Irradiation of the whole body with ionizing or non-ionizing radiation. It is applicable to humans or animals but not to microorganisms.
A hollow part of the alveolar process of the MAXILLA or MANDIBLE where each tooth fits and is attached via the periodontal ligament.
Experimentally produced harmful effects of ionizing or non-ionizing RADIATION in CHORDATA animals.
Drugs used to protect against ionizing radiation. They are usually of interest for use in radiation therapy but have been considered for other, e.g. military, purposes.
The surgical removal of a tooth. (Dorland, 28th ed)
The effects of ionizing and nonionizing radiation upon living organisms, organs and tissues, and their constituents, and upon physiologic processes. It includes the effect of irradiation on food, drugs, and chemicals.
Penetrating, high-energy electromagnetic radiation emitted from atomic nuclei during NUCLEAR DECAY. The range of wavelengths of emitted radiation is between 0.1 - 100 pm which overlaps the shorter, more energetic hard X-RAYS wavelengths. The distinction between gamma rays and X-rays is based on their radiation source.
The transference of BONE MARROW from one human or animal to another for a variety of purposes including HEMATOPOIETIC STEM CELL TRANSPLANTATION or MESENCHYMAL STEM CELL TRANSPLANTATION.
Preparative treatment of transplant recipient with various conditioning regimens including radiation, immune sera, chemotherapy, and/or immunosuppressive agents, prior to transplantation. Transplantation conditioning is very common before bone marrow transplantation.
The relationship between the dose of administered radiation and the response of the organism or tissue to the radiation.
The creation of a visual display of the inside of the entire body of a human or animal for the purposes of diagnostic evaluation. This is most commonly achieved by using MAGNETIC RESONANCE IMAGING; or POSITRON EMISSION TOMOGRAPHY.
Transplantation between individuals of the same species. Usually refers to genetically disparate individuals in contradistinction to isogeneic transplantation for genetically identical individuals.
The clinical entity characterized by anorexia, diarrhea, loss of hair, leukopenia, thrombocytopenia, growth retardation, and eventual death brought about by the GRAFT VS HOST REACTION.
Transfer of HEMATOPOIETIC STEM CELLS from BONE MARROW or BLOOD between individuals within the same species (TRANSPLANTATION, HOMOLOGOUS) or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). Hematopoietic stem cell transplantation has been used as an alternative to BONE MARROW TRANSPLANTATION in the treatment of a variety of neoplasms.
The amount of radiation energy that is deposited in a unit mass of material, such as tissues of plants or animal. In RADIOTHERAPY, radiation dosage is expressed in gray units (Gy). In RADIOLOGIC HEALTH, the dosage is expressed by the product of absorbed dose (Gy) and quality factor (a function of linear energy transfer), and is called radiation dose equivalent in sievert units (Sv).
An alkylating agent having a selective immunosuppressive effect on BONE MARROW. It has been used in the palliative treatment of chronic myeloid leukemia (MYELOID LEUKEMIA, CHRONIC), but although symptomatic relief is provided, no permanent remission is brought about. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), busulfan is listed as a known carcinogen.
Transplantation of an individual's own tissue from one site to another site.
Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to form the active aldophosphamide. It has been used in the treatment of LYMPHOMA and LEUKEMIA. Its side effect, ALOPECIA, has been used for defleecing sheep. Cyclophosphamide may also cause sterility, birth defects, mutations, and cancer.
That portion of the electromagnetic spectrum immediately below the visible range and extending into the x-ray frequencies. The longer wavelengths (near-UV or biotic or vital rays) are necessary for the endogenous synthesis of vitamin D and are also called antirachitic rays; the shorter, ionizing wavelengths (far-UV or abiotic or extravital rays) are viricidal, bactericidal, mutagenic, and carcinogenic and are used as disinfectants.
Harmful effects of non-experimental exposure to ionizing or non-ionizing radiation in VERTEBRATES.
A condition caused by a brief whole body exposure to more than one sievert dose equivalent of radiation. Acute radiation syndrome is initially characterized by ANOREXIA; NAUSEA; VOMITING; but can progress to hematological, gastrointestinal, neurological, pulmonary, and other major organ dysfunction.
The treatment of a disease or condition by several different means simultaneously or sequentially. Chemoimmunotherapy, RADIOIMMUNOTHERAPY, chemoradiotherapy, cryochemotherapy, and SALVAGE THERAPY are seen most frequently, but their combinations with each other and surgery are also used.
An organism that, as a result of transplantation of donor tissue or cells, consists of two or more cell lines descended from at least two zygotes. This state may result in the induction of donor-specific TRANSPLANTATION TOLERANCE.
The survival of a graft in a host, the factors responsible for the survival and the changes occurring within the graft during growth in the host.
An organism whose body contains cell populations of different genotypes as a result of the TRANSPLANTATION of donor cells after sufficient ionizing radiation to destroy the mature recipient's cells which would otherwise reject the donor cells.
The ability of some cells or tissues to survive lethal doses of IONIZING RADIATION. Tolerance depends on the species, cell type, and physical and chemical variables, including RADIATION-PROTECTIVE AGENTS and RADIATION-SENSITIZING AGENTS.
A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)
Neoplasms located in the blood and blood-forming tissue (the bone marrow and lymphatic tissue). The commonest forms are the various types of LEUKEMIA, of LYMPHOMA, and of the progressive, life-threatening forms of the MYELODYSPLASTIC SYNDROMES.
The soft tissue filling the cavities of bones. Bone marrow exists in two types, yellow and red. Yellow marrow is found in the large cavities of large bones and consists mostly of fat cells and a few primitive blood cells. Red marrow is a hematopoietic tissue and is the site of production of erythrocytes and granular leukocytes. Bone marrow is made up of a framework of connective tissue containing branching fibers with the frame being filled with marrow cells.
Penetrating electromagnetic radiation emitted when the inner orbital electrons of an atom are excited and release radiant energy. X-ray wavelengths range from 1 pm to 10 nm. Hard X-rays are the higher energy, shorter wavelength X-rays. Soft x-rays or Grenz rays are less energetic and longer in wavelength. The short wavelength end of the X-ray spectrum overlaps the GAMMA RAYS wavelength range. The distinction between gamma rays and X-rays is based on their radiation source.
A nucleoside antibiotic isolated from Streptomyces antibioticus. It has some antineoplastic properties and has broad spectrum activity against DNA viruses in cell cultures and significant antiviral activity against infections caused by a variety of viruses such as the herpes viruses, the VACCINIA VIRUS and varicella zoster virus.
Elements of limited time intervals, contributing to particular results or situations.
The degree of antigenic similarity between the tissues of different individuals, which determines the acceptance or rejection of allografts.
Treatment of food with RADIATION.
Agents that destroy bone marrow activity. They are used to prepare patients for BONE MARROW TRANSPLANTATION or STEM CELL TRANSPLANTATION.
Measurement of the volume of gas in the lungs, including that which is trapped in poorly communicating air spaces. It is of particular use in chronic obstructive pulmonary disease and emphysema. (Segen, Dictionary of Modern Medicine, 1992)
The development and formation of various types of BLOOD CELLS. Hematopoiesis can take place in the BONE MARROW (medullary) or outside the bone marrow (HEMATOPOIESIS, EXTRAMEDULLARY).
The total amount of radiation absorbed by tissues as a result of radiotherapy.
An alkylating nitrogen mustard that is used as an antineoplastic in the form of the levo isomer - MELPHALAN, the racemic mixture - MERPHALAN, and the dextro isomer - MEDPHALAN; toxic to bone marrow, but little vesicant action; potential carcinogen.
Deliberate prevention or diminution of the host's immune response. It may be nonspecific as in the administration of immunosuppressive agents (drugs or radiation) or by lymphocyte depletion or may be specific as in desensitization or the simultaneous administration of antigen and immunosuppressive drugs.
The application of probability and statistical methods to calculate the risk of occurrence of any event, such as onset of illness, recurrent disease, hospitalization, disability, or death. It may include calculation of the anticipated money costs of such events and of the premiums necessary to provide for payment of such costs.
The return of a sign, symptom, or disease after a remission.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
Identification of the major histocompatibility antigens of transplant DONORS and potential recipients, usually by serological tests. Donor and recipient pairs should be of identical ABO blood group, and in addition should be matched as closely as possible for HISTOCOMPATIBILITY ANTIGENS in order to minimize the likelihood of allograft rejection. (King, Dictionary of Genetics, 4th ed)
Immunosuppression by reduction of circulating lymphocytes or by T-cell depletion of bone marrow. The former may be accomplished in vivo by thoracic duct drainage or administration of antilymphocyte serum. The latter is performed ex vivo on bone marrow before its transplantation.
A neoplasm characterized by abnormalities of the lymphoid cell precursors leading to excessive lymphoblasts in the marrow and other organs. It is the most common cancer in children and accounts for the vast majority of all childhood leukemias.
Progenitor cells from which all blood cells derive.
Techniques for the removal of subpopulations of cells (usually residual tumor cells) from the bone marrow ex vivo before it is infused. The purging is achieved by a variety of agents including pharmacologic agents, biophysical agents (laser photoirradiation or radioisotopes) and immunologic agents. Bone marrow purging is used in both autologous and allogeneic BONE MARROW TRANSPLANTATION.
Measurement of radioactivity in the entire human body.
Any of a group of malignant tumors of lymphoid tissue that differ from HODGKIN DISEASE, being more heterogeneous with respect to malignant cell lineage, clinical course, prognosis, and therapy. The only common feature among these tumors is the absence of giant REED-STERNBERG CELLS, a characteristic of Hodgkin's disease.
Cells contained in the bone marrow including fat cells (see ADIPOCYTES); STROMAL CELLS; MEGAKARYOCYTES; and the immediate precursors of most blood cells.
Tumors, cancer or other neoplasms produced by exposure to ionizing or non-ionizing radiation.
Therapeutic act or process that initiates a response to a complete or partial remission level.
An immunological attack mounted by a graft against the host because of tissue incompatibility when immunologically competent cells are transplanted to an immunologically incompetent host; the resulting clinical picture is that of GRAFT VS HOST DISEASE.
Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging.
The number of WHITE BLOOD CELLS per unit volume in venous BLOOD. A differential leukocyte count measures the relative numbers of the different types of white cells.
A form of anemia in which the bone marrow fails to produce adequate numbers of peripheral blood elements.
Transplantation of stem cells collected from the peripheral blood. It is a less invasive alternative to direct marrow harvesting of hematopoietic stem cells. Enrichment of stem cells in peripheral blood can be achieved by inducing mobilization of stem cells from the BONE MARROW.
External or interstitial irradiation to treat lymphomas (e.g., Hodgkin's and non-Hodgkin's lymphomas) and lymph node metastases and also some autoimmune diseases, such as rheumatoid arthritis.
The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. The drugs need not be in the same dosage form.
The use of IONIZING RADIATION to treat malignant NEOPLASMS and some benign conditions.
Individuals supplying living tissue, organs, cells, blood or blood components for transfer or transplantation to histocompatible recipients.
A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.
The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)
Serum containing GAMMA-GLOBULINS which are antibodies for lymphocyte ANTIGENS. It is used both as a test for HISTOCOMPATIBILITY and therapeutically in TRANSPLANTATION.
Unstable isotopes of cobalt that decay or disintegrate emitting radiation. Co atoms with atomic weights of 54-64, except 59, are radioactive cobalt isotopes.
The number of PLATELETS per unit volume in a sample of venous BLOOD.
The occurrence in an individual of two or more cell populations of different chromosomal constitutions, derived from different individuals. This contrasts with MOSAICISM in which the different cell populations are derived from a single individual.
A class of drugs that differs from other alkylating agents used clinically in that they are monofunctional and thus unable to cross-link cellular macromolecules. Among their common properties are a requirement for metabolic activation to intermediates with antitumor efficacy and the presence in their chemical structures of N-methyl groups, that after metabolism, can covalently modify cellular DNA. The precise mechanisms by which each of these drugs acts to kill tumor cells are not completely understood. (From AMA, Drug Evaluations Annual, 1994, p2026)
Transplantation between genetically identical individuals, i.e., members of the same species with identical histocompatibility antigens, such as monozygotic twins, members of the same inbred strain, or members of a hybrid population produced by crossing certain inbred strains.
A semisynthetic derivative of PODOPHYLLOTOXIN that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitotic phase of cell division, and lead to cell death. Etoposide acts primarily in the G2 and S phases of the cell cycle.
The grafting of skin in humans or animals from one site to another to replace a lost portion of the body surface skin.
The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.
A subtype of striated muscle, attached by TENDONS to the SKELETON. Skeletal muscles are innervated and their movement can be consciously controlled. They are also called voluntary muscles.
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
Disease having a short and relatively severe course.
Form of leukemia characterized by an uncontrolled proliferation of the myeloid lineage and their precursors (MYELOID PROGENITOR CELLS) in the bone marrow and other sites.
Clonal expansion of myeloid blasts in bone marrow, blood, and other tissue. Myeloid leukemias develop from changes in cells that normally produce NEUTROPHILS; BASOPHILS; EOSINOPHILS; and MONOCYTES.
An immune response with both cellular and humoral components, directed against an allogeneic transplant, whose tissue antigens are not compatible with those of the recipient.
An encapsulated lymphatic organ through which venous blood filters.
Positively-charged atomic nuclei that have been stripped of their electrons. These particles have one or more units of electric charge and a mass exceeding that of the Helium-4 nucleus (alpha particle).
Period after successful treatment in which there is no appearance of the symptoms or effects of the disease.
INFLAMMATION of the soft tissues of the MOUTH, such as MUCOSA; PALATE; GINGIVA; and LIP.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
A continuing periodic change in displacement with respect to a fixed reference. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
The induction of prolonged survival and growth of allografts of either tumors or normal tissues which would ordinarily be rejected. It may be induced passively by introducing graft-specific antibodies from previously immunized donors, which bind to the graft's surface antigens, masking them from recognition by T-cells; or actively by prior immunization of the recipient with graft antigens which evoke specific antibodies and form antigen-antibody complexes which bind to the antigen receptor sites of the T-cells and block their cytotoxic activity.
A general term for various neoplastic diseases of the lymphoid tissue.
A pyrimidine nucleoside analog that is used mainly in the treatment of leukemia, especially acute non-lymphoblastic leukemia. Cytarabine is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA. Its actions are specific for the S phase of the cell cycle. It also has antiviral and immunosuppressant properties. (From Martindale, The Extra Pharmacopoeia, 30th ed, p472)
The number of LEUKOCYTES and ERYTHROCYTES per unit volume in a sample of venous BLOOD. A complete blood count (CBC) also includes measurement of the HEMOGLOBIN; HEMATOCRIT; and ERYTHROCYTE INDICES.

