A viral disorder characterized by high FEVER, dry COUGH, shortness of breath (DYSPNEA) or breathing difficulties, and atypical PNEUMONIA. A virus in the genus CORONAVIRUS is the suspected agent.
A species of CORONAVIRUS causing atypical respiratory disease (SEVERE ACUTE RESPIRATORY SYNDROME) in humans. The organism is believed to have first emerged in Guangdong Province, China, in 2002. The natural host is the Chinese horseshoe bat, RHINOLOPHUS sinicus.
A syndrome characterized by outbreaks of late term abortions, high numbers of stillbirths and mummified or weak newborn piglets, and respiratory disease in young unweaned and weaned pigs. It is caused by PORCINE RESPIRATORY AND REPRODUCTIVE SYNDROME VIRUS. (Radostits et al., Veterinary Medicine, 8th ed, p1048)
A class I viral fusion protein that forms the characteristic spikes, or peplomers, found on the viral surface that mediate virus attachment, fusion, and entry into the host cell. During virus maturation, it is cleaved into two subunits: S1, which binds to receptors in the host cell, and S2, which mediates membrane fusion.
A genus of the family CORONAVIRIDAE which causes respiratory or gastrointestinal disease in a variety of vertebrates.
A species of ARTERIVIRUS causing reproductive and respiratory disease in pigs. The European strain is called Lelystad virus. Airborne transmission is common.
Infectious diseases that are novel in their outbreak ranges (geographic and host) or transmission mode.
Viral proteins found in either the NUCLEOCAPSID or the viral core (VIRAL CORE PROTEINS).
The family of civets which are small and medium-sized Old World carnivores, often striped or spotted.
A species in the genus CORONAVIRUS causing the common cold and possibly nervous system infections in humans. It lacks hemagglutinin-esterase.
Virus diseases caused by the CORONAVIRUS genus. Some specifics include transmissible enteritis of turkeys (ENTERITIS, TRANSMISSIBLE, OF TURKEYS); FELINE INFECTIOUS PERITONITIS; and transmissible gastroenteritis of swine (GASTROENTERITIS, TRANSMISSIBLE, OF SWINE).
Restriction of freedom of movement of individuals who have been exposed to infectious or communicable disease in order to prevent its spread; a period of detention of vessels, vehicles, or travelers coming from infected or suspected places; and detention or isolation on account of suspected contagion. It includes government regulations on the detention of animals at frontiers or ports of entrance for the prevention of infectious disease, through a period of isolation before being allowed to enter a country. (From Dorland, 28th ed & Black's Veterinary Dictionary, 17th ed)
Sudden increase in the incidence of a disease. The concept includes EPIDEMICS and PANDEMICS.
The former British crown colony located off the southeast coast of China, comprised of Hong Kong Island, Kowloon Peninsula, and New Territories. The three sites were ceded to the British by the Chinese respectively in 1841, 1860, and 1898. Hong Kong reverted to China in July 1997. The name represents the Cantonese pronunciation of the Chinese xianggang, fragrant port, from xiang, perfume and gang, port or harbor, with reference to its currents sweetened by fresh water from a river west of it.
A CELL LINE derived from the kidney of the African green (vervet) monkey, (CERCOPITHECUS AETHIOPS) used primarily in virus replication studies and plaque assays.
Layers of protein which surround the capsid in animal viruses with tubular nucleocapsids. The envelope consists of an inner layer of lipids and virus specified proteins also called membrane or matrix proteins. The outer layer consists of one or more types of morphological subunits called peplomers which project from the viral envelope; this layer always consists of glycoproteins.
The transmission of infectious disease or pathogens from patients to health professionals or health care workers. It includes transmission via direct or indirect exposure to bacterial, fungal, parasitic, or viral agents.
A characteristic symptom complex.
A species of CERCOPITHECUS containing three subspecies: C. tantalus, C. pygerythrus, and C. sabeus. They are found in the forests and savannah of Africa. The African green monkey (C. pygerythrus) is the natural host of SIMIAN IMMUNODEFICIENCY VIRUS and is used in AIDS research.
Immunoglobulins produced in response to VIRAL ANTIGENS.
The segregation of patients with communicable or other diseases for a specified time. Isolation may be strict, in which movement and social contacts are limited; modified, where an effort to control specified aspects of care is made in order to prevent cross infection; or reverse, where the patient is secluded in a controlled or germ-free environment in order to protect him or her from cross infection.
Suspensions of attenuated or killed viruses administered for the prevention or treatment of infectious viral disease.
Glycoproteins found on the membrane or surface of cells.
Programs of disease surveillance, generally within health care facilities, designed to investigate, prevent, and control the spread of infections and their causative microorganisms.
A species in the genus CORONAVIRUS causing the common cold and possibly nervous system infections in humans. It contains hemagglutinin-esterase.
Proteins found in any species of virus.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
A peptidyl-dipeptidase that catalyzes the release of a C-terminal dipeptide, -Xaa-*-Xbb-Xcc, when neither Xaa nor Xbb is Pro. It is a Cl(-)-dependent, zinc glycoprotein that is generally membrane-bound and active at neutral pH. It may also have endopeptidase activity on some substrates. (From Enzyme Nomenclature, 1992) EC 3.4.15.1.
The process of intracellular viral multiplication, consisting of the synthesis of PROTEINS; NUCLEIC ACIDS; and sometimes LIPIDS, and their assembly into a new infectious particle.
Identification of those persons (or animals) who have had such an association with an infected person, animal, or contaminated environment as to have had the opportunity to acquire the infection. Contact tracing is a generally accepted method for the control of sexually transmitted diseases.
Proteins encoded by a VIRAL GENOME that are produced in the organisms they infect, but not packaged into the VIRUS PARTICLES. Some of these proteins may play roles within the infected cell during VIRUS REPLICATION or act in regulation of virus replication or VIRUS ASSEMBLY.
Specific molecular components of the cell capable of recognizing and interacting with a virus, and which, after binding it, are capable of generating some signal that initiates the chain of events leading to the biological response.
A protein-nucleic acid complex which forms part or all of a virion. It consists of a CAPSID plus enclosed nucleic acid. Depending on the virus, the nucleocapsid may correspond to a naked core or be surrounded by a membranous envelope.
The measurement of infection-blocking titer of ANTISERA by testing a series of dilutions for a given virus-antiserum interaction end-point, which is generally the dilution at which tissue cultures inoculated with the serum-virus mixtures demonstrate cytopathology (CPE) or the dilution at which 50% of test animals injected with serum-virus mixtures show infectivity (ID50) or die (LD50).
A mutant strain of TRANSMISSIBLE GASTROENTERITIS VIRUS causing mild or subclinical respiratory infections in young SWINE. It may also play a role in post-weaning porcine respiratory disease complex, especially when combined with other respiratory agents.
An enzyme that catalyses RNA-template-directed extension of the 3'- end of an RNA strand by one nucleotide at a time, and can initiate a chain de novo. (Enzyme Nomenclature, 1992, p293)
The entering of cells by viruses following VIRUS ATTACHMENT. This is achieved by ENDOCYTOSIS, by direct MEMBRANE FUSION of the viral membrane with the CELL MEMBRANE, or by translocation of the whole virus across the cell membrane.
Established cell cultures that have the potential to propagate indefinitely.
Ribonucleic acid that makes up the genetic material of viruses.
A country spanning from central Asia to the Pacific Ocean.
A general term for diseases produced by viruses.
Any of various animals that constitute the family Suidae and comprise stout-bodied, short-legged omnivorous mammals with thick skin, usually covered with coarse bristles, a rather long mobile snout, and small tail. Included are the genera Babyrousa, Phacochoerus (wart hogs), and Sus, the latter containing the domestic pig (see SUS SCROFA).
Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.
Order of mammals whose members are adapted for flight. It includes bats, flying foxes, and fruit bats.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
Proteins associated with the inner surface of the lipid bilayer of the viral envelope. These proteins have been implicated in control of viral transcription and may possibly serve as the "glue" that binds the nucleocapsid to the appropriate membrane site during viral budding from the host cell.
The temporal sequence of events that have occurred.
A species of the CORONAVIRUS genus causing hepatitis in mice. Four strains have been identified as MHV 1, MHV 2, MHV 3, and MHV 4 (also known as MHV-JHM, which is neurotropic and causes disseminated encephalomyelitis with demyelination as well as focal liver necrosis).
A genus of the family ARTERIVIRIDAE, in the order NIDOVIRALES. The type species is ARTERITIS VIRUS, EQUINE.
The individuals employed by the hospital.
Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly.
Proteins which are synthesized as a single polymer and then cleaved into several distinct proteins.
ENDOPEPTIDASES which have a cysteine involved in the catalytic process. This group of enzymes is inactivated by CYSTEINE PROTEINASE INHIBITORS such as CYSTATINS and SULFHYDRYL REAGENTS.
Diseases of non-human animals that may be transmitted to HUMANS or may be transmitted from humans to non-human animals.
The complete genetic complement contained in a DNA or RNA molecule in a virus.
Substances elaborated by viruses that have antigenic activity.
A species in the genus CORONAVIRUS causing upper and lower RESPIRATORY TRACT INFECTIONS. It shares the receptor used by the SARS VIRUS.
The lone species in the genus Nyctereutes, family CANIDAE. It is found in the woodland zone from southeastern Siberia to Vietnam and on the main islands of Japan.
The level of protein structure in which combinations of secondary protein structures (alpha helices, beta sheets, loop regions, and motifs) pack together to form folded shapes called domains. Disulfide bridges between cysteines in two different parts of the polypeptide chain along with other interactions between the chains play a role in the formation and stabilization of tertiary structure. Small proteins usually consist of only one domain but larger proteins may contain a number of domains connected by segments of polypeptide chain which lack regular secondary structure.
A family of viruses, of the order NIDOVIRALES, containing spherical virions. In contrast to CORONAVIRIDAE, no protruding spikes are obvious on the surface.
A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.
Aspects of health and disease related to travel.
Methods used for studying the interactions of antibodies with specific regions of protein antigens. Important applications of epitope mapping are found within the area of immunochemistry.
Programs of surveillance designed to prevent the transmission of disease by any means from person to person or from animal to man.
The transmission of infectious disease or pathogens. When transmission is within the same species, the mode can be horizontal or vertical (INFECTIOUS DISEASE TRANSMISSION, VERTICAL).
A serotonin antagonist with limited antihistaminic, anticholinergic, and immunosuppressive activity.
A sequence of successive nucleotide triplets that are read as CODONS specifying AMINO ACIDS and begin with an INITIATOR CODON and end with a stop codon (CODON, TERMINATOR).
An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.
Any infection which a patient contracts in a health-care institution.
A province of Canada lying between the provinces of Manitoba and Quebec. Its capital is Toronto. It takes its name from Lake Ontario which is said to represent the Iroquois oniatariio, beautiful lake. (From Webster's New Geographical Dictionary, 1988, p892 & Room, Brewer's Dictionary of Names, 1992, p391)
Devices that cover the nose and mouth to maintain aseptic conditions or to administer inhaled anesthetics or other gases. (UMDNS, 1999)
Antibodies that reduce or abolish some biological activity of a soluble antigen or infectious agent, usually a virus.
Supplying a building or house, their rooms and corridors, with fresh air. The controlling of the environment thus may be in public or domestic sites and in medical or non-medical locales. (From Dorland, 28th ed)
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
Invasion of the host RESPIRATORY SYSTEM by microorganisms, usually leading to pathological processes or diseases.
Diseases of the first cranial (olfactory) nerve, which usually feature anosmia or other alterations in the sense of smell and taste. Anosmia may be associated with NEOPLASMS; CENTRAL NERVOUS SYSTEM INFECTIONS; CRANIOCEREBRAL TRAUMA; inherited conditions; toxins; METABOLIC DISEASES; tobacco abuse; and other conditions. (Adams et al., Principles of Neurology, 6th ed, pp229-31)
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
Inflammation of the lung parenchyma that is caused by a viral infection.
Enzymes that act at a free C-terminus of a polypeptide to liberate a single amino acid residue.
INFLAMMATION of the PANCREAS. Pancreatitis is classified as acute unless there are computed tomographic or endoscopic retrograde cholangiopancreatographic findings of CHRONIC PANCREATITIS (International Symposium on Acute Pancreatitis, Atlanta, 1992). The two most common forms of acute pancreatitis are ALCOHOLIC PANCREATITIS and gallstone pancreatitis.
The binding of virus particles to receptors on the host cell surface. For enveloped viruses, the virion ligand is usually a surface glycoprotein as is the cellular receptor. For non-enveloped viruses, the virus CAPSID serves as the ligand.
The period of recovery following an illness.
Viral proteins that are components of the mature assembled VIRUS PARTICLES. They may include nucleocapsid core proteins (gag proteins), enzymes packaged within the virus particle (pol proteins), and membrane components (env proteins). These do not include the proteins encoded in the VIRAL GENOME that are produced in infected cells but which are not packaged in the mature virus particle,i.e. the so called non-structural proteins (VIRAL NONSTRUCTURAL PROTEINS).
The relationships of groups of organisms as reflected by their genetic makeup.
Semi-synthetic complex derived from nucleic-acid free viral particles. They are essentially reconstituted viral coats, where the infectious nucleocapsid is replaced by a compound of choice. Virosomes retain their fusogenic activity and thus deliver the incorporated compound (antigens, drugs, genes) inside the target cell. They can be used for vaccines (VACCINES, VIROSOME), drug delivery, or gene transfer.
Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures.
Elements of limited time intervals, contributing to particular results or situations.
The sudden sensation of being cold. It may be accompanied by SHIVERING.
Infections caused by viruses of the genus ARTERIVIRUS.
Physicians or other qualified individuals responsible for implementing and overseeing the policies and procedures followed by a health care facility to reduce the risk of infection to patients and staff.
Animate or inanimate sources which normally harbor disease-causing organisms and thus serve as potential sources of disease outbreaks. Reservoirs are distinguished from vectors (DISEASE VECTORS) and carriers, which are agents of disease transmission rather than continuing sources of potential disease outbreaks.
The concept pertaining to the health status of inhabitants of the world.
Clothing designed to protect the individual against possible exposure to known hazards.
The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B.
Visible morphologic changes in cells infected with viruses. It includes shutdown of cellular RNA and protein synthesis, cell fusion, release of lysosomal enzymes, changes in cell membrane permeability, diffuse changes in intracellular structures, presence of viral inclusion bodies, and chromosomal aberrations. It excludes malignant transformation, which is CELL TRANSFORMATION, VIRAL. Viral cytopathogenic effects provide a valuable method for identifying and classifying the infecting viruses.
Disease having a short and relatively severe course.
The activities and endeavors of the public health services in a community on any level.
Diseases of domestic swine and of the wild boar of the genus Sus.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
Proteins prepared by recombinant DNA technology.
An interferon regulatory factor that is expressed constitutively and undergoes POST-TRANSLATIONAL MODIFICATION following viral infection. PHOSPHORYLATION of IRF-3 causes the protein to be translocated from the CYTOPLASM to CELL NUCLEUS where it binds DNA, and activates transcription.
Interferon secreted by leukocytes, fibroblasts, or lymphoblasts in response to viruses or interferon inducers other than mitogens, antigens, or allo-antigens. They include alpha- and beta-interferons (INTERFERON-ALPHA and INTERFERON-BETA).
X-ray visualization of the chest and organs of the thoracic cavity. It is not restricted to visualization of the lungs.
Cell lines developed from disaggregated BALB/c mouse embryos. They are extremely sensitive to CONTACT INHIBITION, and highly susceptible to transformation by SV40 VIRUS and murine sarcoma virus (SARCOMA VIRUSES, MURINE).
