Zeatin
Isopentenyladenosine
Plant Growth Regulators
Cytokinin activation of Arabidopsis cell division through a D-type cyclin. (1/67)
Cytokinins are plant hormones that regulate plant cell division. The D-type cyclin CycD3 was found to be elevated in a mutant of Arabidopsis with a high level of cytokinin and to be rapidly induced by cytokinin application in both cell cultures and whole plants. Constitutive expression of CycD3 in transgenic plants allowed induction and maintenance of cell division in the absence of exogenous cytokinin. Results suggest that cytokinin activates Arabidopsis cell division through induction of CycD3 at the G1-S cell cycle phase transition. (+info)A gene encoding the cytokinin enzyme zeatin O-xylosyltransferase of Phaseolus vulgaris. (2/67)
Zeatin is the most active and ubiquitous form of the naturally occurring cytokinins. Glycosyl conjugates of zeatin are found in many plant tissues and are considered important for storage and protection against degradative enzymes. Two enzymes catalyzing the formation of O-glycosyl derivatives of zeatin have been characterized, O-glucosyltransferase and O-xylosyltransferase, occurring in seeds of lima bean (Phaseolus lunatus) and bean (Phaseolus vulgaris), respectively. Recently, the ZOG1 gene (zeatin O-glucosyltansferase) was isolated from P. lunatis (). Based on the ZOG1 sequence, the ZOX1 gene (zeatin O-xylosyltransferase) was cloned from P. vulgaris. ZOX1 contains an open reading frame of 1362 bp that codes for a 454-amino acid peptide of 51 kD. The recombinant protein has properties identical to the native enzyme: it catalyzes O-xylosylzeatin formation with UDP-Xyl as a glycosyl donor but does not recognize UDP-Glucose as a substrate. The ZOX1 and ZOG1 genes exhibit 93% identity at the nucleotide level and 90% similarity at the amino acid level. Neither gene contains introns. These zeatin-specific genes and their promoters will be useful for studies of the regulation of active versus storage forms of cytokinins. Comparison of sequences encoding similar enzymes with distinct substrate specificity may lead to identification of epitopes specific to cytokinin and glycosyl donor molecules. (+info)A low content in zeatin type cytokinins is not restrictive for the occurrence of G1/S transition in tobacco BY-2 cells. (3/67)
Theories on the importance of cytokinins in G1/S transition control are manifold and contradictory. By establishing a double A(phi-PZ block, maximal synchronization of a BY-2 suspension culture was obtained to investigate the effect of cytokinin depletion on G1/S transition. Lovastatin was used as a specific inhibitor of cytokinin biosynthesis. Flow cytometry showed that the G1/S transition occurred regardless of the cytokinin drop. This observation indicates an extremely low dose requiry for that stage of the cell cycle. It is very likely that precisely the downregulation of zeatin type cytokinins matters for the G1/S transition to occur, since cytokinin addition at early G1 blocked the cycle at G1/S. (+info)Cell-division factors from Vinca rosca L. crown gall tumor tissue. (4/67)
A cell-division factor has been precipitated from extracts of cultured Vinca rosea L. crown gall tumor tissue by using the mercuric acetate procedure previously employed by Wood and colleagues to obtain their "cytokinesin I." On the basis of its mass spectrum, ultraviolet light absorbancy spectra, solubilities, chromatographic migration values, and growth activity, the factor is ribosyl-trans-zeatin, that is, 6-(4-hydroxy-3-methyl-trans-2-butenylamino)-9-beta-D-ribofuranosylpurine. Ribosylzeatin has now been isolated from tumor tissue by four experimental techniques; any possibility that it is an artifact seems to have been eliminated. Contrary to the report by Wood and colleagues, synthetic ribosylzeatin is precipitated from an aqueous solution by mercuric acetate, provided the complete precipitation procedure is utilized. These facts and others discussed strongly support our suggestion that ribosylzeatin was present in the preparation ("cytokinesin I") examined by Wood and colleagues in several biological assays. The reasons advanced by Wood and others for rejecting this suggestion have been found either not to be pertinent to the question or to have insufficient experimental bases. (+info)Stunted plant 1 mediates effects of cytokinin, but not of auxin, on cell division and expansion in the root of Arabidopsis. (5/67)
