Zinc fingers. Medical search

Motifs in DNA- and RNA-binding proteins whose amino acids are folded into a single structural unit around a zinc atom. In the classic zinc finger, one zinc atom is bound to two cysteines and two histidines. In between the cysteines and histidines are 12 residues which form a DNA binding fingertip. By variations in the composition of the sequences in the fingertip and the number and spacing of tandem repeats of the motif, zinc fingers can form a large number of different sequence specific binding sites.

Four or five slender jointed digits in humans and primates, attached to each HAND.

Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.

Proteins which bind to DNA. The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases.

Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process.

The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.

Inorganic compounds that contain zinc as an integral part of the molecule.

A compound given in the treatment of conditions associated with zinc deficiency such as acrodermatitis enteropathica. Externally, zinc sulfate is used as an astringent in lotions and eye drops. (Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Englewood, CO, 1995)

A family of zinc finger transcription factors that share homology with Kruppel protein, Drosophila. They contain a highly conserved seven amino acid spacer sequence in between their ZINC FINGER MOTIFS.

The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.

A mild astringent and topical protectant with some antiseptic action. It is also used in bandages, pastes, ointments, dental cements, and as a sunblock.

Proteins which maintain the transcriptional quiescence of specific GENES or OPERONS. Classical repressor proteins are DNA-binding proteins that are normally bound to the OPERATOR REGION of an operon, or the ENHANCER SEQUENCES of a gene until a signal occurs that causes their release.

The parts of a macromolecule that directly participate in its specific combination with another molecule.

The degree of similarity between sequences of amino acids. This information is useful for the analyzing genetic relatedness of proteins and species.

Stable zinc atoms that have the same atomic number as the element zinc, but differ in atomic weight. Zn-66-68, and 70 are stable zinc isotopes.

The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.

One of several general transcription factors that are specific for RNA POLYMERASE III. It is a zinc finger (ZINC FINGERS) protein and is required for transcription of 5S ribosomal genes.

A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).

The level of protein structure in which combinations of secondary protein structures (alpha helices, beta sheets, loop regions, and motifs) pack together to form folded shapes called domains. Disulfide bridges between cysteines in two different parts of the polypeptide chain along with other interactions between the chains play a role in the formation and stabilization of tertiary structure. Small proteins usually consist of only one domain but larger proteins may contain a number of domains connected by segments of polypeptide chain which lack regular secondary structure.

A salt produced by the reaction of zinc oxide with acetic acid and used as an astringent, styptic, and emetic.

The insertion of recombinant DNA molecules from prokaryotic and/or eukaryotic sources into a replicating vehicle, such as a plasmid or virus vector, and the introduction of the resultant hybrid molecules into recipient cells without altering the viability of those cells.

A zinc-binding domain defined by the sequence Cysteine-X2-Cysteine-X(9-39)-Cysteine-X(l-3)-His-X(2-3)-Cysteine-X2-Cysteine -X(4-48)-Cysteine-X2-Cysteine, where X is any amino acid. The RING finger motif binds two atoms of zinc, with each zinc atom ligated tetrahedrally by either four cysteines or three cysteines and a histidine. The motif also forms into a unitary structure with a central cross-brace region and is found in many proteins that are involved in protein-protein interactions. The acronym RING stands for Really Interesting New Gene.

Proteins that have one or more tightly bound metal ions forming part of their structure. (Dorland, 28th ed)

DNA sequences which are recognized (directly or indirectly) and bound by a DNA-dependent RNA polymerase during the initiation of transcription. Highly conserved sequences within the promoter include the Pribnow box in bacteria and the TATA BOX in eukaryotes.

The arrangement of two or more amino acid or base sequences from an organism or organisms in such a way as to align areas of the sequences sharing common properties. The degree of relatedness or homology between the sequences is predicted computationally or statistically based on weights assigned to the elements aligned between the sequences. This in turn can serve as a potential indicator of the genetic relatedness between the organisms.

Proteins found in the nucleus of a cell. Do not confuse with NUCLEOPROTEINS which are proteins conjugated with nucleic acids, that are not necessarily present in the nucleus.

A metallic element of atomic number 30 and atomic weight 65.38. It is a necessary trace element in the diet, forming an essential part of many enzymes, and playing an important role in protein synthesis and in cell division. Zinc deficiency is associated with ANEMIA, short stature, HYPOGONADISM, impaired WOUND HEALING, and geophagia. It is known by the symbol Zn.

Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.

Recombinant proteins produced by the GENETIC TRANSLATION of fused genes formed by the combination of NUCLEIC ACID REGULATORY SEQUENCES of one or more genes with the protein coding sequences of one or more genes.

Bones that make up the SKELETON of the FINGERS, consisting of two for the THUMB, and three for each of the other fingers.

A theoretical representative nucleotide or amino acid sequence in which each nucleotide or amino acid is the one which occurs most frequently at that site in the different sequences which occur in nature. The phrase also refers to an actual sequence which approximates the theoretical consensus. A known CONSERVED SEQUENCE set is represented by a consensus sequence. Commonly observed supersecondary protein structures (AMINO ACID MOTIFS) are often formed by conserved sequences.

Established cell cultures that have the potential to propagate indefinitely.

Single-stranded complementary DNA synthesized from an RNA template by the action of RNA-dependent DNA polymerase. cDNA (i.e., complementary DNA, not circular DNA, not C-DNA) is used in a variety of molecular cloning experiments as well as serving as a specific hybridization probe.

The biosynthesis of RNA carried out on a template of DNA. The biosynthesis of DNA from an RNA template is called REVERSE TRANSCRIPTION.

A painful disability in the hand affecting the finger or thumb. It is caused by mechanical impingement of the digital flexor tendons as they pass through a narrowed retinacular pulley at the level of the metacarpal head. Thickening of the sheath and fibrocartilaginous metaplasia can occur, and nodules can form. (From Green's Operative Hand Surgery, 5th ed, p2137-58).

An early growth response transcription factor that has been implicated in regulation of CELL PROLIFERATION and APOPTOSIS.

Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.

Transport proteins that carry specific substances in the blood or across cell membranes.

RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.

Screening techniques first developed in yeast to identify genes encoding interacting proteins. Variations are used to evaluate interplay between proteins and other molecules. Two-hybrid techniques refer to analysis for protein-protein interactions, one-hybrid for DNA-protein interactions, three-hybrid interactions for RNA-protein interactions or ligand-based interactions. Reverse n-hybrid techniques refer to analysis for mutations or other small molecules that dissociate known interactions.

A sequence of amino acids in a polypeptide or of nucleotides in DNA or RNA that is similar across multiple species. A known set of conserved sequences is represented by a CONSENSUS SEQUENCE. AMINO ACID MOTIFS are often composed of conserved sequences.

A ZINC FINGER MOTIF containing transcription factor that was originally identified as one of the IMMEDIATE-EARLY PROTEINS. It shuttles between the CYTOPLASM and the CELL NUCLEUS and is involved in destabilization of mRNAs for TUMOR NECROSIS FACTOR-ALPHA.

Procedures by which protein structure and function are changed or created in vitro by altering existing or synthesizing new structural genes that direct the synthesis of proteins with sought-after properties. Such procedures may include the design of MOLECULAR MODELS of proteins using COMPUTER GRAPHICS or other molecular modeling techniques; site-specific mutagenesis (MUTAGENESIS, SITE-SPECIFIC) of existing genes; and DIRECTED MOLECULAR EVOLUTION techniques to create new genes.

Constituent of the 50S subunit of prokaryotic ribosomes containing about 120 nucleotides and 34 proteins. It is also a constituent of the 60S subunit of eukaryotic ribosomes. 5S rRNA is involved in initiation of polypeptide synthesis.

Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action during the developmental stages of an organism.

Processes that stimulate the GENETIC TRANSCRIPTION of a gene or set of genes.

A low-molecular-weight (approx. 10 kD) protein occurring in the cytoplasm of kidney cortex and liver. It is rich in cysteinyl residues and contains no aromatic amino acids. Metallothionein shows high affinity for bivalent heavy metals.

Diffusible gene products that act on homologous or heterologous molecules of viral or cellular DNA to regulate the expression of proteins.

The uptake of naked or purified DNA by CELLS, usually meaning the process as it occurs in eukaryotic cells. It is analogous to bacterial transformation (TRANSFORMATION, BACTERIAL) and both are routinely employed in GENE TRANSFER TECHNIQUES.

A transcription factor that plays a role as a key regulator of HEMATOPOIESIS. Aberrant Ikaros expression has been associated with LYMPHOBLASTIC LEUKEMIA.

Isoforms encoded by the WT1 Wilms tumor suppressor gene (GENES, WILMS TUMOR) and produced by alternative splicings. They are zinc finger-containing transcription factors involved in both transactivation and repression, and are critical for normal development and function of the urogenital tract.

Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures.

Genetically engineered MUTAGENESIS at a specific site in the DNA molecule that introduces a base substitution, or an insertion or deletion.

Proteins that originate from insect species belonging to the genus DROSOPHILA. The proteins from the most intensely studied species of Drosophila, DROSOPHILA MELANOGASTER, are the subject of much interest in the area of MORPHOGENESIS and development.

Within a eukaryotic cell, a membrane-limited body which contains chromosomes and one or more nucleoli (CELL NUCLEOLUS). The nuclear membrane consists of a double unit-type membrane which is perforated by a number of pores; the outermost membrane is continuous with the ENDOPLASMIC RETICULUM. A cell may contain more than one nucleus. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)

Commonly observed structural components of proteins formed by simple combinations of adjacent secondary structures. A commonly observed structure may be composed of a CONSERVED SEQUENCE which can be represented by a CONSENSUS SEQUENCE.

Short sequences (generally about 10 base pairs) of DNA that are complementary to sequences of messenger RNA and allow reverse transcriptases to start copying the adjacent sequences of mRNA. Primers are used extensively in genetic and molecular biology techniques.

Proteins prepared by recombinant DNA technology.

A group of transcription factors that were originally described as being specific to ERYTHROID CELLS.

A thiol-containing non-essential amino acid that is oxidized to form CYSTINE.