The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.
Events, characteristics, or other definable entities that have the potential to bring about a change in a health condition or other defined outcome.
Men and women working in the provision of health services, whether as individual practitioners or employees of health institutions and programs, whether or not professionally trained, and whether or not subject to public regulation. (From A Discursive Dictionary of Health Care, 1976)
The capacity of a normal organism to remain unaffected by microorganisms and their toxins. It results from the presence of naturally occurring ANTI-INFECTIVE AGENTS, constitutional factors such as BODY TEMPERATURE and immediate acting immune cells such as NATURAL KILLER CELLS.
The interactions between a host and a pathogen, usually resulting in disease.
A PREDNISOLONE derivative with similar anti-inflammatory action.
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
A severe form of acute INFLAMMATION of the PANCREAS characterized by one or more areas of NECROSIS in the pancreas with varying degree of involvement of the surrounding tissues or organ systems. Massive pancreatic necrosis may lead to DIABETES MELLITUS, and malabsorption.
A proteolytic enzyme obtained from Carica papaya. It is also the name used for a purified mixture of papain and CHYMOPAPAIN that is used as a topical enzymatic debriding agent. EC 3.4.22.2.
Vaccines in which the infectious microbial nucleic acid components have been destroyed by chemical or physical treatment (e.g., formalin, beta-propiolactone, gamma radiation) without affecting the antigenicity or immunogenicity of the viral coat or bacterial outer membrane proteins.
A subclass of PEPTIDE HYDROLASES that catalyze the internal cleavage of PEPTIDES or PROTEINS.
A weight-carrying structure for navigation of the air that is supported either by its own buoyancy or by the dynamic action of the air against its surfaces. (Webster, 1973)
Diagnostic procedures involving immunoglobulin reactions.
An abnormal elevation of body temperature, usually as a result of a pathologic process.
Deoxyribonucleic acid that makes up the genetic material of viruses.
In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
Short sequences (generally about 10 base pairs) of DNA that are complementary to sequences of messenger RNA and allow reverse transcriptases to start copying the adjacent sequences of mRNA. Primers are used extensively in genetic and molecular biology techniques.
The study of crystal structure using X-RAY DIFFRACTION techniques. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
The largest country in North America, comprising 10 provinces and three territories. Its capital is Ottawa.
A syndrome characterized by progressive life-threatening RESPIRATORY INSUFFICIENCY in the absence of known LUNG DISEASES, usually following a systemic insult such as surgery or major TRAUMA.
The arrangement of two or more amino acid or base sequences from an organism or organisms in such a way as to align areas of the sequences sharing common properties. The degree of relatedness or homology between the sequences is predicted computationally or statistically based on weights assigned to the elements aligned between the sequences. This in turn can serve as a potential indicator of the genetic relatedness between the organisms.
The degree of similarity between sequences of amino acids. This information is useful for the analyzing genetic relatedness of proteins and species.
A nucleoside antimetabolite antiviral agent that blocks nucleic acid synthesis and is used against both RNA and DNA viruses.
A chromosome disorder associated either with an extra chromosome 21 or an effective trisomy for chromosome 21. Clinical manifestations include hypotonia, short stature, brachycephaly, upslanting palpebral fissures, epicanthus, Brushfield spots on the iris, protruding tongue, small ears, short, broad hands, fifth finger clinodactyly, Simian crease, and moderate to severe INTELLECTUAL DISABILITY. Cardiac and gastrointestinal malformations, a marked increase in the incidence of LEUKEMIA, and the early onset of ALZHEIMER DISEASE are also associated with this condition. Pathologic features include the development of NEUROFIBRILLARY TANGLES in neurons and the deposition of AMYLOID BETA-PROTEIN, similar to the pathology of ALZHEIMER DISEASE. (Menkes, Textbook of Child Neurology, 5th ed, p213)
The quantity of measurable virus in a body fluid. Change in viral load, measured in plasma, is sometimes used as a SURROGATE MARKER in disease progression.
Any of the processes by which cytoplasmic factors influence the differential control of gene action in viruses.
A species of CORONAVIRUS causing a fatal disease to pigs under 3 weeks old.
McGeer led the investigations into Severe Acute Respiratory Syndrome (SARS) in Toronto. She was based at the Ontario SARS ... McGeer studies the prevention and management of bacterial and viral infections. Her primary areas of research interest are the ... The basic reproduction number of severe acute respiratory syndrome-related coronavirus (SARS-CoV) was between 2.2 and 3.7, but ... McGeer has led investigations into the severe acute respiratory syndrome outbreak in Toronto and worked alongside Donald Low. ...
... which play a crucial role in the early stages of viral infections, such as severe acute respiratory syndrome (SARS). ... "Expression profile of immune response genes in patients with Severe Acute Respiratory Syndrome". BMC Immunol. 6: 2. doi:10.1186 ... lactoferrin prevents viral infection". Antiviral Res. 53 (2): 153-8. doi:10.1016/S0166-3542(01)00197-8. PMID 11750941. Carvalho ... Lactoferrin levels in tear fluid have been shown to decrease in dry eye diseases such as Sjögren's syndrome. A rapid, portable ...
... specifically in Severe acute respiratory syndrome coronavirus (SARS-CoV). PTB has been proposed as a potential treatment for ... COVID-19 and related Viral Infections. Babic I, Nurmemmedov E, Yenugonda VM, Juarez T, Nomura N, Pingle SC, Glassy MC, Kesari S ...
... he played a key role in establishing bioinformatics workflows for genomic analysis of Severe acute respiratory syndrome ... On completing his thesis, Loman developed an interest in emerging viral infections, using Nanopore sequencing to track the ... He undertook an intercalated BSc degree in Pathology (Infection & Immunity) from Imperial College in 2001 and graduated in ... Loman has been professor of microbial genomics and bioinformatics at the Institute for Microbiology and Infection at the ...
Klein became interested in the differences between how men and women responded to Severe Acute Respiratory Syndrome CoronaVirus ... that this biological sex dependent disparity in outcomes is common to many viral infections that impact the respiratory tract. ... This allows rodents to maintain hantaviridae infections. Her research may help us better predict how hantaviridae they can be ... Klein, S.L. (2000). "The effects of hormones on sex differences in infection: from genes to behavior". Neuroscience & ...
... the severe acute respiratory syndrome (SARS) Coronavirus outbreak, the Middle Eastern Respiratory Syndrome (MERS) Coronavirus ... epidemiology of animal-human influenza and other human respiratory viral infections, authoring over 320 research publications. ... Lau YL, Peiris JS (2005). "Pathogenesis of severe acute respiratory syndrome". Curr. Opin. Immunol. 17 (4): 404-10. doi:10.1016 ... 2003). "Coronavirus as a possible cause of severe acute respiratory syndrome". Lancet. 361 (9366): 1319-25. doi:10.1016/S0140- ...
... disease Poliomyelitis Q-fever Prion diseases Rabies Relapsing fever Rubella Salmonellosis Severe acute respiratory syndrome ( ... Viral infections in central nervous system West Nile fever Yellow fever Yersiniosis Group B diseases are reported to the ... Infection or carrier state of Streptococcus pneumoniae with reduced susceptibility to penicillin Infection or carrier state of ... diarrhoea associated Hepatitis A Hepatitis B Hepatitis C HPV-infection causing cancer or pre-cancerous lesions Infection or ...
... the viral infection resulting from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can cause a rare type of ... Berkowitz, A. L.; Westover, M. B.; Bianchi, M. T.; Chou, S. H.- Y. (2014-07-23). "Aspirin for acute stroke of unknown etiology ... Berkowitz, A. L.; Westover, M. B.; Bianchi, M. T.; Chou, S. H.- Y. (2014-07-23). "Aspirin for acute stroke of unknown etiology ... The overreaction of the immune system in response to SARS-CoV-2 infection triggers a cytokine storm, whereby immune cells and ...
... and Middle East respiratory syndrome-related coronavirus (MERS-CoV). Severe acute respiratory syndrome coronavirus 2 is another ... they rarely become ill from viral infections, and rabies is the only viral illness known to kill bats. Much research has been ... SARS-CoV causes the disease severe acute respiratory syndrome (SARS) in humans. The first documented case of SARS was in ... Several zoonotic coronaviruses are associated with bats, including severe acute respiratory syndrome coronavirus (SARS-CoV) ...
In 2003 Fish led investigations antivirals that could into the severe acute respiratory syndrome (SARS) outbreak in Toronto. ... IFN-α is a naturally occurring protein that is produced in response to viral infection, and has been shown to have therapeutic ... "Interferon alfacon-1 plus corticosteroids in severe acute respiratory syndrome: a preliminary study". JAMA. 290 (24): 3222-3228 ... After this study, the IFN-α developed by Fish was used to treat patients with Middle East Respiratory Syndrome (MERS). Fish ...
As SARS is a viral disease, antibiotics do not have direct effect but may be used against bacterial secondary infection. ... Severe acute respiratory syndrome (SARS) is a viral respiratory disease of zoonotic origin caused by severe acute respiratory ... In December 2019, another strain of SARS-CoV was identified as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). ... the first identified strain of the SARS coronavirus species severe acute respiratory syndrome-related coronavirus (SARSr-CoV). ...
... which play a crucial role in the early stages of viral infections, such as severe acute respiratory syndrome (SARS).[53] ... "Expression profile of immune response genes in patients with Severe Acute Respiratory Syndrome". BMC Immunology. 6: 2. doi: ... lactoferrin prevents viral infection". Antiviral Research. 53 (2): 153-8. doi:10.1016/S0166-3542(01)00197-8. PMID 11750941.. ... "American Journal of Respiratory and Critical Care Medicine. 175 (2): 174-83. doi:10.1164/rccm.200607-1029OC. PMC 2720149. PMID ...
In 2002, a highly pathogenic SARS-CoV (Severe Acute Respiratory Syndrome Coronavirus) strain emerged from a zoonotic reservoir ... Their immune systems have evolved in such a way as to suppress any inflammatory response to viral infections, thereby allowing ... including severe acute respiratory syndrome-related coronaviruses and Ebola/Marburg hemorrhagic fever filoviruses. In terms of ... "Middle East respiratory syndrome coronavirus (MERS-CoV)". WHO. Retrieved 15 April 2020. Sharif-Yakan A, Kanj SS (December 2014 ...
March 2005). "Severe acute respiratory syndrome coronavirus 3a protein is a viral structural protein". J. Virol. 79 (5): 3182-6 ... Maintaining an appropriate balance in the amounts of each of these structural proteins produced during viral infection appears ... "Severe acute respiratory syndrome coronavirus 7a accessory protein is a viral structural protein". J. Virol. 80 (15): 7287-94. ... A viral structural protein is a viral protein that is a structural component of the mature virus. Examples include the SARS ...
... also interfere with the immune system response to the viral infection by cleaving three immune system proteins. PLpro cleaves ... which caused the 2002-2004 outbreak of severe acute respiratory syndrome (SARS), and severe acute respiratory syndrome ... to Severe acute respiratory syndrome-related coronavirus at Wikimedia Commons Data related to Severe acute respiratory syndrome ... Two strains of the virus have caused outbreaks of severe respiratory diseases in humans: severe acute respiratory syndrome ...
On severe acute respiratory syndrome, or Sars, he said in 2003 "What Sars has done is rekindle the concept of the global ... He also has interests in chronic viral infections of the liver. He is a consultant virologist to the National Blood Service and ... 1995 onwards Head of Blood Borne Virus Unit at the Centre for Infections, Health Protection Agency, Colindale Standing Advisory ... and Council Member Society for General Microbiology European Association for the Study of the Liver European Rapid Viral ...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can also result in pneumonia. Fungal pneumonia is uncommon, but ... Viral infections, can be confirmed via detection of either the virus or its antigens with culture or polymerase chain reaction ... ISBN 978-81-8448-749-7. Lai CC, Shih TP, Ko WC, Tang HJ, Hsueh PR (March 2020). "Severe acute respiratory syndrome coronavirus ... For adults with moderate or severe acute respiratory distress syndrome (ARDS) undergoing mechanical ventilation, there is a ...
... severe acute respiratory syndrome virus Erythrovirus: Parvovirus B19 Filoviruses: Ebola virus and Marburg virus Flaviviruses: ... Viral hepatitis is liver inflammation due to a viral infection. It may present in acute form as a recent infection with ... It is now classified as GB virus C. Hepatitis C virus (HCV) are causing acute and chronic infections that is a major cause of ... "Acute Viral Hepatitis : Introduction Harrison's Principle of Internal Medicine, 17 Edition". Ringehan, Marc; McKeating, Jane A ...
The first known infections from SARS‑CoV‑2 were discovered in Wuhan, China. The original source of viral transmission to humans ... ICTV announced "severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)" as the name of the new virus on 11 February 2020 ... Severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) is the virus that causes COVID-19 (coronavirus disease 2019), the ... Taxonomically, SARS‑CoV‑2 is a virus of the species severe acute respiratory syndrome-related coronavirus (SARSr-CoV). It is ...
The goal is to genetically express the spike glycoprotein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). A ... Adenovirus has been used for delivery of CRISPR/Cas9 gene editing systems, but high immune reactivity to viral infection has ... Most infections with adenovirus result in infections of the upper respiratory tract. Adenovirus infections often present as ... Type 1 infection can also cause respiratory and eye infections. CAdV-1 also affects foxes (Vulpes vulpes and Vulpes lagopus) ...
Chinese scientists first discovered the severe acute respiratory syndrome (SARS) coronavirus in February 2003, but due to ... Once it was apparent the viral infections could selectively alter behavior and steady state brain levels of neurotransmitter ... "Identification of a severe acute respiratory syndrome coronavirus-like virus in a leaf-nosed bat in Nigeria". mBio. 1 (4). doi: ... Middle East respiratory syndrome (MERS) was first reported in Saudi Arabia during June 2012 when a local man was initially ...
"Clinical management of severe acute respiratory infection when novel coronavirus (nCoV) infection is suspected". World Health ... "Treatment for severe acute respiratory distress syndrome from COVID-19". The Lancet Respiratory Medicine. doi:10.1016/S2213- ... Moriyama, M; Hugentobler, WJ; Iwasaki, A (20 March 2020). "Seasonality of Respiratory Viral Infections". Annual Review of ... "Clinical management of severe acute respiratory infection when novel coronavirus (2019-nCoV) infection is suspected" (PDF). ...
Middle East respiratory syndrome coronavirus (MERS-CoV) Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Aspiration ... Acute bronchitis can be defined as acute bacterial or viral infection of the larger airways in healthy patients with no history ... A virus Influenza B virus Human parainfluenza viruses Human respiratory syncytial virus Severe acute respiratory syndrome ... Antibiotics do not help the many lower respiratory infections which are caused by parasites or viruses. While acute bronchitis ...
April 2021). "Dismantling myths on the airborne transmission of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)". ... La Rosa G, Fratini M, Della Libera S, Iaconelli M, Muscillo M (1 June 2013). "Viral infections acquired indoors through ... Airborne infections usually occur by the respiratory route, with the agent present in aerosols (infectious particles < 5 µm in ... An ideal humidity for preventing aerosol respiratory viral transmission at room temperature appears to be between 40% and 60% ...
... www.medpagetoday.com/InfectiousDisease/URItheFlu/tb/2450 Fujian flu Severe acute respiratory syndrome "Epidemiology of WHO- ... "The prevention and treatment of viral respiratory disorders". Retrieved September 2007. Check date values in: ,access-date= ( ... Human flu symptoms usually include fever, cough, sore throat, muscle aches, conjunctivitis and, in severe cases, severe ... So far, H5N1 infections in humans are attributed to bird-to-human transmission of the virus in most cases. Until May 2006, the ...