Plants control organ growth rate by adjusting the rate and duration of cell division and expansion. Surprisingly, there have been few studies where both parameters have been measured in the same material, and thus we have little understanding of how division and expansion are regulated interdependently. We have investigated this regulation in the root meristem of the stunted plant 1 (stp1) mutation of Arabidopsis, the roots of which elongate more slowly than those of the wild type and fail to accelerate. We used a kinematic method to quantify the spatial distribution of the rate and extent of cell division and expansion, and we compared stp1 with wild type and with wild type treated with exogenous cytokinin (1 microM zeatin) or auxin (30 nM 2,4-dichlorophenoxyacetic acid). All treatments reduced average cell division rates, which reduced cell production by the meristem. Auxin lowered root elongation by narrowing the elongation zone and reducing the time spent by a cell in this zone, but did not decrease maximal strain rate. In addition, auxin increased the length of the meristem. In contrast, cytokinin reduced root elongation by lowering maximal strain rate, but did not change the time spent by a cell within the elongation zone; also, cytokinin blocked the increase in length and cell number of the meristem and elongation zone. The cytokinin-treated wild type phenocopied stp1 in nearly every detail, supporting the hypothesis that cytokinin affects root growth via STP1. The opposite effects of auxin and cytokinin suggest that the balance of these hormones may control the size of the meristem. (+info)A maize cytokinin gene encoding an O-glucosyltransferase specific to cis-zeatin. (6/67)
Zeatin is a naturally occurring cytokinin. Biosynthesis and metabolism studies of zeatin have been directed mostly at the trans isomer, although cis-zeatin and its riboside occur as major components in some plant species. It is not known whether parallel regulatory pathways exist for the two isomers. Based on the sequence of the gene ZOG1 encoding a trans-zeatin O-glucosyltransferase from Phaseolus (EC ), a cis-zeatin-specific O-glucosyltransferase was isolated from maize. This gene, cisZOG1, contains an ORF of 1,401 nucleotides encoding a protein of 51.1 kDa with 41% identity to the Phaseolus ZOG1 protein. Unexpectedly, the maize enzyme recognizes as substrates cis-zeatin and UDP-glucose but not cis-ribosylzeatin, trans-zeatin, or trans-ribosylzeatin. This finding indicates the existence of cis-specific regulatory elements in plants and suggests that cis-zeatin and derivatives may be more important in cytokinin homeostasis than currently recognized. (+info)Enzymic synthesis of indole-3-acetyl-1-O-beta-d-glucose. II. Metabolic characteristics of the enzyme. (7/67)
The synthesis of indole-3-acetyl-1-O-beta-D-glucose from indole-3-acetic acid (IAA) and uridine diphosphoglucose (UDPG) has been shown to be a reversible reaction with the equilibrium away from ester formation and toward formation of IAA. The enzyme occurs primarily in the liquid endosperm of the corn kernel but some activity occurs in the embryo. It is relatively specific showing no glucose ester formation with oxindole-3-acetic acid or 7-hydroxy-oxindole-3-acetic acid, and low activity with phenylpropene acids, such as rho-coumaric acid. The enzyme is also specific for the nucleotide sugar showing no activity with UDPGalactose or UDPXylose. The enzyme is inhibited by inorganic pyrophosphate, by phosphate esters and by phospholipids, particularly phosphatidyl ethanolamine. The enzyme is inhibited by zeatin, by 2,4-dichlorophenoxy-acetic acid, by IAA-myo-inositol and IAA-glucan, but not by zeatin riboside, and only weakly by gibberellic acid, abscisic acid and kinetin. The reaction is slightly stimulated by both calcium and calmodulin and, in some cases, by thiol compounds. The role of this enzyme in the homeostatic control of indole-3-acetic acid levels in Zea mays is discussed. (+info)Hormonal changes in the grains of rice subjected to water stress during grain filling. (8/67)
Lodging-resistant rice (Oryza sativa) cultivars usually show slow grain filling when nitrogen is applied in large amounts. This study investigated the possibility that a hormonal change may mediate the effect of water deficit that enhances whole plant senescence and speeds up grain filling. Two rice cultivars showing high lodging resistance and slow grain filling were field grown and applied with either normal or high amount nitrogen (HN) at heading. Well-watered and water-stressed (WS) treatments were imposed 9 days post anthesis to maturity. Results showed that WS increased partitioning of fixed (14)CO(2) into grains, accelerated the grain filling rate but shortened the grain filling period, whereas the HN did the opposite way. Cytokinin (zeatin + zeatin riboside) and indole-3-acetic acid contents in the grains transiently increased at early filling stage and WS treatments hastened their declines at the late grain filling stage. Gibberellins (GAs; GA(1) + GA(4)) in the grains were also high at early