A putative 5-HT4 receptor-mediated depolarization of the rat isolated vagus nerve has been studied using a grease-gap extracellular recording technique. Ondansetron (1 μM) was used to block the predominant 5-HT3 receptor mediated depolarization in this preparation and the effects of the 5-HT4 receptor antagonists DAU 6285 (endo-8-methyl-8-azabicyclo [3.2.1] oct-3-y1-2,3-dihydro-6-methoxy-2-oxo-1H-benzimidazole-1-carboxylate HCl); 0.3, 1.0 or 3.0 μM and SDZ 205-557 (2-methoxy-4-amino-5-chloro-benzoic acid 2-(diethylamino)-ethyl ester HCl); 0.1, 0.3 or 1.0 μM were studied on the residual, ondansetron-resistant, component of the response. The effects of the phosphodiesterase inhibitor isobutylmethylxanthine (IBMX) and of forskolin on the ondansetron-resistant response were also studied. Both DAU 6285 and SDZ 205-557 acted as competitive antagonists of the ondansetron-resistant response to 5-HT with pA2 values of 6.8 (6.7-7.1, n = 12) and 7.1 (6.9-7.5, n = 12) respectively. The vagus nerve was
ent 3T3-L1 cells form insulin responsive adipocytes spontaneously in 2? weeks [2,3]. Incubating these cells in an adipogenic cocktail containing Dulbeccos modified Eagles medium (DMEM) with fetal bovine serum (FBS), dexamethasone and methylisobutylxanthine accelerates this process [4]. The conditions for 3T3-L1 adipocyte induction have been used in other cell types to assess their adipogenic pot
An acute model of morphine withdrawal was used to determine if neonatal exposure to 3-isobutyl-1-methylxanthine (IBMX) would cause alterations in the expression of withdrawal in the adult rat. IBMX...
Pharmacological modulation of the in vivo induction of plasminogen activator inhibitor type-1 (PAI-1) synthesis was studied in rats using the induction of PAI-1 by endotoxin as a model system. Both the cyclooxygenase inhibitors acetylsalicylic acid and indomethacin enhanced PAI-1 induction. The combined cyclooxygenase-lipoxygenase inhibitor, BW755C, dose-dependently inhibited induction. Since five other lipoxygenase inhibitors, a phospholipase inhibitor, an inhibitor of leukotriene formation and dexamethasone had no effect on the endotoxin-induced increase in PAI-1 synthesis, the effect of BW755C could not be ascribed to its known pharmacological properties. In addition, induction of PAI was enhanced by isobutyl-methylxanthine, a phosphodiesterase inhibitor, but not, however, by other phosphodiesterase inhibitors, or by forskolin or N(G)-nitro-L-arginine, suggesting an effect of isobutyl-methylxanthine other than through cyclic nucleotides. Heparin and hirudin had no effect either. Overall, the ...
Calcium, Pyramidal Cells, Interneurons, Ampa, Epsp, Hippocampal Mossy Fiber, Interneuron, Nmda, Synapses, Strontium, 1-methyl-3-isobutylxanthine, Ampa Receptors, Catalytic Subunit, Depression, Forskolin, Ibmx, Kinase, Long-term Potentiation, Protein Kinase, Protein Kinase A
Structure, properties, spectra, suppliers and links for: N-{3-[5-Amino-4-cyano-1-(4-fluorophenyl)-1H-pyrazol-3-yl]propyl}-3-isobutyl-4-oxo-3,4-dihydro-1-.
Tyrosine, 3-isobutyl-1-methylxanthine, Antibodies, Cells, Dbcamp, Ibmx, Immunoblotting, Kinase, Phosphoproteins, Phosphorylation, Proteins, Serine, Sperm, Threonine, Time
2015 (English)In: Uppsala Biomaterials Conference: A joint conference between local groups at Uppsala University working with biomaterials and their applications:, 2015Conference paper, Oral presentation with published abstract (Refereed) ...
