Warfarin: An anticoagulant that acts by inhibiting the synthesis of vitamin K-dependent coagulation factors. Warfarin is indicated for the prophylaxis and/or treatment of venous thrombosis and its extension, pulmonary embolism, and atrial fibrillation with embolization. It is also used as an adjunct in the prophylaxis of systemic embolism after myocardial infarction. Warfarin is also used as a rodenticide.Vitamin K Epoxide Reductases: OXIDOREDUCTASES which mediate vitamin K metabolism by converting inactive vitamin K 2,3-epoxide to active vitamin K.Mixed Function Oxygenases: Widely distributed enzymes that carry out oxidation-reduction reactions in which one atom of the oxygen molecule is incorporated into the organic substrate; the other oxygen atom is reduced and combined with hydrogen ions to form water. They are also known as monooxygenases or hydroxylases. These reactions require two substrates as reductants for each of the two oxygen atoms. There are different classes of monooxygenases depending on the type of hydrogen-providing cosubstrate (COENZYMES) required in the mixed-function oxidation.Anticoagulants: Agents that prevent clotting.Aryl Hydrocarbon Hydroxylases: A large group of cytochrome P-450 (heme-thiolate) monooxygenases that complex with NAD(P)H-FLAVIN OXIDOREDUCTASE in numerous mixed-function oxidations of aromatic compounds. They catalyze hydroxylation of a broad spectrum of substrates and are important in the metabolism of steroids, drugs, and toxins such as PHENOBARBITAL, carcinogens, and insecticides.Phenprocoumon: Coumarin derivative that acts as a long acting oral anticoagulant.Drug Dosage Calculations: Math calculations done for preparing appropriate doses of medicines, taking into account conversions of WEIGHTS AND MEASURES. Mistakes are one of the sources of MEDICATION ERRORS.Ticlopidine: An effective inhibitor of platelet aggregation commonly used in the placement of STENTS in CORONARY ARTERIES.Acenocoumarol: A coumarin that is used as an anticoagulant. Its actions and uses are similar to those of WARFARIN. (From Martindale, The Extra Pharmacopoeia, 30th ed, p233)Pharmacogenetics: A branch of genetics which deals with the genetic variability in individual responses to drugs and drug metabolism (BIOTRANSFORMATION).Platelet Aggregation Inhibitors: Drugs or agents which antagonize or impair any mechanism leading to blood platelet aggregation, whether during the phases of activation and shape change or following the dense-granule release reaction and stimulation of the prostaglandin-thromboxane system.International Normalized Ratio: System established by the World Health Organization and the International Committee on Thrombosis and Hemostasis for monitoring and reporting blood coagulation tests. Under this system, results are standardized using the International Sensitivity Index for the particular test reagent/instrument combination used.Drug Administration Schedule: Time schedule for administration of a drug in order to achieve optimum effectiveness and convenience.Dose-Response Relationship, Drug: The relationship between the dose of an administered drug and the response of the organism to the drug.Methimazole: A thioureylene antithyroid agent that inhibits the formation of thyroid hormones by interfering with the incorporation of iodine into tyrosyl residues of thyroglobulin. This is done by interfering with the oxidation of iodide ion and iodotyrosyl groups through inhibition of the peroxidase enzyme.Receptors, Purinergic P2Y12: A subclass of purinergic P2Y receptors that have a preference for ADP binding and are coupled to GTP-BINDING PROTEIN ALPHA SUBUNIT, GI. The P2Y12 purinergic receptors are found in PLATELETS where they play an important role regulating PLATELET ACTIVATION.Administration, Oral: The giving of drugs, chemicals, or other substances by mouth.Methadyl Acetate: A narcotic analgesic with a long onset and duration of action.Propylthiouracil: A thiourea antithyroid agent. Propythiouracil inhibits the synthesis of thyroxine and inhibits the peripheral conversion of throxine to tri-iodothyronine. It is used in the treatment of hyperthyroidism. (From Martindale, The Extra Pharmacopeoia, 30th ed, p534)ThiophenesTreatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Double-Blind Method: A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment.Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)Time Factors: Elements of limited time intervals, contributing to particular results or situations.Half-Life: The time it takes for a substance (drug, radioactive nuclide, or other) to lose half of its pharmacologic, physiologic, or radiologic activity.Drug Interactions: The action of a drug that may affect the activity, metabolism, or toxicity of another drug.Antithyroid Agents: Agents that are used to treat hyperthyroidism by reducing the excessive production of thyroid hormones.Immunoglobulins, Thyroid-Stimulating: Autoantibodies that bind to the thyroid-stimulating hormone (TSH) receptor (RECEPTORS, THYROTROPIN) on thyroid epithelial cells. The autoantibodies mimic TSH causing an unregulated production of thyroid hormones characteristic of GRAVES DISEASE.Drug Therapy, Combination: Therapy with two or more separate preparations given for a combined effect.Hemorrhage: Bleeding or escape of blood from a vessel.Prothrombin Time: Clotting time of PLASMA recalcified in the presence of excess TISSUE THROMBOPLASTIN. Factors measured are FIBRINOGEN; PROTHROMBIN; FACTOR V; FACTOR VII; and FACTOR X. It is used for monitoring anticoagulant therapy with COUMARINS.Atrial Fibrillation: Abnormal cardiac rhythm that is characterized by rapid, uncoordinated firing of electrical impulses in the upper chambers of the heart (HEART ATRIA). In such case, blood cannot be effectively pumped into the lower chambers of the heart (HEART VENTRICLES). It is caused by abnormal impulse generation.Thromboembolism: Obstruction of a blood vessel (embolism) by a blood clot (THROMBUS) in the blood stream.Purinergic P2 Receptor Antagonists: Compounds that bind to and block the stimulation of PURINERGIC P2 RECEPTORS.Platelet Function Tests: Laboratory examination used to monitor and evaluate platelet function in a patient's blood.Prospective Studies: Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.Amiodarone: An antianginal and class III antiarrhythmic drug. It increases the duration of ventricular and atrial muscle action by inhibiting POTASSIUM CHANNELS and VOLTAGE-GATED SODIUM CHANNELS. There is a resulting decrease in heart rate and in vascular resistance.Budesonide: A glucocorticoid used in the management of ASTHMA, the treatment of various skin disorders, and allergic RHINITIS.beta-Alanine: An amino acid formed in vivo by the degradation of dihydrouracil and carnosine. Since neuronal uptake and neuronal receptor sensitivity to beta-alanine have been demonstrated, the compound may be a false transmitter replacing GAMMA-AMINOBUTYRIC ACID. A rare genetic disorder, hyper-beta-alaninemia, has been reported.Prednisolone: A glucocorticoid with the general properties of the corticosteroids. It is the drug of choice for all conditions in which routine systemic corticosteroid therapy is indicated, except adrenal deficiency states.Platelet Aggregation: The attachment of PLATELETS to one another. This clumping together can be induced by a number of agents (e.g., THROMBIN; COLLAGEN) and is part of the mechanism leading to the formation of a THROMBUS.Vitamin K: A lipid cofactor that is required for normal blood clotting. Several forms of vitamin K have been identified: VITAMIN K 1 (phytomenadione) derived from plants, VITAMIN K 2 (menaquinone) from bacteria, and synthetic naphthoquinone provitamins, VITAMIN K 3 (menadione). Vitamin K 3 provitamins, after being alkylated in vivo, exhibit the antifibrinolytic activity of vitamin K. Green leafy vegetables, liver, cheese, butter, and egg yolk are good sources of vitamin K.Graves Disease: A common form of hyperthyroidism with a diffuse hyperplastic GOITER. It is an autoimmune disorder that produces antibodies against the THYROID STIMULATING HORMONE RECEPTOR. These autoantibodies activate the TSH receptor, thereby stimulating the THYROID GLAND and hypersecretion of THYROID HORMONES. These autoantibodies can also affect the eyes (GRAVES OPHTHALMOPATHY) and the skin (Graves dermopathy).Recurrence: The return of a sign, symptom, or disease after a remission.Genotype: The genetic constitution of the individual, comprising the ALLELES present at each GENETIC LOCUS.Ethanolamines: AMINO ALCOHOLS containing the ETHANOLAMINE; (-NH2CH2CHOH) group and its derivatives.Polymorphism, Single Nucleotide: A single nucleotide variation in a genetic sequence that occurs at appreciable frequency in the population.Haplotypes: The genetic constitution of individuals with respect to one member of a pair of allelic genes, or sets of genes that are closely linked and tend to be inherited together such as those of the MAJOR HISTOCOMPATIBILITY COMPLEX.Pathology, Veterinary: The field of veterinary medicine concerned with the causes of and changes produced in the body by disease.Encyclopedias as Topic: Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)Magnesium Compounds: Inorganic compounds that contain magnesium as an integral part of the molecule.Surgical Procedures, Minor: Surgery restricted to the management of minor problems and injuries; surgical procedures of relatively slight extent and not in itself hazardous to life. (Dorland, 28th ed & Stedman, 25th ed)Cattle Diseases: Diseases of domestic cattle of the genus Bos. It includes diseases of cows, yaks, and zebus.Melilotus: A plant genus of the family FABACEAE.
Treatment with a corticosteroid plus low-dose aspirin followed by maintenance therapy with an anabolic steroid where necessary ... anticoagulants such as heparin and warfarin, and immunosuppressive drug regimens such as a corticosteroid (e.g. prednisone) ...
