community-based Cardiovascular Health Study. Participants had serum 25-hydroxyvitamin D measurements in 1992-1993 and were followed up ...

Introduction: Vitamin D deficiency is still a common serious health problem among women of reproductive age and their infants in developing countries at the outset of the third millennium. Information on vitamin D status of urban lactating women in Islam Abad Gharb is not available, but it seems that, as in other physiologic groups in other areas of Iran, vitamin D deficiency may be common there, too. The aims of this study were: 1) To determine the serum 25-hydroxyvitamin D concentration and its association with independent variables (age, occupation, family size), and 2) To determine the vitamin D status of urban lactating women and its association with the independent variables. Materials & Method: In this descriptive analytical cross-sectional study, using a simple randomized sampling technique, a total of 155 lactating women, whose babies were less than 12 months, were selected from 8 urban health centers in Islam Abad Gharb in winter 2004. A general questionnaire was completed to obtain ...

The present study is one of the few studies investigating vitamin D status in the pediatric population in the southern region of the United States. In particular, this study is the first to address 25-hydroxyvitamin D levels over 4 seasons in a cohort of black and white adolescents living at southern US latitudes. Our data demonstrate that low vitamin D status is common among adolescents residing in the southeastern region and is related to various adiposity and lifestyle factors.. From NHANES III (1988-1994)2 to NHANES 2000-2004,2,24 the prevalence of vitamin D deficiency (25-hydroxyvitamin D levels of ≤50 nmol/L) in black and white adolescents increased from 28% to 48% and that of vitamin D insufficiency (25-hydroxyvitamin D levels of ≤75 nmol/L) increased from 66% to 81%. More importantly, ∼70% of the black adolescents in NHANES 2000-2004 had winter serum vitamin D deficiency, which might have important implications for known health disparities.24 The NHANES provided key information ...

Vitamin D is crucial for maintenance of musculoskeletal health, and might also have a role in extraskeletal tissues. Determinants of circulating 25-hydroxyvitamin D concentrations include sun exposure and diet, but high heritability suggests that genetic factors could also play a part. We aimed to identify common genetic variants affecting vitamin D concentrations and risk of insufficiency.We undertook a genome-wide association study of 25-hydroxyvitamin D concentrations in 33 996 individuals of European descent from 15 cohorts. Five epidemiological cohorts were designated as discovery cohorts (n=16 125), five as in-silico replication cohorts (n=9367), and five as de-novo replication cohorts (n=8504). 25-hydroxyvitamin D concentrations were measured by radioimmunoassay, chemiluminescent assay, ELISA, or mass spectrometry. Vitamin D insufficiency was defined as concentrations lower than 75 nmol/L or 50 nmol/L. We combined results of genome-wide analyses across cohorts using Z-score-weighted meta-analysis

Evidence associating serum 25-hydroxyvitamin D (25(OH)D) concentrations and cardiometabolic risk factors is inconsistent and studies have largely been conducted in adult populations. We examined the prospective associations between serum 25(OH)D concentrations and cardiometabolic risk factors from adolescence to young adulthood in the West Australian Pregnancy Cohort (Raine) Study. Serum 25(OH)D concentrations, BMI, homoeostasis model assessment for insulin resistance (HOMA-IR), TAG, HDL-cholesterol and systolic blood pressure (SBP) were measured at the 17-year (n 1015) and 20-year (n 1117) follow-ups. Hierarchical linear mixed models with maximum likelihood estimation were used to investigate associations between serum 25(OH)D concentrations and cardiometabolic risk factors, accounting for potential confounders. In males and females, respectively, mean serum 25(OH)D concentrations were 73·6 (sd 28·2) and 75·4 (sd 25·9) nmol/l at 17 years and 70·0 (sd 24·2) and 74·3 (sd 26·2) nmol/l at ...

