Insertion of viral DNA into host-cell DNA. This includes integration of phage DNA into bacterial DNA; (LYSOGENY); to form a PROPHAGE or integration of retroviral DNA into cellular DNA to form a PROVIRUS.
A member of the c-ets family of transcription factors that is preferentially expressed in cells of hematopoietic lineages and vascular endothelial cells. It was originally identified as a protein that provides a retroviral integration site for integration of FRIEND MURINE LEUKEMIA VIRUS.
Species of GAMMARETROVIRUS, containing many well-defined strains, producing leukemia in mice. Disease is commonly induced by injecting filtrates of propagable tumors into newborn mice.
Deoxyribonucleic acid that makes up the genetic material of viruses.
Recombinases that insert exogenous DNA into the host genome. Examples include proteins encoded by the POL GENE of RETROVIRIDAE and also by temperate BACTERIOPHAGES, the best known being BACTERIOPHAGE LAMBDA.
A strain of Murine leukemia virus (LEUKEMIA VIRUS, MURINE) arising during the propagation of S37 mouse sarcoma, and causing lymphoid leukemia in mice. It also infects rats and newborn hamsters. It is apparently transmitted to embryos in utero and to newborns through mother's milk.
Duplex DNA sequences in eukaryotic chromosomes, corresponding to the genome of a virus, that are transmitted from one cell generation to the next without causing lysis of the host. Proviruses are often associated with neoplastic cell transformation and are key features of retrovirus biology.
Normal cellular genes homologous to viral oncogenes. The products of proto-oncogenes are important regulators of biological processes and appear to be involved in the events that serve to maintain the ordered procession through the cell cycle. Proto-oncogenes have names of the form c-onc.
The type species of the genus ORTHOHEPADNAVIRUS which causes human HEPATITIS B and is also apparently a causal agent in human HEPATOCELLULAR CARCINOMA. The Dane particle is an intact hepatitis virion, named after its discoverer. Non-infectious spherical and tubular particles are also seen in the serum.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
Viruses whose genetic material is RNA.
An inheritable change in cells manifested by changes in cell division and growth and alterations in cell surface properties. It is induced by infection with a transforming virus.
A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.
The type species of ORTHOPOXVIRUS, related to COWPOX VIRUS, but whose true origin is unknown. It has been used as a live vaccine against SMALLPOX. It is also used as a vector for inserting foreign DNA into animals. Rabbitpox virus is a subspecies of VACCINIA VIRUS.
Established cell cultures that have the potential to propagate indefinitely.
The process of intracellular viral multiplication, consisting of the synthesis of PROTEINS; NUCLEIC ACIDS; and sometimes LIPIDS, and their assembly into a new infectious particle.
Specific molecular components of the cell capable of recognizing and interacting with a virus, and which, after binding it, are capable of generating some signal that initiates the chain of events leading to the biological response.
Process of growing viruses in live animals, plants, or cultured cells.
The insertion of recombinant DNA molecules from prokaryotic and/or eukaryotic sources into a replicating vehicle, such as a plasmid or virus vector, and the introduction of the resultant hybrid molecules into recipient cells without altering the viability of those cells.
Tumors or cancer of the LIVER.
The expelling of virus particles from the body. Important routes include the respiratory tract, genital tract, and intestinal tract. Virus shedding is an important means of vertical transmission (INFECTIOUS DISEASE TRANSMISSION, VERTICAL).
A species of POLYOMAVIRUS originally isolated from Rhesus monkey kidney tissue. It produces malignancy in human and newborn hamster kidney cell cultures.
A general term for diseases produced by viruses.
The assembly of VIRAL STRUCTURAL PROTEINS and nucleic acid (VIRAL DNA or VIRAL RNA) to form a VIRUS PARTICLE.
Viruses parasitic on plants higher than bacteria.
Viruses whose nucleic acid is DNA.
Viruses which lack a complete genome so that they cannot completely replicate or cannot form a protein coat. Some are host-dependent defectives, meaning they can replicate only in cell systems which provide the particular genetic function which they lack. Others, called SATELLITE VIRUSES, are able to replicate only when their genetic defect is complemented by a helper virus.
The procedures involved in combining separately developed modules, components, or subsystems so that they work together as a complete system. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
The type species of ALPHAVIRUS normally transmitted to birds by CULEX mosquitoes in Egypt, South Africa, India, Malaya, the Philippines, and Australia. It may be associated with fever in humans. Serotypes (differing by less than 17% in nucleotide sequence) include Babanki, Kyzylagach, and Ockelbo viruses.
The type species of MORBILLIVIRUS and the cause of the highly infectious human disease MEASLES, which affects mostly children.
A subtype of INFLUENZA A VIRUS with the surface proteins hemagglutinin 1 and neuraminidase 1. The H1N1 subtype was responsible for the Spanish flu pandemic of 1918.
The type species of LYSSAVIRUS causing rabies in humans and other animals. Transmission is mostly by animal bites through saliva. The virus is neurotropic multiplying in neurons and myotubes of vertebrates.
A subtype of INFLUENZA A VIRUS comprised of the surface proteins hemagglutinin 5 and neuraminidase 1. The H5N1 subtype, frequently referred to as the bird flu virus, is endemic in wild birds and very contagious among both domestic (POULTRY) and wild birds. It does not usually infect humans, but some cases have been reported.
A subtype of INFLUENZA A VIRUS comprised of the surface proteins hemagglutinin 3 and neuraminidase 2. The H3N2 subtype was responsible for the Hong Kong flu pandemic of 1968.
A species of FLAVIVIRUS, one of the Japanese encephalitis virus group (ENCEPHALITIS VIRUSES, JAPANESE). It can infect birds and mammals. In humans, it is seen most frequently in Africa, Asia, and Europe presenting as a silent infection or undifferentiated fever (WEST NILE FEVER). The virus appeared in North America for the first time in 1999. It is transmitted mainly by CULEX spp mosquitoes which feed primarily on birds, but it can also be carried by the Asian Tiger mosquito, AEDES albopictus, which feeds mainly on mammals.
The functional hereditary units of VIRUSES.
A group of viruses in the PNEUMOVIRUS genus causing respiratory infections in various mammals. Humans and cattle are most affected but infections in goats and sheep have also been reported.
Ribonucleic acid that makes up the genetic material of viruses.
Proteins found in any species of virus.
The mechanism by which latent viruses, such as genetically transmitted tumor viruses (PROVIRUSES) or PROPHAGES of lysogenic bacteria, are induced to replicate and then released as infectious viruses. It may be effected by various endogenous and exogenous stimuli, including B-cell LIPOPOLYSACCHARIDES, glucocorticoid hormones, halogenated pyrimidines, IONIZING RADIATION, ultraviolet light, and superinfecting viruses.
Substances elaborated by viruses that have antigenic activity.
The ability of a pathogenic virus to lie dormant within a cell (latent infection). In eukaryotes, subsequent activation and viral replication is thought to be caused by extracellular stimulation of cellular transcription factors. Latency in bacteriophage is maintained by the expression of virally encoded repressors.
The type species of VESICULOVIRUS causing a disease symptomatically similar to FOOT-AND-MOUTH DISEASE in cattle, horses, and pigs. It may be transmitted to other species including humans, where it causes influenza-like symptoms.
Membrane glycoproteins from influenza viruses which are involved in hemagglutination, virus attachment, and envelope fusion. Fourteen distinct subtypes of HA glycoproteins and nine of NA glycoproteins have been identified from INFLUENZA A VIRUS; no subtypes have been identified for Influenza B or Influenza C viruses.
Production of new arrangements of DNA by various mechanisms such as assortment and segregation, CROSSING OVER; GENE CONVERSION; GENETIC TRANSFORMATION; GENETIC CONJUGATION; GENETIC TRANSDUCTION; or mixed infection of viruses.
DNA molecules capable of autonomous replication within a host cell and into which other DNA sequences can be inserted and thus amplified. Many are derived from PLASMIDS; BACTERIOPHAGES; or VIRUSES. They are used for transporting foreign genes into recipient cells. Genetic vectors possess a functional replicator site and contain GENETIC MARKERS to facilitate their selective recognition.
Viruses that produce tumors.
Species of the genus LENTIVIRUS, subgenus primate immunodeficiency viruses (IMMUNODEFICIENCY VIRUSES, PRIMATE), that induces acquired immunodeficiency syndrome in monkeys and apes (SAIDS). The genetic organization of SIV is virtually identical to HIV.
A CELL LINE derived from the kidney of the African green (vervet) monkey, (CERCOPITHECUS AETHIOPS) used primarily in virus replication studies and plaque assays.
A species of CERCOPITHECUS containing three subspecies: C. tantalus, C. pygerythrus, and C. sabeus. They are found in the forests and savannah of Africa. The African green monkey (C. pygerythrus) is the natural host of SIMIAN IMMUNODEFICIENCY VIRUS and is used in AIDS research.
The infective system of a virus, composed of the viral genome, a protein core, and a protein coat called a capsid, which may be naked or enclosed in a lipoprotein envelope called the peplos.
Group of alpharetroviruses (ALPHARETROVIRUS) producing sarcomata and other tumors in chickens and other fowl and also in pigeons, ducks, and RATS.
Bacterial proteins that are used by BACTERIOPHAGES to incorporate their DNA into the DNA of the "host" bacteria. They are DNA-binding proteins that function in genetic recombination as well as in transcriptional and translational regulation.
The type species of RUBULAVIRUS that causes an acute infectious disease in humans, affecting mainly children. Transmission occurs by droplet infection.
A species of RESPIROVIRUS also called hemadsorption virus 2 (HA2), which causes laryngotracheitis in humans, especially children.
Infections produced by oncogenic viruses. The infections caused by DNA viruses are less numerous but more diverse than those caused by the RNA oncogenic viruses.
Viruses which produce a mottled appearance of the leaves of plants.
The type species of ALPHARETROVIRUS producing latent or manifest lymphoid leukosis in fowl.
The relationships of groups of organisms as reflected by their genetic makeup.
A species in the genus HEPATOVIRUS containing one serotype and two strains: HUMAN HEPATITIS A VIRUS and Simian hepatitis A virus causing hepatitis in humans (HEPATITIS A) and primates, respectively.
A species of ALPHAVIRUS isolated in central, eastern, and southern Africa.
Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly.
The measurement of infection-blocking titer of ANTISERA by testing a series of dilutions for a given virus-antiserum interaction end-point, which is generally the dilution at which tissue cultures inoculated with the serum-virus mixtures demonstrate cytopathology (CPE) or the dilution at which 50% of test animals injected with serum-virus mixtures show infectivity (ID50) or die (LD50).
Method for measuring viral infectivity and multiplication in CULTURED CELLS. Clear lysed areas or plaques develop as the VIRAL PARTICLES are released from the infected cells during incubation. With some VIRUSES, the cells are killed by a cytopathic effect; with others, the infected cells are not killed but can be detected by their hemadsorptive ability. Sometimes the plaque cells contain VIRAL ANTIGENS which can be measured by IMMUNOFLUORESCENCE.
The binding of virus particles to receptors on the host cell surface. For enveloped viruses, the virion ligand is usually a surface glycoprotein as is the cellular receptor. For non-enveloped viruses, the virus CAPSID serves as the ligand.
A species of POLYOMAVIRUS apparently infecting over 90% of children but not clearly associated with any clinical illness in childhood. The virus remains latent in the body throughout life and can be reactivated under certain circumstances.
Any of the processes by which cytoplasmic factors influence the differential control of gene action in viruses.
Viruses whose taxonomic relationships have not been established.
A species of POLYOMAVIRUS, originally isolated from the brain of a patient with progressive multifocal leukoencephalopathy. The patient's initials J.C. gave the virus its name. Infection is not accompanied by any apparent illness but serious demyelinating disease can appear later, probably following reactivation of latent virus.
A family of RNA viruses causing INFLUENZA and other diseases. There are five recognized genera: INFLUENZAVIRUS A; INFLUENZAVIRUS B; INFLUENZAVIRUS C; ISAVIRUS; and THOGOTOVIRUS.
The type species of ORBIVIRUS causing a serious disease in sheep, especially lambs. It may also infect wild ruminants and other domestic animals.
Extrachromosomal, usually CIRCULAR DNA molecules that are self-replicating and transferable from one organism to another. They are found in a variety of bacterial, archaeal, fungal, algal, and plant species. They are used in GENETIC ENGINEERING as CLONING VECTORS.
Virus diseases caused by the ORTHOMYXOVIRIDAE.
A multistage process that includes cloning, physical mapping, subcloning, determination of the DNA SEQUENCE, and information analysis.
Family of RNA viruses that infects birds and mammals and encodes the enzyme reverse transcriptase. The family contains seven genera: DELTARETROVIRUS; LENTIVIRUS; RETROVIRUSES TYPE B, MAMMALIAN; ALPHARETROVIRUS; GAMMARETROVIRUS; RETROVIRUSES TYPE D; and SPUMAVIRUS. A key feature of retrovirus biology is the synthesis of a DNA copy of the genome which is integrated into cellular DNA. After integration it is sometimes not expressed but maintained in a latent state (PROVIRUSES).
In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.
The type species of RESPIROVIRUS in the subfamily PARAMYXOVIRINAE. It is the murine version of HUMAN PARAINFLUENZA VIRUS 1, distinguished by host range.
The outer protein protective shell of a virus, which protects the viral nucleic acid.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
A genus of the family HERPESVIRIDAE, subfamily ALPHAHERPESVIRINAE, consisting of herpes simplex-like viruses. The type species is HERPESVIRUS 1, HUMAN.
The type species of the FLAVIVIRUS genus. Principal vector transmission to humans is by AEDES spp. mosquitoes.
The type species of TOBAMOVIRUS which causes mosaic disease of tobacco. Transmission occurs by mechanical inoculation.
Pneumovirus infections caused by the RESPIRATORY SYNCYTIAL VIRUSES. Humans and cattle are most affected but infections in goats and sheep have been reported.
The type species of LEPORIPOXVIRUS causing infectious myxomatosis, a severe generalized disease, in rabbits. Tumors are not always present.
Inactivation of viruses by non-immune related techniques. They include extremes of pH, HEAT treatment, ultraviolet radiation, IONIZING RADIATION; DESICCATION; ANTISEPTICS; DISINFECTANTS; organic solvents, and DETERGENTS.
A species of ORTHOPOXVIRUS that is the etiologic agent of COWPOX. It is closely related to but antigenically different from VACCINIA VIRUS.
Visible morphologic changes in cells infected with viruses. It includes shutdown of cellular RNA and protein synthesis, cell fusion, release of lysosomal enzymes, changes in cell membrane permeability, diffuse changes in intracellular structures, presence of viral inclusion bodies, and chromosomal aberrations. It excludes malignant transformation, which is CELL TRANSFORMATION, VIRAL. Viral cytopathogenic effects provide a valuable method for identifying and classifying the infecting viruses.
Includes the spectrum of human immunodeficiency virus infections that range from asymptomatic seropositivity, thru AIDS-related complex (ARC), to acquired immunodeficiency syndrome (AIDS).
A species of ORTHOPOXVIRUS causing infections in humans. No infections have been reported since 1977 and the virus is now believed to be virtually extinct.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
The type species of PNEUMOVIRUS and an important cause of lower respiratory disease in infants and young children. It frequently presents with bronchitis and bronchopneumonia and is further characterized by fever, cough, dyspnea, wheezing, and pallor.
A species of ARENAVIRUS, part of the Old World Arenaviruses (ARENAVIRUSES, OLD WORLD), and the etiologic agent of LASSA FEVER. LASSA VIRUS is a common infective agent in humans in West Africa. Its natural host is the multimammate mouse Mastomys natalensis.
A subfamily in the family MURIDAE, comprising the hamsters. Four of the more common genera are Cricetus, CRICETULUS; MESOCRICETUS; and PHODOPUS.
The biosynthesis of RNA carried out on a template of DNA. The biosynthesis of DNA from an RNA template is called REVERSE TRANSCRIPTION.
The type species of LENTIVIRUS and the etiologic agent of AIDS. It is characterized by its cytopathic effect and affinity for the T4-lymphocyte.
A species of ALPHAVIRUS causing an acute dengue-like fever.
An acute viral infection in humans involving the respiratory tract. It is marked by inflammation of the NASAL MUCOSA; the PHARYNX; and conjunctiva, and by headache and severe, often generalized, myalgia.
The type species in the genus NOROVIRUS, first isolated in 1968 from the stools of school children in Norwalk, Ohio, who were suffering from GASTROENTERITIS. The virions are non-enveloped spherical particles containing a single protein. Multiple strains are named after the places where outbreaks have occurred.
A collection of single-stranded RNA viruses scattered across the Bunyaviridae, Flaviviridae, and Togaviridae families whose common property is the ability to induce encephalitic conditions in infected hosts.
Biological properties, processes, and activities of VIRUSES.
The type species of SIMPLEXVIRUS causing most forms of non-genital herpes simplex in humans. Primary infection occurs mainly in infants and young children and then the virus becomes latent in the dorsal root ganglion. It then is periodically reactivated throughout life causing mostly benign conditions.
The type species of LYMPHOCRYPTOVIRUS, subfamily GAMMAHERPESVIRINAE, infecting B-cells in humans. It is thought to be the causative agent of INFECTIOUS MONONUCLEOSIS and is strongly associated with oral hairy leukoplakia (LEUKOPLAKIA, HAIRY;), BURKITT LYMPHOMA; and other malignancies.
A species of GAMMARETROVIRUS causing leukemia, lymphosarcoma, immune deficiency, or other degenerative diseases in cats. Several cellular oncogenes confer on FeLV the ability to induce sarcomas (see also SARCOMA VIRUSES, FELINE).
Infection with human herpesvirus 4 (HERPESVIRUS 4, HUMAN); which may facilitate the development of various lymphoproliferative disorders. These include BURKITT LYMPHOMA (African type), INFECTIOUS MONONUCLEOSIS, and oral hairy leukoplakia (LEUKOPLAKIA, HAIRY).
Viral proteins that are components of the mature assembled VIRUS PARTICLES. They may include nucleocapsid core proteins (gag proteins), enzymes packaged within the virus particle (pol proteins), and membrane components (env proteins). These do not include the proteins encoded in the VIRAL GENOME that are produced in infected cells but which are not packaged in the mature virus particle,i.e. the so called non-structural proteins (VIRAL NONSTRUCTURAL PROTEINS).
Any of the viruses that cause inflammation of the liver. They include both DNA and RNA viruses as well viruses from humans and animals.
A genus of FLAVIVIRIDAE causing parenterally-transmitted HEPATITIS C which is associated with transfusions and drug abuse. Hepatitis C virus is the type species.
Proteins that form the CAPSID of VIRUSES.
The degree of pathogenicity within a group or species of microorganisms or viruses as indicated by case fatality rates and/or the ability of the organism to invade the tissues of the host. The pathogenic capacity of an organism is determined by its VIRULENCE FACTORS.
A subgroup of the genus FLAVIVIRUS that causes encephalitis and hemorrhagic fevers and is found in eastern and western Europe and the former Soviet Union. It is transmitted by TICKS and there is an associated milk-borne transmission from viremic cattle, goats, and sheep.
A species of RESPIROVIRUS frequently isolated from small children with pharyngitis, bronchitis, and pneumonia.
The first continuously cultured human malignant CELL LINE, derived from the cervical carcinoma of Henrietta Lacks. These cells are used for VIRUS CULTIVATION and antitumor drug screening assays.
The type species of APHTHOVIRUS, causing FOOT-AND-MOUTH DISEASE in cloven-hoofed animals. Several different serotypes exist.
Short sequences (generally about 10 base pairs) of DNA that are complementary to sequences of messenger RNA and allow reverse transcriptases to start copying the adjacent sequences of mRNA. Primers are used extensively in genetic and molecular biology techniques.
The type species of BETARETROVIRUS commonly latent in mice. It causes mammary adenocarcinoma in a genetically susceptible strain of mice when the appropriate hormonal influences operate.
A strain of Murine leukemia virus (LEUKEMIA VIRUS, MURINE) producing leukemia of the reticulum-cell type with massive infiltration of liver, spleen, and bone marrow. It infects DBA/2 and Swiss mice.
Specific hemagglutinin subtypes encoded by VIRUSES.
A strain of PRIMATE T-LYMPHOTROPIC VIRUS 1 isolated from mature T4 cells in patients with T-lymphoproliferation malignancies. It causes adult T-cell leukemia (LEUKEMIA-LYMPHOMA, T-CELL, ACUTE, HTLV-I-ASSOCIATED), T-cell lymphoma (LYMPHOMA, T-CELL), and is involved in mycosis fungoides, SEZARY SYNDROME and tropical spastic paraparesis (PARAPARESIS, TROPICAL SPASTIC).
A species of ARTERIVIRUS causing reproductive and respiratory disease in pigs. The European strain is called Lelystad virus. Airborne transmission is common.
Elements of limited time intervals, contributing to particular results or situations.
Specific loci on both the bacterial DNA (attB) and the phage DNA (attP) which delineate the sites where recombination takes place between them, as the phage DNA becomes integrated (inserted) into the BACTERIAL DNA during LYSOGENY.
The uptake of naked or purified DNA by CELLS, usually meaning the process as it occurs in eukaryotic cells. It is analogous to bacterial transformation (TRANSFORMATION, BACTERIAL) and both are routinely employed in GENE TRANSFER TECHNIQUES.
A genus of the family PARVOVIRIDAE, subfamily PARVOVIRINAE, which are dependent on a coinfection with helper adenoviruses or herpesviruses for their efficient replication. The type species is Adeno-associated virus 2.
Enzyme of the HUMAN IMMUNODEFICIENCY VIRUS that is required to integrate viral DNA into cellular DNA in the nucleus of a host cell. HIV integrase is a DNA nucleotidyltransferase encoded by the pol gene.
Defective viruses which can multiply only by association with a helper virus which complements the defective gene. Satellite viruses may be associated with certain plant viruses, animal viruses, or bacteriophages. They differ from satellite RNA; (RNA, SATELLITE) in that satellite viruses encode their own coat protein.
Tumor-selective, replication competent VIRUSES that have antineoplastic effects. This is achieved by producing cytotoxicity-enhancing proteins and/or eliciting an antitumor immune response. They are genetically engineered so that they can replicate in CANCER cells but not in normal cells, and are used in ONCOLYTIC VIROTHERAPY.
The type species of PARAPOXVIRUS which causes a skin infection in natural hosts, usually young sheep. Humans may contract local skin lesions by contact. The virus apparently persists in soil.
A suborder of PRIMATES consisting of six families: CEBIDAE (some New World monkeys), ATELIDAE (some New World monkeys), CERCOPITHECIDAE (Old World monkeys), HYLOBATIDAE (gibbons and siamangs), CALLITRICHINAE (marmosets and tamarins), and HOMINIDAE (humans and great apes).
A group of viruses in the genus PESTIVIRUS, causing diarrhea, fever, oral ulcerations, hemorrhagic syndrome, and various necrotic lesions among cattle and other domestic animals. The two species (genotypes), BVDV-1 and BVDV-2 , exhibit antigenic and pathological differences. The historical designation, BVDV, consisted of both (then unrecognized) genotypes.
The interactions between a host and a pathogen, usually resulting in disease.
A sequence of successive nucleotide triplets that are read as CODONS specifying AMINO ACIDS and begin with an INITIATOR CODON and end with a stop codon (CODON, TERMINATOR).
A group of replication-defective viruses, in the genus GAMMARETROVIRUS, which are capable of transforming cells, but which replicate and produce tumors only in the presence of Murine leukemia viruses (LEUKEMIA VIRUS, MURINE).
A positive-stranded RNA virus species in the genus HEPEVIRUS, causing enterically-transmitted non-A, non-B hepatitis (HEPATITIS E).
The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species.
Human immunodeficiency virus. A non-taxonomic and historical term referring to any of two species, specifically HIV-1 and/or HIV-2. Prior to 1986, this was called human T-lymphotropic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV). From 1986-1990, it was an official species called HIV. Since 1991, HIV was no longer considered an official species name; the two species were designated HIV-1 and HIV-2.
Immunoglobulins produced in response to VIRAL ANTIGENS.
An enzyme that catalyzes the hydrolysis of alpha-2,3, alpha-2,6-, and alpha-2,8-glycosidic linkages (at a decreasing rate, respectively) of terminal sialic residues in oligosaccharides, glycoproteins, glycolipids, colominic acid, and synthetic substrate. (From Enzyme Nomenclature, 1992)
Proteins found mainly in icosahedral DNA and RNA viruses. They consist of proteins directly associated with the nucleic acid inside the NUCLEOCAPSID.