grain filling but HN enhanced, whereas WS substantially reduced, its accumulation. Opposite to GAs, abscisic acid (ABA) in the grains was low at early grain filling but WS remarkably enhanced its accumulation. The peak values of ABA were significantly correlated with the maximum grain filling rates (r = 0.92**, P < 0.01) and the partitioning of fixed (14)C into grains (r = 0.95**, P < 0.01). Exogenously applied ABA on pot-grown HN rice showed similar results as those by WS. Results suggest that an altered hormonal balance in rice grains by water stress during grain filling, especially a decrease in GAs and an increase in ABA, enhances the remobilization of prestored carbon to the grains and accelerates the grain filling rate. (+info)Zeatin is not a medical term per se, but it is a significant compound in the field of plant biology and agriculture. It is a type of cytokinin, which is a class of hormones that play crucial roles in plant growth and development. Specifically, zeatin is involved in cell division, differentiation, and delaying senescence (aging) in plants.
In a broader biological context, understanding the functions of phytohormones like zeatin can have implications for agricultural practices and crop management, which may indirectly impact human health through improved food production and quality.
Isopentenyladenosine (IPA) is a derivative of adenosine, which is a nucleoside consisting of adenine attached to ribose sugar via a β-N9-glycosidic bond. In Isopentenyladenosine, an isopentenyl group (a hydrocarbon chain with five carbon atoms) is added to the N6 position of the adenine base.
Isopentenyladenosine is a key intermediate in the biosynthesis of cytokinins, a class of plant hormones that play crucial roles in cell division and differentiation, shoot initiation, leaf expansion, apical dominance, root growth, and other developmental processes.
It's worth noting that Isopentenyladenosine is not typically used as a medical term or definition but rather in the context of biochemistry and plant physiology.
Plant growth regulators (PGRs) are natural or synthetic chemical substances that, when present in low concentrations, can influence various physiological and biochemical processes in plants. These processes include cell division, elongation, and differentiation; flowering and fruiting; leaf senescence; and stress responses. PGRs can be classified into several categories based on their mode of action and chemical structure, including auxins, gibberellins, cytokinins, abscisic acid, ethylene, and others. They are widely used in agriculture to improve crop yield and quality, regulate plant growth and development, and enhance stress tolerance.
"Phaseolus" is a term that refers to a genus of plants in the legume family Fabaceae, also known as the pea family. The most common and well-known species in this genus is "Phaseolus vulgaris," which is commonly called the common bean. This includes many familiar varieties such as kidney beans, black beans, navy beans, pinto beans, and green beans.
These plants are native to the Americas and have been cultivated for thousands of years for their edible seeds (beans) and pods (green beans). They are an important source of protein, fiber, vitamins, and minerals in many diets around the world.
It's worth noting that "Phaseolus" is a taxonomic term used in the scientific classification of plants, and it does not have a specific medical definition. However, the beans from these plants do have various health benefits and potential medicinal properties, such as being associated with reduced risk of heart disease, improved gut health, and better blood sugar control.
Zeatin
Zeatin reductase
Zeatin 9-aminocarboxyethyltransferase
Zeatin O-beta-D-xylosyltransferase
Trans-zeatin O-beta-D-glucosyltransferase
Cis-zeatin O-beta-D-glucosyltransferase
Vanilla
Pink-Pigmented Facultative Methylotrophs
Cytokinin 7-beta-glucosyltransferase
Botany
Jessica A. Scoffield
Hyperhydricity
Coconut milk
Cytokinin
Suresh Rattan
Plant hormone
List of MeSH codes (D03)
Rhodococcus fascians
Adenosine A2A receptor
List of EC numbers (EC 2)
List of EC numbers (EC 4)
List of EC numbers (EC 1)
Xylosyltransferase
Zeatin - Wikipedia
Zeatin reductase - Wikipedia
RCSB PDB - 3T4L: Arabidopsis histidine kinase 4 sensor domain in complex with trans-zeatin
KEGG PATHWAY: Zeatin biosynthesis - Oryza sativa japonica (Japanese rice) (RefSeq)
zeatin - Barton Publishing Blog
Trans-Zeatin 99% Plant Hormones
zeatin Archives - Nutritional Aesthetics™ Alliance
Zeatin Archives - Reveal Beauty Plastic Surgery
The effects of zeatin,zeatin riboside and their combinations on periderm formation in Coleus scutellarioides Bent. | AVESİS
Zeatin supplement improves scopolamine-induced memory impairment in mice<...
