The termination of the cell's ability to carry out vital functions such as metabolism, growth, reproduction, responsiveness, and adaptability.
Factors which produce cessation of all vital bodily functions. They can be analyzed from an epidemiologic viewpoint.
Irreversible cessation of all bodily functions, manifested by absence of spontaneous breathing and total loss of cardiovascular and cerebral functions.
Unexpected rapid natural death due to cardiovascular collapse within one hour of initial symptoms. It is usually caused by the worsening of existing heart diseases. The sudden onset of symptoms, such as CHEST PAIN and CARDIAC ARRHYTHMIAS, particularly VENTRICULAR TACHYCARDIA, can lead to the loss of consciousness and cardiac arrest followed by biological death. (from Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine, 7th ed., 2005)
A state of prolonged irreversible cessation of all brain activity, including lower brain stem function with the complete absence of voluntary movements, responses to stimuli, brain stem reflexes, and spontaneous respirations. Reversible conditions which mimic this clinical state (e.g., sedative overdose, hypothermia, etc.) are excluded prior to making the determination of brain death. (From Adams et al., Principles of Neurology, 6th ed, pp348-9)
Death of the developing young in utero. BIRTH of a dead FETUS is STILLBIRTH.
Conceptual response of the person to the various aspects of death, which are based on individual psychosocial and cultural experience.
A family of intracellular CYSTEINE ENDOPEPTIDASES that play a role in regulating INFLAMMATION and APOPTOSIS. They specifically cleave peptides at a CYSTEINE amino acid that follows an ASPARTIC ACID residue. Caspases are activated by proteolytic cleavage of a precursor form to yield large and small subunits that form the enzyme. Since the cleavage site within precursors matches the specificity of caspases, sequential activation of precursors by activated caspases can occur.
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
A family of cell surface receptors that signal via a conserved domain that extends into the cell CYTOPLASM. The conserved domain is referred to as a death domain due to the fact that many of these receptors are involved in signaling APOPTOSIS. Several DEATH DOMAIN RECEPTOR SIGNALING ADAPTOR PROTEINS can bind to the death domains of the activated receptors and through a complex series of interactions activate apoptotic mediators such as CASPASES.
The span of viability of a cell characterized by the capacity to perform certain functions such as metabolism, growth, reproduction, some form of responsiveness, and adaptability.
Elements of limited time intervals, contributing to particular results or situations.
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
All deaths reported in a given population.
Postmortem examination of the body.
A short pro-domain caspase that plays an effector role in APOPTOSIS. It is activated by INITIATOR CASPASES such as CASPASE 9. Isoforms of this protein exist due to multiple alternative splicing of its MESSENGER RNA.
The pathological process occurring in cells that are dying from irreparable injuries. It is caused by the progressive, uncontrolled action of degradative ENZYMES, leading to MITOCHONDRIAL SWELLING, nuclear flocculation, and cell lysis. It is distinct it from APOPTOSIS, which is a normal, regulated cellular process.
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
Membrane proteins encoded by the BCL-2 GENES and serving as potent inhibitors of cell death by APOPTOSIS. The proteins are found on mitochondrial, microsomal, and NUCLEAR MEMBRANE sites within many cell types. Overexpression of bcl-2 proteins, due to a translocation of the gene, is associated with follicular lymphoma.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
A tumor necrosis factor receptor subtype found in a variety of tissues and on activated LYMPHOCYTES. It has specificity for FAS LIGAND and plays a role in regulation of peripheral immune responses and APOPTOSIS. Multiple isoforms of the protein exist due to multiple ALTERNATIVE SPLICING. The activated receptor signals via a conserved death domain that associates with specific TNF RECEPTOR-ASSOCIATED FACTORS in the CYTOPLASM.
Semiautonomous, self-reproducing organelles that occur in the cytoplasm of all cells of most, but not all, eukaryotes. Each mitochondrion is surrounded by a double limiting membrane. The inner membrane is highly invaginated, and its projections are called cristae. Mitochondria are the sites of the reactions of oxidative phosphorylation, which result in the formation of ATP. They contain distinctive RIBOSOMES, transfer RNAs (RNA, TRANSFER); AMINO ACYL T RNA SYNTHETASES; and elongation and termination factors. Mitochondria depend upon genes within the nucleus of the cells in which they reside for many essential messenger RNAs (RNA, MESSENGER). Mitochondria are believed to have arisen from aerobic bacteria that established a symbiotic relationship with primitive protoeukaryotes. (King & Stansfield, A Dictionary of Genetics, 4th ed)
An infant during the first month after birth.
Splitting the DNA into shorter pieces by endonucleolytic DNA CLEAVAGE at multiple sites. It includes the internucleosomal DNA fragmentation, which along with chromatin condensation, are considered to be the hallmarks of APOPTOSIS.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.
A cell line derived from cultured tumor cells.
Endogenous and exogenous compounds and that either inhibit CASPASES or prevent their activation.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
The segregation and degradation of damaged or unwanted cytoplasmic constituents by autophagic vacuoles (cytolysosomes) composed of LYSOSOMES containing cellular components in the process of digestion; it plays an important role in BIOLOGICAL METAMORPHOSIS of amphibians, in the removal of bone by osteoclasts, and in the degradation of normal cell components in nutritional deficiency states.
An in situ method for detecting areas of DNA which are nicked during APOPTOSIS. Terminal deoxynucleotidyl transferase is used to add labeled dUTP, in a template-independent manner, to the 3 prime OH ends of either single- or double-stranded DNA. The terminal deoxynucleotidyl transferase nick end labeling, or TUNEL, assay labels apoptosis on a single-cell level, making it more sensitive than agarose gel electrophoresis for analysis of DNA FRAGMENTATION.
A long pro-domain caspase that contains a death effector domain in its pro-domain region. Caspase 8 plays a role in APOPTOSIS by cleaving and activating EFFECTOR CASPASES. Activation of this enzyme can occur via the interaction of its N-terminal death effector domain with DEATH DOMAIN RECEPTOR SIGNALING ADAPTOR PROTEINS.
Postnatal deaths from BIRTH to 365 days after birth in a given population. Postneonatal mortality represents deaths between 28 days and 365 days after birth (as defined by National Center for Health Statistics). Neonatal mortality represents deaths from birth to 27 days after birth.
Intracellular signaling adaptor proteins that bind to the cytoplasmic death domain region found on DEATH DOMAIN RECEPTORS. Many of the proteins in this class take part in intracellular signaling from TUMOR NECROSIS FACTOR RECEPTORS.
Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.
A member of the Bcl-2 protein family that reversibly binds MEMBRANES. It is a pro-apoptotic protein that is activated by caspase cleavage.
The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM.
A member of the Bcl-2 protein family and homologous partner of C-BCL-2 PROTO-ONCOGENE PROTEIN. It regulates the release of CYTOCHROME C and APOPTOSIS INDUCING FACTOR from the MITOCHONDRIA. Several isoforms of BCL2-associated X protein occur due to ALTERNATIVE SPLICING of the mRNA for this protein.
A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.
The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.
Molecules or ions formed by the incomplete one-electron reduction of oxygen. These reactive oxygen intermediates include SINGLET OXYGEN; SUPEROXIDES; PEROXIDES; HYDROXYL RADICAL; and HYPOCHLOROUS ACID. They contribute to the microbicidal activity of PHAGOCYTES, regulation of signal transduction and gene expression, and the oxidative damage to NUCLEIC ACIDS; PROTEINS; and LIPIDS.
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
The qualitative or quantitative estimation of the likelihood of adverse effects that may result from exposure to specified health hazards or from the absence of beneficial influences. (Last, Dictionary of Epidemiology, 1988)
Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time.
A long pro-domain caspase that contains a caspase recruitment domain in its pro-domain region. Caspase 9 is activated during cell stress by mitochondria-derived proapoptotic factors and by CARD SIGNALING ADAPTOR PROTEINS such as APOPTOTIC PROTEASE-ACTIVATING FACTOR 1. It activates APOPTOSIS by cleaving and activating EFFECTOR CASPASES.
A transmembrane protein belonging to the tumor necrosis factor superfamily that was originally discovered on cells of the lymphoid-myeloid lineage, including activated T-LYMPHOCYTES and NATURAL KILLER CELLS. It plays an important role in immune homeostasis and cell-mediated toxicity by binding to the FAS RECEPTOR and triggering APOPTOSIS.
Conversion of an inactive form of an enzyme to one possessing metabolic activity. It includes 1, activation by ions (activators); 2, activation by cofactors (coenzymes); and 3, conversion of an enzyme precursor (proenzyme or zymogen) to an active enzyme.
The number of new cases of a given disease during a given period in a specified population. It also is used for the rate at which new events occur in a defined population. It is differentiated from PREVALENCE, which refers to all cases, new or old, in the population at a given time.
Established cell cultures that have the potential to propagate indefinitely.
Inhibitors of SERINE ENDOPEPTIDASES and sulfhydryl group-containing enzymes. They act as alkylating agents and are known to interfere in the translation process.
The killing of one person by another.
NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).
The systems and processes involved in the establishment, support, management, and operation of registers, e.g., disease registers.
The act of killing oneself.
Cytochromes of the c type that are found in eukaryotic MITOCHONDRIA. They serve as redox intermediates that accept electrons from MITOCHONDRIAL ELECTRON TRANSPORT COMPLEX III and transfer them to MITOCHONDRIAL ELECTRON TRANSPORT COMPLEX IV.
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
Maternal deaths resulting from complications of pregnancy and childbirth in a given population.
Exogenous and endogenous compounds which inhibit CYSTEINE ENDOPEPTIDASES.
A nonparametric method of compiling LIFE TABLES or survival tables. It combines calculated probabilities of survival and estimates to allow for observations occurring beyond a measurement threshold, which are assumed to occur randomly. Time intervals are defined as ending each time an event occurs and are therefore unequal. (From Last, A Dictionary of Epidemiology, 1995)
Enzymes that catalyze the transfer of multiple ADP-RIBOSE groups from nicotinamide-adenine dinucleotide (NAD) onto protein targets, thus building up a linear or branched homopolymer of repeating ADP-ribose units i.e., POLY ADENOSINE DIPHOSPHATE RIBOSE.
A member of the bcl-2 protein family that plays a role in the regulation of APOPTOSIS. Two major isoforms of the protein exist due to ALTERNATIVE SPLICING of the BCL2L1 mRNA and are referred to as Bcl-XS and Bcl-XL.
A pro-apoptotic protein and member of the Bcl-2 protein family that is regulated by PHOSPHORYLATION. Unphosphorylated Bad protein inhibits the activity of BCL-XL PROTEIN.
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
The probability that an event will occur. It encompasses a variety of measures of the probability of a generally unfavorable outcome.
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
Damage inflicted on the body as the direct or indirect result of an external force, with or without disruption of structural continuity.
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
An inhibitory T-lymphocyte receptor that has specificity for CD274 ANTIGEN and PROGRAMMED CELL DEATH 1 LIGAND 2 PROTEIN. Signaling by the receptor limits T cell proliferation and INTERFERON GAMMA synthesis. The receptor also may play an essential role in the regulatory pathway that induces PERIPHERAL TOLERANCE.