SARS-CoV Mpro and severe acute respiratory syndrome coronavirus main protease. The protease 3CLpro is a potential drug target ... for coronavirus infections due to its essential role in processing the polyproteins that are translated from the viral RNA. The ... and substrate specificity of severe acute respiratory syndrome coronavirus 3C-like proteinase". The Journal of Biological ... Possible Urgent Prevention and Treatment Options for Severe Acute Respiratory Infections Caused by 2019-nCoV". ChemBioChem. 21 ...
... severe acute respiratory syndrome (SARS) and measles. Chest radiographs (X-ray photographs) often show a pulmonary infection ... and is contrasted with viral pneumonia. Known viral causes of atypical pneumonia include respiratory syncytial virus (RSV), ... "Severe Acute Respiratory Syndrome (SARS) - multi-country outbreak". Archived from the original on 7 December 2008. Retrieved ... "Primary atypical pneumonia" at Dorland's Medical Dictionary Commission on Acute Respiratory Diseases, Fort Bragg, North ...
... and renamed it Severe acute respiratory syndrome-related coronavirus in 2009. By mid-July 2003, the infection subsided, and by ... A viral infection in pigs, called transmissible gastroenteritis, which was characterised mainly by diarrhoea and vomiting, and ... Zoonotic species such as Severe acute respiratory syndrome-related coronavirus (SARS-CoV), Middle East respiratory syndrome- ... "ICTV Taxonomy history: Severe acute respiratory syndrome-related coronavirus". International Committee on Taxonomy of Viruses ( ...
COVID-19 is caused by infection with a virus called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). SARS-CoV-2 ... The first known infections from SARS‑CoV‑2 were discovered in Wuhan, China. The original source of viral transmission to humans ... SARS-CoV-2 is a virus of the species severe acute respiratory syndrome-related coronavirus (SARSr-CoV). It is believed to have ... COVID-19 Severe acute respiratory syndrome coronavirus 2 World Health Organization's response to the COVID-19 pandemic "The ...
... severe acute respiratory syndrome coronavirus 2 Protozoan: Trypanosoma cruzi (causing Chagas disease) and Toxoplasma gondii ... If one tests positive for an acute viral infection, clinical developments have discovered that 1% to 5% of said population may ... Viral myocarditis being an outcome of viral infection depends heavily on genetic host factors and the pathogenicity unique to ... Myocarditis is most often due to a viral infection. Other causes include bacterial infections, certain medications, toxins, and ...
Acute respiratory distress syndrome (ARDS), alveolar hemorrhage, and allergic reactions (usually expressed in first 30 minutes ... "A systematic review of viral infections associated with oral involvement in cancer patients: a spotlight on Herpesviridea". ... For this same group, severe cardiovascular events were observed with a rate of about 1 in 1500. The most common severe adverse ... and hepatic VOD has lately been referred to as sinusoidal obstruction syndrome (SOS). Severe cases of SOS are associated with a ...
Severe fever with thrombocytopenia syndrome. *Tete orthobunyavirus. *Tick-borne encephalitis. Protozoan infections. *Babesiosis ... Kirsch M, Ruben FL, Steere AC, Duray PH, Norden CW, Winkelstein A (May 1988). "Fatal adult respiratory distress syndrome in a ... such as diverticulitis and acute coronary syndrome.[36][106] Diagnosis of late-stage Lyme disease is often complicated by a ... Unlike viral meningitis, Lyme lymphocytic meningitis tends to not cause fever, last longer, and recur.[33][30] Lymphocytic ...
Garenne M; Ronsmans C, Campbell H (1992). "The magnitude of mortality from acute respiratory infections in children under 5 ... pulmonya ay maaaring magdulot ng hindi paggana ng paghinga sa pamamagitan ng pagdudulot ng acute respiratory distress syndrome ... Figueiredo LT (2009). "Viral pneumonia: epidemiological, clinical, pathophysiological and therapeutic aspects". J Bras Pneumol ... Rello, J (2008). "Demographics, guidelines, and clinical experience in severe community-acquired pneumonia". Critical care ( ...
Respiratory system/. acute viral nasopharyngitis/. viral pneumonia. DNA virus. *Epstein-Barr virus *EBV infection/Infectious ... ultimately causing severe cerebellar atrophy.[14] This syndrome, called JCV granule cell layer neuronopathy (JCV GCN), is ... Infection and pathogenesis[edit]. The initial site of infection may be the tonsils,[4] or possibly the gastrointestinal tract.[ ... Other strains and novel pathological syndromes[edit]. Although JC virus infection is classically associated with white matter ...
Miscellaneous - ECMO, kidney or bone marrow transplant, hemodialysis, kidney failure, severe burn, celiac disease, severe acute ... They defend against bacterial or fungal infection. They are usually first responders to microbial infection; their activity and ... Infectious diseases - viral (AIDS, SARS, West Nile encephalitis, hepatitis, herpes, measles, others), bacterial (TB, typhoid, ... They are rare in the blood, but numerous in the mucous membranes of the respiratory, digestive, and lower urinary tracts.[9] ...
People with COPD can experience flare-ups that are often triggered by a viral or bacterial respiratory infection.[100] The ... they decrease acute exacerbations in those with either moderate or severe disease.[143] By themselves, they have no effect on ... George L. Waldbott, an American allergist, first described a new disease he named "smoker's respiratory syndrome" in the 1953 ... acute. Acute bronchitis. chronic. COPD Chronic bronchitis. Acute exacerbation of COPD). Asthma (Status asthmaticus. Aspirin- ...
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) bats, pangolins, felines, minks respiratory transmission 2019 ... Unidentified infection of the pigs amplified the force of infection, eventually transmitting the virus to farmers and causing ... "Haemorrhagic fevers, Viral". World Health Organization. Archived from the original on 27 July 2019. Retrieved 19 June 2019.. ... Severe acute respiratory syndrome SARS coronavirus bats, civets close contact, respiratory droplets ...
Severe radiologic signs (pneumoperitoneum). *Additional laboratory changes (metabolic and respiratory acidosis, disseminated ... Vertically transmitted infection. *Neonatal infection *Congenital rubella syndrome. *Neonatal herpes simplex. *Mycoplasma ... A Cochrane review in 2014 found that supplementation of probiotics enterally "prevents severe NEC as well as all-cause ... Some children may suffer from short bowel syndrome if extensive portions of the bowel had to be removed. ...
... respiratory tract infections, and a weak cough. Respiratory failure is the most common cause of death in ALS.[5] ... Examples include flail arm syndrome, flail leg syndrome, and isolated bulbar ALS. Flail arm syndrome and flail leg syndrome are ... In August 2014, a challenge went viral online, commonly known as the "ALS Ice Bucket Challenge".[131] Contestants fill a bucket ... A 2015 review found that moderate to severe traumatic brain injury is a risk factor for ALS, but whether mild traumatic brain ...
Hypopnea syndrome, abnormally shallow breathing or slow respiratory rate while sleeping.. *Idiopathic hypersomnia, a primary, ... Not a disorder unless severe. Often seen as part of narcolepsy.. *Sleepwalking or somnambulism, engaging in activities normally ... In one particular study, participants (18 years or older) who had experienced acute or chronic sleep disorders were put in a ... disruption of sleep cycle due to infection). Other disorders include sleepwalking, night terrors and bed wetting. Management of ...
The most common viral infection of the mouth is gingivostomatitis caused by herpes simplex. A common fungal infection is ... The pharynx is a part of the conducting zone of the respiratory system and also a part of the digestive system. It is the part ... Irritable bowel syndrome (IBS) is the most common of the functional gastrointestinal disorders. These are idiopathic disorders ... This can cause mesenteric ischemia if severe enough. A common disorder of the bowel is diverticulitis. Diverticula are small ...
Bacterial infection is the most common cause.[8] Often many different types of bacteria are involved in a single infection.[6] ... Pseudomonal pyoderma / Pseudomonas hot-foot syndrome / Hot tub folliculitis / Ecthyma gangrenosum / Green nail syndrome ... Antibiotics in addition to standard incision and drainage is recommended in persons with severe abscesses, many sites of ... abscess may be performed by positioning the patient in a way that enables the contents to be discharged via the respiratory ...
Thomas, Roger E; Jefferson, Tom; Lasserson, Toby J (2 June 2016). Cochrane Acute Respiratory Infections Group (ed.). "Influenza ... This difference in the site of infection may be part of the reason why the H5N1 strain causes severe viral pneumonia in the ... associated with human conjunctivitis and a fatal case of acute respiratory distress syndrome". Proceedings of the National ... "Interleukin-1 is responsible for acute lung immunopathology but increases survival of respiratory influenza virus infection". ...
However, respiratory failure is the most common cause of death in people with Leigh syndrome. Other neurological symptoms ... Different genetic causes and types of Leigh syndrome have different prognoses, though all are poor. The most severe forms of ... such as an infection or surgery. The general course of Leigh syndrome is one of episodic developmental regression during times ... French Canadian Leigh syndrome[edit]. The type of Leigh syndrome found at a much higher rate in the Saguenay-Lac-Saint-Jean ...
Viral conjunctivitis is often associated with an infection of the upper respiratory tract, a common cold, or a sore throat. Its ... The most common causes of acute bacterial conjunctivitis are Staphylococcus aureus, Streptococcus pneumoniae, and Haemophilus ... Severe crusting of the infected eye and the surrounding skin may also occur. The gritty or scratchy feeling is sometimes ... Ocular ischemic syndrome / Central retinal vein occlusion. *Central retinal artery occlusion. *Branch retinal artery occlusion ...
... such as the advent of a concurrent acute viral infection), which sends the body reeling through a new cascade of events. Such ... Respiratory compensation a mechanism of the respiratory center, adjusts the partial pressure of carbon dioxide by changing the ... This hormone enhances the tachycardia and causes severe vasoconstriction of the arterioles to all but the essential organ in ... "Altitude Illness - Cerebral Syndromes". eMedicine Specialties , Emergency Medicine , Environmental.. *^ Alberts, Bruce (2002 ...
... s are implicated in the emergence of severe acute respiratory syndrome (SARS) in China, since they serve as natural hosts ... Brüssow, H. (2012). "On Viruses, Bats and Men: A Natural History of Food-Borne Viral Infections". Viruses: Essential Agents of ... "Experimental infection of bats with Geomyces destructans causes white-nose syndrome". Nature. 480 (7377): 376-378. Bibcode: ... White nose syndrome is a condition associated with the deaths of millions of bats in the Eastern United States and Canada.[164] ...
"Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection in Children and Adolescents: A Systematic Review". JAMA ... the immune system and vitamin D supplements have previously been shown to lower the risk of viral respiratory tract infections ... "Clinical management of severe acute respiratory infection when novel coronavirus (2019-nCoV) infection is suspected" (PDF). 26 ... "Severe acute respiratory syndrome coronavirus 2 data hub". NCBI. 21 Mart 2020 tarihinde kaynağından arşivlendi. Erişim tarihi: ...
... said it did not expect a vaccine against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the causative virus, to ... The Chinese company CanSino Biologics is making a viral vector vaccine. This vaccine uses an adenovirus that has the spike ... 8 billion from forty countries to support rapid development of vaccines to prevent COVID-19 infections and deaths.[9] The ... "Inhibition of SARS-CoV-2 infections in engineered human tissues using clinical-grade soluble human ACE2" (PDF). Cell. doi ...
... often causing acute respiratory distress syndrome, which kills in half of all cases. Preliminary research suggests that ... This suggests that the virus is unlikely to cause severe infections similar to those caused by the 1918 pandemic flu virus or ... No circulating flu has yet shown any resistance to zanamivir (Relenza), the other available anti-viral. Swine Before being ... This may explain why some patients experience severe respiratory symptoms. (The H5N1 virus is also able to infect cells deep in ...
Middle East Respiratory Syndrome) a SARS (Severe Acute Respiratory Syndrome). Jeho sekvencia RNA obsahuje približne 30 000 báz ... Viral dynamics of SARS-CoV-2 across a spectrum of disease severity in COVID-19. The Journal of Infection, 2020-04-18. PMID: ... Severe Acute Respiratory Syndrome Coronavirus 2, predtým dočasne ako 2019-nCoV), ktorý patrí do rodu Betacoronavirus a bol po ... Dexamethasone reduces death in hospitalised patients with severe respiratory complications of COVID-19 , University of Oxford [ ...
"Clinical management of severe acute respiratory infection when novel coronavirus (nCoV) infection is suspected". www.who.int ( ... "Severe acute respiratory syndrome-related coronavirus - The species and its viruses, a statement of the Coronavirus Study Group ... Viral pneumonia, sindrom kesusahan pernafasan akut, kegagalan buah pinggang. Punca. SARS-CoV-2. ... "Microbes and Infection (dalam bahasa Inggeris). doi:10.1016/j.micinf.2020.01.003. ISSN 1286-4579. PMID 32017984.. ...
Gene therapy typically involves the use of a non-infectious virus (i.e., a viral vector such as the adeno-associated virus) to ... This is now discouraged since it can bring on dangerous side effects such as neuroleptic malignant syndrome.[74] Most people ... Parkinson's disease can cause neuropsychiatric disturbances, which can range from mild to severe. This includes disorders of ... but drugs and infection are not the only factors, and underlying brain pathology or changes in neurotransmitters or their ...
Respiratory complications tend to develop on about the eighth day of the illness and can be either viral or bacterial in origin ... Because the person was infected with Variola virus, a severe infection could result, and the person could transmit smallpox to ... The clinical definition of smallpox is an illness with acute onset of fever equal to or greater than 38.3 °C (101 °F) followed ... The Neurological Manifestations of Pediatric Infectious Diseases and Immunodeficiency Syndromes. Springer Science & Business ...
The cause of Reye syndrome is unknown.[2] It usually begins shortly after recovery from a viral infection, such as influenza or ... case of H5N1 avian influenza infection in a human with complications of adult respiratory distress syndrome and Reye's syndrome ... In children, mild to severe permanent brain damage is possible, especially in infants. Over thirty percent of the cases ... Redirected from Reye's syndrome). Jump to navigation Jump to search Syndrome characterized by acute brain damage and liver ...
"A systematic review of viral infections associated with oral involvement in cancer patients: a spotlight on Herpesviridea". ... Tumor lysis syndrome[edit]. In particularly large tumors and cancers with high white cell counts, such as lymphomas, teratomas ... In very severe myelosuppression, which occurs in some regimens, almost all the bone marrow stem cells (cells that produce white ... Two girls with acute lymphoblastic leukemia receiving chemotherapy. The girl at left has a central venous catheter inserted in ...
Respiratory system/. acute viral nasopharyngitis/. viral pneumonia. DNA virus. *Epstein-Barr virus *EBV infection/Infectious ... Severe acute respiratory syndrome. *V: Orthomyxoviridae: Influenzavirus A/B/C/D *Influenza/Avian influenza ... Untreated, median survival is only 2.5 months, sometimes due to concurrent opportunistic infections rather than the lymphoma ... infection (, 90%) in immunodeficient patients (such as those with AIDS and those immunosuppressed),[2] and does not have a ...
Reactivation of an existing (dormant) viral infection has been suggested as a cause of acute Bell's palsy.[16] This new ... The cause of Bell's palsy is unknown.[1] Risk factors include diabetes, a recent upper respiratory tract infection, and ... In severe disease it is also unclear. One 2015 review found no effect regardless of severity.[32] Another review found a small ... of existing herpes zoster infection leading to facial paralysis in a Bell's palsy type pattern is known as Ramsay Hunt syndrome ...