Gonadotropin-releasing hormone analogue conjugates with strong selective antitumor activity. (1/1526)

Conjugation of gonadotropin-releasing hormone (GnRH) analogues GnRH-III, MI-1544, and MI-1892 through lysyl side chains and a tetrapeptide spacer, Gly-Phe-Leu-Gly (X) to a copolymer, poly(N-vinylpyrrolidone-co-maleic acid) (P) caused increased antiproliferative activity toward MCF-7 and MDA-MB-231 breast, PC3 and LNCaP prostate, and Ishikawa endometrial cancer cell lines in culture and against tumor development by xenografts of the breast cancer cells in immunodeficient mice. MCF-7 cells treated with P-X-1544 and P-X-1892 displayed characteristic signs of apoptosis, including vacuoles in the cytoplasm, rounding up, apoptotic bodies, bleb formation, and DNA fragmentation. Conjugates, but not free peptides, inhibited cdc25 phosphatase and caused accumulation of Ishikawa and PC3 cells in the G2/M phase of the cell cycle after 24 h at lower doses and in the G1 and G2 phases after 48 h. Since P-X-peptides appear to be internalized, the increased cytotoxicity of the conjugates is attributed to protection of peptides from proteolysis, enhanced interaction of the peptides with the GnRH receptors, and/or internalization of P-X-peptide receptor complexes so that P can exert toxic effects inside, possibly by inhibiting enzymes involved in the cell cycle. The additional specificity of P-X-peptides compared with free peptides for direct antiproliferative effects on the cancer cells but not for interactions in the pituitary indicates the therapeutic potential of the conjugates.  (+info)

Hematopoietic stem cell tracking in vivo: a comparison of short-term and long-term repopulating cells. (2/1526)

We have previously demonstrated that we could separate long-term repopulating stem cells from cells that provided radioprotection (short-term repopulating cells) on the basis of size and suggested that this might be due to the quiescent nature of long-term repopulating cells. To further define the activity of these populations, we used a dye (PKH26), which incorporates into the membrane of cells and is equally distributed to daughter cells when they divide. We developed an assay, which allowed us to retrieve PKH26(+) long-term and short-term repopulating cells in the hematopoietic tissues of the recipients posttransplant. We were able to recover the labeled cells and determine their cell cycle activity, as well as their ability to reconstitute secondary lethally irradiated hosts in limiting dilution. The results of our assay suggest that long-term repopulating cells are quiescent in the bone marrow (BM) 48 hours after transplant. We were able to detect only a few labeled cells in the peripheral blood posttransplant and even though cells homed to both the spleen and BM, more long-term repopulating cells homed to the marrow and only these cells, which homed to the marrow, were capable of reconstituting lethally irradiated secondary hosts long-term.  (+info)

Mutant N-ras induces myeloproliferative disorders and apoptosis in bone marrow repopulated mice. (3/1526)

Mutations that activate the N-ras oncogene are among the most frequently detected genetic alterations in human acute myeloid leukemias (AMLs), Philadelphia chromosome-negative myeloproliferative disorders (MPDs), and myelodysplastic syndromes (MDSs). However, because N-ras has not been shown to induce these disorders in an in vivo model, the role of N-ras in the evolution of myeloid leukemia is unclear. To investigate the potential of N-ras to induce myeloid leukemia, lethally irradiated mice were reconstituted with bone marrow (BM) cells infected with a retroviral vector carrying activated N-ras. Approximately 60% of these mice developed hematopoietic disorders, including severe MPDs resembling human chronic myelogenous leukemia (CML) or AML with differentiation (French-American-British [FAB] classification M2). Other reconstituted mice succumbed to hematopoietic defects that were pathologically similar to human MDSs. The latter disorders appeared to be due to a myeloid impairment that was demonstrated by enumeration of day-12 colony-forming units-spleen (CFU-S) and by in vitro colony assays. A high level of apoptosis associated with thymic atrophy and peripheral blood (PB) lymphopenia was also evident in N-ras reconstituted mice. Our results are consistent with a model in which antiproliferative effects are a primary consequence of N-ras mutations and secondary transforming events are necessary for the development of myeloid leukemia. This is the first report of an in vivo model for N-ras induced MPD and leukemia.  (+info)

Radiation induced endothelial cell retraction in vitro: correlation with acute pulmonary edema. (4/1526)

We determined the effects of low dose radiation (<200 cGy) on the cell-cell integrity of confluent monolayers of pulmonary microvascular endothelial cells (PMEC). We observed dose- and time-dependent reversible radiation induced injuries to PMEC monolayers characterized by retraction (loss of cell-cell contact) mediated by cytoskeletal F-actin reorganization. Radiation induced reorganization of F-actin microfilament stress fibers was observed > or =30 minutes post irradiation and correlated positively with loss of cell-cell integrity. Cells of irradiated monolayers recovered to form contact inhibited monolayers > or =24 hours post irradiation; concomitantly, the depolymerized microfilaments organized to their pre-irradiated state as microfilament stress fibers arrayed parallel to the boundaries of adjacent contact-inhibited cells. Previous studies by other investigators have measured slight but significant increases in mouse lung wet weight >1 day post thoracic or whole body radiation (> or =500 cGy). Little or no data is available concerning time intervals <1 day post irradiation, possibly because of the presumption that edema is mediated, at least in part, by endothelial cell death or irreversible loss of barrier permeability functions which may only arise 1 day post irradiation. However, our in vitro data suggest that loss of endothelial barrier function may occur rapidly and at low dose levels (< or =200 cGy). Therefore, we determined radiation effects on lung wet weight and observed significant increases in wet weight (standardized per dry weight or per mouse weight) in < or =5 hours post thoracic exposure to 50 200 cGy x-radiation. We suggest that a single fraction of radiation even at low dose levels used in radiotherapy, may induce pulmonary edema by a reversible loss of endothelial cell-cell integrity and permeability barrier function.  (+info)

Health-related quality of life 1 year after allogeneic or autologous stem-cell transplantation: a prospective study. (5/1526)

PURPOSE: To evaluate health-related quality of life (HRQOL) in adults treated with high-dose chemotherapy followed by allogeneic (SCT) and autologous (ASCT) stem-cell transplantation 1 year after transplantation, using data from concurrent lymphoma patients receiving combination chemotherapy (CT) as a reference. MATERIALS AND METHODS: Forty-one leukemia patients (SCT group), 51 lymphoma patients (ASCT group), and 85 CT patients completed the European Organization for Research and Treatment of Cancer QLQ-C30 questionnaire at baseline and after 1 year. RESULTS: The SCT group (median age, 36 years) had better functioning scores and less symptomatology at baseline compared with the ASCT (median age, 41 years) and CT (median age, 37 years) groups. Statistically significant differences of 10 or more points on the 0 to 100 scales were found for 10 of 15 scales and items (P< or =.01) between the SCT and ASCT groups. Global quality of life (79 v 58, P<.0001), role function (83 v 65, P = .001), sleep disturbances (6 v 28, P<.0001), and fatigue (25 v 44, P = .0001) deviated most. The differences were 10 or more points for seven of 15 scales and items comparing the SCT and CT groups, with sleep disturbances (6 v 35, P<.0001) and pain (11 v 29, P<.01) deviating most. Differences across groups were smaller after 1 year; cognitive function was the only scale with a statistically significant difference (ASCT 80 v CT 89; P = .002). Patterns of change in HRQOL scores were different between groups during follow-up. A great improvement was found in the ASCT group (P<.01 for emotional and role function, fatigue, appetite, and constipation), whereas no significant changes were observed for the SCT group. CONCLUSION: Prospective studies with extended follow-up periods are necessary to separate a slow recovery process from more permanently reduced HRQOL after transplantation and to examine the late side effects from previous treatment.  (+info)

High-dose therapy with autologous or allogeneic transplantation as salvage therapy for small cleaved cell lymphoma of follicular center cell origin. (6/1526)

Between 1985 and 1996, 51 patients with relapsed or refractory small cleaved cell lymphoma (SCCL) received high-dose chemotherapy +/- TBI in conjunction with autologous (ABMT) (36 patients) or allogeneic transplantation (15 patients). Patients were eligible for ABMT if the bone marrow biopsy done prior to the planned transplant did not reveal microscopic involvement with SCCL. Patients receiving ABMT had a median age of 48 years, had received a median of 2.5 chemotherapy regimens prior to transplantation, and were transplanted a median of 35.5 months from diagnosis. Among patients receiving ABMT, 5 year actuarial survival was 56+/-11%. Median survival was 126+ months, and median survival from diagnosis was 191 months. Univariate and multivariate analysis identified sensitive disease as the best predictor of a favorable response. Five-year actuarial survival was 66+/-12% for patients with sensitive disease at the time of transplant as compared to 29+/-17% for patients with resistant disease, P = 0.015. Median survival in patients with sensitive disease at the time of ABMT was 126+ months. By univariate analysis, survival was significantly better for patients receiving ABMT as compared to patients receiving allogeneic transplants. Median survival following allogeneic transplantation was 5 months; 5 year actuarial survival was 15+/-13%. In a multivariate analysis, which considered autologous vs allogeneic transplantation, sensitive vs resistant disease, <3 vs > or = 3 prior treatments, and prior bone marrow involvement, allogeneic transplantation was significantly associated with poor survival. Treatment-related mortality occurred in eight of 15 patients receiving allogeneic transplantation and limited the effectiveness of this therapy. High-dose therapy in conjunction with ABMT is effective therapy for patients with SCCL whose disease is sensitive to chemotherapy and whose marrows are microscopically free of disease. Because of possible selection bias, it has not been proven that this approach increases survival in these patients. Treatment-related mortality limits the effectiveness of allogeneic transplantation in SCCL.  (+info)

Ultrasound B-mode changes in the uterus and ovaries and Doppler changes in the uterus after total body irradiation and allogeneic bone marrow transplantation in childhood. (7/1526)

Internal genitalia and uterine blood flow were assessed by ultrasound in 12 females 4.0-10.9 years after total body irradiation and allogeneic bone marrow transplantation for childhood leukaemia or lymphoma. Median age of the participants was 12.7 years (range 6.1-17.6) at bone marrow transplantation and 21.5 years (11.6-25.6) at the follow-up study. At follow-up all had entered puberty and 11/12 females had experienced the menarche. Eight females received sex steroid replacement therapy, three had spontaneous pubertal development and one woman experienced symptoms of estrogen deficiency. Median uterine and ovarian volumes were significantly reduced to -2.6 standard deviation scores (SDS) (-6.3 to -0.6), P = 0.002, and -2.6 SDS (-4.8 to -0.5), P = 0.002, respectively, compared with normal controls. Follicles were only detectable in two individuals. Uterine blood flow was impaired, as a systolic blood flow could be measured in 6/9 individuals, and a diastolic blood flow in 1/9 females. Our results indicate that the prescribed dosage of hormone replacement therapy, which was sufficient to induce bleeding and suppress other stigmata of premature menopause, was inadequate to generate normal uterine growth. In order to achieve uterine growth higher doses of hormone replacement therapy may be required. Our results confirm pelvic ultrasound as a reliable tool for investigation of internal female genitalia; however, in an infertility setting further tests are indicated.  (+info)

Antiemetic efficacy of granisetron plus dexamethasone in bone marrow transplant patients receiving chemotherapy and total body irradiation. (8/1526)

Few trials exist regarding the antiemetic efficacy of granisetron in bone marrow transplant (BMT) recipients conditioned with high-dose chemotherapy and total body irradiation (TBI). In this single-center, open-label, prospective, trial, the antiemetic efficacy and safety of granisetron plus dexamethasone were evaluated in 26 patients conditioned with cyclophosphamide-containing regimens (the majority receiving 60 mg/kg per day on 2 consecutive days), and TBI (12 Gy divided over 4 days). Daily intravenous doses of granisetron 1 mg plus dexamethasone 10 mg were given 30 min prior to chemotherapy or radiation, and continued for 24 h after the last conditioning treatment for a median of 6 days (range 3-9). Emetic control was defined by the number of emetic episodes occurring within a 24 h period, or the requirement for rescue medication for nausea or vomiting. A total of 25 patients completed 186 evaluable treatment days. Response (emetic control by treatment days) was complete in 50% of patients, major in 48%, minor in 2%, and there were no failures. Adverse effects were minor, with diarrhea (15%), headache (14%), and constipation (11%) reported most often. Based on these results, the antiemetic regimen of granisetron plus dexamethasone appears effective and well tolerated during BMT conditioning with high-dose cyclophosphamide and TBI.  (+info)