Based on known statistical data, the number of years which any person of a given age may reasonably expected to live.
The relationship between the dose of an administered drug and the response of the organism to the drug.
Pathological conditions involving the CARDIOVASCULAR SYSTEM including the HEART; the BLOOD VESSELS; or the PERICARDIUM.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
Substances that inhibit or prevent the proliferation of NEOPLASMS.
Tumor necrosis factor receptor family members that are widely expressed and play a role in regulation of peripheral immune responses and APOPTOSIS. The receptors are specific for TNF-RELATED APOPTOSIS-INDUCING LIGAND and signal via conserved death domains that associate with specific TNF RECEPTOR-ASSOCIATED FACTORS in the CYTOPLASM.
A transmembrane-protein belonging to the TNF family of intercellular signaling proteins. It is a widely expressed ligand that activates APOPTOSIS by binding to TNF-RELATED APOPTOSIS-INDUCING LIGAND RECEPTORS. The membrane-bound form of the protein can be cleaved by specific CYSTEINE ENDOPEPTIDASES to form a soluble ligand form.
Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.
Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.
Nuclear phosphoprotein encoded by the p53 gene (GENES, P53) whose normal function is to control CELL PROLIFERATION and APOPTOSIS. A mutant or absent p53 protein has been found in LEUKEMIA; OSTEOSARCOMA; LUNG CANCER; and COLORECTAL CANCER.
Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.
Products of proto-oncogenes. Normally they do not have oncogenic or transforming properties, but are involved in the regulation or differentiation of cell growth. They often have protein kinase activity.
Used for general articles concerning statistics of births, deaths, marriages, etc.
The voltage difference, normally maintained at approximately -180mV, across the INNER MITOCHONDRIAL MEMBRANE, by a net movement of positive charge across the membrane. It is a major component of the PROTON MOTIVE FORCE in MITOCHONDRIA used to drive the synthesis of ATP.
Accidental or deliberate use of a medication or street drug in excess of normal dosage.
Maleness or femaleness as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or effect of a circumstance. It is used with human or animal concepts but should be differentiated from SEX CHARACTERISTICS, anatomical or physiological manifestations of sex, and from SEX DISTRIBUTION, the number of males and females in given circumstances.
The confinement of a patient in a hospital.
Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS.
A set of techniques used when variation in several variables has to be studied simultaneously. In statistics, multivariate analysis is interpreted as any analytic method that allows simultaneous study of two or more dependent variables.
Cell surface receptors that bind TUMOR NECROSIS FACTORS and trigger changes which influence the behavior of cells.
A pathological condition caused by lack of oxygen, manifested in impending or actual cessation of life.
The uptake of naked or purified DNA by CELLS, usually meaning the process as it occurs in eukaryotic cells. It is analogous to bacterial transformation (TRANSFORMATION, BACTERIAL) and both are routinely employed in GENE TRANSFER TECHNIQUES.
A CELL LINE derived from human T-CELL LEUKEMIA and used to determine the mechanism of differential susceptibility to anti-cancer drugs and radiation.
Small double-stranded, non-protein coding RNAs (21-31 nucleotides) involved in GENE SILENCING functions, especially RNA INTERFERENCE (RNAi). Endogenously, siRNAs are generated from dsRNAs (RNA, DOUBLE-STRANDED) by the same ribonuclease, Dicer, that generates miRNAs (MICRORNAS). The perfect match of the siRNAs' antisense strand to their target RNAs mediates RNAi by siRNA-guided RNA cleavage. siRNAs fall into different classes including trans-acting siRNA (tasiRNA), repeat-associated RNA (rasiRNA), small-scan RNA (scnRNA), and Piwi protein-interacting RNA (piRNA) and have different specific gene silencing functions.
Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake.
All of the processes involved in increasing CELL NUMBER including CELL DIVISION.
Ongoing scrutiny of a population (general population, study population, target population, etc.), generally using methods distinguished by their practicability, uniformity, and frequently their rapidity, rather than by complete accuracy.
A strong oxidizing agent used in aqueous solution as a ripening agent, bleach, and topical anti-infective. It is relatively unstable and solutions deteriorate over time unless stabilized by the addition of acetanilide or similar organic materials.
Medical and nursing care of patients in the terminal stage of an illness.
Refers to the whole process of grieving and mourning and is associated with a deep sense of loss and sadness.
A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA or INTRACRANIAL HEMORRHAGES. Stroke is classified by the type of tissue NECROSIS, such as the anatomic location, vasculature involved, etiology, age of the affected individual, and hemorrhagic vs. non-hemorrhagic nature. (From Adams et al., Principles of Neurology, 6th ed, pp777-810)
Drugs intended to prevent damage to the brain or spinal cord from ischemia, stroke, convulsions, or trauma. Some must be administered before the event, but others may be effective for some time after. They act by a variety of mechanisms, but often directly or indirectly minimize the damage produced by endogenous excitatory amino acids.
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.
Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by the abnormalities in HEART RATE, disorders of electrical impulse generation, or impulse conduction.
A family of serine-threonine kinases that plays a role in intracellular signal transduction by interacting with a variety of signaling adaptor proteins such as CRADD SIGNALING ADAPTOR PROTEIN; TNF RECEPTOR-ASSOCIATED FACTOR 2; and TNF RECEPTOR-ASSOCIATED DEATH DOMAIN PROTEIN. Although they were initially described as death domain-binding adaptor proteins, members of this family may contain other protein-binding domains such as those involving caspase activation and recruitment.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN.
Deaths that occur before LIFE EXPECTANCY is reached within a given population.
A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.
Transport proteins that carry specific substances in the blood or across cell membranes.
Injuries to DNA that introduce deviations from its normal, intact structure and which may, if left unrepaired, result in a MUTATION or a block of DNA REPLICATION. These deviations may be caused by physical or chemical agents and occur by natural or unnatural, introduced circumstances. They include the introduction of illegitimate bases during replication or by deamination or other modification of bases; the loss of a base from the DNA backbone leaving an abasic site; single-strand breaks; double strand breaks; and intrastrand (PYRIMIDINE DIMERS) or interstrand crosslinking. Damage can often be repaired (DNA REPAIR). If the damage is extensive, it can induce APOPTOSIS.
Accidents on streets, roads, and highways involving drivers, passengers, pedestrians, or vehicles. Traffic accidents refer to AUTOMOBILES (passenger cars, buses, and trucks), BICYCLING, and MOTORCYCLES but not OFF-ROAD MOTOR VEHICLES; RAILROADS nor snowmobiles.
The process by which chemical compounds provide protection to cells against harmful agents.
Recording of the moment-to-moment electromotive forces of the HEART as projected onto various sites on the body's surface, delineated as a scalar function of time. The recording is monitored by a tracing on slow moving chart paper or by observing it on a cardioscope, which is a CATHODE RAY TUBE DISPLAY.
Glycoproteins found on the membrane or surface of cells.
A multi-domain mitochondrial membrane protein and member of the bcl-2 Protein family. Bak protein interacts with TUMOR SUPPRESSOR PROTEIN P53 and promotes APOPTOSIS.
A protein of the annexin family isolated from human PLACENTA and other tissues. It inhibits cytosolic PHOSPHOLIPASE A2, and displays anticoagulant activity.
An imbalance between myocardial functional requirements and the capacity of the CORONARY VESSELS to supply sufficient blood flow. It is a form of MYOCARDIAL ISCHEMIA (insufficient blood supply to the heart muscle) caused by a decreased capacity of the coronary vessels.
A positive regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.
Death resulting from the presence of a disease in an individual, as shown by a single case report or a limited number of patients. This should be differentiated from DEATH, the physiological cessation of life and from MORTALITY, an epidemiological or statistical concept.
A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
The complex series of phenomena, occurring between the end of one CELL DIVISION and the end of the next, by which cellular material is duplicated and then divided between two daughter cells. The cell cycle includes INTERPHASE, which includes G0 PHASE; G1 PHASE; S PHASE; and G2 PHASE, and CELL DIVISION PHASE.
Proteins which are found in membranes including cellular and intracellular membranes. They consist of two types, peripheral and integral proteins. They include most membrane-associated enzymes, antigenic proteins, transport proteins, and drug, hormone, and lectin receptors.
Disruption of structural continuity of the body as a result of the discharge of firearms.
A 34 kDa signal transducing adaptor protein that associates with TUMOR NECROSIS FACTOR RECEPTOR TYPE 1. It facilitates the recruitment of signaling proteins such as TNF RECEPTOR-ASSOCIATED FACTOR 2 and FAS ASSOCIATED DEATH DOMAIN PROTEIN to the receptor complex.
A condition or physical state produced by the ingestion, injection, inhalation of or exposure to a deleterious agent.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.
A subgroup of mitogen-activated protein kinases that activate TRANSCRIPTION FACTOR AP-1 via the phosphorylation of C-JUN PROTEINS. They are components of intracellular signaling pathways that regulate CELL PROLIFERATION; APOPTOSIS; and CELL DIFFERENTIATION.
The return of a sign, symptom, or disease after a remission.
The fission of a CELL. It includes CYTOKINESIS, when the CYTOPLASM of a cell is divided, and CELL NUCLEUS DIVISION.
The introduction of a phosphoryl group into a compound through the formation of an ester bond between the compound and a phosphorus moiety.
A conserved class of proteins that control APOPTOSIS in both VERTEBRATES and INVERTEBRATES. IAP proteins interact with and inhibit CASPASES, and they function as ANTI-APOPTOTIC PROTEINS. The protein class is defined by an approximately 80-amino acid motif called the baculoviral inhibitor of apoptosis repeat.
A long pro-domain caspase that has specificity for the precursor form of INTERLEUKIN-1BETA. It plays a role in INFLAMMATION by catalytically converting the inactive forms of CYTOKINES such as interleukin-1beta to their active, secreted form. Caspase 1 is referred as interleukin-1beta converting enzyme and is frequently abbreviated ICE.
The first continuously cultured human malignant CELL LINE, derived from the cervical carcinoma of Henrietta Lacks. These cells are used for VIRUS CULTIVATION and antitumor drug screening assays.
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.
A negative regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.
A long pro-domain caspase that contains a caspase recruitment domain in its pro-domain region. Activation of this enzyme can occur via the interaction of its caspase recruitment domain with CARD SIGNALING ADAPTOR PROTEINS. Caspase 2 plays a role in APOPTOSIS by cleaving and activating effector pro-caspases. Several isoforms of this protein exist due to multiple alternative splicing of its MESSENGER RNA.
Pathological conditions involving the HEART including its structural and functional abnormalities.
A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.
The application of pathology to questions of law.
Statistical models which describe the relationship between a qualitative dependent variable (that is, one which can take only certain discrete values, such as the presence or absence of a disease) and an independent variable. A common application is in epidemiology for estimating an individual's risk (probability of a disease) as a function of a given risk factor.
