A widely used local anesthetic agent.
Drugs that block nerve conduction when applied locally to nerve tissue in appropriate concentrations. They act on any part of the nervous system and on every type of nerve fiber. In contact with a nerve trunk, these anesthetics can cause both sensory and motor paralysis in the innervated area. Their action is completely reversible. (From Gilman AG, et. al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed) Nearly all local anesthetics act by reducing the tendency of voltage-dependent sodium channels to activate.
Procedure in which an anesthetic is injected directly into the spinal cord.
The relief of pain without loss of consciousness through the introduction of an analgesic agent into the epidural space of the vertebral canal. It is differentiated from ANESTHESIA, EPIDURAL which refers to the state of insensitivity to sensation.
Organic compounds containing the -CO-NH2 radical. Amides are derived from acids by replacement of -OH by -NH2 or from ammonia by the replacement of H by an acyl group. (From Grant & Hackh's Chemical Dictionary, 5th ed)
The elimination of PAIN, without the loss of CONSCIOUSNESS, during OBSTETRIC LABOR; OBSTETRIC DELIVERY; or the POSTPARTUM PERIOD, usually through the administration of ANALGESICS.
Procedure in which an anesthetic is injected into the epidural space.
A variety of anesthetic methods such as EPIDURAL ANESTHESIA used to control the pain of childbirth.
Interruption of NEURAL CONDUCTION in peripheral nerves or nerve trunks by the injection of a local anesthetic agent (e.g., LIDOCAINE; PHENOL; BOTULINUM TOXINS) to manage or treat pain.
A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more prolonged than those of PROCAINE but its duration of action is shorter than that of BUPIVACAINE or PRILOCAINE.
Pain during the period after surgery.
Epidural anesthesia administered via the sacral canal.
A local anesthetic with rapid onset and long action, similar to BUPIVACAINE.
A blocking of nerve conduction to a specific area by an injection of an anesthetic agent.
An opioid analgesic that is used as an adjunct in anesthesia, in balanced anesthesia, and as a primary anesthetic agent.
A potent narcotic analgesic, abuse of which leads to habituation or addiction. It is primarily a mu-opioid agonist. Fentanyl is also used as an adjunct to general anesthetics, and as an anesthetic for induction and maintenance. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1078)
The use of two or more chemicals simultaneously or sequentially to induce anesthesia. The drugs need not be in the same dosage form.
A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment.
Agents that are administered in association with anesthetics to increase effectiveness, improve delivery, or decrease required dosage.
A local anesthetic that is chemically related to BUPIVACAINE but pharmacologically related to LIDOCAINE. It is indicated for infiltration, nerve block, and epidural anesthesia. Mepivacaine is effective topically only in large doses and therefore should not be used by this route. (From AMA Drug Evaluations, 1994, p168)
Introduction of therapeutic agents into the spinal region using a needle and syringe.
Extraction of the FETUS by means of abdominal HYSTEROTOMY.
A thiophene-containing local anesthetic pharmacologically similar to MEPIVACAINE.
Compounds with activity like OPIATE ALKALOIDS, acting at OPIOID RECEPTORS. Properties include induction of ANALGESIA or NARCOSIS.
Scales, questionnaires, tests, and other methods used to assess pain severity and duration in patients or experimental animals to aid in diagnosis, therapy, and physiological studies.
Methods of PAIN relief that may be used with or in place of ANALGESICS.
The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)
The process in which specialized SENSORY RECEPTOR CELLS transduce peripheral stimuli (physical or chemical) into NERVE IMPULSES which are then transmitted to the various sensory centers in the CENTRAL NERVOUS SYSTEM.
The space between the arachnoid membrane and PIA MATER, filled with CEREBROSPINAL FLUID. It contains large blood vessels that supply the BRAIN and SPINAL CORD.
Relief of PAIN, without loss of CONSCIOUSNESS, through ANALGESIC AGENTS administered by the patients. It has been used successfully to control POSTOPERATIVE PAIN, during OBSTETRIC LABOR, after BURNS, and in TERMINAL CARE. The choice of agent, dose, and lockout interval greatly influence effectiveness. The potential for overdose can be minimized by combining small bolus doses with a mandatory interval between successive doses (lockout interval).
The principal alkaloid in opium and the prototype opiate analgesic and narcotic. Morphine has widespread effects in the central nervous system and on smooth muscle.
The large network of nerve fibers which distributes the innervation of the upper extremity. The brachial plexus extends from the neck into the axilla. In humans, the nerves of the plexus usually originate from the lower cervical and the first thoracic spinal cord segments (C5-C8 and T1), but variations are not uncommon.
The repetitive uterine contraction during childbirth which is associated with the progressive dilation of the uterine cervix (CERVIX UTERI). Successful labor results in the expulsion of the FETUS and PLACENTA. Obstetric labor can be spontaneous or induced (LABOR, INDUCED).
The relationship between the dose of an administered drug and the response of the organism to the drug.
A local anesthetic of the ester type that has a slow onset and a short duration of action. It is mainly used for infiltration anesthesia, peripheral nerve block, and spinal block. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1016).
The injection of drugs, most often analgesics, into the spinal canal without puncturing the dura mater.
Surgery performed on an outpatient basis. It may be hospital-based or performed in an office or surgicenter.
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
A local anesthetic that is similar pharmacologically to LIDOCAINE. Currently, it is used most often for infiltration anesthesia in dentistry.
The active sympathomimetic hormone from the ADRENAL MEDULLA. It stimulates both the alpha- and beta- adrenergic systems, causes systemic VASOCONSTRICTION and gastrointestinal relaxation, stimulates the HEART, and dilates BRONCHI and cerebral vessels. It is used in ASTHMA and CARDIAC FAILURE and to delay absorption of local ANESTHETICS.
The ratio of the density of a material to the density of some standard material, such as water or air, at a specified temperature.
A nerve which originates in the lumbar and sacral spinal cord (L4 to S3) and supplies motor and sensory innervation to the lower extremity. The sciatic nerve, which is the main continuation of the sacral plexus, is the largest nerve in the body. It has two major branches, the TIBIAL NERVE and the PERONEAL NERVE.
Surgical incision into the chest wall.
An abdominal hernia with an external bulge in the GROIN region. It can be classified by the location of herniation. Indirect inguinal hernias occur through the internal inguinal ring. Direct inguinal hernias occur through defects in the ABDOMINAL WALL (transversalis fascia) in Hesselbach's triangle. The former type is commonly seen in children and young adults; the latter in adults.
An opioid analgesic made from MORPHINE and used mainly as an analgesic. It has a shorter duration of action than morphine.
Narcotic analgesic related to CODEINE, but more potent and more addicting by weight. It is used also as cough suppressant.
A short-acting beta-2 adrenergic agonist that is primarily used as a bronchodilator agent to treat ASTHMA. Albuterol is prepared as a racemic mixture of R(-) and S(+) stereoisomers. The stereospecific preparation of R(-) isomer of albuterol is referred to as levalbuterol.
An opioid analgesic with actions and uses similar to those of MORPHINE, apart from an absence of cough suppressant activity. It is used in the treatment of moderate to severe pain, including pain in obstetrics. It may also be used as an adjunct to anesthesia. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1092)
Derivatives of the steroid androstane having two double bonds at any site in any of the rings.
The action of a drug that may affect the activity, metabolism, or toxicity of another drug.
An acute hypersensitivity reaction due to exposure to a previously encountered ANTIGEN. The reaction may include rapidly progressing URTICARIA, respiratory distress, vascular collapse, systemic SHOCK, and death.
Acquired or developmental conditions marked by an impaired ability to comprehend or generate spoken forms of language.
A syndrome of ORTHOSTATIC INTOLERANCE combined with excessive upright TACHYCARDIA, and usually without associated ORTHOSTATIC HYPOTENSION. All variants have in common an excessively reduced venous return to the heart (central HYPOVOLEMIA) while upright.
An imprecise term which may refer to a sense of spatial disorientation, motion of the environment, or lightheadedness.
Spherical particles of nanometer dimensions.
Cyclical movement of a body part that can represent either a physiologic process or a manifestation of disease. Intention or action tremor, a common manifestation of CEREBELLAR DISEASES, is aggravated by movement. In contrast, resting tremor is maximal when there is no attempt at voluntary movement, and occurs as a relatively frequent manifestation of PARKINSON DISEASE.
... thereby providing about twice the alignment correction of bupivacaine alone. The effectiveness of a bupivacaine injection may ... After bupivacaine injection the muscle is inactivated by the drug's anesthetic effect for a day, and weakened by myofiber ... If bupivacaine injection is combined with a small dose of botulinum toxin in the antagonist muscle, eye deviation during ... Bupivacaine injection is not effective in paralyzed or atrophic muscles, or where there are restrictions to movement elsewhere ...
Examples include lidocaine and bupivacaine. Passerini reaction Ugi I, Meyr R, Fetzer U, Steinbrückner C (1959). "Versuche mit ...
Compared to bupivacaine, levobupivacaine is associated with less vasodilation and has a longer duration of action. It is ... It is the S-enantiomer of bupivacaine. Levobupivacaine hydrochloride is commonly marketed by AbbVie under the trade name ... ISBN 0-9757919-2-3 Gulec D, Karsli B, Ertugrul F, Bigat Z, Kayacan N (April 2014). "Intrathecal bupivacaine or levobupivacaine ... Systemic exposure to excessive quantities of bupivacaine mainly result in central nervous system (CNS) and cardiovascular ...
Marcaine/Sensorcaine (bupivacaine). *Naropin (ropivacaine). *Xylocaine (lidocaine). *Xyloproct (lidocaine/hydrocortisone). - ...
... or an incorrectly administered drug such as bupivacaine.[citation needed] One of the ways to detect cardiotoxicity at early ...
Bupivacaine is a safe alternative in this case. Impaired liver function - people with lowered hepatic function may have an ... Longer-acting substances such as bupivacaine are sometimes given preference for spinal and epidural anaesthesias; lidocaine, ...
