Any vaccine raised against any virus or viral derivative that causes hepatitis.
INFLAMMATION of the LIVER in humans due to infection by VIRUSES. There are several significant types of human viral hepatitis with infection caused by enteric-transmission (HEPATITIS A; HEPATITIS E) or blood transfusion (HEPATITIS B; HEPATITIS C; and HEPATITIS D).
INFLAMMATION of the LIVER in humans caused by a member of the HEPATOVIRUS genus, HUMAN HEPATITIS A VIRUS. It can be transmitted through fecal contamination of food or water.
INFLAMMATION of the LIVER in humans caused by a member of the ORTHOHEPADNAVIRUS genus, HEPATITIS B VIRUS. It is primarily transmitted by parenteral exposure, such as transfusion of contaminated blood or blood products, but can also be transmitted via sexual or intimate personal contact.
INFLAMMATION of the LIVER in humans caused by HEPATITIS C VIRUS, a single-stranded RNA virus. Its incubation period is 30-90 days. Hepatitis C is transmitted primarily by contaminated blood parenterally, and is often associated with transfusion and intravenous drug abuse. However, in a significant number of cases, the source of hepatitis C infection is unknown.
Suspensions of killed or attenuated microorganisms (bacteria, viruses, fungi, protozoa), antigenic proteins, synthetic constructs, or other bio-molecular derivatives, administered for the prevention, amelioration, or treatment of infectious and other diseases.
The type species of the genus ORTHOHEPADNAVIRUS which causes human HEPATITIS B and is also apparently a causal agent in human HEPATOCELLULAR CARCINOMA. The Dane particle is an intact hepatitis virion, named after its discoverer. Non-infectious spherical and tubular particles are also seen in the serum.
INFLAMMATION of the LIVER in humans caused by HEPATITIS B VIRUS lasting six months or more. It is primarily transmitted by parenteral exposure, such as transfusion of contaminated blood or blood products, but can also be transmitted via sexual or intimate personal contact.
Those hepatitis B antigens found on the surface of the Dane particle and on the 20 nm spherical and tubular particles. Several subspecificities of the surface antigen are known. These were formerly called the Australia antigen.
INFLAMMATION of the LIVER in humans that is caused by HEPATITIS C VIRUS lasting six months or more. Chronic hepatitis C can lead to LIVER CIRRHOSIS.
Vaccines or candidate vaccines containing inactivated hepatitis B or some of its component antigens and designed to prevent hepatitis B. Some vaccines may be recombinantly produced.
INFLAMMATION of the LIVER.
INFLAMMATION of the LIVER with ongoing hepatocellular injury for 6 months or more, characterized by NECROSIS of HEPATOCYTES and inflammatory cell (LEUKOCYTES) infiltration. Chronic hepatitis can be caused by viruses, medications, autoimmune diseases, and other unknown factors.
Vaccines or candidate vaccines used to prevent infection with hepatitis A virus (HEPATOVIRUS).
Vaccines in which the infectious microbial nucleic acid components have been destroyed by chemical or physical treatment (e.g., formalin, beta-propiolactone, gamma radiation) without affecting the antigenicity or immunogenicity of the viral coat or bacterial outer membrane proteins.
A species in the genus HEPATOVIRUS containing one serotype and two strains: HUMAN HEPATITIS A VIRUS and Simian hepatitis A virus causing hepatitis in humans (HEPATITIS A) and primates, respectively.
Antibodies to the HEPATITIS B ANTIGENS, including antibodies to the surface (Australia) and core of the Dane particle and those to the "e" antigens.
Antigens of the virion of the HEPATITIS B VIRUS or the Dane particle, its surface (HEPATITIS B SURFACE ANTIGENS), core (HEPATITIS B CORE ANTIGENS), and other associated antigens, including the HEPATITIS B E ANTIGENS.
Suspensions of attenuated or killed viruses administered for the prevention or treatment of infectious viral disease.
Any of the viruses that cause inflammation of the liver. They include both DNA and RNA viruses as well viruses from humans and animals.
Immunoglobulins raised by any form of viral hepatitis; some of these antibodies are used to diagnose the specific kind of hepatitis.
INFLAMMATION of the LIVER in animals due to viral infection.
Small synthetic peptides that mimic surface antigens of pathogens and are immunogenic, or vaccines manufactured with the aid of recombinant DNA techniques. The latter vaccines may also be whole viruses whose nucleic acids have been modified.
Recombinant DNA vectors encoding antigens administered for the prevention or treatment of disease. The host cells take up the DNA, express the antigen, and present it to the immune system in a manner similar to that which would occur during natural infection. This induces humoral and cellular immune responses against the encoded antigens. The vector is called naked DNA because there is no need for complex formulations or delivery agents; the plasmid is injected in saline or other buffers.
Acute INFLAMMATION of the LIVER in humans; caused by HEPATITIS E VIRUS, a non-enveloped single-stranded RNA virus. Similar to HEPATITIS A, its incubation period is 15-60 days and is enterically transmitted, usually by fecal-oral transmission.
Two or more vaccines in a single dosage form.
Antibodies to the HEPATITIS A ANTIGENS including antibodies to envelope, core, and non-structural proteins.
Suspensions of attenuated or killed bacteria administered for the prevention or treatment of infectious bacterial disease.
INFLAMMATION of the LIVER in humans caused by HEPATITIS DELTA VIRUS, a defective RNA virus that can only infect HEPATITIS B patients. For its viral coating, hepatitis delta virus requires the HEPATITIS B SURFACE ANTIGENS produced by these patients. Hepatitis D can occur either concomitantly with (coinfection) or subsequent to (superinfection) hepatitis B infection. Similar to hepatitis B, it is primarily transmitted by parenteral exposure, such as transfusion of contaminated blood or blood products, but can also be transmitted via sexual or intimate personal contact.
A genus of FLAVIVIRIDAE causing parenterally-transmitted HEPATITIS C which is associated with transfusions and drug abuse. Hepatitis C virus is the type species.
A positive-stranded RNA virus species in the genus HEPEVIRUS, causing enterically-transmitted non-A, non-B hepatitis (HEPATITIS E).
Antibodies to the HEPATITIS C ANTIGENS including antibodies to envelope, core, and non-structural proteins.
The hepatitis B antigen within the core of the Dane particle, the infectious hepatitis virion.
A strain of HEPATITIS A VIRUS which causes hepatitis in humans. The virus replicates in hepatocytes and is presumed to reach the intestine via the bile duct. Transmission occurs by the fecal-oral route.
A genus of PICORNAVIRIDAE causing infectious hepatitis naturally in humans and experimentally in other primates. It is transmitted through fecal contamination of food or water. HEPATITIS A VIRUS is the type species.
Liver disease in which the normal microcirculation, the gross vascular anatomy, and the hepatic architecture have been variably destroyed and altered with fibrous septa surrounding regenerated or regenerating parenchymal nodules.
Vaccines or candidate vaccines containing inactivated HIV or some of its component antigens and designed to prevent or treat AIDS. Some vaccines containing antigens are recombinantly produced.
A closely related group of antigens found in the plasma only during the infective phase of hepatitis B or in virulent chronic hepatitis B, probably indicating active virus replication; there are three subtypes which may exist in a complex with immunoglobulins G.
INFLAMMATION of the LIVER in non-human animals.
Administration of vaccines to stimulate the host's immune response. This includes any preparation intended for active immunological prophylaxis.
Vaccines consisting of one or more antigens that stimulate a strong immune response. They are purified from microorganisms or produced by recombinant DNA techniques, or they can be chemically synthesized peptides.
Semisynthetic vaccines consisting of polysaccharide antigens from microorganisms attached to protein carrier molecules. The carrier protein is recognized by macrophages and T-cells thus enhancing immunity. Conjugate vaccines induce antibody formation in people not responsive to polysaccharide alone, induce higher levels of antibody, and show a booster response on repeated injection.
A clinical manifestation of HYPERBILIRUBINEMIA, characterized by the yellowish staining of the SKIN; MUCOUS MEMBRANE; and SCLERA. Clinical jaundice usually is a sign of LIVER dysfunction.
A chronic self-perpetuating hepatocellular INFLAMMATION of unknown cause, usually with HYPERGAMMAGLOBULINEMIA and serum AUTOANTIBODIES.
A defective virus, containing particles of RNA nucleoprotein in virion-like form, present in patients with acute hepatitis B and chronic hepatitis. It requires the presence of a hepadnavirus for full replication. This is the lone species in the genus Deltavirus.
An enzyme that catalyzes the conversion of L-alanine and 2-oxoglutarate to pyruvate and L-glutamate. (From Enzyme Nomenclature, 1992) EC 2.6.1.2.
Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly.
Pathological processes of the LIVER.
A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.
Vaccines made from antigens arising from any of the four strains of Plasmodium which cause malaria in humans, or from P. berghei which causes malaria in rodents.
A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.
Vaccines or candidate vaccines used to prevent PAPILLOMAVIRUS INFECTIONS. Human vaccines are intended to reduce the incidence of UTERINE CERVICAL NEOPLASMS, so they are sometimes considered a type of CANCER VACCINES. They are often composed of CAPSID PROTEINS, especially L1 protein, from various types of ALPHAPAPILLOMAVIRUS.
Tumors or cancer of the LIVER.
Disease having a short and relatively severe course.
A species of the CORONAVIRUS genus causing hepatitis in mice. Four strains have been identified as MHV 1, MHV 2, MHV 3, and MHV 4 (also known as MHV-JHM, which is neurotropic and causes disseminated encephalomyelitis with demyelination as well as focal liver necrosis).
Immunoglobulins produced in response to VIRAL ANTIGENS.
One of the type I interferons produced by peripheral blood leukocytes or lymphoblastoid cells. In addition to antiviral activity, it activates NATURAL KILLER CELLS and B-LYMPHOCYTES, and down-regulates VASCULAR ENDOTHELIAL GROWTH FACTOR expression through PI-3 KINASE and MAPK KINASES signaling pathways.
Blood tests that are used to evaluate how well a patient's liver is working and also to help diagnose liver conditions.
Vaccines or candidate vaccines used to prevent infection with NEISSERIA MENINGITIDIS.
Enzymes of the transferase class that catalyze the conversion of L-aspartate and 2-ketoglutarate to oxaloacetate and L-glutamate. EC 2.6.1.1.
Ribonucleic acid that makes up the genetic material of viruses.
INFLAMMATION of the LIVER due to ALCOHOL ABUSE. It is characterized by NECROSIS of HEPATOCYTES, infiltration by NEUTROPHILS, and deposit of MALLORY BODIES. Depending on its severity, the inflammatory lesion may be reversible or progress to LIVER CIRRHOSIS.
A nucleoside antimetabolite antiviral agent that blocks nucleic acid synthesis and is used against both RNA and DNA viruses.
EPIDEMIOLOGIC STUDIES based on the detection through serological testing of characteristic change in the serum level of specific ANTIBODIES. Latent subclinical infections and carrier states can thus be detected in addition to clinically overt cases.
A live attenuated virus vaccine of chick embryo origin, used for routine immunization of children and for immunization of adolescents and adults who have not had measles or been immunized with live measles vaccine and have no serum antibodies against measles. Children are usually immunized with measles-mumps-rubella combination vaccine. (From Dorland, 28th ed)
Vaccines or candidate vaccines containing antigenic polysaccharides from Haemophilus influenzae and designed to prevent infection. The vaccine can contain the polysaccharides alone or more frequently polysaccharides conjugated to carrier molecules. It is also seen as a combined vaccine with diphtheria-tetanus-pertussis vaccine.
A suspension of formalin-inactivated poliovirus grown in monkey kidney cell tissue culture and used to prevent POLIOMYELITIS.
A suspension of killed Bordetella pertussis organisms, used for immunization against pertussis (WHOOPING COUGH). It is generally used in a mixture with diphtheria and tetanus toxoids (DTP). There is an acellular pertussis vaccine prepared from the purified antigenic components of Bordetella pertussis, which causes fewer adverse reactions than whole-cell vaccine and, like the whole-cell vaccine, is generally used in a mixture with diphtheria and tetanus toxoids. (From Dorland, 28th ed)
An active immunizing agent and a viable avirulent attenuated strain of Mycobacterium tuberculosis, var. bovis, which confers immunity to mycobacterial infections. It is used also in immunotherapy of neoplasms due to its stimulation of antibodies and non-specific immunity.
Vaccines or candidate vaccines used to prevent and treat RABIES. The inactivated virus vaccine is used for preexposure immunization to persons at high risk of exposure, and in conjunction with rabies immunoglobulin, for postexposure prophylaxis.
Vaccines or candidate vaccines used to prevent infection with ROTAVIRUS.
An ORTHOHEPADNAVIRUS causing chronic liver disease and hepatocellular carcinoma in woodchucks. It closely resembles the human hepatitis B virus.
Deoxyribonucleic acid that makes up the genetic material of viruses.
Vaccines or candidate vaccines used to prevent infection with VIBRIO CHOLERAE. The original cholera vaccine consisted of killed bacteria, but other kinds of vaccines now exist.
Antigens of the virions of HEPACIVIRUS, their surface, core, or other associated antigens.
Schedule giving optimum times usually for primary and/or secondary immunization.
A bile pigment that is a degradation product of HEME.
A syndrome characterized by central nervous system dysfunction in association with LIVER FAILURE, including portal-systemic shunts. Clinical features include lethargy and CONFUSION (frequently progressing to COMA); ASTERIXIS; NYSTAGMUS, PATHOLOGIC; brisk oculovestibular reflexes; decorticate and decerebrate posturing; MUSCLE SPASTICITY; and bilateral extensor plantar reflexes (see REFLEX, BABINSKI). ELECTROENCEPHALOGRAPHY may demonstrate triphasic waves. (From Adams et al., Principles of Neurology, 6th ed, pp1117-20; Plum & Posner, Diagnosis of Stupor and Coma, 3rd ed, p222-5)
The total number of cases of a given disease in a specified population at a designated time. It is differentiated from INCIDENCE, which refers to the number of new cases in the population at a given time.