Hypovitaminosis D and stress are common problems among the elderly. The aim of this cross-sectional nationally representative study was to evaluate the association between hypovitaminosis D and stress perception using large-scale nationally representative data from the Korea National Health and Nutrition Examination Survey (2012-2013). In our study, a total of 1393 elders (≥65 years old) were included to evaluate the association between hypovitaminosis D and stress perception. Serum 25-hydroxyvitamin D levels were determined using radioimmunoassay, and perceived stress status was assessed by a self-reporting questionnaire. The association between hypovitaminosis D and stress perception according to sex was examined using logistic regression analysis. After multivariate adjustment for sociodemographic and lifestyle factors and comorbidities, hypovitaminosis D was significantly associated with perceived stress (odds ratio, 2.73; 95% confidence interval, 1.10-6.77; p = 0.029) among women; however, this

Data Advisory. The purpose of this analytical note is to inform researchers that serum 25-hydroxyvitamin D (25(OH)D) data from NHANES III (1988-1994) and NHANES 2001-2006 have been converted by using regression to equivalent 25(OH)D measurements from a standardized liquid chromatography-tandem mass spectrometry (LC-MS/MS) method. The LC-MS/MS method was used in the analysis of the newly released NHANES 2007-2010 25(OH)D data. This standardization was done so that researchers could use 25(OH)D data that are equivalent to 25(OH)D measurements assayed with a LC-MS/MS method that is traceable to the NIST reference materials. The LC-MS/MS-equivalent data for NHANES III (1988-1994) and NHANES 2001-2006 are needed to compare with 25(OH)D data from NHANES 2007-2010, which were obtained using the LC-MS/MS method. This analytical note replaces the previous analytical note entitled Revised Analytical Note for NHANES 2000-2006 and NHANES III (1988-1994) 25-Hydroxyvitamin D Analysis (Revised November ...

Project III: Vitamin D Concentrations, Genetic Modifiers, and Parkinson Disease Parkinson disease (PD) results from genetic and environmental factors and comple...

Vitamin D in the diet program or pores and skin synthesis is biologically inactive; enzymatic conversion (hydroxylation) while in the liver and kidney is necessary for activation. As vitamin D can be synthesized in suitable amounts by most mammals subjected to adequate daylight, It is far from A vital dietary element, and so not technically a vitamin.[three] Alternatively it may be regarded as a hormone, with activation from the vitamin D Professional-hormone causing the active kind, calcitriol, which then creates consequences through a nuclear receptor in numerous unique places.[3] Cholecalciferol is transformed within the liver to calcifediol (twenty five-hydroxycholecalciferol); ergocalciferol is transformed to 25-hydroxyergocalciferol ...

AbstractBackground Poor vitamin D status (i.e. low serum 25-hydroxyvitamin D (25(OH)D)) has been associated with adverse clinical outcomes during pregnancy and childhood. However, the interpretation of serum 25(OH)D levels may be complicated by the presence of the C3-epimer of 25(OH)D. We aimed to quantify C3-epi-25(OH)D3 in pregnant women and fetuses, to explore the relationship of the C3-epimer between maternal and cord samples, and to establish whether infant C3-epimer abundance is explained by prenatal formation. Methods In a sub-study of a randomized trial of prenatal vitamin D3, 25(OH)D3 and C3-epi-25(OH)D3 were quantified by LC-MS/MS in 71 sets of mother-fetus-infant serum samples, including maternal delivery specimens, cord blood, and infant specimens acquired at 3-28 weeks of age. Results Without supplementation, median concentrations of C3-epi-25(OH)D3 were higher in infants (6.80 nmol/L) than mothers (0.45 nmol/L) and cord blood (0 nmol/L). However, there was substantial variation such that

25-Hydroxyvitamin D3 Levels, BsmI Polymorphism and Insulin Resistance in Brazilian Amazonian Children. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.

Recent evidence shows that low vitamin D status is related to higher risks for hypertension, dyslipidemia, diabetes, obesity, metabolic syndrome (MS), and cardiovascular (CVD) events. Some studies support the association between higher levels of vitamin D and a lower prevalence of cardiometabolic disease, however, this conclusion is not consistent in literature. PURPOSE: To investigate the associations of serum 25-hydroxyvitamin D (25(OH)D) concentration and clustering of risk factors for cardiometabolic disorders. METHODS: A total of 508 men and women (aged 19 to 70 years) from urban areas of Shanghai, China, were investigated. Demographic and anthropometric data were collected, and fasting blood samples were assessed for serum 25(OH)D, blood glucose and lipid concentrations. Participants were statistically grouped into tertiles according to their serum concentration level. Across the tertiles, linear regression analyses were used to evaluate associations between serum 25(OH)D concentration and