CELL LINES derived from the CV-1 cell line by transformation with a replication origin defective mutant of SV40 VIRUS, which codes for wild type large T antigen (ANTIGENS, POLYOMAVIRUS TRANSFORMING). They are used for transfection and cloning. (The CV-1 cell line was derived from the kidney of an adult male African green monkey (CERCOPITHECUS AETHIOPS).)

Proteins encoded by homeobox genes (GENES, HOMEOBOX) that exhibit structural similarity to certain prokaryotic and eukaryotic DNA-binding proteins. Homeodomain proteins are involved in the control of gene expression during morphogenesis and development (GENE EXPRESSION REGULATION, DEVELOPMENTAL).

The distal part of the arm beyond the wrist in humans and primates, that includes the palm, fingers, and thumb.

A GATA transcription factor that is expressed in the MYOCARDIUM of developing heart and has been implicated in the differentiation of CARDIAC MYOCYTES. GATA4 is activated by PHOSPHORYLATION and regulates transcription of cardiac-specific genes.

Extrachromosomal, usually CIRCULAR DNA molecules that are self-replicating and transferable from one organism to another. They are found in a variety of bacterial, archaeal, fungal, algal, and plant species. They are used in GENETIC ENGINEERING as CLONING VECTORS.

Proteins found in any species of fungus.

A large collection of DNA fragments cloned (CLONING, MOLECULAR) from a given organism, tissue, organ, or cell type. It may contain complete genomic sequences (GENOMIC LIBRARY) or complementary DNA sequences, the latter being formed from messenger RNA and lacking intron sequences.

Genes whose expression is easily detectable and therefore used to study promoter activity at many positions in a target genome. In recombinant DNA technology, these genes may be attached to a promoter region of interest.

The first continuously cultured human malignant CELL LINE, derived from the cervical carcinoma of Henrietta Lacks. These cells are used for VIRUS CULTIVATION and antitumor drug screening assays.

Proteins that bind to RNA molecules. Included here are RIBONUCLEOPROTEINS and other proteins whose function is to bind specifically to RNA.

Proteins obtained from various species of Xenopus. Included here are proteins from the African clawed frog (XENOPUS LAEVIS). Many of these proteins have been the subject of scientific investigations in the area of MORPHOGENESIS and development.

Proteins encoded by the GAG GENE of the HUMAN IMMUNODEFICIENCY VIRUS.

The act, process, or result of passing from one place or position to another. It differs from LOCOMOTION in that locomotion is restricted to the passing of the whole body from one place to another, while movement encompasses both locomotion but also a change of the position of the whole body or any of its parts. Movement may be used with reference to humans, vertebrate and invertebrate animals, and microorganisms. Differentiate also from MOTOR ACTIVITY, movement associated with behavior.

The characteristic 3-dimensional shape of a protein, including the secondary, supersecondary (motifs), tertiary (domains) and quaternary structure of the peptide chain. PROTEIN STRUCTURE, QUATERNARY describes the conformation assumed by multimeric proteins (aggregates of more than one polypeptide chain).

A genus of small, two-winged flies containing approximately 900 described species. These organisms are the most extensively studied of all genera from the standpoint of genetics and cytology.

A GATA transcription factor that is specifically expressed in hematopoietic lineages and plays an important role in the CELL DIFFERENTIATION of ERYTHROID CELLS and MEGAKARYOCYTES.

Genes at loci that are involved in the development of WILMS TUMOR. Included are human WT1 at 11p13 and human WT2 (MTACR1) at 11p15.

Promoter-specific RNA polymerase II transcription factor that binds to the GC box, one of the upstream promoter elements, in mammalian cells. The binding of Sp1 is necessary for the initiation of transcription in the promoters of a variety of cellular and viral GENES.

Proteins that are coded by immediate-early genes, in the absence of de novo protein synthesis. The term was originally used exclusively for viral regulatory proteins that were synthesized just after viral integration into the host cell. It is also used to describe cellular proteins which are synthesized immediately after the resting cell is stimulated by extracellular signals.

Proteins obtained from the species SACCHAROMYCES CEREVISIAE. The function of specific proteins from this organism are the subject of intense scientific interest and have been used to derive basic understanding of the functioning similar proteins in higher eukaryotes.

An early growth response transcription factor that controls the formation of the MYELIN SHEATH around peripheral AXONS by SCHWANN CELLS. Mutations in EGR2 transcription factor have been associated with HEREDITARY MOTOR AND SENSORY NEUROPATHIES such as CHARCOT-MARIE-TOOTH DISEASE.

The integration of exogenous DNA into the genome of an organism at sites where its expression can be suitably controlled. This integration occurs as a result of homologous recombination.

A continuing periodic change in displacement with respect to a fixed reference. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)

The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.

Force exerted when gripping or grasping.

Deletion of sequences of nucleic acids from the genetic material of an individual.

An electrophoretic technique for assaying the binding of one compound to another. Typically one compound is labeled to follow its mobility during electrophoresis. If the labeled compound is bound by the other compound, then the mobility of the labeled compound through the electrophoretic medium will be retarded.

A technique that localizes specific nucleic acid sequences within intact chromosomes, eukaryotic cells, or bacterial cells through the use of specific nucleic acid-labeled probes.

A diverse class of enzymes that interact with UBIQUITIN-CONJUGATING ENZYMES and ubiquitination-specific protein substrates. Each member of this enzyme group has its own distinct specificity for a substrate and ubiquitin-conjugating enzyme. Ubiquitin-protein ligases exist as both monomeric proteins multiprotein complexes.

A family of transcription factors that are induced by GROWTH FACTORS and contain a highly conserved DNA-binding domain composed of three ZINC FINGER MOTIFS.

Use of restriction endonucleases to analyze and generate a physical map of genomes, genes, or other segments of DNA.

A species of the genus SACCHAROMYCES, family Saccharomycetaceae, order Saccharomycetales, known as "baker's" or "brewer's" yeast. The dried form is used as a dietary supplement.

The first digit on the radial side of the hand which in humans lies opposite the other four.

The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.

Process of generating a genetic MUTATION. It may occur spontaneously or be induced by MUTAGENS.

The sequential correspondence of nucleotides in one nucleic acid molecule with those of another nucleic acid molecule. Sequence homology is an indication of the genetic relatedness of different organisms and gene function.

A set of genes descended by duplication and variation from some ancestral gene. Such genes may be clustered together on the same chromosome or dispersed on different chromosomes. Examples of multigene families include those that encode the hemoglobins, immunoglobulins, histocompatibility antigens, actins, tubulins, keratins, collagens, heat shock proteins, salivary glue proteins, chorion proteins, cuticle proteins, yolk proteins, and phaseolins, as well as histones, ribosomal RNA, and transfer RNA genes. The latter three are examples of reiterated genes, where hundreds of identical genes are present in a tandem array. (King & Stanfield, A Dictionary of Genetics, 4th ed)

An idiopathic vascular disorder characterized by bilateral Raynaud phenomenon, the abrupt onset of digital paleness or CYANOSIS in response to cold exposure or stress.

Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.

A Drosophila doublesex-related gene, terra, is involved in somitogenesis in vertebrates. (1/4650)

The Drosophila doublesex (dsx) gene encodes a transcription factor that mediates sex determination. We describe the characterization of a novel zebrafish zinc-finger gene, terra, which contains a DNA binding domain similar to that of the Drosophila dsx gene. However, unlike dsx, terra is transiently expressed in the presomitic mesoderm and newly formed somites. Expression of terra in presomitic mesoderm is restricted to cells that lack expression of MyoD. In vivo, terra expression is reduced by hedgehog but enhanced by BMP signals. Overexpression of terra induces rapid apoptosis both in vitro and in vivo, suggesting that a tight regulation of terra expression is required during embryogenesis. Terra has both human and mouse homologs and is specifically expressed in mouse somites. Taken together, our findings suggest that terra is a highly conserved protein that plays specific roles in early somitogenesis of vertebrates. (+info)

ETO-2, a new member of the ETO-family of nuclear proteins. (2/4650)

The t(8;21) is associated with 12-15% of acute myelogenous leukemias of the M2 subtype. The translocation results in the fusion of two genes, AML1 (CBFA2) on chromosome 21 and ETO (MTG8) on chromosome 8. AML1 encodes a DNA binding factor; the ETO protein product is less well characterized, but is thought to be a transcription factor. Here we describe the isolation and characterization of ETO-2, a murine cDNA that encodes a new member of the ETO family of proteins. ETO-2 is 75% identical to murine ETO and shares very high sequence identities over four regions of the protein with ETO (domain I-III and zinc-finger). Northern analysis identifies ETO-2 transcripts in many of the murine tissues analysed and in the developing mouse embryo. ETO-2 is also expressed in myeloid and erythroid cell lines. We confirmed the nuclear localization of ETO-2 and demonstrated that domain III and the zinc-finger region are not required for nuclear localization. We further showed that a region within ETO, containing domain II, mediates dimerization among family members. This region is conserved in the oncoprotein AML-1/ETO. The recent identification of another ETO-like protein, myeloid translocation gene-related protein 1, together with the data presented here, demonstrates that at least three ETO proteins exist with the potential to form dimers in the cell nucleus. (+info)

Nrg1 is a transcriptional repressor for glucose repression of STA1 gene expression in Saccharomyces cerevisiae. (3/4650)

Expression of genes encoding starch-degrading enzymes is regulated by glucose repression in the yeast Saccharomyces cerevisiae. We have identified a transcriptional repressor, Nrg1, in a genetic screen designed to reveal negative factors involved in the expression of STA1, which encodes a glucoamylase. The NRG1 gene encodes a 25-kDa C2H2 zinc finger protein which specifically binds to two regions in the upstream activation sequence of the STA1 gene, as judged by gel retardation and DNase I footprinting analyses. Disruption of the NRG1 gene causes a fivefold increase in the level of the STA1 transcript in the presence of glucose. The expression of NRG1 itself is inhibited in the absence of glucose. DNA-bound LexA-Nrg1 represses transcription of a target gene 10.7-fold in a glucose-dependent manner, and this repression is abolished in both ssn6 and tup1 mutants. Two-hybrid and glutathione S-transferase pull-down experiments show an interaction of Nrg1 with Ssn6 both in vivo and in vitro. These findings indicate that Nrg1 acts as a DNA-binding repressor and mediates glucose repression of the STA1 gene expression by recruiting the Ssn6-Tup1 complex. (+info)