INFLAMMATION of the LIVER in humans caused by HEPATITIS DELTA VIRUS in conjunction with HEPATITIS B VIRUS and lasting six months or more.
A genus of Sciuridae consisting of 14 species. They are shortlegged, burrowing rodents which hibernate in winter.
A form of rapid-onset LIVER FAILURE, also known as fulminant hepatic failure, caused by severe liver injury or massive loss of HEPATOCYTES. It is characterized by sudden development of liver dysfunction and JAUNDICE. Acute liver failure may progress to exhibit cerebral dysfunction even HEPATIC COMA depending on the etiology that includes hepatic ISCHEMIA, drug toxicity, malignant infiltration, and viral hepatitis such as post-transfusion HEPATITIS B and HEPATITIS C.
Vaccines used to prevent TYPHOID FEVER and/or PARATYPHOID FEVER which are caused by various species of SALMONELLA. Attenuated, subunit, and inactivated forms of the vaccines exist.
A vaccine consisting of DIPHTHERIA TOXOID; TETANUS TOXOID; and whole-cell PERTUSSIS VACCINE. The vaccine protects against diphtheria, tetanus, and whooping cough.
A live VACCINIA VIRUS vaccine of calf lymph or chick embryo origin, used for immunization against smallpox. It is now recommended only for laboratory workers exposed to smallpox virus. Certain countries continue to vaccinate those in the military service. Complications that result from smallpox vaccination include vaccinia, secondary bacterial infections, and encephalomyelitis. (Dorland, 28th ed)
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Any immunization following a primary immunization and involving exposure to the same or a closely related antigen.
A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, and chemicals from the environment.
Vaccines or candidate vaccines used to prevent or treat TUBERCULOSIS.
A live, attenuated varicella virus vaccine used for immunization against chickenpox. It is recommended for children between the ages of 12 months and 13 years.
The transference of a part of or an entire liver from one human or animal to another.
Includes the spectrum of human immunodeficiency virus infections that range from asymptomatic seropositivity, thru AIDS-related complex (ARC), to acquired immunodeficiency syndrome (AIDS).
Substances that augment, stimulate, activate, potentiate, or modulate the immune response at either the cellular or humoral level. The classical agents (Freund's adjuvant, BCG, Corynebacterium parvum, et al.) contain bacterial antigens. Some are endogenous (e.g., histamine, interferon, transfer factor, tuftsin, interleukin-1). Their mode of action is either non-specific, resulting in increased immune responsiveness to a wide variety of antigens, or antigen-specific, i.e., affecting a restricted type of immune response to a narrow group of antigens. The therapeutic efficacy of many biological response modifiers is related to their antigen-specific immunoadjuvanticity.
Vaccines used to prevent infection by MUMPS VIRUS. Best known is the live attenuated virus vaccine of chick embryo origin, used for routine immunization of children and for immunization of adolescents and adults who have not had mumps or been immunized with live mumps vaccine. Children are usually immunized with measles-mumps-rubella combination vaccine.
Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care. (Dictionary of Health Services Management, 2d ed)
Antigens produced by various strains of HEPATITIS A VIRUS such as the human hepatitis A virus (HEPATITIS A VIRUS, HUMAN).
The process of intracellular viral multiplication, consisting of the synthesis of PROTEINS; NUCLEIC ACIDS; and sometimes LIPIDS, and their assembly into a new infectious particle.
Antigens from any of the hepatitis viruses including surface, core, and other associated antigens.
Antigens produced by various strains of HEPATITIS D VIRUS.
The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B.
A combined vaccine used to prevent MEASLES; MUMPS; and RUBELLA.
The condition of harboring an infective organism without manifesting symptoms of infection. The organism must be readily transmissible to another susceptible host.
An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.
The main structural component of the LIVER. They are specialized EPITHELIAL CELLS that are organized into interconnected plates called lobules.
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
A country in northern Africa, bordering the Mediterranean Sea, between Libya and the Gaza Strip, and the Red Sea north of Sudan, and includes the Asian Sinai Peninsula Its capital is Cairo.
Deliberate stimulation of the host's immune response. ACTIVE IMMUNIZATION involves administration of ANTIGENS or IMMUNOLOGIC ADJUVANTS. PASSIVE IMMUNIZATION involves administration of IMMUNE SERA or LYMPHOCYTES or their extracts (e.g., transfer factor, immune RNA) or transplantation of immunocompetent cell producing tissue (thymus or bone marrow).
A DNA virus that closely resembles human hepatitis B virus. It has been recovered from naturally infected ducks.
Vaccines or candidate vaccines used to prevent STREPTOCOCCAL INFECTIONS.
A reverse transcriptase inhibitor and ZALCITABINE analog in which a sulfur atom replaces the 3' carbon of the pentose ring. It is used to treat HIV disease.
Proteins encoded by a VIRAL GENOME that are produced in the organisms they infect, but not packaged into the VIRUS PARTICLES. Some of these proteins may play roles within the infected cell during VIRUS REPLICATION or act in regulation of virus replication or VIRUS ASSEMBLY.
The quantity of measurable virus in a body fluid. Change in viral load, measured in plasma, is sometimes used as a SURROGATE MARKER in disease progression.
Vaccines or candidate vaccines used to prevent ANTHRAX.
FIBROSIS of the hepatic parenchyma due to chronic excess ALCOHOL DRINKING.
'Blood donors' are individuals who voluntarily and safely donate a specific amount of their own blood, which can be further separated into components, to be used for transfusion purposes or for manufacturing medical products, without receiving remuneration that is intended to reward them financially.
Vaccines using VIROSOMES as the antigen delivery system that stimulates the desired immune response.
Vaccines or candidate vaccines used to prevent infection with DENGUE VIRUS. These include live-attenuated, subunit, DNA, and inactivated vaccines.
The genetic constitution of the individual, comprising the ALLELES present at each GENETIC LOCUS.
Proteins prepared by recombinant DNA technology.
Polymers of ETHYLENE OXIDE and water, and their ethers. They vary in consistency from liquid to solid depending on the molecular weight indicated by a number following the name. They are used as SURFACTANTS, dispersing agents, solvents, ointment and suppository bases, vehicles, and tablet excipients. Some specific groups are NONOXYNOLS, OCTOXYNOLS, and POLOXAMERS.
Severe inability of the LIVER to perform its normal metabolic functions, as evidenced by severe JAUNDICE and abnormal serum levels of AMMONIA; BILIRUBIN; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; LACTATE DEHYDROGENASES; and albumin/globulin ratio. (Blakiston's Gould Medical Dictionary, 4th ed)
The common chimpanzee, a species of the genus Pan, family HOMINIDAE. It lives in Africa, primarily in the tropical rainforests. There are a number of recognized subspecies.
Inbred BALB/c mice are a strain of laboratory mice that have been selectively bred to be genetically identical to each other, making them useful for scientific research and experiments due to their consistent genetic background and predictable responses to various stimuli or treatments.
Immunoglobulins produced in a response to BACTERIAL ANTIGENS.
A live vaccine containing attenuated poliovirus, types I, II, and III, grown in monkey kidney cell tissue culture, used for routine immunization of children against polio. This vaccine induces long-lasting intestinal and humoral immunity. Killed vaccine induces only humoral immunity. Oral poliovirus vaccine should not be administered to immunocompromised individuals or their household contacts. (Dorland, 28th ed)
A class of immunoglobulin bearing mu chains (IMMUNOGLOBULIN MU-CHAINS). IgM can fix COMPLEMENT. The name comes from its high molecular weight and originally being called a macroglobulin.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
Vaccine used to prevent YELLOW FEVER. It consists of a live attenuated 17D strain of the YELLOW FEVER VIRUS.
Diagnostic procedures involving immunoglobulin reactions.
Elements of limited time intervals, contributing to particular results or situations.
Organized services to administer immunization procedures in the prevention of various diseases. The programs are made available over a wide range of sites: schools, hospitals, public health agencies, voluntary health agencies, etc. They are administered to an equally wide range of population groups or on various administrative levels: community, municipal, state, national, international.
A suspension of killed Yersinia pestis used for immunizing people in enzootic plague areas.
The number of new cases of a given disease during a given period in a specified population. It also is used for the rate at which new events occur in a defined population. It is differentiated from PREVALENCE, which refers to all cases, new or old, in the population at a given time.
West Germany refers to the Federal Republic of Germany (FRG), which was the democratic and economically prosperous part of Germany that existed from 1949 to 1990, consisting of the states in the American, British, and French zones of occupation after World War II, and reunified with East Germany in 1990 to form a unified Federal Republic of Germany.
Suspensions of attenuated or killed fungi administered for the prevention or treatment of infectious fungal disease.
I'm sorry for any confusion, but "India" is not a medical term that can be defined in a medical context. It is a geographical location, referring to the Republic of India, a country in South Asia. If you have any questions related to medical topics or definitions, I would be happy to help with those!
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
Vaccines using supra-molecular structures composed of multiple copies of recombinantly expressed viral structural proteins. They are often antigentically indistinguishable from the virus from which they were derived.
Removal and pathologic examination of specimens in the form of small pieces of tissue from the living body.
Lipid infiltration of the hepatic parenchymal cells resulting in a yellow-colored liver. The abnormal lipid accumulation is usually in the form of TRIGLYCERIDES, either as a single large droplet or multiple small droplets. Fatty liver is caused by an imbalance in the metabolism of FATTY ACIDS.
A live attenuated virus vaccine of duck embryo or human diploid cell tissue culture origin, used for routine immunization of children and for immunization of nonpregnant adolescent and adult females of childbearing age who are unimmunized and do not have serum antibodies to rubella. Children are usually immunized with measles-mumps-rubella combination vaccine. (Dorland, 28th ed)
Ongoing scrutiny of a population (general population, study population, target population, etc.), generally using methods distinguished by their practicability, uniformity, and frequently their rapidity, rather than by complete accuracy.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
Proteins found mainly in icosahedral DNA and RNA viruses. They consist of proteins directly associated with the nucleic acid inside the NUCLEOCAPSID.
Vaccines that are produced by using only the antigenic part of the disease causing organism. They often require a "booster" every few years to maintain their effectiveness.
Substances elaborated by viruses that have antigenic activity.
Sudden increase in the incidence of a disease. The concept includes EPIDEMICS and PANDEMICS.
The term "United States" in a medical context often refers to the country where a patient or study participant resides, and is not a medical term per se, but relevant for epidemiological studies, healthcare policies, and understanding differences in disease prevalence, treatment patterns, and health outcomes across various geographic locations.
Antibodies that reduce or abolish some biological activity of a soluble antigen or infectious agent, usually a virus.
Vaccines or candidate vaccines designed to prevent SAIDS; (SIMIAN ACQUIRED IMMUNODEFICIENCY SYNDROME); and containing inactivated SIMIAN IMMUNODEFICIENCY VIRUS or type D retroviruses or some of their component antigens.
Vaccines or candidate vaccines used to prevent infection with SALMONELLA. This includes vaccines used to prevent TYPHOID FEVER or PARATYPHOID FEVER; (TYPHOID-PARATYPHOID VACCINES), and vaccines used to prevent nontyphoid salmonellosis.
In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.
Forceful administration into a muscle of liquid medication, nutrient, or other fluid through a hollow needle piercing the muscle and any tissue covering it.
Vaccines or candidate vaccines used to prevent EBOLA HEMORRHAGIC FEVER.
The practice of medicine as applied to special circumstances associated with military operations.
An acute viral infection in humans involving the respiratory tract. It is marked by inflammation of the NASAL MUCOSA; the PHARYNX; and conjunctiva, and by headache and severe, often generalized, myalgia.
Liver diseases associated with ALCOHOLISM. It usually refers to the coexistence of two or more subentities, i.e., ALCOHOLIC FATTY LIVER; ALCOHOLIC HEPATITIS; and ALCOHOLIC CIRRHOSIS.
Therapy with two or more separate preparations given for a combined effect.
Combined vaccines consisting of DIPHTHERIA TOXOID; TETANUS TOXOID; and an acellular form of PERTUSSIS VACCINE. At least five different purified antigens of B. pertussis have been used in various combinations in these vaccines.
Established cell cultures that have the potential to propagate indefinitely.
Layers of protein which surround the capsid in animal viruses with tubular nucleocapsids. The envelope consists of an inner layer of lipids and virus specified proteins also called membrane or matrix proteins. The outer layer consists of one or more types of morphological subunits called peplomers which project from the viral envelope; this layer always consists of glycoproteins.
Proteins secreted by vertebrate cells in response to a wide variety of inducers. They confer resistance against many different viruses, inhibit proliferation of normal and malignant cells, impede multiplication of intracellular parasites, enhance macrophage and granulocyte phagocytosis, augment natural killer cell activity, and show several other immunomodulatory functions.
The complete genetic complement contained in a DNA or RNA molecule in a virus.

