Chem. Abstr. Name: N-Phenyl-2-naphthalenamine A. Evidence for carcinogenicity to humans (inadequate) No excess of bladder tumours was found among men in a rubber processing factory with known exposure to N-phenyl-2-naphthylamine (which contained small amounts of 2-naphthylamine); however, a study of rubber workers who were not exposed to 2-naphthylamine did show an increased incidence of bladder tumours. In the latter study, the men were exposed to several compounds, which probably included N-phenyl-2-naphthylamine [ref: 1]. B. Evidence for carcinogenicity to animals (limited) N-Phenyl-2-naphthylamine was tested for carcinogenicity by oral administration in mice, rats, hamsters and dogs. No carcinogenicity was reported in most experiments [ref: 1-4]. In one experiment, the total tumour incidence and the incidence of hepatocellular tumours were increased in male mice of one strain [ref: 1]. In another experiment, two rare kidney tumours were seen in female mice [ref: 2]. Subcutaneous ...
In one study, in one factory, of men with known exposure to N-phenyl-2-naphthylamine in rubber processing under controlled conditions, there was no indication of an excess incidence of bladder tumours. However, a broader study of rubber workers who had no exposure to 2-naphthylamine has shown an increased risk of bladder tumours. In the latter study, exposure was mixed but probably included exposure to N-phenyl-2-naphthylamine for many workers. These findings do not permit an assessment of the presence or absence of an elevated risk for cancer of the urinary bladder in persons exposed to N-phenyl-2-naphthylamine. 1 Subsequent to the finalization of this evaluation by the Working Group in June 1977, the Secretariat became aware of an abstract of a paper by Checkoway et al. (1977) describing a retrospective cohort mortality study of bladder cancers in 4 major US rubber companies between 1964-1973; however, the study cannot be evaluated on the basis of the data presented.. Subsequent evaluation: ...
N-Phenyl-1-naphthylamine C16H13NN-Phenyl-1-naphthylamines production and use as an antioxidant in various lubrication oils and as both a protective agent and
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Benzamide, 4-bromo-N-(1H-indol-3-ylphenylmethyl)-N-phenyl- | C28H21BrN2O | CID 71399214 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
You are viewing an interactive 3D depiction of the molecule 6-(cyclohexylmethoxy)-n-phenyl-1h-purin-2-amine (C18H21N5O) from the PQR.
Those results were in agreement with the antimicrobial and hemolytic activities of CODs. Moreover, we found that the studied peptides permeated both the outer and inner cytoplasmic membranes of Escherichia coli. This was determined by measuring changes in the fluorescence of probe N-phenyl-1-naphthylamine and detecting cytoplasmic β-galactosidase released during the interaction of peptides with E. coli cells. Transmission electron microscopy revealed that treatment of E. coli with one of the COD analogs caused leakage of bacterial content mainly from the septal areas of the ...
The theoretical approach to the study of aniline polymerization mechanism has been based on the MNDO-PM3 semi-empirical quantum chemical computations of the heat of formation of aniline dimer and trimer intermediates. The oxidation in aqueous medium without added acid is analyzed. The aniline nitrenium cation is proposed to be the reactive electrophilic species generated by the oxidation of aniline with a two-electron oxidant, ammonium peroxydisulfate, in the initiation phase. 4-Aminodiphenylamine and its fully oxidized form, N-phenyl-1,4-benzoquinonediimine, are the main dimeric products. 2-Aminodiphenylamine and its fully oxidized form, N-phenyl-1,2-benzoquinonediimine, are the most important side products of aniline dimerization. The influence of protonation on the oxidizability of aniline and reaction intermediates was studied. The dominant aniline oligomers have been shown to be linear as well as branched. The importance of reactivity difference between fully oxidized aniline oligomers ...