Cloning and characterization of the promoter region of human telomerase reverse transcriptase gene. (1/1731)

Activation of telomerase is one of the rate-limiting steps in human cell immortalization and carcinogenesis Human telomerase is composed of at least two protein subunits and an RNA component. Regulation of expression of the catalytic subunit, human telomerase reverse transcriptase (hTERT), is suggested as the major determinant of the enzymatic activity. We report here the cloning and characterization of the 5'-regulatory region of the hTERT gene. The highly GC-rich content of the 5' end of the hTERT cDNA spans to the 5'-flanking region and intron 1, making a CpG island. A 1.7-kb DNA fragment encompassing the hTERT gene promoter was placed upstream of the luciferase reporter gene and transiently transfected into human cell lines of fibroblastic and epithelial origins that differed in their expression of the endogenous hTERT gene. Endogenous hTERT-expressing cells, but not nonexpressing cells, showed high levels of luciferase activity, suggesting that the regulation of hTERT gene expression occurs mainly at the transcriptional level. Additional luciferase assays using a series of constructs containing unidirectionally deleted fragments revealed that a 59-bp region (-208 to -150) is required for the maximal promoter activity. The region contains a potential Myc oncoprotein binding site (E-box), and cotransfection of a c-myc expression plasmid markedly enhanced the promoter activity, suggesting a role of the Myc protein in telomerase activation. Identification of the regulatory regions of the hTERT promoter sequence will be essential in understanding the molecular mechanisms of positive and negative regulation of telomerase.  (+info)

A novel Vpr peptide interactor fused to integrase (IN) restores integration activity to IN-defective HIV-1 virions. (2/1731)

A novel approach to complement human immunodeficiency virus type I (HIV-1) integrase (IN)-defective virions has been identified. The approach involves fusion of a 23-amino-acid stretch to the N-terminus of wild-type IN and coexpression of this chimera with the IN-defective proviral template in virus producing cells. The 23-amino-acid peptide represents a Vpr "interactor," referred to as the the WxxF or WF domain, which apparently leads to docking of the domain along with the fusion partner onto HIV-1 Vpr, thus permitting virion incorporation of the chimeric protein when expressed, in trans, with other viral products. Transfection of the WF-IN expression plasmid along with HIV-1 viral clones that produce Vpr, but bear an IN mutation, results in the release of a proportion of viral particles that are competent for integration. The extent of complementation was assessed using the MAGI cell assay, where integration of viral DNA results in the eventual appearance of easily visible multinucleated blue syncytia. The efficiency of dWF-IN (double copy of WF domain) complementation is not improved markedly by incorporation of a HIV-1 protease cleavage site (PR) between the dWF domain and IN (dWF-PR-IN), unlike that observed with Vpr fusions to IN. Furthermore, the ability of Vpr-PR-IN and dWF-PR-IN to complement IN-defective proviral clones, both of which bear an intervening protease cleavage site, appear comparable. Western blotting analyses using virions isolated through sucrose cushions demonstrate clearly the incorporation of the dWF-IN fusion protein into Vpr containing HIV-1 particles but not in Vpr-deficient virions. Additional Western blotting analyses indicate that all Vpr-IN and dWF-IN chimeras, with or without a PR site, are packaged into virions. The efficiency of virion incorporation of Vpr-IN and dWF-IN chimeras appears approximately comparable by Western blotting analysis. The ability of dWF-IN to complement IN-defective proviruses with efficiency similar to that of Vpr-PR-IN and dWF-PR-IN indicates that dWF-IN retains the full complement of functions necessary for integration of proviral DNA and is likely due to the benign nature of this small domain at the amino-terminus of IN.  (+info)

Analysis of the integration functions of phi304L: an integrase module among corynephages. (3/1731)

Plasmid p12929 was shown to integrate into the chromosome of Corynebacterium glutamicum RM3 and BL15. The minimal integrating fragment was subsequently defined. The arms flanking the integrated plasmid (attL and attR) were identified, allowing for the determination of the attP and the attB attachment sites. The attB site is located at the 3' end of an ORF presenting 62-78% identity with L19 ribosomal proteins. Integration in the attB site does not result in the inactivation of this gene because its end is also present on the attR arm of the integrated plasmid and is reconstituted. The minimal integrating fragment is 1663 bp long and contains two ORFs. The int ORF was identified as phi304L integrase on the basis of the amino acid homologies it shared with the tyrosine recombinases of the lambda integrase family. Moreover this integrase is highly homologous throughout its sequence with the integrase of phi16 corynephage, the percentage of identity reaching 89% at the NH2 end. The identity also extends upstream of the initiation codon, while both phages are elsewhere nonhomologous. An integrase module was proposed to explain this extensive homology.  (+info)

Integration of banana streak badnavirus into the Musa genome: molecular and cytogenetic evidence. (4/1731)

Breeding and tissue culture of certain cultivars of bananas (Musa) have led to high levels of banana streak badnavirus (BSV) infection in progeny from symptomless parents. BSV DNA hybridized to genomic DNA of one such parent, Obino l'Ewai, suggesting integration of viral sequences. Sequencing of clones of Obino l'Ewai genomic DNA revealed an interface between BSV and Musa sequences and a complex BSV integrant. In situ hybridization revealed two different BSV sequence locations in Obino l'Ewai chromosomes and a complex arrangement of BSV and Musa sequences was shown by probing stretched DNA fibers. This is the first report of integrated sequences that possibly lead to a plant pararetrovirus episomal infection by a mechanism differing markedly from animal retroviral systems.  (+info)

Evidence that badnavirus infection in Musa can originate from integrated pararetroviral sequences. (5/1731)

When some virus- and disease-free Musa spp. (banana and plantain) are propagated by tissue culture, the resulting plants develop infections with banana streak badnavirus (BSV), a pararetrovirus. In sharp contrast to the virion DNA recovered from natural infections, the virion DNA from tissue culture-associated infections of different Musa spp. was highly similar if not identical. Although BSV does not employ integration during the infection cycle, BSV DNA was found to be integrated into the Musa genome. While one integration consisted of a partial BSV genome, a second contained more than one complete genome that was almost identical to BSV recovered from tissue culture-derived plants. The arrangement of this integrated BSV DNA suggests that it can yield an infectious episomal genome via homologous recombination. This report documents the first instance of integrated DNA of a nonintegrating virus giving rise to an episomal viral infection and identifies tissue culture as a possible trigger for the infection, raising the question of whether similar activatable viral sequences exist in the genomes of other plants and animals.  (+info)