Protective immunity against murine hepatitis virus (MHV) induced by intranasal or subcutaneous administration of hybrids of tobacco mosaic virus that carries an MHV epitope. (1/271)

Hybrids of tobacco mosaic virus (TMV) were constructed with the use of fusion to the coat protein peptides of 10 or 15 amino acids, containing the 5B19 epitope from the spike protein of murine hepatitis virus (MHV) and giving rise to TMV-5B19 and TMV-5B19L, respectively. The TMV hybrids were propagated in tobacco plants, and the virus particles were purified. Immunogold labeling, with the use of the monoclonal MAb5B19 antibody, showed specific decoration of hybrid TMV particles, confirming the expression and display of the MHV epitope on the surface of the TMV. Mice were immunized with purified hybrid viruses after several regimens of immunization. Mice that received TMV-5B19L intranasally developed serum IgG and IgA specific for the 5B19 epitope and for the TMV coat protein. Hybrid TMV-5B19, administered by subcutaneous injections, elicited high titers of serum IgG that was specific for the 5B19 epitope and for coat protein, but IgA that was specific against 5B19 was not observed. Mice that were immunized with hybrid virus by subcutaneous or intranasal routes of administration survived challenge with a lethal dose (10 x LD50) of MHV strain JHM, whereas mice administered wild-type TMV died 10 d post challenge. Furthermore, there was a positive correlation between the dose of administered immunogen and protection against MHV infection. These studies show that TMV can be an effective vaccine delivery vehicle for parenteral and mucosal immunization and for protection from challenge with viral infection.  (+info)

Expression of noncovalent hepatitis C virus envelope E1-E2 complexes is not required for the induction of antibodies with neutralizing properties following DNA immunization. (2/271)

Interactive glycoproteins present on the surface of viral particles represent the main target of neutralizing antibodies. The ability of DNA vaccination to induce antibodies directed at such structures was investigated by using eight different expression plasmids engineered either to favor or to prevent interaction between the hepatitis C virus (HCV) envelope glycoproteins E1 and E2. Independently of the injection route (intramuscular or intraepidermal), plasmids expressing antigens capable of forming heterodimers presumed to be the prebudding form of the HCV envelope protein complex failed to induce any significant, stable antibodies following injection in mice. In sharp contrast, high titers of antibodies directed at both conformational and linear determinants were induced by using plasmids expressing severely truncated antigens that have lost the ability to form native complexes. In addition, only a truncated form of E2 induced antibodies reacting against the hypervariable region 1 of E2 (specifically with the C-terminal part of it) known to contain a neutralization site. When injected intraepidermally into small primates, the truncated E2-encoding plasmid induced antibodies able to neutralize in vitro the binding of a purified E2 protein onto susceptible cells. Because such antibodies have been associated with viral clearance in both humans and chimpanzees, these findings may have important implications for the development of protective immunity against HCV.  (+info)

Prevention of hepatitis A through active or passive immunization: Recommendations of the Advisory Committee on Immunization Practices (ACIP). (3/271)

Routine vaccination of children is the most effective way to reduce hepatitis A incidence nationwide over time. Since licensure of hepatitis A vaccine in 1995, this strategy has been implemented incrementally, starting with the recommendation of the Advisory Committee on Immunization Practices (ACIP) in 1996 to vaccinate children living in communities with the highest rates of infection and disease. These updated recommendations represent the next phase of this hepatitis A immunization strategy. Vaccination of children living in states and communities with consistently elevated rates of hepatitis A will provide protection from disease and is expected to reduce the overall incidence of hepatitis A. This report updates the ACIP's 1996 recommendations on the prevention of hepatitis A through immunization (MMWR 1996;45:[No. RR-151) and includes a) new data about the epidemiology of hepatitis A; b) recent findings about the effectiveness of community-based hepatitis A vaccination programs; and c) recommendations for the routine vaccination of children in states, counties, and communities with rates that are twice the 1987-1997 national average or greater (i.e., > or = 20 cases per 100,000 population) and consideration of routine vaccination of children in states, counties, and communities with rates exceeding the 1987-1997 national average (i.e., > or = 10 but <20 cases per 100,000 population). Unchanged in this report are previous recommendations regarding the vaccination of persons in groups at increased risk for hepatitis A or its adverse consequences and recommendations regarding the use of immune globulin for protection against hepatitis A.  (+info)

Immunogenicity and safety of hepatitis A vaccine in liver and renal transplant recipients. (4/271)

Organ transplant recipients with chronic hepatitis B or hepatitis C virus infection may be at increased risk of fulminant hepatitis A. Liver transplant (LTX) recipients, renal transplant (RTX) recipients, and healthy controls received 2 doses of hepatitis A vaccine 6 months apart. Anti-hepatitis A virus (anti-HAV) seroconversion after the primary dose occurred in 41% of the LTX patients, 24% of the RTX patients, and 90% of the controls. After the booster dose, the respective rates were 97%, 72%, and 100% (P<.001). RTX patients also had significantly lower geometric mean titers (GMTs) of anti-HAV than LTX patients and controls. In the RTX group, the seroconversion rate and GMT were inversely associated with the number of immunosuppressive drugs received by the patients. The vaccine was well tolerated. Hepatitis A vaccine can be recommended to LTX and RTX patients, but the patients should receive a full course of 2 doses before imminent exposure.  (+info)

Interference of antibody production to hepatitis B surface antigen in a combination hepatitis A/hepatitis B vaccine. (5/271)