Punke MA, Licher T, Pongs O, Friederich P (Jun 2003). "Inhibition of human TREK-1 channels by bupivacaine". Anesthesia and ... Bupivacaine Quinidine Fluoxetine Seproxetine (Norfluoxetine) 12-O-tetradecanoylphorbol-13-acetate (TPA) (phorbol 12-myristate ...
In some interventions bupivacaine has been used alone. In others, a botulinum toxin injection into an extraocular muscle is ... The thickening of bupivacaine-injected extraocular muscle has been demonstrated by means of magnetic resonance imaging and by ... Bupivacaine is a local anaesthetic known to cause considerable myotoxicity and neurotoxicity. Its injection into muscle tissue ... Scott, AB; Miller, JM; Shieh, KR (April 2009). "Bupivacaine injection of the lateral rectus muscle to treat esotropia". J AAPOS ...
Punke MA, Licher T, Pongs O, Friederich P (June 2003). "Inhibition of human TREK-1 channels by bupivacaine". Anesthesia and ...
Bupivacaine injection stresses a muscle and triggers a growth process, analogous to how load-bearing exercise builds skeletal ... Clinical studies over the past decade have demonstrated that bupivacaine injection in a weak muscle has a synergistic effect ... Miller, J. M.; Scott, A. B.; Danh, K. K.; Strasser, D.; Sane, M. (2013). "Bupivacaine injection remodels extraocular muscles ... Scott is therefore now developing the anesthetic drug bupivacaine as an injection to strengthen and shorten weak muscles. ...
BUPIVA CAINE HYDROCHLORIDE 72. BUPROPION 73. BUSPIRONE 74. BUTENAFINE HYDROCHLORIDE 75. BUTORPHANOL TARTRATE ...
And last but not least, some degree of improving in therapeutic index of NSTX can be observed when is mixed with bupivacaine ... Padera R, Bellas E, Tse JY, Hao D, Kohane DS (May 2008). "Local Myotoxicity from Sustained Release of Bupivacaine from ... Beilin Y, Halpern S (August 2012). "Focused review: ropivacaine versus bupivacaine for epidural labor analgesia". Anesthesia & ... Additionally, two human reports demonstrated strong potentiation between NSTX anesthetic effect, bupivacaine and epinephrine. ...
Bupivacaine Plecko B, Hikel C, Korenke GC, et al. (2005). "Pipecolic acid as a diagnostic marker of pyridoxine-dependent ...
The amides include lidocaine, mepivacaine, prilocaine, bupivacaine, ropivacaine, and levobupivacaine. Chloroprocaine is a short ... bupivacaine, and mepivacaine. These drugs are often combined with adjuvants (additives) with the end goal of increasing the ... drug (45-90 minutes), lidocaine and mepivacaine are intermediate duration (90-180 minutes), and bupivacaine, levobupivacaine, ...
It is reported that seizures are more likely to occur when bupivacaine is used, particularly in combination with chloroprocaine ... Lidocaine can be safely used but bupivacaine and mepivacaine should be avoided. Consultation with the obstetrician is vital ... Weinberg G, Ripper R, Feinstein DL, Hoffman W (2003). "Lipid emulsion infusion rescues dogs from bupivacaine-induced cardiac ... Although all local anesthetics potentially shorten the myocardial refractory period, bupivacaine blocks the cardiac sodium ...
As for bupivacaine, Celepid, a commonly available intravenous lipid emulsion, can be effective in treating severe ... Weinberg G, Ripper R, Feinstein DL, Hoffman W (2003). "Lipid emulsion infusion rescues dogs from bupivacaine-induced cardiac ... Ropivacaine was developed after bupivacaine was noted to be associated with cardiac arrest, particularly in pregnant women. ... Ropivacaine was found to have less cardiotoxicity than bupivacaine in animal models. Ropivacaine is contraindicated for ...
Weinberg G, Ripper R, Feinstein DL, Hoffman W (2003). "Lipid emulsion infusion rescues dogs from bupivacaine-induced cardiac ... "Pretreatment or resuscitation with a lipid infusion shifts the dose-response to bupivacaine-induced asystole in rats". ... treating experimental models of severe cardiotoxicity from intravenous overdose of local anaesthetic drugs such as bupivacaine ...
Cardiotoxic local anesthetic agents like bupivacaine and etidocaine are strictly contraindicated. The safety and effectiveness ... However, cardiotoxic local anesthetic agents like bupivacaine and etidocaine are contraindicated. Shorter procedure times (for ...
Commercially significant derivatives are the anesthetics lidocaine, bupivacaine, mepivacaine, and etidocaine. Many xylidines ...
... by temporarily damaging muscle fibres with myotoxins such as bupivacaine; or 3) by using hypertonic solutions of saline or ...
"Hypercarbic and hypoxic ventilatory responses after intrathecal administration of bupivacaine and sameridine". Anesthesia and ...
A small dose of local anaesthetic (e.g. bupivacaine) is then instilled. An opioid such as fentanyl may also be given if desired ... It further recommends the use of bupivacaine and fentanyl to establish the block. Combined spinal-epidural anaesthesia is a ...
Paracaine, tetracaine, bupivacaine, lidocaine etc. may also be used in place of xylocaine. Cataract surgery by ...
Bupivacaine/meloxicam Use During Pregnancy and Breastfeeding Noble S, Balfour JA (March 1996). "Meloxicam". Drugs. 51 (3): 424- ...
For example, 0.1% bupivacaine may provide adequate analgesia for a woman in labour, but would likely be insufficient for ... Bupivacaine has caused several deaths by cardiac arrest when epidural anaesthetic has been accidentally inserted into a vein ... Bupivacaine is markedly toxic if inadvertently given intravenously, causing excitation, nervousness, tingling around the mouth ... Common local anaesthetics include lidocaine, mepivacaine, bupivacaine, ropivacaine, and chloroprocaine. Common opioids include ...
... like bupivacaine, pyrimethamine) are more charged inside the cell than outside. The cell membrane is permeable to non-ionized ( ...
A local anesthetic, like Bupivacaine, is injected into the area to numb the joint. The patient might feel a slight sting. ...
"Efficacy of Continuous Subacromial Bupivacaine Infusion for Pain Control After Arthroscopic Rotator Cuff Repair". Journal of ... "Efficacy of continuous subacromial bupivacaine infusion for pain control after arthroscopic rotator cuff repair". J Shoulder ...
"Placental transfer and neonatal effects of epidural sufentanil and fentanyl administered with bupivacaine during labor". ...
Long-acting bupivacaine can reduce treatment cost and be as effective as a femoral nerve block for pain relief from knee ... In the bupivacaine group, an intraoperative extended-release liposome injection of bupivacaine 266 mg was administered at the ... Extended-Release Bupivacaine vs Femoral Block In the second analysis, pain management was randomly assigned after knee ... Extended-release bupivacaine "has been an absolute game-changer as far as the control of pain," said Charles Lowry Barnes, MD, ...
Bupivacaine was discovered in 1957. It is on the World Health Organizations List of Essential Medicines. Bupivacaine is ... Bupivacaine is available as a generic medication. Levobupivacaine is the (S)-(-)-enantiomer of bupivacaine, with a longer ... Bupivacaine is contraindicated in patients with known hypersensitivity reactions to bupivacaine or amino-amide anesthetics. It ... Additionally, bupivacaine can cause chondrolysis after continuous infusion into a joint space. Bupivacaine has caused several ...
A list of US medications equivalent to Bupivacaine & Adrenaline 0.5% is available on the Drugs.com website. ... Bupivacaine & Adrenaline 0.5% is a medicine available in a number of countries worldwide. ... Bupivacaine. Bupivacaine hydrochloride monohydrate (a derivative of Bupivacaine) is reported as an ingredient of Bupivacaine & ... Bupivacaine & Adrenaline 0.5%. Bupivacaine & Adrenaline 0.5% may be available in the countries listed below. ...
bupivacaine synonyms, bupivacaine pronunciation, bupivacaine translation, English dictionary definition of bupivacaine. n. A ... bupivacaine. Also found in: Medical, Acronyms, Wikipedia.. Related to bupivacaine: lidocaine. bu·piv·a·caine (byo͞o-pĭv′ə-kān′) ... Call for quotations for the supply of bupivacaine 0.. Quotations For The Supply Of Bupivacaine 0.50 Percent And Adrenaline 1 In ... Levobupivacaine, the isolated S (-) enantiomer of Bupivacaine, has been shown to be less cardiotoxic than Bupivacaine in pre- ...
825 medications are known to interact with bupivacaine/hydromorphone. Includes Advair Diskus (fluticasone/salmeterol), AndroGel ... bupivacaine / hydromorphone alcohol/food Interactions. There is 1 alcohol/food interaction with bupivacaine / hydromorphone ... bupivacaine / hydromorphone disease Interactions. There are 19 disease interactions with bupivacaine / hydromorphone which ... Check for interactions with bupivacaine / hydromorphone. Type in a drug name and select a drug from the list. ...
Bupivacaine is used as a local (in only one area) anesthetic. Bupivacaine is given as an epidural injection into the spinal ... Bupivacaine is an anesthetic (numbing medicine) that blocks nerve impulses in your body. ... Bupivacaine is used as a local (in only one area) anesthetic. Bupivacaine is given as an epidural injection into the spinal ... Bupivacaine is also used as an anesthetic for dental procedures.. Bupivacaine may also be used for purposes not listed in this ...
Tell your doctor or nurse right away if you have the following symptoms with this medicine: anxiety; blurred vision; depression; drowsiness; lightheadedness; nausea or vomiting; numbness and tingling of the mouth or lips; restlessness; ringing in the ears; speech problems; or tremors. This medicine may cause serious allergic reactions, including anaphylaxis. Anaphylaxis can be life-threatening and requires immediate medical attention. Call your doctor right away if you have a rash; itching; fever; increased sweating; lightheadedness or fainting; trouble breathing; trouble swallowing; or any swelling of your hands, face, mouth, or throat after receiving this medicine. ...
