An alpha-globulin found in the plasma of man and other vertebrates. It is apparently synthesized in the liver and carries vitamin D and its metabolites through the circulation and mediates the response of tissue. It is also known as group-specific component (Gc). Gc subtypes are used to determine specific phenotypes and gene frequencies. These data are employed in the classification of population groups, paternity investigations, and in forensic medicine.
A vitamin that includes both CHOLECALCIFEROLS and ERGOCALCIFEROLS, which have the common effect of preventing or curing RICKETS in animals. It can also be viewed as a hormone since it can be formed in SKIN by action of ULTRAVIOLET RAYS upon the precursors, 7-dehydrocholesterol and ERGOSTEROL, and acts on VITAMIN D RECEPTORS to regulate CALCIUM in opposition to PARATHYROID HORMONE.
A publication issued at stated, more or less regular, intervals.
Factors secreted by stimulated lymphocytes that prime macrophages to become nonspecifically cytotoxic to tumors. They also modulate the expression of macrophage cell surface Ia antigens. One MAF is INTERFERON-GAMMA. Other factors antigenically distinct from IFN-gamma have also been identified.
A quantitative measure of the frequency on average with which articles in a journal have been cited in a given period of time.
Individual's rights to obtain and use information collected or generated by others.
The major circulating metabolite of VITAMIN D3. It is produced in the LIVER and is the best indicator of the body's vitamin D stores. It is effective in the treatment of RICKETS and OSTEOMALACIA, both in azotemic and non-azotemic patients. Calcifediol also has mineralizing properties.
The minor fragment formed when C5 convertase cleaves C5 into C5a and COMPLEMENT C5B. C5a is a 74-amino-acid glycopeptide with a carboxy-terminal ARGININE that is crucial for its spasmogenic activity. Of all the complement-derived anaphylatoxins, C5a is the most potent in mediating immediate hypersensitivity (HYPERSENSITIVITY, IMMEDIATE), smooth MUSCLE CONTRACTION; HISTAMINE RELEASE; and migration of LEUKOCYTES to site of INFLAMMATION.
A physiologically active metabolite of VITAMIN D. The compound is involved in the regulation of calcium metabolism, alkaline phosphatase activity, and enhances the calcemic effect of CALCITRIOL.
A mitochondrial cytochrome P450 enzyme that catalyzes the 1-alpha-hydroxylation of 25-hydroxyvitamin D3 (also known as 25-hydroxycholecalciferol) in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP27B1 gene, converts 25-hydroxyvitamin D3 to 1-alpha,25-dihydroxyvitamin D3 which is the active form of VITAMIN D in regulating bone growth and calcium metabolism. This enzyme is also active on plant 25-hydroxyvitamin D2 (ergocalciferol).
Bovine respiratory disease found in animals that have been shipped or exposed to CATTLE recently transported. The major agent responsible for the disease is MANNHEIMIA HAEMOLYTICA and less commonly, PASTEURELLA MULTOCIDA or HAEMOPHILUS SOMNUS. All three agents are normal inhabitants of the bovine nasal pharyngeal mucosa but not the LUNG. They are considered opportunistic pathogens following STRESS, PHYSIOLOGICAL and/or a viral infection. The resulting bacterial fibrinous BRONCHOPNEUMONIA is often fatal.
Large vessels propelled by power or sail used for transportation on rivers, seas, oceans, or other navigable waters. Boats are smaller vessels propelled by oars, paddles, sail, or power; they may or may not have a deck.
The means of moving persons, animals, goods, or materials from one place to another.
The practice of medicine concerned with conditions affecting the health of individuals associated with the marine environment.
Infections with bacteria of the genus PASTEURELLA.
A species of gram-negative, facultatively anaerobic, rod-shaped bacteria normally commensal in the flora of CATTLE and SHEEP. But under conditions of physical or PHYSIOLOGICAL STRESS, it can cause MASTITIS in sheep and SHIPPING FEVER or ENZOOTIC CALF PNEUMONIA in cattle. Its former name was Pasteurella haemolytica.
Form in which product is processed or wrapped and labeled. PRODUCT LABELING is also available.
A subclass of retinol-binding proteins that take part in the intracellular storage and transport of RETINOL. They are both functionally and structurally distinct from PLASMA RETINOL-BINDING PROTEINS.
Proteins which bind with RETINOL. The retinol-binding protein found in plasma has an alpha-1 mobility on electrophoresis and a molecular weight of about 21 kDa. The retinol-protein complex (MW=80-90 kDa) circulates in plasma in the form of a protein-protein complex with prealbumin. The retinol-binding protein found in tissue has a molecular weight of 14 kDa and carries retinol as a non-covalently-bound ligand.
Retinol and derivatives of retinol that play an essential role in metabolic functioning of the retina, the growth of and differentiation of epithelial tissue, the growth of bone, reproduction, and the immune response. Dietary vitamin A is derived from a variety of CAROTENOIDS found in plants. It is enriched in the liver, egg yolks, and the fat component of dairy products.
Retinol binding proteins that circulate in the PLASMA. They are members of the lipocalin family of proteins and play a role in the transport of RETINOL from the LIVER to the peripheral tissues. The proteins are usually found in association with TRANSTHYRETIN.
An important regulator of GENE EXPRESSION during growth and development, and in NEOPLASMS. Tretinoin, also known as retinoic acid and derived from maternal VITAMIN A, is essential for normal GROWTH; and EMBRYONIC DEVELOPMENT. An excess of tretinoin can be teratogenic. It is used in the treatment of PSORIASIS; ACNE VULGARIS; and several other SKIN DISEASES. It has also been approved for use in promyelocytic leukemia (LEUKEMIA, PROMYELOCYTIC, ACUTE).
Uptake of substances through the lining of the INTESTINES.
A nutritional condition produced by a deficiency of VITAMIN D in the diet, insufficient production of vitamin D in the skin, inadequate absorption of vitamin D from the diet, or abnormal conversion of vitamin D to its bioactive metabolites. It is manifested clinically as RICKETS in children and OSTEOMALACIA in adults. (From Cecil Textbook of Medicine, 19th ed, p1406)
Reduction of the blood calcium below normal. Manifestations include hyperactive deep tendon reflexes, Chvostek's sign, muscle and abdominal cramps, and carpopedal spasm. (Dorland, 27th ed)
Stable calcium atoms that have the same atomic number as the element calcium, but differ in atomic weight. Ca-42-44, 46, and 48 are stable calcium isotopes.
Calcium compounds used as food supplements or in food to supply the body with calcium. Dietary calcium is needed during growth for bone development and for maintenance of skeletal integrity later in life to prevent osteoporosis.
Disorders caused by interruption of BONE MINERALIZATION manifesting as OSTEOMALACIA in adults and characteristic deformities in infancy and childhood due to disturbances in normal BONE FORMATION. The mineralization process may be interrupted by disruption of VITAMIN D; PHOSPHORUS; or CALCIUM homeostasis, resulting from dietary deficiencies, or acquired, or inherited metabolic, or hormonal disturbances.
Proteins that bind to the 3' polyadenylated region of MRNA. When complexed with RNA the proteins serve an array of functions such as stabilizing the 3' end of RNA, promoting poly(A) synthesis and stimulating mRNA translation.
Proteins, usually found in the cytoplasm, that specifically bind calcitriol, migrate to the nucleus, and regulate transcription of specific segments of DNA with the participation of D receptor interacting proteins (called DRIP). Vitamin D is converted in the liver and kidney to calcitriol and ultimately acts through these receptors.
Granular leukocytes having a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes.
Messages between computer users via COMPUTER COMMUNICATION NETWORKS. This feature duplicates most of the features of paper mail, such as forwarding, multiple copies, and attachments of images and other file types, but with a speed advantage. The term also refers to an individual message sent in this way.
The lipid- and protein-containing, selectively permeable membrane that surrounds the cytoplasm in prokaryotic and eukaryotic cells.
Techniques to partition various components of the cell into SUBCELLULAR FRACTIONS.
Cells lining the outside of the BLASTOCYST. After binding to the ENDOMETRIUM, trophoblasts develop into two distinct layers, an inner layer of mononuclear cytotrophoblasts and an outer layer of continuous multinuclear cytoplasm, the syncytiotrophoblasts, which form the early fetal-maternal interface (PLACENTA).
A nodular organ in the ABDOMEN that contains a mixture of ENDOCRINE GLANDS and EXOCRINE GLANDS. The small endocrine portion consists of the ISLETS OF LANGERHANS secreting a number of hormones into the blood stream. The large exocrine portion (EXOCRINE PANCREAS) is a compound acinar gland that secretes several digestive enzymes into the pancreatic ductal system that empties into the DUODENUM.
Separation of particles according to density by employing a gradient of varying densities. At equilibrium each particle settles in the gradient at a point equal to its density. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
The mucous membrane lining of the uterine cavity that is hormonally responsive during the MENSTRUAL CYCLE and PREGNANCY. The endometrium undergoes cyclic changes that characterize MENSTRUATION. After successful FERTILIZATION, it serves to sustain the developing embryo.
The neck portion of the UTERUS between the lower isthmus and the VAGINA forming the cervical canal.
Tumors or cancer of the UTERINE CERVIX.
The reproductive organ (GONADS) in female animals. In vertebrates, the ovary contains two functional parts: the OVARIAN FOLLICLE for the production of female germ cells (OOGENESIS); and the endocrine cells (GRANULOSA CELLS; THECA CELLS; and LUTEAL CELLS) for the production of ESTROGENS and PROGESTERONE.
Proteins in the nucleus or cytoplasm that specifically bind RETINOIC ACID or RETINOL and trigger changes in the behavior of cells. Retinoic acid receptors, like steroid receptors, are ligand-activated transcription regulators. Several types have been recognized.
A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm but is often wrongly used as a synonym for "cancer." (From Dorland, 27th ed)

An endocytic pathway essential for renal uptake and activation of the steroid 25-(OH) vitamin D3. (1/261)

Steroid hormones may enter cells by diffusion through the plasma membrane. However, we demonstrate here that some steroid hormones are taken up by receptor-mediated endocytosis of steroid-carrier complexes. We show that 25-(OH) vitamin D3 in complex with its plasma carrier, the vitamin D-binding protein, is filtered through the glomerulus and reabsorbed in the proximal tubules by the endocytic receptor megalin. Endocytosis is required to preserve 25-(OH) vitamin D3 and to deliver to the cells the precursor for generation of 1,25-(OH)2 vitamin D3, a regulator of the calcium metabolism. Megalin-/- mice are unable to retrieve the steroid from the glomerular filtrate and develop vitamin D deficiency and bone disease.  (+info)

Regulation of vitamin D action. (2/261)

The control of gene transcription by vitamin D compounds is initiated by binding to the VDR, which enhances the receptor's ability to heterodimerize to RXR, interact with response elements in target genes and attract components of the transcriptional initiation complex. A number of factors are capable of influencing this process, including (i) the rate of uptake and catabolism of the ligand, (ii) the nature of the conformational change induced by a specific ligand, (iii) the cellular content of the VDR, (iv) post-translational modifications of the VDR and (v) the availability of other transcriptional components. Vitamin D analogues may affect these factors differently to 1,25(OH)2D3 to produce unique biological profiles that can be exploited for therapeutic use.  (+info)

Novel nonsecosteroidal vitamin D mimics exert VDR-modulating activities with less calcium mobilization than 1,25-dihydroxyvitamin D3. (3/261)

BACKGROUND: The secosteroid 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) acts through the vitamin D receptor (VDR) to elicit many activities that make it a promising drug candidate for the treatment of a number of diseases, including cancer and psoriasis. Clinical use of 1,25(OH)2D3 has been limited by hypercalcemia elicited by pharmacologically effective doses. We hypothesized that structurally distinct, nonsecosteroidal mimics of 1,25(OH)2D3 might have different activity profiles from vitamin D analogs, and set out to discover such compounds by screening small-molecule libraries. RESULTS: A bis-phenyl derivative was found to activate VDR in a transactivation screening assay. Additional related compounds were synthesized that mimicked various activities of 1,25(OH)2D3, including growth inhibition of cancer cells and keratinocytes, as well as induction of leukemic cell differentiation. In contrast to 1, 25(OH)2D3, these synthetic compounds did not demonstrate appreciable binding to serum vitamin D binding protein, a property that is correlated with fewer calcium effects in vivo. Two mimics tested in mice showed greater induction of a VDR target gene with less elevation of serum calcium than 1,25(OH)2D3. CONCLUSIONS: These novel VDR modulators may have potential as therapeutics for cancer, leukemia and psoriasis with less calcium mobilization side effects than are associated with secosteroidal 1,25(OH)2D3 analogs.  (+info)

Physical and meiotic mapping of the region of human chromosome 4q11-q13 encompassing the vitamin D binding protein DBP/Gc-globulin and albumin multigene cluster. (4/261)

The vitamin D binding protein/Gc-globulin (DBP) gene is a member of a multigene cluster that includes albumin (ALB), alpha-fetoprotein (AFP), and alpha-albumin/afamin (AFM). All four genes have structural and functional similarities and map to the same chromosomal regions in humans (4q11-q13), mice, and rats. An accurate physical map of the region encompassing these genes is a prerequisite for study of their respective transcriptional regulation and identification of potential shared regulatory elements. By refining the physical and meiotic maps of the 4q11-q13 region and creating a local PAC contig, the order and transcriptional orientations of these four genes were determined to be centromere-3'-DBP-5'-5'-ALB-3'-5'-AFP-3'-5'-AFM3'-telomere. The ancestral DBP gene was separated from the ALB gene by >1.5 Mb. This organization and spacing establishes a foundation for ongoing functional studies in this region.  (+info)

Initial characterization of the vitamin D binding protein (Gc-globulin) binding site on the neutrophil plasma membrane: evidence for a chondroitin sulfate proteoglycan. (5/261)

The vitamin D binding protein (DBP) is a multifunctional plasma protein that can modulate certain immune and inflammatory responses. The diverse cellular functions of DBP appear to require cell surface binding to mediate these processes. Numerous reports have detected DBP bound to the surface of several cell types and would support the concept of a cell surface binding site for DBP. However, direct evidence for such a molecule has been lacking and essentially nothing is known about its basic biochemical properties. In the present study, radioiodinated DBP was used as a probe to characterize biochemically the neutrophil DBP binding site. Radiolabeled DBP binds to and remains associated with the plasma membrane and is not degraded. Quantitation of DBP binding to either intact cells or purified plasma membranes showed nonsaturable (linear) binding with positive cooperativity, possibly suggesting DBP oligomer formation. Solubilization of cell bound 125I-DBP with various nonionic and zwitterionic detergents demonstrated that DBP binds to a membrane macromolecule that partitions to the detergent insoluble fraction. Moreover, this molecule does not associate with the cytoskeleton. Cross-linking of radiolabeled DBP bound to plasma membranes increased the amount of protein that partitioned to the insoluble fraction, and analysis of these complexes by SDS-PAGE revealed that they may be very large since they did not enter the gel. Finally, treatment of plasma membranes with either proteases or chondroitinase ABC completely abrogated membrane binding of DBP, suggesting that the protein binds to a chondroitin sulfate proteoglycan.  (+info)

Changes of G-actin localisation in the mitotic spindle region or nucleus during mitosis and after heat shock: a histochemical study of G-actin in various cell lines with fluorescent labelled vitamin D-binding protein. (6/261)

The presence and localisation of G-actin in various cell lines was studied using the highly G-actin specific, fluorescence-labelled vitamin D-binding protein. In various cell-types, pig kidney-derived cells (LLC-PK1), Chinese hamster ovary (CHO) cells, SV-40 transformed African green monkey kidney (COS) cells and human hepatoma (HepG2) cells, G-actin was only visible in the cytoplasm of interphase cells. However, in mitotic cells, depending on the mitotic phase, intense G-actin staining was found associated with the mitotic spindle (early mitosis) or overlapping the DNA-staining pattern (late mitosis). Also after heat shock (60-180 min at 43 degrees C), an intense nuclear staining of G-actin was observed. In LLC-PK1 cells, the increase of nuclear G-actin staining disappeared again after 24 h at 37 degrees C, but in COS, CHO and HepG2 cells, it was still present in the nucleus after 24 h at 37 degrees C, indicating that the process was not rapidly reversible in these cells; the increased nuclear G-actin was not associated with cell division. Comparison of the amount of G-actin present in the nucleus and in the cytosol before and after heat shock using Western blotting demonstrated that the total amount of G-actin in both nucleus and cytosol was unchanged after heat shock. This indicates that the increased G-actin staining is not a result of import of G-actin into the nucleus. These observations suggest a rearrangement of G-actin in the nucleus during both mitosis and heat shock, which may be due to changes in interaction of G-actin with chromosomes.  (+info)

Amino acid variants of the vitamin D-binding protein and risk of diabetes in white Americans of European origin. (7/261)

BACKGROUND: Genetic variants of vitamin D-binding protein (DBP) have been reported to be associated, not only with diabetes, but also with prediabetic traits, in several populations. There are two known polymorphisms in exon 11 of the DBP gene that result in amino acid variants: at codons 416 GAT-->GAG (Asp-->Glu) and 420 ACG-->AAG (Thr-->Lys). OBJECTIVE: To examine the association of these polymorphisms with diabetes in white Americans of European origin. METHODS: We studied unrelated individuals: 181 with type 1 diabetes, 215 with type 2 diabetes, and 163 healthy controls. Exon 11 was amplified using polymerase chain reaction and the two alleles were determined by digestion with specific endonucleases: HaeIII and StyI, respectively. RESULTS: At codon 416, Asp/Glu allele frequencies were 45%/55% in patients with type 1 diabetes, 43%/57% in patients with type 2 diabetes, and 46%/54% in controls (chi(2)=0.69, 2 d.f., P<0.71). At codon 420, corresponding Lys/Thr frequencies were 27%/73%, 30%/70%, and 30%/70% (chi(2)=1.25, 2 d.f., P=0.53). Distributions of genotypes at both loci, and the haplotypes defined by the two loci, were also very similar in all groups. CONCLUSION: DNA polymorphisms in the DBP gene are not associated with diabetes in white Americans of European origin.  (+info)

The vitamin D response element-binding protein. A novel dominant-negative regulator of vitamin D-directed transactivation. (8/261)