... and CYP4F2 polymorphisms on warfarin maintenance dose in children aged less than 18 years: a protocol for systematic review and ... Lower warfarin doses are needed to inhibit VKORC1 and to produce an anticoagulant effect in carriers of the A allele. Genetic ... Inappropriate dosing of warfarin has been associated with a substantial risk of both major and minor hemorrhage. As the ... Zhang J, Tian L, Zhang Y, Shen J (November 2015). "The influence of VKORC1 gene polymorphism on warfarin maintenance dosage in ...
... have been distilled to help manage dose adjustments. The maintenance dose of warfarin can fluctuate significantly depending on ... major being 7-OH warfarin formed from S-warfarin by CYP2C9 and 10-OH warfarin from R-warfarin by CYP3A4. Warfarin is slower ... Drug Information Portal-Warfarin Warfarin bound to proteins in the PDB: R-warfarin, S-warfarin CDC - NIOSH Pocket Guide to ... reduces the effectiveness of a given dose of warfarin; it induces the enzymes that break down warfarin in the body, causing a ...
Maintenance doseEdit. Vitamin K1-warfarin interaction effect. When warfarin levels are high, people have more risk of bleeding ... The maintenance dose of warfarin can fluctuate significantly depending on the amount of vitamin K1 in the diet. Keeping vitamin ... DosingEdit. Dosing of warfarin is complicated because it is known to interact with many commonly used medications and certain ... major being 7-OH warfarin formed from S-warfarin by CYP2C9 and 10-OH warfarin from R-warfarin by CYP3A4.[68] ...
... "maintenance dose"). It is an extremely effective antidote, provided the poisoning is caught before excessive bleeding ensues. ... She was tested for warfarin, a common anticoagulant also used in some rodenticides, which returned a negative result. Vitamin K ... As high doses of brodifacoum can affect the body for many months, the antidote must be administered regularly for a long period ... Continual doses of Vitamin K were necessary to counteract the Brodifacoum. He denied taking any of the Brodifacoum found in his ...
Consider using decreased maintenance dose. Kidney disease: Do not use oral loading dose. Can begin with standard maintenance ... Patients should be cautioned against concomitant use of antacids and phenytoin." Warfarin (Coumadin) and trimethoprim increase ... At therapeutic doses, phenytoin may produce nystagmus on lateral gaze. At toxic doses, patients experience vertical nystagmus, ... The wholesale cost in the developing world is between US$0.003 and US$0.15 per dose. A month of treatment is about US$30 in the ...
The recurrence of rheumatic fever is relatively common in the absence of maintenance of low dose antibiotics, especially during ... such as aspirin or warfarin. In rare instances when mitral valve prolapse is associated with severe mitral regurgitation, ...
aTotal body clearance/F = Dose/AUC bSteady state volume of distribution/F = Dose•AUMC/AUC2 cVolume of distribution (area)/F = ... It exerts its antibacterial effect by interfering with the bacterial enzyme DNA gyrase, which is needed for the maintenance and ... It inhibits the metabolism of theophylline, caffeine, cyclosporine and warfarin. Azlocillin, cimetidine and probenecid increase ... The minimum dose (5 mg/kg) was confirmed in a clinical trial performed by HTI Bio-services, Inc. It evaluated the effective ...
Doses should be taken as prescribed, due to risk of liver toxicity with overdoses. In France, the country's health agency ... such as warfarin. NSAIDs may aggravate hypertension (high blood pressure) and thereby antagonize the effect of ... they are expensive for maintenance therapy. NSAIDs should be used with caution in individuals with inflammatory bowel disease ( ... In people with such a history, use of NSAIDs (aside from low-dose aspirin) was associated with a more than 10-fold increase in ...
... achieved at the maximum recommended human daily oral dose, respectively). In dogs, at an oral dose of 1000 mg/kg (providing in ... The R-isomer of warfarin metabolism and clearance is mainly affected by zileuton, while the S-isomer is not (because of ... used for the maintenance treatment of asthma. Zileuton was introduced in 1996 by Abbott Laboratories and is now marketed in two ... The recommended dose of ZYFLO is one 600 mg tablet, four times per day. The tablets may be split in half to make them easier to ...
... is sometimes used in systemic lupus erythematosus patients who require a maintenance dose of 15 mg or higher of ... Azathioprine decreases the effects of the anticoagulant warfarin and of non-depolarizing muscle relaxants, but increases the ... Large single doses are generally well tolerated; a patient who took 7.5 g azathioprine (150 tablets) at once showed no relevant ... Lower doses of azathioprine are used as a therapy in children with refractory or corticosteroid-dependent Crohn's disease, ...