12236-11-2 R 79579 1,3-Dioxane, 2,4-dimethyl-6-phenyl- (3Z)-3-(2-furylmethylidene)-1H-indol-2-one Amines, C12-14-tert-alkyl, bis(4-((5-chloro-2-hydroxyphenyl)azo)-2,4-dihydro-5-methyl-2-phenyl-3H-pyrazol-3-onato(2-))cobaltate(1-) (1:1) N-phenyl-6-(tribromomethyl)-1,3,5-triazine-2,4-diamine N-[(chloro-dipropan-2-yloxyphosphoryl-methylidene)amino]-4-methyl-aniline 10,11-dithiocyanatoundecanoic acid Androsol acetate Trihydrogen tris((4-((4-(diethylamino)phenyl)(4-(ethyl(3-sulphonatobenzyl)amino)-o-tolyl)methylene)-3-methylcyclohexa-2,5-dien-1-ylidene)(ethyl)(3-sulphonatobenzyl)ammonium), aluminium salt
NFC is the only domestic producer of PANA (n-phenyl-1-naphthylamine), an anti-oxidant used in synthetic lubricants, rubber products and as an organic intermediate. Three options offered are molten liquid, solid and flake ...
Dr. Jing Zhang, Post-doctoral fellow (2013-16) Novel diagnostic tools for blast trauma, pre-symptomatic acute infectious disease and severe stress. Dr. Diana Campbell, Doctoral thesis (2012-16) Cross-regulation between thyroid and androgen hormones in amphibians. Dr. Sonja Bissegger, Doctoral thesis (2013-16) Role of 5 alpha-reductase type 3 and 5 beta-reductase in reproduction. Melody Kang, NSERC-USRA student (2016) DNA methylation in fish. Marie Sereneo, Honours thesis (2015-16) Effect s of diluted bitumen in rainbow trout. Tyler Rozario, Biotechnology placement student (2016) from St. Lawrence College, Kingston, ON. Giselle Hunt, NSERC-USRA student (2015) Analyzing the effects of dietary N-Phenyl-1-naphthylamine in snapping turtles (Chelydra sepentina). Steven Davis, SWEP student (2015) Animal care facility manager. Sean Chisnell, Biotechnology placement student (2015) from St. Lawrence College, Kingston, ON. Nova Zhao, NSERC-USRA student (2014) Development of in situ hybridization assays to ...
Wet-lab validated real-time PCR primer assays for your biological pathway of interest. Select your gene target of interest using an interactive pathway map, and select your plate.
(2-(4-(2-benzimidazol-2ylthio)ethyl)piperazin-1yl)-N-(2,4-bis(methylthio)-6-methyl-3-pyridyl)acetamide: a selective ACAT-1 inhibitor that suppresses fatty streak lesions in fat-fed hamsters without affecting plasma cholesterol levels; structure in first source
77562-96-0 - BNTJVEIUADBJII-UHFFFAOYSA-N - Propanamide, N-(1-methyl-2-(4-(1-methylethyl)-1-piperazinyl)ethyl)-N-phenyl-, ethanedioate, hydrate (2:4:1) - Similar structures search, synonyms, formulas, resource links, and other chemical information.
Sulfonation products of (N-phenyl-4-[[4-(phenylamino)phenyl][4-(phenylimino)cyclohexa-2,5-dien-1-ylidene]methyl]aniline, monohydrochloride and 4,4-[(4-iminocyclohexa-2,5-dien-1-ylidene)methylene]bis[N-phenylaniline], monohydrochloride), sodium salts ...
Chemical name:N-Phenyl-β-NaphthylamineMolecular formula:C16H13N Molecular structure: Molecular weight:219.29 CAS NO.:135-88-6Executive standard:Q/12HG 4521
Looking for Brönner's acid? Find out information about Brönner's acid. C10H6 SO3H A colorless, water-soluble naphthylamine sulfonic acid that forms needle crystals; used in dyes. Also spelled Broenners acid Explanation of Brönner's acid
good quality strength mineral rack gold ore flotation cell Simply said a Flotation Collectors is a chemical used to make the surface of minerals which is metallic hydrophobic or in layman s term afraid of water or water hating as others like to say This chemical used will behaved in a way as a wax would when you applied it to your car After wax or hydrophobic agent is adhered to Get Price ...
The PDB archive contains information about experimentally-determined structures of proteins, nucleic acids, and complex assemblies. As a member of the wwPDB, the RCSB PDB curates and annotates PDB data according to agreed upon standards. The RCSB PDB also provides a variety of tools and resources. Users can perform simple and advanced searches based on annotations relating to sequence, structure and function. These molecules are visualized, downloaded, and analyzed by users who range from students to specialized scientists.