Acute liver failure. Respiratory failure. Multiple organ dysfunction syndrome. *Neonatal infection. *Polytrauma ... Bacterial infections are the most common cause, but fungal, viral, and protozoan infections can also lead to sepsis.[3] Common ... Severe sepsis. Septic shock. Multiple organ dysfunction syndrome. Other shock. Cardiogenic shock. Distributive shock. ... Lungs: acute respiratory distress syndrome (ARDS) (PaO2/FiO2 ratio, 300), different ratio in pediatric acute respiratory ...
Translational control during viral infection, investigating the role of severe acute respiratory syndrome non-structural ... Translational control during viral infection, investigating the role of severe acute respiratory syndrome non-structural ... This thesis focused on translational control during viral infection, where we investigated the role of Severe Acute Respiratory ... Syndrome non-structural protein 1 and Enterovirus 71 Internal Ribosome Entry Site in this process. To establish the function of ...
After implementation of provincewide public health measures that included strict infection-control practices, the number of ... Severe acute respiratory syndrome (SARS) was first recognized in Toronto in a woman who returned from Hong Kong on February 23 ... Viral-infections; Respiratory-infections; Respiratory-system-disorders; Pulmonary-system-disorders ... Severe acute respiratory syndrome (SARS) was first recognized in Toronto in a woman who returned from Hong Kong on February 23 ...
1 A novel coronavirus has been identified as the aetiological agent of the syndrome.2 3 Viral infection may produce various ... Severe acute respiratory syndrome (SARS) is an emerging infection that is spreading worldwide ... Identification of severe acute respiratory syndrome in Canada. N Engl J Med 2003; 348: 1995-2005. ... A major outbreak of severe acute respiratory syndrome in Hong Kong. N Engl J Med 2003; 348: 1986-94. ...
... including for treatment of Middle East respiratory syndrome coronavirus CoV infection. ... or hyperimmune immunoglobulin may be of clinical benefit for treatment of severe acute respiratory infections (SARIs) of viral ... of convalescent plasma and hyperimmune immunoglobulin for the treatment of severe acute respiratory infections of viral ... Keywords: MERS coronavirus; convalescent plasma; meta-analysis; severe acute respiratory infection; systematic review. ...
We review the melatonergic pathway role in viral infections, emphasizing … ... severe acute respiratory syndrome coronavirus 2 ... We review the melatonergic pathway role in viral infections, ... Melatonin: Roles in influenza, Covid-19, and other viral infections Rev Med Virol. 2020 May;30(3):e2109. doi: 10.1002/rmv.2109 ... Focussing on immune regulators has treatment implications for covid-19 and other viral infections. ...
ALI, air-liquid interface; SARS-CoV-2, Severe Acute Respiratory Syndrome Coronavirus 2; t-SNE, t-distributed stochastic ... scientists are still learning about essential viral biological features of its causative pathogen, the novel severe acute ... reduce disease in animal models of both SARS-CoV-2 and the closely related betacoronavirus severe acute respiratory syndrome ... respiratory syndrome coronavirus 2 (SARS-CoV-2).. New research, published in PLOS Biology, has evaluated SARS-CoV-2 infection ...
SARS is caused by a type of coronavirus, which can cause mild to moderate upper respiratory illness, such as the common cold. ... is a respiratory illness that first infected people in parts of Asia, North America, and Europe in late 2002 and early 2003. ... Eun-Hyung Lee F, Treanor JJ (2010). Viral infections. In R Mason et al., eds., Murray and Nadels Textbook of Respiratory ... Severe Acute Respiratory Syndrome (SARS). Topic Overview. What is SARS?. Severe acute respiratory syndrome (SARS) is a ...
... is a respiratory disease caused by the coronavirus SARS-CoV. Symptoms include fever and shortness of breath. Read about ... Severe Acute Respiratory Syndrome (SARS). *Severe acute respiratory syndrome (SARS) facts. *What is severe acute respiratory ... Causes of diarrhea include viral, bacterial, or parasite infection, gastroenteritis, food poisoning, and drugs. Absorbents and ... "Severe Acute Respiratory Syndrome (SARS)." ,www.who.int/csr/sars/,.. Trivedi, Manish N. "Severe Acute Respiratory Syndrome ( ...
Viral infections; Humans; SARS; Severe Acute Respiratory Syndrome; Dose response; Survival rate; Oxygen levels; Neutrophils; ... all of whom met criteria for severe COVID-19 as well as moderate-to-severe acute respiratory distress syndrome. Patients ... Likewise, acute phase reactants declined, with mean C-reactive protein, ferritin, and D-dimer reduction of 77% (P < 0.001), 43 ... Exosomes derived from bone marrow mesenchymal stem cells as treatment for severe COVID-19. ...
Its genome is closest to that of severe acute respiratory syndrome-related coronaviruses from horseshoe bats, and its receptor- ... We showed that severe acute respiratory syndrome coronavirus 2 is probably a novel recombinant virus. ... Viral metagenomics revealed sendai virus and coronavirus infection of Malayan pangolins (Manis javanica). Viruses. 2019;11:. ... Lau SK, Woo PC, Li KS, Huang Y, Tsoi HW, Wong BH, et al. Severe acute respiratory syndrome coronavirus-like virus in Chinese ...
Severe acute respiratory syndrome coronavirus infection of human ciliated airway epithelia: role of ciliated cells in viral ... such as the severe acute respiratory syndrome (SARS)-CoV and the Middle East respiratory syndrome-CoV, cause acute respiratory ... Middle East respiratory syndrome. PI. perivascular inflammation. p.i.. postinfection. SARS. severe acute respiratory syndrome. ... Pathogenic coronaviruses (CoVs), such as severe acute respiratory syndrome (SARS)-CoV and Middle East respiratory syndrome ( ...
Weiss SR, Navas-Martin S (2005) Coronavirus pathogenesis and the emerging pathogen severe acute respiratory syndrome ... Characterization of a novel coronavirus associated with severe acute respiratory syndrome. Science 300(5624):1394-1399PubMed ... Zhao RY, Elder RT (2005) Viral infections and cell cycle G2/M regulation. Cell Res 15(3):143-149PubMedGoogle Scholar ... Bagga S., Bouchard M.J. (2014) Cell Cycle Regulation During Viral Infection. In: Noguchi E., Gadaleta M. (eds) Cell Cycle ...
Interestingly, there was no evidence of viral infection, including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 ... "It is possible that the virus was cleared by the time of death or that viral copy numbers were below the level of detection by ... In summary, vascular pathology was found in 10 cases, perivascular infiltrates were present in 13 cases, acute ischemic hypoxic ...
2004) In vitro inhibition of severe acute respiratory syndrome coronavirus by chloroquine Biochem. Biophys. Res. Commun. 323, ... So, your claim that because chloroquine is primarily an anti-malarial it cant be used to treat a viral infection like SARS-CoV ... as an effective inhibitor of the replication of the severe acute respiratory syndrome coronavirus (SARS-CoV) in vitro. ... https://www.researchgate.net/publication/8361588_In_vitro_inhibition_of_severe_acute_respiratory_syndrome_coronavirus_by_ ...
Severe acute respiratory syndrome coronavirus envelope protein regulates cell stress response and apoptosis PLoS Pathogens ... Virus infection rapidly activates the P58(IPK) pathway, delaying peak kinase activation to enhance viral replication Virology ... Severe acute respiratory syndrome virus (SARS-CoV) that lacks the envelope (E) gene (rSARS-CoV-ΔE) is... ... contributes to viral protein synthesis by decreasing the activity of the anti-viral protein, PKR. Here, we constructed a ...
... percentage of people who contract the deadly pandemic COVID-19 coronavirus develop severe lung symptoms that may include viral ... Symptoms of viral pneumonia include low-grade fever, coughing up mucus, tiredness, and muscle aches. A ... Pneumonia is an infection or inflammation of the lungs. It can be in just one part of the lungs, or it can involve many parts. ... Severe acute respiratory syndrome (SARS), which is also caused by a virus in the coronavirus family, had a major outbreak in ...
"Severe acute respiratory syndrome" (SARS) is a viral upper respiratory infection associated with a newly described coronavirus ... d. Severe Acute Respiratory Syndrome (SARS) Virus. In November 2002 an atypical pneumonia of unknown etiology emerged in Asia ... of infections resulting from S. aureus were identified as MRSA infections, and 25.2% of enterococcal infections were attributed ... post mortem from a neonate diagnosed with fulminant septicemia, meningitis, and respiratory distress syndrome.1038 Because ...
Evidence is emerging that viral deubiquitinating enzymes can play a role in virus infection. Adenovirus infection is ... Genome Replication and Regulation of Viral Gene Expression. The Papain-Like Protease from the Severe Acute Respiratory Syndrome ... The severe acute respiratory syndrome coronavirus papain-like protease (SARS-CoV PLpro) is involved in the processing of the ... Severe acute respiratory syndrome (SARS): a year in review. Annu. Rev. Med. 56:357-381. ...
Enzyme-Linked Immunosorbent Assay Using Chemiluminescence for Detection of Severe Acute Respiratory Syndrome Viral Infection ... Detection of Severe Acute Respiratory Syndrome Coronavirus RNA in Plasma during the Course of Infection Wei-Kung Wang, Chi-Tai ... Epidemiological and Genetic Correlates of Severe Acute Respiratory Syndrome Coronavirus Infection in the Hospital with the ... Rapid and Sensitive Detection of Severe Acute Respiratory Syndrome Coronavirus by Rolling Circle Amplification Bin Wang, Simon ...
... against severe acute respiratory syndrome (SARS). This systematic review and meta-analysis supports the use of respiratory ... but not viral infections or ILI. Meta-analysis of observational studies provided evidence of a protective effect of masks (OR ... A mask keeps others safe from your respiratory droplets. The mask is not a personal shield that protects a person from getting ...
Viral Shedding Patterns of Coronavirus in Patients with Probable Severe Acute Respiratory Syndrome Lancet (London, England). ... We studied viral shedding of SARS coronavirus to improve diagnosis and infection control. Reverse-transcriptase PCR was done on ... Severe acute respiratory syndrome (SARS) is thought to be caused by a novel coronavirus, SARS-associated coronavirus. ... Factors such as genetics of histocompatibility, dysregulation of T-cells, B-cells and viral infections have been implicated. ...
Severe Acute Respiratory Syndrome. Coronavirus Infections. Pneumonia, Viral. Pneumonia. Respiratory Distress Syndrome, Adult. ... Severe Acute Respiratory Syndrome Respiratory Distress Syndrome, Infant Acute Respiratory Distress Syndrome ... COVID-19 SARS-CoV Infection SARS (Severe Acute Respiratory Syndrome) SARS Pneumonia ARDS, Human Pneumonia, Viral Dietary ... Respiratory Tract Infections. Coronaviridae Infections. Nidovirales Infections. RNA Virus Infections. Virus Diseases. ...
This review summarizes the state-of-the-art of current antiviral options against influenza infection, with particular focus on ... will ideally enter the clinics and reinforce the therapeutic arsenal to combat influenza virus infections. ... will ideally enter the clinics and reinforce the therapeutic arsenal to combat influenza virus infections. ... This review summarizes the state-of-the-art of current antiviral options against influenza infection, with particular focus on ...
SARS - Severe Acute Respiratory Syndrome. What is SARS? Travellers going to areas where SARS is potentially endemic should be ... Rabies is an acute viral infection, which affects the central nervous system. Symptoms .... Read More ... What is Hepatitis A? This disease is a viral infection, which can be silent. The incubation period is 15-50 days followed by no ... Typhoid is a Bacterial Infection Typhoid is an infection caused by bacteria. The bacteria is similar to the one that causes ...
Severe Acute Respiratory Syndrome. Virus Diseases. Coronaviridae Infections. Nidovirales Infections. RNA Virus Infections. ... While most respiratory viruses are more infectious when a patient is symptomatic, viral, epidemiology and modeling evidence ... Clinical indicators of severe clinical course: Admission to intensive care unit (ICU), Acute Respiratory Distress Syndrome ( ... Furukawa NW, Brooks JT, Sobel J. Evidence Supporting Transmission of Severe Acute Respiratory Syndrome Coronavirus 2 While ...
Coronaviruses and Acute Respiratory Syndromes (COVID-19, MERS, and SARS) - Learn about the causes, symptoms, diagnosis & ... Symptoms of SARS resemble those of other more common respiratory viral infections but are more severe. They include fever, ... Severe Acute Respiratory Syndrome (SARS) Severe acute respiratory syndrome is a coronavirus infection that causes flu-like ... Middle East Respiratory Syndrome (MERS) Middle East respiratory syndrome is a coronavirus infection that causes severe flu-like ...
... cells and their role during a SARS-CoV-2 infection. ... Upon SARS-CoV-2 infection, what are the changes occurring on ... Respiratory, SARS, SARS-CoV-2, Severe Acute Respiratory, Severe Acute Respiratory Syndrome, Stress, Syndrome, T-Cell, Tumor, ... other viral proteins may be the principal mediators of ADCC during infection." ... The coronavirus disease 2019 (COVID-19) pandemic is caused by the novel beta coronavirus, severe acute respiratory syndrome ...