HMG protein family members stimulate human immunodeficiency virus type 1 and avian sarcoma virus concerted DNA integration in vitro. (6/1731)

We have reconstituted concerted human immunodeficiency virus type 1 (HIV-1) integration in vitro with specially designed mini-donor HIV-1 DNA, a supercoiled plasmid acceptor, purified bacterium-derived HIV-1 integrase (IN), and host HMG protein family members. This system is comparable to one previously described for avian sarcoma virus (ASV) (A. Aiyar et al., J. Virol. 70:3571-3580, 1996) that was stimulated by the presence of HMG-1. Sequence analyses of individual HIV-1 integrants showed loss of 2 bp from the ends of the donor DNA and almost exclusive 5-bp duplications of the acceptor DNA at the site of integration. All of the integrants sequenced were inserted into different sites in the acceptor. These are the features associated with integration of viral DNA in vivo. We have used the ASV and HIV-1 reconstituted systems to compare the mechanism of concerted DNA integration and examine the role of different HMG proteins in the reaction. Of the three HMG proteins examined, HMG-1, HMG-2, and HMG-I(Y), the products formed in the presence of HMG-I(Y) for both systems most closely match those observed in vivo. Further analysis of HMG-I(Y) mutants demonstrates that the stimulation of integration requires an HMG-I(Y) domain involved in DNA binding. While complexes containing HMG-I(Y), ASV IN, and donor DNA can be detected in gel shift experiments, coprecipitation experiments failed to demonstrate stable interactions between HMG-I(Y) and ASV IN or between HMG-I(Y) and HIV-1 IN.  (+info)

Dissecting the role of the N-terminal domain of human immunodeficiency virus integrase by trans-complementation analysis. (7/1731)

The human immunodeficiency virus (HIV) integrase protein (IN) catalyzes two reactions required to integrate HIV DNA into the human genome: 3' processing of the viral DNA ends and integration. IN has three domains, the N-terminal zinc-binding domain, the catalytic core, and the C-terminal SH3 domain. Previously, it was shown that IN proteins mutated in different domains could complement each other. We now report that this does not require any overlap between the two complementing proteins; an N-terminal domain, provided in trans, can restore IN activity of a mutant lacking this domain. Only the zinc-coordinating form of the N-terminal domain can efficiently restore IN activity of an N-terminal deletion mutant. This suggests that interaction between different domains of IN is needed for functional multimerization. We find that the N-terminal domain of feline immunodeficiency virus IN can support IN activity of an N-terminal deletion mutant of HIV type 2 IN. These cross-complementation experiments indicate that the N-terminal domain contributes to the recognition of specific viral DNA ends.  (+info)

Retroviral insertions in Evi12, a novel common virus integration site upstream of Tra1/Grp94, frequently coincide with insertions in the gene encoding the peripheral cannabinoid receptor Cnr2. (8/1731)

The common virus integration site (VIS) Evi11 was recently identified within the gene encoding the hematopoietic G-protein-coupled peripheral cannabinoid receptor Cnr2 (also referred to as Cb2). Here we show that Cnr2 is a frequent target (12%) for insertion of Cas-Br-M murine leukemia virus (MuLV) in primary tumors in NIH/Swiss mice. Multiple provirus insertions in Evi11 were cloned and shown to be located within the 3' untranslated region of the candidate proto-oncogene Cnr2. These results suggest that proviral insertion in the Cnr2 gene is an important step in Cas-Br-M MuLV-induced leukemogenesis in NIH/Swiss mice. To isolate Evi11/Cnr2 collaborating proto-oncogenes, we searched for novel common VISs in the Cas-Br-M MuLV-induced primary tumors and identified a novel frequent common VIS, Evi12 (14%). Interestingly, 54% of the Evi11/Cnr2-rearranged primary tumors contained insertions in Evi12 as well, which suggests cooperative action of the target genes in these two common VISs in leukemogenesis. By interspecific backcross analysis it was shown that Evi12 resides on mouse chromosome 10 in a region that shares homology with human chromosomes 12q and 19p. Sequence analysis demonstrated that Evi12 is located upstream of the gene encoding the molecular chaperone Tra1/Grp94, which was previously mapped to mouse chromosome 10 and human chromosome 12q22-24. Thus, Tra1/Grp94 is a candidate target gene for retroviral activation or inactivation in Evi12. However, Northern and Western blot analyses did not provide evidence that proviral insertion had altered the expression of Tra1/Grp94. Additional studies are required to determine whether Tra1/Grp94 or another candidate proto-oncogene in Evi12 is involved in leukemogenesis.  (+info)