A randomized trial comparing 3 manufacturing consistency lots of a combination hepatitis A/hepatitis B vaccine to each other and to hepatitis A vaccine and hepatitis B vaccine given separately and concurrently was done to evaluate safety, tolerability, and immunogenicity. Healthy volunteers >/=11 years of age were divided into 4 groups. Each of 3 groups received a separate consistency lot of the combination vaccine, and 1 group received separate but concurrent injections of hepatitis A and hepatitis B vaccines. Injections were given at weeks 0 and 24. The combination vaccine was generally well tolerated. The hepatitis A portion of the combination vaccine produced clinically acceptable high seropositivity rates 4 and 52 weeks after the first injection. The hepatitis B portion of the vaccine did not produce clinically acceptable seropositivity rates 4 weeks after the second injection. Lack of antibody production may be attributed, at least in part, to immunologic interference.  (+info)

Inactivated hepatitis A vaccine in Chinese patients with chronic hepatitis B infection. (6/271)

BACKGROUND: Hepatitis B (HBV)-infected patients have a higher morbidity and mortality when super-infected by hepatitis A (HAV). AIM: To evaluate the immunogenicity and safety of a commercial inactivated HAV vaccine in Chinese patients with chronic HBV infection. METHODS: Sixty-five HBV-infected patients (30 carriers, 22 chronic hepatitis, 13 cirrhosis), who were seronegative for HAV, received a dose of 1440 ELISA units of HAV vaccine at weeks 0 and 24. Twenty-eight healthy individuals aged 18-57 years, who were seronegative for both HBV and HAV infection, also received the same vaccination regimen. Seroconversion was defined as an anti-HAV titre >/= 33 mIU/mL. RESULTS: The seroconversion rates for the HBV-infected patients at weeks 2, 4 and 24 were 72, 91 and 80%, respectively. The corresponding geometric mean titres (GMTs) were 103, 311 and 123 mIU/mL. In the healthy control group the seroconversion rates were 86, 93 and 89% at weeks 2, 4 and 24. The corresponding GMTs were 112, 158 and 250 mIU/mL. There was no difference in the seroconversion rates between the two groups, but healthy controls had a significantly higher GMT at week 24 (P=0.04). Side-effects were more common in HBV patients. CONCLUSION: The HAV vaccine is equally efficacious in patients with chronic HBV infection.  (+info)

Immune responses to hepatitis C virus structural and nonstructural proteins induced by plasmid DNA immunizations. (7/271)

DNA-based immunizations have been used to elicit cellular immunity to hepatitis C virus (HCV) proteins in mice. Mice were immunized by intramuscular or intradermal injections of plasmid DNA derived from a near-full-length HCV genotype 1b genomic clone (pRC/B2) or individual genomic clones. These immunizations induced cytotoxic T lymphocytes (CTLs), as revealed in standard chromium-release assays that used syngeneic peptide-pulsed or transfected target cells. These assays identified four CTL epitopes within the capsid, E1, and E2 regions of the polyprotein sequence of HCV genotype 1a that were cross-reactive with HCV genotype 1b. Additionally, CTLs derived from mice immunized with either NS3 or NS5 specifically lysed target cells sensitized to either the genotype 1a or 1b gene products. Nucleic acid immunizations also generated humoral immunity to HCV proteins, as detected by anti-HCV reactivity to NS3 and capsid in ELISAs and immunoblot assays.  (+info)

Prevalence of hepatitis B, D and C virus infections among children and pregnant women in Moldova: additional evidence supporting the need for routine hepatitis B vaccination of infants. (8/271)

Rates of acute hepatitis B are high in Moldova, but the prevalence of chronic infection is unknown. In 1994, we surveyed children and pregnant women, collected demographic information, and drew blood for laboratory testing. Among the 439 children (mean age, 5 years), the prevalence of antibody to hepatitis B core antigen (anti-HBc) and hepatitis B surface antigen (HBsAg) were 17.1 and 6.8%, respectively. Among the 1098 pregnant women (mean age, 26 years), 52.4% were anti-HBc-positive and 9.7% were HBsAg-positive. Of the HBsAg-positive pregnant women, 35.6% were hepatitis B e antigen (HBeAg) positive and 18.3% had antibodies to hepatitis D virus. The prevalence of antibody to hepatitis C virus was 1.4% in children and 2.3% in pregnant women. The high HBeAg prevalence among HBsAg-positive pregnant women and the high anti-HBc prevalence among children indicate that both perinatal and early childhood transmission contribute to the high hepatitis B virus endemicity in Moldova.  (+info)

Viral hepatitis vaccines are vaccines that prevent infection caused by various hepatitis viruses, including hepatitis A and B. These vaccines contain antigens that stimulate the immune system to produce antibodies that protect against infection with the corresponding virus. The vaccines are typically administered through injection and may require multiple doses for full protection.

The hepatitis A vaccine is made from inactivated hepatitis A virus, while the hepatitis B vaccine is made from recombinant hepatitis B surface antigen. Both vaccines have been shown to be highly effective in preventing infection and reducing the risk of complications associated with viral hepatitis, such as liver disease and liver cancer.

It's important to note that there are no vaccines available for other types of viral hepatitis, such as hepatitis C, D, or E. Prevention strategies for these types of viral hepatitis typically involve measures to reduce exposure to the virus, such as safe injection practices and avoiding high-risk behaviors like sharing needles or having unprotected sex with infected individuals.

Viral hepatitis in humans refers to inflammation of the liver caused by infection with viruses that primarily target the liver. There are five main types of human viral hepatitis, designated as Hepatitis A, B, C, D, and E virus (HAV, HBV, HCV, HDV, and HEV). These viruses can cause a range of illnesses, from acute self-limiting hepatitis to chronic hepatitis, which can lead to cirrhosis and liver cancer.

1. Hepatitis A virus (HAV) is typically spread through the fecal-oral route, often through contaminated food or water. It usually results in an acute self-limiting infection, but rarely can cause chronic hepatitis in individuals with weakened immune systems.
2. Hepatitis B virus (HBV) is primarily transmitted through contact with infected blood, semen, and other bodily fluids. It can lead to both acute and chronic hepatitis, which may result in cirrhosis and liver cancer if left untreated.
3. Hepatitis C virus (HCV) is predominantly spread through exposure to infected blood, such as through sharing needles or receiving contaminated blood transfusions. Chronic hepatitis C is common, and it can lead to serious liver complications like cirrhosis and liver cancer if not treated.
4. Hepatitis D virus (HDV) is an incomplete virus that requires the presence of HBV for its replication. HDV infection occurs only in individuals already infected with HBV, leading to more severe liver disease compared to HBV monoinfection.
5. Hepatitis E virus (HEV) is primarily transmitted through the fecal-oral route, often through contaminated food or water. It usually results in an acute self-limiting infection but can cause chronic hepatitis in pregnant women and individuals with weakened immune systems.

Prevention measures include vaccination for HAV and HBV, safe sex practices, avoiding sharing needles, and ensuring proper hygiene and sanitation to prevent fecal-oral transmission.

Hepatitis A is a viral infection that specifically targets the liver, causing inflammation and impaired function. This disease is caused by the hepatitis A virus (HAV), which spreads primarily through the fecal-oral route, often due to poor sanitation and hygiene. Individuals can become infected by consuming food or water contaminated with HAV or by coming into direct contact with an infected person's stool.

The symptoms of hepatitis A may include fatigue, loss of appetite, nausea, vomiting, abdominal pain, dark urine, clay-colored bowel movements, joint pain, and jaundice (yellowing of the skin and eyes). However, in some cases, particularly in children under six years old, the infection may be asymptomatic.

While hepatitis A can be unpleasant and cause serious complications, it is rarely fatal and most people recover completely within a few months. Preventive measures include vaccination, practicing good hygiene, and avoiding potentially contaminated food and water.

Hepatitis B is a viral infection that attacks the liver and can cause both acute and chronic disease. The virus is transmitted through contact with infected blood, semen, and other bodily fluids. It can also be passed from an infected mother to her baby at birth.

Acute hepatitis B infection lasts for a few weeks to several months and often causes no symptoms. However, some people may experience mild to severe flu-like symptoms, yellowing of the skin and eyes (jaundice), dark urine, and fatigue. Most adults with acute hepatitis B recover completely and develop lifelong immunity to the virus.

Chronic hepatitis B infection can lead to serious liver damage, including cirrhosis and liver cancer. People with chronic hepatitis B may experience long-term symptoms such as fatigue, joint pain, and depression. They are also at risk for developing liver failure and liver cancer.

Prevention measures include vaccination, safe sex practices, avoiding sharing needles or other drug injection equipment, and covering wounds and skin rashes. There is no specific treatment for acute hepatitis B, but chronic hepatitis B can be treated with antiviral medications to slow the progression of liver damage.

Hepatitis C is a liver infection caused by the hepatitis C virus (HCV). It's primarily spread through contact with contaminated blood, often through sharing needles or other equipment to inject drugs. For some people, hepatitis C is a short-term illness but for most — about 75-85% — it becomes a long-term, chronic infection that can lead to serious health problems like liver damage, liver failure, and even liver cancer. The virus can infect and inflame the liver, causing symptoms like jaundice (yellowing of the skin and eyes), abdominal pain, fatigue, and dark urine. Many people with hepatitis C don't have any symptoms, so they might not know they have the infection until they experience complications. There are effective treatments available for hepatitis C, including antiviral medications that can cure the infection in most people. Regular testing is important to diagnose and treat hepatitis C early, before it causes serious health problems.

A vaccine is a biological preparation that provides active acquired immunity to a particular infectious disease. It typically contains an agent that resembles the disease-causing microorganism and is often made from weakened or killed forms of the microbe, its toxins, or one of its surface proteins. The agent stimulates the body's immune system to recognize the agent as a threat, destroy it, and "remember" it, so that the immune system can more easily recognize and destroy any of these microorganisms that it encounters in the future.

Vaccines can be prophylactic (to prevent or ameliorate the effects of a future infection by a natural or "wild" pathogen), or therapeutic (to fight disease that is already present). The administration of vaccines is called vaccination. Vaccinations are generally administered through needle injections, but can also be administered by mouth or sprayed into the nose.

The term "vaccine" comes from Edward Jenner's 1796 use of cowpox to create immunity to smallpox. The first successful vaccine was developed in 1796 by Edward Jenner, who showed that milkmaids who had contracted cowpox did not get smallpox. He reasoned that exposure to cowpox protected against smallpox and tested his theory by injecting a boy with pus from a cowpox sore and then exposing him to smallpox, which the boy did not contract. The word "vaccine" is derived from Variolae vaccinae (smallpox of the cow), the term devised by Jenner to denote cowpox. He used it in 1798 during a conversation with a fellow physician and later in the title of his 1801 Inquiry.