TY - JOUR. T1 - Enhanced mitogen-induced proliferation of rat splenocytes by low-dose whole-body X-irradiation.. AU - Ishii, K.. AU - Yamaoka, K.. AU - Hosoi, Y.. AU - Ono, T.. AU - Sakamoto, K.. N1 - Copyright: This record is sourced from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. PY - 1995. Y1 - 1995. N2 - To elucidate the stimulative effect on the immune system, we studied the effect of acute low-dose whole-body X-irradiation on the mitogen-induced proliferative responses of rat splenocytes and thymocytes. Concanavalin A (Con A)-induced mitogen response of rat splenocytes 4 hours after 5 cGy irradiation was significantly higher (by 80%, p , 0.02) than that in sham-irradiated controls; whereas that of rat thymocytes did not show change after irradiation of 1-10 cGy. In the rats X-irradiated with doses greater than 25 cGy, Con A-induced mitogen responses of splenocytes and thymocytes were reduced. In a way similar to the Con A-induced mitogen response of ...
Total body irradiation (TBI) damages hematopoietic cells in the bone marrow and thymus; however, the long-term effects of irradiation with aging remain unclear. In this study, we found that the impact of radiation on thymopoiesis in mice varied by sex and dose but, overall, thymopoiesis remained suppressed for ≥12 mo after a single exposure. Male and female mice showed a long-term dose-dependent reduction in thymic cKit+ lymphoid progenitors that was maintained throughout life. Damage to hematopoietic stem cells (HSCs) in the bone marrow was dose dependent, with as little as 0.5 Gy causing a significant long-term reduction. In addition, the potential for T lineage commitment was radiation sensitive with aging. Overall, the impact of irradiation on the hematopoietic lineage was more severe in females. In contrast, the rate of decline in thymic epithelial cell numbers with age was radiation-sensitive only in males, and other characteristics including Ccl25 transcription were unaffected. Taken ...
Mesenchymal stem cells (MSCs) have been shown to migrate to various tissues. There is little information on the fate and potential therapeutic efficacy of the reinfusion of MSCs following total body irradiation (TBI). We addressed this question using human MSC (hMSCs) infused to nonobese diabetic/severe combined immunodeficient (NOD/SCID) mice submitted to TBI. Further, we tested the impact of additional local irradiation (ALI) superimposed to TBI, as a model of accidental irradiation. NOD/SCID mice were transplanted with hMSCs. Group 1 was not irradiated before receiving hMSC infusion. Group 2 received only TBI at a dose of 3.5 Gy, group 3 received local irradiation to the abdomen at a dose of 4.5 Gy in addition to TBI, and group 4 received local irradiation to the leg at 26.5 Gy in addition to TBI. Fifteen days after gamma irradiation, quantitative and spatial distribution of the hMSCs were studied. Histological analysis of mouse tissues confirmed the presence of radio-induced lesions in the ...
In the Subjects, Materials, and Methods Subjects section of this paper one reads: In February 2007, an HIV-infected patient underwent stem cell transplantation (SCT) due to a relapse of AML with a graft consisting of CCR5A32/A32 donor cells. The pre-transplant conditioning regimen included 100 mg/m2 of amsacrine, 30 mg/m2 of fludarabine, 2 g/m2 of cytarabine (day -12 until -9), 60 mg/kg of cyclophosphamide (days -4 and -3), 5.5 mg/kg of rabbit antithymocyte globuline (in three doses between day -3 and -1), and a 400 cGy total body irradiation (TBI; day -5). ART was discontinued on the day of transplantation, and 13 months later the patient received a second transplant with CCR5A32/A32 stem cells from the same donor due to a second relapse of AML. The conditioning regimen consisted of 100 mg/m2 of cytarabine (day -7 until day -1), 6 mg/m2 of gemtuzumab (day -7 and day -1), and a 200 cGy TBI (day -1)... Twelve months post-transplant, the patient underwent liver biopsy and histological examination ...
RATIONALE: Giving total-body irradiation and chemotherapy, such as cyclophosphamide, before a donor stem cell transplant helps stop the patients immune system from rejecting the donors stem cells and helps stop the growth of cancer or abnormal cells. When the healthy stem cells from a donor are infused into the patient they may help the patients bone marrow make stem cells, red blood cells, white blood cells, and platelets. Sometimes the transplanted cells from a donor can make an immune response against the bodys normal cells. Giving immunosuppressive therapy before or after transplant may stop this from happening.. PURPOSE: This phase II trial is studying how well giving total-body irradiation together with cyclophosphamide works in treating patients who are undergoing donor stem cell transplant for hematologic cancer and other diseases. ...
Altmetric calculates a score based on the online attention an article receives. Each coloured thread in the circle represents a different type of online attention and the number in the centre is the Altmetric score. The score is calculated based on two main sources of online attention: social media and mainstream news media. Altmetric also tracks usage in online reference managers such as Mendeley and CiteULike, but these do not contribute to the score. Older articles will typically score higher because they have had more time to get noticed. To account for this, Altmetric has included the context data for articles of a similar age (published within 6 weeks of either side of the publication date of this article).. For a more detailed description of Altmetric, the Altmetric score, and sources used, please see Altmetrics information page.. ...
The apparent ability of rats to voluntarily select a dietary according to the needs of the body was utilized in a study to detect possible metabolic derangements subsequent to a dose of 375 rad whole-body X-irradiation. The animals were allowed free choice selections of various foodstuffs offered in separate containers and the relative amounts of food intake as well as body weights were measured daily. The majority of the rats were able to select diets adequate enough to support normal growth. Upon irradiation at the level employed, rats fed a basal pre-mixed diet lost significantly more body weight than similarly treated rats selecting their own diet. In the over-all pattern, the proportion of casein selected progressively increased whereas that of sucrose decreased subsequent to the irradiation. The selections of yeast and corn oil remained essentially the same. On the third day only, after irradiation, the intake of minerals increased to over 5 times the pre-irradiation level . The selection
In this study, we found that the same therapy administered intravenously also offers protection during exposure to whole-body irradiation. Dr. Greenberger added that intravenous administration could potentially offer wide-reaching protection to the public in the event of a terrorist attack since experts believe a significant number of the population would die within 30 days of receiving a large dose of radiation to the entire body.. In the study, mice were used to test the protective effects of manganese superoxide dismutase plasmid liposome (MnSOD-PL) gene therapy on the bone marrow during whole-body irradiation. The researchers found that in a control group of mice that received an initial 9 Gy dose of radiation there was 80 percent survival at 30 days compared to 93.3 percent survival during the same length of time for an experimental group of mice that were injected with MnSOD-PL prior to irradiation. As the level of radiation exposure was increased, survival rates in the mice injected with ...
The purpose of this study is to better understand why some women who survived cancer or a related illness later develop diabetes, problems with their cholesterol, or other problems that may lead to heart disease. Because these problems may be related to treatment with total body irradiation and a stem cell transplant, the investigators will compare the rates of obesity, cholesterol problems, and diabetes between women who were treated with total body irradiation and a stem cell transplant and women who were not.. The amount and location of fat stores in the abdomen is more important than overall weight or total body fat in the development of diabetes and cholesterol problems. In general, fat can be stored in several areas in the abdomen: around the organs (visceral fat), under the skin (subcutaneous fat), and in the liver (liver fat). People with higher amounts of fat around the organs (visceral fat), even those with a normal weight, are more likely to become diabetic or have high cholesterol. ...
The hematopoietic system declines with age, resulting in decreased hematopoietic stem cell (HSC) self-renewal capacity, myeloid skewing, and immune cell depletion. Aging of the hematopoietic system is associated with an increased incidence of myeloid malignancies and a decline in adaptive immunity. Therefore, strategies to rejuvenate the hematopoietic system have important clinical implications. In this issue of the JCI, Poulos and colleagues demonstrate that infusions of bone marrow (BM) endothelial cells (ECs) from young mice promoted HSC self-renewal and restored immune cell content in aged mice. Additionally, delivery of young BM ECs along with HSCs following total body irradiation improved HSC engraftment and enhanced survival. These results suggest an important role for BM endothelial cells (ECs) in regulating hematopoietic aging and support further research to identify the rejuvenating factors elaborated by BM ECs that restore HSC function and the immune repertoire in aged mice.. ...
The hematopoietic system declines with age, resulting in decreased hematopoietic stem cell (HSC) self-renewal capacity, myeloid skewing, and immune cell depletion. Aging of the hematopoietic system is associated with an increased incidence of myeloid malignancies and a decline in adaptive immunity. Therefore, strategies to rejuvenate the hematopoietic system have important clinical implications. In this issue of the JCI, Poulos and colleagues demonstrate that infusions of bone marrow (BM) endothelial cells (ECs) from young mice promoted HSC self-renewal and restored immune cell content in aged mice. Additionally, delivery of young BM ECs along with HSCs following total body irradiation improved HSC engraftment and enhanced survival. These results suggest an important role for BM endothelial cells (ECs) in regulating hematopoietic aging and support further research to identify the rejuvenating factors elaborated by BM ECs that restore HSC function and the immune repertoire in aged mice.. ...
Purpose: Total body irradiation (TBI) is a standard treatment modality within the multidisciplinary approach for allogeneous stem cell or bone marrow transplantation. However, surviving patients are...
Poulos and colleagues demonstrate a decline in BM EC numbers, increased BM vascular leakiness, and elevated intracellular ROS levels in ECs from aged (24-month-old) C57BL/6 mice compared with those from young (3-month-old) mice. Furthermore, aged BM ECs displayed decreased proliferative and angiogenic potential and decreased expression of paracrine factors, including stem cell factor, CXCL12, and Jagged1, which are integral to the HSC-supportive function of BM ECs (6-9). Utilizing an ex vivo model to test the hematopoietic-instructive function of BM ECs, Poulos et al. showed that coculture of young BM progenitor cells with aged BM ECs caused a decline in the HSC-repopulating capacity, while coculture of aged BM progenitor cells with young ECs rescued the HSC-repopulating capacity, albeit incompletely.. In a series of in vivo experiments, Poulos and colleagues demonstrated that serial infusions of aged BM ECs failed to rescue HSC content in young mice following high-dose total body irradiation, ...
The patient reported in this study (the London patient), underwent one stem-cell transplantation, a reduced-intensity chemotherapy drug regimen, without whole body irradiation. In 2019, it was reported that their HIV was in remission, and this study provides follow-up viral load blood test results at 30-months and a modelling analysis to predict the chances of viral re-emergence.. Ultrasensitive viral load sampling from the London patients cerebrospinal fluid, intestinal tissue, or lymphoid tissue was taken at 29 months after interruption of ART and viral load sampling of their blood at 30 months. At 29 months, CD4 cell count (indicators of immune system health and stem cell transplantation success) was measured, and the extent to which the patients immune cells have been replaced by those derived from the transplant.. Results showed no active viral infection was detected in samples of the patients blood at 30 months, or in their cerebrospinal fluid, semen, intestinal tissue, and lymphoid ...
Animals and hematopoietic cell transplantation. BALB/c mice (H-2d, Thy1.2) and C57BL/6 mice (H-2b, Thy1.2) were purchased from Charles River at the age of 8-16 weeks. Transgenic mice C57BL/6.L2G85 CD90.1+ expressing luciferase (luc+) were generated by backcrossing the luc+ FVB/N-L2G85 founder line (14) with the C57BL/6 mice for more than 12 generations. Additional transgenic luc+ mice C57BL/6.L2G85 CD45.1+ mice were bred in our colony. BALB/c mice were conditioned with a total body irradiation dose of 8 Gy and i.v. injected with 5 × 106 C57BL/6 WT sex- and age-matched bone marrow cells within 2 hours after irradiation. C57BL/6.L2G85 CD90.1+ or CD45.1+ magnetic bead- separated (Invitrogen) T cells (CD4/CD8 enrichment, approximately 80% purity) were coinjected to induce GVHD. BLI. BLI was performed as previously described (13) using an IVIS Spectrum CCD imaging system (Caliper Xenogen). Mice were anesthetized with an intraperitoneally injected mixture of ketamine (50 μg/g body weight, BW) and ...
Strengthen your whole body with this AMRAP-style total-body kettlebell workout from kettlebell-certified trainer Ava Fagin of Body Space Fitness in NYC.
TY - JOUR. T1 - Allogeneic hematopoietic cell transplantation after fludarabine and 2 Gy total body irradiation for relapsed and refractory mantle cell lymphoma. AU - Maris, Michael B.. AU - Sandmaier, Brenda M.. AU - Storer, Barry E.. AU - Chauncey, Thomas. AU - Stuart, Monic Jain. AU - Maziarz, Richard T.. AU - Agura, Edward. AU - Langston, Amelia A.. AU - Pulsipher, Michael. AU - Storb, Rainer. AU - Maloney, David G.. PY - 2004/12/1. Y1 - 2004/12/1. N2 - We carried out HLA-matched related (n = 16) and unrelated (n = 17) hematopoietic cell transplantation (HCT) in 33 patients with relapsed and refractory mantle cell lymphoma after nonmyeloablative conditioning with fludarabine and 2 Gy total body irradiation. Postgrafting immunosuppression consisted of cyclosporine and mycophenolate mofetil. Fourteen patients had failed high-dose autologous HCT. Of the 33 patients studied, 31 had stable engraftment, whereas 2 patients experienced nonfatal graft rejections. The incidences of acute grades II, ...
A clear and exact quantitative relationship between dose of total body irradiation and mortality in humans is still not known because of lack of human data that would enable us to determine LD50 for humans in total body irradiation. Analysis of human data has been primarily from radiation accidents, radiotherapy and the atomic bomb victims. The author published the general mathematical equations of LD50 constructed on the basis of data presented by Cerveny, MacVittie and Young, employing the probacent formula model. In this study, the author compared the equations of tolerance of total body irradiation and decay of isotopes, uranium and thorium. Differences and similarity in these equations of the two groups are presented. The significance of similarity is specially described.
Obesity is a form of chronic inflammation, termed meta-inflammation, resulting in the development of many chronic diseases such as diabetes and cancer. In this study, we assessed the impact of obesity on recipient graft-versus-host disease (GVHD) outcome post allogeneic HSCT using mouse models. In a model of sclerodermatous chronic GVHD, lean or diet-induced obese (DIO) BALB/c mice received 800 cGy total body irradiation (TBI), bone marrow cells, and splenocytes from H2-identical but minor MHC-mismatched B10.D2 mice. To mimic major MHC mismatch transplant which results in acute GVHD impacting gut, skin and liver, lean or DIO C57BL/6 mice received 1050 cGy TBI, bone marrow cells, and different doses of purified T cells from BALB/c mice. Strikingly, after the minor mismatch HSCT, all DIO mice succumbed to gut pathology while all lean mice survived and developed sclerodermatous GVHD at week 3 post transplant. In both models, pathological assessment indicated marked gut pathology in DIO mice ...
ClinicalTrials.gov summary of Fludarabine and Total-Body Irradiation Followed By Donor Stem Cell Transplant and Cyclosporine and Mycophenolate Mofetil in Treating HIV-Positive Patients With or Without Cancer
Abstract. In a previous study, we found that total body irradiation (TBI) was essential to induce acute graft-versus-host disease (GVHD) after allogeneic H-2-i
Fludarabine, Melphalan, Total-Body Irradiation, and Donor Stem Cell Transplant in Treating Patients With Hematologic Cancer or Bone Marrow Failure Disorders…
A 45-year-old man received growth factor-mobilized blood cells from an HLA-matched unrelated male donor after conditioning with 12 Gy total body irradiation and cyclophosphamide for treatment of acute myeloid leukemia with persistent disease. He received methotrexate and tacrolimus for immunosuppression after HCT. He developed acute GVHD of the skin and gut, which resolved after treatment with steroid cream and oral beclomethasone and budesonide. Because malignant cells persisted after HCT, treatment was administered with azacytidine, and immunosuppression with tacrolimus was withdrawn by day 100, 3 months earlier than originally planned.. Malignant cells disappeared, but 7 months after HCT and 2 months after the third cycle of azacytidine, he was diagnosed with severe chronic GVHD (NIH global score). Affected sites included the skin (erythematous rash involving ,50% body surface area [BSA]), mouth (ulcers and lichenoid features), fasciae (wrist tightness and leg edema), liver (alanine ...
Host preconditioning with lymphodepletion augments the antitumor activity of infused IFNγ+CD8+ T cells (Tc0) in mice and in humans with melanoma. Yet, the extent to which lymphodepletion affects the fate of antitumor IL17A+CD8+ T (Tc17) cells-an emerging subset showing great promise in ACT murine models-remains unknown. To address this, we polarized pmel-1 CD8+ T cells to secrete IL17A or IFNγ and infused them into melanoma-bearing mice that were either (i) not lymphodepleted (0 Gy TBI) or lymphodepleted with (ii) a nonmyeloablative (5 Gy TBI) or (iii) myeloablative (9 Gy TBI requiring HSC) preparative regimen. We found that Tc17 cells regressed melanoma in myeloablated mice to a greater extent than in lymphoreplete or nonmyeloablated mice (Fig. 1A-C). Moreover, Tc17 cells, but not Tc0 cells, mediated curative responses in myeloablated mice. Additional investigation revealed that Tc17 cells converted from mainly IL17A producers into IL17A+IFNγ+ double producers 2 days after transfer into ...