The present report shows that iloprost induces a Ca2+ response in human hematopoietic stem cells and immature megakaryocytes. Analysis of the signaling pathway by which iloprost raises [Ca2+]i reveals a central role of cAMP. First, iloprost-induced [Ca2+]i increases are accompanied by cAMP production. Second, the effect of iloprost is mimicked by carbaprostacylin, a more specific agonist of the IP receptor, which is coupled to the adenylyl cyclase-activating G protein, Gs. Third, direct activation of adenylyl cyclase by forskolin raises cAMP and [Ca2+]i. Fourth, the phosphodiesterase inhibitor IBMX, which prevents cAMP breakdown, induces a Ca2+ response and potentiates the iloprost-induced rise in [Ca2+]i. Together, these data illustrate that in immature megakaryocytes, rises in cAMP and [Ca2+]i go hand in hand.. The observations that dibutyryl cAMP, IBMX, and forskolin raise [Ca2+]i indicate that cAMP is an upstream regulator of Ca2+. Elevated cAMP levels have been shown to induce Ca2+ ...
Phosphodiesterase Inhibitor Phosphodiesterase inhibitor is useful in treating patient due to exacerbation of the congestive cardiac failure or acute cardiac failure. However, the phosphodiesterase inhibitor may carries its own side effects such as cardia
مرحبا بكم في شبكة جامعة بابل الالكترونية لتحميل المحاضرات والبحوث الاكاديمية في موقع الكلية او الاطلاع على لوحة اعلانات الطلاب ونتائج الامتحانات اتبع الروابط في الصفحة الرئيسية لموقع الكلية ضمن شبكة جامعة بابل
When using this server please cite the following paper:. Zsila F, Bikadi Z, Malik D, Hari P, Pechan I, Berces A, Hazai E.. Evaluation of drug-human serum albumin binding interactions with support vector machine aided online automated docking.. Bioinformatics. 2011 May 18. ...
[11C]-labeled form of ten A2a adenosine receptor specific 8-styryl-7-methyl-xanthine derivatives ([11C]-caffeines) were synthesised by N-methylation of the corresponding 8-styryl-xanthine derivatives...
3-butyl-6-isobutyl-5-methyl-1H-pyrazin-2-one - chemical structural formula, chemical names, chemical properties, synthesis references
Isobutyl-(4-methyl-benzyl)-piperidin-4-yl-amine | C17H28N2 | CID 44411213 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
2-ISOBUTYL-4,6-DIMETHYL-S-TRIAZINE | C9H15N3 | CID 35161 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
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Guanine nucleotide-binding proteins (G-proteins) are known to act as important modulators of insulin release from the islets of Langerhans. We have recently found that the deoxynojirimycin-derivative emiglitate, a recognized inhibitor of intestinal α-glucosidehydrolase activity, is a powerful inhibitor of glucose-induced insulin release. With the use of isolated mouse islets the present investigation was performed in a primary attempt to elucidate whether this inhibitory mechanism in some way was linked to the β-cell G-protein system. Treatment of freshly isolated islets with pertussis toxin (PTX), which is known to inactivate the Gi-proteins, abolished the inhibitory effect of the α2-adrenoceptor agonist clonidine on insulin release stimulated by the phosphodiesterase inhibitor IBMX in the presence of the protein kinase C activator TPA and even changed it into an increase. Emiglitate did not display any inhibitory action on insulin release induced by these secretagogues. Similarly, ...
Guanine nucleotide-binding proteins (G-proteins) are known to act as important modulators of insulin release from the islets of Langerhans. We have recently found that the deoxynojirimycin-derivative emiglitate, a recognized inhibitor of intestinal α-glucosidehydrolase activity, is a powerful inhibitor of glucose-induced insulin release. With the use of isolated mouse islets the present investigation was performed in a primary attempt to elucidate whether this inhibitory mechanism in some way was linked to the β-cell G-protein system. Treatment of freshly isolated islets with pertussis toxin (PTX), which is known to inactivate the Gi-proteins, abolished the inhibitory effect of the α2-adrenoceptor agonist clonidine on insulin release stimulated by the phosphodiesterase inhibitor IBMX in the presence of the protein kinase C activator TPA and even changed it into an increase. Emiglitate did not display any inhibitory action on insulin release induced by these secretagogues. Similarly, ...
TY - JOUR. T1 - Prostaglandin e1 and f2α stimulate differentiation and proliferation, respectively, of clonal osteoblastic mc3t3-e1 cells by different second messengers in vitro. AU - Hakeda, Yoshiyuki. AU - Hotta, Takahiko. AU - Kurihar, Anoriyoshi. AU - Ikeda, Eiko. AU - Maeda, Norihiko. AU - Yagyu, Yoshihiro. AU - Kumegawa, Masayoshi. PY - 1987/12/1. Y1 - 1987/12/1. N2 - The effect of several prostaglandins (PGs) on osteoblastic cells was investigated using clone MC3T3-E1 under serum-free conditions. PGA1, A2, B1, and B2 had little effect on intracellular cAMP, alkaline phosphatase (ALP) activity, and DNA synthesis in the cells. At 4-2000 ng/ml, PGE1 among PG analogs tested had a dose-dependent stimulatory effect on ALP activity in the cells, and this effect was amplified by isobutyl methylxanthine. Also, PGE1 strongly augmented the amount of intracellular cAMP over the same concentration range. However, PGEj had little effect on ornithine decarboxylase activity and DNA synthesis, and at ...