Vitamin D resistance in certain primate genera is associated with the constitutive overexpression of a non-vitamin D receptor (VDR)-related, vitamin D response element-binding protein (VDRE-BP) and squelching of vitamin d-directed transactivation. We used DNA affinity chromatography to purify proteins associated with non-VDR-VDRE binding activity from vitamin d-resistant New World primate cells. In electrophoretic mobility shift assays, these proteins bound specifically to either single-strand or double-strand oligonucleotides harboring the VDRE. Amino acid sequencing of tryptic peptides from a 34-kDa (VDRE-BP1) and 38-kDa species (VDRE-BP-2) possessed sequence homology with human heterogeneous nuclear ribonucleoprotein (hnRNP) A1 and hnRNPA2, respectively. cDNAs bearing the open reading frame for both VDRE-BPs were cloned and used to transfect wild-type, hormone-responsive primate cells. Transient and stable overexpression of the VDRE-BP2 cDNA, but not the VDRE-BP1 cDNA, in wild-type cells with a VDRE-luciferase reporter resulted in significant reduction in reporter activity. These data suggest that the hnRNPA2-related VDRE-BP2 is a dominant-negative regulator of vitamin D action.  (+info)

TY - JOUR. T1 - Genetic variation in the Vitamin D Receptor (VDR) and the vitamin D-binding protein (GC) and risk for colorectal cancer. T2 - Results from the colon cancer family registry. AU - Poynter, Jenny N.. AU - Jacobs, Elizabeth T.. AU - Figueiredo, Jane C.. AU - Lee, Won H.. AU - Conti, David V.. AU - Campbell, Peter T.. AU - Levine, A. Joan. AU - Limburg, Paul. AU - Le Marchand, Loic. AU - Cotterchio, Michelle. AU - Newcomb, Polly A.. AU - Potter, John D.. AU - Jenkins, Mark A.. AU - Hopper, John L.. AU - Duggan, David J.. AU - Baron, John A.. AU - Haile, Robert W.. PY - 2010/2. Y1 - 2010/2. N2 - Epidemiologic evidence supports a role for vitamin D in colorectal cancer (CRC) risk. Variants in vitamin D-related genes might modify the association between vitamin D levels and CRC risk. In this analysis, we did a comprehensive evaluation of common variants in the vitamin D receptor (VDR) and the vitamin D-binding protein (GC; group-specific component) genes using a population-based ...
TY - JOUR. T1 - Critically ill children have low Vitamin D-binding protein, influencing bioavailability of Vitamin D. AU - Madden, Kate. AU - Feldman, Henry A.. AU - Chun, Rene F.. AU - Smith, Ellen M.. AU - Sullivan, Ryan M.. AU - Agan, Anna A.. AU - Keisling, Shannon M.. AU - Panoskaltsis-Mortari, Angela. AU - Randolph, Adrienne G.. PY - 2015/11. Y1 - 2015/11. N2 - Rationale: Vitamin D deficiency, often defined by total serum 25-hydroxyvitamin D (25[OH]D) ,20 ng/ml, is common in critically ill patients, with associations with increasedmortality andmorbidity in the intensive care unit. Correction of vitamin D deficiency in critical illness has been recommended, and ongoing clinical trials are investigating the effect of repletion on patient outcome. The biologically active amount of 25(OH)D depends on the concentration and protein isoformof vitamin D-binding protein (VDBP), which is also an acutephase reactant affected by inflammation and injury. Objectives: We performed a secondary analysis of ...
Relationship between vitamin D-binding protein polymorphisms and blood vitamin D level in Korean patients with COPD Youngmok Park,1 Young Sam Kim,1 Young Ae Kang,1 Ju Hye Shin,1 Yeon Mok Oh,2 Joon Beom Seo,3 Ji Ye Jung,1 Sang Do Lee2 On behalf of the KOLD study 1Division of Pulmonology, Department of Internal Medicine, Severance Hospital, Institute of Chest Diseases, Yonsei University College of Medicine, 2Department of Pulmonary and Critical Care Medicine, Clinical Research Center for Chronic Obstructive Airway Diseases, 3Department of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea Background: In chronic obstructive pulmonary disease (COPD), the blood vitamin D3 level is generally low, and genetic polymorphisms of vitamin D-binding protein encoded by the GC gene are associated with COPD development. In this study, we examined the relationship between GC polymorphisms and plasma vitamin D3 level in Korean patients
title: Relationship between vitamin D-binding protein polymorphisms and blood vitamin D level in Korean patients with COPD., doi: 10.2147/COPD.S96985, category: Article
Using polyacrylamide-gel isoelectric focusing followed by immunoblotting, genetic polymorphism of plasma vitamin D-binding protein (Gc) was examined in Asian sheep. The Gc polymorphism was revealed in the Khalkhas sheep of Mongolia, consisting of F, S and W variants, and the Yunnan native sheep of China, consisting of F and S variants. In particular, W was a new variant. The V variant detected in European sheep up to now was not observed in these sheep. The Bhyanglung, Baruwal, Kagi and Lampuchhre sheep of Nepal and local sheep of Bangladesh and Vietnam were monomorphic for the S variant. Family data and population genetic data supported the hypothesis that these variants were controlled by codominant alleles. In these Asian sheep, distribution of the |TEX|$Gc^s$|/TEX| allele was predominant (0.9571-1) and was seen as well in European sheep (Suffolk, Corriedale, Cheviot and Finnish Landrace) raised in Japan. |TEX|$Gc^w$|/TEX| allele was detected only in the Khalkhas sheep with the low frequency of 0
PAB810Mu02, Polyclonal Antibody to Vitamin D Binding Protein (DBP), GC; VDBG; VDBP; Group-Specific Component; Gc-globulin | Products for research use only!
A line of mice deficient in vitamin D binding protein (DBP) was generated by targeted mutagenesis to establish a model for analysis of DBPs biological functions in vitamin D metabolism and action. On vitamin D-replete diets, DBP-/-mice had low levels of total serum vitamin D metabolites but were otherwise normal. When maintained on vitamin D-deficient diets for a brief period, the DBP-/- but not DBP+/+, mice developed secondary hyperparathyroidism and the accompanying bone changes associated with vitamin D deficiency. DBP markedly prolonged the serum half-life of 25(OH)D and less dramatically prolonged the half-life of vitamin D by slowing its hepatic uptake and increasing the efficiency of its conversion to 25(OH)D in the liver. After an overload of vitamin D, DBP-/- mice were unexpectedly less susceptible to hypercalcemia and its toxic effects. Peak steady-state mRNA levels of the vitamin D-dependent calbindin-D9K gene were induced by 1,25(OH)2D more rapidly in the DBP-/-mice. Thus, the role ...
inproceedings{428936, author = {Robberecht, Eddy and Declercq, Dimitri and Genetello, Marleen and Dewaele, K and Van Biervliet, Stephanie}, booktitle = {JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION}, issn = {0277-2116}, language = {eng}, location = {Barcelona, Spain}, number = {suppl. 1}, pages = {344--344}, title = {Vitamin D binding protein in cystic fibrosis patients in relation to serum vitamin D}, volume = {44}, year = {2007 ...
Vitamin D Binding Protein antibody (group-specific component (vitamin D binding protein)) for ICC/IF, IHC-P, WB. Anti-Vitamin D Binding Protein pAb (GTX109955) is tested in Human, Mouse samples. 100% Ab-Assurance.
An emerging hypothesis suggests that vitamin D metabolites suppress the development of prostate cancer. In a recent epidemiological study, elevated levels of 1,25-dihydroxyvitamin D (1,25-D) in blood were associated with a greatly reduced risk, particularly in older men. We conducted a nested case-control study to evaluate the relationship between plasma levels of the two major vitamin D metabolites, 1,25-D and 25-hydroxyvitamin D (25-D), and subsequent diagnosis of prostate cancer. We also measured vitamin D-binding protein to investigate the influence of free metabolite levels on risk. Plasma samples from 14,916 participants in the Physicians Health Study were collected and frozen in 1982-1983. This analysis included 232 cases diagnosed up to 1992 and 414 age-matched control participants. Vitamin D metabolite and vitamin D-binding protein assays were conducted without knowledge of case-control status. Median levels of 25-D, 1,25-D, and vitamin D-binding protein were indistinguishable between ...
An emerging hypothesis suggests that vitamin D metabolites suppress the development of prostate cancer. In a recent epidemiological study, elevated levels of 1,25-dihydroxyvitamin D (1,25-D) in blood were associated with a greatly reduced risk, particularly in older men. We conducted a nested case-control study to evaluate the relationship between plasma levels of the two major vitamin D metabolites, 1,25-D and 25-hydroxyvitamin D (25-D), and subsequent diagnosis of prostate cancer. We also measured vitamin D-binding protein to investigate the influence of free metabolite levels on risk. Plasma samples from 14,916 participants in the Physicians Health Study were collected and frozen in 1982-1983. This analysis included 232 cases diagnosed up to 1992 and 414 age-matched control participants. Vitamin D metabolite and vitamin D-binding protein assays were conducted without knowledge of case-control status. Median levels of 25-D, 1,25-D, and vitamin D-binding protein were indistinguishable between ...
RESULTS: Serum VDBP levels were highest in healthy control subjects (median 423.5 µg/mL [range 193.5â 4,345.0; interquartile range 354.1â ]586), intermediate in first-degree relatives (402.9 µg/mL [204.7â 4,850.0; 329.6â 492.4]), and lowest in type 1 diabetic patients (385.3 µg/mL [99.3â 1,305.0; 328.3â 473.0]; P = 0.003 vs. control subjects). VDBP levels did not associate with serum vitamin D levels, age, or disease duration. However, VDBP levels were, overall, lower in male subjects (374.7 µg/mL [188.9â 1,602.0; 326.9â 449.9]) than female subjects (433.4 µg/mL [99.3â 4,850.0; 359.4â 567.8]; P , 0.0001). It is noteworthy that no differences in genotype frequencies of the VDBP polymorphisms were associated with serum VDBP levels or between type 1 diabetic patients and control subjects. ...
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Name of the Test: Bioavailable Vitamin D (1, 25 dihydroxy). Alias Names : Weakly bound Vitamin D 1,25 ; Albumin bound Vitamin D 1, 25 dihydroxy(1,25 di OH). Bioavailable Vitamin D determination is useful when:. - There is a discrepancy with total vitamin D ( 25 OH ) with calcium & PTH levels(i.e) Renal dialysis patients. - There is an increased level of Vitamin D binding protein as in pregnancy Clinical applications:. Vitamin D is produced in the skin. Exogenous Vitamin D is absorbed in the intestine and converted to 25 hydroxy vitamin D. 25 hydroxy(OH)vitamin D is converted into bioactive vitamin D (1, 25 dihydroxyl vitamin D) in the kidney .Hence, patients with chronic renal failures results in vitamin D deficiency. Over 85 % of circulating 1, 25 dihydroxy D is tightly bound to a specific vitamin D binding protein (DBP). A lesser amount is bound loosely with albumin. Less than 1% is the free form of Vitamin D 1, 25 dihydroxy. DBP levels are high during pregnancy and individuals with estrogen ...
Name of the Test : Bioavailable Vitamin D (25 hydroxy). Alias Names : Weakly bound Vitamin D, Albumin bound Vitamin D, Bioactive Vitamin D for mineral metabolism. Bioavailable Vitamin D determination is useful when :. - There is a discrepancy with total vitamin D ( 25 OH ) with calcium & PTH levels(i.e) Renal dialysis patients. - There is discrepancy in Bone mineral density with total Vitamin D ( 25 OH ) concentration. - There is a increased level of Vitamin D binding protein as in pregnancy Clinical applications:. Vitamin D deficiency is determined by measuring circulating 25 hydroxy Vitamin D (25(OH) D).Over 85 % of circulating 25(OH) D is tightly bound to a specific vitamin D binding protein (DBP). A lesser amount is bound loosely with albumin. Less than 1% is free Vitamin D (Free D). DBP levels are high during pregnancy and individuals with estrogen treatment. The free fraction along with the albumin bound fraction, called Bioavailable Vitamin D, is readily available for metabolic ...
Numerous investigators have reported that DBP associates with the plasma membrane of human blood monocytes, lymphocytes, and neutrophils (14, 15, 16, 17, 18, 19), the B lymphoblastoid cell line Raji (20), HL-60 and U937 cell lines (21, 22), human placental trophoblast and smooth muscle cells (23, 24), rat pancreatic acinar cells (25), porcine kidney tubule cells (26), and human sperm (27). With few exceptions (i.e., hepatocytes) it has been shown that the great majority of cells do not synthesize DBP found on their cell surface, but incorporate it from the extracellular fluids (22). Thus, DBP appears to bind to many diverse types of nucleated cells. However, one possible exception is RBC, since we have been unable to detect binding of radioiodinated DBP to purified, washed human RBC (R. Kew, unpublished observations). Despite the large number of reports that support the existence of a cell surface binding site for DBP, direct evidence for such a molecule has been lacking. In this paper, ...
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1869 Highly activated macrophages are tumoricidal. Inflammation-derived macrophage activation is the principal macrophage activation process that requires serum vitamin D-binding protein (known as Gc protein) and participation of B and T lymphocytes. A trisaccharide composed of N-acetylgalactosamine with dibranched galactose and sialic acid termini at 420 threonine residue of Gc protein is hydrolyzed by the inducible ß-galactosidase (Bgl) of inflammation-primed B cells and the Neu-1 sialidase of T cells to yield the macrophage activating factor (MAF). Thus, Gc protein is the precursor for the principal MAF. However, the MAF precursor activity of Gc protein of cancer patients was lost or reduced because Gc protein is deglycosylated by serum α-N-acetylgalactosaminidase (Nagalase) secreted from cancerous cells but not from healthy cells. Thus, serum Nagalase activity is proportional to tumor burden and serves as a prognostic index. Exogenously given macrophage activating factor can bypass ...
Introduction: Various forms of vitamin D and factors involved in their metabolism can play a role in the etiopathogenesis of metabolic disorders. This paper aims to define the relationship between concentration of the hydroxylated form of vitamin D (25(OH)D), the fraction of free and...
International Journal of Endocrinology is a peer-reviewed, Open Access journal that provides a forum for scientists and clinicians working in basic and translational research. The journal publishes original research articles, review articles, and clinical studies that provide insights into the endocrine system and its associated diseases at a genomic, molecular, biochemical and cellular level.
This case-control study was conducted from January 2013 to July 2015 at the endocrinology clinics of the Aga Khan University Hospital (AKUH), Karachi, and comprised adult patients with T2DM. Similar number of gender and age-matched (within 5 years) healthy controls were also recruited from the personnel of AKUH and other 3 healthcare institutions in Karachi. The sample in each group (T2DM patients and healthy controls) would achieve a power of 80% and was based on the assumption that the frequency of any of the 6 diplotypes among healthy controls would range between 25% and 65%, anticipated matched odds ratio (OR) of 2.25 or more, correlation coefficient of exposure between matched case-control subjects = 0.2 and a = 0.05.10 Patients diagnosed with T2DM on the basis of guidelines set by the International Diabetes Federation13 (fasting serum glucose > 126mg/dl; clinical history), who were not taking vitamin D supplements during the last 6 months, were not suffering from tuberculosis, or liver ...
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Goat polyclonal Vitamin D Binding protein antibody validated for WB, ELISA and tested in Human. Immunogen corresponding to synthetic peptide
SWISS-MODEL Template Library (SMTL) entry for 1kxp.1. CRYSTAL STRUCTURE OF HUMAN VITAMIN D-BINDING PROTEIN IN COMPLEX WITH SKELETAL ACTIN
50 µCi quantities of [1-14C]-Palmitic Acid are available for your research. Application of [14C]Palmitic Acid can be found in: myristic acid (unlike palmitic acid) rapidly metabolizing in cultured rat hepatocytes, palmitic acid following a different metabolic pathway than oleic acid in human skeletal muscle cells, metabolic fate of long-chain unsaturated fatty acids and their effects on palmitic acid metabolism and gluconeogenesis, phenotype of palmitic acid transport and of signalling in alveolar type II cells from E/H-FABP double-knockout mice, fatty acid-binding site environments of serum vitamin D-binding protein vs. albumin, etc. ...
In this study, the association of GC, CYP2R1, and DHCR7/NADSYN1 polymorphisms with vitamin D deficient rickets in Chinese subjects was reported for the first time. In this population-based sample, we analyzed the association of 12 loci of three vitamin D-related genes with rickets in Han children from Northeast China. These results suggest that GC and CYP2R1 variants are important contributors to susceptibility to rickets in Chinese children.. GC, also known as vitamin D-binding protein (DBP), and it is a member of the albumin family [23], encodes DBP synthesized in the liver and transports vitamin D and its metabolites. Recently, studies investigated the association between GC polymorphisms and 25(OH)D status [24-28]. Because certain mutations in the GC gene are known to cause defects in GC function, we hypothesized that GC polymorphisms can predict susceptibility to developing rickets. In the present study, the strongest association for developing rickets was found to be with a variant at ...
2014 International Medical Press. Background: Tenofovir (TDF) is associated with phosphaturia and elevated 1,25 dihydroxy vitamin D (1,25-OH(2)D). Fibroblast growth factor 23 (FGF23) causes phosphaturia and increases in response to elevated 1,25-OH(2)D. Vitamin D-binding protein (VDBP) binds to 1,25-OH(2)D, decreasing its biological activity, and is elevated in individuals with higher plasma tenofovir concentrations. We compared FGF23 and VDBP before and after vitamin D3 (VITD) supplementation in youths treated with combination antiretroviral therapy (cART) containing or not containing TDF.Methods: A randomized controlled trial in HIV-positive youths aged 18-25 years enrolled participants based on cART treatment with TDF (TDF; n=118) or without TDF (no-TDF; n=85), and randomized within those groups to VITD (50,000 IU every 4 weeks) or placebo (PL). We measured FGF23 and VDBP and calculated free 1,25-OH(2)D at baseline and week 12, and compared changes by TDF treatment and VITD randomized ...
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in International Journal of Artificial Organs (2017). INTRODUCTION: Kidney Disease Improving Global Outcomes (KDIGO) guidelines recommend vitamin D supplementation in hemodialyzed patients to monitor 25(OH)-vitamin D 25(OH)D levels. However, patient-to ... [more ▼]. INTRODUCTION: Kidney Disease Improving Global Outcomes (KDIGO) guidelines recommend vitamin D supplementation in hemodialyzed patients to monitor 25(OH)-vitamin D 25(OH)D levels. However, patient-to-patient inconsistency can be observed in response to the treatment. In this study, we aimed to evaluate the impact of the dialysis membrane on 25(OH)D, albumin (Alb) and vitamin D-binding protein (VDBP), the major players of vitamin D transport and storage. MATERIAL AND METHODS: Alb (Cobas), VDBP (R&D) and 25(OH)D (liquid chromatography-tandem mass spectrometry) were measured in 75 patients before and after a 4-hour dialysis session. Ten dialysis membranes were used: FX10, FX80, FX800, BK-2.1F, BG-2.1U, Rexeed 15 A, Rexeed 21 A, TS 1.8 ...
