Niacin: A water-soluble vitamin of the B complex occurring in various animal and plant tissues. It is required by the body for the formation of coenzymes NAD and NADP. It has PELLAGRA-curative, vasodilating, and antilipemic properties.Simvastatin: A derivative of LOVASTATIN and potent competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HYDROXYMETHYLGLUTARYL COA REDUCTASES), which is the rate-limiting enzyme in cholesterol biosynthesis. It may also interfere with steroid hormone production. Due to the induction of hepatic LDL RECEPTORS, it increases breakdown of LDL CHOLESTEROL.Hydroxymethylglutaryl-CoA Reductase Inhibitors: Compounds that inhibit HMG-CoA reductases. They have been shown to directly lower cholesterol synthesis.Flushing: A transient reddening of the face that may be due to fever, certain drugs, exertion, stress, or a disease process.Hypolipidemic Agents: Substances that lower the levels of certain LIPIDS in the BLOOD. They are used to treat HYPERLIPIDEMIAS.Pellagra: A disease due to deficiency of NIACIN, a B-complex vitamin, or its precursor TRYPTOPHAN. It is characterized by scaly DERMATITIS which is often associated with DIARRHEA and DEMENTIA (the three D's).Anticholesteremic Agents: Substances used to lower plasma CHOLESTEROL levels.AzetidinesLovastatin: A fungal metabolite isolated from cultures of Aspergillus terreus. The compound is a potent anticholesteremic agent. It inhibits 3-hydroxy-3-methylglutaryl coenzyme A reductase (HYDROXYMETHYLGLUTARYL COA REDUCTASES), which is the rate-limiting enzyme in cholesterol biosynthesis. It also stimulates the production of low-density lipoprotein receptors in the liver.Nicotinic Acids: 2-, 3-, or 4-Pyridinecarboxylic acids. Pyridine derivatives substituted with a carboxy group at the 2-, 3-, or 4-position. The 3-carboxy derivative (NIACIN) is active as a vitamin.Hypercholesterolemia: A condition with abnormally high levels of CHOLESTEROL in the blood. It is defined as a cholesterol value exceeding the 95th percentile for the population.Heptanoic Acids: 7-carbon saturated monocarboxylic acids.Delayed-Action Preparations: Dosage forms of a drug that act over a period of time by controlled-release processes or technology.Niacinamide: An important compound functioning as a component of the coenzyme NAD. Its primary significance is in the prevention and/or cure of blacktongue and PELLAGRA. Most animals cannot manufacture this compound in amounts sufficient to prevent nutritional deficiency and it therefore must be supplemented through dietary intake.Cholesterol, LDL: Cholesterol which is contained in or bound to low density lipoproteins (LDL), including CHOLESTEROL ESTERS and free cholesterol.Vitamin B Complex: A group of water-soluble vitamins, some of which are COENZYMES.Pravastatin: An antilipemic fungal metabolite isolated from cultures of Nocardia autotrophica. It acts as a competitive inhibitor of HMG CoA reductase (HYDROXYMETHYLGLUTARYL COA REDUCTASES).Mevalonic AcidPyrroles: Azoles of one NITROGEN and two double bonds that have aromatic chemical properties.Cholesterol: The principal sterol of all higher animals, distributed in body tissues, especially the brain and spinal cord, and in animal fats and oils.Vitamin B Deficiency: A condition due to deficiency in any member of the VITAMIN B COMPLEX. These B vitamins are water-soluble and must be obtained from the diet because they are easily lost in the urine. Unlike the lipid-soluble vitamins, they cannot be stored in the body fat.Dyslipidemias: Abnormalities in the serum levels of LIPIDS, including overproduction or deficiency. Abnormal serum lipid profiles may include high total CHOLESTEROL, high TRIGLYCERIDES, low HIGH DENSITY LIPOPROTEIN CHOLESTEROL, and elevated LOW DENSITY LIPOPROTEIN CHOLESTEROL.Drug Therapy, Combination: Therapy with two or more separate preparations given for a combined effect.FluorobenzenesLipids: A generic term for fats and lipoids, the alcohol-ether-soluble constituents of protoplasm, which are insoluble in water. They comprise the fats, fatty oils, essential oils, waxes, phospholipids, glycolipids, sulfolipids, aminolipids, chromolipids (lipochromes), and fatty acids. (Grant & Hackh's Chemical Dictionary, 5th ed)Colestipol: Highly crosslinked and insoluble basic anion exchange resin used as anticholesteremic. It may also may reduce triglyceride levels.Cholesterol, HDL: Cholesterol which is contained in or bound to high-density lipoproteins (HDL), including CHOLESTEROL ESTERS and free cholesterol.Dose-Response Relationship, Drug: The relationship between the dose of an administered drug and the response of the organism to the drug.Polyisoprenyl Phosphates: Phosphoric or pyrophosphoric acid esters of polyisoprenoids.Double-Blind Method: A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment.Tablets: Solid dosage forms, of varying weight, size, and shape, which may be molded or compressed, and which contain a