The mouse Aire gene: comparative genomic sequencing, gene organization, and expression. (4/4650)

Mutations in the human AIRE gene (hAIRE) result in the development of an autoimmune disease named APECED (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy; OMIM 240300). Previously, we have cloned hAIRE and shown that it codes for a putative transcription-associated factor. Here we report the cloning and characterization of Aire, the murine ortholog of hAIRE. Comparative genomic sequencing revealed that the structure of the AIRE gene is highly conserved between human and mouse. The conceptual proteins share 73% homology and feature the same typical functional domains in both species. RT-PCR analysis detected three splice variant isoforms in various mouse tissues, and interestingly one isoform was conserved in human, suggesting potential biological relevance of this product. In situ hybridization on mouse and human histological sections showed that AIRE expression pattern was mainly restricted to a few cells in the thymus, calling for a tissue-specific function of the gene product. (+info)

Identification and characterization of a zinc finger gene (ZNF213) from 16p13.3. (5/4650)

During our search for the familial Mediterranean fever (FMF) gene, we identified by cDNA selection a 1.2 kb cDNA fragment representing a novel human gene that is expressed in a wide variety of tissues. This gene spans approx. 8.0 kb genomic DNA and has seven exons. Its 3' untranslated region contains a long tandem repeat that gives rise to a polymorphism with two alleles of approx. 1.1 kb and 1.0 kb, with the 1.1 kb allele in strong linkage disequilibrium with FMF in patients of different ethnic backgrounds. However, both genetic and mutational analyses have excluded this gene as the one responsible for FMF. The predicted 424 amino acid protein, designated ZNF213, contains three C2H2 zinc fingers, a Kruppel associated A box and a leucine rich motif (LeR domain/SCAN box), strongly suggestive of a transcription factor. (+info)

Leukemia translocation protein PLZF inhibits cell growth and expression of cyclin A. (6/4650)

The PLZF gene was identified by its fusion with the RARalpha locus in a therapy resistant form of acute promyelocytic leukemia (APL) associated with the t(11;17)(q23;q21) translocation. Here we describe PLZF as a negative regulator of cell cycle progression ultimately leading to growth suppression. PLZF can bind and repress the cyclin A2 promoter while expression of cyclin A2 reverts the growth suppressed phenotype of myeloid cells expressing PLZF. In contrast RARalpha-PLZF, a fusion protein generated in t(11;17)(q23;q21)-APL activates cyclin A2 transcription and allows expression of cyclin A in anchorage-deprived NIH3T3 cells. Therefore, cyclin A2 is a candidate target gene for PLZF and inhibition of cyclin A expression may contribute to the growth suppressive properties of PLZF. Deregulation of cyclin A2 by RARalpha-PLZF may represent an oncogenic mechanism of this chimeric protein and contribute to the aggressive clinical phenotype of t(11;17)(q23;q21)-associated APL. (+info)

RFLAT-1: a new zinc finger transcription factor that activates RANTES gene expression in T lymphocytes. (7/4650)

RANTES (Regulated upon Activation, Normal T cell Expressed and Secreted) is a chemoattractant cytokine (chemokine) important in the generation of inflammatory infiltrate and human immunodeficiency virus entry into immune cells. RANTES is expressed late (3-5 days) after activation in T lymphocytes. Using expression cloning, we identified the first "late" T lymphocyte associated transcription factor and named it "RANTES Factor of Late Activated T Lymphocytes-1" (RFLAT-1). RFLAT-1 is a novel, phosphorylated, zinc finger transcription factor that is expressed in T cells 3 days after activation, coincident with RANTES expression. While Rel proteins play the dominant role in RANTES gene expression in fibroblasts, RFLAT-1 is a strong transactivator for RANTES in T cells. (+info)

Mapping the functional domains of BRCA1. Interaction of the ring finger domains of BRCA1 and BARD1. (8/4650)

Breast cancer 1 (BRCA1) and BRCA1-associated RING domain 1 (BARD1) are multidomain proteins that interact in vivo via their N-terminal RING finger motif regions. To characterize functional aspects of the BRCA1/BARD1 interaction, we have defined the structural domains required for the interaction, as well as their oligomerization state, relative stability, and possible nucleic acid binding activity. We have found that the RING finger motifs do not themselves constitute stable structural domains but are instead part of larger domains comprising residues 1-109 of BRCA1 and residues 26-119 of BARD1. These domains exist as homodimers and preferentially form a stable heterodimer. Shorter BRCA1 RING finger constructs do not interact with BARD1 or with longer BRCA1 constructs, indicating that the heterodimeric and homodimer interactions are mediated by regions outside the canonical RING finger motif. Nucleic acid binding is a generally proposed function of RING finger domains. We show that neither the homodimers nor the heterodimer displays affinity for nucleic acids, indicating that the proposed roles of BRCA1 and BARD1 in DNA repair and/or transcriptional activation must be mediated either by other regions of the proteins or by additional cofactors. (+info)

In molecular biology the MIZ-type zinc finger domain is a zinc finger-containing protein with homology to the yeast protein, ... Wu L, Wu H, Ma L, Sangiorgi F, Wu N, Bell JR, Lyons GE, Maxson R (July 1997). "Miz1, a novel zinc finger transcription factor ... The name MIZ is derived from Msx-interacting-zinc finger. The crystal structure of S. cerevisiae sumo e3 ligase siz1 containing ...

https://en.wikipedia.org/wiki/MIZ_zinc_finger

In molecular biology the MYND-type zinc finger domain is a conserved protein domain. The MYND domain (myeloid, Nervy, and DEAF- ... ETO has been shown to be a co-repressor recruited by the promyelocytic leukemia zinc finger (PLZF) protein. A divergent MYND ... associated acute myeloid leukemia is a corepressor for the promyelocytic leukemia zinc finger protein". Mol. Cell. Biol. 20 (6 ... arranged with an invariant spacing to form a potential zinc-binding motif. Mutating conserved cysteine residues in the DEAF-1 ...

https://en.wikipedia.org/wiki/MYND_zinc_finger

"Entrez Gene: Zinc finger protein 84". Retrieved 2016-02-16. v t e v t e (Genes on human chromosome 12, All stub articles, Human ... Zinc finger protein 84 is a protein that in humans is encoded by the ZNF84 gene. GRCh38: Ensembl release 89: ENSG00000198040 - ...

https://en.wikipedia.org/wiki/Zinc_finger_protein_84

... is a protein that in humans is encoded by the ZNF263 gene. GRCh38: Ensembl release 89: ENSG00000006194 ... "Entrez Gene: Zinc finger protein 263". Retrieved 2017-01-30. v t e (Articles with short description, Short description matches ...

https://en.wikipedia.org/wiki/Zinc_finger_protein_263

... is a protein that in humans is encoded by the ZFHX2 gene. It has been implicated in pain insensitivity. ... "Entrez Gene: Zinc finger homeobox 2". Habib AM, Matsuyama A, Okorokov AL, Santana-Varela S, Bras JT, Aloisi AM, et al. ( ...

https://en.wikipedia.org/wiki/Zinc_finger_homeobox_2

"Entrez Gene: Zinc finger protein 585B". Retrieved 2016-03-22. v t e v t e (Articles with short description, Short description ... Zinc finger protein 585B is a protein that in humans is encoded by the ZNF585B gene. GRCh38: Ensembl release 89: ...

https://en.wikipedia.org/wiki/Zinc_finger_protein_585b

... is a protein that in humans is encoded by the ZNF506 gene. GRCh38: Ensembl release 89: ENSG00000081665 ... "Entrez Gene: Zinc finger protein 506". Retrieved 2016-02-01. v t e (Articles with short description, Short description matches ...

https://en.wikipedia.org/wiki/Zinc_finger_protein_506

The FPG IleRS zinc finger domain represents a zinc finger domain found at the C-terminal in both DNA glycosylase/AP lyase ... "Mutation of the carboxy terminal zinc finger of E. coli isoleucyl-tRNA synthetase alters zinc binding and aminoacylation ... An Fpg-type zinc finger is also found at the C terminus of isoleucyl tRNA synthetase (EC). This enzyme catalyses the attachment ... The two DNA-binding motifs (a zinc finger and the helix-two-turns-helix motifs) suggest that the oxidized base is flipped out ...

https://en.wikipedia.org/wiki/FPG_IleRS_zinc_finger

... is a protein that in humans is encoded by the ZNF749 gene. GRCh38: Ensembl release 89: ENSG00000186230 ... "Entrez Gene: Zinc finger protein 749". Retrieved 2016-07-18. v t e (Articles with short description, Short description matches ... Wikidata, Genes on human chromosome 19, All stub articles, Human chromosome 19 gene stubs, Zinc finger proteins). ...

https://en.wikipedia.org/wiki/Zinc_finger_protein_749

... is a protein that in humans is encoded by the ZNF696 gene. GRCh38: Ensembl release 89: ENSG00000185730 ... "Entrez Gene: Zinc finger protein 696". Retrieved 2016-01-19. v t e (Articles with short description, Short description matches ...

https://en.wikipedia.org/wiki/Zinc_finger_protein_696

... is a protein that in humans is encoded by the ZNF684 gene. GRCh38: Ensembl release 89: ENSG00000117010 ... "Entrez Gene: Zinc finger protein 684". Retrieved 2016-04-11. v t e (Articles with short description, Short description matches ...

https://en.wikipedia.org/wiki/Zinc_finger_protein_684

... is a protein that in humans is encoded by the ZNF414 gene. GRCh38: Ensembl release 89: ENSG00000133250 ... "Entrez Gene: Zinc finger protein 414". Retrieved 2016-08-22. v t e (Articles with short description, Short description matches ...