The event that a FETUS is born dead or stillborn.
The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.
Tumors or cancer of the LUNG.
Within a eukaryotic cell, a membrane-limited body which contains chromosomes and one or more nucleoli (CELL NUCLEOLUS). The nuclear membrane consists of a double unit-type membrane which is perforated by a number of pores; the outermost membrane is continuous with the ENDOPLASMIC RETICULUM. A cell may contain more than one nucleus. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)
The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.
Refers to animals in the period of time just after birth.
A short pro-domain caspase that plays an effector role in APOPTOSIS. It is activated by INITIATOR CASPASES such as CASPASE 3 and CASPASE 10. Several isoforms of this protein exist due to multiple alternative splicing of its MESSENGER RNA.
The administrative procedures involved with acquiring TISSUES or organs for TRANSPLANTATION through various programs, systems, or organizations. These procedures include obtaining consent from TISSUE DONORS and arranging for transportation of donated tissues and organs, after TISSUE HARVESTING, to HOSPITALS for processing and transplantation.
Quaternary ammonium analog of ethidium; an intercalating dye with a specific affinity to certain forms of DNA and, used as diiodide, to separate them in density gradients; also forms fluorescent complexes with cholinesterase which it inhibits.
ENDOPEPTIDASES which have a cysteine involved in the catalytic process. This group of enzymes is inactivated by CYSTEINE PROTEINASE INHIBITORS such as CYSTATINS and SULFHYDRYL REAGENTS.
A gene silencing phenomenon whereby specific dsRNAs (RNA, DOUBLE-STRANDED) trigger the degradation of homologous mRNA (RNA, MESSENGER). The specific dsRNAs are processed into SMALL INTERFERING RNA (siRNA) which serves as a guide for cleavage of the homologous mRNA in the RNA-INDUCED SILENCING COMPLEX. DNA METHYLATION may also be triggered during this process.
The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
Ubiquitous, inducible, nuclear transcriptional activator that binds to enhancer elements in many different cell types and is activated by pathogenic stimuli. The NF-kappa B complex is a heterodimer composed of two DNA-binding subunits: NF-kappa B1 and relA.
A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (CORONARY ARTERY DISEASE), to obstruction by a thrombus (CORONARY THROMBOSIS), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (MYOCARDIAL INFARCTION).
The number of CELLS of a specific kind, usually measured per unit volume or area of sample.
Research techniques that focus on study designs and data gathering methods in human and animal populations.
The ratio of two odds. The exposure-odds ratio for case control data is the ratio of the odds in favor of exposure among cases to the odds in favor of exposure among noncases. The disease-odds ratio for a cohort or cross section is the ratio of the odds in favor of disease among the exposed to the odds in favor of disease among the unexposed. The prevalence-odds ratio refers to an odds ratio derived cross-sectionally from studies of prevalent cases.
The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.
Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein.
A CARD signaling adaptor protein that plays a role in the mitochondria-stimulated apoptosis (APOPTOSIS, INTRINSIC PATHWAY). It binds to CYTOCHROME C in the CYTOSOL to form an APOPTOSOMAL PROTEIN COMPLEX and activates INITIATOR CASPASES such as CASPASE 9.
Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.
Procedures for finding the mathematical function which best describes the relationship between a dependent variable and one or more independent variables. In linear regression (see LINEAR MODELS) the relationship is constrained to be a straight line and LEAST-SQUARES ANALYSIS is used to determine the best fit. In logistic regression (see LOGISTIC MODELS) the dependent variable is qualitative rather than continuously variable and LIKELIHOOD FUNCTIONS are used to find the best relationship. In multiple regression, the dependent variable is considered to depend on more than a single independent variable.
Tumors or cancer of the human BREAST.
An indolocarbazole that is a potent PROTEIN KINASE C inhibitor which enhances cAMP-mediated responses in human neuroblastoma cells. (Biochem Biophys Res Commun 1995;214(3):1114-20)
A group of cytochromes with covalent thioether linkages between either or both of the vinyl side chains of protoheme and the protein. (Enzyme Nomenclature, 1992, p539)
Inhaling and exhaling the smoke of burning TOBACCO.
The B-cell leukemia/lymphoma-2 genes, responsible for blocking apoptosis in normal cells, and associated with follicular lymphoma when overexpressed. Overexpression results from the t(14;18) translocation. The human c-bcl-2 gene is located at 18q24 on the long arm of chromosome 18.
Toxic substances from microorganisms, plants or animals that interfere with the functions of the nervous system. Most venoms contain neurotoxic substances. Myotoxins are included in this concept.
Microscopy of specimens stained with fluorescent dye (usually fluorescein isothiocyanate) or of naturally fluorescent materials, which emit light when exposed to ultraviolet or blue light. Immunofluorescence microscopy utilizes antibodies that are labeled with fluorescent dye.
Disease having a short and relatively severe course.
A group of enzymes that catalyzes the phosphorylation of serine or threonine residues in proteins, with ATP or other nucleotides as phosphate donors.
Summarizing techniques used to describe the pattern of mortality and survival in populations. These methods can be applied to the study not only of death, but also of any defined endpoint such as the onset of disease or the occurrence of disease complications.
A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.
Proteins prepared by recombinant DNA technology.
The presence of co-existing or additional diseases with reference to an initial diagnosis or with reference to the index condition that is the subject of study. Comorbidity may affect the ability of affected individuals to function and also their survival; it may be used as a prognostic indicator for length of hospital stay, cost factors, and outcome or survival.
Cysteine proteinase found in many tissues. Hydrolyzes a variety of endogenous proteins including NEUROPEPTIDES; CYTOSKELETAL PROTEINS; proteins from SMOOTH MUSCLE; CARDIAC MUSCLE; liver; platelets; and erythrocytes. Two subclasses having high and low calcium sensitivity are known. Removes Z-discs and M-lines from myofibrils. Activates phosphorylase kinase and cyclic nucleotide-independent protein kinase. This enzyme was formerly listed as EC
A broad category of carrier proteins that play a role in SIGNAL TRANSDUCTION. They generally contain several modular domains, each of which having its own binding activity, and act by forming complexes with other intracellular-signaling molecules. Signal-transducing adaptor proteins lack enzyme activity, however their activity can be modulated by other signal-transducing enzymes
Proteins which bind to DNA. The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases.
A tumor necrosis factor receptor subtype that has specificity for TUMOR NECROSIS FACTOR ALPHA and LYMPHOTOXIN ALPHA. It is constitutively expressed in most tissues and is a key mediator of tumor necrosis factor signaling in the vast majority of cells. The activated receptor signals via a conserved death domain that associates with specific TNF RECEPTOR-ASSOCIATED FACTORS in the CYTOPLASM.
A spectrum of pathological conditions of impaired blood flow in the brain. They can involve vessels (ARTERIES or VEINS) in the CEREBRUM, the CEREBELLUM, and the BRAIN STEM. Major categories include INTRACRANIAL ARTERIOVENOUS MALFORMATIONS; BRAIN ISCHEMIA; CEREBRAL HEMORRHAGE; and others.
Naturally occurring or synthetic substances that inhibit or retard the oxidation of a substance to which it is added. They counteract the harmful and damaging effects of oxidation in animal tissues.
Individuals supplying living tissue, organs, cells, blood or blood components for transfer or transplantation to histocompatible recipients.
Number of deaths of children between one year of age to 12 years of age in a given population.
A distribution in which a variable is distributed like the sum of the squares of any given independent random variable, each of which has a normal distribution with mean of zero and variance of one. The chi-square test is a statistical test based on comparison of a test statistic to a chi-square distribution. The oldest of these tests are used to detect whether two or more population distributions differ from one another.
Connective tissue cells which secrete an extracellular matrix rich in collagen and other macromolecules.
High molecular weight proteins found in the MICROTUBULES of the cytoskeletal system. Under certain conditions they are required for TUBULIN assembly into the microtubules and stabilize the assembled microtubules.
Normal, appropriate sorrowful response to an immediate cause. It is self-limiting and gradually subsides within a reasonable time.
Deaths occurring from the 28th week of GESTATION to the 28th day after birth in a given population.
A protein-serine-threonine kinase that is activated by PHOSPHORYLATION in response to GROWTH FACTORS or INSULIN. It plays a major role in cell metabolism, growth, and survival as a core component of SIGNAL TRANSDUCTION. Three isoforms have been described in mammalian cells.
Divisions of the year according to some regularly recurrent phenomena usually astronomical or climatic. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
Heart Diseases Causes Sudden Death at an Early Hour Thursday Morning. WIDELY KNOWN HERE. Chairman of Legislative Committee of ... Shortly after his death, the Nashville Trades and Labor Council passed a resolution in his honor. 1900 United States Federal ... Tennessee, Death Records, 1908-1958 "Tennessee House of Representatives 52nd General Assembly". Tennessee State Capitol. ... Census "DEATH OF CHAS. P. FAHEY". The Leather Workers' Journal. 16-17: 238-239. 1913. Retrieved December 21, 2017. "CHARLES P. ...
Charlotte's death was widely mourned. William married for the fourth and final time on 12 April 1583 to Louise de Coligny, a ... The second arms he used most of his life from the time he became Prince of Orange on the death of his cousin René of Châlon. He ... Before her death Willem had already announced his third marriage, which drew the disapproval of her family who argued that, ... This youngest of William's children, who was born only a few months before William's death, was to be the only one of his sons ...
Sichone's death was widely mourned. The civil society movement tried to petition the government to accord her a state funeral ... After the death of her husband she experienced what is called "property grabbing," a practice which is still very common in ... She wrote, "The freedoms enshrined in the Bill of Rights make it a sacred duty for me to defend them to the death." She ended ... Ten years after the death of her first husband, Shichone married her second husband. Lucy Sichone represented so many clients ...
Schober's death came a mere three weeks after the death of Ignaz Seipel, who had also been struggling with long illness. The ... coincidence was widely noted. The two former enemies had reconciled during their final days, conveying best wishes to each ... His death was not unexpected. Schober had been suffering from heart disease; his condition had noticeably worsened during his ... holding both positions until his death. He served as the chancellor of Austria from June 1921 to May 1922 and again from ...
Charlotte's death was widely mourned. Following her death, William married on 24 April 1583, his fourth and last wife, Louise ... This plan was carried out upon the aunt's death, against Charlotte's wishes, and despite her being only 12. While abbess, ...
Lyuh's death was widely mourned. 1886 May 25 - Born in Yangpyeong Yangseo-myeun Shingok-ri (now Shinwon-ri) Myogok (妙谷), ...
Ngetich's death was widely reported; the race organizers didn't give a "No. 1" bib to any of the runners in honor of the past ...
After Grace's death, the house was left to the Columbus Foundation. They lease it to the Junior League of Columbus, who ... Her work was widely recognized; along with other members of AID, she consulted on the Jacqueline Kennedy redecoration of the ... She lived there until her death in 1975. Grace was one of the first people in the country to make her living as an interior ...