In some of the past transplant failures, the donor did not have a mutated CCR5, but the conditioning regimen seemed to have significantly reduced the reservoirs of cells in the recipient that have latent HIV infections, invisible to the immune system. Brown, who required two transplants to cure his leukemia, had intensive chemical treatment and, on top of that, received whole body irradiation. The London patient, in contrast, had a milder regimen that targeted his lymphoma.. This case tells us that there is no magic conditioning regimen, Lewin says. Brown and the London patient also suffered from graft-versus-host disease as the transplanted immune systems attacked other recipient tissues as foreign. That might have had the ironic benefit of further reducing HIV reservoirs, Lewin says.. To learn more about the factors that favor a cure, amfAR, the Foundation for AIDS Research, a New York City-based foundation, in 2014 began to fund a consortium of international researchers who do transplants ...
Three spontaneous tumors of the C3H mouse have been used in a comparison of their transplantability and radiation response (local control) in syngeneic C3Hf/Sed mice and in allogeneic athymic NCr/Sed-nu/nu nude mice. The tumors were: MCaIV, a moderately well-differentiated mammary carcinoma; FSaII, a poorly differentiated fibrosarcoma; and SCCVII, a moderately well differentiated squamous cell carcinoma. The tumors were studied as fourth to seventh generation transplants. Assays to determine the number of tumor cells that, on the average, transplant the tumor to half of the recipients or transplant sites (TD50) demonstrated that these 3 tumors transplanted into the s.c. tissue of the NCr/Sed-nu/nu as readily as of C3Hf/Sed mice. The TD50 for MCaIV was slightly but significantly lower in 4-week-old NCr/Sed-nu/nu mice which had received 6 Gy whole body irradiation (WBI) 24 h before transplantation, namely, 5.8 × 104 (95% confidence limits, 4.5-7.6) versus 7.8 × 104 (6.0-10.0). The 6-Gy WBI did ...
The Biological damage rendered after a whole body irradiation is categorised into three: acute, delayed and genetic effects. The acute effects are expressed in short time to few days. Nausea, vomiting, diarrhoea, loss of appetite and uneasiness are initially noticed and depending on the radiation dose, the severity of symptoms may increase. The radiation dose yielding 50 per cen lethality (LD50) in the exposed human population, is considered at about 3.0 - 3.5 Gray (Gy) and people engaged in rescue operations are often allowed to receive doses limiting to 0.5 to 1.0 Gy. By two weeks time after an exposure of 3.0- 4.0 Gy the symptoms of the failure of bone marrow may start appearing distinctly and may lead to death within a month due to haemopoietic failure. Higher doses (more than 5 Gy) may lead to the failure of gastrointestinal system leading to acute diarrhoea and ultimately death within two weeks as happened in case of the exposure of the scrap dealer at Mayapuri in Delhi in 2010. Higher ...
Erradication of leukemia by high dose chemotherapy and total body irradiation (TBI) and the capacity of hemopoietic stem cells to repopulate the marrow form the basic concept of bone marrow...
We promote LIFE. What is your quality of life like right now? Everything we do is designed to add to, boost, and empower you to engage in a healthy and abundant life - physically, emotionally, and spiritually.. ...
TY - JOUR. T1 - Safety and efficacy of total body irradiation, cyclophosphamide, and cytarabine as a conditioning regimen for allogeneic hematopoietic stem cell transplantation in patients with acute lymphoblastic leukemia. AU - Mori, Takehiko. AU - Aisa, Yoshinobu. AU - Kato, Jun. AU - Yamane, Akiko. AU - Nakazato, Tomonori. AU - Shigematsu, Naoyuki. AU - Okamoto, Shinichiro. PY - 2012/4/1. Y1 - 2012/4/1. N2 - Disease relapse still greatly interferes with the success of allogeneic hematopoietic stem cell transplantation (HSCT) for acute lymphoblastic leukemia (ALL). This study retrospectively evaluated the long-term safety and efficacy of a conditioning regimen consisting of total body irradiation (TBI; 12 Gy), cyclophosphamide (CY; 60 mg kg -1, two doses), and high-dose cytarabine (Ara-C; 2 g m -2; four doses) for patients with ALL. Fifty-five patients (median age: 31-years old) were evaluated. Stem cells were from human leukocyte antigen-identical siblings in 22 patients and from alternative ...
The present studies investigated the cellular mechanisms for the detrimental effects of high dose whole body γ-irradiation on bone. In addition, radioadaptation and bone marrow transplantation were assessed as interventions to mitigate the skeletal complications of irradiation. Increased trabecular thickness and separation and reduced cancellous bone volume fraction, connectivity density, and trabecular number were detected in proximal tibia and lumbar vertebra 14 days following γ-irradiation with 6 Gy. To establish the cellular mechanism for the architectural changes, vertebrae were analyzed by histomorphometry 1, 3, and 14 days following irradiation. Marrow cell density decreased within 1 day (67% reduction, p , 0.0001), reached a minimum value after 3 days (86% reduction, p , 0.0001), and partially rebounded by 14 days (30% reduction, p = 0.0025) following irradiation. In contrast, osteoblast-lined bone perimeter was increased by 290% (1 day, p = 0.04), 1230% (3 days, p , 0.0001), and 530% ...
July 29, 2008 - People facing bone marrow transplants have a series of challenges to surmount. One of the first is the total destruction by radiation of their bone marrow in a process called total body irradiation. This preconditions the persons body to accept the new marrow as treatment for cancers of the blood and immune system. Preconditioning may one day be improved if a feasibility study by a group of Chicago-area researchers is validated in further studies. In experiments using a specialized manikin-like form that is the radiological equivalent of the human body, 98 percent of the intended structures received 99 percent of prescribed radiation dose, while normal body structures were spared from high doses. Compared to conventional total body irradiation, this new approach reduced radiation to critical body parts such as the heart and the lungs by as much as 64 percent and 30 percent respectively which is a distinct improvement, says lead researcher Bulent Aydogan, Ph.D. of the ...
Cancer treatments can cause damage to normal cells in your body, which can cause side effects. Everyone gets different side effects, and some people will have more problems than others.. The table below shows some of the side effects you may get with this treatment. You are unlikely to get all of those listed and you may also get some side effects that have not been listed.. Tell your doctor or nurse about any side effects that worry you. Follow the instructions below and those given to you by your doctor or nurse.. ...
During the early phases (phases 1 and 2), researchers assess safety, side effects, optimal dosages and risks/benefits. In the later phase (phase 3), researchers study whether the treatment works better than the current standard therapy. They also compare the safety of the new treatment with that of current treatments. Phase 3 trials include large numbers of people to make sure that the result is valid. There are also less common very early (phase 0) and later (phase 4) phases. Phase 0 trials are small trials that help researchers decide if a new agent should be tested in a phase 1 trial. Phase 4 trials look at long-term safety and effectiveness, after a new treatment has been approved and is on the market. ...
Recent studies have suggested that regeneration of non-haematopoietic cell lineages can occur through heterotypic cell fusion with haematopoietic cells of the myeloid lineage. Here we show that lymphocytes also form heterotypic-fusion hybrids with cardiomyocytes, skeletal muscle, hepatocytes and Purkinje neurons. However, through lineage fate-mapping we demonstrate that such in vivo fusion of lymphoid and myeloid blood cells does not occur to an appreciable extent in steady-state adult tissues or during normal development. Rather, fusion of blood cells with different non-haematopoietic cell types is induced by organ-specific injuries or whole-body irradiation, which has been used in previous studies to condition recipients of bone marrow transplants. Our findings demonstrate that blood cells of the lymphoid and myeloid lineages contribute to various non-haematopoietic tissues by forming rare fusion hybrids, but almost exclusively in response to injuries or inflammation.
The induction of delayed type of hypersensitivity to diphtheria toxoid in the guinea pig was not inhibited by total body irradiation up to 300 r in intensity. X
A Cancer Currents blog on a study suggesting that an intensive preparatory regimen should be used for younger patients with AML undergoing a stem cell transplant.
*Laboratory Findings Prior to the Start of the Preparative Regimen / Infusion: For questions 80 - 97, report all findings within two months prior to the start...
Cryonics, May 1985 TOTAL BODY WASHOUT # 7 -- WRAPPING UP On the weekend of March 22, we carried out the final experiment in our preliminary series of total body washouts. These experiments were designed to verify the compatibility of our synthetic perfusate with survival and recovery of dogs after four hours of perfusion at 4°C. As regular readers who have been following this work will know, we have had success in five out of six previous experiments in achieving long term recovery of animals. Five of the six previous TBWs involved four hours of recirculation at 4°C with one of these experiments terminating in the death of the animal 12 hours following the conclusion of the perfusion. That animal died as a result of intestinal and pancreatic bleeding (probably secondary to an undetected viral infection present before the experiment started). It was hoped that this final experiment would allow us to apply insights gained from the previous six in a way that would allow for even more rapid ...
Cryonics, May 1985 TOTAL BODY WASHOUT # 7 -- WRAPPING UP On the weekend of March 22, we carried out the final experiment in our preliminary series of total body washouts. These experiments were designed to verify the compatibility of our synthetic perfusate with survival and recovery of dogs after four hours of perfusion at 4°C. As regular readers who have been following this work will know, we have had success in five out of six previous experiments in achieving long term recovery of animals. Five of the six previous TBWs involved four hours of recirculation at 4°C with one of these experiments terminating in the death of the animal 12 hours following the conclusion of the perfusion. That animal died as a result of intestinal and pancreatic bleeding (probably secondary to an undetected viral infection present before the experiment started). It was hoped that this final experiment would allow us to apply insights gained from the previous six in a way that would allow for even more rapid ...
Total Body Tone Tuesday Workout: Another good workout today! (Do I say that every day?) Were getting some total body toning action, and I can tell you that Train Like A Beast workout is no joke! Its tough. The only video I can think of that is harder than that one is the EXTREME Abs Workout…
Irradiation and forex trading system 2520 - forex trading system 2520, fs forex signal 30, managed forex trading accounts, euro dollar analysis forex
Several functions have been proposed for the role of macrophage apoE synthesis in cholesterol homeostasis and its relation to atherosclerosis, including either proatherosclerotic or antiatherosclerotic functions.18-31 The present study confirms that hypercholesterolemia in apoE-deficient mice can be markedly reduced by transplantation with wild-type bone marrow, while heterozygous apoE-deficient bone marrow appeared to be nearly equally effective. We demonstrate that this reduction in cholesterol levels is accompanied by an increased recognition and uptake of (β)VLDL by parenchymal liver cells.. Following total body irradiation, aplasia of bone marrow develops within 2 to 3 days. BMT will lead to recovery of hematopoietic tissues after two distinct phases of engraftment. In the first, unsustained phase, monocytes and macrophages are derived from committed progenitors. In the second, sustained phase, these cells are derived from pluripotent stem cells in the bone marrow.44 Recently, it was ...
PubMed journal article: High-dose cytosine arabinoside and fractionated total body irradiation as a preparative regimen for the treatment of children with acute lymphoblastic leukemia and Down syndrome by allogeneic bone marrow transplantation. Download Prime PubMed App to iPhone, iPad, or Android
This is a single institution study of fludarabine and busulfan versus fludarabine, busulfan and low dose total body irradiation in patients undergoing allogeneic stem cell transplantation. A study population of 80 subjects will be enrolled from The John Theurer Cancer Center at Hackensack University Medical Center. Subjects who are eligible to receive allogeneic hematopoietic stem cell transplantation according to the eligibility criteria will be consented and enrolled.
HAIFA, Israel, Dec. 07, 2017 (GLOBE NEWSWIRE) -- Pluristem Therapeutics Inc. (NASDAQ:PSTI) (TASE:PSTI), a leading developer of placenta-based cell therapy products, announced today the company will present data from its Phase II-equivalent study of PLX-R18 cells for the treatment of acute radiation syndrome (ARS) at the American Society of Hematologys (ASH) 59th Annual Meeting to be held in Atlanta, Georgia, on December 9-12, 2017.. The results of the study will be presented during Program Session 506: Hematopoiesis and Stem Cells: Microenvironment, Cell Adhesion, and Stromal Stem Cells. The poster, Intramuscular Administration of Placenta-Derived Stromal Cells Enhances Survival of Rhesus Macaque Monkeys Exposed to Total Body Irradiation, will describe data from a recently announced Phase II-equivalent study under the U.S. Food and Drug Administration (FDA) Animal Rule. The data demonstrate improved survival and hematological recovery of NHPs exposed to different levels of radiation. This ...
An allogeneic hematopoietic stem cell transplantation (HSCT) can have profound and lasting adverse effects on a patients physical and psychological well-being. So far, only few studies have investigated the effectiveness of physical activity over the entire inpatient phase of an allogeneic HSCT. Purpose: We performed a randomized controlled study to examine the influence of a controlled moderate exercise program starting parallel to chemotherapeutic conditioning and total body irradiation on the patients physical and psychological constitution. Patients and methods: Forty-seven patients undergoing an allogeneic HSCT were randomly assigned to an exercise group (EG) or a control group (CG). While the EG took part in an endurance and activity of daily living-training twice a day, the CG received the clinics standard physiotherapy program once a day. Results: Significant differences and/or trends in favor of the EG were observed regarding the primary endpoint endurance performance (P = 0.002), muscular
allogeneic HCT to a previously unserved population of older or medically infirm patients. Use of this regimen also has contributed to improving allogeneic HCT outcomes over the past decade. Herein, we describe outcomes among 372 patients aged 60 years or older with advanced hematologic malignancies who underwent allogeneic HCT in prospective clinical trials. Between March 4, 1998, and December 24, 2008, 372 patients aged 60 to 75 years underwent allogeneic HCT for advanced hematologic malignancies after nonmyeloablative conditioning per multi institutional protocols executed at 18 centers coordinated through the Fred Hutchinson Cancer Research Center, Seattle, Washington.. The primary differences between protocols were the addition of fludarabine to 2 Gy total body irradiation, the SNX-5422 use of HLA matched related or unrelated or HLA mismatched grafts, variations in the duration and intensity of posttransplantation immunosuppressive medications, and disease specific protocols. These changes ...
Injury and recovery of intestinal function following 1000 rads whole-body X-irradiation of female ICR/JCL mice was investigated by assaying activities of three enzymes (invertase, L-leucine aminopeptidase, alkaline phosphatase). By comparing changes in these enzyme activities with the epithelial cell kinetics of total DNA synthesizing cell number and total cell number, the causal relationships between functional changes in the small intestine and the epithelial cell kinetics involved in the recovery process were studied. After cell injury from irradiation, first the number of DNA synthesizing cells, second the number of total cells, and last the enzyme activities decreased to the minimum value. During recovery, the order was the same: first the DNA synthesizing cell number, then the total cell number, and finally the enzyme activities. This injury process was induced by epithelial cell death in the crypt, and the subsequent recovery was the result of epithelial cell proliferation and ...
Purpose: Discovery of agents that protect or mitigate normal tissue from radiation injury during radiotherapy, accidents, or terrorist attacks is of importance. Specifically, bone marrow insufficiency, with possible infection due to immunosuppression, can occur after total body irradiation (TBI) or regional irradiation and is a major component of the acute radiation syndrome. The purpose of this study was to identify novel radioprotectors and mitigators of the hematopoietic system.. Experimental Design: High-throughput screening of small-molecule libraries was done using viability of a murine lymphocyte line as a readout with further validation in human lymphoblastoid cells. The selected compounds were then tested for their ability to counter TBI lethality in mice.. Results: All of two major classes of antibiotics, tetracyclines and fluoroquinolones, which share a common planar ring moiety, were radioprotective. Furthermore, tetracycline protected murine hematopoietic stem/progenitor cell ...
The goal of part II of this study was to evaluate the effects of gamma-radiation on circulating blood cells, functional characteristics of splenocytes, and cytokine expression after whole-body irradiation at varying total doses and at low- and high-dose-rates (LDR, HDR). Young adult C57BL/6 mice (n = 75) were irradiated with either 1 cGy/min or 80 cGy/min photons from a 60Co source to cumulative doses of 0.5, 1.5, and 3.0 Gy. The animals were euthanized at 4 days post-exposure for in vitro assays. Significant dose- (but not dose-rate-) dependent decreases were observed in erythrocyte and blood leukocyte counts, hemoglobin, hematocrit, lipopolysaccharide (LPS)-induced 3H-thymidine incorporation, and interleukin-2 (IL-2) secretion by activated spleen cells when compared to sham-irradiated controls (p < 0.05). Basal proliferation of leukocytes in the blood and spleen increased significantly with increasing dose (p < 0.05). Significant dose rate effects were observed only in thrombocyte counts. Plasma
Copyright 2013 by the Massachusetts General Hospital. Some sections copyright 2008-2009 by The President and Fellows of Harvard College.. ...
The high correlation in metabolic efficiency within twin pairs in response to therapeutic weight loss suggests a strong genetic contribution. Unexpected effects of a whole body irradiation on cialis prices 5mg the mortality rate of baby mice after an experimental infection with the vesicular stomatitis virus (VSV) Experimental evidence also shows that in many cases the protein achieves partial sequence specificity by indirect recognition, i.e., by recognizing structural properties of the DNA. Spatial mapping of city-wide PBDE levels using an exponential decay model. We have, therefore, reassigned the name GST omega to this new alpha-class anionic GST of human liver. In contrast, in adrenal medullary-transplanted animals, epibatidine elevated responses to acute noxious stimuli and markedly suppressed phase 2 formalin responses in a dose-related fashion. Two doses of U-74500A (4.0 mg/kg, i.v.) were administered 45 min prior to renal artery occlusion and then 15 min prior to reperfusion. Therefore, ...