Hepatitis B virus (HBV) is a DNA virus that belongs to the Hepadnaviridae family and causes the infectious disease known as hepatitis B. This virus primarily targets the liver, where it can lead to inflammation and damage of the liver tissue. The infection can range from acute to chronic, with chronic hepatitis B increasing the risk of developing serious liver complications such as cirrhosis and liver cancer.

The Hepatitis B virus has a complex life cycle, involving both nuclear and cytoplasmic phases. It enters hepatocytes (liver cells) via binding to specific receptors and is taken up by endocytosis. The viral DNA is released into the nucleus, where it is converted into a covalently closed circular DNA (cccDNA) form, which serves as the template for viral transcription.

HBV transcribes several RNAs, including pregenomic RNA (pgRNA), which is used as a template for reverse transcription during virion assembly. The pgRNA is encapsidated into core particles along with the viral polymerase and undergoes reverse transcription to generate new viral DNA. This process occurs within the cytoplasm of the hepatocyte, resulting in the formation of immature virions containing partially double-stranded DNA.

These immature virions are then enveloped by host cell membranes containing HBV envelope proteins (known as surface antigens) to form mature virions that can be secreted from the hepatocyte and infect other cells. The virus can also integrate into the host genome, which may contribute to the development of hepatocellular carcinoma in chronic cases.

Hepatitis B is primarily transmitted through exposure to infected blood or bodily fluids containing the virus, such as through sexual contact, sharing needles, or from mother to child during childbirth. Prevention strategies include vaccination, safe sex practices, and avoiding needle-sharing behaviors. Treatment for hepatitis B typically involves antiviral medications that can help suppress viral replication and reduce the risk of liver damage.

Chronic Hepatitis B is a persistent infection of the liver caused by the hepatitis B virus (HBV), which can lead to chronic inflammation and scarring of the liver over time. It is defined as the presence of hepatitis B surface antigen (HBsAg) in the blood for more than six months.

The infection can be asymptomatic or may cause nonspecific symptoms such as fatigue, loss of appetite, nausea, and joint pain. A small percentage of people with chronic HBV infection may develop serious complications, including cirrhosis, liver failure, and liver cancer. Treatment options for chronic hepatitis B include antiviral medications that can help to suppress the virus and reduce the risk of liver damage. Vaccination is available to prevent hepatitis B infection.

Hepatitis B Surface Antigens (HBsAg) are proteins found on the surface of the Hepatitis B virus. They are present in the blood of individuals infected with the Hepatitis B virus and are used as a marker for the presence of a current Hepatitis B infection. The detection of HBsAg in the blood indicates that an individual is infectious and can transmit the virus to others. It is typically used in diagnostic tests to detect and diagnose Hepatitis B infections, monitor treatment response, and assess the risk of transmission.

Chronic Hepatitis C is a liver infection caused by the hepatitis C virus (HCV) that lasts for more than six months. This long-term infection can lead to scarring of the liver (cirrhosis), which can cause serious health problems, such as liver failure or liver cancer, in some individuals. The infection is usually asymptomatic until complications arise, but it can be detected through blood tests that identify antibodies to the virus or viral RNA. Chronic hepatitis C is typically managed with antiviral therapy, which can help clear the virus from the body and reduce the risk of liver damage.

"Hepatitis B vaccines are vaccines that prevent infection caused by the hepatitis B virus. They work by introducing a small and harmless piece of the virus to your body, which triggers your immune system to produce antibodies to fight off the infection. These antibodies remain in your body and provide protection if you are exposed to the real hepatitis B virus in the future.

The hepatitis B vaccine is typically given as a series of three shots over a six-month period. It is recommended for all infants, children and adolescents who have not previously been vaccinated, as well as for adults who are at increased risk of infection, such as healthcare workers, people who inject drugs, and those with certain medical conditions.

It's important to note that hepatitis B vaccine does not provide protection against other types of viral hepatitis, such as hepatitis A or C."

Hepatitis is a medical condition characterized by inflammation of the liver, often resulting in damage to liver cells. It can be caused by various factors, including viral infections (such as Hepatitis A, B, C, D, and E), alcohol abuse, toxins, medications, and autoimmune disorders. Symptoms may include jaundice, fatigue, abdominal pain, loss of appetite, nausea, vomiting, and dark urine. The severity of the disease can range from mild illness to severe, life-threatening conditions, such as liver failure or cirrhosis.

Chronic hepatitis is a type of liver inflammation that lasts for more than six months and can lead to scarring of the liver (cirrhosis), liver failure, and even liver cancer in some cases. It can be caused by various factors, including viral infections such as Hepatitis B and C, autoimmune disorders, alcohol abuse, and non-alcoholic fatty liver disease. The symptoms of chronic hepatitis may include fatigue, loss of appetite, nausea, vomiting, abdominal pain, joint pain, dark urine, and jaundice (yellowing of the skin and eyes). Treatment for chronic hepatitis depends on the underlying cause and may include antiviral medications, immunosuppressive drugs, or lifestyle changes.

Hepatitis A vaccines are inactivated or live attenuated viral vaccines that are administered to prevent infection and illness caused by the hepatitis A virus. The vaccine contains antigens that stimulate an immune response in the body, leading to the production of antibodies that protect against future infection with the virus.

The inactivated hepatitis A vaccine is made from viruses that have been chemically treated to destroy their ability to cause disease while preserving their ability to stimulate an immune response. This type of vaccine is typically given in two doses, six months apart, and provides long-term protection against the virus.

The live attenuated hepatitis A vaccine contains a weakened form of the virus that is unable to cause illness but can still stimulate an immune response. This type of vaccine is given as a single dose and provides protection against the virus for at least 20 years.

Hepatitis A vaccines are recommended for people who are at increased risk of infection, including travelers to areas where hepatitis A is common, men who have sex with men, people who use injection drugs, and people with chronic liver disease or clotting factor disorders. The vaccine is also recommended for children in certain states and communities where hepatitis A is endemic.

Inactivated vaccines, also known as killed or non-live vaccines, are created by using a version of the virus or bacteria that has been grown in a laboratory and then killed or inactivated with chemicals, heat, or radiation. This process renders the organism unable to cause disease, but still capable of stimulating an immune response when introduced into the body.

Inactivated vaccines are generally considered safer than live attenuated vaccines since they cannot revert back to a virulent form and cause illness. However, they may require multiple doses or booster shots to maintain immunity because the immune response generated by inactivated vaccines is not as robust as that produced by live vaccines. Examples of inactivated vaccines include those for hepatitis A, rabies, and influenza (inactivated flu vaccine).

Hepatitis A virus (HAV) is the causative agent of hepatitis A, a viral infection that causes inflammation of the liver. It is a small, non-enveloped, single-stranded RNA virus belonging to the Picornaviridae family and Hepatovirus genus. The virus primarily spreads through the fecal-oral route, often through contaminated food or water, or close contact with an infected person. After entering the body, HAV infects hepatocytes in the liver, leading to liver damage and associated symptoms such as jaundice, fatigue, abdominal pain, and nausea. The immune system eventually clears the infection, providing lifelong immunity against future HAV infections. Preventive measures include vaccination and practicing good hygiene to prevent transmission.

Hepatitis B antibodies are proteins produced by the immune system in response to the presence of the Hepatitis B virus. There are two main types of Hepatitis B antibodies:

1. Hepatitis B surface antibody (anti-HBs): This is produced when a person has recovered from a Hepatitis B infection or has been successfully vaccinated against the virus. The presence of anti-HBs indicates immunity to Hepatitis B.
2. Hepatitis B core antibody (anti-HBC): This is produced during a Hepatitis B infection and remains present for life, even after the infection has been cleared. However, the presence of anti-HBC alone does not indicate immunity to Hepatitis B, as it can also be present in people who have a chronic Hepatitis B infection.

It's important to note that testing for Hepatitis B antibodies is typically done through blood tests and can help determine whether a person has been infected with the virus, has recovered from an infection, or has been vaccinated against it.

Hepatitis B antigens are proteins or particles present on the surface (HBsAg) or inside (HBcAg, HBeAg) the hepatitis B virus.

1. HBsAg (Hepatitis B surface antigen): This is a protein found on the outer surface of the hepatitis B virus. Its presence in the blood indicates an active infection with hepatitis B virus. It's also used as a marker to diagnose hepatitis B infection and monitor treatment response.

2. HBcAg (Hepatitis B core antigen): This is a protein found inside the hepatitis B virus core. It's not usually detected in the blood, but its antibodies (anti-HBc) are used to diagnose past or present hepatitis B infection.

3. HBeAg (Hepatitis B e antigen): This is a protein found inside the hepatitis B virus core and is associated with viral replication. Its presence in the blood indicates high levels of viral replication, increased infectivity, and higher risk of liver damage. It's used to monitor disease progression and treatment response.

These antigens play a crucial role in the diagnosis, management, and prevention of hepatitis B infection.

A viral vaccine is a biological preparation that introduces your body to a specific virus in a way that helps your immune system build up protection against the virus without causing the illness. Viral vaccines can be made from weakened or inactivated forms of the virus, or parts of the virus such as proteins or sugars. Once introduced to the body, the immune system recognizes the virus as foreign and produces an immune response, including the production of antibodies. These antibodies remain in the body and provide immunity against future infection with that specific virus.

Viral vaccines are important tools for preventing infectious diseases caused by viruses, such as influenza, measles, mumps, rubella, polio, hepatitis A and B, rabies, rotavirus, chickenpox, shingles, and some types of cancer. Vaccination programs have led to the control or elimination of many infectious diseases that were once common.

It's important to note that viral vaccines are not effective against bacterial infections, and separate vaccines must be developed for each type of virus. Additionally, because viruses can mutate over time, it is necessary to update some viral vaccines periodically to ensure continued protection.

Hepatitis viruses refer to a group of viral agents that primarily target the liver, causing inflammation and damage to hepatocytes (liver cells). This results in various clinical manifestations, ranging from an acute infection to a chronic, persistent infection. There are five main types of hepatitis viruses, named Hepatitis A, B, C, D, and E virus, each with distinct genetic material, modes of transmission, and disease severity.