White Crystal Powder Plant Growth Regulators Cytokinin Plant Hormone Zeatin 98% TC
Impact of Seaweed Extract-Based Cytokinins and Zeatin Riboside on Creeping Bentgrass Heat Tolerance
2H5]trans-ZEATIN (D-tZ)[6-[2H5]((E)-4-hydroxy-3-methylbut-2-enylamino)purine] -Bio-thing
PDF) Pathogenetic trial of boric acid in bean and tomato plants
50MG Archives - Caisson Labs
Publication : USDA ARS
Publication : USDA ARS
Advanced Search Results - Public Health Image Library(PHIL)
Rodeo Canada - Official Home of the Canadian Professional Rodeo Association
SMART: ZnF C2H2 domain annotation
SMART: ZnF C2H2 domain annotation
Výpis publikací
Regeneration Efficiency Of Five High Yielding Potato Varieties Of Bangladesh | Bangladesh Journal of Botany
2023年4月17日-4月23日 | 理化学研究所
SCIENTIFIC REPORTS | Ústav experimentální botaniky AV ČR, v. v. i.
Frontiers | Decoding Gene Networks Modules That Explain the Recovery of Hymenoglossum cruentum Cav. After Extreme Desiccation
Blogdorf Goodman: Random Acts of Kinerase: Part 2
Optimizing the micropropagation protocol for the endangered Aloe polyphylla: can meta-topolin and its derivatives serve as...
Riboside6
- The effects of zeatin,zeatin riboside and their combinations on periderm formation in Coleus scutellarioides Bent. (yyu.edu.tr)
- The effects of zeatin,zeatin riboside an. (yyu.edu.tr)
- This study was designed to determine whether SWE-based cytokinins affect creeping bentgrass heat tolerance, and to compare effects of SWE-based cytokinins to those of a trans -zeatin riboside ( t -ZR)-standard. (bioagservicescorp.com)
- t -ZR, trans- zeatin riboside. (bioagservicescorp.com)
- 2002) noted that root- zone-injection of zeatin riboside increased endogenous cytokinins, antioxidant activity, and delayed senescence in heat-stressed creeping bentgrass. (bioagservicescorp.com)
- Wound-induced activation of cytokinin biosynthesis was suggested by the appearance of precursors (trans) zeatin riboside and (cis) zeatin riboside (t-ZR and c-ZR respectively) at 0.5 d and large increases in IPA and c-ZR by 3 d and throughout 7 d after wounding. (usda.gov)
Biosynthesis3
- they could make more (biosynthesis), they could transport zeatin into or away from the tissue, or they could break down or modify zeatin so it is no longer active. (usda.gov)
- By comparison, the most significant low-temperature responsive genes of LS6 were determined to be enriched in plant-pathogen interactions, zeatin biosynthesis, and plant hormone signal transduction. (eapr.net)
- In addition, compared to the common transcriptional response to Pb stress in both cultivars, the regulation of numerous genes including those involved in zeatin biosynthesis, limonene and pinene degradation, phagosome was exclusive to one cultivar. (biomedcentral.com)
Cytokinin5
- Zeatin is a cytokinin derived from adenine, which occurs in the form of a cis- and a trans-isomer and conjugates. (wikipedia.org)
- Zeatin is a member of the cytokinin family, a class of phytohormones involved in various processes of growth and development in plants. (kegg.jp)
- These results suggest that increased O-glycosylation of zeatin leads to complex changes in plant development and cytokinin composition. (usda.gov)
- Abscisic acid (ABA), indole acetic acid (IAA), gibberellic acid (GA), salicylic acid (SA), cytokinin, zeatin, and jasmonic acid contents and gene expressions related to them were investigated. (tubitak.gov.tr)
- As a result of the study, we determined that there was a significant decrease in the content of IAA, GA, SA, cytokinin, zeatin, and jasmonic acid with increasing doses of drought and Cd. (tubitak.gov.tr)
Kinetin6
- Most abundant cytokinins are adenine-type, where the N6 position of adenine is substituted with an isoprenoid, such as in zeatin, or an aromatic side chain, such as in kinetin. (kegg.jp)
- Day 16: Kinerase Pro + Therapy Lotion with Kinetin & Zeatin and. (blogspot.com)
- I am using 2 Kinerase Pro + Therapy moisturizers after cleansing with the Kinerase gentle daily cleanser: Lotion with kinetin & zeatin and Ultra rich night repair. (blogspot.com)