medicinal substance in pure or diluted form. (Dorland, 28th ed)Chemistry, Pharmaceutical: Chemistry dealing with the composition and preparation of agents having PHARMACOLOGIC ACTIONS or diagnostic use.Tablets, Enteric-Coated: Tablets coated with material that delays release of the medication until after they leave the stomach. (Dorland, 28th ed)PropylaminesKinetics: The rate dynamics in chemical or physical systems.Secondary Prevention: The prevention of recurrences or exacerbations of a disease or complications of its therapy.Primary Prevention: Specific practices for the prevention of disease or mental disorders in susceptible individuals or populations. These include HEALTH PROMOTION, including mental health; protective procedures, such as COMMUNICABLE DISEASE CONTROL; and monitoring and regulation of ENVIRONMENTAL POLLUTANTS. Primary prevention is to be distinguished from SECONDARY PREVENTION and TERTIARY PREVENTION.Pharmacies: Facilities for the preparation and dispensing of drugs.Pharmaceutical Services: Total pharmaceutical services provided by qualified PHARMACISTS. In addition to the preparation and distribution of medical products, they may include consultative services provided to agencies and institutions which do not have a qualified pharmacist.Licensure, Pharmacy: The granting of a license to practice pharmacy.Contraceptives, Oral: Compounds, usually hormonal, taken orally in order to block ovulation and prevent the occurrence of pregnancy. The hormones are generally estrogen or progesterone or both.Disease Management: A broad approach to appropriate coordination of the entire disease treatment process that often involves shifting away from more expensive inpatient and acute care to areas such as preventive medicine, patient counseling and education, and outpatient care. This concept includes implications of appropriate versus inappropriate therapy on the overall cost and clinical outcome of a particular disease. (From Hosp Pharm 1995 Jul;30(7):596)Self Care: Performance of activities or tasks traditionally performed by professional health care providers. The concept includes care of oneself or one's family and friends.Specialization: An occupation limited in scope to a subsection of a broader field.Suppositories: Medicated dosage forms that are designed to be inserted into the rectal, vaginal, or urethral orifice of the body for absorption. Generally, the active ingredients are packaged in dosage forms containing fatty bases such as cocoa butter, hydrogenated oil, or glycerogelatin that are solid at room temperature but melt or dissolve at body temperature.Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.Uterus: The hollow thick-walled muscular organ in the female PELVIS. It consists of the fundus (the body) which is the site of EMBRYO IMPLANTATION and FETAL DEVELOPMENT. Beyond the isthmus at the perineal end of fundus, is CERVIX UTERI (the neck) opening into VAGINA. Beyond the isthmi at the upper abdominal end of fundus, are the FALLOPIAN TUBES.Pregnancy Outcome: Results of conception and ensuing pregnancy, including LIVE BIRTH; STILLBIRTH; SPONTANEOUS ABORTION; INDUCED ABORTION. The outcome may follow natural or artificial insemination or any of the various ASSISTED REPRODUCTIVE TECHNIQUES, such as EMBRYO TRANSFER or FERTILIZATION IN VITRO.Pregnancy Complications: Conditions or pathological processes associated with pregnancy. They can occur during or after pregnancy, and range from minor discomforts to serious diseases that require medical interventions. They include diseases in pregnant females, and pregnancies in females with diseases.Pregnancy, Animal: The process of bearing developing young (EMBRYOS or FETUSES) in utero in non-human mammals, beginning from FERTILIZATION to BIRTH.Chylomicron Remnants: Metabolic products of chylomicron particles in which TRIGLYCERIDES have been selectively removed by the LIPOPROTEIN LIPASE. These remnants carry dietary lipids in the blood and are cholesterol-rich. Their interactions with MACROPHAGES; ENDOTHELIAL CELLS; and SMOOTH MUSCLE CELLS in the artery wall can lead to ATHEROSCLEROSIS.Lipoproteins, HDL: A class of lipoproteins of small size (4-13 nm) and dense (greater than 1.063 g/ml) particles. HDL lipoproteins, synthesized in the liver without a lipid core, accumulate cholesterol esters from peripheral tissues and transport them to the liver for re-utilization or elimination from the body (the reverse cholesterol transport). Their major protein component is APOLIPOPROTEIN A-I. HDL also shuttle APOLIPOPROTEINS C and APOLIPOPROTEINS E to and from triglyceride-rich lipoproteins during their catabolism. HDL plasma level has been inversely correlated with the risk of cardiovascular diseases.Chylomicrons: A class of lipoproteins that carry dietary CHOLESTEROL and TRIGLYCERIDES from the SMALL INTESTINE to the tissues. Their density (0.93-1.006 g/ml) is the same as that of VERY-LOW-DENSITY LIPOPROTEINS.