RATIONALE: Giving low doses of chemotherapy, such as fludarabine and cyclophosphamide, and radiation therapy before a donor bone marrow transplant helps
Results to date of umbilical cord blood transplantation in adult and fully mature adolescent patients are inferior to what is seen in children, due to a
abstractNote = {Erythropoietin acts upon haemopoietic stem cells to initiate their differentiation into the erythroid series. This effect may be used in polycythaemic mice to estimate changes in the erythropoietin-sensitive stem-cell population following total-body irradiation (TBR). Generally, single doses of erythropoietin, less than that needed for maximum stem-cell response, are used to estimate changes in the stem-cell population. The validity of results using this test is based upon accepting several assumptions regarding erythropoietin kinetics. These are: (a) the contribution of endogenous erythropoietin is always negligible; (b) the origin of the dose-response curve to erythropoietin alters only because of changes in stem-cell numbers; (c) the proportion of stem cells responding to a given concentration of erythropoietin is independent of stem-cell numbers; (d) the slope of the dose-response curve does not alter; and (e) competition between erythropoietin and other factors for the stem ...
I entered the hospital on November 14th 2011 to begin my conditioning regiment. On this first day, I had a small procedure where a surgeon inserted a catheter called a double lumen broviac into a main vein near my heart muscle. The broviac would allow greater amounts of medication to enter my body quickly. The next nine days would be the most grueling days of my life. On November 15th I began three days of total body irradiation with radiation levels so high that if they werent split up, I would have died in about two weeks. After radiation therapy and for the next four days, I received chemotherapy. Before I knew it, it was Tuesday November 22nd which was my day of rest, and my body was allowed to stabilize. I know therapy is associated with recovery and some discomfort can be expected, but what I received was more than I could imagine. One type of medicine required me to shower every two hours because the residue that exuded from my skin could cause irreversible skin damage. During the other ...
In this study, the cell lines HeLa, 3T3-Swiss albino, CHO-Kl, and ARPE-19 were cultured and co-incubated with variable concentrations of S-phosphorylated thiols and Nacetylcysteine. Using MTT assays, the cultures were ...
Full text for this publication is not currently held within this repository. Alternative links are provided below where available. ...
Dr. Krishnashree Achuthan heads the Center for Cybersecurity Systems and Networks and Amrita Technology Business Incubator (Amrita TBI) at Amrita Vishwa Vidyapeetham. She is the Co-Director of Indo - U. S. and International Initiatives at Amrita Vishwa Vidyapeetham. She is also the Dean of PG Programs, Amrita School of Engineering, Coimbatore and a Professor at the department
Compare and save on Total Body Research Labs Colostrum using PricePlow - We check deals at dozens of stores so that you dont have to!
T cells are critical to the adaptive immune system, where the body adapts specifically to foreign invaders. The thymus is ... 1985). "Thyroid Tumors Following Thymus Irradiation". J Natl Cancer Inst. 74 (6): 1177-1184. doi:10.1093/jnci/74.6.1177. PMID ... T cells that attack the body's own proteins are eliminated in the thymus. Thymic epithelial cells express major proteins from ... Computed Body Tomography with MRI Correlation. Philadelphia: Lippincott Williams & Wilkins. pp. 311-324. ISBN 0-7817-4526-8. ...
Pasteurization, which partially cooks the juice, results in some change of the sweetness, body and flavor of the cider; ... irradiation has less noticeable effects. Impetus for Federal level regulation began with outbreaks of E. coli O157:H7 from ... ultraviolet germicidal irradiation (UVGI), or other proven methods to achieve a 5-log reduction in pathogens. Canada, however, ...
Smith, Douglas E.; Tyree, Ella B. (1954-05-01). "Influence of X-Irradiation Upon Body Weight and Food Consumption of the Rat". ... Smith, Douglas E.; Tyree, Ella B. (1955-12-31). "Influence of X-Irradiation Upon Water Consumption by the Rat". American ... Fractionated irradiation an experimental study". YMSY Surgery. 34 (5): 859-862. ISSN 0039-6060. OCLC 4927667588. ... Smith, Douglas E.; Tyree, Ella B. (1956). "Attempts to Provide the Rat with Nutrition during Post-Irradiation Anorexia". ...
Pickering, J. E. (1963). "Biological Effects of Whole-Body Proton Irradiation". Aerospace Medicine. 34: 942-3. PMID 14050682. ... of nuclear radiation in primates Problems in Shielding Biological Effects of Whole-Body Proton Irradiation Proton-Irradiation ... Prompt Pulmonary Ventilation and Oxygen Consumption Changes in Rhesus Monkeys Associated with Whole-Body Gamma-Irradiation. ... Prompt Pulmonary Ventilation and Oxygen Consumption Changes in Rhesus Monkeys Associated with Whole-Body Gamma-Irradiation ...
Houston, C. Stuart; Zaleski, Witold A. (1967). "The Shape of Vertebral Bodies and Femoral Necks in Relation to Activity". ... Houston, C. S. (1977). "Diagnostic irradiation of women during the reproductive period". Canadian Medical Association Journal. ...
Instead it is made by neutron irradiation of the isotope 13C which occurs naturally in carbon at about the 1.1% level. 14C has ... The short half-life ensures that the body-concentration of the radioisotope falls effectively to zero in a few days. 123I is ... Tritium is produced by neutron irradiation of 6Li 6Li + n → 4He + 3H Tritium has a half-life 4,500±8 days (approximately 12.32 ... When a nucleus loses a proton the atomic number decreases by 1. For example, 32S + n → 32P + p Neutron irradiation is performed ...
Mole, R. H. "Whole body irradiation-radiobiology or medicine? The British Journal of Radiology 26.305 (1953): 234-241. Fend L, ... Local irradiation of a tumor nodule may lead to immunogenic forms of tumor cell death and liberation of tumor cell-derived ... In contrast to the local effect of irradiation on the tumor cells, these cytotoxic T cells circulate through the blood stream ... and are thus able to destroy remaining tumor cells in distant parts of the body which were not irradiated. Accordingly, ...
Meltz ML, Reiter RJ, Herman TS, Kumar KS (March 1999). "Melatonin and protection from whole-body irradiation: survival studies ... a condition associated with the synucleinopathies like Parkinson's disease and dementia with Lewy bodies.[17][18][19] In Europe ... core body temperature, cortisol) to earlier (advance phase shift) or later (delay phase shift) times.. ... "Comprehensive treatment of dementia with Lewy bodies". Alzheimers Res Ther (Review). 7 (1): 45. doi:10.1186/s13195-015-0128-z ...
21-1. Smith, H. (1983). "Dose-effect relationships for early response to total body irradiation". Journal of the Society for ...
Joe W. Howland (1950). The effect of aureomycin and antibiotics on whole body irradiation. Ingram, M., Mason, W. B., WHIPPLE, G ... The Lockport incident: Accidental partial body exposure of humans to large doses of x-irradiation. Influence of Continuing ... The effects of irradiation from the atomic bomb on the Japanese. The effects of the atomic bomb irradiation on the Japanese. ... The effect of aureomycin and antibiotics on whole body irradiation. Biological effects of ionizing radiation. Radioactivity ...
Lymphodepletion can be achieved by total body irradiation.[23] Transferred cells multiplied in vivo and persisted in peripheral ... The body naturally does not launch an immune system attack on its own tissues. Immune tolerance therapies seek to reset the ... The final result should be a production of equipped T-cells that can recognize and fight the infected cancer cells in the body ... work together to defend the body against cancer by targeting abnormal antigens expressed on the surface of tumor cells. ...
This is performed using high-intensity chemotherapy and total body irradiation. As such, it has nothing to do with the ... Moraine (glacial debris) is moved by natural processes that allow for down-slope movement of materials on the glacier body. It ... Radiofrequency ablation (RFA) is a method of removing aberrant tissue from within the body via minimally invasive procedures. ... High-intensity focused ultrasound (HIFU) ablation removes tissue from within the body noninvasively. Bone marrow ablation is a ...
1959). "Supralethal whole body irradiation and isologous marrow transplantation in man". Journal of Clinical Investigation. 38 ... This tends to involve specialized cells able to facilitate specific function in the patients body (for example, transplantation ... further research found in the mid twentieth century that human cells could be used to help prevent the human body rejecting ...
Shank, B; Simpson, L (1982). "The role of total body irradiation in bone marrow transplantation for leukemia". Bull N Y Acad ... This followed the body scanner, Delta 50 one of the first devices to scan the whole body. Both the Delta 25 and 50 scanned the ... A prototype whole body scanner was installed at the Cleveland Clinic. The body scanner was installed there and was introduced ... One of the units at the Cleveland Clinic was used to construct an image of the body that today would be called a "Scout View", ...
Cohn S.H. (1952). "Effects of total body x-irradiation on blood coagulation in the rat". Blood. 7 (2): 225-34. doi:10.1182/ ... he led a group using whole-body counting to identify and measure radioactive material in the body. He later was part of a team ... Human Body Composition (2 ed.). Human Kinetics. p. 8. ISBN 978-0736046558. Human Body Composition Second Edition Page 9 The ... Cohn was a pioneer in the study of non-invasive measurement of calcium and other elements in the human body. He was one of the ...
A Technic for Cross-Calibration of X-Ray Units Utilizing Half-Value-Layer Determinations Dosimetry for a Total-Body Irradiation ... Leon Dosimetry for a Total-Body Irradiation Chamber Springer, Elliott B.; Pape, Leon; Elsner, Fred; Jacobs, Melville L. High- ...
Irradiation may allow lower-quality or contaminated foods to be rendered marketable. National and international expert bodies ... Activists have also opposed food irradiation for other reasons, for example, arguing that irradiation can be used to sterilize ... Food Irradiation Clearances Archived 26 May 2008 at the Wayback Machine Food irradiation - Position of ADA J Am Diet Assoc. ... High-Dose Irradiation: Wholesomeness of Food Irradiated With Doses Above 10 kGy. Report of a Joint FAO/IAEA/WHO Study Group. ...
... gained the power of elasticity from irradiation by cosmic rays. He has the ability to convert his entire body ... Reed's body was elastic and he could reshape any portion of his body at will. At his suggestion, they decided to use their new ... Maintaining his body's normal human shape requires a certain degree of ongoing concentration. When Reed is relaxed and ... Mister Fantastic's strength comes more from the powers of his mind than the powers of his body; indeed, he once told Spider-Man ...
Most cells in the human body have two receptors for TNF-alpha: TNFR1 and TNFR2. The binding of TNF-alpha to TNFR1 has been ... APAF-1 cells are protected from apoptosis stimuli such as irradiation. A BAX-1 knock-out mouse exhibits normal forebrain ... They can be exported in the apoptotic bodies that pinch off from the surface of the dying cell, and the fact that they are ... There is also a growing body of evidence indicating that nitric oxide is able to induce apoptosis by helping to dissipate the ...
In vivo blockade of CD47 using an antisense morpholino increases survival of mice exposed to lethal total body irradiation due ... "Blockade of CD47 increases survival of mice exposed to lethal total body irradiation". Scientific Reports. 3: 1038. Bibcode: ... The fact that human iPSCs are capable of forming teratomas not only in humans but also in some animal body, in particular mice ... This process allows the body to replace cells not suitable to new conditions with more suitable new cells. In Drosophila ...
This primary immunosuppressive therapy with total body irradiation was also used by Hamburger. In addition, he foresaw the ... Dempster and his associates demonstrated that irradiating the whole body could suppress delayed type hypersensitivity reactions ...
June 2010). "Gamma-tocotrienol protects hematopoietic stem and progenitor cells in mice after total-body irradiation". ... December 2010). "Delta-tocotrienol protects mouse and human hematopoietic progenitors from gamma-irradiation through ... which are essential for renewing the body's supply of blood cells. Based on these successful results of studies in mice, γ- ... are not well understood and simply increasing the intake of tocotrienols might not increase tocotrienol levels in the body. ...
M40403 was found effective in reducing oxidative tissue damage induced by total body irradiation. M40401 is similar in ... protects adult mice from lethal total body irradiation". Free Radical Research. 44 (5): 529-40. doi:10.3109/10715761003649578. ...
In allogeneic transplants, a combination of cyclophosphamide with total body irradiation is conventionally employed. This ... The chemotherapy or irradiation given immediately prior to a transplant is called the conditioning regimen, the purpose of ... transplantation is the only transplant procedure in which the transplanted cells must accept the body rather than the body ... "Allogeneic haemopoietic stem cell transplantation for multiple myeloma or plasma cell leukaemia using fractionated total body ...
"The effect of fenclofenac on the regeneration of lymphocytes in rats following total body irradiation". Int. J. Immunopharmacol ...
Static potential and secondary emission of bodies under electron irradiation)". Z. Tech. Phys. 11: 467-475. J. I. Goldstein; D ...
Oral mucositis is particularly profound and prolonged among HSCT recipients who receive total-body irradiation. Cancer patients ...
The pyrgeometer is considered to approximate a black body. Due to this it emits long wave radiation according to: E o u t = σ T ... Since the mean free path of IR radiation in the atmosphere is ~25 meters, this device typically measures IR flux in the nearest ... A temperature sensor to measure the body temperature of the instrument. A sun shield to minimize heating of the instrument due ... The atmosphere and the pyrgeometer (in effect its sensor surface) exchange long wave IR radiation. This results in a net ...
Taranova, NP (1975). "[Effect of whole-body x-irradiation on the composition and metabolism of rat brain lipids]". ... Parts of the body only thinly covered can also potentially be subjected to an outbreak. Life with SU can be difficult. Patients ... This technique is used to remove the blood plasma or fluid in the red blood cells and then return the cells to the body. It " ... If vast areas of the body are affected, the loss of fluid into the skin could lead to light-headedness, headache, nausea, and ...
In allogeneic transplants a combination of cyclophosphamide with total body irradiation is conventionally employed. This ... The chemotherapy or irradiation given immediately prior to a transplant is called the conditioning regimen, the purpose of ... transplantation is the only transplant procedure in which the transplanted cells must accept the body rather than the body ... "Allogenic haemopoietic stem cell transplantation for multiple myeloma or plasma cell leukaemia using fractionated total body ...
The alkali metals all have the same crystal structure (body-centred cubic)[10] and thus the only relevant factors are the ... itself produced synthetically from the neutron irradiation of natural radium-226, one of the daughters of natural uranium-238.[ ... This secondary hydrogen gas explosion produces the visible flame above the bowl of water, lake or other body of water, not the ... Due to their similar atomic radii, rubidium and caesium in the body mimic potassium and are taken up similarly. Rubidium has no ...
Radiance emitted by a surface, divided by that emitted by a black body at the same temperature as that surface.. ... Radiant energy received by a surface per unit area, or equivalently irradiance of a surface integrated over time of irradiation ... Spectral radiance emitted by a surface, divided by that of a black body at the same temperature as that surface.. ... Radiant exitance of a surface, divided by that of a black body at the same temperature as that surface.. ...
Therefore, many tracers that reach tumors in the body very easily would only reach brain tumors once there is a disruption of ... Conventional external beam "whole-brain radiotherapy treatment" (WBRT) or "whole-brain irradiation" may be suggested if there ... This means that a cancerous neoplasm has developed in another organ elsewhere in the body and that cancer cells have leaked ... In cancers elsewhere in the body, three malignant properties differentiate benign tumors from malignant forms of cancer: benign ...
Only high-energy radiation such as gamma ray or neutron can produce fully saturated body colors,[5] and the sources of these ... The term irradiation is a very broad one, which covers bombardment by subatomic particles as well as the use of the full range ... The gemstone irradiation is a process in which a gemstone is artificially irradiated in order to enhance its optical properties ... Irradiation, particularly when done in a nuclear reactor, can make gemstones slightly radioactive,[6] so they are typically set ...
1998). "Microstructure and nanohardness of hafnium diboride after ion irradiations". Journal of Nuclear Materials. 256 (2-3): ... bodies and hypersonic air-breathing vehicles such as scramjets and DARPA's HTV because the bow shock in front of a blunt body ...
PML body. • cytoskeleton. • nucleoplasm. • microtubule organizing center. • nuclear chromosome. • mitochondrial matrix. • ... "Protective role of miR-155 in breast cancer through RAD51 targeting impairs homologous recombination after irradiation". Proc ...
... as the body's natural immune system will try to reject, or destroy, the hand. These drugs cause the recipient to have a weaker ...
"Every Cell in Your Body Has the Same DNA. Except It Doesn't". The New York Times. 21 May 2018. Archived from the original on 23 ... ray treatment and the use of irradiation to induce somatic mutation has been a useful technique in the study of genetics.[12] ... In rare cases, intersex conditions can be caused by mosaicism where some cells in the body have XX and others XY chromosomes ( ... Somatic mosaicism occurs when the somatic cells of the body are of more than one genotype. In the more common mosaics, ...
Vitamins are nutrients required in small amounts for essential metabolic reactions in the body. These are broken down in ...
P. M. F. J. Costa, U.K. Gautam, Y. Bando and D. Golberg : «Effect of Electron Beam Irradiation and Heating on the Structural ... TW200904870A «Thermosetting resin composite composition, resin molded body, and method for producing the composition» (2009) ... B. Liu, Y. Bando, M. Wang, C. Zhi, X. Fang, C. Tang, M. Mitome and D. Golberg : «Electron-beam irradiation induced conductivity ... D. Golberg, Y. Bando : «In-situ TEM of filled nanotubes: heating electron irradiation electrical and mechanical probing» In- ...
The only parts of the body that Kyrle disease do not form are the palms, soles, and mucous membranes. Lesions may heal ... UV irradiation can be utilized after curetting the hyperkeratosis with a combination medication treatment of oral retinoids, ...