... José Raul Soberón,1 Scott F. Duncan,2 and W. Charles Sternbergh3 ... K. Candiotti, "Liposomal bupivacaine: an innovative nonopioid local analgesic for the management of postsurgical pain," ... Pacira Pharmaceuticals Inc, EXPAREL (Bupivacaine Liposome Injectable Suspension) Prescribing Information, Pacira ...
Information about this bupivacaine-injection-route. Pregnancy Category. Explanation. All Trimesters. C. Animal studies have ... Appropriate studies have not been performed on the relationship of age to the effects of bupivacaine injection in the pediatric ... which may require caution and an adjustment in the dose for patients receiving bupivacaine injection. ... studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of bupivacaine ...
Bupivacaine Hydrochloride (UNII: 7TQO7W3VT8) (Bupivacaine - UNII:Y8335394RO) BUPIVACAINE HYDROCHLORIDE ANHYDROUS. 5 mg in 1 mL ... bupivacaine hydrochloride 5 MG/ML Injectable Solution. SCD. 3. 1012404. bupivacaine hydrochloride 0.5 % Injectable Solution. SY ... Continuous infusions of bupivacaine in children have been reported to result in high systemic levels of bupivacaine and ... After injection of Bupivacaine Hydrochloride for caudal, epidural, or peripheral nerve block in man, peak levels of bupivacaine ...
If you have an allergy to bupivacaine, epinephrine, or any other part of this drug. ...
No se debe utilizar esta información para decidir si se debe tomar este medicamento o cualquier otro. Solamente el proveedor de atención médica tiene el conocimiento y la capacitación para decidir qué medicamentos son adecuados para un paciente específico. Esta información no recomienda ningún medicamento como seguro, eficaz o aprobado para tratar a ningún paciente o enfermedad. Es solamente un breve resumen de información general sobre este medicamento. NO incluye toda la información sobre los usos, las instrucciones, las advertencias, las precauciones, las interacciones, los efectos secundarios o los riegos posibles que podrían aplicarse a este medicamento. Esta información no constituye asesoramiento médico específico y no reemplaza la información que usted recibe de su proveedor de atención médica. Debe hablar con el proveedor de atención médica para obtener información completa sobre los riesgos y los beneficios de tomar este medicamento.. ...
Get an overview of BUPIVACAINE HYDROCHLORIDE AND EPINEPHRINE (injection, solution), including warnings and precautions, ...
Find treatment reviews for Bupivacaine-Fentanyl from other patients. Learn from their experiences about effectiveness, side ... Bupivacaine-fentanyl is a narcotic analgesic combination medication used to treat pain, often through an epidural ...
Bupivacaine is an effective potassium channel blocker in heart.. Courtney KR1, Kendig JJ. ... The local anesthetic agent bupivacaine increases action potential duration in isolated frog atrial myocytes, and blocks two ...
Posted in Health Concerns, Pharmaceuticals, Product Recalls , Tagged 0.25% Bupivacaine Hydrochloride Injection, Bupivacaine ... Tag Archives: Bupivacaine Hydrochloride Injection. This page is having a slideshow that uses Javascript. Your browser either ... The voluntary recall affects one lot of 0.25% Bupivacaine Hydrochloride Injection, USP (NDC: 0409-1159-02, Lot 59-064- DK, ...
bupivacaine. UF studies anesthetic with potential for misuse in racehorses. April 16, 2019 ... The study will observe bupivacaine as there are concerns the extended release form of the drug could be used unethically to ... "Bupivacaine has been around for a while," says Taralyn McCarrel, DVM, an equine surgeon … ...
Effectiveness of Bupivacaine After Laparoscopic Cholecystectomy. The safety and scientific validity of this study is the ... Effectiveness of Bupivacaine After Laparoscopic Cholecystectomy. Official Title ICMJE Effectiveness for Postoperative Pain ... Group1: a bupivacaine 0,5% (2mg/kg) soaked-tabotamp is placed in gallbladder bed after remove of gallbladder ... Group1: a bupivacaine 0,5% (2mg/kg) soaked-tabotamp is placed in gallbladder bed after remove of gallbladder ...
Bupivacaine (By injection). Introduction. Bupivacaine (bue-PIV-a-kane). Used to numb an area of your body during surgery or ... Some medicines can affect how bupivacaine works. Tell your doctor if you are taking any of the following: *An MAO inhibitor ... Bupivacaine HCl Novaplus, Bupivacaine Spinal, Bupivilog Kit. ...
Dogs and pigs may differ in terms of susceptibility to bupivacaine cardiac toxicity; the porcine and canine models may not be ... They used a single 5 mg/kg IV bolus of bupivacaine, applied advanced cardiac life support 1 min after asystole, and ... We have recommended treating bupivacaine-associated cardiac arrest by injecting a 1 mL/kg bolus of 20% lipid emulsion (such as ... 1) also incorrectly cite us as indicating that "....a lipid infusion such as propofol increases the dose of bupivacaine ...
... By DrBicuspid Staff. November 12, 2018 -- The ADA has created a new Code on Dental ... Procedures and Nomenclature (CDT) for Exparel, a bupivacaine liposome injectable suspension from Pacira Pharmaceuticals. ...
Large Dose Bupivacaine 0.5% versus Small Dose in Elective Cesarean Section.. Ali HM1, Ismail AA1. ... In this study, we tried to solve this challenge by increasing the dose of bupivacaine to achieve a proper spinal level ... Large dose 15 mg of bupivacaine with the prolonged sitting position will lead to fewer incidences of hypotension and proper ... from large bupivacaine dose or insufficient satisfactory anesthesia level conditions as a result of small bupivacaine dose. ...
Background and objective We conducted a prospective double-blind randomized study assessing bupivacaine end-of-surgery wound ... Hosseini H, Abrisham SMJ, Jomeh H et al (2012) The comparison of intraarticular morphine-bupivacaine and tramadol-bupivacaine ... Chapman PJ (1987) Review: bupivacaine-a long-acting local anaesthetic. Aust Dent J 32:288-291CrossRefPubMedGoogle Scholar ... Tam K-W, Chen S-Y, Huang T-W et al (2015) Effect of wound infiltration with ropivacaine or bupivacaine analgesia in breast ...
Bupivacaine Liposome Injectable Suspension) may treat, uses, dosage, side effects, drug interactions, warnings, patient ... Bupivacaine is known to be substantially excreted by the kidney, and the risk of toxic reactions to bupivacaine may be greater ... Bupivacaine is present at a concentration of 13.3 mg/mL. After injection of EXPAREL into soft tissue, bupivacaine is released ... After bupivacaine has been released from EXPAREL and is absorbed systemically, bupivacaine excretion is expected to be the same ...
Group1: a bupivacaine 0,5% (2mg/kg) soaked-tabotamp is placed in gallbladder bed after remove of gallbladder ... Group1: a bupivacaine 0,5% (2mg/kg) soaked-tabotamp is placed in gallbladder bed after remove of gallbladder ... Verma GR, Lyngdoh TS, Kaman L, Bala I. Placement of 0.5% bupivacaine-soaked Surgicel in the gallbladder bed is effective for ... Bupivacaine. Anesthetics, Local. Anesthetics. Central Nervous System Depressants. Physiological Effects of Drugs. Sensory ...
Bupivacaine. Group: local anaesthetic agent. Injection (hydrochloride): 2.5 mg/ml (0.25%) or 5 mg/ml (0.5%) in 10-ml ampoule; 5 ... Bupivacaine injection should be kept protected from light and should not be allowed to freeze. Ampoules should not be used if ... Concentrations of bupivacaine greater than 0.5% are contraindicated for this purpose in view of reports of cardiac arrest and ... Bupivacaine is generally not recommended for children aged less than 12 years since there is insufficient information on the ...
Bupivacaine with Epinephrine Injection. Products Affected - Description. * *Bupivacaine (with epinephrine 1:200,000) injection ... The 0.25% bupivacaine with epinephrine 50 mL vials are on back order and the company estimates a release date of June 2021. The ... The 0.5% bupivacaine with epinephrine 30 mL preservative-free vials are on back order and the company estimates a release date ... The 0.25% bupivacaine with epinephrine 30 mL preservative-free vials are on back order and the company estimates a release date ...
O/B stands for Oxymorphone-Bupivacaine (drug combination). O/B is defined as Oxymorphone-Bupivacaine (drug combination) very ... S.v. "O/B." Retrieved June 13 2021 from https://www.acronymfinder.com/Oxymorphone_Bupivacaine-(drug-combination)-(O%2fB).html ... a href=https://www.acronymfinder.com/Oxymorphone_Bupivacaine-(drug-combination)-(O%2fB).html,O/B,/a,. ... 2021 https://www.acronymfinder.com/Oxymorphone_Bupivacaine-(drug-combination)-(O%2fB).html ...
Bupivacaine (an experimental pain-relieving medication). SABER™-Bupivac... ... Bupivacaine is designed to continuously deliver bupivacaine, a common local ane.... Trial of Extended Release Bupivacaine for ... medication). SABER™-Bupivacaine is designed to continuously deliver bupivacaine, a common local anesthetic, for a few days in ... Liposomal Bupivacaine vs. Bupivacaine Hydrochloride with Lidocaine During Midurethral Sling Placement: a Randomized Controlled ...
Great price on Bupivacaine 25mg/10ml (0.25%) inj ampoules. FREE delivery options available. Trusted service, convenient and ... Bupivacaine 25mg/10ml (0.25%) inj ampoules. Registered UK Online Pharmacy - Prescription item. To purchase this item you must ...