7 FAM 200 Appendix E: Death with Dignity. US Department of State Foreign Affairs Manual, Volume 7. "Between life and death for ... "Euthanasia: Widely debated, rarely approved". The Times of India. 8 March 2011. Archived from the original on 5 November 2012. ... Jains and Hindus have the traditional rituals Santhara and Prayopavesa respectively, wherein one fasts unto death. The Jain vow ... "After 36 yrs of immobility, a fresh hope of death". Indian Express. 17 December 2009. Retrieved 7 March 2011. "India court ...
The Jews were required, however, to pay to the king a new impost, the "goldene Opferpfennig." During the Black Death (1349) the ... widely known as a preacher; died in 1597. The Maharal of Prague, delivered the funeral oration.[citation needed] Simon of ... Aschaffenburg), author of a supercommentary to Rashi's Pentateuch commentary; lived at Frankfurt until his death.[citation ... prepared for death, and thought themselves fortunate when they were permitted to leave the city through the Fischerfeld gate on ...
The pupils are widely dilated. As death approaches, the convulsions follow one another with increased rapidity, severity, and ... Death occurs as a result of respiratory arrest. The clinical signs of strychnine poisoning relate to its effects on the central ... With a very high dose, the onset of respiratory failure and brain death can occur in 15 to 30 minutes. If a lower dose is ... Death results from asphyxia due to prolonged paralysis of the respiratory muscles. Following the ingestion of strychnine, ...
His death was widely mourned. (812 South St. - 1992) Robert Mara Adger (1837-1910) - Businessman, activist, bibliophile lived ... He was Bing Crosby's accompanist when death cut short Lang's career in 1933. (S. 7th St. just N. of Clymer St. - 1995) Mario ...
It is widely thought[who?], however, that the Soviet leadership is dissatisfied with his performance and wants to create a ... the reported death toll is 200. 700 resistance fighters are killed in Paktia province. Karmal resigns as general secretary of ...
He traveled widely in Europe, frequently finding work as a stage designer. Thieme traveled to the United States at the age of ... The circumstances of his death are not fully understood. There have been stories of deep depression or major illness, but no ... He continued to travel widely; Mexico, Guatemala, Florida, and France were major destinations, always painting en plein air. ...
The epigrams have been widely quoted. He remained at Yale until his death in 1990. Publications, a selection: 1957. Internal ...
Death rates varied widely by province. While in Bitlis and Trabizond 99% of the Armenian population vanished from the ... Deportation amounted to a death sentence; the authorities planned for and intended the death of the deportees. Deportation was ... The atrocities were widely covered in Western newspapers and condemned by world leaders such as Woodrow Wilson, David Lloyd ... Before World War II, the Armenian Genocide was widely considered the greatest atrocity in history. As of 2021[update], 30 ...
In 1937 he wrote (with R. Ernest Dupuy) the widely cited "If War Comes." In 1938 he wrote "The ramparts we watch," a widely ... Social Security Death Index [database on-line]. "George Eliot, 22 June 1894 - April 1971."(Subscription). Provo, UT, USA: ... Social Security Death Index, Master File. Social Security Administration. Retrieved 24 February 2010. [9]"Mrs. George F. Eliot ... Retrieved 13 March 2010 Biography for George F. Eliot at IMDb Has 22 April 1971 as death date, which contradicts his obituary ...
Estimated death tolls also vary widely. Contemporary studies conducted by John Lossing Buck allege that at least 150,000 people ... Fatality estimates vary widely. A field survey by the University of Nanking led by John Lossing Buck immediately after the ... Some Western sources allege that the death toll of between 3.7 and 4 million people based on their own claims of famine and ... They sit stoically awaiting death." In 1953, after the end of the Chinese Civil War, Chinese Communist Party leader Mao Zedong ...
He travelled widely on several circuits; and was President of the Methodist Church in Ireland during 1929: his father had also ... Deaths. The Times (London, England), Monday, Jan 19, 1931; pg. 1; Issue 45724 'ROBERTSON, Rev. John Charles', Who Was Who, A & ...
As with all non-lethal or less-lethal weapons, there is some risk of serious permanent injury or death when tear gas is used. ... CS is the most widely used. CN has the most recorded toxicity. Typical manufacturer warnings on tear gas cartridges state " ... and death, especially in cases with exposure to high concentrations of tear gas or application of the tear gases in enclosed ... resulting in immediate death. A case of serious vascular injury from tear gas shells has also been reported from Iran, with ...
Julius is widely considered a martyr. L. Arik Greenberg: My Share of God's Reward. Exploring the Roles and Formulations of the ... Julius declined the offer and was sentenced to death. Julius was killed by the sword in Durostorum, the Roman camp in Moesia ...
His story was not widely trusted. The public was shocked upon hearing about Lumumba's death. Soon thereafter it became known ... International observers reported the deaths of hundreds of Baluba on 29 and 30 August. Colonel Mobutu ended the campaign on 1 ... On the international level, the announcement of Lumumba's death led several Eastern Bloc and African states to declare that ... ISBN 978-3-11-150469-8. Gerard, Emmanuel; Kuklick, Bruce (2015). Death in the Congo: Murdering Patrice Lumumba. Cambridge, MA: ...
Black Mamba was not widely screened. The film was released in the Philippines but not the US. A person bought it and took it to ... The film remained unreleased until after Ashley's death in 1997. Lamont, John (1992). "The John Ashley Interview Part 2". Trash ...
They toured widely in 2011. In 2010 they released their debut album, Atrocities, and in 2016 followed with The Cold Expanse. ... A reviewer, writing as "Robert in Death" on The Sonic Sensory, wrote on 20 June 2016 of The Cold Expanse: "... this five-piece ... Anno Domini are an Australian symphonic black, death metal band. Formed in 2005, the band's line-up as from 2016 was Michael ... CS1 maint: discouraged parameter (link) Review of The Cold Expanse "Robert in Death" at The Sonic Sensory 20 June 2016, ...
Kosenko's diagnosis was widely criticized. Russian psychiatrist Andrey Bilzho called it "the death of psychiatry." Yuri Savenko ... Kosenko's verdict and sentence were widely condemned as a political abuse of psychiatry, marking a return to the Soviet Union ... learned of his mother's death through the media and was not allowed to attend her funeral in September 2013. Kosenko's verdict ...
Todesmärsche - "Death marches" - at the end of the war when it became obvious that the German army was trapped between the ... It was not well organized or widely effective, and there were only a few known instances of involvement, mainly after the war ... After Wever's death in 1936, the program was shelved. Urlaub - furlough; also: vacation. Utof (Uboots-Torpedoboots- ... SS-TV - SS-Totenkopfverbände (SS Death's Head Units). SS-Verfügungstruppen - "units available" or military formations of the SS ...
Estimates of worldwide deaths vary widely depending on source, ranging from 1 million to 4 million. The Hong Kong flu was a ... Those over 65 had the greatest death rates. In the US, there were about 100,000 deaths. The 1977 Russian flu was a relatively ... that included 6,071 deaths." By the end of the pandemic, there were more than 18,000 laboratory-confirmed deaths from H1N1. Due ... and may have killed as many people as the Black Death, although the Black Death is estimated to have killed over a fifth of the ...
Her death was widely mourned throughout Japan. The major tv networks had cancelled most of their regular programming that day ... This claim spread around widely. After her death in 1989, author Rō Takenaka and journalist Tsukasa Yoshida investigated ... After Hibari's death in 1989, a TBS television drama special aired in the same year by the name of The Hibari Misora Story (美空ひ ... to bring the news of her death and aired various tributes. Beginning in 1990, television and radio stations annually play her ...
Demanding the death penalty, Nikam told the court, "The accused are sex-starved goons in shape of humans. They deserve maximum ... I won't speak against Islam." Azmi's comments were widely criticized in India. 2012 Delhi gang rape 2014 Badaun gang rape Rape ... Awarding the death penalty, the judge stated, "Mumbai gang-rape accused have least respect for law. They don't have potential ... But, at times, the wrong people are awarded the death penalty. Boys do it in josh (Hindi: excitement), but what can I say in ...
At his death, Messager left some numbers for an unfinished work, Sacha, to a libretto by Maurice Donnay, André Rivoire and Léon ... Others whose verse he set ranged widely, from Victor Hugo to Frederic Weatherly (author of among other things "Danny Boy"). In ... By the time of her death in 1892 the two had become close again, and Messager felt her loss deeply. In 1892 Messager's career ... Harding suggests that the unusual seriousness of the score may be connected with the recent illness and death of Edith Messager ...
As to the fate of the princes, it is widely held that Richard III ordered the death of his two nephews to secure his own reign ... After Elizabeth's death in 1503, Margaret became the principal female presence at court. When the death of Prince Arthur ... Following Edward's death and the seizure of the throne by Richard, Margaret was soon back at court serving the new queen, Anne ... According to Thomas Basin, Somerset died of illness, but the Crowland Chronicle reported that his death was a suicide. As his ...
Today it is widely known which dogs carried the disease and respectable breeders do not use those bloodlines any more. A health ... William Wordsworth's poem "Fidelity" was written after the death of Charles Gough, who fell from Striding Edge, Helvellyn in ... with the first Pat after the dog's death.[3] ...
After his death, his second son, Henry V, reached an agreement with the Pope and the bishops in the 1122 Concordat of Worms.[56 ... Overall population figures for the Holy Roman Empire are extremely vague and vary widely. The empire of Charlemagne may have ... Upon Henry the Fowler's death, Otto, his son and designated successor,[50] was elected King in Aachen in 936.[51]:706 He ... Upon Louis' death in 840, it passed to his son Lothair, who had been his co-ruler. By this point the territory of Charlemagne ...
"Not With a Bang, But a Whimper: The Long, Slow Death Spiral of America's Labor Movement". The New Republic. 6 June 2012. ... The multitudes who compose the working class are too numerous and too widely scattered to combine at all, much more to combine ... An ILO mission in 2000 reported that "the number of assassinations, abductions, death threats and other violent assaults on ... Although their political structure and autonomy varies widely, union leaderships are usually formed through democratic ...
The formula has been widely used in Asian LNG SPAs, where base price represents various non-oil factors, but usually a constant ... LNG tankers have sailed over 100 million miles without a shipboard death or even a major accident.[119] ...
The type that is widely used and created by Merck is indinavir sulfate. The pills are created from sulfate salts and are sold ... The end point of the study was death or development of opportunistic infections.[13] ...
... a widely used[21] definition devised by the US NCCIH calls it "a group of diverse medical and health care systems, practices, ... Lack of evidence for effectiveness.[77] Unwanted outcomes, such as death and disability, "have occurred when faith healing was ... Regulation and licensing of alternative medicine ranges widely from country to country, and state to state.[152] In Austria and ... Australia regarding a patient who almost bled to death on the operating table after neglecting to mention that she had been ...
"Life and Death in the Field , Final Straw - Food , Earth , Happiness". Retrieved 2017-04-16.. .mw-parser- ... Widely regarded as the leading practitioner of the second-generation of natural farmers, Yoshikazu Kawaguchi is the instigator ... his philosophy and the governing principles of his farming systems have been applied widely around the world, from Africa to ... the methods themselves vary widely depending on culture and local conditions. ...