Higher doses (,450 mg/day) may be more effective in severe depression, while patients treated with a lower dose tend to respond ... Duncan D, Sayal K, McConnell H, Taylor D (March 1998). "Antidepressant interactions with warfarin". Int Clin Psychopharmacol. ... Treatment is largely symptomatic and should be aimed at maintenance of the vital functions. ... Moclobemide, even at high doses of 600 mg, does not impair the ability to drive a motor vehicle.[8][63] The tolerability of ...
Single 20 to 40 mg oral doses generally give rise to peak plasma esomeprazole concentrations of 0.5-1.0 mg/l within 1-4 hours, ... The primary uses of esomeprazole are gastroesophageal reflux disease, treatment and maintenance of erosive esophagitis, ... such as diazepam and warfarin; the concentrations of these drugs may increase if they are used concomitantly with esomeprazole ... A 30-minute intravenous infusion of a similar dose usually produces peak plasma levels on the order of 1-3 mg/l. The drug is ...
Consider using decreased maintenance dose.. *Kidney disease: Do not use oral loading dose. Can begin with standard maintenance ... Warfarin (Coumadin) and trimethoprim increase serum phenytoin levels and prolong the serum half-life of phenytoin by inhibiting ... At therapeutic doses, phenytoin may produce nystagmus on lateral gaze. At toxic doses, patients experience vertical nystagmus, ... Obese: Use ideal body weight for dosing calculations.. *Pregnancy: Pregnancy Category D due to risk of fetal hydantoin syndrome ...
However, lisinopril is dosed once a day, whereas captopril may be dosed 2-3 times a day. Assuming that there are no ... such as with warfarin, as it may lose its effect. Patients at greatest risk for negative polypharmacy consequences include the ... including hypnotics or analgesic inducing/maintenance agents such as Versed or Diprivan, usually an opioid analgesic such as ... PRIMA-eds is an algorithm that takes many patient factors into its calculations and can offer medication and dosing ...
... but only at doses at least 20 times greater than the recommended human dose on a milligram/kilogram basis. Ramelteon has been ... digoxin and warfarin. There were no clinically meaningful effects when ramelteon was coadministered with any of these drugs. A ... are thought to be involved in the maintenance of the circadian rhythm underlying the normal sleep-wake cycle. Ramelteon has no ...
Reproduction studies have been performed in female laboratory rabbits, mice, and rats at doses up to 1.3, 7, and 9 times the ... Dosages of 50 mg to 75 mg daily are usually satisfactory as maintenance therapy for elderly patients who do not tolerate higher ... Maprotiline may amplify the actions of coumarin-type anticogulants (e.g. warfarin, phenprocoumon). The plasma-prothrombin- ... At higher doses however, maprotiline increases serotonergic transmission and increases the level of serotonin available. After ...
Although the doses employed in these studies were a multiple of those used in human beings no adverse effects on the offspring ... The decision whether maintenance therapy with these drugs should be discontinued during tirofiban treatment has to be made by ... The concomitant application of warfarin or other oral anticoagulants may increase the risk of serious bleeding events. ...
released a study in 2010 indicating that there may be associated male infertility in the unborn.[67][68] Doses should be taken ... they are expensive for maintenance therapy.[citation needed] ... such as warfarin.[74]. NSAIDs may aggravate hypertension (high ... To minimize GI side effects, it is prudent to use the lowest effective dose for the shortest period of time-a practice that ... NSAIDs aside from (low-dose) aspirin are associated with a doubled risk of heart failure in people without a history of cardiac ...
At low doses, these SNRIs act mostly as SSRIs; only at higher doses do they also prominently inhibit norepinephrine reuptake. ... In 2014 the U.S. FDA published a systematic review of all antidepressant maintenance trials submitted to the agency between ... SSRIs interact with anticoagulants, like warfarin and aspirin. This includes an increased risk of GI bleeding, and post ... On chronic dosing, the increased occupancy of post-synaptic serotonin receptors signals the pre-synaptic neuron to synthesize ...
"Adjusted-dose warfarin versus low-intensity, fixed-dose warfarin plus aspirin for high-risk patients with atrial fibrillation: ... 2007). "Dronedarone for maintenance of sinus rhythm in atrial fibrillation or flutter". N. Engl. J. Med. 357 (10): 987-99. doi: ... the combination of aspirin and the lower dose of warfarin was significantly inferior to the standard adjusted-dose warfarin ( ... A combination of aspirin and fixed-dose warfarin (initial INR 1.2-1.5) was tried. Unfortunately, in a study of AF patients with ...
... also as a loading dose, with the dose depending on whether further surgical management or fibrinolysis is planned. Prasugrel ... ATP is required for the maintenance of electrolyte balance, particularly through the Na/K ATPase. This leads to an ischemic ... If someone has another medical condition that requires anticoagulation (e.g. with warfarin) this may need to be adjusted based ... The dose should be increased to the highest tolerated. Contrary to what was long believed, the use of beta blockers does not ...