Simvastatin: No tumorigenic effect was seen in a 72-week carcinogenicity study using mice at the low dose levels. However, at ... niacin, digoxin, coumarin anticoagulants, and colchicine. "FDA Approves Juvisync, Combination of Sitagliptin and Simvastatin". ... Simvastatin/sitagliptin (brand name Juvisync) is a fixed-dose combination drug consisting of sitagliptin and simvastatin. ... By creating a combined-dosage form of simvastatin and sitagliptin, Merck was able to increase their sales of simvastatin while ...
Niacin has HDL raising effects (by 10-30%) and showed clinical trial benefit in the Coronary Drug Project and is commonly used ... The first of the large secondary prevention comparative statin/placebo treatment trials was the Scandinavian Simvastatin ... HDL in people with unstable angina produced fairly dramatic reduction in measured coronary plaque volume in only six weeks vs. ... Combinations of statins, niacin and intestinal cholesterol absorption-inhibiting supplements (ezetimibe and others, and to a ...
The time to reach steady state is often longer than 2 weeks.[41][42][43][44] ... Niacin. *Nicotinamide (niacinamide). *Nonbenzodiazepines (e.g., β-carbolines (e.g., abecarnil), cyclopyrrolones (e.g., ... found that early antiepileptic treatment with either phenytoin or phenobarbital reduced the risk of seizure in the first week ...
ezetimibe/simvastatin 10/20mg tablet. Treatment time will be ~24 weeks.. Drug: Comparator: Placebo to Niacin (ER) Niacin (ER) ( ... niacin (ER). Drug: Comparator: ezetimibe/simvastatin and niacin (ER) ezetimibe/simvastatin 10/20mg tablet + niacin (ER) tablet ... niacin (ER). Drug: Comparator: ezetimibe/simvastatin + niacin (ER) ezetimibe/simvastatin 10/20mg tablet + niacin (ER) tablet, ... ezetimibe/simvastatin (Pbo) tablet. Treatment time will be ~24 weeks.. Drug: Comparator: niacin (ER) tablet niacin (ER) tablet ...
Percent Change in Low-density Lipoprotein Cholesterol (LDL-C) From Baseline to Week 12 [ Time Frame: From baseline to Week 12 ] ... Niacin Extended-release Plus Simvastatin. Up to 2000 mg of niacin extended-release plus 40 mg simvastatin once daily at bedtime ... Niacin Extended-release Plus Simvastatin. Up to 2000 mg of niacin extended-release plus 40 mg simvastatin once daily at bedtime ... An Open-Label Study to Compare the Lipid Effects of Niacin ER and Simvastatin (NS) to Atorvastatin in Subjects With ...
Get up-to-date information on Niacin and Simvastatin side effects, uses, dosage, overdose, pregnancy, alcohol and more. Learn ... The dose of niacin extended-release should not be increased by more than 500 mg daily every 4 weeks ... Niacin and simvastatin is a single product containing 2 medications: niacin and simvastatin. The niacin component is a B- ... Niacin and simvastatin falls into category X. It has been shown that women taking niacin and simvastatin during pregnancy may ...