TY - JOUR. T1 - Wingless-type mammary tumor virus integration site family, member 5A (Wnt5a) regulates human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein 120 (gp120)-induced expression of pro-inflammatory cytokines via the Ca2+/calmodulin-dependent protein kinase II (CaMKII) and c-Jun N-terminal kinase (JNK) signaling pathways. AU - Li, Bei. AU - Shi, Yuqiang. AU - Shu, Jianhong. AU - Gao, Junling. AU - Wu, Ping. AU - Tang, Shao Jun. PY - 2013/5/10. Y1 - 2013/5/10. N2 - Background: HIV-1 infection causes chronic neuroinflammation in the central nervous system (CNS). Results: The spinal cytokine up-regulation induced by HIV-1 gp120 protein depends on Wnt5a/CaMKII and/or Wnt5a/JNK pathways. Conclusion: gp120 stimulates cytokine expression in the spinal cord dorsal horn by activating Wnt5a signaling. Significance: The finding reveals Wnt signaling-mediated novel mechanisms by which HIV-1 may cause neuroinflammation.. AB - Background: HIV-1 infection causes chronic neuroinflammation ...
Retroviral integration depends on the interaction between intasomes, host chromatin and cellular targeting cofactors as LEDGF/p75 or BET proteins. Previous studies indicated that the retroviral integrase, by itself, may play a role in the local integration site selection within nucleosomal target DNA. We focused our study on this local association by analyzing the intrinsic properties of various retroviral intasomes to functionally accommodate different chromatin structures in the lack of other cofactors. Using in vitro conditions allowing the efficient catalysis of full site integration without these cofactors, we show that distinct retroviral integrases are not equally affected by chromatin compactness. Indeed, while PFV and MLV integration reactions are favored into dense and stable nucleosomes, HIV-1 and ASV concerted integration reactions are preferred into poorly dense chromatin regions of our nucleosomal acceptor templates. Predicted nucleosome occupancy around integration sites identified in
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Polycomb complex protein BMI-1 also known as polycomb group RING finger protein 4 (PCGF4) or RING finger protein 51 (RNF51) is a protein that in humans is encoded by the BMI1 gene (B cell-specific Moloney murine leukemia virus integration site 1). BMI1 is a polycomb ring finger oncogene. BMI1 (B lymphoma Mo-MLV insertion region 1 homolog) has been reported as an oncogene by regulating p16 and p19, which are cell cycle inhibitor genes. Bmi1 knockout in mice results in defects in hematopoiesis, skeletal patterning, neurological functions, and development of the cerebellum. Recently it has been reported BMI1 is rapidly recruited to sites of DNA damage and it sustains for over than 8h. Loss of BMI1 leads to radiation sensitive and impaired repair of DNA double-strand breaks by homologous recombination. Bmi1 is necessary for efficient self-renewing cell divisions of adult hematopoietic stem cells as well as adult peripheral and central nervous system neural stem cells. However, it is less important ...
Benbasat, J. and C. Gass 2002. Reflections on Integration, Interaction, and Community: the Science One Program and Beyond. Conservation Ecology 5(2):26. https://doi.org/10.5751/ES-00337-050226
The integrated HIV-1 provirus is transcribed into new genomic RNA, also serving as mRNA, which is in turn translated into viral proteins [2-6, 65] (Fig. 1). Although it is speculated that the integrated copies of viral DNA are the sole template for viral gene expression, there is also evidence of preintegration transcription from unintegrated DNA [5, 65] (Fig. 1). Most recently, it has been shown that the transcriptional interplay is regulated oppositely between integrated and unintegrated DNA following NF-κB pathway modulation [66]. Upon various pharmacological treatments of NF-κB pathway activation, transcription factors such as NF-κB p65 and AP-1 (cFos/cJun) binds to integrated DNA and increases its expression, though the uDNA expression is declined. On the other hand, inhibition of the NF-κB pathway supports the expression of circular uDNA, and Bcl-3 and AP-1 is associated with its LTR region [66]. However, the persistent expression of HIV-1 proteins has already been reported not only in ...
Complete information for HVBS8 gene (Uncategorized), Hepatitis B Virus Integration Site 8, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
JoVE publishes peer-reviewed scientific video protocols to accelerate biological, medical, chemical and physical research. Watch our scientific video articles.
Sensory integration activities are the lifeline to achieving maximum function in children with sensory processing disorders.An endless list of ideas and products, limited only by your imagination.
JoVE publishes peer-reviewed scientific video protocols to accelerate biological, medical, chemical and physical research. Watch our scientific video articles.
Programmable endonucleases introduce DNA breaks at specific sites, which are repaired by non-homologous end joining (NHEJ) or homology recombination (HDR). Genome editing in human lymphoid cells is challenging as these difficult-to-transfect cells may also inefficiently repair DNA by HDR. Here, we estimated efficiencies and dynamics of knockout (KO) and knockin (KI) generation in human T and B cell lines depending on repair template, target loci and types of genomic endonucleases. Using zinc finger nuclease (ZFN), we have engineered Jurkat and CEM cells with the 8.2 kb human immunodeficiency virus type 1 (HIV-1) ∆Env genome integrated at the adeno-associated virus integration site 1 (AAVS1) locus that stably produce virus particles and mediate infection upon transfection with helper vectors. Knockouts generated by ZFN or clustered regularly interspaced short palindromic repeats (CRISPR/Cas9) double nicking techniques were comparably efficient in lymphoid cells. However, unlike polyclonal ...
Metabolic functions may operate as important biophysiological mechanisms through which social relationships affect health. It is unclear how social embeddedness or the lack thereof is related to risk of metabolic dysregulation. To fill this gap we tested the effects of social integration on metabolic functions over time in a nationally representative sample of older adults in the United States and examined population heterogeneity in the effects. Using longitudinal data from 4,323 adults aged over 50 years in the Health and Retirement Study and latent growth curve models, we estimated the trajectories of social integration spanning five waves, 1998-2006, in relation to biomarkers of energy metabolism in 2006. We assessed social integration using a summary index of the number of social ties across five domains. We examined six biomarkers, including total cholesterol, high-density lipoprotein cholesterol, glycosylated hemoglobin, waist circumference, and systolic and diastolic blood pressure, and the
Metabolic functions may operate as important biophysiological mechanisms through which social relationships affect health. It is unclear how social embeddedness or the lack thereof is related to risk of metabolic dysregulation. To fill this gap we tested the effects of social integration on metabolic functions over time in a nationally representative sample of older adults in the United States and examined population heterogeneity in the effects. Using longitudinal data from 4,323 adults aged over 50 years in the Health and Retirement Study and latent growth curve models, we estimated the trajectories of social integration spanning five waves, 1998-2006, in relation to biomarkers of energy metabolism in 2006. We assessed social integration using a summary index of the number of social ties across five domains. We examined six biomarkers, including total cholesterol, high-density lipoprotein cholesterol, glycosylated hemoglobin, waist circumference, and systolic and diastolic blood pressure, and the
The product of the ecotropic virus integration site 1 (EVI1) gene, whose overexpression is associated with a poor prognosis in myeloid leukemias and some epithelial tumors, regulates gene transcription both through direct DNA binding and through modulation of the activity of other sequence specific transcription factors. Previous results from our laboratory have shown that EVI1 influenced transcription regulation in response to the myeloid differentiation inducing agent, all-trans retinoic acid (ATRA), in a dual manner: it enhanced ATRA induced transcription of the RAR gene, but repressed the ATRA induction of the EVI1 gene itself. In the present study, we asked whether EVI1 would modulate the ATRA regulation of a larger number of genes, as well as biological responses to this agent, in human myeloid cells. U937 and HL-60 cells ectopically expressing EVI1 through retroviral transduction were subjected to microarray based gene expression analysis, and to assays measuring cellular proliferation, ...
The HIV-1 capsid is involved in all infectious steps from reverse transcription to integration site selection, and is the target of multiple host cell and pharmacologic ligands. However, structural studies have been limited to capsid monomers (CA), and the mechanistic basis for how these ligands inf …
Recently, in the journal Cell, a comprehensive analysis of HIV integration sites was published and the data argues against the idea that HIV ...
TY - JOUR. T1 - Identification of novel Bach2 transcripts and protein isoforms through tagging analysis of retroviral integrations in B-cell lymphomas. AU - Liu, Jinghua. AU - Sørensen, Annette Balle. AU - Wang, Bruce. AU - Wabl, Matthias. AU - Nielsen, Anders Lade. AU - Pedersen, Finn Skou. PY - 2009. Y1 - 2009. N2 - ABSTRACT: BACKGROUND: The Bach2 gene functions as a transcriptional repressor in B-cells, showing high expression level only before the plasma cell stage. Several lines of evidence indicate that Bach2 is a B-cell specific tumor suppressor. We here address patterns of insertional mutagenesis and expression of Bach2 is a murine retroviral model of B-cell lymphoma induction. RESULTS: We report that the Bach2 gene is a target of proviral integrations in B-cell lymphomas induced by murine leukemia virus. An alternative Bach2 promoter was identified within intron 2 and this promoter was activated in one of the tumors harboring proviral integration. The alternative promoter was active in ...
In vertebrates, the nuclear pore has a maximum diameter of 120 nm. The nuclear pore can facilitate the movement of molecules smaller than 9 nm to a maximum diameter of 39 nm. This aspect of the nuclear pore is one of the three main challenges a virus must overcome in order to get its genome into the nucleus. The second problem of nuclear import involves the uncoating of the viral capsid or core. This step is crucial since premature capsid uncoating could be damaging to the viral genome. Furthermore, nucleic acids are required to have high densities and be very compact while in the nucleus. The last main issue with nuclear import has to do with the hydrophobic interactions between nucleoporins and the negatively charged nucleic acid. The HIV virus is able to overcome these challenges and infect non-differentiating cells [2]. The roles of matrix proteins (MA) and viral protein R (Vpr) in nuclear import is a controversial topic since the roles that these proteins play are still unclear. MA forms a ...
In vertebrates, the nuclear pore has a maximum diameter of 120 nm. The nuclear pore can facilitate the movement of molecules smaller than 9 nm to a maximum diameter of 39 nm. This aspect of the nuclear pore is one of the three main challenges a virus must overcome in order to get its genome into the nucleus. The second problem of nuclear import involves the uncoating of the viral capsid or core. This step is crucial since premature capsid uncoating could be damaging to the viral genome. Furthermore, nucleic acids are required to have high densities and be very compact while in the nucleus. The last main issue with nuclear import has to do with the hydrophobic interactions between nucleoporins and the negatively charged nucleic acid. The HIV virus is able to overcome these challenges and infect non-differentiating cells [2]. The roles of matrix proteins (MA) and viral protein R (Vpr) in nuclear import is a controversial topic since the roles that these proteins play are still unclear. MA forms a ...
Watch this short video tutorial to discover how DNASTARs SeqMan NGen viral host integration workflow can be used to locate retroviruses inserted in to host genetic material. This example analyzes samples from a gene therapy experiment.
Watch this short video tutorial to discover how DNASTARs SeqMan NGen viral host integration workflow can be used to locate retroviruses inserted in to host genetic material. This example analyzes samples from a gene therapy experiment.
The potential to integrate consistent associations identified from GWAS as fixed variables in GP models to improve prediction accuracy for complex traits (for example, grain yield) has not been investigated comprehensively in wheat. Here, we untangled the genetic architecture of grain yield and yield stability by haplotypes-based GWAS and epistatic scan of the genome. We then integrated robust and stable associations (and interacting loci) as fixed effects in GP models to investigate the importance of these associations in improving prediction accuracies of the said traits. We concluded that the utility of GP incorporating GWAS results is noteworthy for GY when GWAS results identify significant and robust genomic regions.
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies. ...
Cancer is a disease driven by the accumulation of genomic alterations, including the integration of exogenous DNA into the human somatic genome. We previously identified in silico evidence of DNA fragments from a Pseudomonas-like bacteria integrating into the 5′-UTR of four proto-oncogenes in stomach cancer sequencing data. The functional and biological consequences of these bacterial DNA integrations remain unknown. Modeling of these integrations suggests that the previously identified sequences cover most of the sequence flanking the junction between the bacterial and human DNA. Further examination of these reads reveals that these integrations are rich in guanine nucleotides and the integrated bacterial DNA may have complex transcript secondary structures. The models presented here lay the foundation for future experiments to test if bacterial DNA integrations alter the transcription of the human genes.
A defining feature of HIV replication is integration of the proviral cDNA into human DNA. The selection of chromosomal targets for integration is crucial for efficient viral replication, but the mechanism is poorly understood. Here we describe mapping of 524 sites of HIV cDNA integration on the huma …
Chasm Partners, an executive search firm in the healthcare technology and services space, recently convened a roundtable discussion to assess how the transformation of big data in clinical informatics provides the healthcare industry with an opportunity to gain new insights into patient care, as well as key lessons learned about artificial intelligences impact on the industry.. ...
Functional image analysis of the event-related runs was conducted using general linear model (GLM) in AFNI with the function 3dDeconvolve. The BOLD response to individual events from each stimulus condition was modeled using the sum of TENT basis functions in 3dDeconvolve, which is a piecewise linear spline function that estimates an impulse response function. The sum of 13 TENT functions was used to cover the duration of 18 s after the stimulus onset, TENT(0, 18, 13). All models were fit separately to each voxel. For each voxel within the predefined ROIs, 13 amplitudes for each stimulus condition were estimated, which were the time course of the estimate hemodynamic response function (HRF) to each condition at the 13 time points (from 0 to 18 s with the time step of 1.5 s). The mean of the first and last two time points was subtracted from each HRF to ensure that it started from and returned to approximately the same baseline level. Estimates from individual voxels were averaged within each of ...
Employing a scaffold hopping approach, a series of allosteric HIV-1 integrase (IN) inhibitors (ALLINIs) have been synthesized based on an indole scaffold. These compounds incorporate the key elements utilized in quinoline-based ALLINIs for binding to the IN dimer interface at the principal LEDGF/p75 binding pocket. The most potent of these compounds displayed good activity in the LEDGF/p75 dependent integration assay (IC50 = 4.5 mu M) and, as predicted based on the geometry of the five- versus six-membered ring, retained activity against the A128T IN mutant that confers resistance to many quinoline-based ALLINIs. (C) 2016 Elsevier Ltd. All rights reserved.
Beyond Air, Inc. (XAIR), a clinical-stage medical device and biopharmaceutical company focused on developing inhaled Nitric Oxide (NO) for the treatment of patients with respiratory conditions, including serious lung infections and pulmonary hypertension, and gaseous NO for the treatment of solid tumors, today announced that it has entered into a new common stock purchase agreement and registration rights agreement (together, the
Mr Stephen Karingi, Regional Integration Division Director of ECA, is quoted in the statement as saying: the report found that much more needs to be done to integrate regional economies to make them more resilient to shocks such as the current COVID-19 pandemic.. Overall, the Index shows that levels of integration on the continent are relatively low with an average score of 0.327 out of one.. Whereas the Index edition we are releasing today has data cut off points in 2019, the present COVID-19 pandemic has reopened the question of whether enough is being done in advancing regional integration as a means to help Africa withstand systematic shocks such as the one being experienced today.. This index is both a measurement exercise and a call to action; to build resilient economies through integration.. According to him, it will identify the solutions needed to truly build an integrated Africa. Jean-Denis Gabikini, Acting Director of the AUCs Economic Affairs Department, is quoted as ...
By Richard W. Hill, Gordon A. Wyse, Margaret Anderson. Animal body structure offers all of the branches of recent animal body structure with a powerful emphasis on integration of physiological wisdom, ecology, and evolutionary biology. Integration extends from molecules to organ platforms and from one physiological self-discipline to a different. The e-book takes a wholly clean method of each one subject. Its full-colour illustrations comprise many novel, visually powerful positive factors to aid scholars examine. all the 25 major chapters starts off with a quick animal instance to have interaction scholar curiosity and exhibit the worth of the cloth that would be realized. The publication contains 5 extra, briefer At paintings chapters that follow scholars newfound physiological wisdom to curiosity-provoking and significant subject matters, together with diving by means of marine mammals, the mechanisms of navigation, and muscle plasticity in use and disuse. The publication is dedicated to a ...
Principal Investigator:MATSUBARA Seijiro, Project Period (FY):2009-07-23 - 2014-03-31, Research Category:Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area), Project Area:Organic Synthesis based on Integration of Chemical Reactions. New Methodologies and New Materials
Principal Investigator:橋本 俊一, Project Period (FY):2009-07-23 - 2014-03-31(Estimated), Research Category:Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area), Project Area:Organic Synthesis based on Integration of Chemical Reactions. New Methodologies and New Materials
Family-school partnerships are essential for promoting students educational success and behavioral health. This presentation describes research-based partnerships, with emphasis on integration into positive behavior supports, structural elements, and an empirically supported partnership intervention.. ...
Bali said under this mission, greater focus will be laid on urban areas, to fill the gaps. This will be done through mapping of all under-served population in urban areas followed by need-based deployment of necessary staff in these areas. Mobility support to field staff for deployment to such areas in urban as well as rural areas will be provided as per the needs. All identified areas under Intensified Mission Indradhanush will be monitored by concerned nodal officers and emphasis will be given on integration of Intensified Mission Indradhanush sessions into routine immunization micro plans after completion of each round of the Mission he informed ...