Including a loading dose and maintenance therapy in those receiving PCI and unable to tolerate aspirin therapy ... Following an oral dose of 14C-labeled clopidogrel in humans, about 50% was excreted in the urine and 46% in the feces in the ... A loading dose given in advance of percutaneous coronary intervention (PCI), followed by a full year of treatment for those ... Maintenance therapy for up to 12 months in those at medium to high risk for which a noninvasive treatment strategy is chosen ...
... dose - dose-dense chemotherapy - dose-dependent - dose-limiting - dose-rate - dosimetrist - double-blinded - double-contrast ... warfarin - wedge resection - Wermer's syndrome - Whipple procedure - white blood cell - Whitmore-Jewett staging system - whole ... maintenance therapy - malabsorption syndrome - malignancy - malignant - malignant ascites - malignant fibrous cytoma - ... high-dose chemotherapy - high-dose-rate remote brachytherapy - high-dose-rate remote radiation therapy - high-energy photon ...
Warfarin treatment requires blood monitoring and dose adjustments regularly due to its narrow therapeutic window. If ... Davie, E.W.; Fujikawa, K; Kisiel, W (1991). "The coagulation cascade: initiation, maintenance, and regulation". Biochemistry. ... He and his colleagues worked on several variations and ended up with a substance they named warfarin in 1948. It wasn't until ... Direct Xa inhibitors are just as efficacious as LMWH and warfarin but they are given orally and don't need as strict monitoring ...
Persons taking the anticoagulant warfarin Any statin The statin use may require that the warfarin dose be changed, as some ... as mevalonate is a precursor of many substances required by organisms for the maintenance of their cell walls or cytoskeleton ( ... "Risk of incident diabetes with intensive-dose compared with moderate-dose statin therapy: a meta-analysis". JAMA. 305 (24): ... Starting dose. 10-20 mg. 20 mg. 10-20 mg. 40 mg. 10 mg; 5 mg if hypothyroid, ,65 yo, Asian. 20 mg ...
Results: Data from 107 subjects undergoing maintenance warfarin therapy with an international normalized ratio stabilized ... can accurately predict warfarin doses. The aims of this study were to derive a pharmacogenetics-based dosing algorithm by use ... Tham, L.-S., Goh, B.-C., Nafziger, A., Guo, J.-Y., Wang, L.-Z., Soong, R., Lee, S.-C. (2006-10). A warfarin-dosing model in ... A warfarin-dosing model in Asians that uses single-nucleotide polymorphisms in vitamin K epoxide reductase complex and ...
... maintenance dose or at a loading dose (1.5 times the maintenance dose for 3 days, then resumption of warfarin dosing as per ... maintenance dose or at a loading dose (1.5 times the maintenance dose for 3 days, then resumption of warfarin dosing as per ... 1.5 times the maintenance dose for 3 days, then resumption of warfarin dosing as per the maintenance dose ... Re-start same dose as previously stable on. Drug: Warfarin Maintenance dose is the amount of warfarin that a patient required ...
Assessing the Clinical Benefits of a Pharmacogenetics-Guided Dosing Regiment for Calculating Warfarin Maintenance Dose. This ... Drug: Warfarin Sodium All predicted warfarin dose will be administered by rounding down to the nearest 0.5 mg. Warfarin ( ... Drug: Warfarin Sodium All predicted warfarin dose will be administered by rounding down to the nearest 0.5 mg. Warfarin ( ... Our previous studies showed that warfarin maintenance doses in our multi-ethnic population were closely related to patient ...
We tested our hypothesis that plasma metabolite levels correlate with the influence of clinical factors on R-warfarin and S- ... we leveraged metabolite patterns for warfarin patients to more accurately assess clinically relevant differences in drug ... Novel isomeric metabolite profiles correlate with warfarin metabolism phenotype during maintenance dosing in a pilot study of ... warfarin metabolic phenotype). We recruited 29 patients receiving a maintenance dose and testing within targeted therapeutic ...
Warfarin Sodium Tablets) may treat, uses, dosage, side effects, drug interactions, warnings, patient labeling, reviews, and ... Select the initial dose based on the expected maintenance dose, taking into account the above factors. Modify this dose based ... Asian patients may require lower initiation and maintenance doses of warfarin. A non-controlled study of 151 Chinese ... Typical maintenance doses are 2 to 10 mg once daily.. Dosing Recommendations With Consideration Of Genotype. Table 1 displays ...