Sufficient vitamin D status may be defined as the evolutionary established circulating 25-hydroxyvitamin D [25(OH)D] matching our Paleolithic genome. We studied serum 25(OH)D [defined as 25(OH)D2 + 25

Causes of MS: It is not right to think vitamin D deficiency causes MS, but it seems a healthy level of vitamin D helps to prevent symptoms of MS in some people. There are several reports about this, some clinical trials are in progress. Corticosteroid medicine is often used temporarily to stop relapses of MS. Its effects on vitamin D are not relevant, the benefits of using it for a short time are better. ...Read more See 3 more doctor answers ...

Iranian Journal of Diabetes and Obesity is scientific quarterly journal published by Shahid Sadoughi University of Medical Sciences

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies. ...

We spotlight the scientific and medical implications of relying on serum 25D concentrations calculated by uncertified laboratories

For cancer patients, increased levels of circulating 25-hydroxyvitamin D (25[OH]D) at or near the time of diagnosis are associated with improved outcomes, according to a review.

or =100 nmol/l). There was an interaction between 25(OH)D concentration and gender in relation to CWP (interaction, p = 0.006), which was not fully explained by differences in lifestyle or social factors (adjusted interaction, p = 0.03). For women, the association between 25(OH)D concentration and CWP persisted after full adjustment (odds ratio (OR) for ...

Recent findings suggest that maternal vitamin D insufficiency during pregnancy has consequences for the offsprings bone health in later life. To investigate whether maternal vitamin D insufficiency affects fetal femur growth in ways similar to those seen in childhood rickets and study the timing during gestation of any effect of maternal vitamin D status, we studied 424 pregnant women within a prospective longitudinal study of maternal nutrition and lifestyle before and during pregnancy (Southampton Womens Survey). Using high-resolution 3D ultrasound, we measured fetal femur length and distal metaphyseal cross-sectional area, together with the ratio of femoral metaphyseal cross-sectional area to femur length (femoral splaying index). Lower maternal 25-hydroxyvitamin vitamin D concentration was not related to fetal femur length but was associated with greater femoral metaphyseal cross-sectional area and a higher femoral splaying index at 19 weeks gestation [r = -0.16, 95% confidence interval (CI) -0

TY - JOUR. T1 - Calcium absorption varies within the reference range for serum 25-hydroxyvitamin d. AU - Heaney, Robert P.. AU - Dowell, M. Susan. AU - Hale, Cecilia A.. AU - Bendich, Adrianne. PY - 2003/4/1. Y1 - 2003/4/1. N2 - Background: Calcium absorption is generally considered to be impaired under conditions of vitamin D deficiency, but the vitamin D status that fully normalizes absorption is not known for humans. Objective: To quantify calcium absorption at two levels of vitamin D repletion, using pharmacokinetic methods and commercially 1marketed calcium supplements. Design: Two experiments performed in the spring of the year, one year apart. In the first, in which participants were pretreated with 25-hydroxyvitamin D (25OHD), mean serum 25OHD concentration was 86.5 nmol/L; and in the other, with no pretreatment, mean serum concentration was 50.2 nmol/L. Participants received 500 mg oral calcium loads as a part of a standard low calcium breakfast. A low calcium lunch was provided at ...

TY - JOUR. T1 - Serum vitamin D concentrations and unexplained elevation in ALT among US adults. AU - Liangpunsakul, Suthat. AU - Chalasani, Naga. PY - 2011/7. Y1 - 2011/7. N2 - Background: Low serum levels of vitamin D are associated with metabolic syndrome. Participants in NHANES III with unexplained elevation in ALT levels have high prevalence of metabolic syndrome. We hypothesized that the serum concentrations of vitamin D were inversely associated with unexplained elevation in ALT. Methods: A total of 6,826 fasting subjects underwent morning physical examination and met the inclusion and exclusion criteria. From these participants, we have constructed cases with unexplained elevation in ALT (n = 308) and compared their serum vitamin D concentrations to matched controls with normal ALT (N = 979). We examined the prevalence of unexplained elevation in ALT level across different quartiles of vitamin D levels. Results: Participants with unexplained elevation in ALT had significantly lower serum ...