BWA-MEM, is a new tool that is part of the latest version of BWA. As said Heng Li on Biostar bwa-mem can be used to identify the viral integration sites in the human genome. Here Ive used various short reads to explore how bwa maps the pairs. The sequences I used below are ...
Studies of changes in the virus and host cell upon progression from human papillomavirus (HPV) episomal infection to integration are critical to understanding HPV-related malignant transformation. However, there exist only a few in vitro models of both productive HPV infection and neoplastic progression on the same host background. We recently described a unique foreskin keratinocyte cell line (ERIN 59) that contains HPV 59 (a close relative of HPV 18). Early passages of ERIN 59 cells (passages 9-13) contained approximately 50 copies of episomes/cell, were feeder cell-dependent, and could be induced to differentiate and produce infectious virus in a simple culture system ...
Reactivation of latent viruses such as human cytomegalovirus (HCMV) after allogeneic hematopoietic stem cell transplantation (HSCT) results in high morbidity and mortality. Effective immunization against HCMV shortly after allo-HSCT is an unmet clinical need due to delayed adaptive T cell development. Donor-derived dendritic cells (DCs) have a critical participation in stimulation of naïve T cells and immune reconstitution, and therefore adoptive DC therapy could be used to protect patients after HSCT. However, previous methods for ex vivo generation of adoptive donor-derived DCs were complex and inconsistent, particularly regarding cell viability and potency after thawing. We have previously demonstrated in humanized mouse models of HSCT the proof-of-concept of a novel modality of lentivirus-induced DCs (
HPV invades the skin or mucosa by entering tiny breaks in the surface (even those not visible to the naked eye). Once inside, HPV infects host epithelial cells, tricking them into producing new viruses. In the process of normal cell replacement, the infected cells are shed, releasing viral particles. High risk strains of HPV can integrate viral DNA into the host genome, although this is not a normal part of the HPV life cycle. Viral integration may give infected host cells a selective advantage, leading to a longer infection time. The longer the infection lasts, the more time there is for cancer to develop.16. After integration, two viral genes (E6 and E7) may be over-expressed. The E6 and E7 proteins are responsible for the ability of HPV to cause cancer. The E6 and E7 proteins prevent the activity of key tumor suppressors. E6 inhibits p53, a protein that controls responses to different types of cellular stress including DNA damage and viral infection. E7 inhibits Rb, a protein that can prevent ...
Integration of retroviral DNA into the cellular genome is essential for the production of new infectious particles. A strong argument that the novel human
Can you please describe in more detail what you are missing here? The patch simply makes use of the generic helper function introduced by the two patches cited above and is therefore automatically compatible if none of the new properties is defined. The tsc2007 didnt have these features before. So what should we say about compatibility? , ,, A new feature is to introduce scaling the min/max ADC values to the screen ,, size. , , Sounds like a separate change. I have thought about that for a while, but did not find a way to separate it into two independent patches. If you can propose something, please help. , ,, This makes it possible to pre-calibrate the touch so that is (almost) ,, exactly matches the LCD pixel coordinates it is glued onto. This allows to ,, well enough operate the touch before a user space calibration step can ,, improve the precision. ,, ,, Finally, calculate_pressure has been renamed to calculate_resistance ,, because that is what it is doing. ,, ,, [1]: ...
terpenes mcat, The viral DNA is incorporated into the host genome, or if the virus is an RNA virus and possesses the enzyme reverse transcriptase, DNA is actually reverse transcribed from RNA and then incorporated into the host cell genome. When the host cell replicates its DNA, the viral DNA is replicated as well.
A powerpoint presentation (INF-ECA-PST-3013):Study project, project integration on a FPGA base board, first tests and measurements, synthesis ...
This chapter from |a href=/store/comptia-advanced-security-practitioner-casp-cas-002-9780789754011?w_ptgrevartcl=Host%2c+Storage%2c+Network%2c+and+Application+Integration+into+a+Secure+Enterprise+Architecture_2321780|CompTIA Advanced Security Practitioner (CASP) CAS-002 Cert Guide|/a| covers secure data flows to meet changing business needs, standards, interoperability issues, technical deployment models, logical deployment diagram and corresponding physical deployment diagram of all relevant devices, secure infrastructure design, storage Integration, and enterprise application integration enablers.
In this chapter we are going to be looking at various integration techniques. There are a fair number of them and some will be easier than others. The point of the chapter is to teach you these new techniques and so this chapter assumes that youve got a fairly good working knowledge of basic integration as well as substitutions with integrals. In fact, most integrals involving simple substitutions will not have any of the substitution work shown. It is going to be assumed that you can verify the substitution portion of the integration yourself.. Also, most of the integrals done in this chapter will be indefinite integrals. It is also assumed that once you can do the indefinite integrals you can also do the definite integrals and so to conserve space we concentrate mostly on indefinite integrals. There is one exception to this and that is the Trig Substitution section and in this case there are some subtleties involved with definite integrals that were going to have to watch out for. Outside ...
Are you searching for a complete PayPal integration service on your website? Look no further, Perception System provides PayPal website integration, PayPal merchant integration, etc. at affordable cost.
Study Flashcards On Neural Integration at Cram.com. Quickly memorize the terms, phrases and much more. Cram.com makes it easy to get the grade you want!
Health,Middletown CT (PRWEB) May 23 2013 Applied PilotFish Healthcare Integration a provider of middleware solutions announced today that it has added support for the Direct Protocol to its a href http://www,PilotFish,Expands,Healthcare,Integration,Capabilities,with,Support,for,the,New,Direct,Protocol,in,Its,Latest,Product,Release,medicine,medical news today,latest medical news,medical newsletters,current medical news,latest medicine news
Background. Retroviral integration into the host germline results in permanent viral colonization of vertebrate genomes. The koala retrovirus (KoRV) is currently invading the germline of the koala (Phascolarctos cinereus) and provides a unique opportunity for studying retroviral endogenization. Previous analysis of KoRV integration patterns in modern koalas demonstrate that they share integration sites primarily if they are related, indicating that the process is currently driven by vertical transmission rather than infection. However, due to methodological challenges, KoRV integrations have not been comprehensively characterized. Results. To overcome these challenges, we applied and compared three target enrichment techniques coupled with next generation sequencing (NGS) and a newly customized sequence-clustering based computational pipeline to determine the integration sites for 10 museum Queensland and New South Wales (NSW) koala samples collected between the 1870s and late 1980s. A secondary aim of
The Moloney leukemia virus integration 2 (MLVI2) locus represents a common region for proviral integration and a putative oncogene involved in the induction of thymic lymphomas in rodents. The human homolog of the MLVI2 locus has been cloned and studies have been intiated to determine its possible role in the induction and progression of human neoplasms. In this study we used a panel of human × rodent somatic cell hybrids and in situ hybridization to metaphase chromosomes to map MLVI2 to the short arm of the human chromosome 5, band p14.
This gene encodes retinoic acid receptor beta, a member of the thyroid-steroid hormone receptor superfamily of nuclear transcriptional regulators. This receptor localizes to the cytoplasm and to subnuclear compartments. It binds retinoic acid, the biologically active form of vitamin A which mediates cellular signalling in embryonic morphogenesis, cell growth and differentiation. It is thought that this protein limits growth of many cell types by regulating gene expression. The gene was first identified in a hepatocellular carcinoma where it flanks a hepatitis B virus integration site. The gene expresses at least two transcript variants; one additional transcript has been described, but its full length nature has not been determined.[1] ...
Whereas the roles of the canonical wingless-type MMTV (mouse mammary tumor virus) integration site family (WNT) signaling pathway in the regulation of ovarian follicle growth and steroidogenesis are now established, noncanonical WNT signaling in the ovary has been largely overlooked. Noncanonical WNTs, including WNT5a and WNT11, are expressed in granulosa cells (GCs) and are differentially regulated throughout follicle development, but their physiologic roles remain unknown. Using conditional gene targeting, we found that GC-specific inactivation ofWnt5a(but notWnt11) results in the female subfertility associated with increased follicular atresia and decreased rates of ovulation. Microarray analyses have revealed that WNT5a acts to down-regulate the expression of FSH-responsive genesin vitro, and corresponding increases in the expression of these genes have been found in the GCs of conditional knockout mice. Unexpectedly, we found that WNT5a regulates its target genes not by signalingviathe ...
Wingless-type mouse mammary tumor virus integration site family (WNT)/β-catenin (CTNNB1) pathway components are expressed in ovarian granulosa cells, direct female gonad development, and are regulated by the pituitary gonadotropins. However, the in vivo functions of CTNNB1 during preovulatory follicular development, ovulation, and luteinization remain unclear. Using a mouse model Ctnnb1(Ex3)fl/fl;Cyp19-Cre (Ctnnb1(Ex3)gc-/-), expressing dominant stable CTNNB1 in granulosa cells of small antral and preovulatory follicles, we show that CTNNB1 facilitates FSH-induced follicular growth and decreases the follicle atresia (granulosa cell apoptosis). At the molecular level, WNT signaling and FSH synergistically promote the expression of genes required for cell proliferation and estrogen biosynthesis, but decrease FOXO1, which negatively regulates proliferation and steroidogenesis. Conversely, dominant stable CTNNB1 represses LH-induced oocyte maturation, ovulation, luteinization, and progesterone ...
Reaktivität: Fledermaus, Cat, Huhn and more. 161 verschiedene FLI1 Antikörper vergleichen. Alle direkt auf antikörper-online bestellbar!
Named among the Best Hospitals in America by US News World Report for 19 consecutive years, Indiana University Health is Indianas most comprehensive healthcare system.
Insertional mutagenesis approaches use oncoretroviruses or transposons to trigger cancer in mice by widespread integration into the cellular genome and activation of oncogenes near the integration site. Mapping the genomic integration sites in tumors allows the identification of genomic regions that are recurrently hit in independent tumors (defined as Common Insertion Sites, CIS) (5), which host genes likely involved in cancer development (6).. We have recently developed a new specifically tailored LV-based insertional mutagen that allowed the induction of hepatocellular carcinoma in 3 different mouse models (4). In order to identify the integration sites from LV-induced tumors and control nontumoral samples, we exploited LAM-PCR (1) followed by 454 pyrosequencing. The analysis of LV integrations in tumors allowed the identification of 4 new liver cancer genes. Here we describe how we applied the LAM-PCR protocol1 for the retrieval of LV integrations from the hepatocellular carcinomas induced ...
In 2017, Ben Hodges, back then the U.S. general in charge of the U.S. military in Europe, related to the press the problems he had to deal with to tackle the Russian threats in the Old Continent. He outlined that NATO military movements were continuously hampered by red tape. The reason being was that NATO allies did not enjoy freedom of movement through their borders. Every time a military force needed to cross a border, it had to deal with the bureaucracy and laws of each country, which may be the responsibility of different ministries (not necessarily the Ministry of Defence). ...
implemented in western Kenya a few years ago. The second project is to develop and field test a toolkit designed for health facility in charges to successfully integrate family planning and HIV services. Here are the links to the positions and job descriptions are also attached:. ...
Data and research on international migration including migration stocks and flows, immigrants in the labour market, integration and discrimination., The OECD series Making Integration Work draws on key lessons from the OECDs work on integration. The objective is to summarise in a non-technical way the main challenges and good policy practices to support the lasting integration of immigrants and their children for selected key groups and domains of integration. Each volume presents ten lessons and examples of good practice, complemented by synthetic comparisons of the integration policy frameworks in OECD countries. This second volume deals with the assessment and recognition of foreign qualifications.
Thirty-four transgenic mouse strains, each carrying a single proviral insert, were generated by infection of preimplantation and postimplantation embryos with retroviruses. Animals homozygous for proviral integrations were derived for all strains with the exception of Mov 24, where the provirus is inserted on the Y chromosome, and Mov 34. Embryos homozygous at the Mov 34 locus develop normally to the blastocyst stage and die shortly after implantation, indicating that virus integration resulted in a recessive lethal mutation. The provirus and flanking sequences were cloned and the virus was mapped to the 5 side of an abundantly and ubiquitously transcribed gene. Similar to the previously derived Mov 13 mutation, proviral integration at the Mov 34 locus interferes with the expression of the adjacent gene. These and our previous results indicate that of a total of 48 proviral integrations in the germ line, two resulted in transgenic mouse strains with recessive lethal mutations.
Andrea Calì, Diego Calvanese, Giuseppe De Giacomo, and Maurizio Lenzerini Proc. of the 10th Italian Symp. on Advanced Database Systems (SEBD 2002). 2002.. Data integration systems provide access to a set of heterogeneous, autonomous data sources through a so-called global, or mediated view. There is a general consensus that the best way to describe the global view is through a conceptual data model, and that there are basically two approaches for designing a data integration system. In the global-as-view approach, one defines the concepts in the global schema as views over the sources, whereas in the local-as-view approach, one characterizes the sources as views over the global schema. It is well known that processing queries in the latter approach is similar to query answering with incomplete information, and, therefore, is a complex task. On the other hand, it is a common opinion that query processing is much easier in the former approach. In this paper we show the surprising result that, ...
Growth in the Number of Surgical Procedures is estimated to boost the Surgical Integration Systems Market Surgical integration systems are specially
Structural Integration refers to a system of body education and physical manipulation developed by Dr. Ida P. Rolf. Practitioner work with the bodys system of fascia (the supportive wrapping of muscles and other tissue), to release and free the chronic tightness, restrictions, and compensations that have built up over time. By doing so in a systematic way, the goal of Structural Integration is to balance the clients body more efficiently in gravity and allow their body to work in an easier, more natural and comfortable manner. The terms Rolfing and Structural Integration are often (and incorrectly) used interchangeably. Structural Integration (SI) is the generic term for the entire field. The terms Rolfing and Rolfer refer to graduates of the Rolf Institute of Structural Integration, which is one of several schools that teach SI.
MiR-155 is a microRNA that in humans is encoded by the MIR155 host gene or MIR155HG. MiR-155 plays a role in various physiological and pathological processes. Exogenous molecular control in vivo of miR-155 expression may inhibit malignant growth, viral infections, and enhance the progression of cardiovascular diseases. The MIR155HG was initially identified as a gene that was transcriptionally activated by promoter insertion at a common retroviral integration site in B-cell lymphomas and was formerly called BIC (B-cell Integration Cluster). It was demonstrated that miR-155 over-expression supports the development and aggresivness of B cell malignancies. The MIR155HG is transcribed by RNA polymerase II and the resulting ~1,500 nucleotide RNA is capped and polyadenylated. The 23 nucleotide single-stranded miR-155, which is harbored in exon 3, is subsequently processed from the parent RNA molecule. The MIR155HG RNA transcript does not contain a long open reading frame (ORF), however, it does include ...
Data integration is at the heart of a significant portion of current information system implementations. As companies continue to move towards a diverse, growing set of Commercial Off the Shelf (COTS) applications to fulfill their information technology needs, the need to integrate data between them continues to increase. In addition, these diverse application portfolios are becoming more geographically dispersed as more software is provided using the Software as a Service (SaaS) model, and companies continue the pattern of moving their internal data centers to cloud-based computing. As the growth of data integration activities continues, several prominent data integration patterns have emerged, and commercial software packages have been created that covers each of the patterns below: 1. Bulk and/or batch data extraction and delivery (ETL, ELT, etc.); 2. Messaging / Message-oriented data movement; 3. Granular, low-latency data capture and propagation (data synchronization). As the data ...
In their march to copy Google Chrome, Mozilla is moving Firefox to a multi-process architecture. The code name for this project is Electrolysis. As of this writing, this projects integration target for released levels of Firefox is at the end of 2015. Dates can always slip, and are likely to, but that target seems real soon now.. Frustratingly, Mozilla has been surprisingly quiet about this upcoming change, at least from a developer standpoint. For months the Mozilla Add-ons Blog has promised upcoming articles on the changes necessary for add-on authors, but as of this writing, nothing has appeared. What documentation does exist is, as usual, poorly written. The examples they provide arent real-world enough for me to fully understand.. It frightens me that Mozilla should be so lackadaisical about evangelizing these changes. This architecture shift will affect the vast majority of add-ons in one form or another. I verified tonight in a nightly build that both Googlebar Lite and CoLT are ...