Pantoprazole Sodium Sesquihydrate ;. Sodium 5-(difluoromethoxy)-2-[(RS)-[(3,4-dimethoxypyridin-2-yl)methyl]sulfinyl]benzimidazol-1-ide ;. CAS # 138786-67-1 (anhydrous) ; 164579-32-2 (sesquihydrate) ; 718635-09-7 (hydrate) ;. C16H14F2N3NaO4S (anhydrous) ; MW: 405.35 ;. C16H14F2N3NaO4S . 1.5 H2O ; Mol. Wt.: 432.40. Supplied as sesquihydrate for lab research use (not for human use) ;. ...
TY - JOUR. T1 - Glycosylation enhances the aqueous sensitivity and lowers the cytotoxicity of a naphthalimide zinc ion fluorescence probe. AU - Dong, Lei. AU - Zang, Yi. AU - Zhou, Dan. AU - He, Xiao Peng. AU - Chen, Guo Rong. AU - James, Tony D.. AU - Li, Jia. PY - 2015/7/28. Y1 - 2015/7/28. N2 - With this research we demonstrate that glycosylation of a naphthalimide zinc ion probe, using click chemistry, leads to an improvement of the aqueous sensitivity, working pH range and targeting ability for specific cells, together with significantly reduced cytotoxicity.. AB - With this research we demonstrate that glycosylation of a naphthalimide zinc ion probe, using click chemistry, leads to an improvement of the aqueous sensitivity, working pH range and targeting ability for specific cells, together with significantly reduced cytotoxicity.. UR - http://www.scopus.com/inward/record.url?scp=84936970791&partnerID=8YFLogxK. UR - http://dx.doi.org/10.1039/c5cc04357c. U2 - 10.1039/c5cc04357c. DO - ...
No detectable medication was present in any infant exposed to paroxetine or fluvoxamine. Detectable medication (parent and/or metabolite) was present in 24% (8/33) of the serum samples obtained from infants exposed to sertraline. Concentrations of sertraline and desmethylsertraline, when present, were 2-8 and 2-12 ng/ml, respectively.. Four mothers (nos 5, 16, 24 and 49) titrated their dose of the antidepressant upwards to help their mood and obtained repeat serum samples on themselves and their infants after being on the higher medication dosage for at least 1 week.. Maternal dosage of sertraline correlated highly with infant serum concentration of desmethylsertraline after controlling for infant age, gestational exposure and breast-feeding exposure (parameter estimate=0.09, d.f.=1, P=0.03). Maternal serum concentrations of sertraline and desmethylsertraline correlated highly with infant serum concentration of desmethylsertraline (parameter estimate=0.20, d.f.=1, P,0.001 and parameter ...
HYBRID BLOCK COPOLYMER MICELLES WITH MIXED STEREOCHEMISTRY FOR ENCAPSULATION OF HYDROPHOBIC AGENTS - diagram, schematic, and image 32 ...
Materials. 17-Allylamino-demethoxygeldanamycin (17-AAG) was provided by the National Cancer Institute and Kosan Biosciences (Hayward, CA). 2,6-Dichlorophenol-indophenol (DCPIP), NADH, NADPH, sodium borohydride, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT), bovine serum albumin (BSA), β-lapachone, N-phenyl-1-naphthylamine, d(−)-penicillamine, and mouse monoclonal (IgG) and anti-actin antibodies were obtained from the Sigma Chemical Co. (St. Louis MO). Yeast Hsp90 and radicicol were obtained from Alexis (San Diego, CA). Human Hsp90 was a kind gift from Dr. David Toft (Mayo Clinic College of Medicine, Rochester, MN). Recombinant human NQO1 (rhNQO1) was purified from Escherichia coli as described previously ( 19). The activity of rhNQO1 was 4.5 μmol DCPIP/min/mg protein. Malachite green phosphate assay kit was obtained from BioAssay Systems, Inc. (Hayward, CA). Mouse anti-Hsp70 and rabbit anti-Raf-1 antibodies were obtained from Stressgen (Vancouver, British Columbia, ...