1. Hepatitis A Virus (HAV): This is a single-stranded RNA virus that is primarily transmitted through the fecal-oral route, often via contaminated food or water. Infected individuals may experience symptoms such as jaundice, fatigue, abdominal pain, and loss of appetite. While most people recover completely within a few months, severe complications can occur in rare cases. A vaccine is available to prevent HAV infection.
2. Hepatitis B Virus (HBV): This is a double-stranded DNA virus that is primarily transmitted through contact with infected blood or bodily fluids, such as during sexual contact, sharing needles, or from mother to child during childbirth. HBV can cause both acute and chronic hepatitis, which may lead to severe liver complications like cirrhosis and liver cancer if left untreated. A vaccine is available to prevent HBV infection.
3. Hepatitis C Virus (HCV): This is a single-stranded RNA virus that is primarily transmitted through contact with infected blood, often through sharing needles or during medical procedures using contaminated equipment. Like HBV, HCV can cause both acute and chronic hepatitis, which may lead to severe liver complications if left untreated. No vaccine is currently available for HCV; however, antiviral treatments can cure the infection in many cases.
4. Hepatitis D Virus (HDV): This is a defective RNA virus that requires the presence of HBV to replicate and cause infection. HDV is primarily transmitted through contact with infected blood or bodily fluids, similar to HBV. Co-infection with both HBV and HDV can result in more severe liver disease compared to HBV infection alone. Antiviral treatments are available for HDV; however, a vaccine is not.
5. Hepatitis E Virus (HEV): This is a single-stranded RNA virus that primarily causes acute hepatitis and is usually transmitted through the fecal-oral route, often through contaminated food or water. In most cases, HEV infection resolves on its own without treatment. However, in pregnant women and individuals with weakened immune systems, HEV can cause severe liver complications. No vaccine is currently available for HEV in the United States; however, a vaccine has been approved in some countries.

Hepatitis antibodies are proteins produced by the immune system in response to an infection caused by a hepatitis virus. There are several types of hepatitis viruses, including A, B, C, D, and E, each with their own specific antibodies.

The presence of hepatitis antibodies in the blood can indicate a current or past infection with the corresponding hepatitis virus. For example, the detection of anti-HAV (hepatitis A virus) antibodies indicates a past infection or immunization against hepatitis A, while the detection of anti-HBs (hepatitis B surface antigen) antibodies indicates immunity due to vaccination or recovery from a hepatitis B infection.

It's important to note that some hepatitis antibodies may not provide immunity to future infections, and individuals can still be infected with the virus even if they have previously produced antibodies against it. Therefore, regular testing and vaccination are essential for preventing the spread of hepatitis viruses and protecting public health.

I'm sorry for any confusion, but "Viral Hepatitis, Animal" is not a standard medical classification or definition. Hepatitis refers to inflammation of the liver, and viral hepatitis refers to inflammation caused by a virus. The term "animal" in this context doesn't provide a clear meaning.

However, it's worth noting that some animals can contract viral hepatitis, similar to humans. For instance, there are hepatitis A, B, and C-like viruses that have been identified in various animal species. These are typically not transmissible to humans.

If you're referring to a specific medical condition or context, could you please provide more details? I'd be happy to help further with more information.

Synthetic vaccines are artificially produced, designed to stimulate an immune response and provide protection against specific diseases. Unlike traditional vaccines that are derived from weakened or killed pathogens, synthetic vaccines are created using synthetic components, such as synthesized viral proteins, DNA, or RNA. These components mimic the disease-causing agent and trigger an immune response without causing the actual disease. The use of synthetic vaccines offers advantages in terms of safety, consistency, and scalability in production, making them valuable tools for preventing infectious diseases.

I could not find a specific medical definition for "Vaccines, DNA." However, I can provide you with some information about DNA vaccines.

DNA vaccines are a type of vaccine that uses genetically engineered DNA to stimulate an immune response in the body. They work by introducing a small piece of DNA into the body that contains the genetic code for a specific antigen (a substance that triggers an immune response). The cells of the body then use this DNA to produce the antigen, which prompts the immune system to recognize and attack it.

DNA vaccines have several advantages over traditional vaccines. They are relatively easy to produce, can be stored at room temperature, and can be designed to protect against a wide range of diseases. Additionally, because they use DNA to stimulate an immune response, DNA vaccines do not require the growth and culture of viruses or bacteria, which can make them safer than traditional vaccines.

DNA vaccines are still in the experimental stages, and more research is needed to determine their safety and effectiveness. However, they have shown promise in animal studies and are being investigated as a potential tool for preventing a variety of infectious diseases, including influenza, HIV, and cancer.

Hepatitis E is a viral infection that specifically affects the liver, caused by the hepatitis E virus (HEV). The disease is primarily transmitted through the fecal-oral route, often through contaminated water or food. It can also be spread through blood transfusions and vertical transmission from mother to fetus.

The incubation period for hepatitis E ranges from 2 to 10 weeks. Symptoms of the disease are similar to other types of viral hepatitis and may include jaundice (yellowing of the skin and eyes), fatigue, loss of appetite, abdominal pain, nausea, vomiting, joint pain, and dark urine.

In most cases, hepatitis E is a self-limiting disease, meaning that it resolves on its own within a few weeks to months. However, in some individuals, particularly those with weakened immune systems, the infection can lead to severe complications such as acute liver failure and death. Pregnant women, especially those in the third trimester, are at higher risk of developing severe disease and have a mortality rate of up to 25%.

Prevention measures include maintaining good hygiene practices, practicing safe food handling and preparation, and ensuring access to clean water sources. Currently, there is no specific treatment for hepatitis E, but supportive care can help manage symptoms. Vaccines are available in some countries to prevent the disease.

Combined vaccines are defined in medical terms as vaccines that contain two or more antigens from different diseases, which are given to provide protection against multiple diseases at the same time. This approach reduces the number of injections required and simplifies the immunization schedule, especially during early childhood. Examples of combined vaccines include:

1. DTaP-Hib-IPV (e.g., Pentacel): A vaccine that combines diphtheria, tetanus, pertussis (whooping cough), Haemophilus influenzae type b (Hib) disease, and poliovirus components in one injection to protect against these five diseases.
2. MMRV (e.g., ProQuad): A vaccine that combines measles, mumps, rubella, and varicella (chickenpox) antigens in a single injection to provide immunity against all four diseases.
3. HepA-HepB (e.g., Twinrix): A vaccine that combines hepatitis A and hepatitis B antigens in one injection, providing protection against both types of hepatitis.
4. MenACWY-TT (e.g., MenQuadfi): A vaccine that combines four serogroups of meningococcal bacteria (A, C, W, Y) with tetanus toxoid as a carrier protein in one injection for the prevention of invasive meningococcal disease caused by these serogroups.
5. PCV13-PPSV23 (e.g., Vaxneuvance): A vaccine that combines 13 pneumococcal serotypes with PPSV23, providing protection against a broader range of pneumococcal diseases in adults aged 18 years and older.

Combined vaccines have been thoroughly tested for safety and efficacy to ensure they provide a strong immune response and an acceptable safety profile. They are essential tools in preventing various infectious diseases and improving overall public health.

Hepatitis A antibodies are proteins produced by the immune system in response to a Hepatitis A virus infection or after vaccination. There are two types of Hepatitis A antibodies:

1. IgM anti-HAV (Hepatitis A Virus) antibodies: These are the first type of antibodies produced by the immune system during a Hepatitis A infection. They appear in the blood within 2 to 4 weeks after exposure to the virus and remain detectable for up to 12 weeks. The presence of IgM anti-HAV antibodies indicates a recent or ongoing Hepatitis A infection.

2. IgG anti-HAV antibodies: These are the second type of antibodies produced by the immune system during a Hepatitis A infection, and they appear in the blood several weeks after the onset of illness. IgG anti-HAV antibodies remain detectable for many years, providing long-term immunity against future Hepatitis A infections. After vaccination, only IgG anti-HAV antibodies are produced, indicating immunity to Hepatitis A.

Testing for Hepatitis A antibodies is used to diagnose acute or past Hepatitis A infections and to assess immunity following vaccination.

Bacterial vaccines are types of vaccines that are created using bacteria or parts of bacteria as the immunogen, which is the substance that triggers an immune response in the body. The purpose of a bacterial vaccine is to stimulate the immune system to develop protection against specific bacterial infections.

There are several types of bacterial vaccines, including:

1. Inactivated or killed whole-cell vaccines: These vaccines contain entire bacteria that have been killed or inactivated through various methods, such as heat or chemicals. The bacteria can no longer cause disease, but they still retain the ability to stimulate an immune response.
2. Subunit, protein, or polysaccharide vaccines: These vaccines use specific components of the bacterium, such as proteins or polysaccharides, that are known to trigger an immune response. By using only these components, the vaccine can avoid using the entire bacterium, which may reduce the risk of adverse reactions.
3. Live attenuated vaccines: These vaccines contain live bacteria that have been weakened or attenuated so that they cannot cause disease but still retain the ability to stimulate an immune response. This type of vaccine can provide long-lasting immunity, but it may not be suitable for people with weakened immune systems.

Bacterial vaccines are essential tools in preventing and controlling bacterial infections, reducing the burden of diseases such as tuberculosis, pneumococcal disease, meningococcal disease, and Haemophilus influenzae type b (Hib) disease. They work by exposing the immune system to a harmless form of the bacteria or its components, which triggers the production of antibodies and memory cells that can recognize and fight off future infections with that same bacterium.

It's important to note that while vaccines are generally safe and effective, they may cause mild side effects such as pain, redness, or swelling at the injection site, fever, or fatigue. Serious side effects are rare but can occur, so it's essential to consult with a healthcare provider before receiving any vaccine.

Hepatitis D, also known as Delta hepatitis, is a viral infection of the liver that can only occur in people who have a current infection with the hepatitis B virus (HBV). It's caused by the hepatitis delta virus (HDV), which is a small, enveloped, single-stranded RNA virus.

HDV requires the presence of HBV for its replication and survival, so it can't infect someone who doesn't already have HBV. When both viruses are present, they can interact in ways that lead to more severe liver disease than either virus would cause alone.

Hepatitis D can be an acute or chronic infection, and it can range from mild to severe, with symptoms similar to those of other types of viral hepatitis, such as jaundice, fatigue, loss of appetite, nausea, vomiting, abdominal pain, and joint pain. In some cases, hepatitis D can lead to serious complications, including liver failure and death.

Hepatitis D is primarily spread through contact with infected blood or other bodily fluids, such as during sexual contact, sharing needles, or mother-to-child transmission during childbirth. It's preventable through vaccination against hepatitis B, which provides immunity to both viruses. There is no specific treatment for hepatitis D, but antiviral therapy for hepatitis B can help manage the infection and prevent complications.

Hepacivirus is a genus of viruses in the family Flaviviridae. The most well-known member of this genus is Hepatitis C virus (HCV), which is a major cause of liver disease worldwide. HCV infection can lead to chronic hepatitis, cirrhosis, and liver cancer.

Hepaciviruses are enveloped viruses with a single-stranded, positive-sense RNA genome. They have a small icosahedral capsid and infect a variety of hosts, including humans, non-human primates, horses, and birds. The virus enters the host cell by binding to specific receptors on the cell surface and is then internalized through endocytosis.

HCV has a high degree of genetic diversity and is classified into seven major genotypes and numerous subtypes based on differences in its RNA sequence. This genetic variability can affect the virus's ability to evade the host immune response, making treatment more challenging.