Infection and replication of HIV-1 have been analysed in various tissue culture systems including primary cells. These studies mostly applied ensemble measurements, and few analyses of individual events at high spatial and temporal resolution are currently available. Cellular and viral macromolecular complexes are involved at all stages of HIV-1 replication, and many individual factors and their respective contributions have been identified. Surprisingly little is known about fundamental details of many steps in HIV-1 replication, however. Important examples include (i) virus attachment and entry at the plasma membrane or from within the endosome in different target cells, (ii) timing and mechanisms of capsid uncoating, (iii) localisation, structure and composition of the genome replication complex and its conversion into the pre-integration complex, and (iv) induction and control of innate immunity. Accordingly, the early phase is probably the most enigmatic stage of HIV-1 replication.. Within ...
The assembly of Human Immunodeficiency Virus-1 (HIV-1) is mediated by the Gag polyprotein. Located N- to C-term are the independently folded domains: matrix (MA), capsid (CA), and nucleocapsid (NC). Exposure of the N-terminal myristyl group of the HIV matrix protein is coupled with trimerization and further enhanced by the self-associating Gag subdomains. This targets the Gag polyprotein to lipid rafts in the plasma membrane during viral assembly. Subsequent to budding, proteolytic cleavage of the Gag subdomains into the structural proteins of the virus combined with infection of a host, drives the equilibrium to the monomeric species causing sequestration of the myristyl group into a cavity of the matrix with very little conformational changes. The matrix protein can then dissociate from the membrane for nuclear targeting of the pre-integration complex. Evidence of the presence of the trimeric species has been demonstrated by analytical ultracentrifugation and X-ray crystallography of isolated ...
Case studies on integration of routine vaccination and other maternal and child health services from four African countries-Kenya, Mali, Ethiopia and Cameroon-published in the Journal of Infectious Diseases. Highlights related knowledge gaps among community members and health workers.. To read the abstract and download the article, click here.. ...
Also, when you say the function is assymetric and so the areas should cancel, but since the limits of integration are infinite the function diverges. But when ∫x^3 dx we are essentially finding the area under the curve of (x^4)/4 which is an even function so the areas should not cancel because the function is symmetrical on both sides ...
The comprehensive listing of activities, duties or responsibilities that are required of the employee for this position may be in excess of what is listed herein. Duties, responsibilities and activities may change at any time with or without notice.. This position requires visual acuity and listening ability. Individuals must be able to stand, kneel and crouch for long periods of time. Individuals may be required to climb ladders and scaffolding and must be able to lift in excess of 50 pounds. This position will on occasion require individuals to work in high places and in small cramped spaces.. Individuals will be required to pass a background and drug test. A valid driver license and acceptable driving record are mandatory.. Coastal Fire and Integration Systems is an Equal Opportunity Employer. We invite all qualified applicants to apply including individuals with disabilities and protected veterans. ...
Custom integrations on Workplace are services that use the Graph API and the Account Management API to extend the functionality of Workplace.. By building a custom integration app, you can keep employee information in sync with an identity service, automate group membership, make backups of posts in groups, or automate posting to specific groups based on activity in another service.. You can also use custom integrations to build group and chat bots that can communicate in groups on Workplace and in Work Chat. ...
Custom integrations on Workplace are services that use the Graph API and the Account Management API to extend the functionality of Workplace.. By building a custom integration app, you can keep employee information in sync with an identity service, automate group membership, make backups of posts in groups, or automate posting to specific groups based on activity in another service.. You can also use custom integrations to build group and chat bots that can communicate in groups on Workplace and in Work Chat. ...
Standalone virus-scanner. Context menu integration for Windows Explorer. Add-in for Microsoft Outlook. A portable version that ... "2009-08, Virus.gr 10 August-05 September comparison of effectiveness of antivirus programs". Virus.gr. Archived from the ... In the 1-21 June 2008 test performed by Virus.gr, ClamWin Free Antivirus version 0.93 detected 54.68% of all threats and ranked ... ClamWin Free Antivirus has a virus database which is updated automatically when it detects connection to the Internet. A small ...
Site-specific integration by adeno-associated virus. Proceedings of the National Academy of Sciences, 87(6), 2211-2215. www. ... Romani, M.; Casciano, I.; Querzola, F.; Ambrosis, A. D.; Siniscalco, M. (1993). "Analysis of a viral integration event in a CG- ... Concurrent mapping of an adenovirus 5/SV40 integration site and the U1 snRNA cluster (RNU1) within 400 kb of the chromosome ...
1990). "Site-specific integration by adeno-associated virus". Proc Natl Acad Sci U S A. 87 (6): 2211-5. doi:10.1073/pnas.87.6. ... He is primarily known for his work on adeno-associated viruses (AAV), and his group was one of the first which showed the ... specificity of the integration of the AAV genomes into the cellular genome. He has been a member of the National Academy of ...
Adeno-associated virus integration site 1 is a viral integration site that in humans is encoded by the AAVS1 gene located on ... "Entrez Gene: Adeno-associated virus integration site 1". Ward P, Walsh CE (November 2012). "Targeted integration of a rAAV ... "Characterization of a preferred site on human chromosome 19q for integration of adeno-associated virus DNA by non-homologous ...
Lysogeny involves integration into the host chromosome. "Viral Zone". ExPASy. Retrieved 15 June 2015. ICTV. "Virus Taxonomy: ... Mycoplasmatales virus-laidlawii 2 (L2) (tentative) Mycoplasmatales virus-laidlawii 3 (L3) (tentative) Mycoplasmatales virus- ... The virus exits the host cell by budding. Acholeplasma species serve as the natural host. A productive infectious cycle begins ... This family is poorly studied and little is known about these viruses. The family has one genus, Plasmavirus, which has one ...
He warned however, that such viruses were stable and easily cultured and therefore the emergence of a new virus with a more ... Regulation and Genetics Viral Gene Expression and Integration. Plenum Press. p. 73. ISBN 978-1-4684-0832-4. Manzoni, Tomaz B; ... "Incomplete Forms of Influenza Virus", in Kenneth M. Smith and Max A. Lauffer's Advances in Virus Research, Volume 2, Academic ... "influenza virus system". He called them "incomplete" or "immature". He found that when viruses were expanded at high doses, " ...
Fischer MG, Hackl (December 2016). "Host genome integration and giant virus-induced reactivation of the virophage mavirus". ... The co-infecting viruses are typically giant viruses. Virophages rely on the viral replication factory of the co-infecting ... Unlike satellite viruses, virophages have a parasitic effect on their co-infecting virus. Virophages have been observed to ... Their dependence upon the giant virus for replication often results in the deactivation of the giant viruses. The virophage may ...
Fischer MG, Hackl (December 2016). "Host genome integration and giant virus-induced reactivation of the virophage mavirus". ... Cafeteria roenbergensis is also infected by a second virus, the Mavirus virophage, which is a satellite virus, meaning it is ... This virus interferes with the replication of CroV, which leads to the survival of C. roenbergensis cells. Mavirus is able to ... Marine viruses are a major cause of phytoplankton mortality in the ocean, particularly in warmer, low-latitude waters. Sloppy ...
Fischer MG, Hackl T (December 2016). "Host genome integration and giant virus-induced reactivation of the virophage mavirus". ... Virophages are viruses that replicate only when host cells are co-infected with helper viruses. Following co-infection, helper ... Prophages are genomes of bacteriophages (a type of virus) that are inserted into bacterial chromosomes; prophages can then be ... Miller DW, Miller LK (October 1982). "A virus mutant with an insertion of a copia-like transposable element". Nature. 299 (5883 ...
Fischer MG, Hackl (December 2016). "Host genome integration and giant virus-induced reactivation of the virophage mavirus". ... Mavirus is a genus of double stranded DNA virus that can infect the marine phagotrophic flagellate Cafeteria roenbergensis, but ... Duponchel, S. and Fischer, M.G. (2019) "Viva lavidaviruses! Five features of virophages that parasitize giant DNA viruses". ... Krupovic, M; Kuhn, JH; Fischer, MG (January 2016). "A classification system for virophages and satellite viruses" (PDF). ...
"Entrez Gene: SPI1 spleen focus forming virus (SFFV) proviral integration oncogene spi1". Hallier M, Lerga A, Barnache S, ... "Human T-cell leukemia virus type I Tax transactivates the promoter of human prointerleukin-1beta gene through association with ... Ets and NF-kappaB/NFAT proteins play an important role in their cooperative activation of the human immunodeficiency virus ...
It is considered one of the first computer viruses. Walker also founded the hardware integration manufacturing company ... Stern, Zack (May 2008). "White Paper: The Evolution of Viruses". Maximum PC. Retrieved March 20, 2012. Markoff, John (1999). " ... Parikka, Jussi (2007). Digital Contagions: A Media Archaeology of Computer Viruses. Peter Lang. pp. 41, 239-40. ISBN ...
When two or more viruses, each containing lethal genomic damage, infect the same host cell, the virus genomes can often pair ... Arbuckle JH, Medveczky PG (August 2011). "The molecular biology of human herpesvirus-6 latency and telomere integration". ... Alternatively, if two similar viruses have infected the same host cell, homologous recombination can allow those two viruses to ... Homologous recombination occurs in several groups of viruses. In DNA viruses such as herpesvirus, recombination occurs through ...
"Israeli diagnosed with virus after Italy trip; visitors from there to be barred". The Times of Israel. Retrieved 27 February ... BW, Ministerium für Soziales und Integration (28 February 2020). "In Baden-Württemberg gibt es zwei weitere bestätigte ... "Korona virus: Potvrđeno šest novih slučajeva u Srbiji". BBC News Na Srpskom. 11 March 2020. Retrieved 12 March 2020 - via bbc. ... Giulia Pompili (12 March 2020). "But what help from China against the virus, it's all stuff we purchase". Il Foglio (in Italian ...
"Re-evaluation of the carcinogenic significance of hepatitis B virus integration in hepatocarcinogenesis". PLOS ONE. 7 (9): ... Additionally, the Hepatitis B virus (HBV) and HPV-16 virus, the strain of human papilloma virus most likely to produce cancer, ... "FRA3B extends over a broad region and contains a spontaneous HPV16 integration site: direct evidence for the coincidence of ... "Common fragile sites are preferential targets for HPV16 integrations in cervical tumors". Oncogene. 22 (8): 1225-37. doi: ...
It was the first virus to use a technique known as "code integration". In the words of Ferrie and Ször: This virus supports a ... Simile, a well-known metamorphic virus Computer virus Comparison of computer viruses Aspevik, Egil; Detection of Junk ... Zmist (also known as Z0mbie.Mistfall) is a metamorphic computer virus created by the Russian virus writer known as Z0mbie. ... 6-7 "Hunting for metamorphic", Metamorphic viruses description by Ször and Ferrie "Virus.Win32.ZMist.Predetect" by Secure List ...
Fisher-Adams, G; Wong, KK; Podsakoff, GM; Forman, S; Chatterjee, S (1996). "Integration of adeno-associated virus vector ... "INtegration of Adenoassociated Virus Vectors in CD34+ HUman Hemotopoietic Progenitor Cells After Transduction". Blood. 88 (2): ... Adeno-Associated Virus vectors can be used for stem cell gene therapy. Adenovirus' have a Baltimore classification of level I, ... Her main and current area of research is using Adeno-Associated Virus Vectors (AAV-Vectors). Additionally, she has had a role ...
Wang J, Chenivesse X, Henglein B, Bréchot C (1990). "Hepatitis B virus integration in a cyclin A gene in a hepatocellular ...
Fischer MG, Hackl (December 2016). "Host genome integration and giant virus-induced reactivation of the virophage mavirus" (PDF ... A giant virus, Cafeteria roenbergensis virus (CroV) infects and causes the lysis of C. roenbergensis. The impact of CroV on ... This virus interferes with the replication of CroV, which leads to the survival of C. roenbergensis cells. Mavirus is able to ... Fischer, M. G.; Allen, M. J.; Wilson, W. H.; Suttle, C. A. (2010). "Giant virus with a remarkable complement of genes infects ...
Former Shin Bet Deputy Director Itzhak Ilan died of the virus on 16 October 2020. Actor Yehuda Barkan died of the virus on 23 ... Aliyah and Integration Minister Pnina Tamano-Shata tested positive on 24 August 2020. Knesset member Yinon Azulai tested ... Two contracted the virus at the same toy store: a middle school student who worked at the store, and a school deputy principal ... "Virus cases in New York state double to 22". 5 March 2020. Hilaie, Sivan (26 February 2020). "1,600 Israelis are in 14-day ...
At school, they played together in a band called Revolución, where they covered songs by Sumo, Virus and Miguel Mateos. ... It reflects a musical evolution and a greater integration in the songwriting process. Some of the most outstanding tracks are " ... Colmena Virus Nuevo Calles Desatándonos Perro Inmaduro Punk Me harté Siberiano Viajero Espejismos Nuevo orden Mascota del ... ", "Virus", "Calles" or "Me harté". In 2004, the band releases ESPEJISMOS. That year, keyboard player Ezequiel Araujo decides ...
"Acute hepatitis B virus infection in children and teachers, England and Wales 1985-90". CDR (London, England : Weekly). 1 (17 ... Gentilucci, M.; Cattaneo, L. (2005). "Automatic audiovisual integration in speech perception". Experimental Brain Research. 167 ...
"Vy-PER: eliminating false positive detection of virus integration events in next generation sequencing data". "COPACOBANA : ...
... virus Mosso das Pedras virus Mucambo virus Ndumu virus O'nyong-nyong virus Pixuna virus Rio Negro virus Ross River virus Salmon ... The stable integration of viral genes is mediated by the retroviral interiors of these vectors. There are limitations to the ... Cabassou virus Everglades virus Mosso das Pedras virus Mucambo virus Paramana virus Pixuna virus Rio Negro virus Trocara virus ... encephalitis virus Eilat virus Everglades virus Fort Morgan virus Getah virus Highlands J virus Madariaga virus Mayaro virus ...
The virus, called a prophage in such a state, accomplishes this via integration and excision. The points where the integration ... Araki K, Araki M, Yamamura K (February 1997). "Targeted integration of DNA using mutant lox sites in embryonic stem cells". ... Site-specific recombination is also an important process that viruses, such as bacteriophages, adopt to integrate their genetic ... During site-specific DNA recombination, which brings about genetic rearrangement in processes such as viral integration and ...
Kelly, T J; Rose, J A (1971). "Simian virus 40 integration site in an adenovirus 7-simian virus 40 hybrid DNA molecule". ... Kelly pioneered the study of DNA replication in eukaryotic cells by using DNA viruses as model systems. His laboratory ... where he began to exploit viruses as potentially powerful model systems for exploring the mechanisms of DNA replication in ... "The DNA-activated protein kinase is required for the phosphorylation of replication protein A during simian virus 40 DNA ...
The ClamAV virus database is updated at least every four hours and as of 10 February 2017 contained over 5,760,000 virus ... "The main purpose of this software is the integration with mail servers (attachment scanning). The package provides a flexible ... including viruses. One of its main uses is on mail servers as a server-side email virus scanner. The application was developed ... Most importantly, the virus database is kept up to date."[19] Graphical interfaces[edit]. Since ClamAV does not include a ...
"They should return them." "Elite Prep Schools, Set Back by Virus, Face a Quandary on Federal Aid". nytimes.com. Retrieved May ... In the decades following integration, problems faced by black students lead to the creation of two parent groups outside the ... Sidwell Head of School Search Committee Report "Think Twice, Mnuchin Tells Prep Schools Seeking Virus Loans". nytimes.com. ... Thomas G. (2011). Showdown: JFK and the Integration of the Washington Redskins. Boston, Massachusetts: Beacon Press. p. 6. ISBN ...
Other drug therapy targets include reverse transcriptase, virus attachment, membrane fusion, cDNA integration and virion ... Pettit SC, Everitt LE, Choudhury S, Dunn BM, Kaplan AH (August 2004). "Initial cleavage of the human immunodeficiency virus ... "Active human immunodeficiency virus protease is required for viral infectivity". Proceedings of the National Academy of ... the infectious form of a virus outside of the host cell. Without effective HIV protease, HIV virions remain uninfectious. ...
Avian leukosis virus; others include Rous sarcoma virus Genus Betaretrovirus; type species: Mouse mammary tumour virus Genus ... This gives rise to a concern that insertional mutagenesis due to integration into the host genome might lead to cancer or ... as RNA viruses and classes them separately. "Virus Taxonomy: 2018b Release". International Committee on Taxonomy of Viruses ( ... This virus passes to newborn mice through mammary milk. The mice carrying the virus get mammary cancer because of the ...
... and from viruses and bdellovibrio to blue whales. ... "Toward an integration of landscape and food web ecology: The ...
IBM contributed some of the code it had developed for the integration of the OpenOffice.org suite into Notes 8 to the project.[ ... This class includes server and client backup software, anti-spam and anti-virus products, and e-discovery and archiving systems ... Added blog template, rss feed support, iCal support, SAP integration and "Nomad" which allows you to take your Notes client ... IBM Notes 9 Social Edition removed integration with the office software package IBM Lotus Symphony, which had been integrated ...
"Virus slowing pace of companies' move to Vietnam - Taipei Times". www.taipeitimes.com. 6 May 2020. Retrieved 28 March 2021.. ... one of the most sensitive and persistent problems faced by the government following the beginning of North-South integration in ... most sensitive and persistent problems faced by the revolutionary government following the beginning of North-South integration ...
... is a short term incentive to initiate trial or purchase. Sales promotion is one of the elements of the promotional mix. The primary elements in the promotional mix are advertising, personal selling, direct marketing and publicity/public relations. Sales promotion uses both media and non-media marketing communications for a pre-determined, limited time to increase consumer demand, stimulate market demand or improve product availability. Examples include contests, coupons, freebies, loss leaders, point of purchase displays, premiums, prizes, product samples, and rebates. Sales promotions can be directed at either the customer, sales staff, or distribution channel members (such as retailers). Sales promotions targeted at the consumer are called consumer sales promotions. Sales promotions targeted at retailers and wholesale are called trade sales promotions. Sales promotion includes several communications activities that attempt to provide added value or incentives to consumers, ...
The study used a common cold virus to deliver a normal version of the gene called RPE65 directly into the eyes of affected ... Computers are important tools of integration for the visually impaired person. They allow, using standard or specific programs ... Aside from medical help, various sources provide information, rehabilitation, education, and work and social integration. ... with the lowest risk of suicide and the highest level of social integration. ...
... and human immunodeficiency virus/acquired immunodeficiency syndrome. Am J Trop Med Hyg 2004 ... degree of integration into the global financial system."[11] ...