Page contains details about 1,8-naphthalimide derivative/cucurbit[8]urils nanovesicles . It has composition images, properties, Characterization methods, synthesis, applications and reference articles : nano.nature.com
The effect of the polycation polyethyleneimine (PEI) on the permeability properties of the Gram-negative bacterial outer membrane was investigated using Escherichia coli, Pseudomonas aeruginosa and Salmonella typhimurium as target organisms. At concentrations of less than 20 μg ml-1, PEI increased the bacterial uptake of 1-N-phenylnaphthylamine, which is a hydrophobic probe whose quantum yield is greatly increased in a lipid environment, indicating increased hydrophobic permeation of the outer membrane by PEI. The effect of PEI was comparable to that brought about by the well-known permeabilizer EDTA. Permeabilization by PEI was retarded but not completely inhibited by millimolar concentrations of MgCl2. PEI also increased the susceptibility of the test species to the hydrophobic antibiotics clindamycin, erythromycin, fucidin, novobiocin and rifampicin, without being directly bactericidal. PEI sensitized the bacteria to the lytic action of the detergent SDS in assays where the bacteria were pretreated
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1-Naphthylamine, 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine, 3,4-Dihydroxyphenylacetic Acid, Abnormalities, Drug-Induced, Acetylcholine, Acetylcholinesterase, Aconitine, Acoustic Stimulation, Actins, Acute Disease, Acyltransferases, Adaptation, Physiological, Adenylate Cyclase, Adiponectin, Adipose Tissue, Administration, Cutaneous, Administration, Oral, Adolescent, Adrenergic alpha-2 Receptor Antagonists, Adrenergic alpha-Antagonists, Adult, Aerosols, Affect, Age Factors, Age of Onset, Aged, Aged, 80 and over, Aging, Air Pollutants, Alcohol Deterrents, Alcohol Drinking, Alcoholism, Alkaloids, Allosteric Regulation, alpha-Methyltyrosine, Alzheimer Disease, Amino Acids, Amino Acids, Branched-Chain, Amphetamine, Amygdala, Anabasine, Anal Canal, Analgesics, Analysis of Variance, Animals, Animals, Newborn, Animals, Suckling, Anthelmintics, Anti-Anxiety Agents, Anti-HIV Agents, Anticonvulsants, Antidepressive Agents, Antineoplastic Agents, Hormonal, Antioxidants, Antipsychotic Agents, ...
A pilot study looking at the potential impact of e-cigarettes on the health of those who use them found a strong correlation between vaping and the presence of two carcinogens known to cause bladder cancer. The preliminary study analyzed the urine of 13 e-cigarette users and 10 non-user controls. The e-cigarette users had a median of 26 months of use. Researchers found two known carcinogens, otoluidine and 2-naphthylamine, in the samples of all but one of the e-cigarette users. Neither toxin was found in the nonuser samples. The study suggests that e-cigarettes are not without their own risks, despite being ... Read More. ...
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glycyl-aspartyl-aspartyl-aspartyl-aspartyl-lysine-2-naphthylamide: synthetic substrate linked via amide bond to fluorophore 2-naphthylamine
Cancer is an ever-increasing problem that is yet to be harnessed. Frequent mutations make this pathology very variable and, consequently, a considerable challenge. Intriguingly, mitochondria have recently emerged as novel targets for cancer therapy. A group of agents with anti-cancer activity that induce apoptosis by way of mitochondrial destabilisation, termed mitocans, have been a recent focus of research. Of these compounds, many are hydrophobic agents that associate with various sub-cellular organelles. Clearly, modification of such structures with mitochondria-targeting moieties, for example tagging them with lipophilic cations, would be expected to enhance their activity. This may be accomplished by the addition of triphenylphosphonium groups that direct such compounds to mitochondria, enhancing their activity. In this paper, we will review agents that possess anti-cancer activity by way of destabilizing mitochondria and their possible targets. We propose that mitochondrial targeting, in
During your next cycle, we will work the clomid to mg. to be monitored days of your memory. We will. Joint for some encouragement bc DH murmurs on 1116 and we will have to other 6 more problems adipex and sertraline try again. He also gave me a good tip, he said after you get your toughest surge for ovulating, have sex the DAY Tinted in the blurred position being sure to keep your I coped cd and od adipex and sertraline cd still low and EWCM has advised away. I will keep BDing that i am sure, but just wondering if any of you found a rash as to how many days after your last Clomid choke that O came. I reveal most doctors like to see you ovulate around 5 - 9 adipex and sertraline after taking your last dose. More:. ...
Crystalline sertraline free base is made by treating a sertraline salt with a base and recovering the sertraline base in crystalline form.
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