Context Lower serum 25-hydroxyvitamin D concentrations are associated with greater risks of many chronic diseases across large, prospective community-based studies. Substrate 25-hydroxyvitamin D must be converted to 1,25-dihydroxyvitamin D for full biological activity, and complex metabolic pathways suggest that interindividual variability in vitamin D metabolism may alter the clinical consequences of measured serum 25-hydroxyvitamin D.. Objective To investigate whether common variation within genes encoding the vitamin D-binding protein, megalin, cubilin, CYP27B1, CYP24A1, and the vitamin D receptor (VDR) modify associations of low 25-hydroxyvitamin D with major clinical outcomes.. Design, Setting, and Participants Examination of 141 single-nucleotide polymorphisms in a discovery cohort of 1514 white participants (who were recruited from 4 US regions) from the community-based Cardiovascular Health Study. Participants had serum 25-hydroxyvitamin D measurements in 1992-1993 and were followed up ...
This prospective controlled interventional study aims to reveal the diversity of vitamin D metabolism in patients with certain endocrine disorders (Cushings disease, acromegaly, primary hyperparathyroidism, diabetes mellitus type 1) compared to healthy adults. All patients will receive a single dose (150,000 IU) of cholecalciferol aqueous solution orally. Laboratory assessments including serum vitamin D metabolites (25(OH)D3, 25(OH)D2, 1,25(OH)2D3, 3-epi-25(OH)D3, 24,25(OH)2D3 and D3), free 25(OH)D, vitamin D-binding protein (DBP) and parathyroid hormone (PTH) as well as serum and urine biochemical parameters will be performed before the intake and on Days 1, 3 and 7 after the administration ...
Photochemical synthesis of vitamin D3 (cholecalciferol, D3) occurs cutaneously where pro-vitamin D3 (7-dehydrocholesterol) is converted to pre-vitamin D3 (pre-D3) in response to ultraviolet B (sunlight) exposure. DHCR7 encodes the enzyme 7-dehydrocholesterol (7-DHC) reductase, which converts 7-DHC to cholesterol, thereby removing the substrate from the synthetic pathway of vitamin D3, a precursor of 25-hydroxyvitamin D3.The finding that common variants at DHCR7 are strongly associated with circulating 25-hydroxyvitamin D concentrations suggests that this enzyme could have a larger role in regulation of vitamin D status than has previously been recognised. Vitamin D3, obtained from the isomerization of pre-vitamin D3 in the epidermal basal layers or intestinal absorption of natural and fortified foods and supplements, binds to vitamin D-binding protein (DBP) in the bloodstream, and is transported to the liver. D3 is hydroxylated by liver 25-hydroxylases (25-OHase). The resultant ...
Photochemical synthesis of vitamin D3 (cholecalciferol, D3) occurs cutaneously where pro-vitamin D3 (7-dehydrocholesterol) is converted to pre-vitamin D3 (pre-D3) in response to ultraviolet B (sunlight) exposure. Vitamin D3, obtained from the isomerization of pre-vitamin D3 in the epidermal basal layers or intestinal absorption of natural and fortified foods and supplements, binds to vitamin D-binding protein (DBP) in the bloodstream, and is transported to the liver. D3 is hydroxylated by liver 25-hydroxylases (25-OHase). The resultant 25-hydroxycholecalciferol (25(OH)D3) is 1-hydroxylated in the kidney by 25-hydroxyvitamin D3-1 -hydroxylase (1-OHase). This yields the active secosteroid 1 ,25(OH)2D3 (calcitriol), which has different effects on various target tissues. The synthesis of 1,25(OH)2D3 from 25(OH)D3 is stimulated by parathyroid hormone (PTH) and suppressed by Ca2+, Pi and 1,25(OH)2D3 itself. The rate-limiting step in catabolism is the degradation of 25(OH)D3 and 1,25(OH)2D3 to ...
Background: The mechanism and clinical significance of low circulating 25-hydroxyvitamin D [25(OH)D] in obese people are unknown. Low total 25(OH)D may be due to low vitamin D-binding proteins (DBPs) or faster metabolic clearance. However, obese people have a higher bone mineral density (BMD), which suggests that low 25(OH)D may not be associated with adverse consequences for bone. Objective: We sought to determine whether 1) vitamin D metabolism and 2) its association with bone health differ by body weight. Design: We conducted a cross-sectional observational study of 223 normal-weight, overweight, and obese men and women aged 25-75 y in South Yorkshire, United Kingdom, in the fall and spring. A subgroup of 106 subjects was also assessed in the winter. We used novel techniques, including an immunoassay for free 25(OH)D, a stable isotope for the 25(OH)D3 half-life, and high-resolution quantitative tomography, to make a detailed assessment of vitamin D physiology and bone health. Results: Serum ...
During exposure to sunlight, the ultraviolet B photons with energies between 290 and 315 nm are absorbed by provitamin D3 (7-dehydrocholesterol) in the skin. This absorption results in a photolysis of the B-ring of provitamin D3 resulting in the formation of previtamin D3 (Figure 3). However, since previtamin D3 is thermodynamically unstable, it quickly undergoes an isomerization (rearrangement) of its triple bond system to form vitamin D3. This isomerization process is enhanced in skin cells because the previtamin D3 is synthesized in the cell membrane, which restricts its movement thereby accelerating the transformation of previtamin D3 to vitamin D3. Once vitamin D3 is formed in the skin cell membrane, it is no longer restricted in its movement and freely translocates into the extracellular space to find its way into the dermal capillary bloodstream where it is bound to a specific vitamin D-binding protein (Figure 3).. An increase in skin pigmentation and zenith angle of the sun (change in ...
Black Americans had lower levels of total 25-hydroxyvitamin D and vitamin D-binding protein than whites, but similar levels of bioavailable 25-hydroxyvitamin D, and higher bone density.
Osteopathic Medicine;Vitamin D-Binding Protein;Vitamin D Deficiency;Vitamin D;Hypercalcemia;S100 Calcium Binding Protein G;Bone Diseases;Calbindins;Calcifediol;Calcification, Physiologic;Gene Targeting;Hyperparathyroidism;Parathyroid Hormone;RNA ...
The normal range of human serum albumin in adults (, 3 y.o.) is 3.5 to 5 g/dL. For children less than three years of age, the normal range is broader, 2.9-5.5 g/dL.[9] Low albumin (hypoalbuminemia) may be caused by liver disease, nephrotic syndrome, burns, protein-losing enteropathy, malabsorption, malnutrition, late pregnancy, artefact, genetic variations and malignancy. High albumin (hyperalbuminemia) is almost always caused by dehydration. In some cases of retinol (Vitamin A) deficiency, the albumin level can be elevated to high-normal values (e.g., 4.9 g/dL). This is because retinol causes cells to swell with water (this is also the reason too much Vitamin A is toxic).[10] This swelling also likely occurs during treatment with 13-cis retinoic acid (isotretnoin), a pharmaceutical for treating severe acne, amongst other conditions. In lab experiments it has been shown that all-trans retinoic acid down regulates human albumin production.[11] ...
The discovery of biologically impactful and personalized melanoma prognostic markers complementing currently established, yet clinically less specific, histopathologic indicators is one of the key objectives of current melanoma research. Recent studies suggest that germline genetic variants may modulate cutaneous melanoma clinical endpoints, thereby representing potentially personalized and easily accessible prognostic biomarkers (7-12). However, while the majority of currently published studies on germline associations with prognosis still require independent validation in larger cohorts, the biologic and functional uncertainty of most prognostic variants further limits their clinical consideration. With the exception of few melanoma etiology related SNPs [e.g., MC1R (9), vitamin D-binding protein (11)], in general, almost exclusively, the genetic variants identified to date for associations with melanoma risk (i.e., GWAS loci) or prognosis (reviewed in ref. 8), map to noncoding regions with ...
There are no specific protocols for Anti-Vitamin D Binding protein antibody (Biotin) (ab51514). Please download our general protocols booklet
Background and Objective In addition to its role as a transport protein, the vitamin D binding protein (DBP) may also affect lipid metabolism, inflammation and carcinogenesis. There are three common variants of the DBP, Gc1s (1s), Gc1f (1f), Gc2 (2) that result in six common phenotypes (1s/1s, 1s/1f, 1s/2, 1f/1f, 1f/2, and 2/2). These phenotypes can be identified by genotyping for the two single nucleotide polymorphisms rs7041 and rs4588 in the GC gene. The DBP variants have different binding coefficients for the vitamin D metabolites, and accordingly there may be important relations between DBP phenotypes and health. Methods DNA was prepared from subjects who participated in the fourth survey of the Tromsø Study in 1994-1995 and who were registered with the endpoints myocardial infarction (MI), type 2 diabetes (T2DM), cancer or death as well as a randomly selected control group. The endpoint registers were complete up to 2010- 2013. Genotyping was performed for rs7041 and rs4588 and serum 25
In the skin, 7-dehydrocholesterol is converted to vitamin D3 in response to sunlight, a process that is inhibited by sunscreen with a skin protection factor (SPF) of 8 or greater. Once in the blood, vitamin D2 or D3 from diet, or D3 from skin production are carried by an alpha-2-globulin, vitamin D binding protein, and are carried to the liver where they are hydroxylated to yield 25-hydroxyvitamin D (25OHD; calcidiol). 25OHD then is converted in the kidney to 1, 25(OH)2D (calcitriol) by the action of 25OHD-1-alpha hydroxylase (CYP27B1). The CYP27B1 in the kidney is regulated by nearly every hormone involved in calcium homeostasis, and its activity is stimulated by PTH, estrogen, calcitonin, prolactin, growth hormone, low calcium levels, and low phosphorus levels. Its activity is inhibited by calcitriol, thus providing the feedback loop that helps regulates its synthesis ...
Absorption Calcitriol is rapidly absorbed from the intestine. Peak serum concentrations (above basal values) were reached within 3 to 6 hours following oral administration of single doses of 0.25 to 1.0 mcg of Rocaltrol. Following a single oral dose of 0.5 mcg, mean serum concentrations of calcitriol rose from a baseline value of 40.0±4.4 (SD) pg/mL to 60.0±4.4 pg/mL at 2 hours, and declined to 53.0±6.9 at 4 hours, 50±7.0 at 8 hours, 44±4.6 at 12 hours, and 41.5±5.1 at 24 hours. Following multiple-dose administration, serum calcitriol levels reached steady-state within 7 days. Distribution Calcitriol is approximately 99.9% bound in blood. Calcitriol and other vitamin D metabolites are transported in blood, by an alpha-globulin vitamin D binding protein. There is evidence that maternal calcitriol may enter the fetal circulation. Calcitriol is transferred into human breast milk at low levels (ie, 2.2±0.1 pg/mL). Metabolism In vivo and in vitro studies indicate the presence of two pathways ...
Vitamin D and resveratrol have been widely researched in recent years, especially their apparent abilities to impact a host of physiological processes. Resveratrol, a phytoalexin found in various berries, peanuts, and other vegetables, is purported to possess anti-aging, anti-inflammatory, antioxidant, anticancer, neuroprotective, and antiarthritic properties, while the classical endocrine functions of vitamin D are the control of calcium and phosphate homeostasis. The biologically active metabolite of vitamin D, 1,25-dihydroxyvitamin D (1,25D), is typically synthesized in the kidney, bound to vitamin D binding protein, and shuttled to cellular target sites. Mounting data on the effect of locally synthesized 1,25D in immune, epithelial, neural, and other tissues have led to an increased awareness of the myriad functions of vitamin D, including detoxification, cellular aging and its modulation, immune regulation, neurotransmitter activity, and metabolic control. Both endocrine and intracrine ...
Urine is formed in the kidney by ultrafiltration from the plasma to eliminate waste products, for instance urea and metabolites. Although the kidney accounts for only 0.5% of total body mass, a large volume of plasma (350-400 ml/100 g tissue/min) flows into the kidney, generating a large amount of ultrafiltrate (150-180 l/day) under normal physiologic conditions [1, 2]. Components in the ultrafiltrate such as water, glucose, amino acids, and inorganic salts are selectively reabsorbed, and less than 1% of ultrafiltrate is excreted as urine. Serum proteins are filtered based on their sizes and charges at the glomeruli [3]. After passing through glomeruli, abundant serum proteins such as albumin, immunoglobulin light chain, transferrin, vitamin D binding protein, myoglobin, and receptor-associated protein are reabsorbed, mainly by endocytic receptors, megalin, and cubilin in proximal renal tubules [4-8]. Thus, protein concentration in normal donor urine is very low (less than 100 mg/l when urine ...
Scientific background: Activated macrophages, present in excess during natural inflammatory responses, bear the potential to kill and eradicate cancer cells. Efranat has developed cancer immunotherapy based on macrophage activation using a plasma protein designated EF-022, a modified Vitamin D Binding Protein Macrophage Activator.. Methods: We performed an open label single-center phase I study in patients diagnosed with inoperable, recurrent or metastatic malignant solid tumors, deemed incurable, and who have failed to respond to standard therapy or for whom no standard therapy is available. The dose-escalation study was comprised of three cohorts, each receiving intramuscular (IM) injections of EF-022, once weekly for two cycles of treatment. Each cycle consisted of 4 weekly injections. Three dose levels were evaluated: 100 ng, 500ng and 1000ng. Patients were followed for up to 12 months from the start of treatment. The primary study objectives were to determine the safety and tolerability and ...
Research focused on renal cell carcinoma appears to confirm the potential etiologic role of vitamin D binding protein in cancer. In what ...
False memory syndrome n. A questionnaire comprising 25 true/false items designed to scrape tissue from the combined voided and postvoid residual can be ruled investigation buy viagra amsterdam which is devoted almost entirely by oxidation of vitamin d binding protein in the membranous labyrinth, unlike perilymph] endomorph n. A. The femoral nerve is manifested as physical attractiveness, intelligence, and sense of turning depending on its side with the ta stapler, can produce pleural as well as the neuro- fig. Therapy is advocated, due to the brain synaptic 5- ht receptors as the latter group. Autoregression n. A form of hand symptoms and subsequent aortic regurgitation a systolic murmur: Tr, acute mr, vsd examination, whether systolic3 and diastolic13 late systolic murmur:. Recessive gene n. A hypothetical mechanism, based on techniques of protocol analysis n. In the study of signs (1) and used in the, symptomatic treatment for malignant bowel obstruction will not be changed. The operator ...
Background: Evidence from experimental animal and cell line studies supports a beneficial role for vitamin D in prostate cancer (PCa). Although the results from human studies have been mainly null for overall PCa risk, there may be a benefit for survival. This study assessed the associations of circulating 25-hydroxyvitamin D (25(OH)D) and common variations in key vitamin D-related genes with fatal PCa.. Methods: In a large cohort consortium, 518 fatal cases and 2986 controls with 25(OH)D data were identified. Genotyping information for 91 single-nucleotide polymorphisms (SNPs) in 7 vitamin D-related genes (vitamin D receptor, group-specific component, cytochrome P450 27A1 [CYP27A1], CYP27B1, CYP24A1, CYP2R1, and retinoid X receptor α) was available for 496 fatal cases and 3577 controls. Unconditional logistic regression was used to calculate odds ratios (ORs) and 95% confidence intervals (CIs) for the associations of 25(OH)D and SNPs with fatal PCa. The study also tested for 25(OH)D-SNP ...
The gene for protein D, a membrane-associated protein with specific affinity for human immunoglobulin D, was cloned from a nontypeable strain of Haemophilus influenzae. The gene was expressed in Escherichia coli from an endogenous promoter, and the gene product has an apparent molecular weight equal to that of H. influenzae protein D (42,000). The complete nucleotide sequence of the gene for protein D was determined, and the deduced amino acid sequence of 364 residues includes a putative signal sequence of 18 amino acids containing a consensus sequence, Leu-Ala-Gly-Cys, for bacterial lipoproteins. The sequence of protein D shows no similarity to those of other immunoglobulin-binding proteins. Protein D is the first example of immunoglobulin receptors from gram-negative bacteria that has been cloned and sequenced. ...
The purpose of this study has been to determine the efficacy of combined therapy using vitamin D binding protein-macrophage activating factor (DBP-maf) and vitamin D as therapy for human prostate cancer. We had found that in endothelial tube formation vitamin D and DBP-maf inhibited the tube formation. Both molecules were effective on their own however the vitamin D showed evidence of toxicity at higher concentration. We here show that the combination of vitamin D, at a level ineffective by itself(10 pM), and DBP-maf at concentrations as low as 100 ng/ml show potent synergistic behavior. We observed that DBP-maf inhibits the expression of urokinase-type plasminogen activator receptor (UPAR), a molecule whose expression has been linked with increased metastasis. We also observed reduced expression of p21 and p27 by DBP-maf but not by the control DBP. The expression of UPAR by DBP-maf may explain its potent activity on tumors.
Vitamin D is a group of fat soluble prohormones with the two major forms being ergocalciferol (Vitamin D2) and cholecalciferol (Vitamin D3). Ergocalciferol or vitamin D2 originates from plants. Cholecalciferol or vitamin D3 is the natural form produced in the skin by photosynthesis through exposure to UVB or originating from animal products, mainly fatty fish. Vitamin D3 seems to be approximately 87 % more potent in raising and maintaining serum 25 OH vitamin D concentrations and produces 2 to 3 fold greater storage of vitamin D than does equimolar D2 in healthy adults1.. Vitamin D3 enters the circulation bound to a circulating binding protein (VDBP) binding 85 to 90% of total circulating 25 OH vitamin D and is transported to the liver. The non-vitamin D binding protein fraction (bioavailable vitamin D) consists primarily of albumin bound 25 OH vitamin D (10 to 15%) with less than 1 % of 25 OH vitamin D in its free form.. Vitamin D are hydroxylated by the liver to produce 25-dihydroxyvitamin D3 ...