Total body irradiation (TBI) is a radiation therapy technique used to prepare the body to receive a bone marrow transplant. ... Stereotactic body radiation therapy (SBRT) refers to one or several stereotactic radiation treatments with the body, such as ... 3DCRT is still used extensively for many body sites but the use of IMRT is growing in more complicated body sites such as CNS, ... and following whole body irradiation for systemic malignancies.[28] Radiation-induced hypopituitarism mainly affects growth ...
The board is then placed on the skin, to puncture the skin and for the allergens to enter the body. If a hive appears, the ... Steroids can also be taken orally or through injection, by which every part of the body can be reached and treated, but a long ... Anaphylaxis occurs when IgE antibodies are involved, and areas of the body that are not in direct contact with the food become ... An allergen can enter the body by consuming a food containing the allergen, and can also be ingested by touching any surfaces ...
More recently, Cherenkov light has been used to image substances in the body.[11][12][13] These discoveries have led to intense ... Sinoff, C. L (1991). "Radical irradiation for carcinoma of the prostate". South African Medical Journal = Suid-Afrikaanse ... The sound waves generated by the supersonic body propagate at the speed of sound itself; as such, the waves travel slower than ... Cherenkov light emission imaged from the chest wall of a patient undergoing whole breast irradiation, using 6 MeV beam from a ...
The nitrile group is quite robust and, in most cases, is not readily metabolized but passes through the body unchanged[citation ... and sodium bicarbonate in dry media under microwave irradiation" (open access). Arkivoc: (ii) 41-44.. CS1 maint: multiple names ...
Like X-rays, the gamma rays emitted by the source pass through soft tissues of the body, but are blocked by bones and other ... by neutron activation during the irradiation of ytterbium in nuclear reactors, has been used as a radiation source in portable ... The high-temperature gamma allotrope (6.57 g/cm3) has a body-centered cubic crystalline structure.[6] The alpha allotrope ( ...
Formed in the first thermonuclear explosion in November 1952, by irradiation of uranium with neutrons; kept secret for several ... Formed in the first thermonuclear explosion in November 1952, by irradiation of uranium with neutrons; kept secret for several ...
The 1,1-dichloroethane is then converted to 1,1,1-trichloroethane by reaction with chlorine under ultraviolet irradiation: CH3 ... Studies on laboratory animals have shown that 1,1,1-trichloroethane is not retained in the body for long periods of time. ...
Full Body Burden: Growing Up in the Nuclear Shadow of Rocky Flats (2012) ... 1989: San Salvador, El Salvador; one fatality due to violation of safety rules at cobalt-60 irradiation facility.[83] ... 1990: Soreq, Israel; one fatality due to violation of safety rules at cobalt-60 irradiation facility.[83] ... 1991: Neswizh, Belarus; one fatality due to violation of safety rules at cobalt-60 irradiation facility.[83] ...
Most 131I production is from neutron irradiation of a natural tellurium target in a nuclear reactor. Irradiation of natural ... A pheochromocytoma tumor is seen as a dark sphere in the center of the body (it is in the left adrenal gland). The image is by ... I-131 will be eliminated from the body over the next several weeks after it is given. The majority of I-131 will be eliminated ... Iodine in food is absorbed by the body and preferentially concentrated in the thyroid where it is needed for the functioning of ...
The spectrum of the Sun's solar radiation is close to that of a black body[9][10] with a temperature of about 5,800 K.[11] The ... If we assume the solar radiation power P as a constant over time and the solar irradiation given by the inverse-square law, we ... Different bodies of the Solar System receive light of an intensity inversely proportional to the square of their distance from ... The amount of radiation intercepted by a planetary body varies inversely with the square of the distance between the star and ...
"Degradation of poly(l-lactic acid) by γ-irradiation". Polymer Degradation and Stability. 72 (2): 337-343. 2001-05-01. doi: ... This gradual degradation is desirable for a support structure, because it gradually transfers the load to the body (e.g. the ... a solution mimicking body fluid). After 30 days of submersion in DMEM+FBS, a PLLA scaffold lost about 20% of its weight.[36] ... it breaks down inside the body within 6 months to 2 years. ...
... derived stem cell therapy ameliorates ionizing irradiation fibrosis (RIF) via hepatocyte growth factor mediated TGF‐β down ... "Sustained expression of naked plasmid DNA encoding hepatocyte growth factor in mice promotes liver and overall body growth" ...
... total body irradiation). In the past, physicians commonly utilized radiation in the form of whole-brain radiation for central ... Signals in the body control the number of lymphocytes so neither too few nor too many are made. In ALL, both the normal ... These lymphoblasts build up in the bone marrow and may spread to other sites in the body, such as lymph nodes, the mediastinum ... The aim of treatment is to induce a lasting remission, defined as the absence of detectable cancer cells in the body (usually ...
nuclear body. • macromolecular complex. Biological process. • cellular response to extracellular stimulus. • signal ... as well as in response to UV irradiation.[33] Recent work has now found that in human cell lines SCFSkp2 degrades p21 towards ... also found that γ-irradiation of fibroblasts induced a p53 and p21 dependent cell cycle arrest, here p21 was found bound to ...
Nevertheless, there are circumstances such as disease, distress, stress, and so on that may prevent the body from obtaining ... Normally, individuals obtain the necessary nutrients their bodies require through normal daily diets that process the foods ...
Exposure can be from a source of radiation external to the human body or due to internal irradiation caused by the ingestion of ... to measure the localised body irradiation for specific activities. Common types of wearable dosimeters for ionizing radiation ... Dosimeters can be worn to obtain a whole body dose and there are also specialist types that can be worn on the fingers or ... These can be in the form of hand monitors, clothing frisk probes, or whole body monitors. These monitor the surface of the ...
Cyclophosphamide is a common cytotoxic drug used in this manner, and is often used in conjunction with total body irradiation. ... "Pregnancies following high-dose cyclophosphamide with or without high-dose busulfan or total-body irradiation and bone marrow ... Donald Pinkel (August 1958). "The Use of Body Surface Area as a Criterion of Drug Dosage in Cancer Chemotherapy". Cancer Res. ... The most common medications affect mainly the fast-dividing cells of the body, such as blood cells and the cells lining the ...
Total body irradiation (TBI) is a form of radiotherapy used primarily as part of the preparative regimen for haematopoietic ... Doses of total body irradiation used in bone marrow transplantation typically range from 10 to >12 Gy. For reference, an ... Total body irradiation results in infertility in most cases, with recovery of gonadal function occurring in 10−14% of females. ... Total body irradiation in the setting of bone marrow transplantation serves to destroy or suppress the recipients immune ...
This information will help you prepare for low dose total body irradiation (TBI) at Memorial Sloan Kettering (MSK). It will ... Low Dose Total Body Irradiation - Generated on June 17, 2019. ©2019 Memorial Sloan Kettering Cancer Center. ... This information will help you prepare for low dose total body irradiation (TBI) at Memorial Sloan Kettering (MSK). It will ... Your body is then naturally able to get rid of the damaged cancer cells. Radiation therapy also affects normal cells. However, ...
Metabolic Changes Induced in Mammalian Erythrocytes by Whole-Body X-Irradiation. Last updated: Sun, 15 Dec 2019 05:54:11 GMT ...
WHOLE-BODY IRRADIATION; ANIMAL CELLS; ANTIMITOTIC DRUGS; BIOLOGICAL MATERIALS; BLOOD; BLOOD CELLS; BODY FLUIDS; CONNECTIVE ... title = {Total body irradiation (TBI) of chronic lymphocytic leukemia (CLL)}. author = {Ruehl, U, and Johnson, R E}. ... ETDEWEB / Search Results / Total body irradiation (TBI) of chronic lymphocytic leukemia (CLL) ... Ruehl, U, and Johnson, R E. Total body irradiation (TBI) of chronic lymphocytic leukemia (CLL). Germany: N. p., 1975. Web. ...
... Muzaffer Keklik,1 Leylagul Kaynar,1 Afra ... Total body irradiation (TBI) combined with chemotherapy is widely used as a pretreatment regimen of bone marrow transplantation ... D.-Z. Li, P.-Y. Kong, J.-G. Sun et al., "Comparison of total body irradiation before and after chemotherapy in pretreatment for ... Y. Belkacémi, M. Ozsahin, F. Pène et al., "Cataractogenesis after total body irradiation," International Journal of Radiation ...
What is total body irradiation?. TBI is radiotherapy to the whole body. Radiotherapy is the use of high energy X-rays to kill ... Total Body Irradiation Introduction. You have been advised to have a course of radiotherapy as part of your treatment regimen ... TBI is very effective in killing diseased cells anywhere in the body. We use it because it also destroys your immune system and ... designed to give you some general information and answer some of the questions most people ask about total body irradiation ( ...
Stereotaxic Body Irradiation of Oligometastase in Sarcoma (Stereosarc) (Stereosarc). The safety and scientific validity of this ... Stereotactic irradiation is associated with an excellent tolerance with rates of grade 3 or more toxicities below 5%. ... Associations between irradiation and immunomodulatory agents appear to be synergistic and show favorable tolerance profiles. ... Ablative strategies to treat patients with oligometastases from sarcomas yield prolonged survival times and stereotactic body ...
Total Body Irradiation Treatment of the whole body with radiotherapy is sometimes used to prepare the body for a bone marrow ... Total Body Irradiation (TBI). This page has been produced to provide information about total body irradiation (TBI) and aims to ... Lung studies may show some abnormality even after a low dose of irradiation. Symptoms might never occur, but if they do, are ... Suppress the bodys immune system and reduce the chance of rejection of the transplant. ...
ETDEWEB / Search Results / Recovery of the Erythropoietin-Sensitive Stem-Cell Population following Total-Body X-Irradiation ... Byron, J. W. Recovery of the Erythropoietin-Sensitive Stem-Cell Population following Total-Body X-Irradiation. IAEA: N. p., ... Byron, J. W. Recovery of the Erythropoietin-Sensitive Stem-Cell Population following Total-Body X-Irradiation. IAEA. ... title = {Recovery of the Erythropoietin-Sensitive Stem-Cell Population following Total-Body X-Irradiation}. author = {Byron, J ...
... Manju Sharma, Troy Dos Santos, Susanta K ... A rigid body in three dimensions contains six degrees of freedom. The three-dimensional location of the rigid body, x = (x, y, ... Figure 2a shows a flowchart of total marrow irradiation process with anticipated addition to monitor real time body motion ( ... To track body segments such as boney anatomy, the rigid bodies tracked must be manually defined by an operator on captured data ...
Total body irradiation (TBI) is a standard treatment modality within the multidisciplinary approach for allogeneous stem cell ... Total-body irradiation - role and indications. Strahlenther Onkol 2006;182:222-230.PubMedCrossRefGoogle Scholar ... Long-term complications of total body irradiation in adults. Int J Radiat Oncol Biol Phys 2001;49:125-131.PubMedCrossRefGoogle ... Second cancer after total-body irradiation (TBI) in childhood. Strahlenther Onkol 2009;185(Suppl 2):13-16.PubMedGoogle Scholar ...
Donaldson, D. M., Marcus, S., Gyi, I. K., Perkins, E. H.:The influence of immunization and total body X-irradiation on ... Rodák, L., Černá, J.:Pathomorphological changes in cocks and hens after whole body irradiation with x-rays. (In Czech). Vet. ... Elimination of I131-labelled heterologous antigen from the blood of chickens after total body X-irradiation. ... The effect of irradiation was most marked with chickens injected with antigen 6 days after irradiation, resulting in an ...
Personalized dosing of cyclophosphamide in the total body irradiation-cyclophosphamide conditioning regimen: a phase II trial ... PERSONALIZED DOSING OF CYCLOPHOSPHAMIDE IN THE TOTAL BODY IRRADIATION - CYCLOPHOSPHAMIDE CONDITIONING REGIMEN: A PHASE II TRIAL ... PERSONALIZED DOSING OF CYCLOPHOSPHAMIDE IN THE TOTAL BODY IRRADIATION - CYCLOPHOSPHAMIDE CONDITIONING REGIMEN: A PHASE II TRIAL ... PERSONALIZED DOSING OF CYCLOPHOSPHAMIDE IN THE TOTAL BODY IRRADIATION - CYCLOPHOSPHAMIDE CONDITIONING REGIMEN: A PHASE II TRIAL ...
L. H. Gerig, J. Szanto, T. Bichay, and P. Genest, "A translating-bed technique for total-body irradiation," Physics in Medicine ... E. Alyea, D. Neuberg, P. Mauch et al., "Effect of total body irradiation dose escalation on outcome following T-cell-depleted ... S. L. McAfee, S. N. Powell, C. Colby, and T. R. Spitzer, "Dose-escalated total body irradiation and autologous stem cell ... S. Marnitz, A. Zich, P. Martus et al., "Long-term results of total body irradiation in adults with acute lymphoblastic leukemia ...
Ellington, F. (1947) Influence of dose fractionation on the lethal X-ray effect produced by total body irradiation in mice. ... Predictive formulas expressing relationship between dose rate and survival time in total body irradiation in mice () ... Chung, S. (2011) Predictive formulas expressing relationship between dose rate and survival time in total body irradiation in ... 1985) Effect of dose-rate on total body irradiation: Lethality and pathologic findings. Radiology and Oncology, 4, 341-351. doi ...
Total Body Irradiation + Rituximab Etoposide 60 mg/kg intravenous (IV) Daily Over 4 Hours for 1 Day + Total Body Irradiation ( ... Rituximab to the Preparative Regimen of Etoposide and Total Body Irradiation in Acute Lymphoblastic Leukemia. The safety and ... Total body irradiation (TBI) uses low level radiation to also interfere with the production of cancer cells at the DNA and RNA ... Experimental: Etoposide + Total Body Irradiation Etoposide 60 mg/kg IV Daily Over 4 Hours for 1 Day + TBI 3 Gy Daily for 4 Days ...
... ... Chemotherapy, Total-Body Irradiation, and Peripheral Stem Cell Transplantation in Treating Older Patients With Acute Myeloid ... Patients receive fludarabine IV on days -4 to -2. Patients undergo total-body irradiation on day 0 followed by allogeneic stem ... Home » Topics » Cancer Disease » Research » Total-Body Irradiation, Fludarabine, and Peripheral Stem Cell Transplantation in ...
Drug: fludarabine phosphate Radiation: total-body irradiation Drug: mycophenolate mofetil Drug: tacrolimus Procedure: ... and Mycophenolate Mofetil in Preventing Graft-Versus-Host Disease in Patients Who Have Undergone Total-Body Irradiation With or ... and mycophenolate mofetil works in preventing graft-versus-host disease in patients who have undergone total-body irradiation ( ... Sometimes the transplanted cells from a donor can also make an immune response against the bodys normal cells. Giving ...
Giving total-body irradiation (TBI) before a donor bone marrow transplant using stem cells that closely match the patients ... Total-Body Irradiation Followed By Cyclosporine and Mycophenolate Mofetil in Treating Patients With Severe Combined ... This pilot clinical trial studies total-body irradiation followed by cyclosporine and mycophenolate mofetil in treating ... Sometimes the transplanted cells from a donor can also make an immune response against the bodys normal cells. Giving ...
Drug: fludarabine phosphate Drug: melphalan Radiation: total-body irradiation Drug: tacrolimus Drug: mycophenolate mofetil Drug ... This phase II trial studies how well giving fludarabine phosphate, melphalan, and low-dose total-body irradiation (TBI) ... Fludarabine Phosphate, Melphalan, and Low-Dose Total-Body Irradiation Followed by Donor Peripheral Blood Stem Cell Transplant ... Sometimes the transplanted cell from a donor can make an immune response against the bodys normal cells. Giving tacrolimus, ...
Chemotherapy Total Body Irradiation and Post-Transplant Cyclophosphamide in Reducing Rates of Graft Versus Host Disease in ... Chemotherapy Total Body Irradiation and Post-Transplant Cyclophosphamide in Reducing Rates of Graft Versus Host Disease in ... Giving chemotherapy and total-body irradiation before a donor stem cell transplant helps stop the growth of cells in the bone ... This phase II trial studies how well chemotherapy, total body irradiation, and post-transplant cyclophosphamide work in ...
Fludarabine/busulfan versus fludarabine/total-body-irradiation (2 Gy) as conditioning prior to allogeneic stem cell ... Fludarabine-busulfan versus fludarabine-total-body-irradiation (2 Gy) as conditioning prior to allogeneic stem cell ... or fludarabine/total-body-irradiation-2Gy (FluTBI2Gy). A total of 1088 patients were included (median age 65 years). Donors ...
Total Body Irradiation With Fludarabine Conditioning Followed by Transplantation With Combined Umbilical Cord Blood Grafts. ... Total Body Irradiation With Fludarabine Conditioning Followed by Transplantation With Combined Umbilical Cord Blood Grafts ... is that the stem cell dose, measured in nucleated cells/kg body weight, is considerably. lower due to the size of the recipient ...
based on its metabolism when given in combination with total body irradiation and. hematopoietic stem cell transplantation in ... A Phase I Trial Of Total Body Irradiation, Cyclophosphamide Dose-Adjustment Based On Its Metabolism, And Hematopoietic Stem ... A Phase I Trial Of Total Body Irradiation, Cyclophosphamide Dose-Adjustment Based On Its Metabolism, And Hematopoietic Stem ... Preparative regimen: Patients undergo total body irradiation twice daily on days -6 to. -4. Patients then receive dose-adjusted ...
Sublethal Total Body Irradiation Causes Long-Term Deficits in Thymus Function by Reducing Lymphoid Progenitors. Shiyun Xiao, ... Total body irradiation (TBI) damages hematopoietic cells in the bone marrow and thymus; however, the long-term effects of ... Sublethal Total Body Irradiation Causes Long-Term Deficits in Thymus Function by Reducing Lymphoid Progenitors ... Sublethal Total Body Irradiation Causes Long-Term Deficits in Thymus Function by Reducing Lymphoid Progenitors ...
Whole-body Irradiation. Irradiation of the whole body with ionizing or non-ionizing radiation. It is applicable to humans or ... or lower hemibody irradiation (LHBI). Less common is mid-body irradiation (MBI). In the treatment of both halves of the body ... Hemibody Irradiation. Irradiation of one half or both halves of the body in the treatment of disseminated cancer or widespread ... Total-body irradiation (TBI) is a major constituent of myeloablative conditioning regimens. The standard technique consists of ...
Total Body Irradiation-Based Myeloablative Haploidentical Stem Cell Transplantation Is a Safe and Effective Alternative to ... Total Body Irradiation-Based Myeloablative Haploidentical Stem Cell Transplantation Is a Safe and Effective Alternative to ... "Total Body Irradiation-Based Myeloablative Haploidentical Stem Cell Transplantation Is a Safe and Effective Alternative to ... Total Body Irradiation-Based Myeloablative Haploidentical Stem Cell Transplantation Is a Safe and Effective Alternative to ...