  • What happens in the first few days of SARS-CoV-2 infection? (news-medical.net)
  • As the coronavirus disease (COVID-19) pandemic continues to spread globally, scientists are still learning about essential viral biological features of its causative pathogen, the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). (news-medical.net)
  • New research, published in PLOS Biology , has evaluated SARS-CoV-2 infection in primary cultures of well-differentiated cells to determine how the virus affects the body and how the infection starts. (news-medical.net)
  • In animal studies, researchers determined the accumulation and distribution of SARS-CoV-2 in the respiratory system. (news-medical.net)
  • U.S.-based researchers - at Loyola University Chicago and the University of Iowa - extended this research but focused on the high-resolution images of the first stages of SARS-CoV-2 infection and the innate immune responses that followed. (news-medical.net)
  • These cells contain regenerative capacity, which can be affected by SARS-CoV-2 infection. (news-medical.net)
  • In that case, it can help reduce disease in animal models of both SARS-CoV-2 and the closely related betacoronavirus severe acute respiratory syndrome coronavirus (SARS-CoV). (news-medical.net)
  • RESEARCH LETTERS the low prevalence of SARS-CoV-2 infection. (cdc.gov)
  • The previously unknown coronavirus that causes this syndrome was first identified in Asia in early 2003, hence its name, 'SARS-associated coronavirus' or SARS-CoV. (medicinenet.com)
  • As of October 2012, SARS-CoV has been added to the National Select Agent Registry, which regulates the handling and possession of bacteria, viruses , or toxins that have potential to pose a severe threat to public health and safety. (medicinenet.com)
  • During April 2020, ExoFlo was provided to 24 SARS-CoV-2 polymerase chain reaction-positive patients at a single hospital center, all of whom met criteria for severe COVID-19 as well as moderate-to-severe acute respiratory distress syndrome. (cdc.gov)
  • The causative agent was rapidly isolated from patients and identified to be a coronavirus, now designated as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by the International Committee on Taxonomy of Viruses ( 1 ). (cdc.gov)
  • Whereas SARS-CoV and Middle East respiratory syndrome coronavirus were rapidly traced to their immediate animal sources (civet and dromedaries, respectively), the origin of SARS-CoV remains obscure. (cdc.gov)
  • Pathogenic human coronaviruses (CoVs), such as the severe acute respiratory syndrome (SARS)-CoV and the Middle East respiratory syndrome-CoV, cause acute respiratory illness. (jimmunol.org)
  • To investigate these differences, we infected male and female mice of different age groups with SARS-CoV and analyzed their susceptibility to the infection. (jimmunol.org)
  • Our results showed that male mice were more susceptible to SARS-CoV infection compared with age-matched females. (jimmunol.org)
  • The degree of sex bias to SARS-CoV infection increased with advancing age, such that middle-aged mice showed much more pronounced differences compared with young mice. (jimmunol.org)
  • Pathogenic coronaviruses (CoVs), such as severe acute respiratory syndrome (SARS)-CoV and Middle East respiratory syndrome (MERS)-CoV and newly identified SARS- and MERS-like CoVs pose a significant threat to public health ( 1 - 7 ). (jimmunol.org)
  • SARS-CoV and MERS-CoV infect airway and alveolar epithelial cells and cause acute respiratory illnesses ( 8 , 9 ). (jimmunol.org)
  • In addition to age-dependent disease susceptibility, epidemiological studies showed sex-specific differences in the incidence and case fatality rates (CFRs) in humans after SARS-CoV infection, with males experiencing higher CFRs compared with females ( 20 , 21 ). (jimmunol.org)
  • Interestingly, there was no evidence of viral infection, including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). (medscape.com)
  • PLoS Pathogens Dediego ML, Nieto-Torres JL, Jiménez-Guardeño JM, Regla-Nava JA, Alvarez E, Oliveros JC, Zhao J, Fett C, Perlman S, Enjuanes L . Severe acute respiratory syndrome virus (SARS-CoV) that lacks the envelope (E) gene (rSARS-CoV-ΔE) is. (csic.es)
  • Viral pneumonias other than the one caused by SARS-CoV-2 virus that causes COVID-19 are usually not very serious, but they can be life-threatening in very old and very young patients and in people whose immune systems are weak. (emedicinehealth.com)
  • The severe acute respiratory syndrome coronavirus papain-like protease (SARS-CoV PLpro) is involved in the processing of the viral polyprotein and, thereby, contributes to the biogenesis of the virus replication complex. (asm.org)
  • SARS-CoV was identified in 2003 as the cause of an outbreak of severe acute respiratory syndrome (SARS) that began in China near the end of 2002. (merckmanuals.com)
  • COVID-19 is an acute respiratory illness that can be severe and is caused by a newly identified coronavirus officially named SARS-CoV-2. (merckmanuals.com)
  • The coronavirus disease 2019 (COVID-19) pandemic is caused by the novel beta coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). (news-medical.net)
  • It is known that the SARS-CoV-2 antagonizes interferon (signaling proteins released in response to viral infection) induction. (news-medical.net)
  • Upon SARS-CoV-2 infection, what are the changes occurring on the surface of the host cell? (news-medical.net)
  • To address this, and a team of researchers undertook a study exploring the natural killer (NK) cells and their role during a SARS-CoV-2 infection. (news-medical.net)
  • Spike antibodies play a crucial role in the defense against the SARS-CoV-2 infection. (news-medical.net)
  • ADCC is an important function in COVID-19 and is strongly induced following infection with SARS-CoV-2. (news-medical.net)
  • The basic reproduction number of severe acute respiratory syndrome-related coronavirus (SARS-CoV) was between 2.2 and 3.7, but super-spreading events (highly efficient transmission of the virus) occurred in some hospital settings. (wikipedia.org)
  • A limited number of SARS-CoV attenuating modifications have been described, including mutations, and partial or complete gene deletions affecting the replicase, like the nonstructural proteins (nsp1 or nsp2), or the structural genes, and drastic changes in the sequences that regulate the expression of viral subgenomic mRNAs. (csic.es)
  • In this study, we aim to analyze how smoking may affect the SARS-CoV-2 infection rate. (mdpi.com)
  • COVID-19 is the respiratory illness caused by the SARS-CoV-2 virus that is currently affecting millions of people worldwide and putting extraordinary pressure on public health systems everywhere. (mdpi.com)
  • Human pathogens in the Orthomyxoviridae and Coronaviridae families, especially pandemic H1N1 and avian H5N1 influenza A viruses and severe acute respiratory syndrome coronavirus (SARS-CoV), were investigated. (osti.gov)
  • Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of coronavirus disease 2019 (COVID-19). (nature.com)
  • In the absence of experimental data from physiologically relevant animal models, our knowledge of the trafficking signals displayed by distinct vascular beds and epithelial cell layers in response to infection by SARS-CoV-2 is still incomplete. (nature.com)
  • However, SARS-CoV-2 and influenza virus elicit partially conserved inflammatory responses in the different respiratory epithelial cells encountered early in infection and may trigger partially overlapping combinations of trafficking signals in nearby blood vessels. (nature.com)
  • Here, we review the molecular signals orchestrating leukocyte trafficking to airway and lung compartments during primary pneumotropic influenza virus infections and discuss potential similarities to distinct courses of primary SARS-CoV-2 infections. (nature.com)
  • Shown are the major cell types (ciliated epithelial cells, goblet cells and basal cells) that form the epithelial layers of the nasal airway, lower airways and alveoli, which are targeted by respiratory viruses such as influenza virus and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). (nature.com)
  • Severe COVID‐19 represents viral pneumonia from severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection leading to ARDS. (mja.com.au)
  • SARS‐CoV‐2 infection can be confirmed by positive detection of viral RNA in nasopharyngeal secretions using a specific PCR test. (mja.com.au)
  • 2 - 5 Unlike with other viral respiratory infections, children do not seem to be a major vector of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission, with most pediatric cases described inside familial clusters 6 and no documentation of child-to-child or child-to-adult transmission. (aappublications.org)
  • 16 years old with SARS-CoV-2 infection were identified by means of the Geneva University Hospital's surveillance network (Switzerland). (aappublications.org)
  • SARS-CoV-2 ( severe acute respiratory syndrome coronavirus type 2) ist ein neues Beta-Coronavirus, das Anfang 2020 als Auslöser von COVID-19 identifiziert wurde. (rki.de)
  • CORONAVIRUS DISEASE-2019 (COVID-19) causing severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) was identified in Wuhan 2019 and has since swept the world as a pandemic. (nursingcenter.com)
  • 1 SARS-CoV-2 transmits primarily through respiratory droplets. (nursingcenter.com)
  • Patients with SARS-CoV-2 can have multiorgan complications, including but not limited to, cardiac injury, acute respiratory distress syndrome (ARDS), arrhythmias, thromboses, infarcts, and secondary infections, which have been reviewed and discussed in detail here in a system-wise fashion. (nursingcenter.com)
  • In regard to treatment, while corticosteroid is effective for CRS in other clinical settings, its use is being avoided as it might exacerbate SARS-CoV-2-associated lung injury and prolong viral shedding. (nursingcenter.com)
  • RT-PCR: negative for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral RNA (co-infections are possible). (bmj.com)
  • When SARS-CoV-2 and influenza viruses are co-circulating, test for both viruses in all hospitalised patients with acute respiratory illness, and only test for influenza virus in outpatients with acute respiratory illness if the results will change clinical management of the patient. (bmj.com)
  • Currently, Atea is focused on the development of orally- available, potent, and selective purine nucleotide and nucleoside prodrugs for difficult-to-treat, life-threatening viral infections, including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes COVID-19, hepatitis C virus (HCV) infection, dengue virus, and respiratory syncytial virus (RSV). (yahoo.com)
  • Clinical symptoms suggest SARS-CoV-2 infection with typical ground glass like a lung in computed tomography. (frontiersin.org)
  • SARS-CoV-2 infection was serologically confirmed by the presence of anti-SARS-CoV-2 specific antibodies in patients' serum. (frontiersin.org)
  • Serum antibody detection confirmed SARS-CoV-2 infection. (frontiersin.org)
  • The Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is thought to be transmitted through respiratory droplets and direct contact with the novel coronavirus disease (COVID-19) patients ( 1 ). (frontiersin.org)
  • The COVID-19-related symptoms are not specific and studies reported about 40% of the confirmed cases of SARS-CoV-2 infection were asymptomatic at the early stage of infection ( 2 ). (frontiersin.org)
  • The symptomatic patients produced nearly 50% false-negative RT-qPCT for SARS-CoV-2 ribonucleic acid ( 3 ), which brings complexity and may delay diagnosis and treatment which in turn may lead to considerably increased spread of infection. (frontiersin.org)
  • To make a definite diagnosis for SARS-CoV-2 infection, we reported a case of COVID-19 patient with consistently negative or low-doses of SARS-CoV-2 RNA from oropharyngeal swabs and sputum samples during the whole course of illness. (frontiersin.org)
  • Finally, serum antibody detection confirmed SARS-CoV-2 infection, which demonstrates an alternative diagnostic method for COVID-19. (frontiersin.org)
  • Pneumonia is also closely associated with viral infections such as the SARS coronavirus (SARS-CoV), the avian influenza A (H5N1) virus and the pandemic influenza A (H1N1) virus. (naturalnews.com)
  • A response has come from China to the respiratory disease caused by the new coronavirus (SARS-CoV-2) that emerged in December 2019 in this country. (abovetopsecret.com)
  • We will furthermore capture co-circulation of SARS-CoV-2 with other respiratory viruses, including influenza viruses, allowing a valuable comparative approach to be taken in our clinical, virological and immunological analyses. (rochester.edu)
  • A novel strain of coronavirus (referred to as 2019-nCoV or SARS-CoV-2), which causes the sometimes severe respiratory infection COVID-19, was first identified in Wuhan city, China, toward the end of 2019 [ 1 ]. (springer.com)
  • Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), emerged in Wuhan, China, in December 2019. (ersjournals.com)
  • The target of Pritumumab, cell surface vimentin, has been implicated in the replication of coronavirus, specifically in Severe acute respiratory syndrome coronavirus (SARS-CoV). (wikipedia.org)
  • During the ongoing coronavirus disease 2019 (COVID-19) outbreak, robust detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a key element for clinical management and to interrupt transmission chains. (asm.org)
  • Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of an ongoing pandemic that has infected over 36 million and killed over 1 million people. (asm.org)
  • The distribution of upper respiratory viral loads (VL) in asymptomatic children infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is unknown. (asm.org)
  • An ongoing pandemic of coronavirus disease (COVID-19) is caused by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). (medscape.com)
  • We report clinicopathologic, immunohistochemical, and electron microscopic findings in tissues from 8 fatal laboratory-confirmed cases of SARS-CoV-2 infection in the United States. (medscape.com)
  • The ongoing global pandemic of coronavirus disease (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), was identified in Wuhan, Hubei Province, China, and has spread rapidly around the world. (medscape.com)
  • SARS-CoV-2 belongs to the group of betacoronaviruses that includes severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV), which can infect the lower respiratory tract and cause a severe and fatal respiratory syndrome in humans. (medscape.com)
  • This mechanism has recently been exemplified by the discovery of new pathogenic viruses, such as the novel severe acute respiratory syndrome corona virus-2 (SARS-CoV-2) pandemic, Middle-East respiratory syndrome-coronavirus epidemic in Saudi Arabia, and the deadly outbreak of Ebola in West Africa. (medworm.com)
  • The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) as a global phenomenon has presented clinicians around the world with multiple challenges. (smw.ch)
  • Joint and muscle pain is a common symptom seen in many viral infections and we read with interest the report by López-González et al who described four patients with severe acute respiratory syndrome coronavirus-2 (SARS-Cov-2) pos who developed monoarthritis or oligoarthritis after hospitalisation related to crystals deposition disease confirmed by synovial fluid assessment. (bmj.com)
  • 1 However, no data are available on polyarthritis onset after SARS-CoV-2 infection neither on its impact on pre-existing chronic joint diseases, as rheumatoid arthritis (RA), in terms of clinical worsening or remission loss. (bmj.com)
  • In our hospital, during the SARS-CoV-2 pandemic, we investigated the synovial tissue (ST) characteristics in a patient (#1) who had joint pain complicated with polyarthritis development as first symptoms of SARS-CoV-2 infection and in a patient (#2) with pre-existing anticitrullinated peptide antibody (ACPA)/rheumatoid factor pos RA in stable remission who experienced severe pulmonary distress and joint symptoms worsening after SARS-CoV-2 infection. (bmj.com)
  • A-T) Assessment and management of arthritis in patients with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2 pos ). (bmj.com)
  • The newest coronavirus disease COVID-19 is a highly transmittable and pathogenic viral infection caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which emerged in Wuhan, China and spread around the world. (egms.de)
  • Four of these coronaviruses are known to be the causative agents of common colds (HCoV-229E, HCoV-NL63, HCoV-OC43 and HCoV-HKU1), which usually only result in milder infections, but the coronaviruses MERS-CoV (MERS: Middle East Respiratory Syndrome) SARS-CoV and SARS-CoV-2 have claimed many lives [3] . (egms.de)
  • Due to widespread expression of the type I IFN receptor (IFNAR) in immune cells, IFN-α/β responses can result in immunopathology during viral infections, including influenza virus and severe acute respiratory syndrome coronavirus (SARS-CoV-1) ( 1 - 4 ). (sciencemag.org)
  • A 2017 study in mice showed that an injection of remdesivir before or after severe acute respiratory syndrome coronavirus (SARS-CoV) infection decreased weight loss and viral load in the lung and increased lung function (see "Distillery" ). (biocentury.com)
  • The recent global outbreak of coronavirus diseases (COVID-19) caused by the severe acute respiratory syndrome coronavirus (SARS-CoV-2) serves as a stark reminder of the imminent threat of unexpected pathogens. (sartorius.com)
  • Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread to more than 200 countries and regions globally. (nature.com)
  • SARS-CoV-2 is thought to spread mainly through respiratory droplets and close contact. (nature.com)
  • Moreover, SARS-CoV-2 infection reportedly alters intestinal microbiota, which correlated with the expression of inflammatory factors. (nature.com)
  • Furthermore, multiple in vitro and in vivo animal studies have provided direct evidence of intestinal infection by SARS-CoV-2. (nature.com)