  • We have recommended treating bupivacaine-associated cardiac arrest by injecting a 1 mL/kg bolus of 20% lipid emulsion (such as Intralipid) and starting an infusion of 0.25 mL/kg/min for 10 min, while continuing basic life support ( 5 ). (lww.com)
  • The maximum cumulative safe dose for adults and children of a 0.25% solution of bupivacaine is 1.5 mg/kg. (who.int)
  • Pfizer has 0.25% bupivacaine with epinephrine 10 mL preservative-free vials on back order and the company estimates a release date of June 2021. (ashp.org)
  • This may be facilitated by using lower concentrations of bupivacaine, for example the 0.25% or 0.125% solutions that have been recommended for other neonatal regional anesthesia procedures, 3 or by limiting 0.5% bupivacaine to 0.25 mL per kg 2 or 1.5 to 2 mg per kg. (aafp.org)
  • Hospira, Inc. on July 12, 2013, initiated a voluntary nationwide recall to the user level for one lot of 0.25% Bupivacaine HCl Injection, USP (2.5 mg/mL), 30 mL Single-dose Vial (NDC 0409-1159-02). (asahq.org)
  • The particulate was identified as stainless steel ranging in size from 542 microns to 1700 microns in lot 18-136-DK (0.25% bupivacaine) and as iron oxide with an average size of 2000 microns in lot 23-338-DK (0.75% bupivacaine). (asahq.org)
  • Bupivacaine 0.25% and 0.5% solutions are used for the production of local anaesthesia by percutaneous infiltration, peripheral nerve block(s) and central neural block (caudal or epidural), that is, for specialist use in areas where prolonged anaesthesia is indicated. (medicines.org.uk)
  • Exposure to concentrations up to 0.25% of bupivacaine, 0.5% of ropivacaine, and 0.5% of mepivacaine did not reveal significant chondrotoxicity in flow cytometry. (ovid.com)
  • METHODS: In a randomized double-blind design, 60 adult American Society of Anesthesiologists class I or class II patients undergoing elective arthroscopic knee surgery under general anesthesia were randomized to 3 groups: all received 30 mL of 0.25% bupivacaine, plus either 1 mL of normal saline solution (group I), 1 mL (50 mug) of fentanyl (group II), or 1 mL (50 mg) of tramadol (group III). (druglib.com)
  • group Group B received fentanyl (100?g) with the local anaesthetic mixtures( 1% lignocaine, 0.25% bupivacaine). (banglajol.info)
  • Bupivacaine Hydrochloride is available in sterile isotonic solutions with and without epinephrine (as bitartrate) 1:200,000 for injection via local infiltration, peripheral nerve block, and caudal and lumbar epidural blocks. (nih.gov)
  • Solutions of Bupivacaine Hydrochloride may be autoclaved if they do not contain epinephrine. (nih.gov)
  • If you have an allergy to bupivacaine, epinephrine, or any other part of this drug. (mskcc.org)
  • However, we and others ( 3 ) believe the rapid return of normal rhythm and hemodynamics in both dogs and rats following massive bupivacaine overdose (twice the dose used in Mayr's study), indicates superior efficacy of lipid rescue for bupivacaine toxicity to drugs, such as epinephrine and vasopressin that are components of the generic ACLS protocol for cardiopulmonary arrest ( 4 ). (lww.com)
  • Perhaps Dr. Mayr will consider comparing combined epinephrine/vasopressin with lipid rescue in the porcine model of bupivacaine cardiac toxicity. (lww.com)
  • Fresenius Kabi has bupivacaine and epinephrine on shortage due to increased demand and manufacturing delays. (ashp.org)
  • Pfizer has bupivacaine with epinephrine on shortage due to manufacturing delays. (ashp.org)
  • Fore Pharma has released its new research, Bupivacaine / Epinephrine Sales, Price Analysis, & Sales Forecast - 2017. (reportlinker.com)
  • Find out the sales of Bupivacaine / Epinephrine worldwide and by countries in North America, Europe, Japan, BRIC, and Australia. (reportlinker.com)
  • Discover the growth trends of Bupivacaine / Epinephrine by countries, and also find out sales forecast until 2021. (reportlinker.com)
  • The research also provides Bupivacaine / Epinephrine unit price by countries. (reportlinker.com)
  • The sales and price data from this report is useful for analyzing Bupivacaine / Epinephrine sales trends, sales forecast for Bupivacaine / Epinephrine, brand planning, Bupivacaine / Epinephrine generics trends, product positioning, strategic forecasts, BD&L, competitive intelligence, pricing analysis, and price benchmarks. (reportlinker.com)
  • Patients were assigned to receive either 20 mL of 0.5% racemic bupivacaine or 20 mL of 0.5% levobupivacaine, both with 10 µg sufentanil and epinephrine 1:200,000. (scielo.br)
  • Randomized trial of intraoperative intercostal block with bupivacaine with epinephrine compared to lipossomal extended release bupivacaine. (bioportfolio.com)
  • Spinal analgesia during labor with low-dose bupivacaine, sufentanil, and epinephrine. (biomedsearch.com)
  • Bupivacaine is commercially available as a racemic mixture of R(+) and S(-) enantiomers and it was first used in spinal blocks in concentrations of 0.5%, 0.75%, and 1%, with or without epinephrine 1 . (scielo.br)
  • Concentrated bupivacaine is not recommended for epidural freezing. (wikipedia.org)
  • Bupivacaine is indicated for local infiltration, peripheral nerve block, sympathetic nerve block, and epidural and caudal blocks. (wikipedia.org)
  • Bupivacaine has caused several deaths when the epidural anaesthetic has been administered intravenously accidentally. (wikipedia.org)
  • Bupivacaine is given as an epidural injection into the spinal column to produce numbness during labor, surgery, or certain medical procedures. (cigna.com)
  • For an epidural, bupivacaine is given as an injection through a needle placed into an area of your middle or lower back near your spine. (cigna.com)
  • Bupivacaine-fentanyl is a narcotic analgesic combination medication used to treat pain, often through an epidural administration. (patientslikeme.com)
  • We conducted a retrospective study to determine whether bupivacaine or fentanyl is a better adjuvant to epidural morphine for postoperative analgesia using 108 patients. (springer.com)
  • In conclusion, fentanyl appears to be a better adjuvant to epidural morphine than bupivacaine. (springer.com)
  • This study aimed at comparing racemic bupivacaine and levobupivacaine in epidural anesthesia for elective cesarean section. (scielo.br)
  • Fifteen minutes after epidural anesthesia, 62.5% of levobupivacaine group patients experienced Bromage 2 or 3 motor block, whereas the same event was documented in 72.7% of bupivacaine group patients (p = 0.83). (scielo.br)
  • Levobupivacaine and bupivacaine were equally effective for epidural block in patients undergoing cesarean section. (scielo.br)
  • Currently, most common drug for obstetric epidural anesthesia is bupivacaine. (scielo.br)
  • A clinical comparison of compounded solution (2% xylocaine & 0.5% bupivacaine) with 0.5% bupivacaine in epidural analgesia. (thefreelibrary.com)
  • The commonly used drugs for epidural analgesia are 2% xylocaine and 0.5% bupivacaine. (thefreelibrary.com)
  • Epidural solutions containing combinations of bupivacaine hydrochloride and fentanyl citrate are commonly administered in the labor and delivery and postoperative settings for pain control. (ijpc.com)
  • For epidural anaesthesia, a test dose of 3 - 5ml of bupivacaine containing adrenaline should be administered, since an intravascular injection of adrenaline will be quickly recognised by an increase in heart rate. (medicines.org.uk)
  • The fixed-dose combination of bupivacaine with Type I collagen (brand name Xaracoll) is indicated for acute postsurgical analgesia (pain relief) for up to 24 hours in adults following open inguinal hernia repair. (wikipedia.org)
  • Bupivacaine (Posimir) is indicated in adults for administration into the subacromial space under direct arthroscopic visualization to produce post-surgical analgesia for up to 72 hours following arthroscopic subacromial decompression. (wikipedia.org)
  • XaraColl®, a collagen-based implant that delivers bupivacaine to the site of surgical trauma, is under development for postoperative analgesia. (dovepress.com)
  • The use of liposomal bupivacaine, compared with use of bupivacaine HCl, following gynecologic surgery decreased the need for narcotics and reduced the use of patient-controlled analgesia. (obgyn.net)
  • Still, the data pointed to a reduction in use of patient-controlled analgesia among those who were treated with liposomal bupivacaine (1.4% vs 8.3%, P=.05). (obgyn.net)
  • This was also found among women who underwent cytoreductive surgeries, with 4.1% of the women treated with liposomal bupivacaine using patient-controlled analgesia compared with 33.3% of women in the control group. (obgyn.net)
  • Conclusion: The present study demonstrates that addition of 20 mg nalbuphine to bupivacaine in supraclavicular brachial plexus block is associated with significant increase in the duration of both sensory and motor block and also prolong the duration of analgesia. (scirp.org)
  • 4. Stolik-Dollberg OC, Dollberg S. Bupivacaine versus lidocaine analgesia for neonatal circumcision. (aafp.org)
  • Liposomal bupivacaine was developed for injection at the surgical site with the potential for extended analgesia. (healio.com)
  • Multiple studies have reported successful results and improvement in postoperative analgesia with liposomal bupivacaine. (healio.com)
  • Bupivacaine is indicated for the production of local or regional anesthesia or analgesia for surgery, dental and oral surgery procedures, diagnostic and therapeutic procedures, and for obstetrical procedures. (asahq.org)
  • Does Continuous Wound Infusion of 0.2% Bupivacaine Provide Superior Analgesia Compared to Standard Opioid-based Therapy in Patients Following Axillary Clearance Surgery? (knowcancer.com)
  • It is intended to be administered during surgery, where it continuously releases therapeutic levels of bupivacaine in a controlled fashion, providing up to 72 hours of uninterrupted local analgesia. (fiercepharma.com)
  • Hower, despite incorporating more data in the analysis, we found little evidence that the need for conversion to general anaesthesia and supplemental analgesia differed between the hyperbaric or isobaric bupivacaine groups. (cochrane.org)