... dose busulfan or total-body irradiation and bone marrow transplantation. JE Sanders, J Hawley, W Levy, T Gooley, CD Buckner, HJ ... Pregnancies following high-dose cyclophosphamide with or without high- dose busulfan or total-body irradiation and bone marrow ... Pregnancies following high-dose cyclophosphamide with or without high- dose busulfan or total-body irradiation and bone marrow ... Pregnancies following high-dose cyclophosphamide with or without high- dose busulfan or total-body irradiation and bone marrow ...
Conditioning with 8-Gy total body irradiation and fludarabine for allogeneic hematopoietic stem cell transplantation in acute ... Conditioning with 8-Gy total body irradiation and fludarabine for allogeneic hematopoietic stem cell transplantation in acute ... Conditioning with 8-Gy total body irradiation and fludarabine for allogeneic hematopoietic stem cell transplantation in acute ... Conditioning with 8-Gy total body irradiation and fludarabine for allogeneic hematopoietic stem cell transplantation in acute ...
ClinicalTrials.gov summary of Fludarabine and Total-Body Irradiation Followed By Donor Stem Cell Transplant and Cyclosporine ... Radiation: total-body irradiation. Undergo TBI. Other Name: TBI. Procedure: peripheral blood stem cell transplantation. Undergo ... Radiation : total-body irradiation. Procedure : peripheral blood stem cell transplantation. Drug : cyclosporine. Drug : ... Fludarabine and Total-Body Irradiation Followed By Donor Stem Cell Transplant and Cyclosporine and Mycophenolate Mofetil in ...
  • Total body irradiation (TBI) is a form of radiotherapy used primarily as part of the preparative regimen for haematopoietic stem cell (or bone marrow) transplantation. (wikipedia.org)
  • TBI is radiotherapy to the whole body. (cancernet.co.uk)
  • Treatment of the whole body with radiotherapy is sometimes used to prepare the body for a bone marrow transplant. (newcastle-hospitals.org.uk)
  • Although locoregional relapse is frequent after definitive radiotherapy (RT) or multimodal treatments, re-irradiation is only performed in few patients even in palliative settings like e.g. vertebral metastasis. (biomedcentral.com)
  • Aim: To retrospectively evaluate the efficacy and safety of definitive fractionated re-irradiation for local recurrence following stereotactic body radiotherapy (SBRT) for primary lung cancer. (elsevier.com)
  • With the development of highly accurate radiotherapy devices, prostate salvage re-irradiation might generate lower toxicity rates than classical salvage therapies. (biomedcentral.com)
  • Cancers of the spinal cord or other body organs can be effectively treated using a linear accelerator-based technology called stereotactic body radiotherapy (SBRT). (nyp.org)
  • Radiotherapy (RT) with ionizing irradiation is commonly used to locally attack tumors. (frontiersin.org)
  • Certain chemotherapeutic agents (CT) and ionizing irradiation (X-ray) that is applied in radiotherapy (RT), mostly in combination with further immune stimulation, may render the tumor cells immunogenic. (frontiersin.org)
  • Personalized dosing of cyclophosphamide in the total body irradiation-cyclophosphamide conditioning regimen: a phase II trial in patients with hema. (nih.gov)
  • This study investigates the efficacy and safety of personalized cyclophosphamide (CY) dosing in 50 patients receiving CY along with total body irradiation (TBI). (nih.gov)
  • Previous studies, over 20 years ago, suggested that there was an increased antileukemic effect using a higher dose of total body irradiation (TBI) in combination with cyclophosphamide (CY) (12 versus 15.75 Gy). (hindawi.com)
  • This phase II trial studies how well chemotherapy, total body irradiation, and post-transplant cyclophosphamide work in reducing rates of graft versus host disease in patients with hematologic malignancies undergoing a donor stem cell transplant. (centerwatch.com)
  • Determine a safe and reproducible method of adjusting the dose of cyclophosphamide based on its metabolism when given in combination with total body irradiation and hematopoietic stem cell transplantation in patients with hematologic malignancy. (knowcancer.com)
  • Patients will receive intensity modulated total body irradiation (TBI) at a dose of 3 Gy with standard fludarabine/ i.v. cyclophosphamide conditioni. (bioportfolio.com)
  • In a previous phase I study, it was concluded that tolerable doses of busulfan (BU), cyclophosphamide (CY) and total body irradiation (TBI) were 8 mg/kg, 60 mg/kg and 12.0 Gy, respectively, for autologous marrow transplant recipients. (nih.gov)
  • In the present study, we aimed to evaluate GVHD associated with bendamustine (BEN) conditioning in conjunction with total body irradiation (TBI) as an alternative to the standard myeloablative regimen of cyclophosphamide (CY) and TBI. (elsevier.com)
  • This phase II trial studies how well giving an umbilical cord blood transplant together with cyclophosphamide (CY), fludarabine phosphate (FLU), and total-body irradiation (TBI) works in treating patients with hematologic disease. (sparkcures.com)
  • Dose and dose rate effects of whole-body gamma-irradiation: II. (nasa.gov)
  • MPG protection against radiation sickness and weight loss and its correlation with mortality of mice after whole-body gamma-irradiation. (semanticscholar.org)
  • A method for producing a polymeric film resistant to degradation during sterilization such as gamma irradiation is presented. (google.es)
  • 7 . The method of claim 1 , wherein the radiation is chosen from gamma irradiation, x-ray irradiation, ultraviolet (UV) irradiation and electron beam irradiation and the storing is over a period of three days or more. (google.es)
  • It is not related to the practice of gamma irradiation of blood in transfusion medicine. (wikipedia.org)
  • This information will help you prepare for low dose total body irradiation (TBI) at Memorial Sloan Kettering (MSK). (mskcc.org)
  • Determine the response rate and duration of response in patients with low-risk hematologic malignancies treated with low-dose total-body irradiation (TBI) and fludarabine followed by HLA-matched allogeneic stem cell transplantation followed by a slow immunosuppression taper and donor leukocyte infusions (DLI). (bioportfolio.com)
  • This phase II trial studies how well giving fludarabine phosphate, melphalan, and low-dose total-body irradiation (TBI) followed by donor peripheral blood stem cell transplant (PBSCT) works in treating patients with hematologic malignancies. (clinicaltrials.gov)
  • Clofarabine and Low Dose Total Body Irradiation as a Preparative Regimen for Stem Cell Transplant in Leukemia. (bioportfolio.com)
  • This is a single institution study of fludarabine and busulfan versus fludarabine, busulfan and low dose total body irradiation in patients undergoing allogeneic stem cell transplantation. (aamds.org)
  • Subjects will be randomly assigned to receive one of 2 conditioning regimen: fludarabine and busulfan, or fludarabine busulfan and low dose total body irradiation (TBI). (aamds.org)
  • rATG on days -3, -2 and -1 Other Names: Fludara Busulfex Drug: Fludarabine and Busulfan + Low Dose Total Body Irradiation (LD TBI) Fludarabine 40mg/m2 and Busulfan 130mg/m2 on days -6, -5, -4 and -3 of transplant. (aamds.org)
  • Low-dose total body irradiation followed by allogeneic lymphocyte infusion may induce remission in patients with refractory hematologic malignancy. (rtrn.net)
  • on behalf of the HLA Working Group of the Japan Society for Hematopoietic Cell Transplantation 2019, ' Clinical significance of low-dose total body irradiation in HLA-mismatched reduced-intensity stem cell transplantation ', Bone Marrow Transplantation . (elsevier.com)
  • Total body irradiation (TBI) combined with chemotherapy is widely used as a pretreatment regimen of bone marrow transplantation (BMT) in hematologic disorders. (hindawi.com)
  • Recently, total marrow irradiation is being explored as a part of the hematopoietic cell transplantation (HCT) preparative regimen. (spiedigitallibrary.org)
  • To determine the progression free survival (PFS) of the preparative regimen rituximab, etoposide and total body irradiation (TBI), in patients with acute lymphoblastic leukemia (ALL) receiving allogeneic hematopoietic stem cell transplantation (SCT). (clinicaltrials.gov)
  • Preparative regimen: Patients undergo total body irradiation twice daily on days -6 to -4. (knowcancer.com)
  • Thyroid dysfunction (TD) was usually described in hematopoietic stem cell transplantation (HSCT) recipients who were given total body irradiation (TBI) in the conditioning regimen. (bioportfolio.com)
  • We enrolled 30 patients on a prospective phase II trial utilizing a total body irradiation (TBI)-based myeloablative preparative regimen (fludarabine 30 mg/m2/day × 3 days and TBI 150 cGy twice per day on day -4 to -1 [total dose 1200 cGy]) followed by infusion of unmanipulated peripheral blood stem cells from a haploidentical family donor (haplo). (unboundmedicine.com)
  • Preparative conditioning therapy consisted of cytosine arabinoside (Ara-C) and fractionated total body irradiation (F-TBI) and GVHD prophylaxis of cyclosporin A. The conditioning regimen was well tolerated, the only acute complication being mild mucositis. (unboundmedicine.com)
  • Results of Haploidentical Stem Cell Transplantation after a Conditioning Regimen without Total Body Irradiation in Elderly Patients with Advanced Myeloid and Lymphoid Malignancies. (aspergillus.org.uk)
  • Total body irradiation (TBI) is part of the preconditioning regimen for allogeneic bone marrow transplantation (alloBMT) and the procedure is associated with treatment-related toxicity and delayed immune reconstitution. (frontiersin.org)
  • Sublethal whole body irradiation, a conditioning regimen associated with donor T cell persistence, had little impact on donor T cell magnitude or disease outcome, but did increase T cell persistence. (biomedcentral.com)
  • Total body irradiation in the setting of bone marrow transplantation serves to destroy or suppress the recipient's immune system, preventing immunologic rejection of transplanted donor bone marrow or blood stem cells. (wikipedia.org)
  • Doses of total body irradiation used in bone marrow transplantation typically range from 10 to >12 Gy. (wikipedia.org)
  • Non-myeloablative bone marrow transplantation uses lower doses of total body irradiation, typically about 2 Gy, which do not destroy the host bone marrow but do suppress the host immune system sufficiently to promote donor engraftment. (wikipedia.org)
  • In addition to its use in bone marrow transplantation, total body irradiation has been explored as a treatment modality for high-risk Ewing sarcoma. (wikipedia.org)
  • With the increasing use of bone marrow transplantation (BMT) for hematologic malignancies, total body irradiation (TBI) is becoming a more commonplace procedure. (hindawi.com)
  • Total body irradiation (TBI) is a standard treatment modality within the multidisciplinary approach for allogeneous stem cell or bone marrow transplantation. (springer.com)
  • Cataracts after total body irradiation and marrow transplantation: a sparing effect of dose fractionation. (springer.com)
  • PURPOSE: Phase II trial to study the effectiveness of combining total-body irradiation with fludarabine and donor peripheral stem cell transplantation in treating patients who have hematologic cancer. (bioportfolio.com)
  • Patients undergo total-body irradiation on day 0 followed by allogeneic stem cell transplantation. (bioportfolio.com)
  • Single Dose Daily Fractionated Is Not Inferior To Twice A Day Fractionated Total Body Irradiation Prior To Allogeneic Stem Cell Transplantation For Acute Leukemia: A Useful Practice Simplification Resulting From The Sarasin Study. (bioportfolio.com)
  • Influence of total body irradiation dose rate on idiopathic pneumonia syndrome in acute leukemia patients undergoing allogeneic hematopoietic cell transplantation. (bioportfolio.com)
  • Total body irradiation for hematopoietic stem cell transplantation during early childhood is associated with the risk for diabetes mellitus. (bioportfolio.com)
  • This study was performed to determine pregnancy outcome among patients who had received high-dose chemotherapy alone or with total-body irradiation (TBI) and marrow transplantation for aplastic anemia or hematologic malignancy. (bloodjournal.org)
  • Women who had total body irradiation to prepare for blood or marrow transplantation before age 30 had a 4.5-fold increase in their risk of developing breast cancer later in life. (uab.edu)
  • Smita Bhatia, M.D. A new study examining long-term outcomes of blood or marrow transplantation (BMT) found that patients who received total body irradiation (TBI) at age 30 or younger had a 4.5-fold increase in their risk of developing breast cancer later in life compared with the general population. (uab.edu)
  • Total Body Irradiation for Hematopoietic Stem Cell Transplantation: What Can We Agree on? (stembook.org)
  • In addition, although it has been reported that allogeneic bone marrow transplantation conditioning with high-dose chemotherapy and total body irrradiation (TBI) causes irreversible depletion of colony-forming units-fibroblasts (CFU-F) and a 20% loss of BMD, 10 the specific effect of ionizing radiation on BM MSC is still not determined. (haematologica.org)
  • In an analysis from the Blood or Marrow Transplantation Survivor Study reported in the Journal of Clinical Oncology , McDonald et al found that total-body irradiation in women undergoing autologous or allogeneic blood or marrow transplantation for hematologic malignancies was associated with an increased risk of developing breast cancer. (ascopost.com)
  • On multivariate analysis, exposure to total-body irradiation was associated with increased risk of breast cancer among both allogeneic blood or marrow transplantation survivors (hazard ratio [HR] = 3.7, P = .03) and autologous blood or marrow transplantation survivors (HR = 2.6, P = .048). (ascopost.com)
  • Compared with the general population, exposure to total-body irradiation among individuals younger than 30 was associated with significantly increased risk of breast cancer among both allogeneic blood or marrow transplantation survivors (standardized incidence ratio [SIR] = 4.4) and autologous blood or marrow transplantation survivors (SIR = 4.6). (ascopost.com)
  • Experience with haploidentical stem cell transplantation in elderly patients after non TBI (total body irradiation) containing regimens is limited. (aspergillus.org.uk)
  • Ninety-four consecutive patients with chronic myelogenous leukemia in first clinical chronic phase, median age of 34.0 years (range, 6.8 to 52.4 years), with a histocompatible sibling donor, were treated with fractionated total body irradiation (1,320 cGy) and high-dose etoposide (60 mg/kg) followed by allogeneic bone marrow transplantation (BMT). (duke.edu)
  • Total body irradiation (TBI) is commonly used in conditioning regimens prior to allogeneic bone marrow transplantation (alloBMT) in the treatment of a variety of malignant and non-malignant disorders ( Wheldon and Barrett, 2001 ). (frontiersin.org)
  • Total body irradiation (TBI) with megavoltage photon beam is most commonly used as part of the conditioning region for bone marrow transplantation, which is used in the treatment of variety of diseases, such as leukemia, aplastic anemia, lymphoma, multiple myeloma, autoimmune diseases and inborn errors of metabolism. (rwjbh.org)
  • The importance of age, fludarabine and total body irradiation in the incidence and severity of chronic renal failure following allogeneic hematopoietic stem cell transplantation. (ucl.ac.uk)
  • Total body irradiation (TBI) is often used in combination with chemotherapy prior to bone marrow transplantation (BMT) for a number of malignant conditions and a few non-cancerous diseases. (lionscancercontrol.org)
  • Hematopoietic stem cell (HSC) transplantation is a desirable treatment for many non-malignant and malignant diseases, but its use requires preconditioning of recipients with irradiation or chemotherapy that often induces high toxicity. (nature.com)
  • Total-body irradiation (TBI) is a major constituent of myeloablative conditioning regimens. (bioportfolio.com)
  • Because CLL is a highly radiosensitive cancer, we hypothesized that total body irradiation (TBI) conditioning regimens may be associated with better outcomes than those without TBI. (elsevier.com)
  • Some preparative regimens include total body irradiation (TBI). (bmtinfonet.org)
  • Before your transplant, you will receive chemotherapy and/or total body irradiation to prepare your body to receive healthy blood stem cells. (bmtinfonet.org)
  • If you're having an allogeneic stem cell transplant (getting bone marrow or stem cells from a donor), your body may see the cells as foreign. (mskcc.org)
  • Giving total-body irradiation (TBI) before a donor bone marrow transplant using stem cells that closely match the patient's stem cells, helps stop the growth of abnormal cells. (clinicaltrials.gov)
  • Giving chemotherapy and total-body irradiation before a donor stem cell transplant helps stop the growth of cells in the bone marrow, including normal blood-forming cells (stem cells) and cancer cells. (centerwatch.com)
  • The stem cells that were collected from the patient's blood or bone marrow are returned to the patient to replace the blood-forming cells that were destroyed by the chemotherapy and total-body irradiation. (mayo.edu)
  • Although some studies have demonstrated that ionizing radiation can induce apoptosis and senescence in hematopoietic stem cells, little is known about the effects of total body irradiation (TBI) on bone marrow (BM) mesenchymal stem cells (MSC). (haematologica.org)
  • As you know Jake had Total Body Irradiation (TBI) which wiped out his bone marrow. (jakestake.tv)
  • These will repopulate his bone marrow and get his body making blood cells again. (jakestake.tv)
  • If you are getting bone marrow or stem cells from a donor, your body may see these as foreign. (rwjbh.org)
  • This is rarely done, but you may get radiation to your whole body to help kill your bone marrow cells and any leukemia cells. (ahealthyme.com)
  • A high-energy x-ray beam under exacting geometrical alignment, radiates the patient's entire body to suppress their bone marrow allowing for the later transplant of healthy marrow. (nyp.org)
  • Total body irradiation (TBI) is used in combination with chemotherapy to prepare patients with leukemia for stem cell and bone marrow transplant. (uky.edu)
  • SBRT may produce abscopal effects where tumors outside the irradiation area also demonstrate tumor shrinkage in some occurrences. (clinicaltrials.gov)
  • Similarly, good results have been shown for SBRT in the re-irradiation of head and neck tumors. (biomedcentral.com)
  • SBRT re-irradiation after primary SBRT should not be practiced in centrally located tumors due to high risk of severe toxicity. (biomedcentral.com)
  • Only limited data is available for SBRT re-irradiation of pelvic tumors: feasibility and acceptable toxicity has been described, suggesting SBRT as a complementary treatment modality for local symptom control. (biomedcentral.com)
  • Here, we evaluated the utility of combined whole body irradiation and agonist anti-CD40 antibody to enhance ACT-mediated control of established autochthonous pancreatic tumors. (biomedcentral.com)
  • Stereotactic body radiation therapy (SBRT) is used to treat tumors outside of the brain and spine. (uky.edu)
  • Other etiologies of small bowel obstruction include disease intrinsic to the wall of the small intestine (eg, tumors, stricture, intramural hematoma) and processes that cause intraluminal obstruction (eg, intussusception, gallstones, foreign bodies). (uptodate.com)