... the most widely accepted estimates of excess deaths under the Khmer Rouge range from 1.5 million to 2 million, although figures ... Heuveline's central estimate is 2.52 million excess deaths, of which 1.4 million were the direct result of violence.[313][315] ... Pol Pot had grown suspicious of Son Sen and in June 1997 ordered his death. Khmer Rouge cadres subsequently killed Son and 13 ... The idea that the deaths which occurred under Pol Pot's government should be considered genocide was first put forward by the ...
Mookherjee's death later compelled Nehru to remove Permit system, post of Sadar-e-Riayasat and of Prime Minister of Jammu & ... He has been widely acclaimed the "Father of Indian unrest" who used the press and Hindu occasions like Ganesh Chaturthi and ... His death led the revolutionaries like Chandrashekar Azad and Bhagat Singh to kill the British officer J. P. Saunders, who they ... Though Mukherjee was not associated with RSS, he is widely revered by members and supporters of the RSS and the Vishwa Hindu ...
Considered by music authorities as the co-founder of Western swing,[1][2][3] he was widely known as the King of Western Swing ( ... He lingered until his death on May 13, 1975. In addition to being inducted into the Country Music Hall of Fame in 1968,[52] ... He was recording an album with fan Merle Haggard in 1973 when a stroke left him comatose until his death in 1975. The Rock and ... From 1974 until his 2002 death, Waylon Jennings performed a song he had written called "Bob Wills Is Still The King". Released ...
It is widely celebrated by the country's large Azerbaijani minority (~7% of the total population)[112] as well as by the ... leading to several deaths and mass arrests.[122] The government has stated that the Newroz celebrations will be tolerated as ... Nauruz is celebrated widely in Afghanistan. Also known as the Farmer's Day, the observances usually last two weeks, culminating ...
Sepsis is caused by overwhelming response to an infection and leads to tissue damage, organ failure, and even death. The ... as was widely believed at the time, but DNA.[13] Avery's work marked the birth of the molecular era of genetics.[14] ...
Death[edit]. On December 28, 2009, The Rev was found unresponsive in his Huntington Beach home, and was later pronounced dead ... The Rev was widely regarded and critically acclaimed for his work on the band's albums, and contributed entire songs composed ... which The Rev had written three days before his death.[12][13] M. Shadows and Gates stated in an interview to Hard Drive Radio ... "Death." And it was the last song The Rev wrote for the album, and when he handed it in, he said, 'That's it, that's the last ...
... was beaten to death, reportedly by other inmates and by the labor supervisor.[26] Zhang's death, along with the March 2003 ... The facilities have been widely criticized for the physical abuse that is said to go on within them. Corporal punishment is ... The prominent deaths of two inmates in spring 2003 prompted many calls within China for reform of the system, but reform did ... which has not been widely practiced since the 1990s;[10] and "shelter and investigation," a system of detentions for ...
Work Table I. Deaths from each cause by 5-year age groups, race and sex: US, 1999 Page 1922. U.S. Centers for Disease Control ... The drugs oxymetazoline or phenylephrine are widely available in over-the-counter nasal sprays for the treatment of allergic ... Envenomation by mambas, taipans, kraits, and death adders. *Chronic liver disease-cirrhosis causes deficiency of factor II, VII ... accounting for only 4 of the 2.4 million deaths in the U.S. in 1999.[2] About 60% of people have a nosebleed at some point in ...
CD20 is widely expressed on B cells, from early pre-B cells to later in differentiation, but it is absent on terminally ... Reactivation of the JC virus usually results in death or severe brain damage.[32] ... and rituximab is widely used off-label to treat difficult cases of multiple sclerosis,[15] systemic lupus erythematosus, ... When it binds to this protein it triggers cell death.[2] ... Serious adverse events, which can cause death and disability, ...
It is the major source of late treatment-related complications, although it less often results in death. In addition to ... Prognosis in HSCT varies widely dependent upon disease type, stage, stem cell source, HLA-matched status (for allogeneic HSCT) ...
CTG monitoring is widely used to assess fetal wellbeing. A review found that in the antenatal period (before labour) there is ... The same review found that computerised CTG machines resulted in lower numbers of baby deaths than the traditional CTG machines ... stress reactions and other effects should be investigated before this technique is used widely. External cardiotocography can ...
Forbes, Robert James (1970). A Short History of the Art of Distillation: From the Beginnings up to the Death of Cellier ... Alcohol is one of the most widely used recreational drugs in the world, with about 33% of people being current drinkers.[4] As ... "Just 40ml liquor daily may even put you at death risk: Report". 2020-06-15. Retrieved 2020-06-15.. ... In higher doses, it causes drunkenness, stupor, unconsciousness, or death. Long-term use can lead to alcohol abuse, cancer, ...
This causes death by respiratory failure leading to cerebral anoxia. No antidote is known, but if breathing can be kept going ... This claim was widely disbelieved until the 19th century. It was described in 1829 by the French zoologist Georges Cuvier, who ... exposure of muscle and death of octopuses in extreme cases.[107] ... "Hormonal Inhibition of Feeding and Death in Octopus: Control ...
The net effect is that the time to complete the cell cycle varies widely over the cells in a population even when they all are ... "Aging and Death in an Organism That Reproduces by Morphologically Symmetric Division". PLOS Biology. 3 (2): e45. doi:10.1371/ ... Caulobacter crescentus is a Gram-negative, oligotrophic bacterium widely distributed in fresh water lakes and streams. The ... The proteins of the Caulobacter cell cycle control system are widely co-conserved across the alphaproteobacteria, but the ...
The company's anti-open-source sentiment was enforced by former CEO Steve Ballmer, who referred to Linux, a widely-used open- ... features such as alerting health care workers when patients show warning signs for conditions and records births and deaths ...
lit. 'One Man's Death', this from the Danish business expression "One man's death, another man's bread" (Danish: Den Enes Død, ... He dies early on from a heart attack, but is widely reported to have killed himself with either a duelling gun or gas. The fate ... Fernando Møhges death, that he is the bastard child of the late Fernando Møhge and thus half-brother to Misse Møhge. ... Vinther's and working as a debt collector until his death. Even though it is never clearly stated in the series, he is a ...
Only in death does duty end (talk) 11:17, 29 November 2017 (UTC). I see. So pairs like MOS:LEAD and WP:LEAD, which both point ... Pretty much every style guide gives a conflicting "rule" about this, with widely divergent rationales (when one is offered at ... Only in death does duty end (talk) 08:06, 29 November 2017 (UTC) That definitely doesn't make any sense. We should pick one ...
However, experiments have had limited success in demonstrating a definition of learning that is widely agreed upon. ... and continuing until culture death. They gathered network burst profiles (BPs) through a mathematical observation of array-wide ...
... es emit widely on the acoustics spectrum and the sounds are caused by multiple mechanisms. Various sounds of tornadoes ... "Overpasses are tornado death traps". USA Today. Archived from the original on 2005-04-08. Retrieved 2007-02-28 ... Although this is a widely accepted theory for how most tornadoes form, live, and die, it does not explain the formation of ... This belief is partly inspired by widely circulated video captured during the 1991 tornado outbreak near Andover, Kansas, where ...
... including sudden death[5]) will outweigh the risks of not treating the symptom of short stature. Although short children ... as the widely abundant statistics from these countries clearly state) is about 179 centimetres (5 ft 10 in) for men and 166 ...
UK Health Secretary: The smoking ban "is a huge step forward for public health and will help reduce deaths from cancer, heart ... though this approach has not been widely adopted in the U.S. because "in the end, it is simpler, cheaper, and healthier to end ... The Prime Minister lamented the smoking death rate in the country with 400,000 citizens dying every year of smoking-related ... regarded as one of the major public health hazards and is responsible directly or indirectly for an estimated eight lakh deaths ...
If evolution possessed an active trend toward complexity (orthogenesis), as was widely believed in the 19th century,[12] then ...
As high as death rates are in some models, the average rate for all vehicles is going down over time. The average driver death ... Death rates generally are lower in bigger vehicles. An exception is large station wagons with a driver death rate (99) thats ... Death rates by vehicle size and weight. Characteristics that influence vehicles death rates include type and body style (2- ... 4 , SPECIAL ISSUE: DRIVER DEATH RATES , April 19, 2007 Subscribe. Driver deaths by make and modelFatality risk in 1 vehicle ...
Car, minivan, SUV, and pickup truck models vary widely in the likelihood of dying in a crash. The average driver death rate in ... How the death rates were computed. Rates of driver death in all crashes plus rates in multiple-vehicle, single-vehicle, and ... 3 , SPECIAL ISSUE: DRIVER DEATH RATES , March 19, 2005 Subscribe. Fatality risk isnt the same in all vehicles, driver death ... The model with the highest death rate of all - the two-door, two-wheel-drive Chevrolet Blazer with 308 driver deaths per ...
Reuters Health) - Heart disease death rates vary substantially at Veterans Affairs hospitals nationwide, and a new study ... At the various locations, annual death rates for heart disease ranged from a low of 5.5 percent to a high of 9.4 percent, while ... Previous research has long documented differences in death rates at hospitals across the U.S., not just at VA facilities, often ... These patients with multiple chronic health problems have a high risk of serious complications and death. Its not clear from ...
home/cancer center/ cancer a-z list/ diabetes drug may reduce cancer death risk article ... "Our findings suggest that diabetes remains a risk factor for cancer and cancer-related death, and metformin therapy, compared ...
Procedures for determining brain death in 41 U.S. hospitals vary widely and most deviate significantly from practice guidelines ... "Brain death is considered a legal definition of death, and inappropriately labeling a patient as dead by brain criteria could ... There was also wide variation in the specialists allowed to declare brain death. In 36% of responding hospitals, a primary ... They said the findings may call into question the accuracy of brain-death determinations across institutions. "Although there ...
Death rates at Bay Area hospitals vary widely,… Share this:. *Click to share on Facebook (Opens in new window) ... They adjusted the death rates to take into account such risk factors as a patients age and other health problems, then ... OConnor Hospital in San Jose had a 7.1 percent death rate for pneumonia patients in 2011, compared to a state average of 4.1 ... Doctors Medical Center in San Pablo had a death rate of 2.4 percent - well below the state average of 6.5 percent. ...
... burst into the public consciousness in June when a British clinical trial found it cut the risk of death by about a third for ... Cheap, widely available steroids significantly reduce the risk of death for severely ill COVID-19 patients, according to a new ... Cheap, widely available steroids significantly reduce the risk of death for severely ill COVID-19 patients. ... when a British clinical trial found it cut the risk of death by about a third for COVID-19 patients on mechanical ventilators. ...
A low cost and widely available drug could reduce deaths in traumatic brain injury patients by as much as 20 per cent depending ... A low cost and widely available drug could reduce deaths in traumatic brain injury patients by as much as 20 per cent depending ... Global trial is first clear evidence that a widely available drug reduces head injury deaths. ... It found that administration of TXA within three hours of injury reduced the number of deaths. This effect was greatest in ...