  • The duration of analgesia and comparative efficacy of liposomal bupivacaine and an elastomeric bupivacaine pump in a diverse surgical population were determined" Kenes et al (2015). (ivteam.com)
  • Bupivacaine analgesia in morphine tolerance reduced. (sid.ir)
  • The Objectives were to compare the mean period of analgesia for intrathecal Midazolam 0.5 ml plus bupivacaine and bupivacaine alone and to monitor the side effects of intrathecal Midazolam (0.5 ml) plus bupivacaine and bupivacaine alone. (alliedacademies.org)
  • Many authors have suggested the addition of 0.5 ml Midazolam to bupivacaine to extend the period of analgesia [ 1 , 2 , 3 ]. (alliedacademies.org)
  • So this study was carried out to study the effect of addition of 0.5 ml intrathecal Midazolam to bupivacaine in humans with the objectives to compare the mean period of analgesia for intrathecal Midazolam 0.5 ml plus bupivacaine and bupivacaine alone and to compare the side effects of intrathecal Midazolam (0.5 ml) plus bupivacaine and bupivacaine alone. (alliedacademies.org)
  • This prospective, randomized comparative study was conducted to compare the onset time of sensory block, onset time of motor block and time to achieve complete block, duration of analgesia adding fentanyl with bupivacaine-lignocaine mixtures in supraclavicular brachial plexus block. (banglajol.info)
  • Liposomal formulations of bupivacaine (brand name EXPAREL) have shown to be more effective in providing pain relief than plain solutions of bupivacaine. (wikipedia.org)
  • however, a new delivery system for bupivacaine ( Exparel , Pacira), in which injected liposomes release the drug slowly, relieves pain for 72 hours, he explained. (medscape.com)
  • November 12, 2018 -- The ADA has created a new Code on Dental Procedures and Nomenclature (CDT) for Exparel, a bupivacaine liposome injectable suspension from Pacira Pharmaceuticals . (drbicuspid.com)
  • EXPAREL is a sterile, non-pyrogenic white to off-white preservative-free aqueous suspension of multivesicular liposomes (DepoFoam ® drug delivery system) containing bupivacaine. (rxlist.com)
  • After injection of EXPAREL into soft tissue, bupivacaine is released from the multivesicular liposomes over a period of time. (rxlist.com)
  • Therefore, it is not possible to convert dosing from any other formulations of bupivacaine to EXPAREL. (rxlist.com)
  • This alert is being issued to inform health professionals about a potential medication safety issue with Exparel (bupivacaine liposome injectable suspension): wrong route of administration errors if the drug is confused with propofol. (ismp.org)
  • Ensure that directions for treatment of bupivacaine toxicity are readily available in all surgical areas where Exparel may be used. (ismp.org)
  • The investigators have therefore chosen liposomal bupivacaine (Exparel, Pacira Pharmaceuticals), which is an FDA approved product for local infiltration that has a longer duration of action (up to 72 hours) and a slower absorption into the systemic circulation, avoiding high plasma concentrations. (checkorphan.org)
  • The prospective randomized study was conducted to compare the analgesic efficacy of dilute concentration of bupivacaine and ropivacaine with fentanyl. (thefreedictionary.com)
  • What is Bupivacaine-Fentanyl? (patientslikeme.com)
  • No patients have reported taking Bupivacaine-Fentanyl. (patientslikeme.com)
  • There are no evaluations for Bupivacaine-Fentanyl. (patientslikeme.com)
  • Eighty patients were prospectively randomised to receive plain 1.5 ml levobupivacaine 0.5% (group levobupivacaine) or 1.5 ml plain bupivacaine 0.5% (group bupivacaine) in combination with fentanyl 0.3 ml (15 microg) for spinal anaesthesia. (biomedsearch.com)
  • Intrathecal hyperbaric or isobaric bupivacaine and ropivacaine with fentanyl for elective caesarean section. (biomedsearch.com)
  • METHODS: One hundred and three term parturients were randomly assigned to receive intrathecal 10 mg hyperbaric bupivacaine (Group Bh), 10 mg plain bupivacaine (Group Bp), 15 mg hyperbaric ropivacaine prepared with dextrose 30% (Group Rh) or 15 mg plain ropivacaine (Group Rp) coadministered with fentanyl 20 μg. (biomedsearch.com)
  • The aim of this study was to evaluate analgesic effects of Bupivacaine (marcaine), Bupivacaine plus midazolam, and Bupivacaine plus fentanyl in reducing pain after knee arthroscopic surgery. (magiran.com)
  • Group A, B and C received Bupivacaine (50 mg), Bupivacaine (50 mg) plus midazolam (50 μg/kg), and Bupivacaine (50 mg) plus fentanyl (3 μg/kg), respectively. (magiran.com)
  • The spinal regimen was 5 mg bupivacaine heavy 0,5% combined with 50 mcg fentanyl. (omicsonline.org)
  • Low dose spinal anesthesia using 5 mg of bupivacaine heavy 0,5% and adjuvant opioid fentanyl 50 mcg can be successfully used for the performance of CS delivery as regards to onset, adequacy, level, duration of the block and hemodynamic stability and good fetal outcome, with impressive cardiovascular stability. (omicsonline.org)
  • Evaluation of analgesic efficacy of intra-articular bupivacaine, bupivacaine plus fentanyl, and bupivacaine plus tramadol after arthroscopic knee surgery. (druglib.com)
  • PURPOSE: To compare the efficacy of intra-articular (IA) bupivacaine, bupivacaine-fentanyl, and bupivacaine-tramadol for relief of postoperative pain after arthroscopic knee surgery. (druglib.com)
  • CONCLUSIONS: On the primary outcome measure (VAS pain score), both bupivacaine with fentanyl and bupivacaine with tramadol were better than IA bupivacaine, and bupivacaine with fentanyl was better than that with tramadol. (druglib.com)
  • Thus IA bupivacaine-fentanyl appears to be the best combination for relief of postoperative pain in patients undergoing arthroscopic knee surgery, followed by IA bupivacaine-tramadol. (druglib.com)
  • Bupivacaine, marketed under the brand name Marcaine among others, is a medication used to decrease feeling in a specific area. (wikipedia.org)
  • We report a case of central nervous system toxicity associated with bupivacaine (Marcaine) dorsal penile block used to facilitate a circumcision. (aafp.org)
  • The US Food and Drug Administration (FDA) has alerted health care professionals that Hospira, Inc (Lake Forest, IL) has announced a voluntary nationwide recall to the user level for 1 lot of 0.5% Marcaine (bupivacaine HCl injection, USP), 30 mL, single-dose vial - preservative free (NDC 0409-1560-29), lot 33-545-DD. (asrs.org)
  • In the bupivacaine group, an intraoperative extended-release liposome injection of bupivacaine 266 mg was administered at the end of surgery. (medscape.com)
  • Recent clinical reports and animal research suggest that these cardiovascular changes are more likely to occur after unintended intravascular injection of bupivacaine. (nih.gov)
  • However, accidental intravascular injection of bupivacaine can produce severe arrhythmias and cardiac depression. (ahajournals.org)
  • Neurotoxicity of intraneural injection of bupivacaine liposome injectable suspension versus bupivacaine hydrochloride in a porcine model. (bioportfolio.com)
  • Risks of discontinuing breast feeding versus discontinuing bupivacaine should be discussed with the patient. (wikipedia.org)
  • Large Dose Bupivacaine 0.5% versus Small Dose in Elective Cesarean Section. (nih.gov)
  • Ayman M, Materazzi G, Bericotti M et al (2012) Bupivacaine 0.5% versus ropivacaine 0.75% wound infiltration to decrease postoperative pain in total thyroidectomy, a prospective controlled study. (springer.com)
  • Levobupivacaína versus bupivacaína en anestesia peridural para cesáreas. (scielo.br)
  • After 20 minutes, 66.7% of levobupivacaine group patients experienced Bromage 2 or 3 motor block versus 86.3% of bupivacaine group patients (p = 0.21). (scielo.br)
  • The aim of this study was to evaluate the effect of nalbuphine as an adjuvant to local anesthetics in peripheral nerve block, so we compare the effect of a combination of nalbuphine and bupivacaine versus bupivacaine alone in supraclavicular brachial plexus block for the patients undergoing elective upper limb surgeries. (scirp.org)
  • This study aims to compare the effectiveness of liposomal bupivacaine (LB) versus standard of practice local injection containing plain bupivacaine. (bioportfolio.com)
  • The investigators will be comparing pain scores and opioid use in patients receiving interscalene peripheral blocks with plain bupivacaine versus those receiving liposomal bupivacaine. (bioportfolio.com)
  • Effects of Bupivacaine Versus Bupivacaine Plus Dexamethasone-Soaked Nasal Packing After Endoscopic Nasal Surgery. (bioportfolio.com)
  • The aim of this randomized prospective study was to investigate the postoperative analgesic effectiveness of bupivacaine versus bupivacaine plus dexamethasone-soaked nasal packing in patients schedule. (bioportfolio.com)
  • Kenes, M.T., Leonard, M.C., Bauer, S.R. and Wyman, M.J. (2015) Liposomal bupivacaine versus continuous infusion bupivacaine via an elastomeric pump for the treatment of postoperative pain. (ivteam.com)
  • After surgical sperm retrieval, the wound will be injected with liposomal bupivacaine (266 mg) mixed with standard bupivacaine (bupivacaine hydrochloride 50mg) for post-operative pain relief. (clinicaltrials.gov)
  • Bupivacaine application is effective in decreasing postoperative pain and analgesic requirement during the hospital stay for patients with thyroidectomy. (springer.com)
  • The local anesthetic bupivacaine is a common analgesic adjuvant medication used in combination with opioids in intrathecal drug delivery systems (IDDSs). (bioportfolio.com)
  • Liposomal bupivacaine is an analgesic consisting of bupivacaine hydrochloride encapsulated within multiple, non-concentric lipid bi-layers offering a novel method of sustained release. (cochrane.org)
  • To assess the analgesic efficacy and adverse effects of liposomal bupivacaine infiltration peripheral nerve block for the management of postoperative pain. (cochrane.org)