... niacin, and antioxidants, and 3% in the simvastatin plus niacin group. Only the simvastatin plus niacin group had a ... The patch is changed once a week for three weeks. The patch-free fourth week allows for a menstrual period. The small (less ... simvastatin plus niacin, antioxidants alone, simvastatin and niacin plus antioxidants, or placebo. The antioxidant therapy was ... Simvastatin and Niacin, But Not Antioxidants, Reduce Risk of Coronary Heart Disease. High levels of low-density lipoprotein ( ...
Brown bg, zhao xq, chait a. Simvastatin and niacin, antioxidant vitamins, or iron supplements. Many renal transplant ambulatory ... Unit kg hour iv oral every to weeks after starting lenalidomide because cd positive stem cell support. Carbidopa does not ... weeks gestation or more, regardless of gender with in viagra rachael ray woemens pn admixtures. Siller matula jm, huber k, ...
... a combination of niacin, laropiprant, and simvastatin -- was put on hold in July. ... The phase 3 study for experimental combination diabetes/cholesterol drug MK-0431E was halted this week for "business reasons." ...
The impact of niacin-induced flushing during the first week of therapy in a real world setting. J. Am. Coll. Cardiol. 51, A255 ... Niacin reduces levels of LDL-C and triglycerides and is the most effective agent for increasing HDL-C levels [11]. Niacin at ... Although titration to simvastatin 40 mg would appear a logical option for patients not at LDL-C goal with simvastatin 20 mg, in ... Cost-effectiveness of extended-release niacin/laropiprant added to a stable simvastatin dose in secondary prevention patients ...
A statin plus extended-release niacin blended into a single investigational pill sent HDLs up and LDLs down in moderate- to ... In the 24-week trial of the simvastatin (Zocor)-niacin (Niaspan) compound, patients randomized to the therapy improved LDL ... Patients in the 1,000 mg niacin/20 mg simvastatin group increased HDL by 18% and those in the 2,000 mg niacin/20 mg simvastatin ... that compared 1,000 mg of niacin/40 mg of simvastatin or 2,000 mg of niacin/40 mg of simvastatin to 80 mg of simvastatin. All ...
ER niacin 1000 mg combined with simvastatin 20 mg reduced LDL-C by 6%, non-HDL-C by 7%, and triglycerides by 13%, and raised ... ER niacin-simvastatin is reasonably well tolerated, with a ... ER niacin combined with simvastatin provides an additional ... The 2000 mg dose combined with simvastatin 20 to 40 mg raised reduced LDL-C by 7% to 24%, non-HDL-C by 16% to 28%, and ... triglycerides by 23% to 34%, and increased HDL-C by 18% to 22% compared to similar dose simvastatin therapy. While ...
Impax said it had filed an approval application with the Food and Drug Administration for niacin and simvastatin extended- ... Weekend Update Weekly wrap-up of the weeks top stories Digital Edition Digital version of our latest print issue sent to your ...
... demonstrated that combination ezetimibe/simvastatin + extended-release niacin (E/S+N) is an effective therapeutic option for ... extended-release niacin to 2g or ezetimibe/simvastatin 10/20mg for 64 weeks, or extended-release niacin to 2g for 24 weeks ... compared with extended-release niacin and ezetimibe/simvastatin at 24 weeks and ezetimibe/simvastatin at 64 weeks. Attainment ... followed by then ezetimibe/simvastatin 10/20mg + extended-release niacin to 2g or ezetimibe/simvastatin 10/20mg for 40 weeks ...
... the effects were less evident than with simvastatin and niacin. Simvastatin/niacin produced the best results; simvastatin plus ... along with slow-release niacin, given at twice-daily doses ranging from 250 mg to 1000 mg for four weeks. They contrasted that ... All of these parameters improved with the simvastatin and niacin therapy, which was much more effective than simvastatin alone ... Simvastatin plus Niacin: the Best Results. The authors of this study conclude that contrary to the hypothesis that antioxidants ...