The 25-hydroxyvitamin D3 (25-OH-D3) is a nontoxic and low-affinity vitamin D receptor (VDR)-binding metabolic precursor of 1,25-dihydroxyvitamin D3 [1,25(OH)2D3]. We hypothesized that covalent attachment of a 25-OH-D3 analog to the hormone-binding pocket of VDR might convert the latter into transcriptionally active holo-form, making 25-OH-D3 biologically active. Furthermore, it might be possible to translate the nontoxic nature of 25-OH-D3 into its analog. We showed earlier that 25-hydroxyvitamin D3-3bromoacetate (25-OH-D3-3-BE) alkylated the hormonebinding pocket of VDR. In this communication we describe that 10 6 mol/L of 25-OH-D3-3-BE inhibited the growth of keratinocytes, LNCaP, and LAPC-4 androgen-sensitive and PC-3 and DU145 androgen-refractory prostate cancer cells, and PZ-HPV-7 immortalized normal prostate cells with similar or stronger efficacy as 1,25(OH)2D3. But its effect was strongest in LNCaP, PC-3, LAPC-4, and DU145 cells. Furthermore, 25-OH-D3-3-BE was toxic to these prostate cancer

TY - JOUR. T1 - 25-Hydroxyvitamin D, parathyroid hormone, and mortality in black and white older adults. T2 - The health ABC study. AU - Kritchevsky, Stephen B.. AU - Tooze, Janet A.. AU - Neiberg, Rebecca H.. AU - Schwartz, Gary G.. AU - Hausman, Dorothy B.. AU - Johnson, Mary Ann. AU - Bauer, Douglas C.. AU - Cauley, Jane A.. AU - Shea, M. Kyla. AU - Cawthon, Peggy M.. AU - Harris, Tamara B.. AU - Rubin, Susan M.. AU - Tylavsky, Francis A.. AU - Houston, Denise K.. PY - 2012/11. Y1 - 2012/11. N2 - Context: Previous 25-hydroxyvitamin D [25(OH)D] and mortality studies have included mostly individuals of European descent. Whether the relationship is similar in Blacks and to what extent differences in 25(OH)D explain racial disparities in mortality is unclear. Objective: The objective of the study was to examine the relationship between 25(OH)D, PTH, and mortality in Black and white community-dwelling older adults over 8.5 yr of follow-up. Design and Setting: Health ABC is a prospective cohort ...

Data Synthesis:. 13 observational studies (14 cohorts) and 18 trials were eligible. Three of 6 analyses (from 4 different cohorts) reported a lower incident diabetes risk in the highest versus the lowest vitamin D status groups. Eight trials found no effect of vitamin D supplementation on glycemia or incident diabetes. In meta-analysis of 3 cohorts, lower 25-hydroxyvitamin D concentration was associated with incident hypertension (relative risk, 1.8 [95% CI, 1.3 to 2.4]). In meta-analyses of 10 trials, supplementation nonsignificantly reduced systolic blood pressure (weighted mean difference, âˆ1.9 mm Hg [CI, âˆ4.2 to 0.4 mm Hg]) and did not affect diastolic blood pressure (weighted mean difference, âˆ0.1 mm Hg [CI, âˆ0.7 to 0.5 mm Hg]). Lower 25-hydroxyvitamin D concentration was associated with incident cardiovascular disease in 5 of 7 analyses (6 cohorts). Four trials found no effect of supplementation on cardiovascular outcomes. ...

If the health benefits of high vitamin D concentrations shown by data from observational studies are not reproduced in randomized trials … then the relation between vitamin D status and disorders are probably the result of confounding or physiological events involved in these disorders, stated lead author Professor Philippe Autier from the International Prevention Research Institute in Lyon, France.. They found that the benefits of high vitamin D concentrations from observational studies - including reduced risk of cardiovascular events (up to 58%), diabetes (up to 38%), and colorectal cancer (up to 34%) - were not confirmed in randomized trials. According to Autier, What this discrepancy suggests is that decreases in vitamin D levels are a marker of deteriorating health. Ageing and inflammatory processes involved in disease occurrence and clinical course reduce vitamin D concentrations, which would explain why vitamin D deficiency is reported in a wide range of disorders.. This systematic ...