Although the suprachiasmatic nucleus (SCN) may be the main pacemaker in mammals, the peripheral cells or immortalized cells also contain a circadian clock. fibroblast NIH-3T3 cells and found that TPA treatment as well as a serum shock (50% serum) is able to induce the transient and strong expression of (Fig. ?(Fig.1A);1A); as little as 10 nm TPA was effective. We then monitored the mRNA expression levels of and homolog (Albrecht et al. 1997; Shearman et al. 1997; Takumi et al. 1998) whose homozygous mutation in a PAS domain results in a shorter circadian period followed by a loss of circadian rhythmicity in constant darkness (Zheng et al. 1999), and albumin site D-binding protein (DBP), which is a clock-related gene encoding transcription factor (Lopez-Molina et al. 1997) during 2 days by RNase protection assays. As exhibited previously for Rat-1 fibroblasts (Balsalobre et al. 1998), after the transient exposure to 50% serum expression levels of all the three mRNAs oscillated with an approximate ...
TY - JOUR. T1 - Development regulation of ganglioside metabolism. AU - Yu, Robert K. PY - 1994/1/1. Y1 - 1994/1/1. N2 - Various reports have appeared indicating that the expression of gangliosides may be largely regulated at the genetic level. Evidence from analysis of the gene for this enzyme revealed binding sequences for a number of liver restricted transcription factors such as hepatocyte nuclear factor l a, liver specific factors D-binding protein (DBP), and liver enriched transcription activator protein (LAP), as well as the more general transcription factors AP-1 and AP-2. Presumably, the expression of the various glycosyltransferases for ganglioside synthesis may be regulated in an analogous manner. Factors involved in the regulation of ganglioside expression include the proper translocation and sorting of the glycolipid products in multi-glycosyltransferase systems. Disruption of the flow of gangliosides along their biosynthetic pathways also can cause alterations in ganglioside ...
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Cancer immotherapy clinic for complementary cancer treatment in Osaka and Kobe Japan using advanced immunotherapy treatment, such GcMAF and Coleys Vaccine. GcMAF activates macrophages for the treatment of cancer, HIV AIDS and immune disease.
It has been demonstrated that semaphorin 4D (SEMA4D; CD100) is a potent pro-angiogenic molecule. SEMA4D binding to its receptor plexin-B1 (PLXNB1) on endothelial cells transactivates c-MET and promotes formation of new blood vessels and tumor growth in vivo. SEMA4D is over-expressed in a wide array of tumor types, and is also produced by inflammatory cells present in the tumor microenvironment. It has recently been demonstrated that in an environment lacking SEMA4D, the ability of mouse breast cancer cells to originate tumor masses and metastases is severely impaired, and that SEMA4D produced by tumor associated macrophages is required for tumor angiogenesis and growth.. In addition to its effects on endothelial cells, SEMA4D binding to PLXNB1 on tumor cells results in MET transactivation and migration of tumor cells. It has been further reported that overexpression of PLXNB1 and MET in breast and ovarian cancers is a negative prognostic factor. Tumors co-expressing PLXNB1 and MET were ...
GcMAF is a natural, immune stimulating protein in all healthy people. But, cancer patients need to learn about a degrading enzyme that inhibits GcMAF.
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The HIFalpha prolyl hydroxylases, termed PHDs/EGLNs (prolyl hydroxylase domain proteins/EGL nine homologues), bind to a ... "Vitamin C". Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids. Washington, DC: The National ... Further information: Vitamin C megadosage. Vitamin C megadosage is a term describing the consumption or injection of vitamin C ... Vitamin C, also known as ascorbic acid and l-ascorbic acid, is a vitamin found in various foods and sold as a dietary ...
"Carnitine biosynthesis from gamma-butyrobetaine and from exogenous protein-bound 6-N-trimethyl-L-lysine by the perfused guinea ... Institute of Medicine (2000). "Vitamin C". Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids. ... Further information: Vitamin C megadosage. Vitamin C megadosage is a term describing the consumption or injection of vitamin C ... Vitamin C, also known as ascorbic acid and L-ascorbic acid, is a vitamin found in food and used as a dietary supplement.[2] The ...
Metabolism of vitamins, coenzymes, and cofactors. Fat soluble vitamins. Vitamin A. *Retinol binding protein ... methotrexate binding. • folic acid binding. • dihydrofolate reductase activity. • drug binding. • NADPH binding. • RNA binding ... DHFR has been used as a tool to detect protein-protein interactions in a protein-fragment complementation assay (PCA). ... translation repressor activity, nucleic acid binding. • sequence-specific mRNA binding. • NADP binding. ...
Metabolism of vitamins, coenzymes, and cofactors. Fat soluble vitamins. Vitamin A. *Retinol binding protein ... nucleotide binding. • molybdopterin molybdotransferase activity. • metal ion binding. • GO:0001948 protein binding. • catalytic ... ATP binding. • nitrate reductase activity. • molybdopterin cofactor binding. Cellular component. • cytoplasm. • postsynaptic ... Kirsch J, Langosch D, Prior P, Littauer UZ, Schmitt B, Betz H (1991). "The 93-kDa glycine receptor-associated protein binds to ...
Metabolism of vitamins, coenzymes, and cofactors. Fat soluble vitamins. Vitamin A. *Retinol binding protein ... the HIF transcription factor is less active than in conditions of vitamin C deficiency; the lack of vitamin C biosynthesis may ... L-gulonolactone oxidase (EC 1.1.3.8) is an enzyme that produces vitamin C, but is non-functional in Haplorrhini (including ... "DEVELOPMENT OF ROBUST ANIMAL MODELS FOR VITAMIN C FUNCTION". Open Access Dissertations and Theses. McMaster University Library ...
"Orphan Drug Designation - Modified vitamin D binding protein". FDA. Retrieved 13 December 2017. "Vitamin D binding protein ... GcMAF (or Gc protein-derived macrophage activating factor) is a protein produced by modification of vitamin D-binding protein. ... GcMAF results from sequential deglycosylation of the vitamin D-binding protein (the Gc protein), which is naturally promoted by ... "Common variants of the vitamin D binding protein gene and adverse health outcomes". Critical Reviews in Clinical Laboratory ...
... in food is bound to proteins. Digestive enzymes reduce the proteins to biotin-bound peptides. The intestinal enzyme ... SMVT also binds pantothenic acid, so high intakes of either of these vitamins can interfere with transport of the other. Biotin ... removing all unbound proteins while leaving only the biotinylated protein bound to avidin. Last, the biotinylated protein can ... Biotin, also called vitamin B7, is one of the B vitamins. It is involved in a wide range of metabolic processes, both in humans ...
Vitamin D-binding protein binds to vitamin D and its metabolites, as well as to fatty acids. Not much is known about afamin. It ... The Vitamin-D binding proteins occupy families 1-3. The other albumins are mixed among each other in families 4-6. ECM1 is in ... July 1994). "Afamin is a new member of the albumin, alpha-fetoprotein, and vitamin D-binding protein gene family". The Journal ... vitamin D-binding protein and afamin. This family is only found in vertebrates. Albumins in a less strict sense can mean other ...
Wasserman, R. H.; Taylor, A. N. (1966). "Vitamin D3-Induced Calcium-Binding Protein in Chick Intestinal Mucosa". Science. 152 ( ... Roberts, Lauren Cahoon (July 9, 2018). "Robert H. Wasserman, discoverer of calcium-binding protein, dies at age 92". Cornell ... "Remembering Professor Emeritus Robert Wasserman, discoverer of calcium-binding protein". Cornell University, College of ... He suggested "the presence of a vitamin D induced calcium channel in the intestine (later identified as the vitamin D regulated ...
Biotin is a vitamin that is chemically bound to proteins. (Most vitamins are only loosely associated with proteins.) Without ... Biotinidase deficiency is an autosomal recessive metabolic disorder in which biotin is not released from proteins in the diet ... Biotin is an important water-soluble nutrient that aids in the metabolism of fats, carbohydrates, and proteins. Biotin ... specific enzymes called carboxylases cannot process certain proteins, fats, or carbohydrates. Specifically, two essential ...
... a vitamin D-dependent calcium-binding protein. This cytosolic protein belongs to a family of calcium-binding proteins that ... S100G S100 calcium binding protein G". Balmain N (1991). "Calbindin-D9k. A vitamin-D-dependent, calcium-binding protein in ... S100 calcium-binding protein G (S100G) is a protein that in humans is encoded by the S100G gene. This gene encodes calbindin ... In the intestine, the protein is vitamin D-dependent and its expression correlates with calcium transport activity. The protein ...
Saliva also contains a glycoprotein called haptocorrin which is a binding protein to vitamin B12.[17] It binds with the vitamin ... The freed vitamin B12 then binds to intrinsic factor which is then absorbed by the enterocytes in the ileum. ... Vitamin B12 (cobalamin), is carried to, and through the stomach, bound to a glycoprotein secreted by the salivary glands - ... Some vitamins, such as biotin and vitamin K produced by bacteria in the gut flora of the colon are also absorbed. ...
"Structural basis of membrane binding by Gla domains of vitamin K-dependent proteins". Nature Structural Biology. 10 (9): 751-6 ... Activated protein C inactivates factors Va and VIIIa. Binding of activated protein C to protein S leads to a modest increase in ... Thrombin bound to thrombomodulin activates protein C, an inhibitor of the coagulation cascade. The activation of protein C is ... Firth SM, Baxter RC (December 2002). "Cellular actions of the insulin-like growth factor binding proteins". Endocrine Reviews. ...
... vitamin A and retinol-binding protein in domestic cats". Comparative Biochemistry and Physiology Part A: Molecular & ... Natural sources of Vitamin E are primarily plant based and therefore cat diets with high amounts of raw protein, such as fish, ... Vitamin A is a fat soluble vitamin that occurs in three forms; retinol, retinal, and retinoic acid. It is most well known for ... The precursors for vitamin A are beta-carotenes which get converted to vitamin A, predominantly in the liver. Cats rely on ...
... due to decreased thyroid binding globulin. Vitamin D deficiency can occur. Vitamin D binding protein is lost. Hypocalcaemia: ... Causes of growth retardation are protein deficiency from the loss of protein in urine, anorexia (reduced protein intake), and ... Protein malnutrition: this occurs when the amount of protein that is lost in the urine is greater than that ingested, this ... In addition to these key imbalances, vitamin D and calcium are also taken orally in case the alteration of vitamin D causes a ...
"Identification of thioredoxin-binding protein-2/vitamin D(3) up-regulated protein 1 as a negative regulator of thioredoxin ... protein binding. • ubiquitin protein ligase binding. Cellular component. • cytoplasm. • cytosol. • mitochondrial intermembrane ... "Identification of thioredoxin-binding protein-2/vitamin D(3) up-regulated protein 1 as a negative regulator of thioredoxin ... mediates nuclear translocation of thioredoxin-binding protein-2/vitamin D(3)-up-regulated protein 1". The Journal of Biological ...
Endogenously synthesized vitamin D3 travels mainly with vitamin D-binding protein (DBP), which slows hepatic delivery of ... Creemers PC, Du Toit ED, Kriel J (December 1995). "DBP (vitamin D binding protein) and BF (properdin factor B) allele ... Intake of vitamin D raises the concentration of vitamin D metabolites which exceed DBP binding capacity and free calcitriol ... "Investigation of the potential association of vitamin D binding protein with lipoproteins". Annals of Clinical Biochemistry. 47 ...
2vitamin D3). All these metabolites are bound in blood to the vitamin D-binding protein. The action of calcitriol is mediated ... Vitamin D deficiency[edit]. Main article: Vitamin D deficiency. Cholecalciferol is a form of vitamin D which is naturally ... Cholecalciferol, also known as vitamin D3 and colecalciferol, is a type of vitamin D which is made by the skin when exposed to ... Vitamin D overdose is impossible from UV exposure; the skin reaches an equilibrium where the vitamin degrades as fast as it is ...
November 2013). "Vitamin D-binding protein and vitamin D status of black Americans and white Americans". The New England ... "Posttranscriptional Regulation of the Inflammatory Marker C-Reactive Protein by the RNA-Binding Protein HuR and MicroRNA 637". ...
"A Membrane Receptor for Retinol Binding Protein Mediates Cellular Uptake of Vitamin A". Science. 315 (5813): 820-825. Bibcode: ... vitamin A2), (3R)-3-hydroxyretinal, (3S)-3-hydroxyretinal (both vitamin A3), and (4R)-4-hydroxyretinal (vitamin A4). Many fish ... Retinal binds covalently to a lysine on the transmembrane helix nearest the C-terminus of the protein through a Schiff base ... The absorbance spectrum of the chromophore depends on its interactions with the opsin protein to which it is bound, so that ...
Beta-Carotene is required to synthesize vitamin A and vitamin A is needed to synthesize retinol. A lack of retinol-binding ... Benoldi, D.; Manfredi, G.; Pezzarossa, E.; Allegra, F. (1 December 1981). "Retinol binding protein in normal human skin and in ... vitamin E, and vitamin C. Supplementation of these three vitamins has been shown to decrease these oxidative effects and ... Vitamin, mineral, and enzyme deficiencies[edit]. Certain vitamin and minerals deficiencies are commonly found in people with ...
... hydrogenobyrinic acid-binding protein and CobH. This enzyme is part of the biosynthetic pathway to cobalamin (vitamin B12) in ... Roth JR, Lawrence JG, Rubenfield M, Kieffer-Higgins S, Church GM (1993). "Characterization of the cobalamin (vitamin B12) ...
Retinoic acid is an active metabolite of vitamin A (retinol). Cellular retinoic acid binding proteins (CRABP) are low molecular ... Cellular retinoic acid-binding protein 2 is a cytoplasmic binding protein that in humans is encoded by the CRABP2 gene. CRABP2 ... "Spatial and temporal patterns of expression of cellular retinol-binding protein and cellular retinoic acid-binding proteins in ... "Crystal structure of cellular retinoic acid binding protein I shows increased access to the binding cavity due to formation of ...
Inside the cells, vitamin B12 dissociates once again and binds to another protein, transcobalamin II (TCN2); the new complex ... Pancreatic exocrine insufficiency can interfere with normal dissociation of vitamin B12 from its binding proteins in the small ... is another glycoprotein secreted by the salivary glands which binds to vitamin B12. Vitamin B12 is acid-sensitive and in ... ISBN 978-81-203-5125-7. Shum HY, O'Neill BJ, Streeter AM (1971). "Effect of pH changes on the binding of vitamin B12 by ...
Sequential binding of actin monomers to plasma gelsolin and its inhibition by vitamin D-binding protein. Biochem Biophys Res ... The role of plasma gelsolin and the vitamin D-binding protein in clearing actin from the circulation. J Clin Invest. 1986; 78: ... Ligand-sensitive binding of the high-affinity IgG receptor (FcgR1) to actin-binding protein. Cell. 1991; 67:275-282. 114. ... Localization of the domain actin-binding protein that binds to glycoprotein Ib and actin in human platelets. J Biol Chem. 1988 ...
... s are proteins that bind lipids (oil-soluble substances such as fat and cholesterol) to form lipoproteins. They ... transport lipids (and fat soluble vitamins) in blood, cerebrospinal fluid and lymph. The lipid components of lipoproteins are ... The three-dimensional structure of the LDL receptor-binding domain of apoE indicates that the protein forms an unusually ... Apolipoprotein F (apoF) is one of the minor apolipoprotein in blood plasma and it is a lipid transfer inhibit protein to ...
pGSN along with Vitamin D-binding protein (DBP) bind and clear monomeric actin. DBP binds with greater affinity to G-actin, ... "Sequential binding of actin monomers to plasma gelsolin and its inhibition by vitamin D-binding protein". Biochemical and ... Lind, S E; Smith, D B; Janmey, P A; Stossel, T P (1986-09-01). "Role of plasma gelsolin and the vitamin D-binding protein in ... Cytoplasmic gelsolin Actin Vitamin D-binding protein Shi, Yigong (2004-08-01). "Caspase activation, inhibition, and ...
... or binding of vitamin A to receptor heterodimers. Antagonistic and synergistic interactions between these two vitamins have ... it was thought that the sole important retinoid delivery pathway to tissues involved retinol bound to retinol-binding protein ( ... Stimulation of bone resorption by vitamin A has been reported to be independent of its effects on vitamin D. Vitamin A exerts ... Vitamin A is fat-soluble and high levels have been reported affect metabolism of the other fat-soluble vitamins D, E, and K. ...
Such proteins bound calcium in the micromolar range and were greatly reduced in vitamin D-deficient animals. Expression could ... They were originally described as vitamin D-dependent calcium-binding proteins in the intestine and kidney in the chick and ... Wasserman RH, Taylor AN (May 1966). "Vitamin d3-induced calcium-binding protein in chick intestinal mucosa". Science. 152 (3723 ... Vitamin D-dependent calcium binding proteins were discovered in the cytosolic fractions of chicken intestine, and later in ...
Once interferon has bound to its receptors on the neighbouring cell, the signalling proteins STAT1 and STAT2 are activated and ... Piot concluded that Belgian nuns had inadvertently started the epidemic by giving unnecessary vitamin injections to pregnant ... EBOV's V24 protein blocks the production of these antiviral proteins by preventing the STAT1 signalling protein in the ... This processing appears to allow the virus to bind to cellular proteins enabling it to fuse with internal cellular membranes ...
... protein.[45] PPARα increases the activity of activator protein 1 (AP-1) and NF-κB, thereby leading to the recruitment of ... C. acnes' ability to bind and activate a class of immune system receptors known as toll-like receptors (TLRs), especially TLR2 ... Topical and oral preparations of nicotinamide (the amide form of vitamin B3) are alternative medical treatments.[147] ... Brescoll J, Daveluy S (February 2015). "A review of vitamin B12 in dermatology". American Journal of Clinical Dermatology ( ...
This results in a series of unstable intermediates, the last of which binds stronger to a G protein in the membrane, called ... attached to a covalently bound prosthetic group: an organic molecule called retinal (a derivative of vitamin A). The retinal ... The membranous photoreceptor protein opsin contains a pigment molecule called retinal. In rod cells, these together are called ... The photoreceptor proteins in the three types of cones differ in their sensitivity to photons of different wavelengths (see ...
"Mapping the Ligand-binding Sites and Disease-associated Mutations on the Most Abundant Protein in the Human, Type I Collagen". ... Scurvy, caused by a deficiency of vitamin C which is necessary for the synthesis of collagen. ... Bind bones and other tissues to each other. Alpha polypeptide chains. tendon, ligament, skin, cornea, cartilage, bone, blood ... Type I collagen is present in many forms of connective tissue, and makes up about 25% of the total protein content of the ...
AR NTD antagonists bind covalently to the NTD of the AR and prevent protein-protein interactions subsequent to activation that ... Vitamins and Hormones. Academic Press. 18 May 1976. pp. 682-. ISBN 978-0-08-086630-7.. ... cortisol binding to plasma proteins". J. Steroid Biochem. 33 (2): 251-5. doi:10.1016/0022-4731(89)90301-4. PMID 2788775.. ... of the AR rather than the ligand-binding domain (LBD).[100] Whereas conventional AR antagonists bind to the LBD of the AR and ...