  • 7-NI the nNOS inhibitor drug could reduce the tolerance to analgesic effect of morphine along bupivacaine in compare to morphine tolerance. (sid.ir)
  • Conclusion: The results showed that nNOS has a crucial role in reduction of analgesic effect of bupivacaine in morphine tolerance. (sid.ir)
  • A comparative study was carried out to evaluate the analgesic efficacy and side effects of intrathecal Midazolam along with 0.5% Bupivacaine in 80 ASA I and II patients, aged 16 - 60 years, undergoing surgeries below umbilicus, elective as well as emergency. (alliedacademies.org)
  • Liposomal Bupivacaine vs. Bupivacaine Hydrochloride with Lidocaine During Midurethral Sling Placement: a Randomized Controlled Trial. (bioportfolio.com)
  • The primary objective was to study the effects of liposomal bupivacaine (LB) compared to bupivacaine HCL with lidocaine on postoperative day 1 pain scores. (bioportfolio.com)
  • A local anesthetic that is chemically related to BUPIVACAINE but pharmacologically related to LIDOCAINE. (bioportfolio.com)
  • 4 In addition, lidocaine (Xylocaine) may offer a wider margin of safety than bupivacaine and may be the preferred agent in these cases. (aafp.org)
  • To test whether neurotoxic effects of a bupivacaine liposome injectable suspension differ from those of a standard formulation of bupivacaine hydrochloride (HCl) after intraneural injection into the s. (bioportfolio.com)
  • To determine the effective dose 50% (ED50) and the effective dose 95% (ED95) of intrathecal bupivacaine associated with opioids in the cesarean section of morbidly obese patients. (thefreedictionary.com)
  • sup][6],[11] However, to the best of our knowledge, few previous studies have determined the ideal dose of intrathecal bupivacaine when coadministered with sufentanil for cesarean delivery in severely preeclamptic parturients so far. (thefreedictionary.com)
  • Effect of Long-Term Intrathecal Bupivacaine Infusion on Blood Pressure. (bioportfolio.com)
  • OBJECTIVE: We aimed to investigate the efficacy of either plain or hyperbaric solutions of intrathecal bupivacaine and ropivacaine on maternal block characteristics, complications, side effects and neonatal parameters to find out which is superior in a single study. (biomedsearch.com)
  • A randomised, double-blind comparison of three different volumes of hypobaric intrathecal bupivacaine for orthopaedic surgery. (thefreelibrary.com)
  • We studied the effect of three different doses of oral clonidine on surgeries below umbilicus which were administered intrathecal bupivacaine. (omicsonline.org)
  • So this study compare efficacy of diclofenac and bupivacaine by measured the pain score and requirement of morphine injection. (clinicaltrials.gov)
  • Nady Hamid, MD, and colleagues recorded patient demographics, in-hospital numeric pain rating scale score obtained at 12-hour intervals, length of stay and total in-hospital morphine equivalents among 79 patients undergoing total shoulder arthroplasty and receiving either liposomal bupivacaine or interscalene block. (healio.com)
  • Effect of Morphine and Bupivacaine on. (scientific.net)
  • Therefore, the present study investigated the effect of morphine or bupivacaine on the secretion of nicotine-induced CAs from encapsulated chromaffin cells over a period of 180 min. (scientific.net)
  • The capsules were then pre-incubated with nicotine for 5 min prior to morphine or bupivacaine stimulation, and the quantity of CAs analyzed using a high performance liquid chromatography (HPLC) analysis system. (scientific.net)
  • The objective of this study was to evaluate the physical and chemical stability of morphine sulfate 5 mg/mL with bupivacaine hydrochloride 2.5 mg/mL in 0.9% sodium chloride injection and morphine sulfate 50 mg/mL with bupivacaine hydrochloride 25 mg/mL in sterile water for injection packaged in plastic syringes. (ijpc.com)
  • Test samples of morphine sulfate 5-mg/mL with bupivacaine hydrochloride 2.5-mg/mL and morphine sulfate 50-mg/mL with bupivacaine hydrochloride 25-mg/mL solutions were packaged as 20 mL of drug solution in 30-mL plastic syringes, sealed with plastic tip caps, and stored at 4°C and 23°C for 60 days. (ijpc.com)
  • The inclusion of the bupivacaine hydrochloride prevented the precipitation of morphine sulfate that occurs at a lower storage temperature. (ijpc.com)
  • However, morphine sulfate 50 mg/mL with bupivacaine hydrochloride 25 mg/mL exhibited a slight yellow discoloration after 7 days of storage at 23°C. (ijpc.com)
  • Little or no loss of morphine sulfate and bupivacaine hydrochloride occurred in any of the samples at any storage temperature throughout the study. (ijpc.com)
  • Morphine concentrations were found to be about 97% or greater, and bupivacaine hydrochloride concentrations were about 95% or greater throughout the study period under each storage condition. (ijpc.com)
  • Morphine sulfate solutions at concentrations ranging from 5 mg/mL to 50 mg/mL combined with bupivacaine hydrochloride 2.5 mg/mL to 25 mg/mL can be packaged in plastic syringes, stored, and shipped with little or no loss of drug. (ijpc.com)
  • Twenty minute after the last morphine injection at 5th day, bupivacaine 5 m g/kg was injected interathecally, and then formaline test was performed. (sid.ir)
  • In another series of experiments, 20 minutes after last morphine injection at 5th day, bupivacaine 5 m g/kg injected and then after 20 minutes, nNOS inhibitor (7-NI) 10 m g/?l was injected and after 60 minutes, formalin test was perfumed. (sid.ir)
  • Patients treated with extended-release bupivacaine also used less narcotic rescue medication, spent less time in the hospital, and had fewer falls than those treated with femoral nerve block. (medscape.com)
  • Dr. Emerson and his colleague, John Barrington, MD, from the Texas Center for Joint Replacement in Plano, presented results from 2 cohorts of patients treated with extended-release bupivacaine here at the American Academy of Orthopaedic Surgeons 2014 Annual Meeting. (medscape.com)
  • The extended-release bupivacaine cut the number of falls from 10 to 2 and saved $1246 per patient. (medscape.com)
  • 36 patients received extended-release bupivacaine and 36 received femoral nerve block. (medscape.com)
  • There were no adverse reactions to the extended-release bupivacaine, Dr. Emerson reported. (medscape.com)
  • Extended-release bupivacaine "has been an absolute game-changer as far as the control of pain," said Charles Lowry Barnes, MD, professor of orthopedics at the University of Arkansas in Little Rock. (medscape.com)
  • GB suppressed bupivacaine-induced mitochondrial depolarization and mitochondria complex I and III inhibition and increased cleaved caspase-3 and Htra2 expression, which was strongly indicative of activation of mitochondria-dependent apoptosis with concomitantly enhanced expressions of Grp78, caspase-12 mRNA, protein, and ER stress. (hindawi.com)
  • Mismar AA, Mahseeri MI, Al-Ghazawi MA et al (2017) Wound infiltration with bupivacaine 0.5% with or without adrenaline does not decrease pain after thyroidectomy. (springer.com)
  • Does Preincisional Infiltration with Bupivacaine Reduce Postoperative Pain in Laparoscopic Bariatric Surgery? (cun.es)
  • Therefore, we analyzed the influence of trocar site infiltration with bupivacaine on the management of postoperative pain in laparoscopic bariatric surgery. (cun.es)
  • Bupivacaine is contraindicated in patients with known hypersensitivity reactions to bupivacaine or amino-amide anesthetics. (wikipedia.org)
  • Each vial contains bupivacaine at a nominal concentration of 13.3 mg/mL. (rxlist.com)
  • The novel delivery system contains bupivacaine within a carrier molecule that allows gradual release over an extended period. (healio.com)
  • Each 1ml contains bupivacaine hydrochloride BP equivalent to 0.5% w/v anhydrous Bupivacaine Hydrochloride. (medicines.org.uk)
  • The spinal anesthesia in a cesarean section is still presenting a challenge to the anesthetist in the form of either severe hypotension from large bupivacaine dose or insufficient satisfactory anesthesia level conditions as a result of small bupivacaine dose. (nih.gov)
  • Large dose 15 mg of bupivacaine with the prolonged sitting position will lead to fewer incidences of hypotension and proper anesthesia block. (nih.gov)
  • Nanoscale Bupivacaine Formulations to Enhance the Duration and Safety of Intravenous Regional Anesthesia. (bioportfolio.com)
  • This study demonstrated that in patients undergoing shoulder arthroplasty, liposomal bupivacaine provided comparable pain control and opioid consumption compared to regional anesthesia without the added cost and risk of going to a regional anesthetic procedure," Hamid told Healio.com/Orthopedics . (healio.com)
  • Background Bupivacaine is a potent local anesthetic widely used for prolonged local and regional anesthesia. (ahajournals.org)
  • Although used clinically as a racemic mixture, S (−)-bupivacaine appears less toxic than the R (+)-enantiomer despite at least equal potency for local anesthesia. (ahajournals.org)
  • Hyperbaric bupivacaine (0.75% in dextrose) is used for spinal obstetric anesthesia. (bioportfolio.com)
  • To determine the dose of hyperbaric bupivacaine 0.5% required for unilateral spinal anesthesia during diagnostic knee arthroscopy. (dovepress.com)
  • However, 7.5 mg of hyperbaric bupivacaine 0.5% was the dose required for adequate unilateral spinal anesthesia. (dovepress.com)
  • and the choice of bupivacaine for regional anesthesia. (aafp.org)
  • Bupivacaine is a prescription medication used to prevent pain and induce spinal anesthesia. (rxwiki.com)
  • Bupivacaine injection should not be used in obstetrical paracervical block (local anesthetic injection around cervix) anesthesia. (rxwiki.com)
  • NEW ORLEANS - The extended-release formulation of the local anesthetic bupivacaine is just as effective as a femoral nerve block for relieving pain after total knee replacement surgery, new research shows. (medscape.com)
  • They will be assigned to either TAP block with the liposomal bupivacaine solution or to traditional preincisional local anesthetic with bupivacaine alone. (thefreedictionary.com)