https://en.wikipedia.org/wiki/Zinc_finger_protein_414

... is a protein that in humans is encoded by the ZNF236 gene. GRCh38: Ensembl release 89: ENSG00000130856 ... "Entrez Gene: Zinc finger protein 236". Holmes DI, Abdel Wahab N, Mason RM (September 1997). "Identification of glucose- ... "The Kruppel-like zinc-finger gene ZNF236 is alternatively spliced and excluded as susceptibility gene for diabetic nephropathy ... a glucose-regulated Kruppel-like zinc-finger gene mapping to human chromosome 18q22-q23". Genomics. 60 (1): 105-9. doi:10.1006/ ...

https://en.wikipedia.org/wiki/Zinc_finger_protein_236

In molecular biology, the Btk-type zinc finger or Btk motif (BM) is a conserved zinc-binding motif containing conserved ... The Btk motif contains a conserved His and three Cys residues that form a zinc finger (although these differ from known zinc ... Proteins known to contain a Btk-type zinc finger include: Mammalian Bruton's tyrosine kinase (Btk), a protein tyrosine kinase ... The crystal structures of Btk show that the Btk-type zinc finger has a globular core, formed by a long loop which is held ...

https://en.wikipedia.org/wiki/Btk-type_zinc_finger

... is a protein that in humans is encoded by the ZNF608 gene. GRCh38: Ensembl release 89: ENSG00000168916 ... "Entrez Gene: Zinc finger protein 608". Speliotes EK, Willer CJ, Berndt SI, Monda KL, Thorleifsson G, Jackson AU, et al. ( ...

https://en.wikipedia.org/wiki/Zinc_finger_protein_608

... is a protein that in humans is encoded by the ZNF439 gene. "Human PubMed Reference:". National Center ... "Entrez Gene: Zinc finger protein 439". Retrieved 2016-03-21. v t e (Articles with short description, Short description matches ...

https://en.wikipedia.org/wiki/Zinc_finger_protein_439

... is a protein that in humans is encoded by the ZNF134 gene. GRCh38: Ensembl release 89: ENSG00000213762 ... "Entrez Gene: Zinc finger protein 134". Retrieved 2016-01-19. v t e (Articles with short description, Short description matches ...

https://en.wikipedia.org/wiki/Zinc_finger_protein_134

... is a protein that in humans is encoded by the ZNF780A gene. ENSG00000280568 GRCh38: Ensembl release 89 ... "Entrez Gene: Zinc finger protein 780A". Retrieved 2017-04-14. v t e (Articles with short description, Short description matches ...

https://en.wikipedia.org/wiki/Zinc_finger_protein_780a

... is a protein that in humans is encoded by the ZNF541 gene. GRCh38: Ensembl release 89: ENSG00000118156 ... "Entrez Gene: Zinc finger protein 541". Retrieved 2016-02-11. v t e (Articles with short description, Short description matches ...

https://en.wikipedia.org/wiki/Zinc_finger_protein_541

... is a protein that in humans is encoded by the ZNF334 gene. This gene encodes a member of the C2H2 zinc ... "Entrez Gene: Zinc finger protein 334". Retrieved 2016-03-10. Henc I, Soroczyńska-Cybula M, Bryl E, Witkowski JM (2015). "The in ... The encoded protein contains a Krueppel-associated box, fourteen C2H2 zinc finger domains, and four C2H2-type/integrase DNA- ... vitro modulatory effect of TNFα on the mRNA expression and protein levels of zinc finger protein ZNF334 in CD4(+) lymphocytes ...

https://en.wikipedia.org/wiki/Zinc_finger_protein_334

"Entrez Gene: Zinc finger protein 716". Retrieved 2016-02-24. v t e v t e (Genes on human chromosome 7, Human proteins, All stub ... Zinc finger protein 716 is a protein that in humans is encoded by the ZNF716 gene. GRCh38: Ensembl release 89: ENSG00000182111 ...

https://en.wikipedia.org/wiki/Zinc_finger_protein_716

"Entrez Gene: Zinc finger protein 286A". Retrieved 2017-04-14. v t e (Genes on human chromosome, All stub articles, Human ... Zinc finger protein 286A is a protein encoded in humans by the ZNF286A gene. GRCm38: Ensembl release 89: ENSMUSG00000047342 - ...

https://en.wikipedia.org/wiki/Zinc_finger_protein_286a

... is a protein that in humans is encoded by the ZNF780B gene. ENSG00000281601 GRCh38: Ensembl release 89 ... "Entrez Gene: Zinc finger protein 780B". Retrieved 2016-04-21. v t e (Articles with short description, Short description matches ...

https://en.wikipedia.org/wiki/Zinc_finger_protein_780b

... is a protein that in humans is encoded by the ZNF26 gene. GRCh38: Ensembl release 89: ENSG00000198393 - ... "Entrez Gene: Zinc finger protein 26". Retrieved 2016-02-01. v t e (Genes on human chromosome 12, All stub articles, Human ...

https://en.wikipedia.org/wiki/Zinc_finger_protein_26

"Entrez Gene: ZFP69 zinc finger protein". Retrieved 2016-02-17. v t e v t e (Articles with short description, Short description ... ZFP69 zinc finger protein is a protein that in humans is encoded by the ZFP69 gene. GRCh38: Ensembl release 89: ENSG00000187815 ...

https://en.wikipedia.org/wiki/Zfp69_zinc_finger_protein

"Entrez Gene: Zinc finger protein 577". Retrieved 2016-03-04. Sehrawat B, Sridharan M, Ghosh S, Robson P, Cass CE, Mackey JR, ... Zinc finger protein 577 is a protein that in humans is encoded by the ZNF577 gene. GRCh38: Ensembl release 89: ENSG00000161551 ...

https://en.wikipedia.org/wiki/Zinc_finger_protein_577

... is a protein that in humans is encoded by the ZNF117 gene. GRCh38: Ensembl release 89: ENSG00000152926 ... "Entrez Gene: Zinc finger protein 117". Retrieved 2016-03-22. Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized ...

https://en.wikipedia.org/wiki/Zinc_finger_protein_117

"Entrez Gene: Zinc finger protein 394". Retrieved 2016-03-02. Huang C, Wang Y, Li D, Li Y, Luo J, Yuan W, Ou Y, Zhu C, Zhang Y, ... Zinc finger protein 394 is a protein that in humans is encoded by the ZNF394 gene. GRCh38: Ensembl release 89: ENSG00000160908 ... Wang Z, Liu M, Wu X (2004). "Inhibition of transcriptional activities of AP-1 and c-Jun by a new zinc finger protein ZNF394". ...

https://en.wikipedia.org/wiki/Zinc_finger_protein_394

... is a protein that in humans is encoded by the ZNF516 gene. Zinc-finger proteins bind nucleic acids and ... This gene encodes a zinc-finger protein, and belongs to the Krüppel C2H2-type zinc-finger protein family. It may be involved in ... "Entrez Gene: Zinc finger protein 516". Shaffer JR, Feingold E, Wang X, Lee M, Tcuenco K, Weeks DE, Weyant RJ, Crout R, McNeil ...

https://en.wikipedia.org/wiki/Zinc_finger_protein_516

... is a protein that in humans is encoded by the ZNF786 gene. GRCh38: Ensembl release 89: ENSG00000197362 ... "Entrez Gene: Zinc finger protein 786". Retrieved 2016-03-22. v t e (Genes on human chromosome 7, Human proteins, All stub ...

https://en.wikipedia.org/wiki/Zinc_finger_protein_786

Gommans WM, Haisma HJ, Rots MG (December 2005). "Engineering zinc finger protein transcription factors: the therapeutic ...

https://en.wikipedia.org/wiki/Phage_display

The signature of the C2H2-type zinc finger domain is: C-x(2,4)-C-x(3)-[LIVMFYWC]-x(8)-H-x(3,5)-H A matrix of numbers containing ...

https://en.wikipedia.org/wiki/Sequence_motif

... and zinc cames (instead of the traditional lead) for his leadlight windows, and he famously used Pyrex glass tubing as a major ... All are in my fingers to this day... " In 1881, soon after Wright turned 14, his parents separated. In 1884, his father sued ...

https://en.wikipedia.org/wiki/Frank_Lloyd_Wright

Zinc finger E-box-binding homeobox 2) and PRKD3 (Serine/threonine-protein kinase D3). Neault et al. recently identified miR-137 ...

https://en.wikipedia.org/wiki/MiR-137

Towards the latter part of the 19th and early 20th century, some were cast with zinc, commonly referred to as White Bronze. A ... Often, the opposite arm is raised with the index finger of the hand pointing towards the sky. This symbolizes the pathway to ...

https://en.wikipedia.org/wiki/Statue_of_Hope

ZNF598 is a zinc finger protein and the value is .13. It plays a key role in ribosome quality control. The predicted structures ...

https://en.wikipedia.org/wiki/FAM178B

... is a protein that in humans is encoded by the ZNF695 gene. ZNF692 GRCh38: Ensembl release 89: ... "Entrez Gene: Zinc finger protein 695". Retrieved 2016-02-29. Takahashi T, Yamahsita S, Matsuda Y, Kishino T, Nakajima T, ... "Splice variants of zinc finger protein 695 mRNA associated to ovarian cancer". J Ovarian Res. 6 (1): 61. doi:10.1186/1757-2215- ...

https://en.wikipedia.org/wiki/Zinc_finger_protein_695

... zinc fingers'. In its regulatory role, zinc is involved in the regulation of nucleoproteins and the activity of various ... Zinc deficiency is defined either as insufficient zinc to meet the needs of the body, or as a serum zinc level below the normal ... Even with zinc-efficient varieties, zinc fertilizers are needed when the available zinc in the topsoil becomes depleted. Plant ... As biosystems are unable to store zinc, regular intake is necessary. Excessively low zinc intake can lead to zinc deficiency, ...

https://en.wikipedia.org/wiki/Zinc_deficiency

... is a protein that in humans is encoded by the ZNF275 gene. This gene encodes a zinc finger protein that ... "Entrez Gene: Zinc finger protein 275". Retrieved 2016-05-31. This article incorporates text from the United States National ...