Maintenance doseEdit. Vitamin K1-warfarin interaction effect. When warfarin levels are high, people have more risk of bleeding ... The maintenance dose of warfarin can fluctuate significantly depending on the amount of vitamin K1 in the diet. Keeping vitamin ... DosingEdit. Dosing of warfarin is complicated because it is known to interact with many commonly used medications and certain ... major being 7-OH warfarin formed from S-warfarin by CYP2C9 and 10-OH warfarin from R-warfarin by CYP3A4.[68] ...
title = "A simple technic for predicting daily maintenance dose of warfarin",. abstract = "Warfarin anticoagulation data from ... accurate prediction of a daily maintenance dose of warfarin.. AB - Warfarin anticoagulation data from forty-seven patients ... Daily maintenance dose (mg/day) = 0.0465 × (AREA) + 1.5. The correlation was then used to predict daily maintenance dose in ... Daily maintenance dose (mg/day) = 0.0465 × (AREA) + 1.5. The correlation was then used to predict daily maintenance dose in ...
2.3 Initial and Maintenance Dosing. The appropriate initial dosing of warfarin sodium varies widely for different patients. Not ... 2.5 Missed Dose. The anticoagulant effect of warfarin sodium persists beyond 24 hours. If a patient misses a dose of warfarin ... Select the initial dose based on the expected maintenance dose, taking into account the above factors. Modify this dose based ... Table 1Three Ranges of Expected Maintenance Warfarin Sodium Daily Doses Based on CYP2C9 and VKORC1 Genotypes† †Ranges are ...
Warfarin is an anticoagulant that inhibits vitamin K-dependent clotting factors including factor (F) II, FVII, FIX and FX. ... A Genotypes on Estimated Warfarin Maintenance Dose in Iranian Patients Under Warfarin Therapy Fariba Rad 1 , Mohsen Hamidpour 2 ... Correlation plots of the statistical analysis between warfarin dose and age. Our data revealed that warfarin dose was ... A Genotypes on Estimated Warfarin Maintenance Dose in Iranian Patients Under Warfarin Therapy Fariba Rad et al. Indian J ...
We confirmed the important role of VKORC1 and CYP2C9 polymorphisms in warfarin dose. Original submitted 14 January 2015; ... Genome-wide association study of warfarin maintenance dose in a Brazilian sample Esteban J Parra 1 , Mariana R Botton 2 , ... Genome-wide association study of warfarin maintenance dose in a Brazilian sample Esteban J Parra et al. Pharmacogenomics. 2015 ... Identification of two novel genes SLC15A2 and SLCO1B3 associated with maintenance dose variability of warfarin in a Chinese ...
VKORC1 polymorphisms and warfarin maintenance dose in population of Sakha (Yakuts). - PubMed - NCBI. Int J Risk Saf Med. 2015 ... The median maintenance daily dose of warfarin among AA carriers was 3.0 mg/day [1.25-7.5 mg], while in GG and GA patients it ... VKORC1 polymorphisms and warfarin maintenance dose in population of Sakha (Yakuts).. Chertovskikh YV1,2, Malova EU3, Maksimova ... VKORC1 polymorphisms and warfarin maintenance dose in population of Sakha (Yakuts). - PubMed - NCBI ...
Such variability, specifically in clearance rates, can influence drug maintenance dosing regimens. ... genetic polymorphisms on warfarin maintenance dose and metabolic clearance. Clin Pharmacol Ther 2002;72;(6):702-710. ... "dosing regimen" may include three components-loading dose, maintenance dose, and dosing interval-that are inherently influenced ... MAINTENANCE DOSE, CLEARANCE, AND GENETIC VARIATION. From a PK point of view, the maintenance dose of a drug is meant to replace ...
CYP2C9, VKORC1, and CYP4F2 polymorphisms and pediatric warfarin maintenance dose: a systematic review and meta-analysis * ... polymorphisms and pediatric warfarin maintenance dose: a systematic review and meta-analysis . Opens in a new window. ...
but its contribution to warfarin upkeep dose in the Japanese and Egyptians was relatively small when compared with the effects ... but its contribution to warfarin maintenance dose in the Japanese and. [41, 42] but its contribution to warfarin upkeep dose in ... 51.eight of the patients all round obtaining predicted imply weekly warfarin dose within 20 of your actual maintenance dose [48 ... 51.eight on the patients general possessing predicted imply weekly warfarin dose inside 20 from the actual maintenance dose [48 ...
Effect of CYP2C9 and VKORC1 polymorphisms on warfarin dose, anticoagulation attainment and maintenance among European American ...
Effects of inflammatory cytokine gene polymorphisms on warfarin maintenance doses in Korean patients with mechanical cardiac ... Effects of inflammatory cytokine gene polymorphisms on warfarin maintenance doses in Korean patients with mechanical cardiac ... Cytokine genes; Genotype; INR; Stable dose; Warfarin. DOI. 10.1007/s12272-013-0221-4. Appears in Collections:. 약학대학 , 약학과 , ...