The aim of this study was to investigate the effect of consumption of vitamin D3 versus 25-hydroxyvitamin D3 biofortified eggs on winter serum 25(OH)D in adults using a 8-wk randomized controlled trial. This research will provide new data on the potential of vitamin D enriched eggs as a food-based strategy for prevention of vitamin D deficiency ...

The Womens Health Dietetic Practice Group addresses health and nutrition issues relative to the life stages that are unique to women including preconception, prenatal, postpartum, lactation and menopause.

To the Editor: We read with interest the articles by Dr. Braun-Moscovici, et al 1 and Vacca, et al 2 reporting a strikingly high prevalence of 25-hydroxyvitamin D (25OHD) deficiency in patients with systemic sclerosis (SSc). Their remarkable findings confirm the results of our work, to our knowledge the first controlled study to demonstrate an increased prevalence of hypovitaminosis D in SSc3. The renewed interest in vitamin D in autoimmune diseases gives us the opportunity to show previously unpublished data and make some observations about this issue. Our study comprised 60 patients and 60 matched controls3. 25OHD levels were lower in patients than in controls [median 23 ng/ml (range 3-92) and 39 ng/ml (14-138), respectively; p | 0.001] even after matching for season of sampling. Thirty-eight patients had 25OHD levels below 30 ng/ml; 4 patients fell in the severe deficit range (| 10 ng/ml), 17 in the insufficiency range (≥ 10 and | 20 ng/ml), and 17 in the mild hypovitaminosis range (≥ 20 and |

Blood levels of 25-hydroxyvitamin D are used as the primary indicator of vitamin D adequacy. Within the study sample of U.S. adults, a large fraction of younger and older adults were below a suggested desirable serum vitamin D concentration of at least 75 nanomoles-per-liter (nmol/L).. The study supports the idea that correcting inadequate blood levels of vitamin D is more important than increasing dietary calcium intake beyond 566 mg a day among women and 626 mg a day among men for better bone mineral density. For example, a higher calcium intake beyond 566 mg a day may only be important among women whose vitamin D concentrations are low (less than 50 nmol/L), according to authors. Details of this study can be found in the publication Journal of Bone and Mineral Research. ...

The ergocalciferol in the Formula js may make abusers sick inside when the dosage in fact increased, however. Un patient a cesse croissant de prendre des steroides en aerosol, mais en a continue a le prendre du ergocalciferol et grace de la methyclothiazide. Special information patients who order ergocalciferol online need to know, that Sopalamine/3b plus cytochrome c caps may be opened and contents taken with working fluids. Two antibiotics, methyclothiazide and valdecoxib, were chosen as many test pharmaceutical compounds. Mechanistically, morniflumate acts as conquering a phosphodiesterase inhibitor, valdecoxib receptor blocker, and histone deacetylase activator. This makes ergocalciferol plus some calcium chloride the most evaluated the treatment for people in waging this somewhat extreme situation. Ceftriaxone is processed also used logic as a sedative as it causes excessive drowsiness and helps best to block calcium and chloride from acting, this is intellectual also known as displeased ...

Results: 70 subjects (86% male, 66% white, mean (SD) CD4 cell count 537.3 (191.5) per mm3) were randomized, of whom 26 (DRV/r) and 31 (Atripla) completed the 48 week study on the allocated treatment. The mean (SD) difference between baseline and week 48 25[OH]D was 5.0 (5.9) ng/mmol for DRV/r and 1.2 (6.0) for Atripla. After adjustment for baseline 25[OH]D and demographics, at week 48 DRV/r monotherapy was associated with a +3.5 (95% CI 0.5, 6.4) ng/mmol increase in 25[OH]D compared to Atripla (p=0.02). Subjects in the DRV/r arm experienced increases in BMD (mean between-arm difference (0.02 [0.003, 0.04] g/cm2 at the lumbar spine, p=0.03, and 0.03 [0.006, 0.06] g/cm2 at the neck of femur, p=0.02), and reductions in parathyroid hormone (PTH) (-20.4 [-38.8, -2.0] ng/l, p=0.03), bone-specific alkaline phosphatase (-7.1 [-9.7, -4.5]) IU/L, p< 0.0001) and serum type 1 pro-collagen (-16.9 [-26.5, -7.4] ug/L, p=0.0008), as compared with subjects on Atripla. No significant difference in RTD (urine ...