https://en.wikipedia.org/wiki/Zinc_finger_protein_275

Such elements include germanium, zinc, platinum, silicon, and boron. Recent examples of these alloys include argentium, ... when etiquette dictated no food should be touched with one's fingers. Serving pieces were often elaborately decorated and ...

https://en.wikipedia.org/wiki/Sterling_silver

Mol Cell Biol 10:3562-3568 (1990) Novel zinc finger gene implicated as myc collaborator by retrovirally accelerated lymphoma ...

https://en.wikipedia.org/wiki/Peter_Klinken

YY1 is a zinc-finger protein that acts as a transcriptional repressor for a wide-variety of genes essential for development and ...

https://en.wikipedia.org/wiki/Short_interspersed_nuclear_element

Runx2 (which may also be known as Cbfa1), and Osx (a zinc finger containing transcription factor) are necessary for ...

https://en.wikipedia.org/wiki/Osteochondroprogenitor_cell

Zinc finger protein GLI2 also known as GLI family zinc finger 2 is a protein that in humans is encoded by the GLI2 gene. The ... Gli family zinc finger proteins are mediators of Sonic hedgehog (Shh) signaling and they are implicated as potent oncogenes in ... GLI2 belongs to the C2H2-type zinc finger protein subclass of the Gli family. Members of this subclass are characterized as ... "Entrez Gene: GLI family zinc finger 2". Tojo M, Kiyosawa H, Iwatsuki K, Nakamura K, Kaneko F (May 2003). "Expression of the ...

https://en.wikipedia.org/wiki/GLI2

Hu HM, Arcinas M, Boxer LM (March 2002). "A Myc-associated zinc finger protein-related factor binding site is required for the ...

https://en.wikipedia.org/wiki/MYC

The mouse PRC2 has four subunits: Suz12 (zinc finger), Eed, Ezh1 or Ezh2 (SET domain with histone methyltransferase activity) ...

https://en.wikipedia.org/wiki/PRC2

It interacts with HIV-1 Gag protein through Zinc Finger of HIV-1 Gag. GRCh38: Ensembl release 89: ENSG00000147604 - Ensembl, ... Witte S, Krawinkel U (August 1997). "Specific interactions of the autoantigen L7 with multi-zinc finger protein ZNF7 and ... "Specific interactions of the autoantigen L7 with multi-zinc finger protein ZNF7 and ribosomal protein S7". The Journal of ...

https://en.wikipedia.org/wiki/60S_ribosomal_protein_L7

"Entrez Gene: ZNF193 zinc finger protein 193". Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the ... Zinc finger protein 193 is a protein that in humans is encoded by the ZNF193 gene. GRCh38: Ensembl release 89: ENSG00000137185 ... 1997). "Three genes encoding zinc finger proteins on human chromosome 6p21.3: members of a new subclass of the Kruppel gene ... Williams AJ, Blacklow SC, Collins T (2000). "The Zinc Finger-Associated SCAN Box Is a Conserved Oligomerization Domain". Mol. ...

https://en.wikipedia.org/wiki/ZNF193

... using zinc-finger nuclease technology, are being commercialized by SAGE Labs. Laboratory mouse Animal testing on rodents Morris ...

https://en.wikipedia.org/wiki/Laboratory_rat

The protein, which contains a C2-C2 zinc finger-like domain that can bind to zinc, can enhance the tumor suppressor activity of ...

https://en.wikipedia.org/wiki/40S_ribosomal_protein_S29

Zinc finger protein Rlf is a protein that in humans is encoded by the RLF gene. GRCh38: Ensembl release 89: ENSG00000117000 - ... 1996). "The rearranged L-myc fusion gene (RLF) encodes a Zn-15 related zinc finger protein". Oncogene. 11 (12): 2699-704. PMID ...

https://en.wikipedia.org/wiki/RLF_(gene)

Zinc finger protein Gfi-1 is a transcriptional repressor that in humans is encoded by the GFI1 gene. It is important normal ... Zweidler-Mckay PA, Grimes HL, Flubacher MM, Tsichlis PN (1996). "Gfi-1 encodes a nuclear zinc finger protein that binds DNA and ... encoding a novel zinc finger protein reveals a new syntenic region between man and rodents". Cytogenet Cell Genet. 70 (3-4): ... "The zinc finger protein Gfi-1 can enhance STAT3 signaling by interacting with the STAT3 inhibitor PIAS3". EMBO J. 19 (21): 5845 ...

https://en.wikipedia.org/wiki/GFI1

This gene encodes a member of the RING zinc finger protein family found in striated muscle and iris. The product of this gene ... Dai KS, Liew CC (June 2001). "A novel human striated muscle RING zinc finger protein, SMRZ, interacts with SMT3b via its RING ... Kedar V, McDonough H, Arya R, Li HH, Rockman HA, Patterson C (December 2004). "Muscle-specific RING finger 1 is a bona fide ... MuRF1 is the name most commonly used in the literature, and it stands for "Muscle RING Finger 1." Structurally, there are two ...

https://en.wikipedia.org/wiki/TRIM63

... bric-a-brac/poxvirus and zinc finger (BTB/POZ) domains, which is atypical of CNC-bZip family members. These BTB/POZ domains ...

https://en.wikipedia.org/wiki/BACH1

C) DNA-binding domain (DBD): Highly conserved domain containing two zinc fingers that binds to specific sequences of DNA called ... a novel zinc finger motif (CHC2) is identified in parasitic flatworm NRs. (D) Hinge region: Thought to be a flexible domain ... "Nuclear receptors from the ctenophore Mnemiopsis leidyi lack a zinc-finger DNA-binding domain: lineage-specific loss or ...

https://en.wikipedia.org/wiki/Nuclear_receptor

It consists of binding sites for fork head domain factors and zinc finger transcription factors. TMEM125 has two variant ...

https://en.wikipedia.org/wiki/TMEM125

Tyrosine-protein kinase, or Bromodomain adjacent to zinc finger domain, 1B (BAZ1B) is an enzyme that in humans is encoded by ... "Entrez Gene: BAZ1B bromodomain adjacent to zinc finger domain, 1B". Zanella M, Vitriolo A, Andirko A, Martins PT, Sturm S, ... Pascual J, Martinez-Yamout M, Dyson HJ, Wright PE (December 2000). "Structure of the PHD zinc finger from human Williams-Beuren ...

https://en.wikipedia.org/wiki/BAZ1B

... and a ZZ-type zinc finger motif. This is likely involved in protein binding, and has recently been identified as a SUMOylation ... "DNA damage-inducible SUMOylation of HERC2 promotes RNF8 binding via a novel SUMO-binding Zinc finger". The Journal of Cell ... Lehman AL, Nakatsu Y, Ching A, Bronson RT, Oakey RJ, Keiper-Hrynko N, Finger JN, Durham-Pierre D, Horton DB, Newton JM, Lyon MF ... At the site of doubles stranded breaks, HERC2 facilitates the binding of RNF8, a RING finger ubiquitin ligase to the E2 ...

https://en.wikipedia.org/wiki/HERC2

... is a protein in humans that is encoded by the GZF1 gene. GRCh38: Ensembl release 89: ... "Entrez Gene: GDNF-inducible zinc finger protein 1". Retrieved 2013-05-28. v t e (Articles with short description, Short ...

https://en.wikipedia.org/wiki/Gdnf-inducible_zinc_finger_protein_1

... and the multivalent zinc finger factor, CTCF". J. Biol. Chem. 275 (38): 29915-21. doi:10.1074/jbc.M001538200. PMID 10906122. ... "RBBP6 interacts with multifunctional protein YB-1 through its RING finger domain, leading to ubiquitination and proteosomal ...

https://en.wikipedia.org/wiki/Y_box_binding_protein_1

The KOX zinc finger genes: genome wide mapping of 368 ZNF PAC clones with zinc finger gene clusters predominantly in 23 ... zinc finger protein 20provided by HGNC. Primary source. HGNC:HGNC:12992 See related. Ensembl:ENSG00000132010 MIM:194557; ... The zinc finger-associated SCAN box is a conserved oligomerization domain. Williams AJ, et al. Mol Cell Biol, 1999 Dec. PMID ... Multiple genes encoding zinc finger domains are expressed in human T cells. Thiesen HJ. New Biol, 1990 Apr. PMID 2288909 ...

https://www.ncbi.nlm.nih.gov/gene/7568

zinc finger nuclease. NHEJ. nonhomologous end-joining. HR. homologous recombination. KO. knockout. P-gp. P-glycoprotein. MDR/ ... The development of zinc finger nuclease (ZFN) technology has enabled the genetic engineering of the rat genome. The ability to ... Characterization of Multidrug Resistance 1a/P-Glycoprotein Knockout Rats Generated by Zinc Finger Nucleases. Xiaoyan Chu, Zuo ... Characterization of Multidrug Resistance 1a/P-Glycoprotein Knockout Rats Generated by Zinc Finger Nucleases ...

https://molpharm.aspetjournals.org/content/81/2/220

Compare Anti-zinc finger protein 874b Antibody Products from leading suppliers on Biocompare. View specifications, prices, ...

https://www.biocompare.com/pfu/110447/soids/1025268/Antibodies/zinc_finger_protein_874b

Solution structure of the third zinc finger domain of FOG-1 ... Zinc finger protein ZFPM1. A. 35. Mus musculus. Mutation(s): 3 ... Classic zinc finger domains (cZFs) consist of a beta-hairpin followed by an alpha-helix. They are among the most abundant of ... Classic zinc finger domains (cZFs) consist of a beta-hairpin followed by an alpha-helix. They are among the most abundant of ... A Classic Zinc Finger from Friend of GATA Mediates an Interaction with the Coiled-coil of Transforming Acidic Coiled-coil 3.. ...

https://www.rcsb.org/structure/1SRK

View mouse Gatad2a Chr8:70359726-70449034 with: phenotypes, sequences, polymorphisms, proteins, references, function, expression

http://www.informatics.jax.org/marker/MGI:2384585

The zinc finger transcription factor 191 is required for early embryonic development and cell proliferation. Li, J., Chen, X., ... Chromosomal localization of two human zinc finger protein genes, ZNF24 (KOX17) and ZNF29 (KOX26), to 18q12 and 17p13-p12, ... Molecular cloning of six novel Krüppel-like zinc finger genes from hematopoietic cells and identification of a novel ... Establishment of transgenic mice carrying gene encoding human zinc finger protein 191. Li, J.Z., Chen, X., Yang, H., Wang, S.L ...