- Kinerase pro + therapy Lotion with kinetin & zeatin is non-comedogenic, hypoallergenic and for all skin types. (blogspot.com)
- This lotion contains kinetin & zeatin to help improve fine lines and wrinkles. (blogspot.com)
- It also contains the kinetin and zeatin along with plant based extracts for treating the visible signs of skin aging minimizing wrinkles, fine lines, blotchiness, uneven skin tone and sun damage. (blogspot.com)
Immature corn kernels2
- Zeatin was discovered in immature corn kernels from the genus Zea. (wikipedia.org)
- Originally derived from RNA in immature corn kernels, Zeatin occurs naturally in plants. (hoodermatology.com)
Purine1
- 6-(γ,γ-Dimethylallylamino)purine is a zeatin precursor. (wikipedia.org)
Dihydrozeatin1
- In enzymology, a zeatin reductase (EC 1.3.1.69) is an enzyme that catalyzes the chemical reaction dihydrozeatin + NADP+ ⇌ {\displaystyle \rightleftharpoons } zeatin + NADPH + H+ Thus, the two substrates of this enzyme are dihydrozeatin and NADP+, whereas its 3 products are zeatin, NADPH, and H+. (wikipedia.org)
Adenine1
- Kinins, such as zeatin, are derived from adenine . (daviddarling.info)
Precursor1
- However, the precursor isopentenyladenosine (IPA) and catabolic product (cis) zeatin-O-glucoside (c-ZOG) were found in small amounts in resting and wound-responding tubers. (usda.gov)
Gene1
- Maize transformants harboring the bean zeatin O-glucosyltransferase (ZOG1) gene driven by the ubiquitin promoter were characterized. (usda.gov)
Corn1
- This poster describes changes in plant growth and development in corn caused by altering the metabolism of zeatin. (usda.gov)
Trans1
- Zeatin has also been shown to promote the resistance of tobacco against the bacterial pathogen Pseudomonas syringae, in which trans-zeatin has a more prominent effect than cis-zeatin. (wikipedia.org)
Promotes1
- Zeatin has a variety of effects including: Promotes callus initiation when combined with auxin, concentration 1 ppm. (wikipedia.org)
Derivatives3
- citation needed] Zeatin and its derivatives occur in many plant extracts and are the active ingredient in coconut milk, which causes plant growth. (wikipedia.org)
- Optimizing the micropropagation protocol for the endangered Aloe polyphylla: can meta-topolin and its derivatives serve as replacement for benzyladenine and zeatin? (cas.cz)
- The use of meta-topolin and its derivatives as alternatives to BA and zeatin, both of which frequently have negative effects in tissue culture was investigated. (cas.cz)
Naturally1
- Naturally occurring zeatin on the other hand is not as widely used as BA and is far more expensive. (cas.cz)
Plants1
- In this study, our aim was to clarify the ameliorative effects of zeatin, a development hormone in plants. (korea.ac.kr)
Product1
- In the tRNA pathway zeatin is a recycled product of isopentenylated tRNAs. (kegg.jp)
Products1
- Kinerase makes other day/night moisturizing products (I believe without the zeatin) available through regular stores such as Sephora also. (blogspot.com)
Growth2
- Zeatin can also be applied to stimulate seed germination and seedling growth. (wikipedia.org)
- Did You Know…that the superfood known as moringa contains several thousand times more of the powerful anti-aging nutrient zeatin than any other known plant-and that it also has 2 compounds that prevent cancer and stop tumor growth ? (bartonpublishing.com)
Levels1
- Transformants had significantly higher levels of the O-glucosides of zeatin and cis-zeatin, and also higher levels of the respective aglycones. (usda.gov)
Results1
- The results showed that zeatin administration attenuated Scop-induced memory damage and decreased AChE activity in the mice. (korea.ac.kr)
Times1
- 5.Spraying 8ppm for 3 times when the blueberries is rosette stage, zeatin can yield increase of 7.13%-16.19%, improve the quality of the blueberries. (agriculture-pesticides.com)
Reductase2