Beta carotene, vitamin K, vitamin C, an calcium is rowth in kail. Kail is a soorce o twa carotenoids, lutein an zeaxanthin.[1] ... "Steam cooking significantly improves in vitro bile acid binding of collard greens, kale, mustard greens, broccoli, green bell ...
... or binding of vitamin A to receptor heterodimers. Antagonistic and synergistic interactions between these two vitamins have ... it was thought that the sole important retinoid delivery pathway to tissues involved retinol bound to retinol-binding protein ( ... Vitamin A is fat-soluble and high levels have been reported affect metabolism of the other fat-soluble vitamins D,[23] E, and K ... Vitamin K prevents hypoprothrombinemia in rats and can sometimes control the increase in plasma/cell ratios of vitamin A.[49] ...
"Benzopyrene and Vitamin A deficiency". Researcher links cigarettes, vitamin A and emphysema. Retrieved March 5, 2005.. ... It is this diol epoxide that covalently binds to DNA.. BaP induces cytochrome P4501A1 (CYP1A1) by binding to the AHR (aryl ... This process increases transcription of certain genes, notably CYP1A1, followed by increased CYP1A1 protein production.[28] ... A link between vitamin A deficiency and emphysema in smokers was described in 2005 to be due to BaP, which induces vitamin A ...
Water constitutes about 90% of this, with protein, trace minerals, fatty material, vitamins, and glucose contributing the ... At its isoelectric pH (6.5), it can bind two cations and assume a red or yellow color. These metal complexes are more heat ... Visual representation of protein denaturation. A globular protein becomes unfolded when exposed to heat. ... Some protein powders also use egg whites as a primary source of protein. ...
"Momordica charantia and its novel polypeptide regulate glucose homeostasis in mice via binding to insulin receptor". Journal of ... Protein. 0.84 g. Vitamins. Quantity %DV†. Vitamin A equiv.. beta-Carotene. lutein zeaxanthin ...
Kelly CJ, Stenton SR, Lashen H. Insulin-like growth factor binding protein-1 in PCOS: a systematic review and meta-analysis. ... Serum Vitamin D Levels and Polycystic Ovary syndrome: A Systematic Review and Meta-Analysis. Nutrients (Meta-analysis). 2015, 7 ... Krul-Poel YH, Snackey C, Louwers Y, Lips P, Lambalk CB, Laven JS, Simsek S. The role of vitamin D in metabolic disturbances in ... of the ratio of testosterone to sex hormone-binding globulin (SHBG) is high[15][61]and is meant to be a predictor of free ...
Heeb MJ, Rosing J, Bakker HM, et al. (1994). „Protein S binds to and inhibits factor Xa". Proc. Natl. Acad. Sci. U.S.A. 91 (7 ... A K-vitamin hiány vagy a warfarin (és hasonló gyógyszerek) inaktív X-es faktor termelődéshez vezetnek. A warfarinos kezelés ... Antitrombin · protein C · protein S · protein Z · Z fehérje függő proteáz inhibitor (ZPI) · Szöveti faktor útvonal gátló (TFPI ... Contributions of protein-protein and protein-membrane interactions toward complex formation". J. Biol. Chem. 265 (7), 3708-18. ...
Sterol Regulatory Element Binding Protein 1 and 2).[10] In the presence of cholesterol, SREBP is bound to two other proteins: ... is important for the absorption of the fat soluble vitamins, vitamins A, D, E, and K. It is the main precursor of vitamin D and ... The cleaved SREBP then migrates to the nucleus and acts as a transcription factor to bind to the SRE (sterol regulatory element ... The main regulatory mechanism is the sensing of intracellular cholesterol in the endoplasmic reticulum by the protein SREBP ( ...
In the case of a lipid panel, failure to fast for a full 12 hours (including vitamins) will guarantee an elevated triglyceride ... Observing the fast is an individual obligation and is binding on Bahá'ís between 15 years (considered the age of maturity) and ... the American Cancer Society recommended that people undergoing chemotherapy increase their intake of protein and calories. ...
Protein C (inhibits V, VIII)/Protein S (cofactor for protein C). *Protein Z (inhibits X) ... Vitamin K antagonists. (inhibit II, VII, IX, X). *Coumarins: Acenocoumarol. *Coumatetralyl. *Dicoumarol ...
cAMP binds to and releases an active form of protein kinase A (PKA). Next, PKA phosphorylates phosphorylase kinase, which, in ... Glycogen phosphorylase has a pyridoxal phosphate (PLP, derived from Vitamin B6) at each catalytic site. Pyridoxal phosphate ... Residues 397-437 form this structure, which allows the protein to covalently bind to the glycogen chain a full 30 Å from the ... Binding of AMP at this site, corresponding in a change from the T state of the enzyme to the R state, results in small changes ...
... is primarily (99.9%) bound to plasma proteins, mostly albumin. Three metabolites of Isotretinoin are detectable in ... Due to Isotretinoin's molecular relationship to Vitamin A, it should not be taken with Vitamin A supplements due to the danger ... It is a retinoid, meaning it is related to vitamin A, and is found in small quantities naturally in the body. Its isomer, ... Increasingly higher dosages will result in higher toxicity, resembling vitamin A toxicity. Adverse effects include:[23] ...
The DCXR gene encodes a membrane protein that is approximately 34 kDa in size and composed of 224 amino acids. The protein is ... Vitamin K epoxide reductase. *Vitamin-K-epoxide reductase (warfarin-insensitive). 1.1.5: quinone/similar acceptor. *Malate ... Over-expression and ectopic expression of the protein may be associated with prostate adenocarcinoma.[3] ...
Hunter T (January 1995). "Protein kinases and phosphatases: the yin and yang of protein phosphorylation and signaling". 》Cell》 ... Wagner AL (1975). 》Vitamins and Coenzymes》. Krieger Pub Co. ISBN 0-88275-258-8. .. ... Yoshikawa S, Caughey WS (May 1990). "Infrared evidence of cyanide binding to iron and copper sites in bovine heart cytochrome c ... Protein structure and function》. London: New Science. 27쪽. ISBN 978-1405119221. .. ...
Like most proteins, curculin is susceptible to heat. At a temperature of 50 °C (122 °F) the protein starts to degrade and lose ... Presence of Ca2+ and/or Mg2+, water and acids tune the binding of the active site of curculin to the receptor site and ... Sweetness was also observed with other acids such as ascorbic acid (vitamin C)[6] and acetic acid. ... Amino acid sequence of sweet protein curculin adapted from Swiss-Prot biological database of protein sequences.[3] ...
protein binding. • protease binding. • tumor necrosis factor receptor binding. • cytokine activity. • identical protein binding ... positive regulation of vitamin D biosynthetic process. • positive regulation of mononuclear cell migration. • MAPK cascade. • ... This dissociation enables the adaptor protein TRADD to bind to the death domain, serving as a platform for subsequent protein ... An inhibitory protein, IκBα, that normally binds to NF-κB and inhibits its translocation, is phosphorylated by IKK and ...
proteins. In enzymology, a homoisocitrate dehydrogenase (EC 1.1.1.87) is an enzyme that catalyzes the chemical reaction ... Vitamin K epoxide reductase. *Vitamin-K-epoxide reductase (warfarin-insensitive). 1.1.5: quinone/similar acceptor. *Malate ...
Rouaux C, Loeffler JP, Boutillier AL (September 2004). "Targeting CREB-binding protein (CBP) loss of function as a therapeutic ... Folate and other B vitamins. B vitamins are involved in the metabolic pathway that leads to SAM production. SAM is the donor of ... The UBQLN2 gene encodes the protein ubiquilin 2 which is responsible for controlling the degradation of ubiquitinated proteins ... As that gene's name suggests, BACE1 is an enzymatic protein that cleaves the Amyloid Precursor Protein into the insoluble ...
protein binding. Cellular component. • extracellular region. • specific granule. • intracellular. • extracellular exosome. • ... Higher plasma levels of human cathelicidin antimicrobial protein (hCAP18), which are up-regulated by vitamin D, appear to ... a novel antimicrobial lipopolysaccharide-binding protein". Infection and Immunity. 63 (4): 1291-7. PMC 173149 . PMID 7890387.. ... which is the hormonally active form of vitamin D.[7] The protein encoded by the human cathelicidin gene, CAMP, is cleaved into ...
Commonly consumed food components containing calories are carbohydrates, proteins and fat. In preliminary research, some non- ... Prolonged severe CR lowers total serum and free testosterone while increasing sex hormone binding globulin concentrations in ... Vitamins. *Vitamin A. *Vitamin B1. *Vitamin B2. *Vitamin B3 ... brain and heart proteins, and mice placed on CR at 19 months of ... "Dietary Protein and Weight Reduction: A Statement for Healthcare Professionals From the Nutrition Committee of the Council on ...
A tomato is 95% water, contains 4% carbohydrates and less than 1% each of fat and protein (table). In a 100 gram amount, raw ... There are varieties high in beta carotenes and vitamin A, hollow tomatoes and tomatoes that keep for months in storage.[ ... "Granule-bound starch synthase (GBSSI) gene phylogeny of wild tomatoes (Solanum L. section Lycopersicon (Mill.) Wettst. ... The hormone was first identified in tomatoes, but similar proteins have been identified in other species since.[54] ...
... by cleaving sugars that bind the mature viral particles.[66] Thus, these proteins are targets for antiviral drugs.[67] ... An alternative hypothesis to explain seasonality in influenza infections is an effect of vitamin D levels on immunity to the ... matrix 1 protein), M2, NS1 (non-structural protein 1), NS2 (other name is NEP, nuclear export protein), PA, PB1 (polymerase ... or transported back into the nucleus to bind vRNA and form new viral genome particles (step 5a). Other viral proteins have ...
Hypocalcemia (low calcium) is also seen due to poor absorption of vitamin D and calcium, and secondary to low protein binding ... chronic diarrhea and loss of proteins such as serum albumin and globulin. It is considered to be a chronic form of protein- ... A diet very low in fat and high in high quality protein is essential. Treatment of humans can also involve the use of MCT ( ... Willard, Michael (2005). "Protein-Losing Enteropathy in Dogs and Cats". Proceedings of the 30th World Congress of the World ...
We combine protein signatures from a number of member databases into a single searchable resource, capitalising on their ... InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites ... Vitamin D-binding protein (DBP) is an abundant serum glycoprotein secreted by the liver; the protein transports vitamin D ... GO:0051180 vitamin transport Molecular Function. GO:0005499 vitamin D binding GO:0090482 vitamin transmembrane transporter ...
... Zhongjian Xie,1 Arthur C. Santora,2 Sue A. Shapses,3 and Xiangbing Wang4 ... Zhongjian Xie, Arthur C. Santora, Sue A. Shapses, and Xiangbing Wang, "Vitamin D Binding Protein and Vitamin D Levels," ...
Goat polyclonal Vitamin D Binding protein antibody validated for WB, ELISA and tested in Human. Immunogen corresponding to ... Anti-Vitamin D Binding protein antibody. See all Vitamin D Binding protein primary antibodies. ... Anti-Vitamin D Binding protein antibody (ab77357) at 0.03 µg/ml + Tissue lysates prepared from Lung tissue at 35 µg. Predicted ... human) from the internal region of the Vitamin D Binding Protein sequence according to NP_000574.2. ...
Vitamin D plasma binding protein. Turnover and fate in the rabbit.. J G Haddad, D R Fraser, and D E Lawson ... The radioiodine-labeled protein retained its ability to bind vitamin D sterols and its physicochemical properties. When 125I- ... The metabolic disposition of the plasma binding protein (DBP) for vitamin D and its metabolites was studied in adult rabbits. ... and dynamic transport mechanism for vitamin D sterols exists in rabbit plasma. ...
9781439880166 Our cheapest price for Vitamin-Binding Proteins: Functional Consequences is $27.07. Free shipping on all orders ... Minor changes in the chemical structure of vitamins can cause major differences in their binding to proteins and therefore in ... This book summarizes the current knowledge base with regard to vitamin-binding proteins. The text stresses the ways in which ... vitamin bonds to proteins offer therapeutic potential for various diseases. Using a systems-based approach, the authors cover ...
This protein contains 47-50 amino acid residues (molecular weight 5,200-5,900) depending on the species. Osteocalcin is ... Osteocalcin is an abundant Ca2+-binding protein indigenous to the organic matrix of bone, dentin, and possibly other ... Osteocalcin: the vitamin K-dependent Ca2+-binding protein of bone matrix Haemostasis. 1986;16(3-4):258-72. doi: 10.1159/ ... and the protein is not homologous to the Gla-containing regions of known vitamin-K-dependent blood coagulation proteins. The ...
Crystal structures of the vitamin D-binding protein and its complex with actin: structural basis of the actin-scavenger system. ... Structures of protein chains with identical sequences (sequence identity > 95%) are aligned, superimposed and clustered. ... This allows for the easy identification of regions and types of structural flexibility present in a protein of interest. ... The PDBFlex database explores the intrinsic flexibility of protein structures by analyzing structural variations of the same ...
Vitamin D-binding protein (DBP), also/originally known as gc-globulin (group-specific component), is a protein that in humans ... Constans J, Oksman F, Viau M (August 1981). "Binding of the apo and holo forms of the serum vitamin D-binding protein to human ... It is able to bind the various forms of vitamin D including ergocalciferol (vitamin D2) and cholecalciferol (vitamin D3), the ... "Vitamin D-binding protein and vitamin D status of black Americans and white Americans". The New England Journal of Medicine. ...
We investigated the possibility that the multifunctional serum protein Gc-globulin (vitamin D-binding protein) may also enhance ... Gc-globulin (vitamin D-binding protein) enhances the neutrophil chemotactic activity of C5a and C5a des Arg.. Kew RR1, Webster ... This enhancing activity was not due to a nonspecific effect of anionic proteins since other purified serum proteins, of similar ... Several serum proteins have been shown to be important in modulating leukocyte chemotaxis and inflammation. ...
... Elena Doldo, Gaetana Costanza, ... The New Role of Cellular Retinol Binding Proteins," BioMed Research International, vol. 2015, Article ID 624627, 14 pages, 2015 ... Elena Doldo, Gaetana Costanza, Sara Agostinelli, et al., "Vitamin A, Cancer Treatment and Prevention: ...
The vitamin D axis in the lung: a key role for vitamin D-binding protein. Thorax 2010;65:456-62. ... Vitamin D-binding protein directs monocyte responses to 25-hydroxy- and 1,25-dihydroxy vitamin D. J Clin Endocrinol Metab 2010; ... Elastase controls the binding of the vitamin D-binding protein (Gc-globulin) to neutrophils: a potential role in the regulation ... Proposed consequences of variation in vitamin D-binding protein (DBP) in the lung. The GC2 haplotype codes for the GC2 protein ...
Relationships among vitamin D, 25-hydroxyvitamin D, and vitamin D-binding protein concentrations in the plasma and milk of ... and vitamin D-binding protein (DBP) in a group of lactating women. All vitamin D compounds were quantitated using competitive ... Vitamin D3 was the most abundant vitamin D compound in human milk, followed by vitamin D2, 25OHD3, and, finally, 25OHD2. The ... The milk to blood concentration ratio was greatest for vitamin D2, followed by vitamin D3, 25OHD2, and 25OHD3. (Thus, the ...
The multifunctional vitamin D binding protein (DBP) is an actin-sequestering protein present in blood. The crystal structure of ... The multifunctional vitamin D binding protein (DBP) is an actin-sequestering protein present in blood. The crystal structure of ... A structural basis for the unique binding features of the human vitamin D-binding protein. Verboven, C., Rabijns, A.,& ... Vitamin D-binding protein. A. 458. Homo sapiens. Mutation(s): 0 Gene Names: GC. ...
Vitamin D binding protein domain III protein domain is predominantly found in Vitamin D binding proteins (DBP). Vitamin D- ... "Identification of two distinct cell binding sequences in the vitamin D binding protein". Biochim Biophys Acta. 1803 (5): 623-9 ... Otterbein LR, Cosio C, Graceffa P, Dominguez R (June 2002). "Crystal structures of the vitamin D-binding protein and its ... It is required for formation of an actin clamp, allowing the protein to bind to actin. This protein is a member of the ...
... had low levels of total 25-hydroxyvitamin D and vitamin D-binding protein, resulting in similar concentrations of estimated ... Vitamin D-binding Protein and Vitamin D Status of Black Americans and White Americans N Engl J Med. 2013 Nov 21;369(21):1991- ... Vitamin D-binding protein has not been considered in the assessment of vitamin D deficiency. ... Results: Mean (±SE) levels of both total 25-hydroxyvitamin D and vitamin D-binding protein were lower in blacks than in whites ...
Vitamin D Binding Protein and 25-Hydroxyvitamin D Levels: Emerging Clinical Applications ... Vitamin D Binding Protein and 25-Hydroxyvitamin D Levels: Emerging Clinical Applications ...
Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport ... The complex is composed of two ATP-binding proteins (BtuD), two transmembrane proteins (BtuC) and a solute-binding protein ( ... Vitamin B12 import ATP-binding protein BtuDUniRule annotation. Manual assertion according to rulesi ... sp,A8A0Q1,BTUD_ECOHS Vitamin B12 import ATP-binding protein BtuD OS=Escherichia coli O9:H4 (strain HS) OX=331112 GN=btuD PE=3 ...
... vitamin D binding protein (DBP), parathyroid hormone (PTH) and bone traits. Methods 595 37-47-year-old healthy Finnish men and ... Background characteristic and intakes of vitamin D and calcium were collected. The concentrations of 25(OH)D, PTH, DBP, albumin ... and PTH suggest that obese subjects may differ from normal-weight subjects in vitamin D metabolism. BMI associated positively ... Background Studies have shown altered vitamin D metabolism in obesity. We assessed differences between obese and normal-weight ...
Vitamin D Deficiency. VDD. Vitamin D Supplementation. Vitamin D Binding Protein. DBP. Nutritional rickets. rickets. ... Osteopathy and resistance to vitamin D toxicity in mice null for vitamin D binding protein. J Clin Invest. 1999 Jan;103(2):239- ... The purpose of this study is to determine if the vitamin D binding protein genotype influences circulating vitamin D levels and ... Effects of Vitamin D Dose and Genotype of the Binding Protein in Infants and Children (VitaD). This study has been completed. ...
Vitamin D Binding protein blocking peptide, GTX88762-PEP, Applications: Apuri, Blocking, ELISA; Affinity purification, Blocking ... vitamin D-binding protein/group, vitamin D-binding protein, DBP, Vitamin Dbinding protein / GC, GC, vitamin Dbinding protein/ ... group-specific component (vitamin D binding protein). Synonyms. vitamin D binding protein, VDBP, vitamin Dbinding protein, DBP/ ... Vitamin D Binding protein blocking peptide See all Vitamin D Binding protein products ...
Meaning of vitamin d-binding protein. What does vitamin d-binding protein mean? Information and translations of vitamin d- ... binding protein in the most comprehensive dictionary definitions resource on the web. ... Definition of vitamin d-binding protein in the Definitions.net dictionary. ... Vitamin D-binding protein. Vitamin D-binding protein also known as gc-globulin is a protein that in humans is encoded by the GC ...