Cocaine-related overdose deaths among blacks are on par with fatal overdoses caused by heroin and prescription opioids among ... Widely available drugs. "Drug poisoning deaths can be classified as unintentional, suicide, homicide or undetermined intent," ... Cocaine deaths among blacks on par with opioid deaths among whites, study finds. By Susan Scutti, CNN ... Cocaine-related overdose deaths among non-Hispanic blacks are on par with overdose deaths caused by heroin and prescription ...
Turkish rescue workers search for survivors in quake; death toll rises to 27. ... Moodys - Fiscal resilience of Europes regional and local governments varies widely amid Coronavirus crisis. Read full article ... regional and local governments varies widely amid Coronavirus crisis,/b,,/p, ,p style=position:absolute;top:216px;left:108px; ...
The consumer revolt against neonicotinoids, widely blamed for the decline in pollinators, has been swift and surprisingly ... New statistics on death rates in the United States appear to confirm a grim prediction - that obesity is reversing decades of ... Fears weed killer decision a death knell for reef - ABC News (Australian Broadcasting Corporation) ...
... to reduce the death toll from overdoses involving prescription painkillers. ... Naloxone can reverse heroin overdose, but its not widely available. *. Doctors are top source of prescription drugs for ... With deaths attributed to opioid drug overdose continuing to rise, the FDA has approved a device that would allow an at-home ... With deaths attributed to opioid drug overdose continuing to rise, the FDA has approved a device that would allow an at-home ...
NFA] The number of U.S. coronavirus deaths exceeded 130,000 on Monday, following a surge of new cases that has put President ... U.S. tops 130K virus deaths; states halt reopening. Posted [NFA] The number of U.S. coronavirus deaths exceeded 130,000 on ...
... only reduce patient death rates in the short term. ... Childbirth Complications Vary Widely at US Hospitals: Study. ... Centralizing Stroke Services can Reduce Deaths in Hospital. Centralising acute stroke services can reduce mortality and length ... Our latest research shows that in the longer-term, although death rates in the North West continued to fall, the reductions for ... Previous research conducted at The University of Manchester showed Advancing Quality to have reduced patient deaths by 890 in ...
From the first deaths in February, as President Trump still predicted none, the U.S. has reached 100,000 lives lost to the ... Success varied widely. As hospitalizations and deaths accelerated, Trump veered from claiming absolute authority to telling ... The U.S. death toll from the coronavirus has now surpassed American deaths from World War I. Heres a look at COVID-19s place ... from his early denials of a problem and promise of zero deaths to his erratic stewardship of the response once the death count ...
Growing numbers of emergency room visits, hospitalizations and deaths have followed as grim consequences. ... Fauci optimistic COVID-19 vaccine will be widely available National and World News ...
Suspect in Ashanti Billies kidnapping death found not competent to stand trial ... an issue that has divided urban and rural schools and yielded widely varying guidance. ...
Americas Most Widely Misread Literary Work * Jackie Lay *. The Double-Consciousness of a Dark Body * Tynesha Foreman ... Death at an Early Age. Countless sociological studies and official reports have described the dreadful condition of the ... This article was excerpted from Jonathan Kozols book Death at an Early Age. ...
Widely Available. *Electronic health (medical) records. Exploratory. *Linking electronic health records and claims ...
As this collaboration continues, and the products of this work are disseminated widely, stakeholder organizations and the ... Modernizing Death Reportingplus icon *Improving Data on Drug Overdose Deaths. *Understanding Death Data ...
Colorado Leaders Mourn The Death Of Justice Ruth Bader Ginsburg. By Colorado Public Radio Staff ...
Minneapolis Police Face Civil Rights Probe Over Floyd Death Widely seen bystander video showing Floyds death has sparked ... Widely seen bystander video showing Floyds death has sparked sometimes violent protests around the world. The officer, Derek ... "The cause of death was that he was starving for air. It was lack of oxygen. And so everything else is a red herring to try to ... Earlier Tuesday, an attorney for Floyds family again decried the official autopsy that found his death was caused by cardiac ...
As Opioid Deaths Rise, an 8th State Declares a Disaster. 5 days ago ... Quality of Community Health Centers Varies Widely Community health centers in New Hampshire were the most likely to keep ... But like the care given in doctors offices, the centers performance varies widely -- with some excelling in some areas while ...
The actual cause of his death: whether it was from disease or poisoning. The poisoning hypothesis is widely discredited. If a ... Some ascribe Mozarts death to malpractice on the part of his physician, Dr. Closset. His sister-in-law Sophie Weber, in her ... The widely repeated claim that, on his deathbed, Mozart dictated passages of the Requiem to his pupil Süssmayr is strongly ... The night of Mozarts death was dark and stormy ; at the funeral, too, it began to rage and storm. Rain and snow fell at the ...
But a paper shared widely online claimed that vaccines cause two deaths for every three lives saved. Experts say the analysis ...
Kern County Public Health reports 1 new COVID-19 death, 56 cases ... When will COVID-19 vaccines be widely available globally? World ... WASHINGTON (AP) - When will COVID-19 vaccines be widely available globally?. Experts say it could be 2023 or later before the ... When will COVID-19 vaccines be widely available globally? (AP Illustration/Peter Hamlin) ... shots are widely available in some countries.. The United States, Israel and the United Kingdom are among the nations where ...
This must be widely implemented. Third, the thoughtful and judicious use of antibiotics in patients with bacterial and ... Influenza-associated deaths among children in the United States, 2003-2004. N Engl J Med. 2005;353(24):2559-2567pmid:16354892. ... Influenza-associated pediatric deaths in the United States, 2004-2012. Pediatrics. 2013;132(5):796-804pmid:24167165. ... Influenza-associated pediatric deaths in the United States, 2010-2015. Online J Public Health Inform. 2017;9(1):e077. ...
... and widely disseminated by all. Please feel free to lay in over at Ars with any links you might have, or stick them here and ... 1,088 deaths /22 years = say 50 deaths per year, or a little less than one death per week. ... There is nothing a parent can experience that is more traumatic than the death of a child. But, when a death tragically occurs ... The anti-vaxxers quoted are, if I am not mistaken, asserting 217 deaths per year, which ends up indeed being 1 death per 40 ...
His death was widely reported:. Of late years Mr. Ross had been in very bad circumstances, and his poverty at last seems to ...
  • Car, minivan, SUV, and pickup truck models vary widely in the likelihood of dying in a crash. (
  • Procedures for determining brain death in 41 U.S. hospitals vary widely and most deviate significantly from practice guidelines issued by the American Academy of Neurology, reported David M. Greer, M.D., of Massachusetts General Hospital, and colleagues online in Neurology . (
  • The trends in overdose deaths vary widely across the country. (
  • Will vary widely between farms. (
  • Currently, five states have digital assets laws, which vary widely. (
  • The new study , published on Wednesday in JAMA, pooled data from the British trial and six other clinical trials - including one with Canadian sites - and confirmed that dexamethasone did indeed cut the risk of death substantially for coronavirus patients in the intensive-care unit, even those who did not require invasive ventilation. (
  • NFA] The number of U.S. coronavirus deaths exceeded 130,000 on Monday, following a surge of new cases that has put President Donald Trump's handling of the crisis under the microscope. (
  • The nation's coronavirus death toll surpassed 100,000 in less than four months on Wednesday, a heart-rending inflection point in a pandemic that has profoundly altered Americans' daily lives, ravaged the U.S. economy and put the country's bare-knuckle political disunity on display for all the world to see. (
  • The first U.S. death was reported Feb. 29, a patient in the Seattle area, but several earlier fatalities - not attributed at the time to COVID-19, the illness caused by the coronavirus - have since come to light. (
  • As the Trump administration ignores the pleas of its own health experts and embraces a "herd immunity" strategy that scientists have condemned as fringe and dangerous , researchers at the University of Washington School of Medicine are predicting an 80% spike in U.S. coronavirus deaths by February as cases continue to rise across the nation. (
  • A model designed by experts at the Institute for Health Metrics and Evaluation forecasts that the U.S. coronavirus death toll will soar from around 217,000 at present to 389,087 fatalities by February 1. (
  • Cocaine-related overdose deaths among non-Hispanic blacks are on par with overdose deaths caused by heroin and prescription opioids among whites, according to a study published Monday in the medical journal Annals of Internal Medicine. (
  • But the new study reveals the increasing rates of drug overdose deaths among black and Hispanic Americans. (
  • Overall, rates of overdose deaths increased by 5.5% per year between 1999 and 2015. (
  • National statistics on drug overdose deaths are based on information from death certificates. (
  • Increases in overdose deaths were seen across all age groups of whites and Hispanics, yet rising rates were most pronounced among older black men (50 or older) and older black women (45 or older). (
  • Cocaine was the largest contributor to overdose deaths among black men and women. (
  • But, the largest recent increase in overdose deaths for black and Hispanic people was due to heroin. (
  • There were too few drug overdose deaths among Asian-Americans to be able to draw meaningful conclusions about mortality rates by drug type, so this group was omitted," Shiels said. (
  • In the most recent years studied, 2012 to 2015, cocaine overdose deaths were almost as common in black men as prescription opioid deaths in white men and slightly more common in black women than deaths from heroin overdose in white women," Shiels said. (
  • Overdose Deaths Set a Record Last Year. (
  • Overdose deaths are higher than deaths from H.I.V., car crashes or gun violence at their peaks. (
  • Since 2013, the number of overdose deaths associated with fentanyls and similar drugs has grown to more than 28,000, from 3,000. (
  • The recent increases in drug overdose deaths have been so steep that they have contributed to reductions in the country's life expectancy over the last three years, a pattern unprecedented since World War II. (
  • A new study shoots down the notion that medical marijuana laws can prevent opioid overdose deaths, challenging a favorite talking point of legal pot advocates. (
  • Still, states ravaged by painkiller overdose deaths began to rethink marijuana, leading several to legalize pot for medical use. (
  • What's more, prescription pills once were involved in the largest share of overdose deaths, but that changed as heroin and then fentanyl surged. (
  • She co-authored a 2018 study on marijuana laws and overdose deaths. (
  • We weren't happy when a billboard went up saying marijuana laws reduce overdose deaths," said Brendan Saloner of Johns Hopkins Bloomberg School of Public Health. (
  • ATLANTA - When Ohio tallied what many already knew was an alarming surge in overdose deaths from an opioid known as fentanyl, the state asked the U.S. Centers for Disease Control and Prevention to investigate. (
  • This indicates a surging supply of the drug, which in some states already has propelled a significantly higher number of overdose deaths. (
  • There are also numerous evidence-based therapies that have been shown to reduce heart failure mortality, but the use of these therapies varies widely," Groeneveld said by email. (
  • But like the care given in doctors' offices, the centers' performance varies widely -- with some excelling in some areas while doing poorly in others. (
  • We can see that COVID-19's lethal impact (forecasted 80,000 deaths x 1,000 stolen days) will have resulted in 80 million stolen days. (
  • Given the Chief's underlying coronary heart disease, NIOSH investigators concluded that the physical stress of performing physical fitness training may have triggered a cardiac arrhythmia and a possible heart attack resulting in his sudden cardiac death. (
  • On June 27, 2011, a 47-year-old male career fire chief suffered sudden cardiac death shortly after physical fitness training. (