Highlights this week included: India firm on NO to data exclusivity (SiNApSE) (Generic Pharmaceuticals and IP) (Spicy IP) ( ... Simcor (Niacin, Simvastatin) - US: Abbott files patent infringement complaint against Watson following Para IV certification ... Pharma & Biotech Global Week in Review 6 April 2011 from IP Think Tank. Posted on April 6, 2011 By Duncan ... Highlights this week included:. India firm on NO to data exclusivity (SiNApSE) (Generic Pharmaceuticals and IP) (Spicy IP) ( ...
Highlights this week included: Australia: Surprise! New pharmaceutical compulsory licenses proposed for patented medicines ( ... Simcor (Niacin/Simvastatin) - US: Abbott files patent infringement complaint against Teva in response to Para IV certification ... Pharma & Biotech Global Week in Review 30 March 2011 from IP Think Tank. Posted on March 30, 2011 By Duncan ... EU: In the ECJ this week: Case C-195/09 Synthon v Merz Pharma and Case C-427/09 Generics (UK) v Synaptech (The SPC Blog) ...
... trusted information on whether Niacin can cause or treat Pregnancy: Dr. Saghafi on niaspan and pregnancy: Progesterone ... simvastatin and niacin) is made up of two meds; Simvastatin which mostly lowers LDL (bad) cholesterol, and Niacin which lowers ... My wife is week 4 pregancy and doctor prescribed miprogen and folvite (folic acid). So these are helpful for our baby? ... The most likely side effects of Simvastatin are an inflammed liver and muscle aches, and with Niacin an inflammed liver as well ...
Likewise Simcor is simvastatin and niacin. Vytorin is simvastatin and ezetimibe. Caudet is atorvastin and amoldipine. High ... Typically your enzymes will be tested a few (6-12) weeks into your statin treatment. And perhaps even before you begin ... niacin *fibrates *cholesterol inhibitors *bile acid sequesters In fact some statin manufactures combine other medications with ... For example… Advicor is a combination of lovastatin and niacin. ...
The 24-week clinical trial compared simvastatin alone with a combination of drugs niacin and simvastatin in 600 patients with ...
Niacins Role In Maintaining Good Cholesterol - Science Daily, 6/5/08. * Combination Niacin-Laropiprant Plus Simvastatin ... High sensitivity C-reactive protein decreased by 20% in the group treated with niacin for 52 weeks (p = 0.013). Niacin ... Comparison of the Safety and Efficacy of a Combination Tablet of Niacin Extended Release and Simvastatin vs Simvastatin ... on fasting glucose levels after 52 weeks of treatment - See niacin at Amazon.com. or niacin at Amazon.com. . ...
Patient Concerns and Latest Treatments and Simvastatin Reports and Side Effects. ... Feeling DIABETES MELLITUS while using Simvastatin? DIABETES MELLITUS Causes, ... I began taking 40mg dose of Zocor inNovember of 2009 three days a week. Took for 6 months. Had blood work done in March. ... I also take some vitamin pills that have 1000% niacin(for building good HDL) and Niac ...
Niacin) drug information & product resources from MPR including dosage information, educational materials, & patient assistance ... 16yrs: initially 500mg once daily for 4 weeks, then 1g once daily for weeks 5-8. May increase by up to 500mg every 4 weeks to ... The addition of Niaspan did not reduce cardiovascular morbidity or mortality among patients treated with simvastatin in a ... Do not substitute for equivalent doses of immediate-release or sustained-release niacin (hepatotoxicity may occur). History of ...
Kos also has a fixed-dose formulation combining niacin with simvastatin, Simcor, in late-stage development. This candidate is ... Last week, Merck offered a more than 100% premium when it offered to acquire Sirna Therapeutics for $1.1 billion. ... Kos is best known for its Niaspan (niacin) and Advicor (niacin plus lovastatin) products, both of which are recognised as being ...
Study Flashcards On Week 2: Pharmacology II at Cram.com. Quickly memorize the terms, phrases and much more. Cram.com makes it ... Which increases HDL most: simvastatin, niacin, or gemfibrozil? Niacin. Which decreases triglyceride level most: colestipol, ... ":"Week 2: Pharmacology II","payreferer_url":"\/flashcards\/copy\/week-2-pharmacology-ii-242847","isGuest":true,"ga_id":"UA- ...
simvastatin 0.64 0.89 0.89 0.83 Niacin extended-release Þ. 2 g single dose. 20 mg single dose. simvastatin acid simvastatin 1.6 ... The dosage of simvastatin (once daily in the evening) was 10 mg for the first 8 weeks, 20 mg for the second 8 weeks, and 40 mg ... simvastatin acid simvastatin simvastatin acid simvastatin 7.3 10.3 8.5 10.6 9.2 9.4 9.5 11.4 ... simvastatin acid simvastatin 1.7 2 1.6 2 Lomitapide. 10 mg QD for 7 days. 20 mg single dose. simvastatin acid simvastatin 1.4 ...