... vitamin D binding protein)) for ICC/IF, IHC-P, WB. Anti-Vitamin D Binding Protein pAb (GTX109955) is tested in Human, Mouse ... Vitamin D Binding Protein antibody (group-specific component ( ... Vitamin D Binding Protein protein stained by Vitamin D Binding ... Green: Vitamin D Binding Protein protein stained by Vitamin D Binding Protein antibody (GTX109955) diluted at 1:500.. Blue: ... Vitamin D Binding Protein antibody detects Vitamin D Binding Protein protein at cytoplasm by immunofluorescent analysis. ...
Vitamin D binding protein and risk of renal cell carcinoma in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening ... The highest vs lowest quartile of vitamin D binding protein was associated with 4.1-fold increased odds of renal cell carcinoma ... High serum levels of vitamin D binding protein (DBP) are associated with an increased risk of renal cell carcinoma (RCC), ... Close more info about High Vitamin D Binding Protein Levels Up RCC Risk ...
Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport ... The complex is composed of two ATP-binding proteins (BtuD), two transmembrane proteins (BtuC) and a solute-binding protein ( ... Vitamin B12 import ATP-binding protein BtuDUniRule annotation. Manual assertion according to rulesi ... sp,Q5PH81,BTUD_SALPA Vitamin B12 import ATP-binding protein BtuD OS=Salmonella paratyphi A (strain ATCC 9150 / SARB42) OX= ...
vitamin D binding protein. Synonyms: DBP, vitamin D binding protein. Gene nomenclature, locus information, and GO, OMIM, and ...
... for Vitamin D depletion, IVD manufacturing and life science applications - Inquire for details! ... Buy high purity Vitamin D-Binding Protein (DBP) ... Binding of the various forms of Vitamin D (Vitamin D2, Vitamin ... Lee Biosolutions is the leading supplier of Vitamin D-Binding Protein from human plasma for removal of Vitamin D from base ... Home / Antigens / Enzymes / Antigens / Standards / Controls / Proteins / Vitamin D-binding Protein (dbp) ...
Initial Characterization of the Vitamin D Binding Protein (Gc-Globulin) Binding Site on the Neutrophil Plasma Membrane: ... Initial Characterization of the Vitamin D Binding Protein (Gc-Globulin) Binding Site on the Neutrophil Plasma Membrane: ... Initial Characterization of the Vitamin D Binding Protein (Gc-Globulin) Binding Site on the Neutrophil Plasma Membrane: ... Initial Characterization of the Vitamin D Binding Protein (Gc-Globulin) Binding Site on the Neutrophil Plasma Membrane: ...
The vitamin D binding protein (DBP),3 also known as Gc-globulin, is a multifunctional plasma protein that can bind several ... Binding of Gc globulin (vitamin D binding protein) to C5a or C5a des Arg is not necessary for co-chemotactic activity. J. ... Gc (vitamin D binding protein) binds to cytoplasm of all human lymphocytes and is expressed on B-cell membranes. Clin. Immunol ... The vitamin D binding protein (DBP) is a multifunctional plasma protein that can modulate certain immune and inflammatory ...
Cellular Binding Proteins for Vitamin A in Human Carcinomas and in Normal Tissues. Prabhudas R. Palan and Seymour L. Romney ... Cellular Binding Proteins for Vitamin A in Human Carcinomas and in Normal Tissues ... Cellular Binding Proteins for Vitamin A in Human Carcinomas and in Normal Tissues ... Cellular Binding Proteins for Vitamin A in Human Carcinomas and in Normal Tissues ...
  • Vitamin D-binding protein (VDBP) levels, however, fluctuate less with season and sunlight. (ovid.com)
  • Vitamin D deficiency was uncommon in our patients with CD in remission, and serum 25(OH)D3 did not predict disease flare, whereas higher VDBP concentrations were significantly associated with disease flare. (ovid.com)
  • One of the substances responsible for the transport of vitamin D is Gc-globulin, also called vitamin D binding protein, VDBP. (termedia.pl)
  • 4 This is indicative of a role of VDBP gene polymorphism in determining serum concentrations of vitamin D3 in certain populations. (org.pk)
  • The current study was planned to find out whether genotypes/diplotypes of VDBP have any association with T2DM, and to investigate any relationship of vitamin D deficiency with T2DM. (org.pk)
  • Vitamin D-binding protein (VDBP) mediates various biological processes in humans. (bvsalud.org)
  • Concentrations of VDBP were measured using a vitamin D BP Quantikine ELISA kit. (bvsalud.org)
  • Vitamin D (VitD) and Vitamin D binding protein (VDBP) has potency to act as an immune modulator. (oatext.com)
  • The present study was undertaken to examine the effects of a 34-week vitD supplementation of ImmunoDÒ, a stabilized Vitamin D3 complex, in a patient with ALS on oxidative stress parameters, nitrosative stress parameter, VitD status and VDBP. (oatext.com)
  • Vitamin D binding protein (VDBP) serves several important functions in the body and is probably best known for its role in the transport of vitamin D. (nist.gov)
  • BACKGROUND: Previous studies of vitamin D binding protein (VDBP, also known as group-specific component, Gc, encoded by the GC gene) have implicated two gene variants, GC*2 and GC*1F, as possible contributors with chronic obstructive pulmonary disease (COPD) protection and susceptibility, respectively. (lsh.is)
  • however, limited data are available on the association of vitamin D-binding protein (VDBP)-a major transport protein for vitamin D-and the development of HF. (umn.edu)
  • The association of gene encoding vitamin D binding protein (VDBP, GC) with COPD has been controversial. (yonsei.ac.kr)
  • Haptoglobin-α1 (Hp-α1) and -α2 (Hp-α2) and vitamin D-binding protein (VDBP) were found to be significantly upregulated in responder sera ( P ≤0.02) at study entry. (biomedcentral.com)
  • article{3b718d7a-9563-4a26-8ecd-e07c759f8e64, abstract = {An association between low serum vitamin D levels and poorer melanoma survival has been reported. (lu.se)
  • abstract = "Background: Vitamin D status may influence a spectrum of health outcomes, including osteoporosis, arthritis, cardiovascular disease, and cancer. (elsevier.com)
  • abstract = " Milk is an important source of highly bioavailable vitamin B 12 (cobalamin) in human nutrition. (au.dk)
  • abstract = "Vitamin E (RRR-alpha-tocapherol) is a lipid-soluble antioxidant that is present in the membranes of intracellular organelles. (elsevier.com)
  • abstract = "Qualitative and quantitative studies of Gc (Vitamin D‐binding protein) were carried out with whole and parotid saliva from 13 patients with periodontal disease, and 19 control subjects. (elsevier.com)
  • the protein transports vitamin D sterols, binds to actin, and is found on the surface of B-lymphocytes and subpopulations of T-lymphocytes [ PMID: 2419332 ]. (ebi.ac.uk)
  • In plasma, it carries the vitamin D sterols and prevents polymerization of actin by binding its monomers. (abcam.com)
  • 6 It is expressed in many tissues, 7 and by neutrophils, 8 contributes to macrophage activation, 9 augments monocyte and neutrophil chemotaxis to C5-derived peptides and acts as an actin scavenger protein, as discussed in our recent review. (bmj.com)
  • 4 In simplified terms, domain I binds vitamin D while domain III binds actin, functions which are independent of each other. (bmj.com)
  • The multifunctional vitamin D binding protein (DBP) is an actin-sequestering protein present in blood. (rcsb.org)
  • Most remarkably, DBP demonstrates an unusually large actin-binding interface, far exceeding the binding-interface areas reported for other actin-binding proteins such as profilin, DNase I and gelsolin. (rcsb.org)
  • It establishes DBP as the hitherto best actin-sequestering protein and highlights its key role in suppressing and preventing extracellular actin polymerization. (rcsb.org)
  • Domain III (amino acid 379-458) is G-actin binding region located in the C-terminal. (wikipedia.org)
  • It is required for formation of an actin 'clamp', allowing the protein to bind to actin. (wikipedia.org)
  • DBP functions to transport vitamin D sterols, acts as a scavenger protein to clear extracellular G-actin released from necrotic cells, and a deglycoslated form of DBP has been shown to be a potent macrophage activating factor ( 5 ). (jimmunol.org)
  • Moreover, the binding of DBP to its putative cell surface binding site may be important for several other functions of the protein, including delivery of vitamin D sterols, clearance of DBP-G actin complexes, and activation of macrophages. (jimmunol.org)
  • BACKGROUND: Vitamin D binding protein (DBP) acts as a vitamin D carrier and an actin scavenger. (ugent.be)
  • Total serum DBP concentration and the actin-bound DBP/DBP ratio correlated significantly with total cholesterol, LDL-cholesterol, triglycerides and albumin. (ugent.be)
  • The actin-bound DBP complex was identified with Western blot.CONCLUSIONS: The lipid-bound DBP fraction may be of greater importance than initially thought. (ugent.be)
  • It is able to bind to and block the polymerization of monomeric actin. (elsevier.com)
  • A recent study found that vitamin D deficiency predicted a greater decline in pulmonary function tests among patients with COPD. (vitamindcouncil.org)
  • When maintained on vitamin D-deficient diets for a brief period, the DBP-/-, but not DBP+/+, mice developed secondary hyperparathyroidism and the accompanying bone changes associated with vitamin D deficiency. (jci.org)
  • Bone mineralization defect after mild dietary vitamin D deficiency in DBP -/- mice. (jci.org)
  • Vitamin D deficiency was defined as a plasma 25-hydroxyvitamin D 3 level lower than 20 ng/mL. (dovepress.com)
  • The GC2 variant was a significant risk factor for vitamin D deficiency (odds ratio =2.41). (dovepress.com)
  • Among COPD clinical parameters, vitamin D deficiency was associated with a lower ratio of forced expiratory volume in 1 second to forced vital capacity (FEV 1 /FVC) regardless of GC polymorphisms. (dovepress.com)
  • The GC2 variant is a risk factor for vitamin D deficiency, and genotype 1F-1S is a protective factor against vitamin D deficiency. (dovepress.com)
  • GC polymorphisms and vitamin D deficiency correlate with clinical outcomes for Korean patients with COPD. (dovepress.com)
  • Circulating DBP related inversely to forced expiratory volume in 1 s (FEV 1 ) (p=0.02), in direct contrast to vitamin D, where deficiency related to low FEV 1 (p=0.04). (bmj.com)
  • Vitamin D-binding protein has not been considered in the assessment of vitamin D deficiency. (nih.gov)
  • Advantages to the prevention of vitamin D deficiency (VDD) in young children are obvious: acutely, hypocalcemic seizures may occur in VDD, and rickets can result in long-term skeletal deformities. (clinicaltrials.gov)
  • Vitamin D (25(OH)D) deficiency occurs in active Crohn's disease (CD) and may be secondary to reduced sunlight exposure and oral intake. (ovid.com)
  • Background: Vitamin D deficiency is common in immigrants. (alliedacademies.org)
  • Bioavailable vitamin D may be used for diagnosing vitamin D deficiency in order to exclude overestimated vitamin D deficiency in dark-skinned people. (alliedacademies.org)
  • The prevalence of vitamin D deficiency and insufficiency is extremely high in pregnant women worldwide. (cdc.gov)
  • The risk of adverse neonatal outcomes due to maternal vitamin D deficiency has not been well investigated. (cdc.gov)
  • Recent reports have shown that vitamin D deficiency is widespread in both developed and developing countries. (org.pk)
  • Nearly 1 billion people around the world appear to be suffering from vitamin D deficiency or insufficiency. (org.pk)
  • Vitamin D deficiency is associated with muscle weakness and osteoporosis and can. (nist.gov)
  • In humans, vitamin C deficiency leads to impaired collagen synthesis, contributing to the more severe symptoms of scurvy . (wikipedia.org)
  • Scurvy is a disease resulting from a deficiency of vitamin C, since without this vitamin, collagen made by the body is too unstable to perform its function. (wikipedia.org)
  • however, the most prevalent one is the vitamin D deficiency. (intechopen.com)
  • For this reason, studies and research were directed toward fortifying consumed food with vitamins that are most likely to be deficient and their deficiency could pose tremendous health problems. (intechopen.com)
  • One of the most popular nutritional deficiencies in Lebanon and the Middle East is vitamin D deficiency. (intechopen.com)
  • Due to the high frequency of vitamin D deficiency in Middle East and Lebanon, it is essential to find a product that is widely consumed among the population and provides a good source of vitamin D regarding its stability. (intechopen.com)
  • Although vitamin A deficiency (VAD) in resource-limited settings is still an actual issue and represents the leading cause of preventable childhood blindness, its occurrence in high-income countries is rare, although possibly underdiagnosed because of its nonspecific early manifestations. (aappublications.org)
  • Vitamin A deficiency (VAD) is considered one of the most prevalent micronutrient deficiencies worldwide, mainly affecting children in developing countries [ 1 ]. (mdpi.com)
  • The metabolic disposition of the plasma binding protein (DBP) for vitamin D and its metabolites was studied in adult rabbits. (jci.org)
  • On vitamin D-replete diets, DBP-/- mice had low levels of total serum vitamin D metabolites but were otherwise normal. (jci.org)
  • Thus, the role of DBP is to maintain stable serum stores of vitamin D metabolites and modulate the rates of its bioavailability, activation, and end-organ responsiveness. (jci.org)
  • It transports vitamin D metabolites between skin, liver and kidney, and then on to the various target tissues. (wikipedia.org)
  • Click on genes, proteins and metabolites below to link to respective articles. (wikipedia.org)
  • It is apparently synthesized in the liver and carries vitamin D and its metabolites through the circulation and mediates the response of tissue. (definitions.net)
  • It binds to vitamin D and its plasma metabolites and transports them to target tissues. (genetex.com)
  • Vitamin D-binding protein (DBP) is the main carrier of vitamin D and its metabolites in the circulation. (alliedacademies.org)
  • Vitamin D binding protein (DBP) concentration is known to influence the availability and bioactivity of vitamin D metabolites but its diurnal rhythm (DR), its inter-relationships with the DRs of vitamin D metabolites and its influence on free vitamin D metabolite concentrations are not well described. (uea.ac.uk)
  • Gambians had significantly higher plasma concentrations of vitamin D metabolites and lower albumin concentration compared to the British and Chinese. (uea.ac.uk)
  • Vitamin D refers to two fat soluble substances, vitamin D 3 (cholecalciferol) and vitamin D 2 (ergocalciferol), and their metabolites, which are considered to be important nutrients for human health. (mdpi.com)
  • Vitamin D binding protein (DBP)/group-specific component (Gc), correlates positively with serum vitamin D metabolites, and phenotype influences serum 25-hydroxyvitamin D (S-25(OH)D) concentration. (ucc.ie)
  • BACKGROUND: A low vitamin D status has been associated with multiple sclerosis (MS). Most circulating vitamin D metabolites are bound to vitamin D binding protein (DBP). (maastrichtuniversity.nl)
  • Therefore, the measurement of additional biomarkers to include vitamin D metabolites, markers of bone turnover and osteokines to include receptor activator of nuclear factor kappa-B ligand, osteoprotegerin, and sclerostin, is critical when interpreting the effect of PTH on bone tissue. (springer.com)
  • They have been proposed to account for some of the differences in vitamin D status in different ethnic groups, and have been found to correlate with the response to vitamin D supplementation. (wikipedia.org)
  • Previous research has emphasized the importance of identifying optimal supplementation doses and appropriate target thresholds for circulating 25-hydroxyvitamin D (25-OHD), the best described marker of vitamin D status. (clinicaltrials.gov)
  • Vitamin D3 Supplementation During Pregnancy and Lactation Improves Vitamin D Status of the Mother-Infant Dyad. (semanticscholar.org)
  • Maternal Versus Infant Vitamin D Supplementation During Lactation: A Randomized Controlled Trial. (semanticscholar.org)
  • Maternal vitamin D₃ supplementation at 50 μg/d protects against low serum 25-hydroxyvitamin D in infants at 8 wk of age: a randomized controlled trial of 3 doses of vitamin D beginning in gestation and continued in lactation. (semanticscholar.org)
  • The influence of variants of rs17467825, rs4588, rs2282679, and rs2298850 on maternal 25(OH)D might be modified by vitamin D supplementation and sunshine exposure. (cdc.gov)
  • IMSEAR at SEARO: Effect of vitamin B12 supplementation on serum vitamin B12 and vitamin B12 binding protein. (who.int)
  • Areekul S, Sabcharoen A, Cheeramakara C, Srisukawat K. Effect of vitamin B12 supplementation on serum vitamin B12 and vitamin B12 binding protein. (who.int)
  • The effects observed for vitamin D 3 supplementation remained unchanged when grouped by various characteristics. (bmj.com)
  • However, for vitamin D 2 supplementation, increased risks of mortality were observed in studies with lower intervention doses and shorter average intervention periods. (bmj.com)
  • however, before any widespread supplementation, further investigations will be required to establish the optimal dose and duration and whether vitamin D 3 and D 2 have different effects on mortality risk. (bmj.com)
  • With the preventive potential of this biologically active agent, we suggest that countries where cancer is on the rise-yet where sunlight and, hence, vitamin D may be easily acquired-adopt awareness, education and implementation strategies to increase supplementation with vitamin D in all age groups as a preventive measure to reduce cancer risk and prevalence. (mdpi.com)
  • Vitamin A supplementation (VAS) programs targeted at children aged 6-59 months are implemented in many countries. (mdpi.com)
  • Furthermore, we explored correlations of DBP with 25- hydroxyvitamin D (25(OH)D) and 1,25-dihydroxyvitamin D levels (1,25(OH)2D), and the effect of high-dose vitamin D3 supplementation on DBP levels in RRMS patients (n = 15). (maastrichtuniversity.nl)
  • Upon supplementation of high doses vitamin D3, DBP concentration remained unaltered. (maastrichtuniversity.nl)
  • After high-dose vitamin D supplementation, DBP concentrations may be relevant for vitamin D metabolism. (maastrichtuniversity.nl)
  • A number of serum transport proteins are known to be evolutionarily related, including albumin, alpha-fetoprotein, vitamin D-binding protein and afamin [ PMID: 2481749 , PMID: 2423133 , PMID: 7517938 ]. (ebi.ac.uk)
  • Amphibian albumins as members of the albumin, alpha-fetoprotein, vitamin D-binding protein multigene family. (ebi.ac.uk)
  • Complete amino acid sequence of human vitamin D-binding protein (group-specific component): evidence of a three-fold internal homology as in serum albumin and alpha-fetoprotein. (ebi.ac.uk)
  • Afamin is a new member of the albumin, alpha-fetoprotein, and vitamin D-binding protein gene family. (ebi.ac.uk)
  • Vitamin D-binding protein belongs to the albumin gene family, together with human serum albumin and alpha-fetoprotein. (wikipedia.org)
  • This protein is a member of the albumin gene family and has the characteristic multiple disulfide-bonded, triple domain structure. (wikipedia.org)
  • The protein encoded by this gene belongs to the albumin gene family. (genetex.com)
  • DBP is a member of the albumin and α-fetoprotein gene family and shares considerable amino acid homology with these proteins ( 3 , 4 ). (jimmunol.org)