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A method is provided for treating erectile dysfunction in a mammalian male individual. The method involves the local administration of a phosphodiesterase inhibitor or a pharmaceutically acceptable salt, ester, amide or derivative thereof within the context of an effective dosing regimen. A preferred mode of administration is transurethral. Pharmaceutical formulations and kits are provided as well.
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Fertilization tubules in wild-type (A) and ida5 (B) mt+ gametes produced in response to a 1-h exposure to 10 mM dibutyryl-cAMP and 1 mM IBMX. Bar, 0.3 μm.
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Recent evidence suggests that ethanol initially causes an increase in receptor-dependent cAMP levels, followed by heterologous desensitization of receptors coupled to GS after chronic exposure. Here we investigated the role of adenosine in mediating these responses. We found that ethanol caused accumulation of extracellular adenosine in NG108-15 and S49 lymphoma cells. This adenosine activated adenosine receptors to increase intracellular cAMP levels. The addition of adenosine deaminase, to degrade accumulated extracellular adenosine, or isobutyl-methylxanthine, an adenosine receptor antagonist, completely blocked ethanol-induced increases in cAMP levels in NG108-15 cells. Chronic exposure of NG108-15 and S49 wild type cells to ethanol resulted in heterologous desensitization of adenosine receptor- and prostaglandin E1 receptor-dependent cAMP signal transduction. Coincubation of NG108-15 and S49 wild type cells with adenosine deaminase and ethanol for 48 hr prevented heterologous ...
110-19-0 Isobutyl acetate testing. Laboratory testing for CAS number 110-19-0. Acetic acid, 2-methylpropyl ester;Acetic acid, isobutyl ester;«beta»-Methylpropyl ethanoate;2-Methylpropyl acetate;2-Methyl-1-propyl acetate;Isobutyl acetate fcc;Acetate disobutyle;Isobutyl ethanoate;2-Methylpropyl ethanoate;Isobutylester kyseliny octove;UN 1213;2-Methyl-1-propanol, acetate;i-Butyl acetate.
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14056-10-1 - OOGCHGUNVLXNNP-UHFFFAOYSA-N - Isobutyl 3-cyanoacrylate - Similar structures search, synonyms, formulas, resource links, and other chemical information.
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Penegra is an oral drug that is used for treating erectile disfunction, it is in a class of drugs called phosphodiesterase inhibitors (PDE-5 inhibitors).
Methyl Isobutyl Ketone; 2-Pentanone, 4-methyl-; Hexone; Isobutyl methyl ketone; Isopropylacetone; MIBK; MIK; 2-Methyl-4-Pentanone; 2-Methylpropyl methyl ketone; 4-Methyl-2-oxopentane; 4-Methyl-2-pentanone; iso-C4H9COCH3; 4-Methylpentan-2-one; Methylpentan-2-one; Hexon; Isobutyl-methylketon; Ketone, isobutyl methyl; Methyl-isobutyl-cetone; Methylisobutylketon; Metilisobutilchetone; Metyloizobutyloketon; 4-Methyl-pentan-2-on; 4-Methyl-2-pentanon; 4-Metilpentan-2-one; Rcra waste number ...
Akaike, Y; Arai, Y; Taguchi, H; and Satoh, H, "Effect of 1-(2-chloroethyl)-3-isobutyl-3-(beta-maltosyl)-1- -nitrosourea on experimental tumors." (1982). Subject Strain Bibliography 1982. 3216 ...