Comparison of the Safety and Efficacy of a Combination Tablet of Niacin Extended Release and Simvastatin vs Simvastatin ... plus simvastatin 20 mg/day (N = 29) for a total of 12 weeks. Lp(a) was significantly reduced in the L-carnitine/simvastatin ... FDA approves combination niacin and simvastatin - theheart.org, 2/19/08 - The US Food and Drug Administration has approved a ... Combination Niacin-Laropiprant Plus Simvastatin Reduces Cholesterol by Almost 50% - Doctors Guide, 11/6/07 - When patients ...
Chinese patients taking niacin may require lower doses of simvastatin. Ask your doctor for more details. The usual maximum dose ... It may take up to 4 weeks before you get the full benefit of this drug.Top ... Other medications can affect the removal of simvastatin from your body, which may affect how simvastatin works. Examples ... Simvastatin belongs to a group of drugs known as statins. It works by reducing the amount of cholesterol made by the liver. ...
  • Use of niacin has been considered as an adjunct therapy option in severe dyslipidemia in children ≥10 years of age and adolescents who are not achieving their goal lipid levels and not tolerating alternative therapy. (drugs.com)
  • To evaluate different methodologies for reducing cardiovascular disease incidence and progression of atherosclerosis, the authors of this paper used the statin drug simvastatin, along with slow-release niacin, given at twice-daily doses ranging from 250 mg to 1000 mg for four weeks. (jeffreybland.com)
  • Extremely high doses of niacin (available by prescription) have been shown to prevent and/or improve symptoms of the following conditions. (healthyplace.com)
  • Because of risk of toxicity people should always consult a knowledgeable health care provider before starting high doses of niacin. (healthyplace.com)
  • High doses of niacin produce the side effects of flushing of the skin (which can be reduced by taking aspirin 30 minutes before the niacin), stomach upset (which usually subsides in a few weeks), headache, dizziness, blurred vision, and liver damage. (healthyplace.com)
  • In a recent study of 125 people with diabetes and 343 people without the condition, high doses of niacin (roughly 3000 mg/day), increased blood sugar in both groups, but hemoglobin A1C (considered a better measure of blood sugar over time) actually decreased in the diabetes group over a 60-week follow-up period. (healthyplace.com)
  • This study does not validate a particular lipid target, nor does it support using interventions with neutral, harmful or conflicting evidence (fibrates, niacin, or CETP inhibitors) to achieve a lipid target. (nerdcat.org)
  • Conf rmatory cp genetic testing should be treated with a selective cox inhibitor eg, clopidogrel, the addition of niacin ir fibric acid derivatives fenofibrate gemfibrozil combination products are obtained with gadolinium, whereas typically tof mrv would be eligible for prescription of py inhibitor class iib recommendation in patients with retention of cb, bile acids, and other impairments. (roanokechowan.edu)
  • Simvastatin is a white to off-white, nonhygroscopic, crystalline powder that is practically insoluble in water and freely soluble in chloroform , methanol and ethanol. (rxlist.com)
  • Renoprotection by LA was equally effective regardless of whether the dietary supplementation was started 4 weeks before, simultaneously with, or 4 weeks after the induction of diabetes by STZ. (qualitycounts.com)
  • For this reason, if you have diabetes, niacin should only be used under the close monitoring of a qualified health care provider. (healthyplace.com)
  • However, niacin may also raise blood sugar levels, which is particularly dangerous for someone with diabetes. (limamemorial.org)
  • Researchers are studying topical forms of niacin as treatments for rosacea, aging, and prevention of skin cancer, although it is too early to know whether it is effective. (limamemorial.org)
  • Dietary supplement forms of niacin usually come in strengths of 250 mg or less. (medicinenet.com)