In addition to HCV, other hepaciviruses have been identified in various animal species, including equine hepacivirus (EHCV), rodent hepacivirus (RHV), and bat hepacivirus (BtHepCV). These viruses are being studied to better understand the biology of hepaciviruses and their potential impact on human health.

Hepatitis E virus (HEV) is a single-stranded, positive-sense RNA virus that belongs to the family Hepeviridae and genus Orthohepevirus. It primarily infects the liver, causing acute hepatitis in humans. The virus is transmitted through the fecal-oral route, often through contaminated water or food sources. Ingestion of raw or undercooked pork or deer meat can also lead to HEV infection.

HEV infection typically results in self-limiting acute hepatitis, characterized by symptoms such as jaundice, fatigue, loss of appetite, abdominal pain, and dark urine. In some cases, particularly among pregnant women and individuals with weakened immune systems, HEV infection can lead to severe complications, including fulminant hepatic failure and death.

There are four main genotypes of HEV that infect humans: genotype 1 and 2 are primarily found in developing countries and are transmitted through contaminated water; genotype 3 and 4 are found worldwide and can be transmitted through both zoonotic and human-to-human routes.

Prevention measures include improving sanitation, access to clean water, and food safety practices. Currently, there is no specific antiviral treatment for HEV infection, but supportive care can help manage symptoms. A vaccine against HEV is available in China and has shown efficacy in preventing the disease.

Hepatitis C antibodies are proteins produced by the immune system in response to an infection with the hepatitis C virus (HCV). Detection of these antibodies in the blood indicates a past or present HCV infection. However, it does not necessarily mean that the person is currently infected, as antibodies can persist for years even after the virus has been cleared from the body. Additional tests are usually needed to confirm whether the infection is still active and to guide treatment decisions.

Hepatitis B core antigen (HBcAg) is a protein found in the core of the hepatitis B virus (HBV). It is present during active replication of the virus and plays a crucial role in the formation of the viral capsid or core. The antibodies produced against HBcAg (anti-HBc) can be detected in the blood, which serves as a marker for current or past HBV infection. It is important to note that HBcAg itself is not detectable in the blood because it is confined within the viral particle. However, during the serological testing of hepatitis B, the detection of anti-HBc IgM indicates a recent acute infection, while the presence of anti-HBc IgG suggests either a past resolved infection or an ongoing chronic infection.

Hepatitis A Virus, Human (HAV): A single-stranded, positive-sense RNA virus belonging to the Picornaviridae family, specifically the Hepatovirus genus. It is the causative agent of Hepatitis A, a viral infection that primarily affects the liver. The virus is typically transmitted through the fecal-oral route, often via contaminated food or water, or close contact with an infected individual. Following incubation (15-50 days), symptoms may include jaundice, fatigue, abdominal pain, loss of appetite, nausea, diarrhea, and fever. Most people recover completely within a few weeks; however, severe complications and death are possible, especially in individuals with preexisting liver disease. Prevention is primarily achieved through vaccination and practicing good hygiene.

Hepatovirus is a genus of viruses in the Picornaviridae family, and it's most notably represented by the Human Hepatitis A Virus (HAV). These viruses are non-enveloped, with a single-stranded, positive-sense RNA genome. They primarily infect hepatocytes, causing liver inflammation and disease, such as hepatitis. Transmission of hepatoviruses typically occurs through the fecal-oral route, often via contaminated food or water. The virus causes an acute infection that does not usually become chronic, and recovery is usually complete within a few weeks. Immunity after infection is solid and lifelong.

Liver cirrhosis is a chronic, progressive disease characterized by the replacement of normal liver tissue with scarred (fibrotic) tissue, leading to loss of function. The scarring is caused by long-term damage from various sources such as hepatitis, alcohol abuse, nonalcoholic fatty liver disease, and other causes. As the disease advances, it can lead to complications like portal hypertension, fluid accumulation in the abdomen (ascites), impaired brain function (hepatic encephalopathy), and increased risk of liver cancer. It is generally irreversible, but early detection and treatment of underlying causes may help slow down its progression.

An AIDS vaccine is a type of preventive vaccine that aims to stimulate the immune system to produce an effective response against the human immunodeficiency virus (HIV), which causes acquired immunodeficiency syndrome (AIDS). The goal of an AIDS vaccine is to induce the production of immune cells and proteins that can recognize and eliminate HIV-infected cells, thereby preventing the establishment of a persistent infection.

Despite decades of research, there is still no licensed AIDS vaccine available. This is due in part to the unique challenges posed by HIV, which has a high mutation rate and can rapidly evolve to evade the immune system's defenses. However, several promising vaccine candidates are currently being tested in clinical trials around the world, and researchers continue to explore new approaches and strategies for developing an effective AIDS vaccine.

Hepatitis B e antigen (HBeAg) is a protein produced by the hepatitis B virus (HBV) during its replication process. It can be found in the blood of individuals infected with HBV. The presence of HBeAg generally indicates that the virus is actively replicating in the liver and that the individual has high levels of viral load.

HBeAg is a serological marker used to assess the severity and activity of HBV infection, as well as the response to antiviral treatment. In particular, the disappearance of HBeAg from the blood (known as seroconversion) is often associated with a decrease in viral replication and an improvement in liver disease. However, the presence of HBeAg does not necessarily mean that the individual will develop symptoms or liver damage, as some people can remain asymptomatic carriers of the virus for many years.

It's important to note that not all HBV strains produce HBeAg, and some mutant strains may not produce detectable levels of this antigen even when the virus is actively replicating. Therefore, additional tests may be needed to confirm the presence or absence of HBV infection in these cases.

I'm sorry for any confusion, but "Animal Hepatitis" is not a medical term used to describe a specific disease. Hepatitis refers to inflammation of the liver, and it can be caused by various factors, including viruses, alcohol, drugs, and certain medical conditions.

However, there are several viral hepatitis types that can infect animals, such as Hepatitis A, B, and C, which primarily affect humans. But there are also other hepatitis viruses that are species-specific and primarily infect animals, such as:

1. Canine Hepatitis (Adenovirus Type 1): This is a viral infection that affects dogs and causes liver damage, respiratory signs, and occasionally death.
2. Feline Infectious Peritonitis (FIP) Virus: While not strictly a hepatitis virus, this feline coronavirus can cause severe inflammation of the liver and other organs in cats.
3. Equine Infectious Anemia Virus (EIAV): This retrovirus affects horses and causes cyclic fever, anemia, and occasionally liver disease.
4. Avian Hepatitis E Virus: A recently discovered virus that infects birds and can cause hepatitis and other systemic signs in chickens and other avian species.

If you're looking for information on a specific animal hepatitis virus or a different medical term, please provide more context so I can give you a more accurate answer.

Vaccination is a simple, safe, and effective way to protect people against harmful diseases, before they come into contact with them. It uses your body's natural defenses to build protection to specific infections and makes your immune system stronger.

A vaccination usually contains a small, harmless piece of a virus or bacteria (or toxins produced by these germs) that has been made inactive or weakened so it won't cause the disease itself. This piece of the germ is known as an antigen. When the vaccine is introduced into the body, the immune system recognizes the antigen as foreign and produces antibodies to fight it.

If a person then comes into contact with the actual disease-causing germ, their immune system will recognize it and immediately produce antibodies to destroy it. The person is therefore protected against that disease. This is known as active immunity.

Vaccinations are important for both individual and public health. They prevent the spread of contagious diseases and protect vulnerable members of the population, such as young children, the elderly, and people with weakened immune systems who cannot be vaccinated or for whom vaccination is not effective.

A subunit vaccine is a type of vaccine that contains a specific piece or component of the microorganism (such as a protein, sugar, or part of the bacterial outer membrane), instead of containing the entire organism. This piece of the microorganism is known as an antigen, and it stimulates an immune response in the body, allowing the development of immunity against the targeted infection without introducing the risk of disease associated with live vaccines.

Subunit vaccines offer several advantages over other types of vaccines. They are generally safer because they do not contain live or weakened microorganisms, making them suitable for individuals with weakened immune systems or specific medical conditions that prevent them from receiving live vaccines. Additionally, subunit vaccines can be designed to focus on the most immunogenic components of a pathogen, potentially leading to stronger and more targeted immune responses.

Examples of subunit vaccines include the Hepatitis B vaccine, which contains a viral protein, and the Haemophilus influenzae type b (Hib) vaccine, which uses pieces of the bacterial polysaccharide capsule. These vaccines have been crucial in preventing serious infectious diseases and reducing associated complications worldwide.

Conjugate vaccines are a type of vaccine that combines a part of a bacterium with a protein or other substance to boost the body's immune response to the bacteria. The bacterial component is usually a polysaccharide, which is a long chain of sugars that makes up part of the bacterial cell wall.

By itself, a polysaccharide is not very immunogenic, meaning it does not stimulate a strong immune response. However, when it is conjugated or linked to a protein or other carrier molecule, it becomes much more immunogenic and can elicit a stronger and longer-lasting immune response.

Conjugate vaccines are particularly effective in protecting against bacterial infections that affect young children, such as Haemophilus influenzae type b (Hib) and pneumococcal disease. These vaccines have been instrumental in reducing the incidence of these diseases and their associated complications, such as meningitis and pneumonia.

Overall, conjugate vaccines work by mimicking a natural infection and stimulating the immune system to produce antibodies that can protect against future infections with the same bacterium. By combining a weakly immunogenic polysaccharide with a protein carrier, these vaccines can elicit a stronger and more effective immune response, providing long-lasting protection against bacterial infections.

Jaundice is a medical condition characterized by the yellowing of the skin, sclera (whites of the eyes), and mucous membranes due to an excess of bilirubin in the bloodstream. Bilirubin is a yellow-orange pigment produced when hemoglobin from red blood cells is broken down. Normally, bilirubin is processed by the liver and excreted through bile into the digestive system. However, if there's an issue with bilirubin metabolism or elimination, it can accumulate in the body, leading to jaundice.

Jaundice can be a symptom of various underlying conditions, such as liver diseases (hepatitis, cirrhosis), gallbladder issues (gallstones, tumors), or blood disorders (hemolysis). It is essential to consult a healthcare professional if jaundice is observed, as it may indicate a severe health problem requiring prompt medical attention.

Autoimmune hepatitis is a chronic (long-term) disease in which the body's immune system mistakenly attacks the liver, leading to inflammation and damage. This results in decreased liver function over time if not treated. The exact cause of autoimmune hepatitis is unknown, but it is believed to be associated with genetic factors and exposure to certain environmental triggers, such as viral infections or medications.

There are two main types of autoimmune hepatitis:

1. Type 1 (classic) autoimmune hepatitis: This form can affect both adults and children, and it is more common in women than men. People with this type may also have other autoimmune disorders, such as rheumatoid arthritis, thyroid disease, or ulcerative colitis.
2. Type 2 autoimmune hepatitis: This form primarily affects children and young women. It is less common than type 1 and tends to be more severe. People with this type may also have other autoimmune disorders, such as celiac disease or chronic candidiasis.