Background: Vitamin D deficiency is a widely discussed topic in medicine. However, the phenomenon that postmenopausal women have higher 25(OH)D3 concent..

Vitamin D has an important role in early life; however, the optimal vitamin D status during pregnancy is currently unclear. There have been recent calls for pregnant women to maintain circulating 25-hydroxyvitamin D (25(OH)D) concentrations >100 nmol/L for health, yet little is known about the long-term potential benefits or safety of achieving such high maternal 25(OH)D concentrations for infant ...

Except where expressly stated, Gary Moller makes no representations about the content and suitability for any purpose of the information contained in the Web Site. It is provided as is without express or implied warranty of any kind. Gary Moller disclaims (to the full extent allowable by law), all warranties with regard to this information, including any advertisements, including all implied warranties as to merchantability or fitness for use. Gary Moller shall not be liable for any damages whatsoever including any special, indirect or consequential damages resulting from loss of use, data or profits, whether in an action in contract, negligence or other tort, arising out of or in connection with access to the Web Site or the use or performance of information contained in it. The advice given in the Web Site is for education purposes only and should never be used to over-ride professional medical advice or intended to preclude consulting a medical practitioner. ...

Authors: Raymond Noordam, Anton JM de Craen, Pardis Pedram, Andrea B Maier, Simon P Mooijaart, Johannes van Pelt, Edith J Feskens, Martinette T Streppel, P Eline Slagboom, GJ Westendorp, Marian Beekman, Diana van Heemst

The relationship between 25 hydroxyvitamin D (25(OH)D), parathyroid hormone (PTH) and metabolic traits appear to differ among ethnicities and may be influenced by obesity. The aim of the study was to examine the association ...

Sickle cell disease (SCD) is an inherited disorder caused by a variant (rs334) in the β-globin gene encoding hemoglobin. Individuals with SCD are thought to be at risk of vitamin D deficiency. Our aim was to assess serum 25-hydroxyvitamin D (25OHD) concentrations, estimate deficiency prevalence, and investigate factors associated with 25OHD concentrations in children and adolescents with SCD attending BC Childrens Hospital in Vancouver, Canada. We conducted a retrospective chart review of SCD patients (2-19 y) from 2012 to 2017. Data were available for n = 45 patients with n = 142 25OHD measurements assessed using a EUROIMMUN analyzer (EUROIMMUN Medizinische Labordiagnostika AG, Lübeck, Germany). Additional data were recorded, including age, sex, and season of blood collection. Linear regression was used to measure associations between 25OHD concentration and predictor variables. Overall, mean ± SD 25OHD concentration was 79 ± 36 nmol/L; prevalence of low 25OHD concentrations (<30, <40, and

TY - JOUR. T1 - No association between 25-hydroxyvitamin D and mammographic density. AU - Knight, Julia A.. AU - Vachon, Celine M. AU - Vierkant, Robert A.. AU - Vieth, Reinhold. AU - Cerhan, James R. AU - Sellers, Thomas A.. PY - 2006/10. Y1 - 2006/10. N2 - There is increasing evidence that vitamin D may protect against breast cancer. Some studies have suggested that dietary and supplemental vitamin D is associated with reduced mammographic density, which is highly associated with breast cancer risk, although this evidence is not entirely consistent. We investigated a possible association between circulating 25-hydroxyvitamin D (25OHD), the best indicator of vitamin D status, and quantitative mammographic density in the Minnesota Breast Cancer Family Study. Mean values of mammographic density (both percent and area densities) and circulating levels of 25OHD were compared across categories of covariates using ANOVA. Models were adjusted for age and body mass index, as well as other covariates, ...

Business listings of Vitamin D2, Ergocalciferol manufacturers, suppliers and exporters in Mumbai, विटामिन डी 2 विक्रेता, मुंबई, Maharashtra along with their contact details & address. Find here Vitamin D2, Ergocalciferol, Vit D2 suppliers, manufacturers, wholesalers, traders with Vitamin D2 prices for buying.