- In enzymology, a zeatin reductase (EC 1.3.1.69) is an enzyme that catalyzes the chemical reaction dihydrozeatin + NADP+ ⇌ {\displaystyle \rightleftharpoons } zeatin + NADPH + H+ Thus, the two substrates of this enzyme are dihydrozeatin and NADP+, whereas its 3 products are zeatin, NADPH, and H+. (wikipedia.org)
- For detailed information about zeatin reductase, go to the full flat file . (brenda-enzymes.info)
Cytokinins1
- The role of cis-zeatin-type cytokinins in plant growth regulation and mediating responses to environmental interactions. (mpg.de)
Seed germination2
- Zeatin can also be applied to stimulate seed germination and seedling growth. (wikipedia.org)
- 1. Cell Division trans-zeatin retards yellowing for vegetable, also applied to stimulate seed germination and seeding growth. (plant-growthregulators.com)
Trans9
- Zeatin has also been shown to promote the resistance of tobacco against the bacterial pathogen Pseudomonas syringae, in which trans-zeatin has a more prominent effect than cis-zeatin. (wikipedia.org)
- U-CHOICE trans-zeatin is 99%TC, very fine crystal powder. (plant-growthregulators.com)
- The process is based on one of Acies Bio's highly efficient microbial platforms with GRAS/QPS status and is expected to lower the cost of trans-zeatin production up to a 100-fold compared to the current production methods. (agropages.com)
- An additional advantage of microbially-produced trans-zeatin is that it is more sustainable than traditional methods of production. (agropages.com)
- The process of producing trans-zeatin through microbial fermentation has several benefits compared to traditional chemical synthesis methods as it diminishes the potential health and safety hazards associated with chemical synthesis. (agropages.com)
- This makes the microbial fermentation process a more environmentally friendly and safer option for trans-zeatin production. (agropages.com)
- In higher plants, zeatin occurs in both the cis and the trans configuration, and these forms can be interconverted by an enzyme known as zeatin isomerase. (bioone.org)
- a. cis-zeatin (cZ) b. trans-zeatin (tZ) c. (plant-biology.com)
- 13. Trans-Zeatin attenuates ultraviolet induced down-regulation of aquaporin-3 in cultured human skin keratinocytes. (nih.gov)
Substance1
- This is how the messenger substance zeatin was discovered, which today is regarded as one of the most important anti-aging substances, because it ensures that many vital substances can only be properly absorbed by the body. (asai.at)
Plant1
- When you transplant tomato, You can scok young-plant root by 0.25ppm zeatin (0.01% zeatin liquid dilute 400 times by water). (plant-growthregulators.com)
Increase4
- Zeatin can increase yield, increase the rate of 6.59%~18.75% Centhance the vitamin centhance. (agriculture-pesticides.com)
- 5.Spraying 8ppm for 3 times when the blueberries is rosette stage, zeatin can yield increase of 7.13%-16.19%, improve the quality of the blueberries. (agriculture-pesticides.com)
- When the corn has 6-8 leaves and 9-10 leaves, we can use zeztin 0.1-0.15ppm to spray twice, (equal 0.01% zeatin liquid dilute 600-1000 times by water), it can help corn have more output, and increase corn weight. (plant-growthregulators.com)
- On bud period, early-flower period, and pod period, we can use zeatin 0.15-0.25ppm to spray, it can increase pod setting ratio, and increase output. (plant-growthregulators.com)
Flower1
- On the bud period, after flower period, young-fruit period and fruit-growth period, you can use zeatin 0.2-0.3ppm to spray, it can help fruit have better color and promote harvest earlier. (plant-growthregulators.com)
High1
- Zeatin is a recently discovered phytohormone that solved the long-coded mystery of why its many valuable constituents are also available to the human body in such high bioavailability. (asai.at)
Form1
- Zeatin is packed maintaining its integrity, ensuring it reaches you in its most potent form, regardless of volume requisitioned. (dubichem.com)