  • These lines of evidence highlight the nature of SARS-CoV-2 gastrointestinal infection and its potential faecal-oral transmission. (nature.com)
  • We also discuss how SARS-CoV-2 gastrointestinal infection might occur and the current evidence and future studies needed to establish the occurrence of faecal-oral transmission. (nature.com)
  • In December 2019, an outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection was reported in several hospitals in Wuhan (Hubei Province, China) 3 . (nature.com)
  • They mainly infect the respiratory tract through attachment to the angiotensin-converting enzyme 2 (ACE2) receptor (SARS-CoV and SARS-CoV-2) or dipeptidyl peptidase 4 (DPP4) receptor (MERS-CoV) 1 , 5 . (nature.com)
  • These events, in severe cases, lead to acute lung injury and acute respiratory distress syndrome, which are the leading causes of death during SARS-CoV-2 infection 9 . (nature.com)
  • Most studies have focused on SARS-CoV-2 infection and clinical symptoms in the respiratory tract. (nature.com)
  • The Middle East Respiratory Syndrome (Mers-CoV) and Severe Acute Respiratory Syndrome (Sars-CoV) had fatality rates of 34-36 percent and 10-12 percent, he added. (yahoo.com)
  • Coronaviruses are a large family of viruses ranging from the common cold to more serious infections such as Mers-CoV and Sars-CoV. (yahoo.com)
  • It's part of a family of viruses that includes germs responsible for the common cold as well as much more serious viral infections like severe acute respiratory syndrome (SARS-CoV) and has been causing many people to become ill very quickly.1 Reports of "coronavirus" have caused health anxiety to flare, and many people are worried and fearful about what might happen because of it. (healthyplace.com)
  • In this analysis of a real-world dataset of positive severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) test results after inoculation with the BNT162b2 messenger RNA vaccine, we found that the viral load was substantially reduced for infections occurring 12 37 d after the first dose of vaccine. (mobileread.com)
  • Patients with severe forms of COVID-19 often develop acute respiratory distress syndrome (ARDS) associated with high levels of proinflammatory cytokines and damage of lungs and other organs. (clinicaltrials.gov)
  • Indicated in patients with respiratory distress and cyanosis. (bmj.com)
  • Final stage is characterised by diffuse alveolar damage pattern corresponding to acute respiratory distress syndrome (ARDS). (eurorad.org)
  • Coronavirus disease-2019 (COVID-19) creates severe respiratory distress and often a cascade of other systemic complications impacting several organ systems. (nursingcenter.com)
  • A new virus that causes severe breathing distress and kidney failure elicits a distinctive airway cell response to allow it to multiply. (infectioncontroltoday.com)
  • H1N1 was responsible for 18,000 deaths, which was caused by viral pneumonia and acute respiratory distress syndrome. (naturalnews.com)
  • Most pandemic deaths were associated with either an aggressive bronchopneumonia, in which bacteria could be cultivated from lung tissue at autopsy, or with a severe acute respiratory distress-like syndrome (ARDS) characterized by blue-grey facial discoloration and excessive fluid in the lungs. (innovations-report.com)
  • Severe deficiency of vitamin D was found in patients with ARDS (Acute Respiratory Distress Syndrome), the cause of fatality during the past coronavirus infections. (businessworld.in)
  • Epithelial loss contributes to acute respiratory distress syndrome, pneumonia, and increased susceptibility to bacterial superinfections. (sciencemag.org)
  • This period is followed by a syndrome of 'atypical' pneumonia , including dry cough , and progressively worsening shortness of breath with poor oxygenation. (medicinenet.com)
  • Seventeen years after the severe acute respiratory syndrome (SARS) epidemic, an outbreak of pneumonia, now called coronavirus disease (COVID-19), was reported in Wuhan, China. (cdc.gov)
  • Is Viral Pneumonia Contagious? (emedicinehealth.com)
  • A number of different viruses cause viral pneumonia that isn't usually serious, including the flu, but most concerning is the deadly pandemic COVID-19 coronavirus that kills largely through attacking the lungs. (emedicinehealth.com)
  • Pneumonia is an infection or inflammation of the lungs . (emedicinehealth.com)
  • The severity of pneumonia depends on which organism is causing the infection and the immune response of the individual to that infection. (emedicinehealth.com)
  • The deadly pandemic COVID-19 coronavirus causes severe lung symptoms including pneumonia in about 16% to 20% of the people who contract it. (emedicinehealth.com)
  • Another two of the most publicized viral infections causing pneumonia are SARS and H1N1 swine flu . (emedicinehealth.com)
  • Viral pneumonia can be caused by influenza virus, respiratory syncytial virus (RSV), and the herpes or varicella viruses as well as those that cause the common cold (parainfluenza, coronaviruses, and adenoviruses ). (emedicinehealth.com)
  • What Are Viral Pneumonia Symptoms? (emedicinehealth.com)
  • How Is Viral Pneumonia Diagnosed? (emedicinehealth.com)
  • Coronaviruses are a large family of viruses that cause respiratory illness ranging in severity from the common cold to fatal pneumonia. (merckmanuals.com)
  • HCoV are now known to be involved in more serious respiratory diseases, i.e. bronchitis, bronchiolitis or pneumonia, especially in young children and neonates, elderly people and immunosuppressed patients. (mdpi.com)
  • The severe acute respiratory syndrome (SARS) coronavirus (CoV) was identified as the etiological agent of an acute respiratory disease causing atypical pneumonia and diarrhea with high mortality. (csic.es)
  • Its manifestations can be viewed as a combination of the two processes, namely viral pneumonia and ARDS. (mja.com.au)
  • Bronchiolitis obliterans organizing pneumonia (BOOP) is a chronic respiratory disease. (hindawi.com)
  • The biotechnology company has developed a number of award winning inventions that have helped to detect and tackle illnesses such as Avian Influenza (AI), a flu infection in birds that can affect humans, foot-and-mouth disease (FMD), a viral infection in hoofed animals, and Severe Acute Respiratory Syndrome (SARS), a form of pneumonia. (wipo.int)
  • Severe cases show infection pneumonia, severe acute respiratory syndrome, kidney failure and even death. (eurorad.org)
  • Signs vary from common viral infection symptoms to pneumonia, severe acute respiratory syndrome, kidney failure and even death. (eurorad.org)
  • Differentiating viral from bacterial pneumonia. (bmj.com)
  • Natural News ) About 200 million cases of viral pneumonia occur every year, according to a recent review published in The Lancet . (naturalnews.com)
  • Researchers from Turku University Hospital in Finland and the University of Otago in New Zealand discussed several causes of viral pneumonia and how the infection is linked to other respiratory diseases, such as Severe Acute Respiratory Syndrome (SARS) and avian influenza. (naturalnews.com)
  • However, infants, children and adults over 65 years old have a higher risk of developing severe pneumonia than others. (naturalnews.com)
  • Pneumonia is a viral or bacterial infection of the lungs that causes the air sacs to become inflamed. (naturalnews.com)
  • Individuals with severe pneumonia may experience difficulty breathing, chest pain and high fever. (naturalnews.com)
  • Meanwhile, immunocompromised individuals, such as those with existing lung conditions, cardiovascular disease or chronic ailments, may also have a higher risk of severe pneumonia. (naturalnews.com)
  • According to the researchers, certain viruses and respiratory infections can worsen the symptoms of pneumonia. (naturalnews.com)
  • During the SARS outbreak in 2003, experts observed that infected individuals showed symptoms of severe pneumonia and lung injury. (naturalnews.com)
  • Common symptoms of the H5N1 infection included multiple organ failure and severe pneumonia, which eventually progressed to acute respiratory failure. (naturalnews.com)
  • As such, children and older adults in developing countries are more at risk of developing severe or potentially fatal pneumonia. (naturalnews.com)
  • Pneumonia is closely associated with various microorganisms and viruses, which have been shown to cause severe and life-threatening symptoms in immunocompromised individuals. (naturalnews.com)
  • Viral respiratory infections from severe acute respiratory syndrome coronavirus 2 often present with similar signs and symptoms of a bacterial pneumonia, raising the concern for a bacterial coinfection. (pharmacytimes.com)
  • Its genome is closest to that of severe acute respiratory syndrome-related coronaviruses from horseshoe bats, and its receptor-binding domain is closest to that of pangolin viruses. (cdc.gov)
  • A number of DNA and RNA viruses encode proteins that target critical cell cycle regulators to achieve cellular conditions that are beneficial for viral replication. (springer.com)
  • Indeed, human influenza type A and B viruses are responsible for annual flu epidemics marked by up to 1 billion infections, 3-5 million severe cases and 300,000-650,000 deaths worldwide, with an huge economic burden in terms of medical visits, hospitalizations, work/school absenteeism. (frontiersin.org)
  • Owing to viral reassortment, the genetic baggage of progeny viruses does not exactly match that of one of the "parental" strains but a combination of both. (frontiersin.org)
  • While most respiratory viruses are more infectious when a patient is symptomatic, viral, epidemiology and modeling evidence suggest that also pre-symptomatic and asymptomatic individuals are able to transmit the infection. (clinicaltrials.gov)
  • Mucosal NK cells play a pivotal role in early protection through their cytolytic function and IFN γ production against bacteria, fungi, viruses, and parasitic infections. (hindawi.com)
  • Live attenuated viruses have generally proven to be the most effective vaccines against viral infections. (csic.es)
  • Using molecular biological techniques, the H5 Kit has been used to detect viruses such as AI that cause widespread flu infections and death around the world. (wipo.int)
  • Coronaviruses are a family of RNA viruses that cause illness ranging from the common cold to severe diseases. (eurorad.org)
  • Barenfanger J, Drake C, Leon N, Mueller T, Troutt T (2000) Clinical and financial benefits of rapid detection of respiratory viruses: an outcomes study. (springer.com)
  • Leveraging the Company's deep understanding of antiviral drug development, nucleoside biology, and medicinal chemistry, Atea has built a proprietary nucleotide and nucleoside prodrug platform to develop novel product candidates to treat single stranded ribonucleic acid, or ssRNA, viruses, which are a prevalent cause of severe viral diseases. (yahoo.com)
  • Emerging and re-emerging viral infections, which include outbreaks of previously unknown pathogens or new strains of known viruses, continue to pose significant threats and challenges to human well-being globally. (westernschools.com)
  • Knowledge of the origin, pathogenesis, and diagnosis of these viruses may aid in reducing the prevalence of the infections they cause. (westernschools.com)
  • Regarding viruses, for reasons probably partly identical involving alkalinisation by chloroquine of the phagolysosome, several studies have shown the effectiveness of this molecule, including against coronaviruses among which is the severe acute respiratory syndrome (SARS)-associated coronavirus. (abovetopsecret.com)
  • The technique is yielding insight on viruses - such as RSV, human influenza, hepatitis C, West Nile virus and severe acute respiratory syndrome (SARS) -- that replicate with the help of proteins encoded by ribonucleic acid (RNA) inside the cell. (innovations-report.com)
  • 3 4 Cardiovascular diseases (CVDs) are known to be triggered by acute respiratory infections caused by viruses (eg, influenza and respiratory syncytial virus) or bacteria. (bmj.com)
  • During infection with respiratory viruses, disease severity is linked to lung epithelial destruction, due to both cytopathic viral effects and immune-mediated damage. (sciencemag.org)
  • Cell entry of enveloped viruses requires a wide-fusion-pore mechanism, involving clustering of fusion-activated proteins and fluidization of the plasma membrane and viral envelope. (portlandpress.com)
  • Following attachment and adsorption of viral particles to specific receptors on host cells, enveloped viruses must enter the host cell by making a fusion pore, fusing their own lipid bilayer envelope coat with that of the plasma cell membrane. (portlandpress.com)
  • Because the technology is so broad-spectrum, it could potentially also be used to combat outbreaks of new viruses, such as the 2003 SARS (severe acute respiratory syndrome) outbreak, Rider said. (ei-resource.org)
  • Impaired ciliary movement in the respiratory tract may impede the clearance of harmful pathogens and foreign bodies inhaled. (news-medical.net)
  • Although microbiologically contaminated surfaces can serve as reservoirs of potential pathogens, these surfaces generally are not directly associated with transmission of infections to either staff or patients. (cdc.gov)
  • These coronaviruses that cause severe respiratory infections are transmitted from animals to humans (zoonotic pathogens). (merckmanuals.com)
  • The successful viral pathogens can antagonize these immune pathways with genes that inhibit the key players in the immune system. (news-medical.net)
  • The question of how they come to reside in their tissues and published data on their function against pathogens during mucosal infection are discussed. (hindawi.com)
  • New challenges have emerged as previously unrecognised viral infections have emerged, and microbial resistance to antibiotics has developed in many old pathogens. (mja.com.au)
  • Here, in this review information regarding almost all the effective LAMP techniques which is developed so far for diagnosis of numerous viral pathogens is presented. (springer.com)
  • Adding to the dangers posed by emerging viral diseases is the appearance of new strains of many known pathogens in more virulent forms. (westernschools.com)
  • Respiratory syncytial virus (RSV) is most common in the spring. (emedicinehealth.com)
  • American Academy of Pediatrics Committee on Infectious Diseases and Committee on Fetus Newborn (2003) Revised indications for the use of palivizumab and respiratory syncytial virus immune globulin intravenous for the prevention of respiratory syncytial virus infections. (springer.com)
  • Scientists have used a powerful molecular imaging technique to see inside living cells infected with the most pervasive and potentially fatal childhood respiratory virus known to medicine -- respiratory syncytial virus (RSV). (innovations-report.com)
  • Along with the other serious coronavirus infections of severe acute respiratory syndrome and Middle East respiratory syndrome, which also cause ARDS, COVID‐19 represents an ongoing global threat as this virus family has the potential to mutate and infect non‐immune populations. (mja.com.au)
  • It is therefore important to monitor patients for the development of ARDS as their COVID‐19 infection progresses. (mja.com.au)
  • Respiratory rate and SpO 2 are two important parameters for judging patients' clinical condition and allowing early recognition of ARDS. (mja.com.au)
  • The investigation underscores the need for monitoring fever and respiratory symptoms in hospitalized patients and visitors, particularly after a decline in the number of reported SARS cases. (cdc.gov)
  • 38°C), a chest radiograph or a computed tomographic image of the thorax showing evidence of consolidation with or without respiratory symptoms, and a history of close contact with a person in whom SARS had been diagnosed. (bmj.com)
  • Five percent of those with severe symptoms need a ventilator to breathe, as of March, 2020. (emedicinehealth.com)
  • In addition to the respiratory symptoms, you can get headache , fever , and muscle aches. (emedicinehealth.com)
  • Adenovirus and parainfluenza viral pneumonias are often accompanied by cold symptoms such as runny nose and pinkeye ( conjunctivitis ). (emedicinehealth.com)
  • Four of these 7 human coronavirus infections involve mild upper respiratory tract illness that causes symptoms of the common cold . (merckmanuals.com)
  • The virus is usually transmitted by a person with symptoms of the infection, but it can be transmitted by people before they exhibit symptoms (presymptomatic) and even by people who are infected but never develop symptoms (asymptomatic). (merckmanuals.com)
  • HHCs were considered suspect if they had fever or acute respiratory symptoms, as per the Swiss Federal Office for Public Health's case definition 9 ( Supplemental Information ). (aappublications.org)
  • Differentiating COVID-19 from community-acquired respiratory tract infections is not possible from signs and symptoms. (bmj.com)
  • The patient reported not having traveled or having resided in and/or around Wuhan or other communities with reported cases or not having been exposed to other patients with fever or respiratory symptoms during the 14 days before disease onset. (frontiersin.org)
  • According to a meta-analysis of data from a Hong Kong cohort published in 2020, 17.6% of patients with COVID-19 have gastrointestinal symptoms 15 and 48.1% of faecal samples from patients with COVID-19 have tested positive for viral RNA 15 . (nature.com)
  • These 29 individuals showed symptoms of respiratory infection but have no history of travel to China. (yahoo.com)
  • The common signs of coronavirus infection include respiratory symptoms, fever, cough, shortness of breath and breathing difficulty. (yahoo.com)
  • Like most respiratory illnesses, SARS is spread mainly through contact with infected saliva or droplets from coughing. (cigna.com)