https://www.wikigenes.org/e/gene/e/7572.html

Timeline for Protein Zinc finger FYVE domain-containing protein 19 from g.43.1.1: B-box zinc-binding domain: *Protein Zinc ... Protein Zinc finger FYVE domain-containing protein 19 from g.43.1.1: B-box zinc-binding domain appears in SCOPe 2.07. ... More info for Protein Zinc finger FYVE domain-containing protein 19 from g.43.1.1: B-box zinc-binding domain. ... Lineage for Protein: Zinc finger FYVE domain-containing protein 19. *Root: SCOPe 2.08 *. Class g: Small proteins [56992] (100 ...

http://scop.berkeley.edu/sunid=161200

The human zinc finger antiviral protein (ZAP) is capable of inhibiting several major human pathogens, including Influenza A ... The human zinc finger antiviral protein (ZAP) is capable of inhibiting several major human pathogens, including Influenza A ... Role and modulation of Zinc-finger antiviral protein and antiviral Regnase-1-like endonucleases. ...

https://cordis.europa.eu/project/id/101062524

First-in-human in vivo genome editing via AAV-zinc finger nucleases for mucopolysaccharidosis I/II and hemophilia B ... Non-viral Delivery of Zinc Finger Nuclease mRNA Enables Highly Efficient In Vivo Genome Editing of Multiple Therapeutic Gene ... Diversifying the structure of zinc finger nucleases for high-precision genome editing ...

https://www.sangamo.com/category/publications/zinc-finger-nuclease/

Engineered zinc finger protein transcription factors (ZFP TFs) can be designed to specifically increase the level of a ... Engineered zinc finger protein transcription factors (ZFP TFs) can be designed to specifically increase the level of a ... Develop Engineered Zinc Finger Protein Transcriptional Activators of the Glial Cell Line-Derived Neurotrophic Factor (GDNF) ... Development of a Zinc Finger Protein Therapeutic for the Potential Treatment of Parkinsons Disease ...

https://www.michaeljfox.org/grant/development-zinc-finger-protein-therapeutic-potential-treatment-parkinsons-disease

Some compounds were also screened for their inhibitory effect of the zinc-finger protein. PARP-1, essential for DNA repair and ... biological characterization and investigation of their inhibition properties of the zinc finger protein. PARP-1 M. Serratrice, ... biological characterization and investigation of their inhibition properties of the zinc finger protein PARP-1† ...

https://pubs.rsc.org/en/content/articlelanding/2012/DT/C2DT11913G

A team of researchers lead by Huanzhang Zhu used the on target DNA cleaving potential of zinc finger nucleases to cleave the ... To do this they targeted zinc finger-FokI fusions to a sequence within the extremely well conserved long terminal repeat (LTR) ... In fact, a team of researchers lead by Huanzhang Zhu used the on target DNA cleaving potential of zinc finger nucleases to ... The team concluded that the use of their designed zinc finger as part of a therapeutic strategy, could indeed eradicate the ...

https://epigenie.com/cutting-edge-hiv-therapy-with-zinc-finger-nucleases/

Zinc finger proteins: New insights into structural and functional diversity. Curr. Opin. Struct. Biol. 2001; 11:39-46. ... Zinc finger proteins as designer transcription factors. J. Biol. Chem. 2000; 275:8742-8. ... Adaptive evolution in zinc finger transcription factors. PLoS Genet. 2009; 5:e1000325. ... Analysis of an artificial zinc finger epigenetic modulator: widespread binding but limited regulation. Nucleic Acids Res. 2014 ...

https://www.oncotarget.com/article/11142/text/

We derived the modeling approach for generating a three-Cys2His2 zinc-finger-DNA complex model according to the results of ... Our docking data demonstrate that two AIRs with a reasonable geometric distribution in each of the three-Cys2His2 zinc-finger ... This approach is efficient for generating a zinc-finger protein-DNA complex model for unknown complex structures in which the ... Defining the ambiguous interaction restraints for the classical three-Cys2His2 zinc-finger proteins that wrap around DNA is ...

https://bmcbioinformatics.biomedcentral.com/articles/10.1186/1471-2105-11-334/figures/5

Dive into the research topics of The T-Box near the Zinc Fingers of the Human Vitamin D Receptor Is Required for Heterodimeric ... The T-Box near the Zinc Fingers of the Human Vitamin D Receptor Is Required for Heterodimeric DNA Binding and Transactivation. ...

https://asu.pure.elsevier.com/en/publications/the-t-box-near-the-zinc-fingers-of-the-human-vitamin-d-receptor-i/fingerprints/

Lu, Yan, "The Role of Thylakoid Zinc-Finger Proteins in Photosynthesis" (2014). Faculty Research and Creative Activities Award ...

https://scholarworks.wmich.edu/fracaa/32/

title = "Chromosomal localization of four human zinc finger cDNAs",. abstract = "cDNA clones encoding zinc finger motifs were ... cDNA clones encoding zinc finger motifs were isolated by screening human placenta and T-cell (Peer) cDNA libraries with zinc ... cDNA clones encoding zinc finger motifs were isolated by screening human placenta and T-cell (Peer) cDNA libraries with zinc ... cDNA clones encoding zinc finger motifs were isolated by screening human placenta and T-cell (Peer) cDNA libraries with zinc ...

https://moh-it.pure.elsevier.com/en/publications/chromosomal-localization-of-four-human-zinc-finger-cdnas

Identification of a novel TGF-β-regulated gene encoding a putative zinc finger protein in human osteoblasts. In: Nucleic acids ... Identification of a novel TGF-β-regulated gene encoding a putative zinc finger protein in human osteoblasts. Nucleic acids ... Dive into the research topics of Identification of a novel TGF-β-regulated gene encoding a putative zinc finger protein in ... The TIEG protein contains three zinc finger motifs, several proline-rich src homology-3 (SH3) binding domains at the C-terminal ...

https://mayoclinic.pure.elsevier.com/en/publications/identification-of-a-novel-tgf-%CE%B2-regulated-gene-encoding-a-putativ

In this complex, the zinc fingers bind in the major groove of B-DNA and wrap part way around the double helix. Each finger has ... This is the protein part of a two-part zinc finger mold, where the DNA model binds into the Zn Model. This is a nested model ... The zinc finger DNA-binding motif occurs in many proteins that regulate eukaryotic gene expression. The crystal structure of a ... This structure provides a framework for understanding how zinc fingers recognize DNA and suggests that this motif may provide a ...

https://3dprint.nih.gov/discover/3dpx-003620

RNA binding by the Wilms tumor suppressor zinc finger proteins. A A Caricasole, Antonio Duarte, S H Larsson, N D Hastie, M ... Dive into the research topics of RNA binding by the Wilms tumor suppressor zinc finger proteins. Together they form a unique ...

https://researchportal.bath.ac.uk/en/publications/rna-binding-by-the-wilms-tumor-suppressor-zinc-finger-proteins/fingerprints/?sortBy=alphabetically

Phenotype data for mouse gene Zfp566. Discover Zfp566s significant phenotypes, expression, images, histopathology and more. Data for gene Zfp566 is all freely available for download.

https://www.mousephenotype.org/data/genes/MGI:1919806

We show by cloning the id1 gene that it encodes a protein with zinc finger motifs, suggesting that the id1 gene product ... The indeterminate gene encodes a zinc finger protein and regulates a leaf-generated signal required for the transition to ... Colasanti, J., Yuan, Z., Sundaresan, V. (1998-05-15). The indeterminate gene encodes a zinc finger protein and regulates a leaf ...

https://scholarbank.nus.edu.sg/handle/10635/134130

Zinc Finger Design AI Tool Opens Door to Large-Scale Gene Therapies ... Zinc Finger Design AI Tool Opens Door to Large-Scale Gene Therapies. ...

https://www.genengnews.com/category/magazine/november-15-2018-vol-38-no-20/supplement-november-15-2018-vol-38-no-20/

"PHD Zinc Fingers" by people in this website by year, and whether "PHD Zinc Fingers" was a major or minor topic of these ... Zinc finger domains of approximately 50 to 80 amino acids in length that are characterized by a conserved Cysteine(3)-Histidine ... "PHD Zinc Fingers" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical Subject ... Below are the most recent publications written about "PHD Zinc Fingers" by people in Profiles. ...

https://profiles.jefferson.edu/display/19839686

The KRAB-zinc finger proteins (KRAB-ZFPs) represent a very large, but poorly understood, family of transcriptional regulators ... KRAB zinc-finger proteins localise to novel KAP1-containing foci that are adjacent to PML nuclear bodies. ... View more ,The KRAB-zinc finger proteins (KRAB-ZFPs) represent a very large, but poorly understood, family of transcriptional ...

https://research-repository.griffith.edu.au/handle/10072/40334

Comparison of KRC protein zinc finger domains. The zinc finger amino acid sequences of the KRC ZAS domains are compared. Mouse ... The zinc finger 1 and zinc finger 2 domains within the ZAS domains are designated in green and blue font, respectively, in the ... and at position 2 of the second zinc finger (outlined in gray). The linker region between the two zinc fingers is outlined in ... between the first and second zinc fingers of the ZAS-N and ZAS-C domains except at position 3 of the first zinc finger ( ...

https://bmcimmunol.biomedcentral.com/articles/10.1186/1471-2172-3-10/figures/16

Our results demonstrate that expression of the tumor suppressor promyelocytic leukemia zinc finger (PLZF) is decreased in GC ... Our results demonstrate that expression of the tumor suppressor promyelocytic leukemia zinc finger (PLZF) is decreased in GC ... Extracellular vesicle derived miR-544 downregulates expression of tumor suppressor promyelocytic leukemia zinc finger resulting ... Extracellular vesicle derived miR-544 downregulates expression of tumor suppressor promyelocytic leukemia zinc finger resulting ...