Integration of hospital/community/primary care via polyclinics.. *Team-work that works is much more evident both in the ... when little was known about the virus, Cuba compulsorily tested thousands of its citizens for HIV. Those who tested positive ... the Cuban Ministry of Public Health officially recognized natural and traditional medicine and began its integration into the ...
There are three main ways the action of the receptor can be classified: relay of signal, amplification, or integration.[2] ... or parts of the outside of a virus or microbe. The endogenously designated -molecule for a particular receptor is referred to ... Relaying sends the signal onward, amplification increases the effect of a single ligand, and integration allows the signal to ...
... simian immunodeficiency virus (SIV) - sinusitis - social integration SIT - SIV - Special Projects of National Significance ( ... herpes simplex virus 1 (HSV-1) - herpes simplex virus 2 (HSV-2) - herpes varicella zoster virus (VZV) - herpes viruses - highly ... human papilloma virus (HPV) - human T cell lymphotropic virus type I (HTLV-I) - human T cell lymphotropic virus type II (HTLV- ... human immunodeficiency virus type 1 (HIV-1) - human immunodeficiency virus type 2 (HIV-2) - human leukocyte antigens (HLA) - ...
F02.4) Dementia in human immunodeficiency virus (HIV) disease. *(F03) Unspecified dementia. *(F04) Organic amnesic syndrome, ...
... "integration disorder"), in an attempt to reduce feelings of shame or embarrassment.[80] The idea that the disease is caused by ... This might relate to increased rates of exposures to viruses before birth.[17] This difference is about 5 to 8 percent.[27] ... a focus on herpes simplex virus.". Herpes 11 (Suppl 2): 83A-88A. PMID 15319094. http://www.stanleylab.org/publications/VIRUSES. ...
Such viruses are either single stranded RNA (e.g. HIV) or double stranded DNA (e.g. Hepatitis B virus) viruses. ... This gives rise to a concern that insertional mutagenesis due to integration into the host genome might lead to cancer or ... Genus Betaretrovirus; type species: Mouse mammary tumour virus. *Genus Gammaretrovirus; type species: Murine leukemia virus; ... "Virus Taxonomy: 2018b Release" (html). International Committee on Taxonomy of Viruses (ICTV). March 2019. Retrieved 16 March ...
Metal-semiconductor-metal (MSM) photodetectors are also used due to their suitability for circuit integration in regenerators ...
Integration is a point of no return for the cell, which becomes a permanent carrier of the viral genome (provirus). Integration ... Early in 2010, scientists solved the crystal structure of IN from prototype foamy virus (PFV) assembled on viral DNA ends. In ... After integration, the viral gene expression and particle production may take place immediately or at some point in the future ... Integration occurs following production of the double-stranded viral DNA by the viral RNA/DNA-dependent DNA polymerase reverse ...
Therefore, the integration of the SIT as the last component of an area-wide integrated approach is essential in many situations ... In 1887, the rinderpest virus was accidentally imported in livestock brought by an Italian expeditionary force to Eritrea. It ... Tsetse fly eradication programmes are complex and logistically demanding activities and usually involve the integration of ...
This helped accelerate the integration of synthesizers into popular music, a shift that had been lent powerful momentum by the ... LFO section of Access Virus C. Main article: Low-frequency oscillation. A low-frequency oscillator (LFO) generates an ...
The role of viruses[edit]. Genes borrowed from viruses have recently been identified as playing a crucial role in the ... Brian Keith Hall; Benedikt Hallgrímsson; Monroe W. Strickberger (2008). Strickberger's evolution: the integration of genes, ... The first is syncytin, which came from a virus. The second identified in 2007 is called EFF1, which helps form the skin of ... Slezak, Michael (2016), "No Viruses? No skin or bones either" (New Scientist, No. 2958, 1 March 2014) p.16 ...
... that gave rise to the v-src oncogene of Rous Sarcoma Virus, a cancer-causing virus first isolated from a chicken sarcoma by ... Brown, P. O.; Bowerman, B.; Varmus, H. E.; Bishop, J. M. (1987-05-08). "Correct integration of retroviral DNA in vitro". Cell. ... Jacks, T. and Varmus, H.E. Expression of the Rous sarcoma virus pol gene by ribosomal frameshifting. Science 230:1237, 1985. ... "Biochemical and genetic evidence for the hepatitis B virus replication strategy". Science. 232: 477-484. doi:10.1126/science. ...
"Diversification of Neoaves: integration of molecular sequence data and fossils" (PDF). Biology Letters. 2 (4): 543-547. PMC ... "Birds, Migration and Emerging Zoonoses: West Nile Virus, Lyme Disease, Influenza A and Enteropathogens". Clinical medicine & ...
... by complexing with the HIV integrase and thereby aborting chromosomal integration of the provirus. HIV infected individuals who ... significantly limiting production of new viruses.[36] ...
"The Wit Virus: A virus built on the ViT ELF virus" (PDF). Retrieved 2008-12-31.. ... "The New Jersey Cybersecurity and Communications Integration Cell (NJCCIC). Retrieved 28 December 2016.. ... Windows Viruses". Retrieved 2008-03-06.. *^ a b c Yeargin, Ray (July 2005). "The short life and hard times of a linux virus". ... Rike - Virus.Linux.Rike.1627[93]. *RST - Virus.Linux.RST.a[94] (known for infecting Korean release of Mozilla Suite 1.7.6 and ...
However, these methods are proving to be ineffective due to the development of resistant strains of the virus or due to the ... and initial integration processes, prevention of zinc finger function can have drastic effects on the function of the cell or ... Other viruses such as SARS, polio, Ebola, measles, human coxsackie, Dengue, rabies, human hepatitis, human parainfluenza and ... By inhibiting the function of NCp7, the viral replication is affected and a non-functional virus that is unable to infect its ...
Many winemakers also feel that better integration of fruit and oak character can be achieved if malolactic fermentation occurs ... Some experimentation with the use of bacteriophages (viruses that infect bacteria) has been conducted to limit malolactic ...
Virus. Death metal[edit]. Though less notable than its black metal scene, Norway is known for death metal. In contrast to black ... Along with other modern country bands, there is an extensive use and integration of folk and rock music. Their song lyrics are ... There is a large integration of folk and country in modern-day country music. As dialects in Norway vary extensively, the music ...
... virus denge (tip 2 oz. DEN-2), herpesvirusi, poliomavirusi (veliki antigen T), papilomavirusi (beljakovina E7) in virus ... "Integration of interferon-alpha/beta signalling to p53 responses in tumour suppression and antiviral defence" (PDF). Nature ... Viri[uredi , uredi kodo]. *Koren, S. (2007). "8. poglavje: Naravna protivirusna odpornost". V: Splošna medicinska virologija ( ... Sen, G.C. (2001). "Viruses and interferons". Annu. Rev. Microbiol. 55: 255-81. PMID 11544356. doi:10.1146/annurev.micro.55.1. ...
The human microbiota includes bacteria, fungi, archaea and viruses. Micro-animals which live on the human body are excluded. ... the holobiont has not only become the principal unit of natural selection but also the result of other step of integration that ... A microbiota includes bacteria, archaea, protists, fungi and viruses. Microbiota have been found to be crucial for immunologic ...
"Apoptosis induced by Oropouche virus infection in HeLa cells is dependent on virus protein expression". Virus Research. 149 (1 ... We mapped by FISH five HPV18 integration sites: three on normal chromosomes 8 at 8q24 and two on derivative chromosomes, der(5) ... These cells have also been used to study viruses such as the oropouche virus (OROV). OROV causes the disruption of cells in ... HeLa cells have been used in testing how parvo virus infects cells of humans, dogs, and cats.[25] ...
"Identification of Arabidopsis thaliana transformants without selection reveals a high occurrence of silenced T-DNA integrations ...
Also called "Integration Day," the purpose is to improve relations between descendants of American slaves and members of the ...
Herpes Simplex Virus Type 1/Adeno-Associated Virus Hybrid Vectors Mediate Site-Specific Integration at the Adeno-Associated ... Site-specific integration by adeno-associated virus. R M Kotin, M Siniscalco, R J Samulski, X D Zhu, L Hunter, C A Laughlin, S ... Site-specific integration by adeno-associated virus. R M Kotin, M Siniscalco, R J Samulski, X D Zhu, L Hunter, C A Laughlin, S ... Site-specific integration by adeno-associated virus. R M Kotin, M Siniscalco, R J Samulski, X D Zhu, L Hunter, C A Laughlin, S ...
... viruses and defragmentation. Yes, folks, its true: sometimes you have to confront those things which you just dont want to ... MGG 392: Viruses, Malware, Defragmenting, Car Integration & More!. Apr 16, 2012 - Download: MP3 Version or AAC Version ... MGG 392: Viruses, Malware, Defragmenting, Car Integration & More!. By John F. Braun ... John and Dave kick off this week with two topics no Mac user ever expects to talk about: viruses and defragmentation. Yes, ...
... but its integration into its native host has not been characterized. In this study, we mapped 477 integration sites of the EIAV ... which is consistent with EIAV and HIV-1 integration in the human genome. Notably, the integration of EIAVFDDV13 favored long ... Published integration sites of EIAV and HIV-1 in the human genome were also analyzed as references. Our results demonstrated ... Equine infectious anemia virus (EIAV) is another well-studied lentivirus that can also be used as a promising retro- ...
Friend leukemia virus integration 1), Authors: Laura M Vecchiarelli-Federico, Mehran Haeri, Yaacov Ben-David. Published in: ... FLI1 (Friend leukemia virus integration 1). Written. 2011-03. Laura M Vecchiarelli-Federico, Mehran Haeri, Yaacov Ben-David. ... Identification of a common viral integration region in Cas-Br-E murine leukemia virus-induced non-T-, non-B-cell lymphomas.. ... Oncogene activation in myeloid leukemias by Graffi murine leukemia virus proviral integration.. ...
Meta- and Orthogonal Integration of Influenza "OMICs" Data Defines a Role for UBR4 in Virus Budding.. Tripathi S1, Pohl MO2, ... Further integration of these data with global virus-host interaction analyses revealed a functionally validated biochemical ... Meta- and Orthogonal Integration of Influenza "OMICs" Data Defines a Role for UBR4 in Virus Budding ... Meta- and Orthogonal Integration of Influenza "OMICs" Data Defines a Role for UBR4 in Virus Budding ...
... recommends testing and linkage to care for persons most likely infected with hepatitis C virus (HCV), including persons with ... human immunodeficiency virus. We explored facilitators and barriers to integrating HCV point-of-care (POC) testing into ... Successful Integration of Hepatitis C Virus Point-of-Care Tests into the Denver Metro Health Clinic,. AIDS Research and ... Successful Integration of Hepatitis C Virus Point-of-Care Tests into the Denver Metro Health Clinic. ...
HBV integration into the host genome has been reported, but its scale, impact and contribution to HCC development is not clear ... Hepatitis B virus (HBV) infection is a leading risk factor for hepatocellular carcinoma (HCC). ... The effects of hepatitis B virus integration into the genomes of hepatocellular carcinoma patients Genome Res. 2012 Apr;22(4): ... Hepatitis B virus (HBV) infection is a leading risk factor for hepatocellular carcinoma (HCC). HBV integration into the host ...
Weitere Produktkategorien zu Friend Leukemia Virus Integration 1 Antikörper * 165 anti-Friend Leukemia Virus Integration 1 ... Am meisten referenzierte anti-Friend Leukemia Virus Integration 1 Antikörper. Show all anti-Friend Leukemia Virus Integration 1 ... Zusätzlich bieten wir Ihnen Friend Leukemia Virus Integration 1 Kits (7) und Friend Leukemia Virus Integration 1 Proteine (7) ... Weitere Antikörper gegen Friend Leukemia Virus Integration 1 Interaktionspartner. Human Friend Leukemia Virus Integration 1 ( ...
Enhanced c-Ki-ras expression associated with Friend virus integration in a bone marrow-derived mouse cell line. D L George, B ... Enhanced c-Ki-ras expression associated with Friend virus integration in a bone marrow-derived mouse cell line ... Enhanced c-Ki-ras expression associated with Friend virus integration in a bone marrow-derived mouse cell line ... Enhanced c-Ki-ras expression associated with Friend virus integration in a bone marrow-derived mouse cell line ...
Recombination of Retrotransposon and Exogenous RNA Virus Results in Nonretroviral cDNA Integration ... Recombination of Retrotransposon and Exogenous RNA Virus Results in Nonretroviral cDNA Integration ... Recombination of Retrotransposon and Exogenous RNA Virus Results in Nonretroviral cDNA Integration ... Recombination of Retrotransposon and Exogenous RNA Virus Results in Nonretroviral cDNA Integration ...
Site-specific integration by adeno-associated virus, p. 213-236. In J. R. Kerr, S. F. Cotmore, M. E. Bloom, R. M. Linden, and C ... Targeted integration of adeno-associated virus (AAV) into human chromosome 19. EMBO J. 10:3941-3950. [PubMed] ... Transcriptional Analysis of the Adeno-Associated Virus Integration Site. Nathalie Dutheil,1 Els Henckaerts,1 Erik Kohlbrenner,2 ... Site-specific integration by adeno-associated virus. Proc. Natl. Acad. Sci. USA 87:2211-2215. [PubMed] ...
Human immunodeficiency virus integration in a cell-free system.. V Ellison, H Abrams, T Roe, J Lifson, P Brown ... Human immunodeficiency virus integration in a cell-free system. Message Subject (Your Name) has forwarded a page to you from ... We have developed an in vitro method for studying the biochemistry of human immunodeficiency virus (HIV) integration by using ... HIV integration did not require a high-energy cofactor, and the enzymatic activities required for integration were recovered ...
A novel real-time nested-PCR assay was developed to quantify integrated human immunodeficiency virus type-1 (HIV-1) DNA with ... Analysis of Human Immunodeficiency Virus Type 1 Integration by Using A Specific, Sensitive and Quantitative Assay Based on Real ... This assay showed that kinetics in viral DNA sysnthesis was cell-type dependent and that the kinetics of HIV-1 DNA integration ... A novel real-time nested-PCR assay was developed to quantify integrated human immunodeficiency virus type-1 (HIV-1) DNA with ...
Gag-Specific CD8+ T Lymphocytes Recognize Infected Cells before AIDS-Virus Integration and Viral Protein Expression. Jonah B. ... Gag-Specific CD8+ T Lymphocytes Recognize Infected Cells before AIDS-Virus Integration and Viral Protein Expression ... Gag-Specific CD8+ T Lymphocytes Recognize Infected Cells before AIDS-Virus Integration and Viral Protein Expression ... Gag-Specific CD8+ T Lymphocytes Recognize Infected Cells before AIDS-Virus Integration and Viral Protein Expression ...
Preferential integration of human immunodeficiency virus type 1 into genes, cytogenetic R bands and GC-rich DNA regions: ... Preferential integration of human immunodeficiency virus type 1 into genes, cytogenetic R bands and GC-rich DNA regions: ...
... resulting from integration into the germline: chromosomally-integrated ... Keywords: chromosomal integration; human herpesvirus; HHV-6; CiHHV-6; HHV-6A; CiHHV-6A; subtelomere; virus genome; telomeric ... Viruses 2016, 8, 19. AMA Style. Tweedy J, Spyrou MA, Pearson M, Lassner D, Kuhl U, Gompels UA. Complete Genome Sequence of ... Viruses. 2016; 8(1):19. Chicago/Turabian Style. Tweedy, Joshua; Spyrou, Maria A.; Pearson, Max; Lassner, Dirk; Kuhl, Uwe; ...
Integration is essential for efficient gene expression of human immunodeficiency virus type 1.. H Sakai, M Kawamura, J Sakuragi ... Integration is essential for efficient gene expression of human immunodeficiency virus type 1. ... Integration is essential for efficient gene expression of human immunodeficiency virus type 1. ... Integration is essential for efficient gene expression of human immunodeficiency virus type 1. ...
However, these sequences facilitate to establish putative virus that provided information underlying virus integration and ... Home » Reconstruction of putative DNA virus from endogenous rice tungro bacilliform virus-like sequences in the rice genome: ... Reconstruction of putative DNA virus from endogenous rice tungro bacilliform virus-like sequences in the rice genome: ... integration manner and involvements of endogenous virus segments in the corresponding disease response. Results: We have ...
Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate ... clonal integrations (,48% of cells), (2) unique integrations (,3% of cells) and (3) subclonal integrations (3%-48% of ... Hepatitis B virus integrations promote local and distant oncogenic driver alterations in hepatocellular carcinoma ... Hepatitis B virus integrations promote local and distant oncogenic driver alterations in hepatocellular carcinoma ...
"Integration of mutations responsible for the attenuated phenotype of Pepper mild mottle virus strains results in a symptomless ... Control of virus by attenuated virus strains. Comparison between attenuated strain of cucumber green mottle mosaic virus and ... Integration of mutations responsible for the attenuated phenotype of Pepper mild mottle virus... Ichiki, T. U.; Nagaoka, E. N ... Integration of mutations responsible for the attenuated phenotype of Pepper mild mottle virus strains results in a symptomless ...
... virus integration sites (integrations within SV or CNV regions were represented in red, integrations near SV or CNV regions ... Integration of Epstein-Barr virus in Burkitts lymphoma cells leads to a region of enhanced chromosome instability. Annals of ... Integration of Epstein-Barr virus into chromosome 6q15 of Burkitt lymphoma cell line (Raji) induces loss of BACH2 expression. ... The effects of hepatitis B virus integration into the genomes of hepatocellular carcinoma patients. Genome research. 2012;22: ...
Journal Article] Integration of Epstein-Barr virus into chromosome 6q15 of Burkitt lymphoma cell line (Raji) induce loss of ... Journal Article] Integration of Epstein-Barr virus into chromosome 6q15 of Burkitt lymphoma cell line (Raji) induce loss of ... Publications] Tetsuya Takakuwa: Integration of Epstein-Barr virus into chromosome 6q15 of Burkitt lymphoma cell line (Raji) ... Epstein-Barr virus / integration / lymphoma / Raji / lymphoblastoid cell line / Rel / Bcl-11A / Bach2. ...
You are here: Home Products by Molecule of Interest WNT-3a (Wingless-type MMTV (mouse mammary tumor virus) integration site ... WNT-3a (Wingless-type MMTV (mouse mammary tumor virus) integration site family member 3a). 0 result found ...
However, these sequences facilitate to establish putative virus that provided information underlying virus integration and ... integration manner and involvements of endogenous virus segments in the corresponding disease response. We have collected ... Recent discoveries of virus-like sequences in plant genomes led us to set the objective of elucidating the origin of the ... Most of them, with the exception of virus-like sequences, do not allow us to trace their origins nor to follow the process of ...
Determination of the cellular-virus DNA junction demonstrated that various lengths of the virus were integrated within 300 bp ... Chimeric hepatitis B virus X gene (HBx)/MLL4 transcripts and the HBx fusion proteins were detected. DNA microarray revealed ... By using an adaptor-ligation/suppression-PCR, we identified four integrations into the myeloid/lymphoid or mixed-lineage ... of MLL4 gene is one of the preferential targets for HBV DNA integration into the MLL4 gene and the HBV DNA integration may be ...
This integration is clearly seen in the geo-epidemiology and phylogeography of HCV. HCV integration can be mirrored either as ... have acted as a vehicle for this integration. Evidence shows that the geographic integration of HCV has been important in the ... CONCLUSION HCV geographic integration is clearly evident and this should be reflected in the prevention and treatment of this ... A critical data assessment and analysis regarding the epidemiological integration of HCV was carried out using the meta- ...