  • This infection can be spread easily from close person-to-person contact (such as living in the same household) via respiratory droplets that come in contact with skin or mucous membranes (eyes, mouth, or nose). (medicinenet.com)
  • A mask keeps others safe from your respiratory droplets. (capitolfax.com)
  • COVID-19 is mainly spread through respiratory droplets of infected persons. (clinicaltrials.gov)
  • COVID-19 is mainly spread from person to person through respiratory droplets that are produced when an infected person coughs, sneezes, sings, exercises, or talks. (merckmanuals.com)
  • Severe acute respiratory syndrome (SARS) is a respiratory illness that first infected people in parts of Asia, North America, and Europe in late 2002 and early 2003. (cigna.com)
  • SARS is caused by a type of coronavirus, which can cause mild to moderate upper respiratory illness, such as the common cold. (cigna.com)
  • SARS is an infectious respiratory illness caused by a coronavirus. (medicinenet.com)
  • Background Coronavirus disease 2019 (COVID-19) is an infectious disease characterized by severe respiratory illness which can lead to multi-organ damage. (clinicaltrials.gov)
  • 5-8 The etiology of CRS includes various infections, drugs, and critical illness. (nursingcenter.com)
  • The severe acute respiratory syndrome (SARS) is a serious, sometimes fatal, illness caused by a virus called coronavirus. (annals.org)
  • The so-called superbugs that cause these infections thrive in hospitals and medical facilities, putting all patients - whether they're getting care for a minor illness or major surgery - at risk. (merck.com)
  • The patients at greatest risk from superbugs are the ones who are already more vulnerable to illness from viral lung infections like influenza, severe acute respiratory syndrome (SARS), and COVID-19. (merck.com)
  • Here we report a case that showed 5 consecutive negative and 1 low-viral- dose RT-qPCR results during illness spanning over 20 days. (frontiersin.org)
  • Surprisingly, as a barber and a housewife staying at home for the first 2 weeks after the onset of illness, none of the close contacts were infected, showing a case of low viral load and low infectivity in this patient. (frontiersin.org)
  • COVID-19 is a novel coronavirus infection that can cause a severe respiratory illness and has been declared a pandemic by the World Health Organization (WHO). (springer.com)
  • The identification of a coronavirus as the infectious agent of severe acute respiratory syndrome (SARS) and the rapid sequencing of its genome have led to a renewed interest in coronaviruses ( 34 ). (asm.org)
  • The Coronaviridae family, an enveloped RNA virus family, and, more particularly, human coronaviruses (HCoV), were historically known to be responsible for a large portion of common colds and other upper respiratory tract infections. (mdpi.com)
  • An outbreak of severe acute respiratory syndrome (SARS) has recently been reported from Hong Kong. (bmj.com)
  • During the 2003 outbreak, approximately 25% of people had severe respiratory failure and 10% died. (medicinenet.com)
  • Epidemiological data from the 2002-2003 SARS epidemic and recent Middle East respiratory syndrome outbreak indicate that there may be sex-dependent differences in disease outcomes. (jimmunol.org)
  • Severe acute respiratory syndrome (SARS), which is also caused by a virus in the coronavirus family, had a major outbreak in 2003 with an estimated 8,000 cases and 750 deaths. (emedicinehealth.com)
  • McGeer has led investigations into the severe acute respiratory syndrome outbreak in Toronto and worked alongside Donald Low. (wikipedia.org)
  • Severe Acute Respiratory Syndrome (SARS) is a respiratory infection that was first identified in a 2003 outbreak. (denverhealth.org)
  • Few studies have fully described what happened during the outbreak and the rapid spread of the infection. (annals.org)
  • Although the majority of recent EIDs have been viral, bacterial infections are also a threat, with the devastating cholera epidemic in Haiti, the foodborne Escherichia coli O104:H4 outbreak in Germany in 2011, and the invasive nontyphoidal Salmonella in Africa representing prominent examples. (pnas.org)
  • The suddenness of the outbreak provided a critical test of medical systems, infection control policies, and tested many national disease response and crisis management abilities. (sciencebase.com)
  • The authors cite several studies involving lymphopenia during viral infections, including the 2003 outbreak of severe acute respiratory syndrome (SARS), for which they have cited one of my papers ( 2 ), which specifically asked the question, "What caused lymphopenia in SARS? (jimmunol.org)
  • Severe acute respiratory syndrome (SARS) was first recognized in Toronto in a woman who returned from Hong Kong on February 23, 2003. (cdc.gov)
  • A notable recent example was the Severe Acute Respiratory Syndrome (SARS) pandemic in 2003 where up to 75% of infections from Hong Kong and Singapore were linked to super-spreaders. (livescience.com)
  • A cluster of cases of severe acute respiratory syndrome in Hong Kong. (bmj.com)
  • The summary below is from the full report titled "The Epidemiology of Severe Acute Respiratory Syndrome in the 2003 Hong Kong Epidemic: An Analysis of All 1755 Patients. (annals.org)
  • We review the melatonergic pathway role in viral infections, emphasizing influenza and covid-19 infections. (nih.gov)
  • Focussing on immune regulators has treatment implications for covid-19 and other viral infections. (nih.gov)
  • Answers to these questions are essential to forming a general understanding of viral pathogenesis, which helps us develop effective prevention and treatment strategies for COVID-19. (news-medical.net)
  • The sensitive assays that detect viral RNA and protein in COVID-19 patient samples showed sino-nasopharyngeal, airway, and alveolar cell infection. (news-medical.net)
  • However, in some people, they develop a hyper-inflammatory response, which is a clinical feature in severe COVID-19. (news-medical.net)
  • Exosomes derived from bone marrow mesenchymal stem cells as treatment for severe COVID-19. (cdc.gov)
  • This prospective nonrandomized open-label cohort study addresses the safety and efficacy of exosomes (ExoFlo(TM)) derived from allogeneic bone marrow mesenchymal stem cells as treatment for severe COVID-19. (cdc.gov)
  • In conclusion, owing to its safety profile, capacity to restore oxygenation, downregulate cytokine storm, and reconstitute immunity, ExoFlo is a promising therapeutic candidate for severe COVID-19. (cdc.gov)
  • This study will explore whether a daily supplement of glycine, a substance that has antiinflammatory, cytoprotective, and endothelium-protecting effects, can improve mortality, as well as clinical and biochemical parameters, in patients with severe COVID-19 who initiate mechanical ventilatory support. (clinicaltrials.gov)
  • In December 2019, Coronavirus infection (COVID-19) was identified as causing serious respiratory infection in humans. (clinicaltrials.gov)
  • Due its physiologic immune suppression, pregnancy is a vulnerable time for severe respiratory infections including COVID-19. (clinicaltrials.gov)
  • The investigators expect to gain knowledge on the impact of COVID-19 in pregnant women especially if asymptomatic and compare to other respiratory infections. (clinicaltrials.gov)
  • Early COVID-19 infections were linked to a live animal market in Wuhan, China, suggesting that the virus was transmitted from animals being sold as exotic food to humans. (merckmanuals.com)
  • People may also get a COVID-19 infection by touching something that has the virus on it and then touching their own mouth, nose, or eyes. (merckmanuals.com)
  • Because lack of ADCC is linked strongly with severe COVID-19, the virus variants may therefore evolve to evade ADCC responses as well as neutralizing responses. (news-medical.net)
  • As in other respiratory infections, leukocyte recruitment to the respiratory system in people with COVID-19 is orchestrated by specific leukocyte trafficking molecules, and when uncontrolled and excessive it results in various pathological complications, both in the lungs and in other organs. (nature.com)
  • These multiple molecular pathways are potential targets for therapeutic interventions in patients with severe COVID-19. (nature.com)
  • FRIDAY, April 23, 2021 -- Few cases of severe acute respiratory syndrome coronavirus 2 infections have been reported at skilled nursing facilities among those with at least 14 days since receipt of the second dose of a two-dose COVID-19 vaccine series, according to research published in the April 21 early-release issue of the U.S. Centers for Disease Control and Prevention Morbidity and Mortality Weekly Report . (drugs.com)
  • FRIDAY, April 23, 2021 -- A single dose of human adenovirus type 26 vector encoding full-length severe acute respiratory syndrome coronavirus 2 spike protein protects against moderate- to severe-critical and severe-critical COVID-19, according to a study published online April 21 in the New England Journal of Medicine . (drugs.com)
  • FRIDAY, April 23, 2021 -- COVID-19 in pregnancy is associated with increased severe maternal morbidity and mortality, according to a study published online April 22 in JAMA Pediatrics . (drugs.com)
  • Acute-onset smell and taste disorders in the context of COVID-19: a pilot multicenter PCR-based case-control study. (bmj.com)
  • Only testing can distinguish between influenza infection and COVID-19 and identify co-infection. (bmj.com)
  • Already, some studies have found that 1 in 7 patients hospitalized with COVID-19 has acquired a dangerous secondary bacterial infection, and 50% of patients who have died had such infections. (merck.com)
  • In a perfect world, we would always have new antibiotics to fight emerging antibiotic-resistant infections, ready to use when a crisis like the COVID-19 pandemic strikes. (merck.com)
  • Verifying the presence of viral RNA is the gold standard for the diagnosis of COVID-19. (frontiersin.org)
  • FRIDAY, Aug. 28, 2020 (HealthDay News) -- Severe disease and death appear to be rare among children and young people hospitalized with laboratory-confirmed COVID-19, according to an observational study in the United Kingdom published online Aug. 27 in The BMJ . (healthday.com)
  • FRIDAY, Aug. 28, 2020 (HealthDay News) -- Acute pancreatitis may be a gastrointestinal manifestation of COVID-19, according to research published online Aug. 26 in Gastroenterology . (healthday.com)
  • WEDNESDAY, Sept. 30, 2020 (HealthDay News) -- Health care workers (HCWs) diagnosed with COVID-19 can have a prolonged recovery of viral RNA, which can delay return to work (RTW), according to research published online Aug. 26 in Infection Control & Hospital Epidemiology . (healthday.com)
  • Disease flares can potentially be induced by covid-19, as seen in RDs by most endogenous retroviruses as well as acquired viral infections. (bmj.com)
  • The COVID-19 infection rate was high in patients with active tuberculosis. (ersjournals.com)
  • Tuberculosis (TB), the leading cause of death worldwide from a single infectious agent (1.5 million people per year) [ 2 ], like COVID-19, is mainly transmitted through the respiratory route and affects the lungs. (ersjournals.com)
  • Risk factors such as advanced age and some comorbidities, such as diabetes and chronic respiratory diseases, are associated with poor outcomes in both TB and COVID-19 [ 3 ]. (ersjournals.com)
  • However, only limited information about COVID-19 and active TB co-infection has been reported so far [ 4 - 6 ]. (ersjournals.com)
  • Patients with active TB admitted to the hospital were analysed to assess the impact of COVID-19 on their clinical course, as well as the radiological and laboratory consequences of the co-infection. (ersjournals.com)
  • Among the 24 in-patients diagnosed with active TB, we identified 20 cases with COVID-19 co-infection. (ersjournals.com)
  • Among the 20 TB patients diagnosed with COVID-19 co-infection, 12 (60%) were males and the median (IQR) age was 39 (27-47) years: considering country of birth, the median ages were 37 (27-46) and 48 (47-60) years for foreign-born (85%) and Italian nationals, respectively. (ersjournals.com)
  • People whose blood levels of vitamin D are at least 50- 60 ng/ml, are better protected from the effects of the deadly viral infections, COVID-19 being the present one. (businessworld.in)
  • The primary outcome measure was a composite fatal outcome of severe COVID-19 or death. (bmj.com)
  • Results We included 51 studies with a total of 48 317 patients with confirmed COVID-19 infection. (bmj.com)
  • PTB has been proposed as a potential treatment for COVID-19 and related Viral Infections. (wikipedia.org)
  • Role of probiotics to combat viral infections with emphasis on COVID-19. (medworm.com)
  • Thromboembolic events are recognised complications of viral infection, but the diagnosis of an acute pulmonary thrombotic complication in the context of coronavirus disease 2019 (COVID-19) can be challenging because of the similarities of presentation, logistical considerations of diagnosis in a patient isolated for infection control reasons and the effects of cognitive errors in diagnostic reasoning. (smw.ch)
  • The haemostasis parameters we observed, including increased levels of von Willebrand factor and factor VIII, point towards a relevant involvement of endothelial cells in patients with severe COVID-19. (smw.ch)
  • Emerging and cumulative international data from clinical observations [ 1 - 4 ] continue to contribute to the understanding of the underlying pathophysiology and point towards a distinctive coagulopathy associated with severe cases of COVID-19. (smw.ch)
  • Therefore, timing and duration are critical parameters of endogenous IFN action and should be considered carefully for IFN therapeutic strategies against viral infections like influenza and coronavirus disease 2019 (COVID-19). (sciencemag.org)
  • Chloroquine (CQ) and hydroxychloroquine (HCQ) are showing promise as therapeutic treatments for COVID-19 infections. (uncommondescent.com)
  • Her primary areas of research interest are the prevention of healthcare associated infection, the epidemiology of influenza, and adult immunization. (wikipedia.org)
  • Severe acute respiratory syndrome (SARS): epidemiology and clinical features. (bmj.com)
  • As the WHO declared the disease as pandemic by March 11, 2020, health authorities decided to pose a mandatory lockdown since March 20, 2020 in order to prevent rapid propagation of infections and prepare the expansion of health infrastructure. (scielosp.org)
  • The World Bank estimates the anticipated gross domestic product (GDP) cost of a moderately severe global flu pandemic at about 5% of world income (roughly $3.5 trillion-a sum greater than Germany's GDP) ( 11 , 12 ). (pnas.org)
  • We can't predict when or where the next pandemic-triggering virus will emerge, but we can predict that secondary bacterial infections will follow. (merck.com)
  • They propose that the many excess deaths that occurred during the 1918 influenza pandemic resulted from a disease process that began with a severe acute viral infection that spread down the respiratory tree causing severe tissue damage, which was often followed by secondary bacterial invasion. (innovations-report.com)
  • 1 The pandemic arising from severe acute respiratory syndrome coronavirus-2 has rapidly changed our personal and professional outlook. (bmj.com)
  • BOSTON, Nov. 25, 2020 (GLOBE NEWSWIRE) -- Atea Pharmaceuticals, Inc. (Nasdaq: AVIR) ("Atea"), a clinical-stage biopharmaceutical company focused on discovering, developing and commercializing antiviral therapeutics to improve the lives of patients suffering from life-threatening viral infections, today announced that management will participate in a fireside chat at the Evercore ISI 3rd Annual HealthCONx Conference on Thursday, December 3, 2020 at 12:35 p.m. (yahoo.com)
  • Experienced Financial Executive Brings Leadership and Public Company ExpertiseBOSTON, Nov. 06, 2020 (GLOBE NEWSWIRE) -- Atea Pharmaceuticals, Inc. (Nasdaq: AVIR) ("Atea"), a clinical-stage biopharmaceutical company focused on discovering, developing and commercializing antiviral therapeutics to improve the lives of patients suffering from life-threatening viral infections, today announced the appointment of Barbara Duncan to its Board of Directors, where she will also serve as Chair of the Audit Committee. (yahoo.com)
  • TUESDAY, Sept. 29, 2020 (HealthDay News) -- Among young adults with acute myocardial infarction-cardiogenic shock (AMI-CS), women are treated less aggressively and have higher in-hospital mortality than men, according to a study published online Sept. 29 in Circulation: Heart Failure . (healthday.com)
  • The alterations in butyrate and LPS can promote viral replication and host symptom severity via impacts on the melatonergic pathway. (nih.gov)
  • this is thought to increase pools of deoxynucleotides and thus, facilitate viral replication. (springer.com)
  • When known, we describe how these virus-associated effects influence replication of the virus and contribute to diseases associated with infection by that specific virus. (springer.com)
  • Dove B, Brooks G, Bicknell K, Wurm T, Hiscox JA (2006) Cell cycle perturbations induced by infection with the coronavirus infectious bronchitis virus and their effect on virus replication. (springer.com)
  • The 5′ proximal region of the genome containing the replicase gene accounts for approximately two-thirds of the full-length genome and encodes the nonstructural proteins (nsp's) essential for viral replication as large overlapping replicase polyproteins, pp1a (486 kDa) and pp1ab (790 kDa). (asm.org)
  • These molecules in turn activate latent RNase L resulting in viral RNA degradation and the inhibition of viral replication. (creativebiomart.net)
  • Remdesivir is thought to block a key enzyme needed for viral replication. (biocentury.com)
  • As a consequence, the rapid viral replication triggers the release of pro-inflammatory cytokines and/or chemokines and massive infiltration of inflammatory cells 6 , 7 . (nature.com)