https://aging-us.com/article/104082

Of the 18 zinc fingers contained within ZFP100, the region encompassing fingers 2-6 is sufficient to maintain CB localization. ... Of the 18 zinc fingers contained within ZFP100, the region encompassing fingers 2-6 is sufficient to maintain CB localization. ... Of the 18 zinc fingers contained within ZFP100, the region encompassing fingers 2-6 is sufficient to maintain CB localization. ... Of the 18 zinc fingers contained within ZFP100, the region encompassing fingers 2-6 is sufficient to maintain CB localization. ...

https://researchexperts.utmb.edu/en/publications/conserved-zinc-fingers-mediate-multiple-functions-of-zfp100-a-u7s

Zinc-Finger Nucleases Induced by HIV-1 Tat Excise HIV-1 From the Host Genome in Infected and Latently Infected Cells. Mol Ther ... Zinc Finger Nuclease. In a preliminary study, ZFN-modified CD4+ T cells with disruption of CCR5 were engrafted into NOD/SCID/ ... Zinc-Finger Nuclease Editing of Human Cxcr4 Promotes HIV-1 Cd4(+) T Cell Resistance and Enrichment. Mol Ther (2012) 20(4):849- ... Simultaneous Zinc-Finger Nuclease Editing of the HIV Coreceptors Ccr5 and Cxcr4 Protects CD4+ T Cells From HIV-1 Infection. ...

https://www.frontiersin.org/articles/10.3389/fimmu.2021.688747/full

2021 , In Memory of Dr. Olusola Akinyele. By Alphegaservices ...

https://www.akinyele-legacy.com/profile/adwellburanx/forum-comments

The zinc finger DNA-binding motif occurs in many proteins that regulate eukaryotic gene expression. (nih.gov)
PHD fingers occur in many proteins that function in chromatin-mediated gene expression and EPIGENETICS such as POLYCOMB-GROUP PROTEINS. (jefferson.edu)
The KRAB-zinc finger proteins (KRAB-ZFPs) represent a very large, but poorly understood, family of transcriptional regulators in mammals. (edu.au)
Within these chimeric proteins, the DNA binding specificity of the zinc finger protein determines the site of nuclease action.Once the engineered ZFNs recognize and bind to their specified locus, it leads to the dimerization of the two nuclease domains on the ZFNs to evoke a double-strand break (DSB) in the targeted DNA. (wustl.edu)
Finger like and finger proteins are like zinc fingers small proteins with a structural motif that is characterized by the coordination of one or more zinc ions in order to stabilize the fold. (blimp-1.com)
Motifs in DNA - and RNA-binding proteins whose amino acids are folded into a single structural unit around a zinc atom. (bvsalud.org)
argylesock says… Zinc finger nucleases (ZFN) are proteins which can be used in genetic modification (GM, genetic engineering, GE). (wordpress.com)
The association is referring to zinc finger nucleases (ZFNs), a class of engineered DNA-binding proteins that facilitate targeted editing of the genome by creating double-strand breaks in DNA at user-specified locations. (wordpress.com)
YY1 is a ubiquitously distributed transcription factor belonging to the GLI-Kruppel class of zinc finger proteins. (abbkine.com)
Adjustments in the manifestation of transcription elements like Zinc finger E-box-binding homeobox 1/2 (ZEB1/2), Zinc finger proteins SNAIL1 (SNAIL), Twist-related proteins 1 (TWIST) or vimentin (VIM) might become prognostic factors along the way of carcinogenesis [16]. (cancerhugs.com)

In fact, a team of researchers lead by Huanzhang Zhu used the on target DNA cleaving potential of zinc finger nucleases to cleave the HIV-1 provirus out of infected human T-cells. (epigenie.com)
A significant advancement toward this objective was achieved with the advent of a novel technology that enables high-frequency and high-fidelity genome editing via the application of custom designed zinc finger nucleases (ZFNs). (wustl.edu)
Human hematopoietic stem/progenitor cells modified by zinc-finger nucleases targeted to CCR5 control HIV-1 in vivo. (nature.com)
In one case zinc finger nucleases were used to delete the CCR5 gene inÂ a patient's cells, a procedure that we discussed in TWiV #278 . (virology.ws)
Modification of existing genes in living animal and human cells is enabled by engineered nucleases such as meganucleases, zinc finger nucleases, transcription activator-like effector-based nucleases, and the CRISPR-Cas system. (cdc.gov)
Early methods for targeting DSB-inducing nucleases to specific genomic sites relied on protein-based systems with customizable DNA-binding specificities such as meganucleases, zinc finger nucleases (ZFNs) and transcription activator-like effector nucleases (TALENs). (cdc.gov)
We established a broadly applicable strategy using zinc finger nucleases (ZFNs) and transcription activator-like effector nucleases (TALENs) for targeted disruption of endogenous genes and cis-acting regulatory elements in diverged nematode species. (bioseek.eu)

The development of zinc finger nuclease (ZFN) technology has enabled the genetic engineering of the rat genome. (aspetjournals.org)
However, they also stress that delivery of these gene-editing tools in clinical settings remains a pickle, but propose a strategy of transplanted autologous CD34+ cells pretreated with zinc-finger nuclease as the way to go. (epigenie.com)
Generation of Esr1-knockout rats using zinc finger nuclease-mediated genome editing. (childrensmercy.org)
This entry was posted in agriculture , horticulture , knowledge transfer and tagged biotechnology , crop , crop variety , genetic modification , law , zinc finger nuclease . (wordpress.com)

cDNA clones encoding zinc finger motifs were isolated by screening human placenta and T-cell (Peer) cDNA libraries with zinc finger (ZNF) consensus sequences. (elsevier.com)
The TIEG protein contains three zinc finger motifs, several proline-rich src homology-3 (SH3) binding domains at the C-terminal end, and is homologous in this region to the zinc finger-containing transcription factor family of genes. (elsevier.com)
We show by cloning the id1 gene that it encodes a protein with zinc finger motifs, suggesting that the id1 gene product functions as a transcriptional regulator of the floral transition. (nus.edu.sg)
Zinc finger (Znf) domains are relatively small protein motifs which contain multiple finger-like protrusions that make tandem contacts with their target molecule. (embl.de)
Zinc-binding motifs are stable structures, and they rarely undergo conformational changes upon binding their target. (embl.de)

Zinc finger domains of approximately 50 to 80 amino acids in length that are characterized by a conserved Cysteine(3)-Histidine-Cysteine(4) amino acid motif which coordinates binding of two zinc ions. (jefferson.edu)
A ZFN is a chimeric protein that consists of the non-specific endonuclease domain of FokI fused to a DNA-binding domain composed of an engineered zinc-finger motif. (wustl.edu)
In the proposed "zinc finger" DNA-binding motif, each repeat unit binds a zinc metal ion through invariant Cys and His residues and this drives the folding of each 30-residue unit into an independent nucleic acid-binding domain. (embl.de)
By variations in the composition of the sequences in the fingertip and the number and spacing of tandem repeats of the motif, zinc fingers can form a large number of different sequence specific binding sites. (bvsalud.org)
U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit- related protein 2 (U2(RNU2) small nuclear RNA auxiliary factor 1-like 2) (CCCH type zinc finger, RNA-binding motif and serine/arginine rich protein 2) (Renal carcinoma antigen NY-REN-20). (yellowcouch.org)

The KOX zinc finger genes: genome wide mapping of 368 ZNF PAC clones with zinc finger gene clusters predominantly in 23 chromosomal loci are confirmed by human sequences annotated in EnsEMBL. (nih.gov)
Chromosomal localization of 9 KOX zinc finger genes: physical linkages suggest clustering of KOX genes on chromosomes 12, 16, and 19. (nih.gov)
Multiple genes encoding zinc finger domains are expressed in human T cells. (nih.gov)
Molecular cloning of six novel Krüppel-like zinc finger genes from hematopoietic cells and identification of a novel transregulatory domain KRNB. (wikigenes.org)
hunchback and Ikaros-like zinc finger genes control reproductive system development in Caenorhabditis elegans. (ncsu.edu)
The new zinc finger peptides of the invention may be particularly useful in the modulation of target genes associated with expanded GGGGCC hexanucleotide repeats or CGG trinucleotide repeats, and more specifically the targeted repression of such genes. (imperial.tech)
Likewise, hypoxic breast cancer cells showed higher propensity to increase expression of oncogenes and to decrease expression of tumor suppressor genes ( Jefford and Irminger-Finger, 2006 ). (frontiersin.org)

A transcriptional activator and oncogene protein that contains two CYS2-HIS2 ZINC FINGERS . (nih.gov)
A DNA-binding protein that contains an N-terminal BTB (POZ) DOMAIN and C-terminal CYS2-HIS2 ZINC FINGERS . (nih.gov)

Furthermore, 8 of 9 mothers of children with CHB had antibody reactivity against amino acids 1-135 of the Ro 52-kd protein, containing 2 putative zinc fingers reconstituted under reducing conditions. (nih.gov)

Interoperable with Gal4, the new system's key component is a fusion protein in which the DNA-binding domain of Gal4 has been replaced with a zinc finger domain with a different DNA-binding specificity. (a-star.edu.sg)

The human zinc finger antiviral protein (ZAP) is capable of inhibiting several major human pathogens, including Influenza A virus and SARS-CoV-2. (europa.eu)
SARS-CoV-2 Is Restricted by Zinc Finger Antiviral Protein despite Preadaptation to the Low-CpG Environment in Humans. (cdc.gov)

The zinc finger amino acid sequences of the KRC ZAS domains are compared. (biomedcentral.com)
The critical amino acid residues within the α helical regions of the zinc finger regions are identical at all corresponding positions between the first and second zinc fingers of the ZAS-N and ZAS-C domains except at position 3 of the first zinc finger (outlined in gray) and at position 2 of the second zinc finger (outlined in gray). (biomedcentral.com)
Zn fingers 5-10 are required for maximal binding of ZFP100 to a 20-amino-acid region of Lsm11, a U7 snRNP core protein. (utmb.edu)
Their binding properties depend on the amino acid sequence of the finger domains and of the linker between fingers, as well as on the higher-order structures and the number of fingers. (embl.de)