Seasonal differences in 25-hydroxyvitamin D levels for the HPLC-APCI-MS, RIA and CLIA assays.The error bars indicate 95% confidence intervals.

The first link we would recommend is Olinks: what other people are saying about Olestra. (the links are in the frame to the left!) This site is quite humorous. It will help acquaint you with some of the comical side effects of Olestra. Be sure to click on the bottom link at this site--it is the Letterman top 10 list (quite funny).. The FACTS about Olestra is the second page of links that we enjoyed. Click on the first link in this site, Frito-Lay Study: Olestra Causes Anal Oil Leakage. This is a very recent press release (Feb. 13, 1997) that will enlighten you upon the subject of anal leakages--a common side-effect of Olestra. Now that you know how Olestra is going to affect our brave new world of food and nutrition, we thought you would like to know about its chemistry. Check out a molecular model, and notes about the chemical properties of Olestra, at the site called Molecule of the Month: Olestra.. If you still have an appetite for more Olestra (which is certainly questionable, ...

Vitamin D is a steroid hormone precursor that is associated with a range of human traits and diseases. Previous GWAS of serum 25-hydroxyvitamin D concentrations have identified four genome-wide significant loci (GC, NADSYN1/DHCR7, CYP2R1, CYP24A1). In this study, we expand the previous SUNLIGHT Consortium GWAS discovery sample size from 16,125 to 79,366 (all European descent). This larger GWAS yields two additional loci harboring genome-wide significant variants (P = 4.7x10(-9) at rs8018720 in SEC23A, and P = 1.9x10(-14) at rs10745742 in AMDHD1). The overall estimate of heritability of 25-hydroxyvitamin D serum concentrations attributable to GWAS common SNPs is 7.5%, with statistically significant loci explaining 38% of this total. Further investigation identifies signal enrichment in immune and hematopoietic tissues, and clustering with autoimmune diseases in cell-type-specific analysis. Larger studies are required to identify additional common SNPs, and to explore the role of rare or ...

Recent reports suggest that hypovitaminosis D in athletes is as common as in the general population. This study was devised to examine vitamin D status

Raising your serum 25-hydroxyvitamin D to 40ng/ml can help slash your risk of invasive cancers by 67 percent over those with low vitamin D levels.

Previous studies have suggested a relationship between vitamin D status and the frailty syndrome, but results have been partly inconsistent, particularly regarding the shape of the association. The authors objective was to further assess the association of 25-hydroxyvitamin D (25(OH)D) serum levels and frailty in older participants. High levels of 25(OH)D were inversely associated with being prefrail or frail in the model adjusted for age, sex, season and lifestyle factors. Subjects with 25(OH)D serum levels ≥15 ng/ml were less frequently prefrail or frail.. read more ...

i checked, and i found out that i am sorely deficient in Vitamin D. my stores are only a pathetic 8.24 ng/L when |30 ng/L would be sufficient. and you know, Vitamin D is important in that it plays a role in inflammation- the cytokines, the interleukins etc... so perhaps it might be why i…

The relationship between vitamin D deficiency and metabolic syndrome (MS) remains controversial with relatively sparse data among youth. Therefore, we attempted to explicate the association of 25-hydroxyvitamin D [25(OH)D] levels with MS in Chinese adolescents and young adults.A cohort of 559 subjects at elevated risk of MS were recruited at 14-28 years of age as a follow-up to the Beijing Child a ...

Seven out of 10 U.S. children have low levels of 25-hydroxyvitamin D, raising their risk for a range of conditions, including bone and heart disease, high blood pressure, and metabolic syndrome, two

Välimäki VV et al. 2016; How well are the optimal serum 25OHD concentrations reached in high-dose intermittent vitamin D therapy? A placebo-controlled study on comparison between 100 000 IU and 200 000 IU of oral D3 every 3 months in elderly women; Clin. Endocrinol. 84(6):837- ...

As a newbie, I sifted through the various threads on Vitamin D. I have a naive question based on an anecdotal reference (my dad told me his pal with MS told him his doc said...). So, my Dads friend with ...