  • Canada's National Advisory Committee on Immunization Ontario Provincial Infectious Diseases Advisory Committee, infection control subcommittee, member 2014: Toronto Life, Toronto's 30 Best Doctors 2015: Canadian Medical Association, May Cohen Award for Women Mentors 2016: Association of Medical Microbiology and Infectious Disease Canada, Lifetime Achievement Award Chen, Danny K. (wikipedia.org)
  • Other infectious diseases where this phenomenon has been observed worldwide include outbreaks of tuberculosis, measles, cholera, as well as Ebola viral haemorrhagic fever . (livescience.com)
  • Most of the diseases caused by viral infection are found to be fatal, and the diagnosis is difficult due to confusion with other causative agents. (springer.com)
  • A replay of the webcast will be available for 90 days following the presentation.About Atea PharmaceuticalsAtea Pharmaceuticals is a clinical stage biopharmaceutical company focused on discovering, developing and commercializing therapies to address the unmet medical needs of patients with life-threatening viral diseases. (yahoo.com)
  • It can also be applied for acute infectious diseases such as the Middle East respiratory syndrome and severe acute respiratory syndrome. (koreaherald.com)
  • One of the patients, a five-year-old Chinese boy from Wuhan, was discharged from the Vicente Sotto Memorial Medical Center Friday evening, January 24, shortly after he was cleared of the 2019-nCoV infection based on the laboratory test results from Victoria Infectious Diseases Reference Laboratory in Melbourne, Australia. (yahoo.com)
  • Virology Goodman AG, Tanner BC, Chang ST, Esteban M, Katze MG. Previously we showed that the cellular protein P58(IPK) contributes to viral protein synthesis by decreasing the activity of the anti-viral protein, PKR. (csic.es)
  • Viral, or preexistent, suppression of pineal melatonin disinhibits neutrophil attraction, thereby contributing to an initial "cytokine storm", as well as the regulation of other immune cells. (nih.gov)
  • In contrast, females mount stronger innate and adaptive immune responses and are relatively resistant to virus infections ( 23 , 28 - 30 ). (jimmunol.org)
  • The answer may lie in how the super-spreading individual's immune system handles infection. (livescience.com)
  • One "resistance" mechanism involves the body's immune system fighting off infection to control, if not eliminate, the pathogen. (livescience.com)
  • The immune response includes a cytokine storm that creates many life-threatening problems including coagulopathies, arrhythmias, and secondary infections. (nursingcenter.com)
  • It is known to be an immune system-related disease and has been seen previously in chimeric antigen receptor (CAR) T-cell therapy, sepsis, organ transplantation, and viral infection. (nursingcenter.com)
  • This latent state can be life-long but disease develops when the immune system weakens as a consequence of HIV co-infection, aging or malnutrition [1] . (prolekare.cz)
  • Indeed, among the several hundreds of eggs laid daily by each female schistosome, a large part gets trapped into host tissues and elicits immune responses, such as inflammation and granuloma formation, causing severe disorders, particularly hepatosplenomegaly, hepatic fibrosis and bladder cancer [2] . (prolekare.cz)
  • Collectively, the centers will expand NIAID's influenza surveillance program internationally and in the United States, and will bolster influenza research in key areas, including understanding how the virus causes disease and how the human immune system responds to infection with the virus. (nih.gov)
  • Together, the CEIRS Network offers a unified human surveillance effort designed to gather critical information on the spectrum of disease, risk factors, duration of viral shedding, viral genomics, viral dynamics within and between populations and innate and memory immune responses to infection. (rochester.edu)
  • It has been found that vitamin D deficiency can compromise respiratory immune response to various bacterial and viral infections. (businessworld.in)
  • RxPG] Chinese investigators have revealed that the early presence of interferon-inducible protein 10 (IP-10), an immunoregulatory protein, is a prominent characteristic of the body's immune reaction to the coronavirus that causes severe acute respiratory syndrome (SARS). (rxpgnews.com)
  • The investigators pointed out that immunopathologic injury of host cells triggered by the immune response to virus plays a key role in the pathogenesis of virus infections. (rxpgnews.com)
  • A key question for our community therefore is the extent to which risk of infection a priori, or progression thereafter, are altered for people with RMDs taking immune modifiers, for example, glucocorticoids, biologicals, targeted synthetic disease-modifying anti-rheumatic drugs (DMARDs), or indeed conventional DMARDs. (bmj.com)
  • moreover, on infection, all patients discontinued their immune modifiers without flaring despite intercurrent viral stimulus. (bmj.com)
  • The authors also helpfully point to prior experiences following Middle East respiratory syndrome and severe acute respiratory syndrome outbreaks in which immune suppression, transplantation and cancer did not notably confer poorer outcomes. (bmj.com)
  • The iQue ® Advanced Flow Cytometry Platform can be used for viral research activities such as monitoring host-pathogen interactions, antibody library screening, immune response assessment, epitope mapping, and antibody neutralization studies. (sartorius.com)
  • MERS-CoV was identified in 2012 as the cause of Middle East respiratory syndrome (MERS). (merckmanuals.com)
  • In the last few years, severe acute respiratory syndrome (SARS), West Nile, H5N1, H1N1, Middle East respiratory syndrome (MERS), and Ebola-in addition to Zika-have emerged. (pnas.org)
  • [ 10-18 ] Pathologic evaluation and determination of virus distribution and cellular localization within tissues is crucial to elucidating the pathogenesis of these fatal infections and can help guide development of therapeutic and preventive countermeasures. (medscape.com)
  • Viral infection of both types of epithelial compartments triggers the release of inflammatory cytokines. (nature.com)
  • Angamuthu R, Baskaran S, Gopal DR, Devarajan J, Kathaperumal K (2012) Rapid detection of the Marek's disease viral genome in chicken feathers by loop-mediated isothermal amplification. (springer.com)
  • Also in this study, researchers used confocal microscopy to view very thin sections of the RSV viral genome in live, infected cells. (innovations-report.com)
  • Administration of convalescent plasma, serum, or hyperimmune immunoglobulin may be of clinical benefit for treatment of severe acute respiratory infections (SARIs) of viral etiology. (nih.gov)
  • This therapy should be studied within the context of a well-designed clinical trial or other formal evaluation, including for treatment of Middle East respiratory syndrome coronavirus CoV infection. (nih.gov)
  • The complex relationships between initial infection and the succeeding coordinated antiviral responses occur in the respiratory epithelium, determining clinical outcomes. (news-medical.net)
  • however, as mice aged, there was a steep increase in the susceptibility, such that mice older than 5 mo of age were highly susceptible to MA15 infection ( 17 - 19 ). (jimmunol.org)
  • OAS1 gene mutations are been linked to host susceptibility to viral infection. (creativebiomart.net)
  • Furthermore, OAS1 gene polymorphisms are linked to the susceptibility to severe acute respiratory syndrome. (creativebiomart.net)
  • Rapid aging of the global population will further increase susceptibility, as both ability to fight off infection and efficacy of immunization wane with age. (pnas.org)
  • GL also inhibited cell-to-cell fusion induced by HIV-1 and HTLV-I (human T-cell leukaemia virus type I). However, when cells treated with 1 mg/ml GL were placed in GL-free medium, they showed increased susceptibility to HIV-1 infection and HTLV-I fusion due to enhancement of membrane fluidity. (portlandpress.com)
  • McGeer studies the prevention and management of bacterial and viral infections. (wikipedia.org)
  • This sex-dependent increase in disease severity after pathogenic CoV infection was more pronounced with advancing age ( 20 , 22 ). (jimmunol.org)
  • 8 Furthermore, the presence of underlying CVD increases both the severity of the primary respiratory disease and the risk of developing further complications. (bmj.com)
  • Human nasal, airway and alveolar epithelial cell cultures have shed light on the complexity of the respiratory system. (news-medical.net)
  • The diagnosis was confirmed by an indirect immunofluorescence assay with fetal rhesus kidney cells that were infected with coronavirus and fixed in acetone to detect a serological response to the virus 3 or by a positive viral culture. (bmj.com)
  • So, a highly efficient molecular-based advance detection technique, i.e., loop-mediated isothermal amplification (LAMP) method, is developed for diagnosis of viral infections by various workers. (springer.com)
  • Particular points of interest include identifying typical imaging findings during diagnosis and follow-up stages of the infection, and whether any features might be used as prognostic markers to determine patient outcome. (springer.com)
  • We previously emphasised interest in chloroquine for the treatment of viral infections in this journal, predicting its use in viral infections lacking drugs. (abovetopsecret.com)
  • Nevertheless, the FDA has recently given emergency approval to what had long been a common off-use application for treatment of viral infections. (uncommondescent.com)
  • See how Sartorius' innovative, groundbreaking solutions advance and accelerate your discovery and development of new vaccines against viral infections. (sartorius.com)
  • This review summarizes the state-of-the-art of current antiviral options against influenza infection, with a particular focus on the recent advances of anti-influenza drug repurposing strategies and their potential therapeutic, regulatory and economic benefits. (frontiersin.org)
  • Viral infections cannot be treated with antibiotics and current antiviral drugs have not had any effect. (denverhealth.org)
  • Ultimately, the research could to lead to early and rapid detection of viral infection and the design of new antiviral drugs. (innovations-report.com)
  • IFN-α/β and IFN-λ are induced upon viral recognition and trigger transcription of interferon-stimulated genes with antiviral function in infected and bystander cells. (sciencemag.org)
  • The IFN-λ receptor (IFNLR) is mainly expressed at epithelial barriers, and responses are therefore often characterized by their ability to confer localized antiviral protection at the site of infection, without driving damaging proinflammatory responses associated with IFN-α/β. (sciencemag.org)
  • Translational control during viral infection, investigating the role of severe acute respiratory syndrome non-structural protein 1 and enterovirus 71 internal ribosome entry site. (surrey.ac.uk)
  • This thesis focused on translational control during viral infection, where we investigated the role of Severe Acute Respiratory Syndrome non-structural protein 1 and Enterovirus 71 Internal Ribosome Entry Site in this process. (surrey.ac.uk)
  • As a result, by comparing data from mutant versus wild-type virus and host strains, RNA versus protein differential expression, and infection with genetically similar strains, these data can be used to further investigate genetic and physiological determinants of host responses to viral infection. (osti.gov)
  • Later, and throughout infection, the human coronavirus EMC incites a massive sabotage much greater than that of the SARS virus of many genetic controls of protein production in lung cells grown in the laboratory. (infectioncontroltoday.com)
  • Fluidities of HIV-1 envelopes were always lower than those of plasma membranes, since cholesterol/protein ratios of viral envelopes were higher than those of plasma membranes [ 15 , 17 , 18 ]. (portlandpress.com)
  • First described in Asia in 2002, SARS was discovered in Chinese patients who had fever and severe breathing problems. (annals.org)
  • Such drugs, however, are useless against viral infections, including influenza, the common cold and deadly hemorrhagic fevers such as Ebola. (ei-resource.org)
  • SARS, which emerged in China in late 2002, is a pulmonary infection with a reported fatal outcome of 10% ( 42 ). (asm.org)
  • Sonia Choi, a spokesperson for Gilead Sciences Inc. (NASDAQ:GILD), told BioCentury the company expects to begin enrolling patients mid-February in two trials evaluating remdesivir to treat 2019-nCoV acute respiratory disease. (biocentury.com)
  • The researchers reported that the spike-specific antibodies played only a minor role in ADNKA compared to antibodies to other viral proteins, including ORF3a, Membrane, and Nucleocapsid. (news-medical.net)
  • While viral entry glycoproteins are often found on the infected cell surface and can mediate ADCC when expressed alone, other viral proteins may be the principal mediators of ADCC during infection. (news-medical.net)
  • Fusion occurs via at least two classes of viral proteins in the envelope [ 1 ]. (portlandpress.com)
  • Cell-to- cell fusion, by co-cultivation of HIV-1- or HTLV-I (human T-cell leukaemia virus type I)-infected cells with target CD4-positive cells, also requires the recruitment of viral envelope proteins and receptors to the interface as a virological synapse [ 8 , 9 ]. (portlandpress.com)
  • Males and females respond differently to many RNA and DNA virus infections ( 23 ). (jimmunol.org)
  • Objectives To evaluate the haematological findings of patients with severe acute respiratory syndrome (SARS). (bmj.com)
  • Spontaneous pneumomediastinum in patients with severe acute respiratory syndrome. (bmj.com)
  • See how a potently neutralizing human monoclonal antibody with post-exposure therapeutic activity against ZIKV infection was developed in a mouse model. (sartorius.com)
  • The new disease agent belongs to the betacoronavirus family, as does the severe acute respiratory syndrome virus, SARS. (infectioncontroltoday.com)
  • The team used infection of human bronchial epithelial-derived air-liquid interface (ALI) cultures and single-cell RNA sequencing to arrive at the study findings. (news-medical.net)
  • Events triggered by viral infection of the airway epithelial compartment (left) and of the alveolar epithelial compartment that constitute the lung parenchyma (right). (nature.com)
  • Thus, excessive or prolonged IFN-production aggravates viral infection by impairing lung epithelial regeneration. (sciencemag.org)
  • Despite a growing understanding of immunopathology in respiratory viral infection, it is unknown how IFN responses affect lung epithelial repair. (sciencemag.org)
  • All patients with signs of severe infection should receive blood and sputum cultures to rule out other causes of a lower respiratory tract infection, especially those without a typical epidemiological history for SARS. (bmj.com)
  • Despite its apparent blandness for the collective mindset of an important portion of the society, the intrinsic morbidity and mortality as well as the related deaths because of bacterial superinfections or exacerbation of chronic illnesses, make of influenza infections a major and recurrent global public health concern. (frontiersin.org)
  • Unfortunately, the pipeline of drugs to manage these deadly infections is nearly dry. (merck.com)
  • On a chest X-ray , radiologists will note round, fluffy areas that are produced by the coronavirus infection called globules blocing oxygenation of lung tissue. (emedicinehealth.com)
  • Excessive cytokine signaling frequently exacerbates lung tissue damage during respiratory viral infection. (sciencemag.org)
  • SAR-CoV-2 binds to the human angiotensin-converting enzyme 2 (ACE2) receptor on the surface of cells lining the respiratory tract. (news-medical.net)
  • it binds to the human host angiotensin-converting enzyme 2 (ACE2) receptor, enabling viral entry. (news-medical.net)
  • In this study, they reported that following natural infection, the ADNKA responses are dominated by non-spike antibodies (nucleocapsid, membrane and ORF3a). (news-medical.net)
  • Conventional natural killer cells (NK cells) provide continual surveillance for cancer and rapid responses to infection. (hindawi.com)
  • This program generated 47 transcriptomic and proteomic datasets from 30 studies that investigate in vivo and in vitro host responses to viral infections. (osti.gov)
  • Because the virus succeeds in multiplying by hijacking cellular processes initiated in response to infection, the scientists searched for drugs that might target these cellular responses, and in so doing stop the virus from reproducing. (infectioncontroltoday.com)
  • Confocal microscopy images reveal the three-dimensional structure of bovine RSV viral RNA in living, infected bovine nasal cells using molecular-scale probes called molecular beacons. (innovations-report.com)
  • Nasal swab viral clearance was rapid. (ersjournals.com)
  • 6 This study included patients typically thought to benefit from anti-MRSA therapy, including individuals admitted to intensive care units, patients with a history of MRSA colonization or infection, or those with a MRSA-positive nasal polymerase chain reaction swab or MRSA found in blood or respiratory cultures within 2 days of admission. (pharmacytimes.com)
  • THURSDAY, April 22, 2021 -- Individuals who have clinically recovered from severe acute respiratory syndrome coronavirus 2 infection and continue to test positive for viral RNA after completing the recommended isolation period do not appear to be infectious to others, according to a study published online April 22 in JAMA Internal Medicine . (drugs.com)
  • It is possible that the virus was cleared by the time of death or that viral copy numbers were below the level of detection by our assays," the researchers note. (medscape.com)