  • However, most of the studies focus on opioid-related deaths, including prescription painkillers, heroin and fentanyl. (
  • Data from the C.D.C. indicate that a state's overdose trend closely tracks the number of fentanyl-related deaths. (
  • Unpublished data for the first half of 2015 indicate an even steeper spike in fentanyl deaths, Gladden said. (
  • Green was a panelist at the summit, presenting her findings from a study of fentanyl deaths in Rhode Island. (
  • Federal officials said Thursday they hoped a new 'rescue pen' would help reduce the death toll from overdoses involving prescription painkillers. (
  • Vaccine-related deaths are considered such a rare event medical personnel/coroners receive no training to help them recognize telltale signs/symptoms, leaving survivors forever questioning the unexplained death of their child. (
  • States varied widely in vaccine coverage of children. (
  • With deaths attributed to opioid drug overdose continuing to rise, the FDA has approved a device that would allow an at-home injection of the opioid-reversal agent naloxone to prevent overdoses. (
  • A huge increase in the use of narcotic painkillers has been accompanied by a rise in addiction and overdoses, which are now responsible for more than 16,000 deaths each year. (
  • The surge in painkiller-involved overdoses has pushed drugs ahead of traffic accidents as a leading cause of death in the U.S. and prompted the U.S. Centers for Disease Control and Prevention to declare the problem an epidemic in 2011. (
  • Life expectancy at birth has fallen by nearly four months , and drug overdoses are the leading cause of death for adults under 55. (
  • Opioid prescriptions have been falling, even as the death rates from overdoses are rising. (
  • At least 28,000 people died of opioid overdoses in 2014, the highest number of deaths in U.S. history. (
  • Some cars, minivans, SUVs, and pickup trucks have much higher driver death rates than others. (
  • As high as death rates are in some models, the average rate for all vehicles is going down over time. (
  • The average driver death rate in 1989-93 models during 1990-94 was 110 per million registered vehicle years (see Status Report special issue: death rates by vehicle make, series, Oct. 14, 1995). (
  • When the Institute later computed the rates in 1999-2002 models, the average was 87 per million (see Status Report special issue: driver death rates , March 19, 2005), and now it's down to 79. (
  • The Institute computes death rates for drivers only, not passengers, because varying numbers of passengers in crashes of one vehicle versus another would affect the rates. (
  • Characteristics that influence vehicles' death rates include type and body style (2-door car, 4-door SUV, etc. (
  • None of the 15 vehicles with the lowest driver death rates is a small model. (
  • In contrast, 11 of the 16 vehicles with the highest death rates are mini or small models, and none is large or very large. (
  • This group is mostly Ford Excursions, which have a driver death rate of 115 per million - higher than the death rates in large 4-wheel-drive SUVs and higher than in all but 4 of the midsize and small counterparts. (
  • Vehicle size and weight are strongly related, so it's not surprising that driver death rates generally are higher in lighter vehicles. (
  • Pound for pound across vehicle types, cars almost always have lower death rates than pickups or SUVs. (
  • But the death rates in some models were two or even three times as high, while the rates in other vehicles were much lower. (
  • Large cars and minivans dominate among vehicle models with very low death rates. (
  • The models with the highest rates are mostly small cars and small and midsize SUVs, many of which also have high rates of death in single-vehicle rollover crashes. (
  • Many of these general patterns of death rates have been consistent since the Institute began computing the rates by vehicle make and model in the late 1980s," says Institute chief operating officer Adrian Lund (see Status Report special issue: occupant death rates, Nov. 25, 1989). (
  • Important characteristics of vehicles that influence their driver death rates are type, body style, size, and weight. (
  • This was higher than for either small or mini sports cars, so this type of vehicle was an exception to the general rule that bigger means lower death rates. (
  • Because vehicle size and weight are so closely related, it shouldn't be surprising that their effects on driver death rates are similar. (
  • This generally is because the SUVs and pickups have much higher rates of death in single-vehicle rollover crashes," Lund explains. (
  • In some weight groups, the death rates in cars were dramatically lower. (
  • Reuters Health) - Heart disease death rates vary substantially at Veterans Affairs hospitals nationwide, and a new study suggests that this holds true not just for hospitalized patients but also for outpatients. (
  • Previous research has long documented differences in death rates at hospitals across the U.S., not just at VA facilities, often focusing on deaths among hospitalized patients or within a month after discharge. (
  • At the various locations, annual death rates for heart disease ranged from a low of 5.5 percent to a high of 9.4 percent, while mortality rates for congestive heart failure ranged from 11.1 percent to 18.9 percent, researchers calculated. (
  • And some differences in patient populations that weren't possible to measure in the study- like disease severity, frailty, dementia or socioeconomic status - might have influenced death rates, he said. (
  • While some hospitals excelled at keeping patients alive, more than half of institutions around the Bay Area had worse-than-average death rates for at least one medical procedure or patient condition in 2010 and 2011, a new state report reveals. (
  • Washington Hospital in Fremont had the dubious distinction of being among only a handful of hospitals statewide with worse-than-average death rates in several categories. (
  • Others, however, topped their peers with better-than-average death rates in two or more areas, including Alta Bates Summit Medical Center in Oakland, Eden Medical Center in Castro Valley, John Muir Medical Center in Walnut Creek, and Kaiser Permanente in Redwood City. (
  • When it comes to treatment, striking differences in death rates are revealed for such illnesses as heart failure, acute heart attacks, intestinal bleeding and strokes, depending on where a patient is treated. (
  • They adjusted the death rates to take into account such risk factors as a patient's age and other health problems, then identified which hospitals had rates significantly better or worse than state averages. (
  • In 2011, it had worse-than-average death rates for heart failure and pneumonia patients. (
  • Good Samaritan Hospital in San Jose has revised its policies for treating heart failure since 2010 and 2011, when it had worse-than-average death rates for such patients, said Dr. Arthur Douville, chief medical officer. (
  • In addition to better-than-average rankings for brain surgery and intestinal bleeding, its Walnut Creek campus had worse-than-average death rates for acute stroke patients in 2011, and its Concord campus had a similar ranking for stroke patients in 2010. (
  • Other hospitals often transfer patients with cerebral bleeding to John Muir because it can handle such cases, but that can skew death rates, said Dr. Raymond Stephens, director of John Muir's primary stroke program. (
  • The financially struggling St. Rose Hospital in Hayward had worse-than-average death rates for its acute heart attack patients in both 2010 and 2011. (
  • They also tend to emphasize the fact that death rates are "rising most rapidly among white Americans," she said. (
  • Pay-for-performance schemes - which reward hospitals financially for improving the quality of care provided to patients - only reduce patient death rates in the short term. (
  • Professor Matt Sutton, from The University of Manchester who led the previous study, said: "The earlier work found significant reductions in death rates in the short-term. (
  • Our latest research shows that in the longer-term, although death rates in the North West continued to fall, the reductions for the conditions linked to the incentives were no longer larger than the national trend. (
  • Italy, which has one of the lowest maternal mortality rates in the world, suffered five deaths in seven days between December 25 and 31. (
  • For the study, Casper's team looked at U.S. counties' rates of death from heart disease between 1973 and 2010. (
  • In contrast, counties with the greatest improvements saw death rates drop between 64 percent and 83 percent -- and they were mostly in the North. (
  • In the early 1970s, almost half of counties in the Northeast were considered to have high rates of death from heart disease, versus the rest of the country. (
  • In 2010, 38 percent of the region's counties had high death rates from heart disease, versus 24 percent in the 1970s. (
  • Like the Northeast, the Midwest showed a decline in counties with high heart disease death rates. (
  • The West had, by far, the lowest death rates in the 1970s, and it's still home to most of the nation's "low-rate clusters," the study found. (
  • I think the geographic shift in death rates is also reflecting a shift from coronary heart disease to heart failure," Barr said. (
  • Preliminary C.D.C. data show death rates leveling off nationally in the early months of this year, though there is still a lot of local variation. (
  • The previous work linked medical marijuana laws to slower than expected increases in state prescription opioid death rates from 1999 to 2010. (
  • With the religious ban on alcohol consumption, Muslim countries have low rates of death from alcohol consumption. (
  • The data also show that the increased deaths correspond strongly with the use of synthetic opioids known as fentanyls. (
  • When the new researchers included data through 2017, they found the reverse: States passing medical marijuana laws saw a 23% higher than expected rate of deaths involving prescription opioids. (
  • The state of Minnesota on Tuesday launched a civil rights investigation of the Minneapolis Police Department in hopes of forcing widespread changes following the death of George Floyd, a black man who died after a white officer pressed his knee into Floyd's neck for minutes, even after he stopped moving. (
  • The way a Minneapolis police officer restrained George Floyd before he died - placing his knee on Floyd's neck while the man lay on his stomach - is widely discredited by law enforcement experts because it can cause suffocation. (
  • The deaths of Jeyaraj and Beniks happened two weeks after the death of African American man George Floyd in Minneapolis , which reignited the Black Lives Matter movement that has swept across the world. (
  • The average driver death rate in 1999-2002 passenger vehicle models during 2000-03 was 87 per million registered vehicle years. (
  • Tramadol is illegal in Egypt and it is widely used as a recreational drug, supplanting heroin and cannabis. (
  • And the death toll will likely keep growing, said CDC investigators Matt Gladden and John Halpin at the fifth annual Rx Drug Abuse and Heroin Summit here. (
  • Widely seen bystander video showing Floyd's death has sparked sometimes violent protests around the world. (
  • Several experts said they suspect positional asphyxia played a role in Floyd's death, but the medical examiner has not yet said how Floyd died. (
  • The death toll for children in the 2017-2018 season was a record-breaking 180, that number surpassed the previous high of 171 for a nonpandemic influenza season, officials said at the briefing. (
  • If mask-wearing requirements are eased, the model predicts total U.S. deaths from the pandemic could rise to 477,000. (
  • Called the Great Mortality as it caused its devastation, this second great pandemic of Bubonic Plague became known as the Black Death in the late 17th Century. (
  • This calculates out to 4 percent of the world's deaths. (
  • Researchers from the University's Faculty of Medical and Human Sciences and Manchester Business School, along with the University of Warwick and University of Cambridge, examined deaths occurring within 30 days of admission to hospital, comparing the 24 hospitals in the North West with 137 in the rest of England. (
  • The Trump administration aims to boost competition among hospitals and cut costs by letting consumers see how widely prices can vary for the same medical or surgical procedure. (
  • Overall, foodborne diseases appear to cause more illnesses but fewer deaths than previously estimated. (
  • We evaluated the number of deaths attributable to care facilities around the world ( 6 - 13 ), and in some plac- carbapenem-resistant Enterobacteriaceae by using studies es, CRE have become endemic ( 14 - 18 ). (
  • About half of the deaths in 2001-04 model Excursions during 2002-05 occurred in rollover crashes. (
  • We can say with absolute certainty that deaths from car crashes will result in vastly more stolen days. (