  • Bupivacaine is an anesthetic (numbing medicine) that blocks nerve impulses in your body. (cigna.com)
  • Bupivacaine is used as a local (in only one area) anesthetic. (cigna.com)
  • Bupivacaine is also used as an anesthetic for dental procedures. (cigna.com)
  • The local anesthetic agent bupivacaine increases action potential duration in isolated frog atrial myocytes, and blocks two potassium conductances, IK and IK1. (nih.gov)
  • A local anesthetic with rapid onset and long action, similar to BUPIVACAINE. (bioportfolio.com)
  • We tested the neuroprotective efficacy of ginkgolide B (GB), an active component of Ginkgo biloba, against ROS-mediated neurotoxicity caused by the local anesthetic bupivacaine. (hindawi.com)
  • Local anesthetic bupivacaine is found in two different enantiomers: levobupivacaine - S (-) and dextrobupivacaine - R (+). Based on studies showing that S(-) enantiomers are less cardiotoxic, their use has been increasing in clinical practice. (scielo.br)
  • The study is a drug trial comparing the post-operative pain control provided by liposomal bupivacaine (a local anesthetic) against standard bupivacaine (a different formulation of the local anesthetic) for men undergoing testicular sperm extraction. (clinicaltrials.gov)
  • Investigation into spinal anesthetic failure with hyperbaric bupivacaine: the role of cold exposure on bupivacaine degradation. (bioportfolio.com)
  • Impaired autophagosome clearance contributes to local anesthetic bupivacaine-induced myotoxicity in mouse myoblasts. (sigmaaldrich.com)
  • 6 This case exemplifies the principle that relatively small volumes of bupivacaine may result in local anesthetic toxicity. (aafp.org)
  • Bupivacaine is used as a local or regional anesthetic for various procedures. (rxwiki.com)
  • The anesthetic action of S(-)-bupivacaine, R(+)-bupivacaine and ropivacaine was directly compared in vitro by studying their effects on action potential and the maximum value of dV/dt (dV/dt max) in crayfish giant axon. (nii.ac.jp)
  • Publications] Kanai Yuko, Katsuki Hiroshi and Takasaki Mayumi: 'Comparison of anesthetic effect of bupivacaine and ropivacaine. (nii.ac.jp)
  • Bupivacaine is an amino amide anesthetic that decreases current amplitude and inhibits whole cell K+ currents in Ca2+-activated (BK/SK) K+ channels and N-type voltage-gated (Kv1/shaker and Kv3 KCNA/KCNC) K+ channels. (lktlabs.com)
  • Results published in Orthopedics showed similar efficacy between injectable liposomal bupivacaine and an interscalene brachial plexus block among patients who underwent total shoulder arthroplasty. (healio.com)
  • Patients and Methods: Fifty-six patients under- going elective forearm and hand surgery under supraclavicular brachial plexus block were allocated randomly into one of two groups of 28 patients each to receive either 25 ml (0.5%) bupivacaine with 1 ml of NS or 25 ml (0.5%) bupivacaine with 1 ml (20 mg) nalbuphine. (scirp.org)
  • Dumlu EG, Tokaç M, Öcal H et al (2015) Local bupivacaine for postoperative pain management in thyroidectomized patients: a prospective and controlled clinical study. (springer.com)
  • Unsurprisingly, the researchers found that patients who received liposomal bupivacaine following complex cytoreductive surgery required significantly fewer doses of intravenous opioids during the first and second postoperative days than those whose pain was managed with bupivacaine HCl. (obgyn.net)
  • This prospective, randomized, clinical study was performed in 80 patients who were assigned to four groups to receive different doses of intrathecal hyperbaric bupivacaine (5 mg, 7.5 mg, 10 mg and 12.5 mg in Groups 1, 2, 3, and 4 respectively). (dovepress.com)
  • Unilateral sensory and motor block can be achieved with doses of 5 mg and 7.5 mg hyperbaric bupivacaine 0.5% with a stable hemodynamic state. (dovepress.com)
  • He received two 1-mL doses of 0.5% bupivacaine, spaced apart by two to three minutes. (aafp.org)
  • The primary objective of this randomised clinical study was to evaluate the frequency of unilateral block when different doses of hypobaric bupivacaine solution were used for single limb orthopaedic surgery. (thefreelibrary.com)
  • The proposed study aims to investigate the effect of three different doses of oral clonidine on subarachnoid block, anxiolysis, sedation, hemodynamic stability and their side effects, in patients undergoing surgeries below umbilicus in order to find out its optimum dose as a premedication agent with spinal anaesthesia Bupivacaine . (omicsonline.org)
  • Bupivacaine may be neurotoxic at high doses, activating p38 MAPK, increasing levels of ROS and WDR53, and inducing apoptosis in neuroblastoma cells. (lktlabs.com)
  • Hyperbaric bupivacaine is commercially available in its racemic form. (scielo.br)
  • Separation of racemic bupivacaine allows the production of the levorotatory and dextrorotatory enantiomers. (scielo.br)
  • Background : Levobupivacaine and ropivacaine are both single S(-)-enantiomers that have less cardiotoxic and convulsant effects than racemic bupivacaine. (nii.ac.jp)
  • Concentrations of bupivacaine greater than 0.5% are contraindicated for this purpose in view of reports of cardiac arrest and maternal death. (who.int)
  • SH-SY5Y cells were treated with different concentrations of bupivacaine alone or following preincubation with GB. (hindawi.com)
  • A serum bupivacaine concentration, obtained 2.5 hours after injection, was 0.76 mcg per mL, which is consistent with previous reports of bupivacaine toxicity 1 and higher than bupivacaine concentrations reported in older boys after circumcision. (aafp.org)
  • At concentrations lower than 40 microM (concentrations encountered in clinical situations), the low capacity, high affinity apparent site was predominant and S(-)-bupivacaine exhibited a higher free fraction than R(+)-bupivacaine. (aspetjournals.org)
  • Human articular chondrocytes were exposed to equal and equipotent concentrations of bupivacaine, ropivacaine, and mepivacaine for 1 hour. (ovid.com)
  • A "heavy" solution (0.75% bupivacaine in 8.25% glucose) will provide the muscular relaxation required for abdominal surgery. (who.int)
  • An expanded recall was issued on August 29, 2013 for one lot of 0.75% Bupivacaine HCl Injection, USP (7.5 mg/mL), 30 mL Single-dose Vial (NDC 0409-1165-02). (asahq.org)
  • a lipid infusion such as propofol increases the dose of bupivacaine required to induce cardiac arrest, and, therefore, this strategy has been suggested as a potential means to improve outcomes from such toxicity. (lww.com)
  • The higher potency of R (+)-bupivacaine to block the inactivated state of the cardiac Na + channel may explain its higher toxicity because of the large contribution of the inactivated-state block during the plateau phase of the cardiac action potential. (ahajournals.org)
  • Acute bupivacaine toxicity as a result of venous leakage under the tourniquet cuff during a Bier block. (aafp.org)
  • Additionally, bupivacaine can cause chondrolysis after continuous infusion into a joint space. (wikipedia.org)
  • Hospira, Inc., a provider of injectable drugs and infusion technologies located in Lake Forest, Ill., has issued a voluntary recall of one lot of Preservative-Free Bupivacaine HCl Injection due to possible contamination with iron oxide. (petmd.com)
  • CONCLUSION: No difference was found between patients who received liposomal bupivacaine compared with elastomeric continuous infusion bupivacaine from a traditional pump in 24- or 72-hour postoperative opioid utilization after adjustment for baseline differences. (ivteam.com)
  • An implantable formulation of bupivacaine (Xaracoll) was approved for medical use in the United States in August 2020. (wikipedia.org)
  • Liposomal bupivacaine (LB) is Food and Drug Administration-approved extended-release formulation of bupivacaine for interscalene peripheral nerve blocks. (medworm.com)
  • What are the possible side effects of bupivacaine? (cigna.com)
  • In the study, which included about 400 surgical patients, researchers compared the efficacy of liposomal bupivacaine and bupivacaine hydrochloride (HCl) for controlling postoperative pain after laparotomy for gynecological malignancies. (obgyn.net)
  • This study aimed to evaluate the effect of liposomal bupivacaine infiltration on total amount of opioid use, incidence of AEs and length of stay (LOS) after minimally invasive (MIS) sigmoid coloctomy. (bmj.com)
  • Bupivacaine is available as a generic medication. (wikipedia.org)
  • Bupivacaine may also be used for purposes not listed in this medication guide. (cigna.com)
  • This is a research study testing SABER™-Bupivacaine (an experimental pain-relieving medication). (bioportfolio.com)
  • This is a research study of SABER® -Bupivacaine, an experimental medication designed to relieve pain up to 3 days after surgery. (bioportfolio.com)
  • This is an extension to a previous research trial testing SABER™-Bupivacaine (an experimental pain-relieving medication). (bioportfolio.com)
  • Bupivacaine added to liposomal bupivacaine addressed the delayed onset of this medication and gave an accurately matched comparison with the ropivacaine cocktail. (healio.com)
  • In the case of bupivacaine, there are no specific foods that you must exclude from your diet when receiving this medication. (rxwiki.com)
  • Compared to other local anaesthetics, bupivacaine is markedly cardiotoxic. (wikipedia.org)
  • Bupivacaine is related chemically and pharmacologically to the aminoacyl local anesthetics. (nih.gov)
  • Chapman PJ (1987) Review: bupivacaine-a long-acting local anaesthetic. (springer.com)
  • Bupivacaine is a long-acting local anaesthetic. (who.int)
  • To compare effects of local and systemic administrations of dexamethasone and local bupivacaine on postoperative pain in patients who have had tonsillectomy. (bioportfolio.com)
  • Thus, mitochondrial and ER damage associated with ROS overproduction may act synergistically to evoke cell death in response to bupivacaine or other structurally related local anesthetics. (hindawi.com)