C2H2-type (classical) zinc fingers (Znf) were the first class to be characterised. (embl.de)
They contain a short beta hairpin and an alpha helix (beta/beta/alpha structure), where a single zinc atom is held in place by Cys(2)His(2) (C2H2) residues in a tetrahedral array. (embl.de)
This entry represents the classical C2H2 zinc finger domain. (embl.de)

AoSAP8-P encoding A20 and/or AN1 type zinc finger protein in asparagus officinalis L. Improving stress tolerance in transgenic Nicotiana sylvestris. (bvsalud.org)
The full length CDS of an A20 and AN1 type zinc finger gene (named AoSAP8-P), located nearby the male specific Y chromosome (MSY) region of Asparagus officinalis ( garden asparagus) was amplified by RT-PCR from purple passion. (bvsalud.org)

Classic zinc finger domains (cZFs) consist of a beta-hairpin followed by an alpha-helix. (rcsb.org)
They are similar structurally to RING FINGER DOMAINS, with a globular fold topology of two BETA-SHEETS and an ALPHA-HELIX. (jefferson.edu)
Comparison of KRC protein zinc finger domains. (biomedcentral.com)
The zinc finger 1 and zinc finger 2 domains within the ZAS domains are designated in green and blue font, respectively, in the consensus sequence. (biomedcentral.com)
Comparisons with other mammalian ZFP100 orthologs show that the central Zn fingers sufficient for in vivo activity are most highly conserved, whereas the number and sequence of the Zn fingers in the N- and C-terminal domains vary. (utmb.edu)
We generated two synthetic zinc-finger DNA-binding domains (ZF-DBDs) targeting this sequence. (elsevier.com)
Znf domains are often found in clusters, where fingers can have different binding specificities. (embl.de)
To obtain structural information, we synthesized single and double zinc finger peptides from the yeast transcription activator ADR1, and assessed the metal-binding and DNA-binding properties of these peptides, as well as the solution structure of the metal-stabilized domains, with the use of a variety of spectroscopic techniques. (embl.de)
Mutations conferring drug resistance were not confined to the N-terminal p53/Nutlin-binding domain, and were additionally seen in the acidic, zinc finger and RING domains. (ntu.edu.sg)

1985. Effects of marginal zinc deficiency on subclinical lead toxicity in the rat neonate. (cdc.gov)

Modulation of tissue trace metal concentrations in weanling rats fed different levels of zinc and exposed to oral lead and cadmium. (cdc.gov)

The present invention provides new zinc finger peptides and encoding nucleic acid molecules that can be used for the modulation of gene expression in vitro and/or in vivo. (imperial.tech)

Our prototype links the tandem zinc finger (TZF) domain from tristetraprolin (TTP) to the endoribonuclease RNase4 (R4). (cancer.gov)
We, recently, reported the Arabidopsis thaliana Tandem Zinc Finger protein 9 (TZF9) to be an RNA-binding protein co-localizing with components of RNA granules. (uni-halle.de)

We have studied the transcriptional co-regulator Friend of GATA (FOG), which contains nine zinc fingers. (rcsb.org)

Sangamo BioSciences, a Richmond, California-based pharmaceutical company, has developed a 'zinc fingers' technology that can home in on the CCR5 section of cellular DNA and artificially create a functional equivalent of the delta-32 mutation. (scientificamerican.com)

Of the 18 zinc fingers contained within ZFP100, the region encompassing fingers 2-6 is sufficient to maintain CB localization. (utmb.edu)

Encodes a zinc finger protein involved in high light and cold acclimation. (or.jp)

Kong W , Liu X , Yin G , Zheng S , Zhu A , Yu P , Shan Y , Ying R , Zhang J , . Extracellular vesicle derived miR-544 downregulates expression of tumor suppressor promyelocytic leukemia zinc finger resulting in increased peritoneal metastasis in gastric cancer. (aging-us.com)
Our results demonstrate that expression of the tumor suppressor promyelocytic leukemia zinc finger (PLZF) is decreased in GC tissues and PM lesions from GC patients. (aging-us.com)

The binding sites of Zinc atom in the Solution Structure of Miz-1 Zinc Finger 7 (pdb code 2m0f ). (atomistry.com)
This binding sites where shown within 5.0 Angstroms radius around Zinc atom. (atomistry.com)
In the classic zinc finger, one zinc atom is bound to two cysteines and two histidines. (bvsalud.org)

The Implications of Zinc Therapy in Combating the COVID-19 Global Pandemic. (cdc.gov)

Urthn Zinc Alloy Silver Plated 5 Fing. (jewelemarket.com)

A competitive ELISA for quantitative measurement of Human PR domain zinc finger protein 1 (PRDM1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. (blimp-1.com)

To understand the molecular consequences of dysregulated RNA regulons in cancer, the goal of this exploratory, high-risk/high-reward R21 proposal is to develop a zinc finger-directed RNA-cleaving agent to suppress RNA regulons that are upregulated in many tumors. (cancer.gov)

Antagonistic effects of zinc and aluminum on lead inhibition of *-aminolevulinic acid dehydratase. (cdc.gov)
1994. Inhibition of Na+-glucose cotransport in kidney cortical cells by cadmium and copper: Protection by zinc. (cdc.gov)
1976. The in vitro effect of zinc on the inhibition of human *-aminolevulinic acid dehydratase by lead. (cdc.gov)

PHD Zinc Fingers" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (jefferson.edu)

Zinc oxide in Portland cement. (elsevier.com)
In general, workers were concerned about their workplace exposures, specifically to acids and zinc oxide dust. (cdc.gov)

Engineered zinc finger protein transcription factors (ZFP TFs) can be designed to specifically increase the level of a therapeutically important protein from its native gene in a patients' own cells. (michaeljfox.org)

The protein contains a zinc finger and a polyalanine tract similar to ones previously implicated in DNA binding and transactivation or repression, respectively. (elsevier.com)

This is the protein part of a two-part zinc finger mold, where the DNA model binds into the Zn Model. (nih.gov)

To do this they targeted zinc finger- Fok I fusions to a sequence within the extremely well conserved long terminal repeat (LTR) U3 region of the HIV-1 provirus. (epigenie.com)

Establishment of transgenic mice carrying gene encoding human zinc finger protein 191. (wikigenes.org)

1988. Antagonistic effect of zinc in lead treated developing chick embryos. (cdc.gov)

Anatomy8

Organisms2

Diseases2

Chemicals and Drugs43

Analytical, Diagnostic and Therapeutic Techniques and Equipment12

Phenomena and Processes33

Information Science3

A Drosophila doublesex-related gene, terra, is involved in somitogenesis in vertebrates. (1/4650)

ETO-2, a new member of the ETO-family of nuclear proteins. (2/4650)

Nrg1 is a transcriptional repressor for glucose repression of STA1 gene expression in Saccharomyces cerevisiae. (3/4650)

The mouse Aire gene: comparative genomic sequencing, gene organization, and expression. (4/4650)

Identification and characterization of a zinc finger gene (ZNF213) from 16p13.3. (5/4650)

Leukemia translocation protein PLZF inhibits cell growth and expression of cyclin A. (6/4650)

RFLAT-1: a new zinc finger transcription factor that activates RANTES gene expression in T lymphocytes. (7/4650)

Mapping the functional domains of BRCA1. Interaction of the ring finger domains of BRCA1 and BARD1. (8/4650)

Zinc Fingers

Fingers

Molecular Sequence Data

DNA-Binding Proteins

Transcription Factors

Amino Acid Sequence

Zinc Compounds

Zinc Sulfate

Kruppel-Like Transcription Factors

Base Sequence

Zinc Oxide

Repressor Proteins

Binding Sites

Sequence Homology, Amino Acid

Zinc Isotopes

Protein Binding

Transcription Factor TFIIIA

DNA

Protein Structure, Tertiary

Zinc Acetate

Cloning, Molecular

RING Finger Domains

Metalloproteins

Promoter Regions, Genetic

Sequence Alignment

Nuclear Proteins

Zinc

Mutation

Recombinant Fusion Proteins

Finger Phalanges

Consensus Sequence

Cell Line

DNA, Complementary

Transcription, Genetic

Trigger Finger Disorder

Early Growth Response Protein 1

Gene Expression Regulation

Carrier Proteins

RNA, Messenger

Two-Hybrid System Techniques

Conserved Sequence

Tristetraprolin

Protein Engineering

RNA, Ribosomal, 5S

Gene Expression Regulation, Developmental

Transcriptional Activation

Metallothionein

Trans-Activators

Transfection

Ikaros Transcription Factor

WT1 Proteins

Models, Molecular

Mutagenesis, Site-Directed

Drosophila Proteins

Cell Nucleus

Amino Acid Motifs

DNA Primers

Recombinant Proteins

Erythroid-Specific DNA-Binding Factors

Cysteine

COS Cells

Homeodomain Proteins

Hand

GATA4 Transcription Factor

Plasmids

Fungal Proteins

Gene Library

Genes, Reporter

HeLa Cells

RNA-Binding Proteins

Xenopus Proteins

gag Gene Products, Human Immunodeficiency Virus

Movement

Protein Conformation

Drosophila

GATA1 Transcription Factor

Genes, Wilms Tumor

Sp1 Transcription Factor

Immediate-Early Proteins

Saccharomyces cerevisiae Proteins

$Gentaur Molecular :Prosci \ Located on chromosome 19, ZNF551 encodes a protein that is part of the zinc finger protein family. ...$ Gentaur Molecular :Prosci \ Located on chromosome 19, ZNF551 encodes a protein that is part of the zinc finger protein family. ...

$Gentaur Molecular :EIAab \ Mouse,Mus musculus,Sizn1,Smad-interacting zinc finger protein 1,Zcchc12,Zinc finger CCHC domain...$ Gentaur Molecular :EIAab \ Mouse,Mus musculus,Sizn1,Smad-interacting zinc finger protein 1,Zcchc12,Zinc finger CCHC domain...