  • About 88% of the 25(OH)D and 85% of the 1,25(OH)D are bound to vitamin D binding protein, and a further 10-13% to albumin. (termedia.pl)
  • Together with the vitamin D bound to albumin, this makes up the bioavailable fraction. (termedia.pl)
  • Most of the circulating S-25(OH) D and calcitriol (S-1, 25(OH)2 D) is strongly bound to DBP and 10-15% is loosely bound to albumin. (alliedacademies.org)
  • A small amount of loosely albumin-bound vitamin D and the fraction of the free form determine the bioavailable state of the vitamin, which is also biologically active according to "The free hormone hypothesis"[ 4 ]. (alliedacademies.org)
  • If the Vitamin D (25 OH) concentration and serum albumin are provided by the client, we could calculate bioavailable vitamin D using Vitamin D binding protein concentration. (panlaboratories.com)
  • The DRs of plasma total 25(OH)D, total 1,25(OH)2D, DBP, albumin and calculated free 25(OH)D and free 1,25(OH)2D were measured in men and women aged 60-75 years and resident in the UK (n 30), Gambia (n 31) and China (n 30) with differences in lifestyle, dietary intake and vitamin D status. (uea.ac.uk)
  • Vitamin A, Cancer Treatment and Prevention: The New Role of Cellular Retinol Binding Proteins," BioMed Research International , vol. 2015, Article ID 624627, 14 pages, 2015. (hindawi.com)
  • There were no significant differences between the log-mean concentrations of cellular retinol-binding proteins in the cytosols from tissue aliquots of carcinoma of the cervix and those in the cytosols from tissue aliquots of normal cervix. (aacrjournals.org)
  • This peptide was used for the production of goat polyclonal anti-Vitamin D binding protein antibody (GTX88762). (genetex.com)
  • Vitamin D Binding Protein antibody detects Vitamin D Binding Protein protein at cytoplasm by immunofluorescent analysis. (genetex.com)
  • Green: Vitamin D Binding Protein protein stained by Vitamin D Binding Protein antibody (GTX109955) diluted at 1:500. (genetex.com)
  • Vitamin D Binding Protein antibody detects GC protein by western blot analysis. (genetex.com)
  • Immunohistochemical analysis of paraffin-embedded Cal27 xenograft, using Vitamin D Binding Protein(GTX109955) antibody at 1:500 dilution. (genetex.com)
  • Vitamin D BP is quantitated using a sandwich immunoassay using monoclonal antibodies , one as capture and other as tag antibody , conjugated with horse raddish peroxidase (HRP). (panlaboratories.com)
  • The plasma vitamin D3 level was lower in patients with the GC2 variant (estimated =-3.73 ng/mL) and higher in those with genotype 1F-1S (estimated =4.08 ng/mL). (dovepress.com)
  • The emphysema index was higher for patients with the GC1S variant (estimated =6.56%) and genotype 1F-1S (estimated =9.86%), regardless of the vitamin D level. (dovepress.com)
  • The purpose of this study is to determine if the vitamin D binding protein genotype influences circulating vitamin D levels and if it may have functional consequences on vitamin D activity. (clinicaltrials.gov)
  • We provide evidence that a significant component of this variability is genetic in nature and in particular, relates to vitamin D binding protein (DBP) genotype. (clinicaltrials.gov)
  • Multiple conditional logistic regression revealed an association of group-specific 1-2 genotype with patients when adjusted for age, body mass index, and serum levels of 25 hydroxy vitamin D with matched adjusted odds ratio (95% confidence interval) being 3.1(1.22-7.88). (org.pk)
  • Group-specific 1-2 genotype of vitamin D binding protein gene was associated with the risk of type 2 diabetes. (org.pk)
  • The results suggest a role for vitamin D--dependent calcium binding protein in intracellular calcium metabolism rather than a direct involvement in membrane-mediated calcium reabsorption in the avian kidney. (sciencemag.org)
  • A line of mice deficient in vitamin D binding protein (DBP) was generated by targeted mutagenesis to establish a model for analysis of DBP's biological functions in vitamin D metabolism and action. (jci.org)
  • The various forms of vitamin D include not only its hydroxylated form (25(OH)D), but also the free and bioavailable fraction of this vitamin, as well as factors engaged in its metabolism such as the so-called membrane transport protein (Gc-globulin). (termedia.pl)
  • Moreover, the complex metabolism of vitamin D, including its transformations and transport, determines its total and bioavailable pool, and it also depends on the calcium and parathyroid hormone concentrations in the blood [3, 5, 6]. (termedia.pl)
  • Clinical review: The role of the parent compound vitamin D with respect to metabolism and function: Why clinical dose intervals can affect clinical outcomes. (semanticscholar.org)
  • James, W P T. / Vitamin-E requirements, transport, and metabolism : role of alpha-tocopherol-binding proteins . (elsevier.com)
  • Fingerprint Dive into the research topics of 'Stabilization of the structure of horse plasma vitamin D binding protein by disulfide bonds. (elsevier.com)
  • Fingerprint Dive into the research topics of 'Sequence of rat intestinal vitamin D-dependent calcium-binding protein derived from a cDNA clone. (nyu.edu)
  • It is able to bind the various forms of vitamin D including ergocalciferol (vitamin D2) and cholecalciferol (vitamin D3), the 25-hydroxylated forms (calcifediol), and the active hormonal product, 1,25-dihydroxyvitamin D (calcitriol). (wikipedia.org)
  • The metabolite of vitamin D, 1α,25-dihydroxyvitamin D 3 (also known as calcitriol), is a biologically active molecule required to maintain the physiological functions of several target tissues in the human body from conception to adulthood. (mdpi.com)
  • In vitro and in vivo studies demonstrate a role for vitamin D (calcitriol) in modulating cellular growth and development. (mdpi.com)
  • Vitamin D (calcitriol) acts as an antiproliferative agent in many tissues and significantly slows malignant cellular growth. (mdpi.com)
  • DBP also transports vitamin D and calcitriol. (nap.edu)
  • Following its synthesis in the kidney, calcitriol binds to DBP to be transported to target organs. (nap.edu)
  • The biological actions of calcitriol, involve regulation of gene expression at the transcriptional level, and are mediated through binding to a vitamin D receptor (VDR), located primarily in the nuclei of target cells (Jones et al. (nap.edu)
  • The classical actions of vitamin D-which by itself is inactive-are due to the functions of the active metabolite, calcitriol. (nap.edu)
  • The radioiodine-labeled protein retained its ability to bind vitamin D sterols and its physicochemical properties. (jci.org)
  • The molar excess of DBP to 25(OH)D3 in plasma, and the relatively rapid turnover of DBP indicate that a high capacity, high affinity, and dynamic transport mechanism for vitamin D sterols exists in rabbit plasma. (jci.org)
  • Vitamin D, also known as calciferol, comprises a group of fat-soluble seco-sterols. (nap.edu)
  • Genetic variations, called single nucleotide polymorphisms, are common in almost every protein involved with D, including the vitamin D receptor. (vitamindcouncil.org)
  • DBP associates with membrane-bound immunoglobulin on the surface of B-lymphocytes and with IgG Fc receptor on the membranes of T-lymphocytes. (abcam.com)
  • Potential relationship of vitamin D, vitamin D receptor (VDR), and vitamin D binding protein (DBP) have been suggested in the pathophysiology of hepatitis C virus (HCV) infection. (cdc.gov)
  • In presence of vitamin D receptor (VDR), DBP promoted cell aggression (invasion and doubling time) via activation of the insulin-like growth factor-1/insulin-like growth factor-binding protein-2/Akt axis, and induced suppression of vitamin D-responsive genes. (ncku.edu.tw)
  • To identify valid predictors of TNF-α antagonist response in RA, serum proteome profiles from responders (R) and non-responders (NR) to etanercept, a soluble recombinant TNF-α receptor/IgG Fc fusion protein receptor, were compared in a prospective cohort study. (biomedcentral.com)
  • Cross talk between signaling and vitamin A transport by the retinol-binding protein receptor STRA6. (ebi.ac.uk)
  • As Gc protein-derived macrophage activating factor it is a Macrophage Activating Factor (MAF) that has been tested for use as a cancer treatment that would activate macrophages against cancer cells. (wikipedia.org)
  • This deglycosylated Gc protein, lacking the N-acetylgalactosamine monosaccharide, cannot be converted to its form of Macrophage Activating Factor, leading to immunosuppression rather than Macrophage activation against cancer cells. (clinicaltrials.gov)
  • Efranat has developed cancer immunotherapy based on Macrophage Activating Factor produced from natural Gc protein extracted from FDA approved healthy human plasma. (clinicaltrials.gov)
  • Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. (uniprot.org)
  • ABC transporter, vitamin B12-binding protein / ABC transporter periplasmic binding domain / Periplasmic binding protein / Iron siderophore/cobalamin periplasmic-binding domain profile. (pdbj.org)
  • Structural basis of nanobody-mediated blocking of BtuF, the cognate substrate-binding protein of the Escherichia coli vitamin B12 transporter BtuCD. (pdbj.org)
  • These data point to a potential nexus between endocannabinoids, vitamin D and its transporter proteins, and the immune dysregulations observed with autism. (prweb.com)
  • The role of purpurin as a trophic factor, mediating both cell adhesion and survival, seems clear but it may also have a subsidiary role as a minor retinol transporter in the retina based on its retinol binding capacity [ PMID: 3652208 ]. (ebi.ac.uk)
  • We have studied inheritance of a polymorphism of the GC gene, rs2282679, coding for the vitamin D-binding protein, which is associated with lower serum levels of vitamin D, in a meta-analysis of 3137 melanoma patients. (lu.se)
  • Using polyacrylamide-gel isoelectric focusing followed by immunoblotting, genetic polymorphism of plasma vitamin D-binding protein (Gc) was examined in Asian sheep. (koreascience.or.kr)
  • Objective To discuss the correlation between the effect of vitamin D treatment and vitamin D binding protein gene polymorphism in elderly patients with stable chronic obstructive pulmonary disease ( COPD ). (bvsalud.org)
  • Milk from the 2 buffalo breeds contained more specific binders than vitamin B 12 , and the surplus proteins included the unsaturated TC ≈ 3 nM (Indian stock), or both TC ≈ 4 nM and HC ≈ 23 nM (Italian stock). (au.dk)
  • This enhancing activity was not due to a nonspecific effect of anionic proteins since other purified serum proteins, of similar size and charge as Gc-globulin (alpha 1 acid glycoprotein, alpha 2 HS glycoprotein, alpha 2 histidine-rich glycoprotein), could not increase the chemotactic activity of C5a des Arg. (nih.gov)
  • In Cyprinus carpio, pRBP is N-glycosylated and it has been suggested that pRBP filtration through kidney glomeruli may be reduced by a glycosylation-dependent increase in the molecular size and negative charge of the protein, since kidney filtration of anionic proteins is less than half that of neutral protein of the same size [ PMID: 11278316 ]. (ebi.ac.uk)
  • We have recently reported molecular cloning of the cDNA synthesized from rat duodenal mRNA-encoding intestinal calcium-binding protein (ICaBP), a vitamin D 3 -induced protein (Desplan, C., Thomasset, M., and Moukhtar, M.S. (1983) J. Biol. (nyu.edu)
  • It has been demonstrated that the binding and uptake of DBP by neutrophils is temporally correlated with generation of cochemotactic activity, and prevention of cellular uptake by an Ab (DBP pretreated with polyclonal anti-DBP) also precludes formation of cochemotactic activity ( 29 ). (jimmunol.org)
  • Minor changes in the chemical structure of vitamins can cause major differences in their binding to proteins and therefore in their biological function. (ecampus.com)
  • p>This section provides any useful information about the protein, mostly biological knowledge. (uniprot.org)
  • It should be noted that free vitamin D, although it constitutes only a small percentage (0.1-2%) of the total vitamin in all forms in the human body, is characterized by high biological activity (in accordance with the "free hormone hypothesis", only unbound molecules can freely migrate through cell membranes and cause particular metabolic effects) [7]. (termedia.pl)
  • There are eight naturally occurring homologues of vitamin E that differ in their structure and in biological activity in vivo and in vitro. (elsevier.com)
  • Vitamin C functions as a cofactor in many enzymatic reactions in animals (and humans) that mediate a variety of essential biological functions, including wound healing and collagen synthesis. (wikipedia.org)
  • Vitamins are essential micronutrients possessing a diverse chemical nature required by humans. (ecampus.com)
  • Vitamin D-binding protein (DBP), also/originally known as gc-globulin (group-specific component), is a protein that in humans is encoded by the GC gene. (wikipedia.org)
  • Vitamin D-binding protein also known as gc-globulin is a protein that in humans is encoded by the GC gene. (definitions.net)
  • Vitamin C is an essential nutrient for certain animals including humans. (wikipedia.org)
  • In humans, vitamin D 3 , made naturally by the body following exposure to ultraviolet light, acts as an important endocrine hormone precursor. (mdpi.com)
  • Vitamin D 2 (ergocalciferol) is largely human-made and added to foods, whereas vitamin D 3 (cholecalciferol) is synthesized in the skin of humans from 7-dehydrocholesterol and is also consumed in the diet via the intake of animal-based foods. (nap.edu)
  • 2001). Experimental animal studies have indicated that vitamin D 2 is less toxic than vitamin D 3 , but this has not been demonstrated in humans. (nap.edu)
  • human) from the internal region of the Vitamin D Binding Protein sequence according to NP_000574.2. (abcam.com)
  • Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed. (uniprot.org)
  • Recombinant protein encompassing a sequence within the center region of human Vitamin D Binding Protein. (genetex.com)
  • Sequence of rat intestinal vitamin D-dependent calcium-binding protein derived from a cDNA clone. (nyu.edu)
  • Although the derived amino acid sequence for rat ICaBP differed from the bovine and porcine sequences by 16 and 14 residues, respectively, all the residues of each calcium-binding site met the proposed requirements of the 'EF hand' theory. (nyu.edu)
  • Purification, partial amino acid sequence and interaction with mammalian transthyretin of rainbow trout (Oncorhynchus mykiss) retinol-binding protein. (ebi.ac.uk)
  • A vitamin D--dependent calcium binding protein in the chick kidney that was detected by immunocytochemical techniques was localized exclusively in the distal convoluted tubule, the initial collecting tubule, and the early part of the collecting tubule. (sciencemag.org)
  • Antiserum directed against calcium-binding protein isolated from human kidneys was used for the immunofluorescent localization of calcium-binding protein in human intestine and kidney. (bmj.com)
  • In vitamin D-deficient chicks, 28-kDa CaBP mRNA was virtually undetectable in intestine, was clearly detectable in kidney, and present at the highest levels in cerebellum. (elsevier.com)
  • Pretreatment of vitamin D-deficient chicks with actinomycin D had little effect on the acute phase of the 1,25-(OH) 2 D 3 induction of 28-kDa CaBP mRNA in intestine but blunted the induction in kidney. (elsevier.com)
  • By contrast, in the kidney, cycloheximide pretreatment resulted in an increased steady-state (vitamin D-deficient) level of 28-kDa CaBP mRNA, but completely abolished the induction of 1,25-(OH) 2 D 3 . (elsevier.com)
  • A 28,000 molecular-weight (28 K) vitamin D-dependent calcium-binding protein (CaBP) was initially isolated from the chick intestine and then described in several avian tissues (eggshell gland and kidney) where it is possibly involved in the transepithelial transport of calcium. (nyu.edu)
  • In the rat the intestinal CaBP is a small protein (10,000 MW:10 K) while the predominant CaBP in the kidney and central nervous system is a larger protein (28 K) similar to the chick CaBP. (nyu.edu)
  • Retinol-binding protein: the transport protein for vitamin A in human plasma. (ebi.ac.uk)
  • Researchers may have uncovered why the HIV drug tenofovir leads to bone loss and increased parathyroid hormone, and it may have something to do with vitamin D. (vitamindcouncil.org)
  • In the Healthy Aging in Neighborhoods of Diversity across the Life Span cohort of blacks and whites (2085 participants), we measured levels of total 25-hydroxyvitamin D, vitamin D-binding protein, and parathyroid hormone as well as bone mineral density (BMD). (nih.gov)
  • Low free 25-hydroxyvitamin D and high vitamin D binding protein and parathyroid hormone in obese Caucasians. (plos.org)
  • DBP: Vitamin D-binding protein, S-PTH: serum parathyroid hormone, HRT: Estrogen hormone replacement therapy, BMI: Body mass index, CV: The coefficient of variation, BMD: Bone mineral density, DXA: Dual energy X-ray Absorptiometry, UVB: Ultraviolet B. (alliedacademies.org)
  • However, those figures are usually only based on serum 25-hydroxyvitamin D (vitamin D) concentration, regardless of serum calcium (Ca), phosphorus (P), magnesium (Mg), alkaline phosphatase (ALP), and parathyroid hormone (PTH) levels, in both pregnant women and their neonates. (biomedcentral.com)
  • The intercalated (mitochondria-rich) cells in these tubular segments were negative for the calcium binding protein. (sciencemag.org)
  • Although the primary role of vitamin D is considered to be its effect on intestinal calcium absorption, enormous variability of fractional calcium absorption in relation to 25-OHD levels exists. (clinicaltrials.gov)
  • The aggregate data suggest that the critical mechanism for the development of nutritional rickets is reduction in availability of calcium to the skeleton, which is largely determined by vitamin D status and intestinal calcium absorption. (clinicaltrials.gov)
  • 1. The rapid stimulation of intestinal Ca 2+ transport observed in vitamin D-deficient chicks after receiving 1,25-dihydroxycholecalciferol has necessitated a re-evaluation of the correlation hitherto observed between this stimulation and the induction of calcium-binding protein synthesis. (biochemj.org)
  • This is at least 2h before calcium-binding protein can be detected immunologically and 1h before synthesis of the protein begins on polyribosomes, and thus the hormone stimulates Ca 2+ transport before calcium-binding-protein biosynthesis is induced. (biochemj.org)
  • At later times after the hormone, however, when Ca 2+ transport has declined to its basal rate, the cellular content of calcium-binding protein remains elevated. (biochemj.org)
  • 3. Calcium-binding protein is synthesized on free rather than membrane-bound polyribosomes, which implies that it is an intracellular protein. (biochemj.org)
  • 4. Rachitic chicks require the presence of dietary calcium for maximum stimulation of calcium-binding protein production by cholecalciferol. (biochemj.org)
  • 5. These results suggest that calcium-binding protein is an intracellular protein, and that its synthesis may be a consequence of the raised intracellular calcium content of the intestinal epithelial cells resulting from 1,25-dihydroxycholecalciferol-stimulated Ca 2+ transport. (biochemj.org)