Influence of Genotype on Warfarin Maintenance Dose Predictions Produced Using a Bayesian Dose Individualization Tool. Saffian, ... Efficiency and Safety of an Early Dose Adjustment of Ribavirin in Patients Infected With Hepatitis C Underexposed to the Drug ... Identification of Different Patterns of Dabigatran In Vivo Bioactivation in Patients on Maintenance Anticoagulation Therapy. ...
Warfarin‡. Daily loading then maintenance doses. based PT and INR values. Quicks Value = 35 ± 5% ... To minimize the risk of hypoglycemia, the initial dosing, dose increments, and maintenance dosage of Duetact should be ... To minimize the risk of hypoglycemia, the initial dosing, dose increments and maintenance dosage of Duetact should be ... 0.250 mg twice daily (loading dose) then. 0.250 mg daily (maintenance dose, 7 days) ...
Dosing algorithms to predict warfarin maintenance dose in Caucasians and African Americans. Clinical Pharmacology and ... 69. Yin, T, Miyata, T. Warfarin dose and the pharmacogenomics of CYP2C9 and VKORC1 - rationale and perspectives. Thrombosis ... Effect of CYP2C9 and VKORC1 genetic variations on warfarin dose requirements in Indian patients. Pharmacological Reports 2013; ... Association of polymorphisms in the cytochrome P450 CYP2C9 with warfarin dose requirement and risk of bleeding complications. ...
Warfarin maintenance dose Title A genome-wide scan for common genetic variants with a large influence on warfarin maintenance ...
The aim of this study was to assess the pharmacokinetics and pharmacodynamics of warfarin associated with genetic polymor ... 2012) CYP4F2 gene polymorphism as a contributor to warfarin maintenance dose in Japanese subjects. J Clin Pharm Ther 37(4):481- ... 89 of whom were treated with a fixed daily dose of warfarin (1 mg). The plasma concentrations of S- and R-warfarin and S- and R ... Influence of CYP2C9 and CYP2C19 genetic polymorphisms on warfarin maintenance dose and metabolic clearance. Clin Pharmacol Ther ...
Oral Anticoagulants -- warfarin sodium (Coumadin) (1): 1.) Initial dose: 10 mg/day. 2.) Daily maintenance dose:. -2 - 10 mg/day ... 12-24 hrs after first dose. Depresses Prothrombin . Monitor: Prothrombin time (PT) ...
The variability in warfarin dose requirement is attributable to genetic and environmental factors. Acenocoumarol (AC) and ... Compared to patients with the VKORC1 C1173C genotype, maintenance doses for AC or PC were reduced to 74.6 or 70.2% in ... Genetic determinants of acenocoumarol and phenprocoumon maintenance dose requirements.. Cadamuro J1, Dieplinger B, Felder T, ... These results reveal that interindividual variability in weekly AC and PC maintenance dose requirement is mainly dependent on ...
Once maintenance dosing begins, the frequency of INR testing and any dose adjustments are determined by the proximity of the ... Stop warfarin.. Repeat INR the next day and adjust to warfarin dose to maintain INR in the therapeutic range. If bleeding risk ... How to change from warfarin to dabigatran. Warfarin should be withdrawn and dabigatran initiated at the normal dose after ... Warfarin doses often need to be adjusted to optimise the time patients spend within the therapeutic range. As co-morbidities ...
Daily loading then maintenance doses based PT and INR values Quicks Value = 35 ± 5%. R-Warfarin. ↓3%. ↓2%. ... 0.200 mg twice daily (loading dose) then 0.250 mg daily (maintenance dose, 7 days). ↑15%. ↑17%. ... dosing duration of 91 weeks) at doses up to and including 900 mg/kg/day and 1500 mg/kg/day, respectively. These doses are both ... Dose Regimen (mg)*. Change in ACC†. Change in Cmax†. Gemfibrozil 600 mg twice daily for 2 days (N = 12). 15-mg single dose. ↑ ...