  • This range from best to worst has been the pattern since we began comparing deaths by make and model in the late 1980s," says Anne McCartt, Institute senior vice president for research. (
  • In the late 1980s the overall driver death rate was higher than 100. (
  • The lowest death rate among more than 200 vehicles is the Astro minivan's 7 per million registered vehicle years. (
  • Among all types and sizes of cars, the smallest 4-door models have the highest driver death rate at 148 per million registered vehicle years. (
  • For example, the driver death rate is higher in midsize sports cars (115 per million) than in mini (107) or small (71) ones. (
  • Excursions so dominate the group of very large 4-wheel-drive SUVs that they push up this group's average death rate to 76 per million compared with 47 in large counterpart vehicles and 59 in midsize ones. (
  • The model with the highest death rate of all - the two-door, two-wheel-drive Chevrolet Blazer with 308 driver deaths per million registered years - also had the highest rollover death rate (251 per million). (
  • Among cars, for example, the smallest two-door models had the highest death rate at 190 per million vehicle years. (
  • Midsize sports cars also had a high rate at 133 driver deaths per million vehicle years. (
  • The vehicle group with the lowest driver death rate was large luxury cars with 37 deaths per million vehicle years. (
  • The next lowest rate was in large minivans and station wagons with 42 deaths per million. (
  • O'Connor Hospital in San Jose had a 7.1 percent death rate for pneumonia patients in 2011, compared to a state average of 4.1 percent. (
  • The proportion of childbearing-age women varies more widely between nations, making the crude birth rate a poor choice for international comparisons. (
  • Moderate cull/death rate. (
  • The good news is that the death rate from heart disease and stroke in the United States declined 50 percent over the last 35 years, according to a new study in the Journal of the American Medical Association. (
  • Deaths involving fentanyls increased more than 45 percent in 2017 alone. (
  • Despite the sharp recent increases in drug-related deaths, some early signs suggest that 2017 could be the peak of the overdose epidemic. (
  • Under the model's best-case scenario-in which all Americans adhere to mask guidelines-the U.S. death toll is predicted to rise to 314,000 by the beginning of February. (
  • These patients with multiple chronic health problems have a high risk of serious complications and death. (
  • The rescue pen is part of a widespread campaign by public health officials, healthcare professionals and the pharmaceutical industry to find ways to promote the safe use of the drugs and reduce deaths. (
  • But new research funded by the National Institute for Health Research Health Services and Delivery Research (NIHR HS&DR) Programme published in the New England Journal of Medicine today demonstrates that while the quality of care continued to increase over the following two years, there was no further reduction in patient deaths in the region covered by the programme over that observed in the rest of England. (
  • The widely publicized study was retracted by a major health journal. (
  • We have had 8,561 deaths from cholera since its reappearance in Haiti in 2010, while 702,892 cases have been confirmed," said Health Minister Florence Duperval. (
  • For some health conditions, such as cirrhosis of the liver, alcohol is estimated to be responsible for half of the worldwide deaths from this condition. (
  • The documents on the U.S. War in Iraq published by Wikileaks contained data on 15,000 Iraqis killed in incidents that were previously unreported in the Western media or by the Iraqi Health Ministry, and therefore not counted in compilations of reported Iraqi war deaths by (
  • During this three month period, the Health Ministry counted 1,295 Iraqis killed by the occupation forces and 516 killed in what the ministry called terrorist operations, but it agreed with hospital officials who told Youssef that these figures only captured part of the death toll. (
  • Although caffeine intoxication is relatively uncommon, raising awareness about its lethal consequences could be useful for both clinicians and pathologists to identify possible unrecognized cases and prevent related severe health conditions and deaths. (
  • Declines in smoking and uncontrolled high cholesterol have helped cut coronary heart disease deaths, Barr said. (
  • The thread that connects these two events is a tangled one, and as the death toll mounts, Madeleine must seek knowledge in odd places: behind convent walls, in secret diaries, and in the yellow stare of an aging wolf. (
  • Amid the uproar over the Aqueduct death toll, Gov. Andrew M. Cuomo of New York ordered an investigation to "ensure against needless injuries to horses and to riders. (
  • China relies on domestically produced coal for more than 70 percent of its energy needs, but the mounting death toll from accidents linked to corruption and local government coverups have embarrassed the Communist Party, even as soaring oil prices increase the country's need for less-expensive energy sources such as coal. (
  • Since that date an average of 217 deaths per year have been reported, or one every 40 hours. (
  • Daily deaths will reach over 2,000 a day in January even with many states reimposing mandates before the end of the year. (
  • According to the CDC, about 70% of hospitalizations and 90% of deaths last year occurred in those age 65 years and older. (
  • What remained unclear were the precise circumstances of her death - and why a 23-year-old woman from Olympia, Washington, would have placed her body in front of Israeli military bulldozers in the first place. (
  • A remarkable 5000-year-old skeleton suggests human dwarfism was both accepted and respected in life and death in ancient China, research by a University of Otago bio-archaeologist shows. (
  • The Chinese government said a two-month investigation into possible conflicts of interest in the coal industry found that 4,578 government officials illegally held stakes in coal mines, where corruption, mismanagement and other abuses contribute to thousands of deaths each year. (
  • According to one report, 2.5 million deaths a year are caused by alcohol. (
  • We the undersigned demand a full investigation is held on the 14 year old Linthicum boy who has been charged with STABBING to death the family's 10 week old Saint Bernard puppy in his bedroom. (
  • Deaths due to accidental and intentional injuries are higher when alcohol consumption follows this pattern. (
  • However, among participants in the British trial who were on ventilators, 29 per cent of those receiving dexamethasone died compared with 41 per cent of those receiving usual care - a 30-per-cent reduction in the relative risk of death. (
  • This effect was greatest in patients with mild and moderate traumatic brain injury (20% reduction in deaths), while no clear benefit was seen in the most severely injured patients. (
  • Advancing Quality, a programme imported from the United States, was the first of these schemes to demonstrate a significant reduction in patient deaths. (
  • Overall, about 20% of death certificates reporting an unintentional overdose are missing information about the drug that caused the death, the researchers said. (
  • Nationwide, the researchers found, those deaths fell by about 62 percent. (
  • We expect deaths to stop declining and begin increasing in the next one to two weeks," the institute's researchers told CNN . (
  • Nearly 700 years after the Black Death swept through Europe, it still haunts the world as the worst-case scenario for an epidemic. (
  • Results were even more promising for critically ill people who were not on ventilators: Those taking steroids had a 23 percent chance of death compared with a 42 percent for people taking a placebo or getting standard care. (
  • Explain to interested patients that the study found substantial variability in brain-death declaration protocols among institutions as well as deviation from established national guidelines. (
  • Numerous US national surveillance studies and media reports have highlighted an alarming rise in drug poisoning deaths in recent years," said Meredith Shiels, a co-author of the study and an investigator at the National Cancer Institute. (
  • A widely publicized study suggesting that the first gene-edited babies could have shorter life spans has been retracted due to crucial errors in the analysis. (
  • The study, which was originally published June 3 in the journal Nature Medicine, showed that a genetic mutation that protects against HIV infection was linked with an increased risk of death before age 76, Live Science previously reported . (
  • But counties varied widely, the study found. (
  • However, controversy re- ies,2retrospectivecohortstudies,and1prospectivecohort mains concerning the number of deaths among persons in- study. (
  • In June, a large study in the United Kingdom suggested that the steroid dexamethasone could help reduce the risk of death for critically ill COVID-19 patients. (
  • What that shows is that the Black Death, or plague, was deadly for reasons beyond its DNA, study authors said. (
  • The drug, which has been used to treat other illnesses for decades, burst into the public consciousness in June, when a British clinical trial found it cut the risk of death by about a third for COVID-19 patients on mechanical ventilators. (
  • In this article, we report new estimates of illnesses, hospitalizations, and deaths due to foodborne diseases in the United States. (
  • These 15,000 deaths are only the tip of an iceberg of hundreds of thousands of unreported Iraqi deaths that have already been detected by more serious and scientific epidemiological studies, but the U.S. and British governments have successfully suppressed these studies by confusing the media and the public about their methods and accuracy. (
  • Our findings suggest that diabetes remains a risk factor for cancer and cancer-related death, and metformin therapy, compared to other diabetes medications , may have an important role in [managing] diabetes-associated cancer," Gong said. (
  • They said the findings may call into question the accuracy of brain-death determinations across institutions. (
  • We believe that if our findings are widely implemented they will boost the chances of people surviving head injuries in both high income and low income countries around the world. (
  • It found that administration of TXA within three hours of injury reduced the number of deaths. (
  • A 2012 Times investigation of nearly 4,000 deaths involving prescription drugs in Southern California found that most victims overdosed at home, often with family members or friends nearby. (
  • Yet that recommendation is widely ignored, The Times found. (
  • Months after the death of her first-born son, who was away at college in Arizona, Williams found comfort in his Facebook page. (
  • Scientists have cracked the genetic code of the Black Death, one of history's worst plagues, and found that its modern-day bacterial descendants haven't changed much over 600 years. (
  • Genetic differences between different strains of the same pathogenic bacterial species appear to result in widely varying immune system responses, according to new research published in PLOS Pathogens. (
  • Regular outpatient care can help improve patients' quality of life and minimize their risk of hospitalization or death. (
  • In both cases, patients can experience permanent disability or death. (
  • How many of the patients who died had been placed on antibiotics before presentation or death? (
  • We know, definitively, that age is one of two primary risk factors for COVID-19 deaths. (
  • Aromatario, M. Caffeine-Related Deaths: Manner of Deaths and Categories at Risk. (
  • Cappelletti S, Piacentino D, Fineschi V, Frati P, Cipolloni L, Aromatario M. Caffeine-Related Deaths: Manner of Deaths and Categories at Risk. (
  • In counties with the smallest improvements, heart disease deaths fell by anywhere from 9 percent to 50 percent. (
  • The Israeli government, which rarely acknowledges the deaths of Palestinian civilians killed during its military operations, went into damage-control mode. (
  • Shortly after his death, the Nashville Trades and Labor Council passed a resolution in his honor. (
  • DES MOINES, Iowa (AP) - School districts that plan to reopen classrooms in the fall are wrestling with whether to require teachers and students to wear face masks - an issue that has divided urban and rural schools and yielded widely varying guidance. (
  • In America and Europe, 30 percent or more of deaths of males 15-29 years of age were due to alcohol. (
  • Her family was told she may face the death penalty, or 25 years in jail. (
  • It bears out the experience of epidemiologists working in war-zones around the world that "passive reporting" of war deaths generally only captures between 5% and 20% of the total number of actual deaths. (