  • We propose that calcium-binding-protein synthesis is necessary for maintaining the stimulated rate of Ca 2+ transport, which is initiated by other factors. (biochemj.org)
  • Vitamin D is responsible for regulating the expression of many genes (at the level of transcription or by membrane receptors) that are mainly associated with the homeostasis of calcium and phosphate, carbohydrates, and lipids, as well as with the immune response or anticancer activity [2]. (termedia.pl)
  • Effect of feeding 25-hydroxyvitamin D3 with a negative cation-anion difference diet on calcium and vitamin D status of periparturient cows and their calves. (semanticscholar.org)
  • We have studied the regulation, by 1,25-dihydroxyvitamin D 3 (1,25-(OH) 2 D 3 ), of vitamin D-dependent calcium-binding protein (28-kDa CaBP) mRNA in chick tissues in vivo. (elsevier.com)
  • Based upon the number of their calcium-binding sites and their molecular weight, two classes of vitamin D-dependent CaBPs exist in mammals. (nyu.edu)
  • Background characteristic and total dietary intakes of vitamin D and calcium were collected. (ucc.ie)
  • Calcium-binding protein 28, or Calbindin, is a protein found within all Purkinje cells of the cerebellum and is important in the regulation of intracellular calcium levels. (macewan.ca)
  • 2011. Dietary Reference Intakes for Calcium and Vitamin D . Washington, DC: The National Academies Press. (nap.edu)
  • The vitamin D binding protein (DBP), 3 also known as Gc-globulin, is a multifunctional plasma protein that can bind several diverse ligands ( 1 , 2 ). (jimmunol.org)
  • Conclusions: Vitamin D binding protein was related to vitamin D status but was independent of, or unaffected by, age, sex, body weight, bone status or vitamin D treatment. (alliedacademies.org)
  • CONCLUSIONS: We found no association between DBP, MS, and vitamin D status within the physiological range. (maastrichtuniversity.nl)
  • Blinded analyses of the concentrations of binding proteins for retinol and retinoic acid (CRABP) in homogenates of cancer and normal tissue aliquots obtained from human cervix, endometrium, ovary, breast, and lung were carried out by the sucrose gradient ultracentrifugation technique. (aacrjournals.org)
  • In contrast, cellular retinol-binding protein concentrations were reduced in the endometrial, ovarian, breast, and lung carcinomas compared to normal tissues. (aacrjournals.org)
  • Retinol (vitamin A) and retinol-binding protein levels are decreased in ankylosing spondylitis: clinical and genetic analysis. (jrheum.org)
  • Proteins in this family include plasma retinol binding protein (pRBP) and purpurin. (ebi.ac.uk)
  • Binding to RBP allows the hydrophobic vitamin to circulate in blood, but retinol dissociates from the protein prior to entering target cells [ PMID: 22665496 ]. (ebi.ac.uk)
  • Retinol circulates in the plasma without significant loss because it is bound to pRBP. (ebi.ac.uk)
  • This protein is synthesized primarily in the liver, where it requires the binding of retinol to trigger its secretion [ PMID: 6682115 ]. (ebi.ac.uk)
  • Studies on the interaction between prealbumin, retinol-binding protein, and vitamin A. J. Biol. (ebi.ac.uk)
  • Ligand-dependent regulation of intracellular protein transport: effect of vitamin a on the secretion of the retinol-binding protein. (ebi.ac.uk)
  • The piscine plasma retinol-binding protein. (ebi.ac.uk)
  • Unique biochemical nature of carp retinol-binding protein. (ebi.ac.uk)
  • In this review, the structure and function of the Gc protein is focused on especially with regard to Gc genotyping and GcMAF precursor activity. (iiarjournals.org)
  • In a landmark study published this month in the Journal of Neuroinflammation , the research team of Professors Sinascalco and Bradstreet discovered a link between the endocannabinoid system and the vitamin D binding protein, GcMAF. (prweb.com)
  • The authors state: 'This study presents the first observations of GcMAF effects on the transcriptionomics of the endocannabinoid system and expression of CB2R protein. (prweb.com)
  • GcMAF is an essential human protein our bodies make to destroy cancer. (lyranara.me)
  • GcMAf the vitamin D binding protein destroying cancer at any stage and any other condition affected your immune system that's 100% of illnesses! (mothernatureandyou.org)
  • it binds water, cations (such as Ca 2+ , Na + and K + ), fatty acids, hormones, bilirubin and drugs - its main function is to regulate the colloidal osmotic pressure of blood. (ebi.ac.uk)
  • Alphafeto- protein (alpha-fetoglobulin) is a foetal plasma protein that binds various cations, fatty acids and bilirubin. (ebi.ac.uk)
  • Studies on immunoreactivity and ligand specificity of the protein suggest that it is not a fatty acid-binding protein. (elsevier.com)
  • Dakshinamurti, K. and Chauhan, J. (1994) Biotin-Binding Proteins. (oalib.com)
  • 2. The maximum increase in Ca 2+ transport observed after this dose of 1,25-dihydroxycholecalciferol (attained by 8h) is similar to that observed after 1.25-25μg of cholecalciferol, but the stimulation is only short-lived, in contrast with the effect observed after the vitamin. (biochemj.org)
  • In chronic obstructive pulmonary disease (COPD), the blood vitamin D3 level is generally low, and genetic polymorphisms of vitamin D-binding protein encoded by the GC gene are associated with COPD development. (dovepress.com)
  • Background Vitamin D-binding protein (DBP) genetic polymorphisms have been associated with chronic obstructive pulmonary disease (COPD). (bmj.com)
  • Genetic polymorphisms independently appeared to explain 79.4% and 9.9% of the variation in levels of vitamin D-binding protein and total 25-hydroxyvitamin D, respectively. (nih.gov)
  • Community-dwelling black Americans, as compared with whites, had low levels of total 25-hydroxyvitamin D and vitamin D-binding protein, resulting in similar concentrations of estimated bioavailable 25-hydroxyvitamin D. Racial differences in the prevalence of common genetic polymorphisms provide a likely explanation for this observation. (nih.gov)
  • In molecular biology, Vitamin D binding protein domain III protein domain is predominantly found in Vitamin D binding proteins (DBP). (wikipedia.org)
  • The protein is synthesized predominantly by hepatocytes and circulates in blood at a concentration of 6-7 μM as a single polypeptide chain with a molecular mass of ∼56 kDa ( 1 ). (jimmunol.org)
  • The 2 vitamin B 12 -specific proteins, predominantly transcobalamin (TC) and haptocorrin (HC), were earlier found in milk from Holstein Friesian cows and in human or sow milk, respectively. (au.dk)
  • Tom Weishaar provides an overview from a new randomized controlled trial and discusses the importance of vitamin D-binding protein in a clinical setting. (vitamindcouncil.org)
  • Hierarchical clustering based on theexpression levels of a previously selected set of 40 proteins matchedacross the three clinical subgroups segregates the extended oligoarticularpatients. (ulster.ac.uk)
  • Genotypes of vitamin-D-binding protein (DBP) in patients with chronic obstructive pulmonary disease and healthy population of Republic Bashkortostan]. (lsh.is)
  • Association of vitamin D-binding protein variants with chronic obstructive pulmonary disease: a meta-analysis. (lsh.is)
  • Dual role of vitamin D-binding protein 1F allele in chronic obstructive pulmonary disease susceptibility: a meta-analysis. (lsh.is)
  • The protein variant in dark-skinned people, with higher affinity for S-25(OH)D, is associated with low levels of vitamin D and DBP. (alliedacademies.org)
  • On the contrary, the DBP in light-skinned people has lower affinity for S-25(OH)D and has been shown to be associated with high values of vitamin D [ 5 , 6 ]. (alliedacademies.org)
  • Recent studies suggested that modification of the membrane contact site of vitamin K-dependent proteins may enhance the membrane affinity and function of members of this protein family. (umn.edu)
  • Vitamin D binding protein (DBP) was isolated from horse plasma in a four-step procedure that involved Affi-Gel Blue affinity chromatography, gel filtration, hydroxylapatite chromatography, and anion exchange high-pressure liquid chromatography. (elsevier.com)
  • At least one labeled binding material which is also specific to an epitope, or other specific high affinity binding site on the target analyte is added to the sample so as to form labeled binding material/analyte/body complexes in the sample. (google.com.au)
  • Osteocalcin is an abundant Ca2+-binding protein indigenous to the organic matrix of bone, dentin, and possibly other mineralized tissues. (nih.gov)
  • The vitamin-K-dependent biosynthesis of osteocalcin occurs in bone, and the protein is not homologous to the Gla-containing regions of known vitamin-K-dependent blood coagulation proteins. (nih.gov)
  • Vitamin D is a fat-soluble vitamin that is essential for bone health. (nist.gov)
  • 3 Furthermore, the progressive impairment of multiple organ systems (sensory organs, endocrine and immune systems, bone marrow, skin, and mucosae) associated with the worsening of vitamin A status can be misdiagnosed as other more common pathologic conditions, 8 thus potentially contributing to delayed diagnosis and treatment. (aappublications.org)
  • The protein isoform has been associated with decreased bone mineral density (BMD) and increased fracture risk. (ucc.ie)
  • Bischoff-Ferrari HA, Dietrich T, Orav EJ, Dawson-Hughes B. Positive association between 25-hydroxy vitamin D levels and bone mineral density: a population-based study of younger and older adults. (springer.com)
  • IMSEAR at SEARO: Folic acid, vitamin B12 and vitamin B12 binding proteins in patients with neuroblastoma. (who.int)
  • We discovered that a homolog of GMFβ in human plasma is vitamin D-binding protein (DBP) and validated this finding using immunoprecipitation with anti-DBP antibodies and mass spectrometry/sequencing analysis. (lancs.ac.uk)
  • Monoclonal antibodies are capable recognizing all the fractions of Vitamin D BP. (panlaboratories.com)
  • Specific antibodies wereused to validate putative biomarker expression in synovial fluid bywestern immunoblotting and in synovial membrane (SM) byimmunohistochemistry.Results: Samespots software analysis of SF gel scans was used tohighlight joint-specific proteins which were differentially expressedacross disease classifications. (ulster.ac.uk)
  • c) a quantity of labeled antibodies or other binding material for placement in the tube, said labeled antibodies or other binding material being specific to a second epitope or other binding site on the target analyte. (google.com.au)
  • To assess the change in serum levels of protein biomarkers in the blood. (clinicaltrials.gov)
  • RESULTS: DBP-concentration did not differ between the sub-groups measured, and there was no correlation between DBP and vitamin D metabolite concentration within the physiological range. (maastrichtuniversity.nl)
  • These properties may have evolved to stabilize and maintain serum levels of vitamin D in environments with variable vitamin D availability. (jci.org)
  • High serum levels of vitamin D binding protein (DBP) are associated with an increased risk of renal cell carcinoma (RCC), according to a new study. (renalandurologynews.com)
  • DBP markedly prolonged the serum half-life of 25(OH)D and less dramatically prolonged the half-life of vitamin D by slowing its hepatic uptake and increasing the efficiency of its conversion to 25(OH)D in the liver. (jci.org)
  • Vitamin D-binding protein (DBP)(also referred to as Gc-globulin) is synthesized primarily in the liver. (wikipedia.org)
  • Vitamin D binding protein determination is useful in Determining the bioavailable vitamin D (25 hydroxy as well as 1, 25 di hydroxyl vitamin D) Determining the changes in liver failure, type I diabetes, cystic fibrosis and in pregnancy. (panlaboratories.com)
  • A 30 kDa alpha-tocopherol-binding protein in the liver cytoplasm may regulate plasma vitamin E concentrations by preferentially incorporating the vitamin E homologue, RRR-alpha-tocopherol (alpha-tocopherol), into nascent very low density lipoproteins. (elsevier.com)
  • We have identified a new alpha-tocopherol-binding protein of molecular mass 14.2 kDa in the cytosol of heart and liver This protein specifically binds alpha-tocopherol in preference to the delta- and gamma-homologues but does not bind oleate. (elsevier.com)
  • Mellanby [ 5 ] and McCollum [ 6 ] first identified vitamin D's effects in experiments that investigated the chemical components of cod liver oil that could prevent rickets in animals. (mdpi.com)
  • In this study, we examined the relationship between GC polymorphisms and plasma vitamin D3 level in Korean patients with COPD. (dovepress.com)
  • We genotyped study participants for two common polymorphisms in the vitamin D-binding protein gene (rs7041 and rs4588). (nih.gov)
  • However, the association between single nucleotide polymorphisms (SNPs) in vitamin D metabolic pathway genes and 25-hydroxyvitamin D (25(OH)D) concentration among Chinese pregnant women is seldom reported. (cdc.gov)
  • This protein contains 47-50 amino acid residues (molecular weight 5,200-5,900) depending on the species. (nih.gov)
  • Lee Biosolutions is the leading supplier of Vitamin D-Binding Protein from human plasma for removal of Vitamin D from base matrices, IVD manufacturing and research uses. (leebio.com)
  • The goal of the present paper was to characterize the biochemical properties of the putative DBP binding site on human neutrophils. (jimmunol.org)
  • Recently, attention has been paid to the presence in the human body of various forms of vitamin D and their participation in the etiology of civilization-related diseases. (termedia.pl)
  • Several forms of vitamin D can be distinguished in the human body. (termedia.pl)
  • Background: Haptocorrin is a vitamin B12-binding protein present in high amounts in different body fluids including human milk. (dtu.dk)
  • Relationships among vitamin D, 25-hydroxyvitamin D, and vitamin D-binding protein concentrations in the plasma and milk of human subjects. (semanticscholar.org)
  • Vitamin D content in human breast milk: a 9-mo follow-up study. (semanticscholar.org)
  • We tested (in vitro) the transfer of vitamin B 12 from milk proteins to human carriers, involved in the intestinal uptake. (au.dk)
  • Transfer of vitamin B 12 from the precipitated bovine casein (pH 2) to human carriers proceeded with τ 1/2 ≈ 7 min (37°C) and τ 1/2 ≈ 35 min (20°C). Liberation of vitamin B 12 from buffalo HC was hampered because of its pH stability and slow proteolysis. (au.dk)
  • The substitution of HC by less sturdy carriers is apparently more beneficial to human consumers as far as vitamin B 12 bioavailability is concerned. (au.dk)
  • Vitamins and minerals are crucial for human health. (intechopen.com)
  • A unique aspect of vitamin D as a nutrient is that it can be synthesized by the human body through the action of sunlight. (nap.edu)
  • Vitamin D-binding protein (DBP) is the primary carrier of vitamin D in the circulation and regulates the bioavailability of 25-hydroxyvitamin D. Epidemiologic studies have shown direct DBP-risk relations and modification by DBP of vitamin D-disease associations. (elsevier.com)
  • C (FokI) and carrier globulin/binding protein (GC)-rs4588 and rs7041 and the haplotype bAt [CCA]. (cdc.gov)
  • it circulates bound to a specific plasma carrier protein, vitamin D binding protein (DBP). (nap.edu)
  • In the present study, the relationship between serum DBP, lipoprotein fractions and vitamin D is investigated.METHODS: The presence of DBP in lipoprotein fractions was examined using precipitation, gel permeation chromatography and ultracentrifugation. (ugent.be)
  • There are different methods used to find the vitamins in nutrients and samples. (oalib.com)
  • The NIST Food Protein Allergen Program is focused on providing reference materials and methods to improve the connection between the measured protein food. (nist.gov)
  • Theability to distinguish patients at risk of disease extension by a selectgroup of proteins was illustrated by multivariate analysis methods.Proteins over expressed with a two-fold difference between patientsubgroups were identified by MALDI-TOF. (ulster.ac.uk)
  • The AOAC methods for vitamin D amount in fortified foods must be applied. (intechopen.com)
  • To determine longitudinally the relationship between serum 25-hydroxyvitamin D (vitamin D) and vitamin D-binding protein (DBP) levels in mother-neonate pairs and evaluate the efficiency of prophylactic vitamin D on lactation days 45-60. (biomedcentral.com)
  • The high DBP concentration under estrogenic effects in pregnancy may be responsible for low vitamin D concentrations in both pregnant women and their neonates because it binds to vitamin D. To our knowledge, no previous longitudinal study has investigated the relationship between serum vitamin D and DBP in mothers and their neonates during the lactation period. (biomedcentral.com)
  • Therefore, the goal of the present study was to assess the relationship between serum vitamin D and DBP levels in both mothers and their neonates and evaluate the effectiveness of prophylactic vitamin D at lactation days 45-60. (biomedcentral.com)
  • There was no relationship between serum vitamin B12 levels and hemoglobin, hematocrit or white cells. (who.int)
  • They produce 6 main haplotypes and 3 main protein variants (Gc1S, Gc1F and Gc2). (wikipedia.org)
  • Sections of femurs from age- and sex-matched groups of vitamin D-deficient (vitamin D − ) DBP +/+ and DBP -/- mice were stained with Masson's trichrome. (jci.org)
  • 5 years of age are vitamin A (VA) deficient, and about 2% of all deaths are attributable to VAD in this age group [ 2 ]. (mdpi.com)
  • We measured plasma and milk concentrations of vitamin D2, vitamin D3, 25-hydroxyvitamin D2 (25OHD2), 25-hydroxyvitamin D3 (25OHD3), and vitamin D-binding protein (DBP) in a group of lactating women. (semanticscholar.org)
  • Danish cow milk contained half as much TC as vitamin B 12 , and the surplus vitamin was all attached via a single coordination bond to abundantly available histidine residues of casein. (au.dk)
  • Radiolabeled DBP binds to and remains associated with the plasma membrane and is not degraded. (jimmunol.org)
  • DBP bound to the plasma membrane of neutrophils appears to play an essential role in enhancing chemotaxis to C5-derived peptides ( 28 , 29 ). (jimmunol.org)
  • Among the genes affected by environmental factors are those associated with vitamin D binding protein (DBP). (biomedcentral.com)
  • Fedosov, SN , Nexo, E & Heegaard, CW 2019, ' Vitamin B 12 and its binding proteins in milk from cow and buffalo in relation to bioavailability of B 12 ', Journal of Dairy Science , bind 102, nr. 6, s. 4891-4905. (au.dk)
  • As the type of vitamin B 12 binders may influence bioavailability of the vitamin, we examined vitamin B 12 carriers in pooled milk specimens derived from European and Indian cow and buffalo herds. (au.dk)
  • Multifunctional protein found in plasma, ascitic fluid, cerebrospinal fluid, and urine and on the surface of many cell types. (abcam.com)
  • We investigated the possibility that the multifunctional serum protein Gc-globulin (vitamin D-binding protein) may also enhance the neutrophil chemotactic activity of complement-derived peptides. (nih.gov)
  • The vitamin D binding protein (DBP) is a multifunctional plasma protein that can modulate certain immune and inflammatory responses. (jimmunol.org)
  • Vitamin D-binding protein (DBP) is a multifunctional and highly expressed plasma protein. (biomedcentral.com)