Integration has occurred at a mutational hot spot of the viral genome and appears to be located in a region of semi-repetitive ... Sequence analysis of restriction fragments bearing the virus-host junctions defined 3125 nucleotides of essentially un- ... Integrated hepatitis B virus (HBV) DNA previously cloned from a hepatocellular carcinoma genomic library derived from a ... Integration of hepatitis B virus DNA through a mutational hot spot within the cohesive region in a case of hepatocellular ...
Deep sequencing of the hepatitis B virus in hepatocellular carcinoma patients reveals enriched integration events, structural ... In the tumors, preferential integration of HBV into promoters of genes (P , 0.001) and significant enrichment of integration ... end of hepatitis B virus X protein (HBx), where viral replication/transcription initiates. Upon integration, the 3-end of the ... Deep sequencing of the hepatitis B virus in hepatocellular carcinoma patients reveals enriched integration events, structural ...
The viral DNA site was roughly mapped and the approximate time of integration during the L2 non-cytocidal infectious cycle was ... wt.) genome of mycoplasma virus L2 in lysogenic Acholeplasma laidlawii cells was examined. For this study, DNAs were analysed ... Integration and Lysogeny by an Enveloped Mycoplasma Virus * Kevin Dybvig and Jack Maniloff ... ICTV Virus Taxonomy Profile: Flaviviridae Peter Simmonds, Paul Becher, Jens Bukh, Ernest A. Gould, Gregor Meyers, Tom Monath, ...
Keywords:Adeno-Associated Virus, Gene Therapy, Preferential Integration, PLASMID-BASED, Kilobase. Abstract: Adeno-associated ... Second Generation Adeno-Associated Virus Type 2-based Gene Therapy Systems with the Potential for Preferential Integration into ... Second Generation Adeno-Associated Virus Type 2-based Gene Therapy Systems with the Potential for Preferential Integration into ... Second Generation Adeno-Associated Virus Type 2-based Gene Therapy Systems with the Potential for Preferential Integration into ...
  • Because of AAV's specialized gene therapy advantages, researchers have created an altered version of AAV termed self-complementary adeno-associated virus (scAAV). (wikipedia.org)
  • The detection of over 38000 viruses, worms and trojans is available with this software. (tech-faq.com)
  • It cleans and protects your PC from malware, trojans, adware, worms and viruses too. (spy-emergency.com)
  • Removes unknown trojans, worms, viruses and spyware that traditional detections method do not detect. (spy-emergency.com)
  • Remove Spyware, Trojans, Worms and Viruses for Free with full featured version of Spy Emergency Anti Spyware Software to see it in real action. (spy-emergency.com)
  • VIPRE Antivirus is an all-rounder system security utility which is powerful enough to detect and remove various types of viruses, spyware, rootkits, bots, Trojans, and other types of internet security threats. (download3k.com)
  • Apparently China had good results fighting Corona virus using Chinese herbal medicines. (thenakedscientists.com)
  • Corona virus: Arcada reopens campus in August. (arcada.fi)
  • Matrix Integration works hard to make sure your company emails filter through ransomware, and will keep an eye on threats designed to bypass such filters. (matrixintegration.com)
  • Matrix Integration Internet edge solutions analyze millions of malware samples and terabytes of data per day and push that intelligence to your protection systems which then correlate files, telemetry data, and file behavior against a context-rich knowledge base to proactively defend against known and emerging threats. (matrixintegration.com)
  • Cisco IronPort email and web security products include the industry-leading McAfee anti-virus scanning engine to help businesses manage and protect mission-critical networks from Internet threats. (mcafee.com)
  • With built in malware detection heuristics Spy Emergency Anti Spyware Software detects new and unknown in the wild malware threats even before they are detected by other vendors virus scans and signatures updates. (spy-emergency.com)
  • And this brings us into a risky situation where we may be facing new threats for the single market" which is one of the cornerstones of EU integration, Ribera said. (euractiv.com)
  • Many threats, like viruses and malware, are capable of infiltrating unsecured WiFi networks and spread their infections like wildfire. (techxpress.net)
  • You might be running free anti-spyware to save money but these products may not catch really bad stuff and in the wild malware and spyware including worms, trojan horses or viruses. (spy-emergency.com)
  • Our on-site & field engineers continue to support our customers and our Integration Centers are all fully operational, subject to Government safety guidelines. (computacenter.com)
  • Economic integration has intertwined the health of our populations. (wilsoncenter.org)
  • Understand how the virus is spreading and identify risks to particularly vulnerable populations. (england.nhs.uk)
  • Matrix Integration makes BYOD (Bring Your Own Device) much easier for you to handle. (matrixintegration.com)
  • It's a bonus that Matrix Integration offers a user experience specially designed to protect your company, so that you can rest easy knowing your data is secure in any environment. (matrixintegration.com)
  • Matrix Integration strives to protect such data, and will provide outbound security that keeps such data from being sent to the wrong source. (matrixintegration.com)
  • Matrix Integration separates your private network from the public internet, ensuring your armor is hardened against attack. (matrixintegration.com)
  • Matrix Integration looks beyond the Port 80 and focuses on the content filtering and active blocking that stops the problem before it starts. (matrixintegration.com)
  • Using security intelligence and cognitive threat analytics, Matrix Integration provides proactive protection by sharing up-to-the-second information via live feeds to your next-gen firewall, informing it of suspicious IP addresses and URLs across the world. (matrixintegration.com)
  • Matrix Integration provides solutions that allow you to customize access, log access, and allow entry to individuals based on their roles, from teleworker contractors to vendors and business partners, and restrict their access accordingly. (matrixintegration.com)
  • On demand scanning - Powerful scan engines ensure detection and removal of all viruses at all times. (tech-faq.com)
  • Typical end-point protection capabilities include anti-virus, malware protection, firewall, Instruction Detection and Preventions Systems (IDS/IPS), vulnerability management and device compliance. (wipro.com)
  • Standard virus detection software does not always manage to stop infection by a worm or Trojan. (download3k.com)
  • Campbell was best known for the "Campbell model," which described how some viruses create genetic sleeper agents inside bacteria that wait for a vulnerable moment when they can awaken and kill their hosts. (stanford.edu)
  • Campbell was best known for describing how some viruses create genetic sleeper agents inside bacteria that remain dormant, sometimes for generations, awaiting a vulnerable moment when they can awaken and kill their hosts. (stanford.edu)
  • While at the University of Rochester in New York, Campbell hypothesized that under certain conditions, a particular virus that can attack and kill bacteria did so by inserting its genes into the DNA of its host, the bacteria E. coli. (stanford.edu)
  • The solution protects mission-critical services from malware and viruses, while decreasing operational disruptions. (mcafee.com)
  • The Barracuda Spam and Virus Firewall is a customized dedicated server that contains specialized software for complete protection of your email box. (canadianwebhosting.com)
  • By utilizing dual layer virus blocking, decompression of archives, and file type blocking, the anti-virus engine in the Barracuda Spam Firewall provides complete virus protection. (canadianwebhosting.com)
  • The Barracuda Spam and Virus Firewall is updated hourly with the latest spam and virus definitions. (canadianwebhosting.com)
  • The Barracuda Spam and Virus Firewall can be configured to set spam policies by the end-user on an individualized basis or on a global corporate level. (canadianwebhosting.com)
  • The Barracuda Spam and Virus Firewall can be configured to allow end-users to have control over their individual allow and block lists, which further reduces the chance of false positives. (canadianwebhosting.com)
  • The Barracuda Spam and Virus Firewall is used worldwide by organizations such as Coca Cola, IKEA, YMCA and many other Fortune 500 companies. (canadianwebhosting.com)
  • McAfee's anti-virus scanning engine is integrated with the GWGuardian messaging firewall. (mcafee.com)
  • Advantech , the embedded platform and integration services provider, utilizes McAfee technology for its embedded platforms. (mcafee.com)
  • We should thoroughly evaluate available management platforms and their integration with other security solutions. (wipro.com)
  • The brilliant integration across platforms, digital and traditional advertising didn't. (digobrands.com)
  • The initiative to provide TV for your offices demonstrates that, although Optimum may not have the technical depth of integration for all product features, it is focused on the needs of your business. (top10.com)
  • This means that we are tasked with developing guidance and services that support the integration of immigrants. (arcada.fi)
  • The support for integration in Swedish is important not only for Arcada but for the whole of Finnish society. (arcada.fi)
  • We are at your side with our knowledge and support you in employee integration, for example by means of the shift swap exchange or mobile time recording , for demand-optimized and more flexible personnel deployment, high employee satisfaction and strengthened employer branding. (isgus.de)
  • This is particularly important for medical tourism, safety and efficacy standards for pharmaceuticals and devices, and labor market integration for medical and nursing professionals. (wilsoncenter.org)
  • Fortinet receives high praises from customers for our email security efficacy, integration with the Fortinet Security Fabric, and industry-leading cost to performance. (fortinet.com)
  • Free PC protection against malware, spyware, and viruses. (top10.com)
  • CommuniGate Systems integrates McAfee anti-virus protection with its carrier-class Internet communications software for broadband and mobile service providers, enterprises, universities, and OEM partners. (mcafee.com)
  • MailWatch from Infocrossing , integrates McAfee anti-virus technology as part of its leading virus protection, spam control, and content filtering service, protecting corporate networks worldwide. (mcafee.com)
  • iPolicy integrates McAfee WebShield ASaP technology for anti-virus protection with the ipEnforcer System, which provides multigigabit network-based security and performance. (mcafee.com)
  • Some of us have data plans that count the bytes- and some of us don't have good virus protection. (ni.com)
  • More advanced and recent capabilities include application control, data loss prevention, shared policy integration, memory protection along with an integrated central platform. (wipro.com)
  • Seek out information or badging for credit card transactions, virus protection, or even HIPAA, depending on the services provided. (answernet.com)
  • MuleSoft provides a widely used integration platform for connecting applications, data, and devices in the cloud and on-premises. (mulesoft.com)
  • Anypoint Platform, including CloudHub™ and Mule ESB™ , is built on proven open-source software for fast and reliable on-premises and cloud integration without vendor lock-in. (mulesoft.com)
  • ClamAV team updates Virus Databases on a regular basis and almost immediately after a new virus/variant is out. (tech-faq.com)
  • Updated virus definitions are automatically downloaded according to a schedule of your choice or by a single click on the 'updater' button. (tech-faq.com)
  • Norton Power Eraser is a no-installation, portable virus scanning utility that has more aggressive virus definitions than most competitors. (download3k.com)
  • Polycom and McAfee define the future of security for unified communications, offering the first and only appliance-based conferencing infrastructure solution for the federal government that natively integrates advanced anti-virus scanning. (mcafee.com)
  • Take advantage of built-in security, such as anti-virus integration. (callingallgeeks.org)
  • Cognizant Technology Solutions will acquire TQS Integration, a privately-owned global industrial data and intelligence company based in Lismore, Ireland, for an undisclosed sum. (thehindubusinessline.com)
  • TQS delivers manufacturing data intelligence, global technology consulting and digital systems integration to help manufacturers accelerate digital transformation. (thehindubusinessline.com)
  • Global 360 releases an upgrade of its business process management suite, which includes integration with several Microsoft products. (informationweek.com)
  • The Arrow OEM Computing Solution offers global logistics, integrations, and suppliers that offer best-in-class hardware and software. (mcafee.com)
  • The geopolitical landscape is as fractured as it has been in decades, and with global supply chains being reorganized, the prospects for achieving deeper global integration through trade are fading. (japantimes.co.jp)
  • Between 2017 and 2019, among the surveyed children from selected Central and Eastern European countries, the range of children between nine and 11 years old who experienced virus or spyware on their devices was between four percent in Slovakia and 19 percent in the Czech Republic. (statista.com)
  • is a free anti virus and anti spyware scanner by Dr.Web. (download3k.com)
  • Arcada's Talent Boost service promise (to the Ministry of Education and Culture) 2021-2024 consists of measures for supporting the integration of students and researchers in the Finnish society and the Finnish labour market. (arcada.fi)
  • Automatically scan files using Faronics Anti-Virus before adding them to the whitelist. (faronics.com)
  • Avast is among the most popular anti-virus software in the world at present. (download3k.com)
  • Hummingbird Ltd., a maker of enterprise content management software, has launched integration tools for Microsoft SharePoint. (informationweek.com)
  • Unlike other major economies, China has managed to largely contain the virus. (pressreader.com)
  • Trudeau said the exemption for Americans, despite the rapid rise of cases in the U.S., was due to "the level of integration of our two economies. (denverpost.com)
  • The database will make it easier for researchers to track virus mutations, including strains that pass from human to human. (informationweek.com)
  • Talent Boost is a cross-administrative programme designed to boost the immigration and integration of senior specialists, employees, students and researchers. (arcada.fi)
  • Axway , a leading provider of secure Internet communication solutions, embeds McAfee's anti-virus technology in its messaging applications. (mcafee.com)
  • Also, viruses may be too new to have been widely flagged, or they could be deploying any number of anti-antimalwar-e techniques. (pressreader.com)
  • When he joined Stanford in 1968, Campbell continued his research focus on phage lambda, working to clarify the molecular details of how the virus inserted and removed its genes from the bacterial host. (stanford.edu)
  • The Foundation sponsors international conferences and supports scientists and clinicians seeking to clarify the role of the two HHV-6 viruses in disease. (hhv-6foundation.org)
  • This column shows the number of antivirus services that have flagged that particular process as a potential virus. (pressreader.com)
  • Or, they can snag your personal information and transfer your credit card or bank account information to cyber-thieves.The open source solution is ClamWin , a free anti-virus program. (callingallgeeks.org)
  • Consolidating this information has allowed us to use that data to develop tools and dashboards within a single integrated data platform to give decision-makers more accurate visibility into the status of the response, providing a better understanding of how the virus is spreading, when and where the healthcare system will face strain, and which interventions can best mitigate this. (england.nhs.uk)
  • Suninova® integration solution platform of spatial intelligence & green energy utilization. (suninova.com)
  • Already variants of the virus, identified in the United Kingdom, Brazil, South Africa, and California in the United States, have shown to be more transmissi-ble. (pressreader.com)
  • Clam AntiVirus is a GPL anti-virus toolkit for Unix. (tech-faq.com)
  • Once installed, Comodo AntiVirus wll unobtrusively sit in your system tray, silently and efficiently defending your system from the latest virus outbreaks. (tech-faq.com)
  • Automatic Virus Database Updates are available with this software. (tech-faq.com)
  • if a new user has logged in, even with restricted user rights, the software displays warning messages when new viruses occur. (tech-faq.com)
  • The main purpose of ClamAV is the integration with mail servers (attachment scanning). (tech-faq.com)
  • BitDefender's behavior based search enables it to recognize unknown viruses and mutants. (tech-faq.com)
  • Both countries are eager to choke off the spread of the virus but also maintain their vital economic relationship. (denverpost.com)
  • The excellent media planning and buying only served to spread the fatal message virus. (digobrands.com)
  • An exclusive integration between Addigy and Splashtop gives Apple administrators a new remote access solution for troubleshooting IT problems. (computerworld.com)
  • It is 'interesting' to consider the idea that TCM- which hasn't changed much in centuries, suddenly 'knew' how to deal with a new virus. (thenakedscientists.com)
  • And suddenly there is a virus that divides us, makes us stop all connections. (laitman.com)
  • Unique among pathogens of eukaryotes, retroviruses are distinctive in their replication through an obligate integrated DNA intermediate - the provirus - resulting in many biological consequences unique to this virus group. (nih.gov)
  • Finally, economic integration has been coupled with behavioral and lifestyle convergence, with sometimes unexpected consequences on health. (wilsoncenter.org)
  • The authors note that the chromosomal integration may have important medical consequences for several million people worldwide. (hhv-6foundation.org)
  • This integration will create a powerful application to bring evidence-based, data-driven policy recommendations to the attention of decision-makers in an intuitive and timely manner. (queensu.ca)
  • The HHV-6 Foundation in a non-profit entity founded to encourage scientific exchange between investigators and to provide pilot grants for promising scientific and clinical research on the under- appreciated viruses HHV-6A and HHV-6B. (hhv-6foundation.org)
  • www.nepal24hours.com Integration Through Media under Nepal24hours Inc , is a dedicated online news service delivering and Staffed 24 hours, seven days a week by a dedicated staff at its head office in 11843 Elaine Ave, Artesia, CA 90701, USA, its bureau office in Kathmandu, Nepal and in bureau offices elsewhere brings the latest and up to date news service. (nepal24hours.com)
  • In the world of ubiquitous computing and internet connectedness there is always a real possibility of picking up malware or viruses. (tech-faq.com)
  • And no Canadian in his or her right mind would want to be caught with the virus on the U.S. side of the border, given the predatory U.S. medical pricing system. (denverpost.com)
  • Illustrates knowledge of at least three of the following technologies: Encryption, IDS/IPS, Firewalls, Anti-Virus, VPNs, SSL, Researches emerging technologies to determine impact on application/system integration and execution. (att.jobs)
  • When trojan, worm or computer virus is detected it is automatically blocked. (spy-emergency.com)
  • In modern China, TCM is supported by government to get organised and subject to modern scientific evaluation and integration into western medical practice. (thenakedscientists.com)
  • By speeding up regional integration Asia and Asia-Pacific regions will conquer the challenges in the way, defeating the virus and restoring growth. (globaltimes.cn)