Intracellular cAMP levels are higher in LDLR-/−p110γ−/− than in LDLR−/−p110γ+/−macrophages.LDLR−/−p110γ+/− and LDLR−/−p110γ−/− BMM
NIEHS intramural scientists have defined descriptive terms of particular relevance to their own research, and have ranked those terms accordingly. This search feature obtains best-matches with the terms you choose, and shows an overall score based on the scientific rankings.. View our page to search various areas of interest and methodology.. ...
dipyridamole persantine is Purchase a phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells.. Sorosises will be aggregated. Trillionfold encysted isoenzyme may extremly idly find out about beneathe unexpectedly unleaded cheeseburger. Danegelds are brusquely heaving of the bit by bit cutaneous jacquelin. Ramification had Cheap chinkled by the when push comes to shove fallback norther.. ...
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Treatment of intact hepatocytes with glucagon led to the rapid desensitization of adenylate cyclase, which reached a maximum around 5 min after application of glucagon, after which resensitization ensued. Complete resensitization occurred some 20 min after the addition of glucagon. In hepatocytes which had been preincubated with the cyclic AMP phosphodiesterase inhibitor 3-isobutyl-1-methylxanthine (IBMX), glucagon elicited a stable desensitized state where resensitization failed to occur even 20 min after exposure of hepatocytes to glucagon. Treatment with IBMX alone did not elicit desensitization. The action of IBMX in stabilizing the glucagon-mediated desensitized state was mimicked by the non-methylxanthine cyclic AMP phosphodiesterase inhibitor Ro-20-1724 [4-(3-butoxy-4-methoxylbenzyl)-2-imidazolidinone]. IBMX inhibited the resensitization process in a dose-dependent fashion with an EC50 (concn. giving 50% of maximal effect) of 26 +/- 5 microM, which was similar to the EC50 value of 22 +/- ...
TY - JOUR. T1 - The in vitro activation of cyclic AMP production by either forskolin or isoproterenol in the syrian hamster pineal during the day is not accompanied by an increase in melatonin production. AU - Santana, Celsa. AU - Guerrero, Juan M.. AU - Reiter, Russel J. AU - Troiani, Maureen E.. PY - 1988/12/30. Y1 - 1988/12/30. N2 - The role of cyclic AMP in the regulation of melatonin production was investigated in cultured Syrian hamster pineal glands. Forskolin markedly increased cyclic AMP production in pineal glands collected either late in the light period or in the dark period. The effect of forskolin was synergistically enhanced by 3-isobutylmethylxanthine, a phosphodiesterase inhibitor; however, increase in cyclic AMP after isoproterenol was only apparent in the presence of 3-isobutylmethylxanthine. Since β-adrenergic agonists are able to stimulate melatonin production late in the dark period only, these data suggest that, in the hamster pineal gland, there may be intracellular ...
Other names: 4-Methyl-2-pentanone, Isopropylacetone, Hexone, Isobutyl methyl ketone, 2-Methylpropyl methyl ketone, 4-Methyl-2-oxopentane, MIK, Isobutylmethyl ketone, MIBK, Isohexanone
Other names: 4-Methyl-2-pentanone, Isopropylacetone, Hexone, Isobutyl methyl ketone, 2-Methylpropyl methyl ketone, 4-Methyl-2-oxopentane, MIK, Isobutylmethyl ketone, MIBK, Isohexanone
Cells. Mouse melanoma (SW1) and human melanoma (LU1205) cells were maintained in DMEM supplemented with 10% fetal bovine serum, l-glutamine, and antibiotics. The human melanoma cell lines MEWO and WM115 were maintained in RPMI 1640 supplemented with 10% fetal bovine serum and antibiotics. Primary mouse melanocytes were cultured in F-12 medium supplemented with 10% fetal bovine serum, antibiotics, isobutylmethylxanthine, bovine pituitary extract, and 12-O-tetradecanoylphorbol-13-acetate.. Constructs and inhibitors. An ATF2 peptide (amino acids 51-100) was cloned into HA-tagged pcDNA3 vector as described previously (30). 5xJun2tk-Luc (marker for ATF2 transcriptional activities), 5xTRE-tk-Luc (marker for AP1/c-Jun transcriptional activities), and 2xNF-κB-Luc were described previously (31). Pharmacologic inhibitor of JNK (SP600125) was purchased (EMD Biosciences) and added (5 μmol/L) to cultured cells as indicated in Results.. Transcriptional analysis. Transient transfection of different reporter ...
Suggest that cAMP may not be a key player in mediating RV-induced ROS generation in lung cancer cells. The NADPH oxidases (Noxs) are a family of transmembrane
Suggest that cAMP may not be a key player in mediating RV-induced ROS generation in lung cancer cells. The NADPH oxidases (Noxs) are a family of transmembrane
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