  • These changes lasted throughout the 6 months observation period, showing that irradiation induces long term effects on the generation of the NK cell receptor repertoire. (frontiersin.org)
  • We especially focus on how local irradiation induces abscopal effects. (frontiersin.org)
  • Taken together these data strongly suggest that irradiation induces a marked increase in CD31 expression on endothelial cells as part of a general response to irradiation. (ahajournals.org)
  • Giving chemotherapy and total-body irradiation before a stem cell transplant stops the growth of cancer cells by stopping them from dividing or killing them. (mayo.edu)
  • Ablative strategies to treat patients with oligometastases from sarcomas yield prolonged survival times and stereotactic body radiation therapy (SBRT) is associated with excellent tolerance. (clinicaltrials.gov)
  • SBRT produces systemic antitumoral immune response in certain conditions and enhances radiation-induced tumor cell death compared to conventional lower dose irradiation. (clinicaltrials.gov)
  • Recently, several studies reported re-irradiation for spinal metastases using SBRT with promising local and symptom control rates and simultaneously low rates of toxicity. (biomedcentral.com)
  • Few studies with small patient numbers have been published on SBRT re-irradiation for non-small cell lung cancer (NSCLC). (biomedcentral.com)
  • Conclusion: Definitive fractionated re-irradiation is thought to be a safe alternative therapy for local recurrence following SBRT, although its efficacy may be not entirely satisfactory. (elsevier.com)
  • Between 2011 and 2015, 28 patients with imaged and/or biopsy-proven intra-prostatic recurrence of cancer after definitive radiation therapy underwent a salvage re-irradiation using HDRB ( n = 10) or focal SBRT ( n = 18). (biomedcentral.com)
  • Salvage prostate re-irradiation for locally recurrent cancer is feasible and generate low toxicities rates when using with HDRB or focal SBRT. (biomedcentral.com)
  • This effect may be used in polycythaemic mice to estimate changes in the erythropoietin-sensitive stem-cell population following total-body irradiation (TBR). (osti.gov)
  • In this study, both the Gompertz and "probacent" models are applied to the Sacher's comprehensive experimental data on survival times of mice daily exposed to various doses of total body irradiation until death occurs with an assumption that each of both models is applicable to the data. (scirp.org)
  • The purpose of this study is to construct general formulas expressing relationship between dose rate and survival time in total body irradiation in mice. (scirp.org)
  • Dose-response curves obtained 1 and 3 days after exposure to total-body X irradiation indicate that the mononuclear cells in the circulating blood and in the peritoneal cavity of LAF sub1 mice may be arranged in the following order of decreasing sensitivity: circulating lymphocytes, small peritoneal lymphocytes, medium peritoneal lymphocytes, peritoneal macrophages. (dtic.mil)
  • The acute effects of variable dos rates to total body irradiation (TBI) were investigated with 600 cgy of single exposure in the mice as a preclinical model. (koreamed.org)
  • The radiation-induced mortality together with the loss of body-weight and development of radiation sickness was studied in young adult Swiss albino mice after exposure to 1500 R of 60Co gamma-radiation in the presence and absence of 2-mercaptopropionyl-glycine (MGP), and results from both the groups were compared. (semanticscholar.org)
  • irradiation in mice via restoration of hematopoietic tissues. (rtrn.net)
  • The uncertainties in patient localization and intrafraction motion of the whole body during hour-long TMI treatment may pose a risk to the safety and accuracy of targeted radiation treatment. (spiedigitallibrary.org)
  • The OTS may be optimized to monitor whole body motion during TMI to increase the accuracy of treatment delivery and reduce the radiation dose to the lungs. (spiedigitallibrary.org)
  • The apparent ability of rats to voluntarily select a dietary according to the needs of the body was utilized in a study to detect possible metabolic derangements subsequent to a dose of 375 rad whole-body X-irradiation. (dtic.mil)
  • The goal of part II of this study was to evaluate the effects of gamma-radiation on circulating blood cells, functional characteristics of splenocytes, and cytokine expression after whole-body irradiation at varying total doses and at low- and high-dose-rates (LDR, HDR). (nasa.gov)
  • A lesion simulating intracerebral haemorrhage was produced in the right caudate nucleus of rats immunosuppressed with whole body or regional irradiation. (springer.com)
  • Whole body irradiation produced significant leucopaenia and thrombocytopaenia and conferred protection against cerebral ischaemia and oedema when compared to nonirradiated control animals. (springer.com)
  • Kane P.J., Modha P., Strachan R.D., Mendelow A.D., Cook S., Chambers I.R. (1990) The Effect of Immunosuppression with Whole Body and Regional Irradiation on the Development of Cerebral Oedema in a Rat Model of Intracerebral Haemorrhage. (springer.com)
  • 2) Whole-body x-irradiation induced a change in the synthetic pattern of hepatic fatty acids towards a relatively enhanced synthesis of palmitic acid. (dtu.dk)
  • The effect of leukopenia on the susceptibility of rabbits to the localized Shwartzman reaction was studied in those receiving whole body irradiation and nitrogen mustard respectively. (rupress.org)
  • From the findings, it is concluded ( a ) that the presence of normal numbers of circulating polymorphonuclear leukocytes is not an obligatory prerequisite condition to the localized hemorrhagic necrosis of the Shwartzman phenomenon, and ( b ) the mechanisms of action of nitrogen mustard and whole body irradiation on body tissues differ in relation to the Shwartzman reaction. (rupress.org)
  • Radiation beams are aimed at your whole body to help slow down your immune system . (webmd.com)
  • Here, we assessed the efficacy of sublethal whole-body irradiation (WBI) to enhance the magnitude and duration of adoptively transferred CD8 + T cells in the transgenic adenocarcinoma of the mouse prostate (TRAMP) model. (aacrjournals.org)
  • Whole-Body Irradiation" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (rtrn.net)
  • Irradiation of the whole body with ionizing or non-ionizing radiation. (rtrn.net)
  • This graph shows the total number of publications written about "Whole-Body Irradiation" by people in this website by year, and whether "Whole-Body Irradiation" was a major or minor topic of these publications. (rtrn.net)
  • Below are the most recent publications written about "Whole-Body Irradiation" by people in Profiles. (rtrn.net)
  • Purgason A, Zhang Y, Hamilton SR, Gridley DS, Sodipe A, Jejelowo O, Ramesh GT, Moreno-Villanueva M, Wu H. Apoptosis and expression of apoptosis-related genes in mouse intestinal tissue after whole-body proton exposure. (rtrn.net)
  • In contrast, combined whole body irradiation and anti-CD40 prolonged T cell proliferation in the tumor draining lymph node and dramatically increased accumulation of interferon gamma-producing, PD-1 lo donor T cells in the pancreas. (biomedcentral.com)
  • This study explored the effects of whole-body proton radiation on uterine smooth muscle known as the myometrium. (etsu.edu)
  • You may get radiation to your whole body to help kill hiding leukemia cells. (ahealthyme.com)
  • If you're getting TBI as part of stem cell transplant, your whole body will be treated. (ahealthyme.com)
  • Enhanced mitogen-induced proliferation of rat splenocytes by low-dose whole-body X-irradiation. (elsevier.com)
  • To elucidate the stimulative effect on the immune system, we studied the effect of acute low-dose whole-body X-irradiation on the mitogen-induced proliferative responses of rat splenocytes and thymocytes. (elsevier.com)
  • This phase II trial studies how well tacrolimus and mycophenolate mofetil works in preventing graft-versus-host disease in patients who have undergone total-body irradiation (TBI) with or without fludarabine phosphate followed by donor peripheral blood stem cell transplant for hematologic cancer. (clinicaltrials.gov)
  • In this study we plan to determine the maximum feasible dose (MFD) of Clofarabine in combination with total body irradiation that can achieve durable donor engraftment without causing excessive toxicity. (bioportfolio.com)
  • This study is being done to learn whether a new method to prevent rejection between the donor immune system and the patient's body is effective. (bioportfolio.com)
  • This clinical trial studies the side effects and best dose of giving fludarabine and total-body irradiation (TBI) together followed by a donor stem cell transplant and cyclosporine and mycophenolate mofetil in treating human immunodeficiency virus (HIV)-positive patients with or without cancer. (nih.gov)
  • Provided that irradiation does not cause irreversible impairment of bowel function, adjunctive immunosuppressive therapy with donor WBI may provide a significant benefit in allowing lower initial doses of CsA followed by more rapid tapering. (elsevier.com)
  • however, the long-term effects of irradiation with aging remain unclear. (jimmunol.org)
  • Given the potential multifunctional role of CD31 in the vasculature we have examined the possible effects of irradiation on levels of CD31 expression in HUVECs. (ahajournals.org)
  • Taken together, these data suggest that long-term suppression of thymopoiesis after sublethal irradiation was primarily due to fewer progenitors in the BM combined with reduced potential for T lineage commitment. (jimmunol.org)
  • 48 patients with 'active' CLL were treated with TBI and were compared with 18 patients treated with chemotherapy and/or local irradiation. (osti.gov)
  • misc{etde_7341189, title = {Total body irradiation (TBI) of chronic lymphocytic leukemia (CLL)} author = {Ruehl, U, and Johnson, R E} abstractNote = {80 patients with previously untreated CLL have been admitted to the Radiation Oncology Branch of the NCI. (osti.gov)
  • This page has been produced to provide information about total body irradiation (TBI) and aims to answer some of the questions often asked by patients and their carers. (newcastle-hospitals.org.uk)
  • Patients undergo total body irradiation (TBI) on day -1. (centerwatch.com)
  • Patients receive graft-versus-host disease prophylaxis, CNS prophylaxis, and testicular irradiation as per institutional standard practices. (knowcancer.com)
  • About 50 percent of [BMT] transplant patients overall receive total body irradiation, including a higher proportion of those patients who are younger," Bhatia said. (uab.edu)
  • Background and Objectives Ionizing irradiation is a common treatment for cancer patients and can result in adverse side effects affecting the bone and hematopoietic systems. (haematologica.org)
  • Ionizing irradiation is a common treatment for cancer patients. (haematologica.org)
  • Patients who had received pretransplant chest irradiation or who had a history of breast cancer were excluded. (ascopost.com)
  • It is determined that while all doses fall within prescription, there is a trend where smaller patients receive lower mean body doses and viceversa (mean body dose range: 10.93-12.01 Gy). (ubc.ca)
  • For most patients, the lungs and liver consistently receive doses below the mean body dose, and the thyroid and kidneys consistently receive higher doses than the mean body dose. (ubc.ca)
  • Patients who die from ciliary body melanoma die because of distant metastasis rather than local spread. (medscape.com)
  • Total body irradiation (TBI) is a radiation therapy used as part of treatment for patients with lymphoma, leukemia or myeloma. (nortonchildrens.com)
  • Definitive fractionated re-irradiation was performed for 17 out of the 46 patients. (elsevier.com)
  • Local salvage procedures such as radical prostatectomy, high-intensity ultrasounds ablation (HIFU), cryosurgery or prostate re-irradiation [ 5 - 8 ] are therapy alternatives that can be offered to highly selected patients. (biomedcentral.com)
  • The adoption of hypofractionated whole-breast irradiation (HF-WBI) remains low, in part because of concerns regarding its safety when used with a tumor bed boost or in patients who have received chemotherapy or have large breast size. (nih.gov)
  • The effect of 150 rad TBR on the erythropoietin-sensitive stem-cell population is an initial depression within 30 min to 20% of normal followed by a second depression (post-irradiation dip) at about 12 h. (osti.gov)
  • These alterations, sustained up to 28 days post-irradiation, were independent of cellular senescence in BM MSC. (haematologica.org)
  • A method and an apparatus for the substantially uniform irradiation of the entire area of cavities from the inside. (google.ca)
  • The present invention relates to a method and to an apparatus for the substantially uniform irradiation of the entire area of cavities from the inside. (google.ca)
  • Then, the probe contains laser light scattering particles for uniform irradiation of the laser light against the tissues. (google.com.au)
  • Additionally, high doses of total body irradiation can eradicate residual cancer cells in the transplant recipient, increasing the likelihood that the transplant will be successful. (wikipedia.org)
  • In modern practice, total body irradiation is typically fractionated, with smaller doses delivered in several sessions, rather than delivering the entire dose at once. (wikipedia.org)
  • The supine and prone dose distributions are summed with a deformable registration tool and the doses to the lungs, kidneys, thyroid, and liver are analyzed as well as the dose delivered to the body. (ubc.ca)
  • This sends radiation in equal doses to all parts of your body. (ahealthyme.com)
  • Hypothesis: Myeloablative conditioning using a dose escalation of clofarabine in combination with cytarabine (ARA-C) and total body irradiation (TBI) will lead to improved survival for pre. (bioportfolio.com)
  • Does total body irradiation conditioning improve outcomes of myeloablative human leukocyte antigen-identical sibling transplantations for chronic lymphocytic leukemia? (elsevier.com)
  • Exposure to irradiation 30 min prior to antigen administration resulted in an extension of the second phase by 2 days as compared to the controls, with the onset of the third phase occurring on day 7. (springer.com)
  • The "probacent" model might be hopefully helpful in research in human tolerance to low dose rates for long durations of exposure in total body irradiation, and further in research in a variety of biomedical phenomena. (scirp.org)
  • The death rate of the "probacent" model developed by the author based on animal experiments, clinical applications and mathematical reasoning was applied to predict age-specific death rates in the US elderly population, 2001, and to express a relationship among dose rate, duration of exposure and mortality probability in total body irradiation in humans. (scirp.org)
  • The investigators concluded, "The association between [total-body irradiation] and subsequent breast cancer, especially among those exposed at a young age, as well as pre[transplant] exposure to alkylating agents, should inform breast cancer screening for early detection. (ascopost.com)
  • They are produced by the white blood cells known as lymphocytes in response to exposure to the antigens of the foreign body against which they act. (leukaemia.org.au)
  • At the start of the treatment session, a radiation therapist helps you get into position and may use blocks or special shields to protect parts of your body from exposure to radiation. (ahealthyme.com)
  • Acute myelosuppression is the primary cause of death after accidental or intentional exposure to a high dose of total body irradiation (TBI) [ 2 , 3 ]. (mdpi.com)
  • Uveal melanomas are the most common primary intraocular malignancies and the second most common type of primary malignant melanoma in the body. (medscape.com)
  • RWJUH is one of the only hospitals in the Northeast to offer Total Body Irradiation (TBI) for the treatment of various malignancies. (rwjbh.org)
  • This phase I/II trial studies the side effects and best dose of bortezomib when given together with melphalan, and total-body irradiation before stem cell transplant and to see how well it. (bioportfolio.com)
  • Drug: Fludarabine and Busulfan plus/minus Total Body Irradiation (low dose) Fludarabine 40mg/m2 and Busulfan 130mg/m2 on days -6, -5, -4 and -3 of transplant. (aamds.org)
  • If you need to have a transplant, you may have total body irradiation (TBI). (ahealthyme.com)
  • If you're having total body irradiation as part of a stem cell transplant, you will stand in a special machine or lie down on either your stomach or your back. (ahealthyme.com)
  • Several days prior to your transplant, you will receive high-dose chemotherapy and/or total body irradiation (TBI). (bmtinfonet.org)
  • We eliminate all traces of lymphoma from all over your body in preparation for a stem cell transplant . (uvahealth.com)
  • In the present study, we presented an ATM attack developed after total body irradiation (TBI) in an acute lymphoblastic leukemia (ALL) case, as it has not been found in the literature so far. (hindawi.com)
  • Ciliary body melanomas can push the iris diaphragm anteriorly, or they can infiltrate the trabecular meshwork, producing acute angle closure. (medscape.com)
  • Tom Lowe joined us today to discuss his work with ultraviolet blood irradiation and ozone therapy for human health. (extremehealthradio.com)
  • Ultraviolet blood irradiation goes by other names like biophotonic therapy, UBI, ultraviolet light therapy, ultraviolet phototherapy, photophereisis, extracorporeal therapy and photodynamic therapy. (extremehealthradio.com)
  • Why don't you hear about ultraviolet blood irradiation therapy? (extremehealthradio.com)
  • Just because your doctor doesn't know about ultraviolet blood irradiation, that doesn't mean it doesn't exist or it doesn't work. (extremehealthradio.com)
  • I hope you enjoy this show with Tom Lowe about ultraviolet blood irradiation . (extremehealthradio.com)
  • Furthermore, it has been claimed that ultraviolet irradiation of blood kills bacteria by DNA damage and also activation of the immune system. (wikipedia.org)
  • This method is used for the ultraviolet (UV) blood irradiation (UVBI) by UV lamps. (wikipedia.org)
  • Total skin electron irradiation (TSEI) is a treatment for a rare, generally incurable type of lymphoma called mycosis fungoides. (uky.edu)
  • Learn more about total skin electron irradiation. (uky.edu)
  • A laser light irradiation apparatus used for medical treatment of tissues. (google.com.au)
  • Total body irradiation and chemotherapeutic exposures such as alkylating agents and anthracyclines are used to prepare the patient for BMT. (uab.edu)
  • Animal studies have shown that irradiation produces immediate endothelial damage, with uniform impairment of response to acetylcholine, serotonin, and nitroglycerin demonstrated immediately after radiation damage. (ahajournals.org)
  • In this study irradiation of human umbilical vein endothelial cells (HUVECs) significantly increased adherence of U-937 cells in a time-dependent manner. (ahajournals.org)
  • 8 Recent experimental evidence suggests that radiation-induced expression of the membrane glycoproteins E-selectin and intercellular adhesion molecule 1 (ICAM-1) on endothelial cells is involved in the mechanisms mediating increased leukocyte-endothelial cell interactions after irradiation. (ahajournals.org)