  • The aim of our study was to investigate the contribution of genes involved in the vitamin K cycle to AC and PC maintenance doses. (nih.gov)
  • No associations with AC or PC dose requirements were observed for sequence substitutions in the GGCX or APOE genes. (nih.gov)
  • Additionally, people who have more than one polymorphism in a gene or polymorphisms in multiple genes associated with warfarin sensitivity have a lower tolerance for the drug's effect or take even longer to clear the drug from their body. (medlineplus.gov)
  • Effect of functional CYP2D6 genes in mean plasma concentrations of nortriptyline after a 25-mg oral dose administration. (intechopen.com)
  • In particular, we use drug pathways and expression quantitative trait loci knowledge to impute gene expression-on the assumption that differential expression of key pathway genes may impact dose requirement. (biomedcentral.com)
  • We focus on 116 genes from the pharmacokinetic and pharmacodynamic pathways of warfarin within training and validation sets comprising both European and African-descent individuals. (biomedcentral.com)
  • Neste sentido, o presente estudo teve como objetivos investigar a associação de polimorfismos nos genes ABCB1 e CYP4F2 com a variabilidade do requerimento de dose de varfarina, e, primariamente, avaliar o impacto da inclusão desses polimorfismos como covariáveis do algoritmo farmacogenético estimador de dosagem de varfarina previamente desenvolvido para a população brasileira por Santos et al. (usp.br)
  • Para as análises estatísticas, utilizamos a abordagem de regressão linear múltipla, considerando a dose estável de varfarina como variável resposta e como covariáveis os polimorfismos de interesse nos genes ABCB1 e CYP4F2, bem como outros fatores genéticos, clínicos e demográficos. (usp.br)
  • A and CYP2C9 genotype variations affected the pharmacokinetics and pharmacodynamics of warfarin, while we could not find significant effects of CYP4F2 or CYP2C19 genotype variations on warfarin (metabolite) concentrations or PT-INR. (springer.com)
  • Além disso, verificamos que ambos os polimorfismos ABCB1 c.3435C>T e CYP4F2 c.1297G>A contribuíram para a predição de dose de varfarina, quando associados a outros fatores genotípicos, demográficos e clínicos relevantes, sendo estatisticamente significativos, aumentando o coeficiente de determinação do algoritmo em 2,6% e explicando um adicional de 3,6% da variabilidade interindividual de dosagem. (usp.br)
  • Many other medications and dietary factors can interact with warfarin, either increasing or decreasing its effectiveness. (wikipedia.org)
  • Many commonly used medications interact with warfarin, as do some foods (particularly leaf vegetable foods or "greens," since these typically contain large amounts of vitamin K 1 ) and its activity has to be monitored by blood testing for the international normalized ratio (INR) to ensure an adequate yet safe dose is taken. (gutenberg.org)
  • 7 In this population, it is more frequent to see clinical intercurrences, changes in diet, use of drugs that interact with warfarin reported in the literature and the need for a pharmaceutical derivation using pills, due to the unavailability of the pharmaceutical form and doses that are adequate to the age group. (scielo.br)
  • Extreme discordant phenotype and genome-wide association (GWA) approaches were combined to explore the role of genetic variants on warfarin dose requirement in Brazilians. (cdc.gov)
  • What are the genetic variants contributing to warfarin dose requirements in African Americans? (acc.org)
  • Known genetic variants with effects on important clinical phenotypes, including clopidogrel efficacy and warfarin maintenance dose, highlight the potential translational utility of pharmacogenetic analysis. (washington.edu)
  • After initiation of Duetact and after dose increases, monitor patients carefully for signs and symptoms of heart failure (e.g., excessive, rapid weight gain, dyspnea, and/or edema). (drugs.com)
  • The effect of rifampin on the warfarin requirement of our patient appeared to be maximal 5 to 7 days after the initiation of rifampin and extended a similar length of time after rifampin withdrawal. (annals.org)
  • We impute gene expression in specific tissues for each individual using the GTEx compendium [ 11 ] (Fig. 1 ) and learn a signature that is predictive of warfarin dose comprising gene-tissue pairs on a training cohort. (biomedcentral.com)
  • Upon reaching steady-state, pharmacokinetics of warfarin R- and S-enantiomers will be determined for correlation with dose requirements and genotypes based on a single 5ml blood sample taken after achieving target INR without a change in dose for at least 3 months. (clinicaltrials.gov)
  • In this study, we investigated the correlation between CYP2C9 gene polymorphism and maintenance dose of Warfarin in 300 patients who were the Han population derived from the Affiliated Yan An Hospital of Kunming Medical University in Yunnan Province of China, subjected to the operation of cardiac valve replacement and Warfarin oral administration post operation from 2008 to 2009 by detecting the genotypes and Allele. (academicjournals.org)
  • After the prespecified conditioning in the discovery cohort, the authors identified an association between a novel single nucleotide polymorphism (SNP) in the CYP2C cluster on chromosome 10 (rs12777823) and warfarin dose requirement that reached genome-wide significance (p = 1.51 × 10 -8 ). (acc.org)
  • A number of resources provide great breadth and depth on this subject, including The Pharmacogenomics Knowledgebase (PharmGKB, www.pharmgkb.org ) and genetic-based dosing guidelines from the Clinical Pharmacogenetic Implementation Consortium (CPIC, www.pharmgkb.org/page/cpic ) and the Dutch Pharmacogenetics Working Group (DPWG, www.pharmgkb.org/page/dpwg ), which can also be accessed via the PharmGKB website. (ptcommunity.com)