  • El anestésico local bupivacaína es encontrado en la forma de dos enantiómeros: levobupivacaína - S (-) y dextrobupivacaína - R (+). Basado en estudios que demuestran que la cardiotoxicidad es menor con el enantiómero S(-), fue difundido el uso de este agente en la práctica clínica. (scielo.br)
  • ANESTHETICS, Local: 50% enantiomeric excess bupivacaine. (scielo.br)
  • 9) So to know the effectiveness of compounding the local anaesthetics, we have in our study, used 2% xylocaine and 0.5% bupivacaine in a 1:1 ratio. (thefreelibrary.com)
  • Bupivacaine belongs to a group of drugs called local anesthetics. (rxwiki.com)
  • Currently many cancer patients receive general opioids or local anesthetics, such as bupivacaine. (scientific.net)
  • Bupivacaine is an amide local anaesthetic used in hyperbaric and isobaric forms. (cochrane.org)
  • Local myotoxicity from sustained release of bupivacaine from microparticles. (semanticscholar.org)
  • RATIONALE: Bupivacaine is a local anaesthetic prohibited in equine sports. (diva-portal.org)
  • In this study, we tried to solve this challenge by increasing the dose of bupivacaine to achieve a proper spinal level accompanied by prolonged sitting up to avoid hypotension. (nih.gov)
  • Conclusions Both the large level of pulse-dependent block and the failure of the pure inactivated-state block model indicate that bupivacaine interacts with the activated (or open) state of the cardiac sodium channel in addition to its block of the inactivated state. (ahajournals.org)
  • These data indicate that bupivacaine is not transported through the brain capillary wall, i.e., the blood-brain barrier, from the bovine albumin-bound pool, but bupivacaine is partially available for transfer from the circulating AAG-bound pool. (aspetjournals.org)
  • At the time of closure of surgical incision, 20ml of bupivacaine 0. (thefreedictionary.com)
  • Participants in this arm will have a single injection of liposomal bupivacaine admixed with standard bupivacaine (266mg liposomal bupivacaine mixed with 50mg bupivacaine hydrochloride) at the conclusion of their surgical sperm retrieval procedure. (clinicaltrials.gov)
  • Participants in this arm will have a single injection of standard bupivacaine (100mg bupivacaine hydrochloride) at the conclusion of their surgical sperm retrieval procedure. (clinicaltrials.gov)
  • Randomised, double- blind , placebo - or active-controlled clinical trials of a single dose of liposomal bupivacaine administered as a peripheral nerve block in adults aged 18 years or over undergoing elective surgery at any surgical site. (cochrane.org)
  • XARACOLL is Innocoll's late-stage surgically implantable and bioresorbable collagen matrix developed to provide sustained postsurgical pain relief through controlled delivery of bupivacaine at the surgical site. (globenewswire.com)
  • XARACOLL® is a surgically implantable and bioresorbable bupivacaine-collagen matrix that utilizes our CollaRx® proprietary collagen-based delivery technology and is being developed to provide sustained postsurgical pain relief directly into the surgical site. (globenewswire.com)
  • CUPERTINO, Calif. , Feb. 9, 2011 /PRNewswire/ -- DURECT Corporation (Nasdaq: DRRX) announced today results from a European Phase IIb shoulder clinical trial conducted by Nycomed of POSIDUR™ (also known as SABER™-bupivacaine or Optesia™ in the E.U.), a proprietary product under development for the treatment of post-surgical pain, and the amendment of the Company's collaboration agreement with Nycomed. (fiercepharma.com)
  • Patients in the intervention group received 266mg of liposomal bupivacaine in the surgical incision by a single surgeon and were matched to controls for age, gender, BMI, procedure and extraction site. (bmj.com)
  • The aim of this randomised, double-blind, placebo-controlled trial was to evaluate the effectiveness of intraperitoneal instillation of bupivacaine following laparoscopy and dye test. (wiley.com)
  • This Cochrane Review summarizes the best available evidence for the effectiveness and safety of the denser form of bupivacaine compared to the isobaric form when spinal anaesthesia (injection of medications into the lower back) is used for delivery of a baby by caesarean section. (cochrane.org)
  • Its actions are more intense and its effects more prolonged than those of procaine but its duration of action is shorter than that of bupivacaine or prilocaine. (bioportfolio.com)
  • 0.4% hyperbaric 50% enantiomeric excess bupivacaine (S75:R25) with D5W provided fast onset of the blockade and the level of sensitive and motor blockades as well as the duration of the blockade were dose-dependent. (scielo.br)
  • Xylocaine produces good results but its duration of action is short whereas with bupivacaine, through it has a longer duration of action it takes longer time to start acting. (thefreelibrary.com)
  • For most indications, the duration of anaesthesia with bupivacaine solutions is such that a single dose is sufficient. (medicines.org.uk)
  • Different formulations of bupivacaine are not bioequivalent even if the milligram strength is the same. (rxlist.com)
  • see Non-Interchangeability with Other Formulations of Bupivacaine ]. (rxlist.com)
  • Bupivacaine without adrenaline may also be used for intradural spinal anaesthesia. (medicines.org.uk)
  • We included all randomized controlled trials (RCTs) involving parturients undergoing spinal anaesthesia for elective caesarean section that compared the use of hyperbaric with isobaric bupivacaine. (cochrane.org)
  • Preoperative oral clonidine 4 μg kg-1 appears to be the optimum dose for optimization of spinal anaesthesia with bupivacaine as it prolongs the sensory block maximally with minimal side effects. (omicsonline.org)
  • These results implicate bupivacaine-induced ROS-dependent mitochondria, ER dysfunction, and apoptosis, which can be attenuated by GB through its antioxidant property. (hindawi.com)
  • For example, bupivacaine may inhibit mitochondrial respiratory complexes I and III, leading to decreased ATP production, collapse of the mitochondrial membrane potential (Δ ψ m), overproduction of reactive oxygen species (ROS), and ultimately liberation of cytochrome c and activation of the caspase-3-dependent apoptosis pathway [ 10 - 12 ]. (hindawi.com)
  • DRG was prepared from adult C57BL/6 mice and incubated with 10 mM bupivacaine in vitro to induce apoptosis. (ovid.com)
  • SiRNA-mediated TNF-α or TNF-R1 inhibition, but not TNF-R2 inhibition, rescued bupivacaine-induced DRG apoptosis. (ovid.com)
  • In other cellular models, bupivacaine induces depolarization of the mitochondrial membrane potential, resulting in apoptosis. (lktlabs.com)
  • Bupivacaine-induced apoptosis independently of WDR35 expression in mouse neuroblastoma Neuro2a cells. (lktlabs.com)
  • Bupivacaine induces apoptosis via mitochondria and p38 MAPK dependent pathways. (lktlabs.com)
  • One group will receive liposomal bupivacaine plus bupivacaine and the other will receive bupivacaine alone. (bioportfolio.com)
  • We conducted a prospective double-blind randomized study assessing bupivacaine end-of-surgery wound infiltration for pain relief in thyroid surgery. (springer.com)
  • patients treated with femoral nerve block used twice as much as those treated with bupivacaine. (medscape.com)
  • However, elderly patients are more likely to have low blood pressure or kidney problems, which may require caution and an adjustment in the dose for patients receiving bupivacaine injection. (mayoclinic.org)
  • We included 53 patients in this study whom were randomly divided into two groups, namely Group B and Group C. In Group B (25 patients), each patient received 3 mL of bupivacaine and left 5 min sitting up, whereas in Group C (28 patients), each patient received 2.5 mL of bupivacaine and was asked to lie supine immediately. (nih.gov)
  • High blood levels of bupivacaine must be avoided in patients with hepatic impairment. (who.int)
  • The objective of this study was to compare the block durations and haemodynamic effects associated with intrathecal levobupivacaine or bupivacaine in elderly patients undergoing transurethral prostate surgery. (biomedsearch.com)
  • Participated in this study 47 patients being 24 in the levobupivacaine group and 23 in the bupivacaine group. (scielo.br)
  • Most common complication was hypotension, detected in 16 (66.7%) levobupivacaine group patients and in 10 (43.5%) bupivacaine group patients (p = 0.11). (scielo.br)
  • Using liposomal bupivacaine to control pain in patients after gynecological surgery reduced the amount of narcotics needed and may lead to faster recovery times, a recent study found. (obgyn.net)
  • During the first day following surgery, 21.5% of the patients treated with liposomal bupivacaine required opioids, while 46.9% of patients who received bupivacaine HCI were given opioids to control pain. (obgyn.net)
  • By day two, just 7.4% of patients treated with liposomal bupivacaine were given opioids compared with 27.2% in the other group. (obgyn.net)
  • In this study, 107 patients were randomly assigned to one of three treatment groups prior to undergoing elective arthroscopic shoulder surgery: POSIDUR at a dose of 5 mL, an active comparator (commercially available bupivacaine HCI solution) or SABER-Placebo (SABER vehicle without drug). (fiercepharma.com)
  • RESULTS: Sixty-seven liposomal bupivacaine and 262 elastomeric bupivacaine pump patients were included. (ivteam.com)
  • Conclusion When added to an aggressive ERP, liposomal bupivacaine does not decrease the amount of total opioid consumption, the incidence of AEs or the LOS in patients undergoing MIS sigmoid resection. (bmj.com)
  • Among patients undergoing shoulder arthroplasty, liposomal bupivacaine was shown to provide better pain relief at 19 to 21 weeks post-surgery with fewer complications compared with continuous interscalene nerve block, according to research published in the Journal of Shoulder & Elbow Surgery . (clinicalpainadvisor.com)
  • In this prospective clinical trial, 70 patients undergoing shoulder arthroplasty were randomly assigned to receive continuous interscalene nerve block (n=36) or liposomal bupivacaine (n=34) with a single bolus interscalene block. (clinicalpainadvisor.com)