Symptoms of autoimmune hepatitis can vary widely, from mild to severe. They may include fatigue, loss of appetite, nausea, vomiting, abdominal pain, joint pain, jaundice (yellowing of the skin and eyes), dark urine, and light-colored stools.

Diagnosis typically involves blood tests, imaging studies, and sometimes a liver biopsy to assess the extent of damage. Treatment usually includes medications that suppress the immune system, such as corticosteroids and immunosuppressants, which can help reduce inflammation and slow or stop liver damage. In some cases, lifestyle changes and supportive care may also be necessary.

Hepatitis Delta Virus (HDV) is not a traditional virus but rather a defective RNA particle that requires the assistance of the hepatitis B virus (HBV) to replicate. It's also known as delta agent or hepatitis D. HDV is a unique pathogen that only infects individuals who are already infected with HBV.

The virus causes a more severe form of viral hepatitis than HBV alone, leading to a higher risk of fulminant hepatitis (acute liver failure) and chronic hepatitis, which can progress to cirrhosis and hepatocellular carcinoma. HDV is primarily transmitted through percutaneous or sexual contact with infected blood or body fluids.

Prevention strategies include vaccination against HBV, which also prevents HDV infection, and avoiding high-risk behaviors such as intravenous drug use and unprotected sex with multiple partners. There is no specific treatment for HDV; however, antiviral therapy for HBV can help manage the infection.

Alanine transaminase (ALT) is a type of enzyme found primarily in the cells of the liver and, to a lesser extent, in the cells of other tissues such as the heart, muscles, and kidneys. Its primary function is to catalyze the reversible transfer of an amino group from alanine to another alpha-keto acid, usually pyruvate, to form pyruvate and another amino acid, usually glutamate. This process is known as the transamination reaction.

When liver cells are damaged or destroyed due to various reasons such as hepatitis, alcohol abuse, nonalcoholic fatty liver disease, or drug-induced liver injury, ALT is released into the bloodstream. Therefore, measuring the level of ALT in the blood is a useful diagnostic tool for evaluating liver function and detecting liver damage. Normal ALT levels vary depending on the laboratory, but typically range from 7 to 56 units per liter (U/L) for men and 6 to 45 U/L for women. Elevated ALT levels may indicate liver injury or disease, although other factors such as muscle damage or heart disease can also cause elevations in ALT.

Antiviral agents are a class of medications that are designed to treat infections caused by viruses. Unlike antibiotics, which target bacteria, antiviral agents interfere with the replication and infection mechanisms of viruses, either by inhibiting their ability to replicate or by modulating the host's immune response to the virus.

Antiviral agents are used to treat a variety of viral infections, including influenza, herpes simplex virus (HSV) infections, human immunodeficiency virus (HIV) infection, hepatitis B and C, and respiratory syncytial virus (RSV) infections.

These medications can be administered orally, intravenously, or topically, depending on the type of viral infection being treated. Some antiviral agents are also used for prophylaxis, or prevention, of certain viral infections.

It is important to note that antiviral agents are not effective against all types of viruses and may have significant side effects. Therefore, it is essential to consult with a healthcare professional before starting any antiviral therapy.

Liver diseases refer to a wide range of conditions that affect the normal functioning of the liver. The liver is a vital organ responsible for various critical functions such as detoxification, protein synthesis, and production of biochemicals necessary for digestion.

Liver diseases can be categorized into acute and chronic forms. Acute liver disease comes on rapidly and can be caused by factors like viral infections (hepatitis A, B, C, D, E), drug-induced liver injury, or exposure to toxic substances. Chronic liver disease develops slowly over time, often due to long-term exposure to harmful agents or inherent disorders of the liver.

Common examples of liver diseases include hepatitis, cirrhosis (scarring of the liver tissue), fatty liver disease, alcoholic liver disease, autoimmune liver diseases, genetic/hereditary liver disorders (like Wilson's disease and hemochromatosis), and liver cancers. Symptoms may vary widely depending on the type and stage of the disease but could include jaundice, abdominal pain, fatigue, loss of appetite, nausea, and weight loss.

Early diagnosis and treatment are essential to prevent progression and potential complications associated with liver diseases.

The liver is a large, solid organ located in the upper right portion of the abdomen, beneath the diaphragm and above the stomach. It plays a vital role in several bodily functions, including:

1. Metabolism: The liver helps to metabolize carbohydrates, fats, and proteins from the food we eat into energy and nutrients that our bodies can use.
2. Detoxification: The liver detoxifies harmful substances in the body by breaking them down into less toxic forms or excreting them through bile.
3. Synthesis: The liver synthesizes important proteins, such as albumin and clotting factors, that are necessary for proper bodily function.
4. Storage: The liver stores glucose, vitamins, and minerals that can be released when the body needs them.
5. Bile production: The liver produces bile, a digestive juice that helps to break down fats in the small intestine.
6. Immune function: The liver plays a role in the immune system by filtering out bacteria and other harmful substances from the blood.

Overall, the liver is an essential organ that plays a critical role in maintaining overall health and well-being.

Malaria vaccines are biological preparations that induce immunity against malaria parasites, thereby preventing or reducing the severity of malaria disease. They typically contain antigens (proteins or other molecules derived from the parasite) that stimulate an immune response in the recipient, enabling their body to recognize and neutralize the pathogen upon exposure.

The most advanced malaria vaccine candidate is RTS,S/AS01 (Mosquirix), which targets the Plasmodium falciparum parasite's circumsporozoite protein (CSP). This vaccine has shown partial protection in clinical trials, reducing the risk of severe malaria and hospitalization in young children by about 30% over four years. However, it does not provide complete immunity, and additional research is ongoing to develop more effective vaccines against malaria.

Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer in adults. It originates from the hepatocytes, which are the main functional cells of the liver. This type of cancer is often associated with chronic liver diseases such as cirrhosis caused by hepatitis B or C virus infection, alcohol abuse, non-alcoholic fatty liver disease (NAFLD), and aflatoxin exposure.

The symptoms of HCC can vary but may include unexplained weight loss, lack of appetite, abdominal pain or swelling, jaundice, and fatigue. The diagnosis of HCC typically involves imaging tests such as ultrasound, CT scan, or MRI, as well as blood tests to measure alpha-fetoprotein (AFP) levels. Treatment options for Hepatocellular carcinoma depend on the stage and extent of the cancer, as well as the patient's overall health and liver function. Treatment options may include surgery, radiation therapy, chemotherapy, targeted therapy, or liver transplantation.

Papillomavirus vaccines are vaccines that have been developed to prevent infection by human papillomaviruses (HPV). HPV is a DNA virus that is capable of infecting the skin and mucous membranes. Certain types of HPV are known to cause cervical cancer, as well as other types of cancer such as anal, penile, vulvar, and oropharyngeal cancers. Other types of HPV can cause genital warts.

There are currently two papillomavirus vaccines that have been approved for use in the United States: Gardasil and Cervarix. Both vaccines protect against the two most common cancer-causing types of HPV (types 16 and 18), which together cause about 70% of cervical cancers. Gardasil also protects against the two most common types of HPV that cause genital warts (types 6 and 11).

Papillomavirus vaccines are given as a series of three shots over a period of six months. They are most effective when given to people before they become sexually active, as this reduces the risk of exposure to HPV. The Centers for Disease Control and Prevention (CDC) recommends that all boys and girls get vaccinated against HPV at age 11 or 12, but the vaccine can be given to people as young as age 9 and as old as age 26.

It is important to note that papillomavirus vaccines do not protect against all types of HPV, and they do not treat existing HPV infections or cervical cancer. They are intended to prevent new HPV infections and the cancers and other diseases that can be caused by HPV.

Liver neoplasms refer to abnormal growths in the liver that can be benign or malignant. Benign liver neoplasms are non-cancerous tumors that do not spread to other parts of the body, while malignant liver neoplasms are cancerous tumors that can invade and destroy surrounding tissue and spread to other organs.

Liver neoplasms can be primary, meaning they originate in the liver, or secondary, meaning they have metastasized (spread) to the liver from another part of the body. Primary liver neoplasms can be further classified into different types based on their cell of origin and behavior, including hepatocellular carcinoma, cholangiocarcinoma, and hepatic hemangioma.

The diagnosis of liver neoplasms typically involves a combination of imaging studies, such as ultrasound, CT scan, or MRI, and biopsy to confirm the type and stage of the tumor. Treatment options depend on the type and extent of the neoplasm and may include surgery, radiation therapy, chemotherapy, or liver transplantation.

An acute disease is a medical condition that has a rapid onset, develops quickly, and tends to be short in duration. Acute diseases can range from minor illnesses such as a common cold or flu, to more severe conditions such as pneumonia, meningitis, or a heart attack. These types of diseases often have clear symptoms that are easy to identify, and they may require immediate medical attention or treatment.

Acute diseases are typically caused by an external agent or factor, such as a bacterial or viral infection, a toxin, or an injury. They can also be the result of a sudden worsening of an existing chronic condition. In general, acute diseases are distinct from chronic diseases, which are long-term medical conditions that develop slowly over time and may require ongoing management and treatment.

Examples of acute diseases include:

* Acute bronchitis: a sudden inflammation of the airways in the lungs, often caused by a viral infection.
* Appendicitis: an inflammation of the appendix that can cause severe pain and requires surgical removal.
* Gastroenteritis: an inflammation of the stomach and intestines, often caused by a viral or bacterial infection.
* Migraine headaches: intense headaches that can last for hours or days, and are often accompanied by nausea, vomiting, and sensitivity to light and sound.
* Myocardial infarction (heart attack): a sudden blockage of blood flow to the heart muscle, often caused by a buildup of plaque in the coronary arteries.
* Pneumonia: an infection of the lungs that can cause coughing, chest pain, and difficulty breathing.
* Sinusitis: an inflammation of the sinuses, often caused by a viral or bacterial infection.

It's important to note that while some acute diseases may resolve on their own with rest and supportive care, others may require medical intervention or treatment to prevent complications and promote recovery. If you are experiencing symptoms of an acute disease, it is always best to seek medical attention to ensure proper diagnosis and treatment.

Murine hepatitis virus (MHV) is a type of coronavirus that primarily infects laboratory mice. It is not related to the human hepatitis viruses A, B, C, D, or E. MHV causes a range of diseases in mice, including hepatitis (liver inflammation), encephalomyelitis (inflammation of the brain and spinal cord), and enteritis (inflammation of the intestine). The virus is transmitted through fecal-oral route and respiratory droplets. It's widely used in research to understand the pathogenesis, immunity, and molecular biology of coronaviruses.

Antibodies, viral are proteins produced by the immune system in response to an infection with a virus. These antibodies are capable of recognizing and binding to specific antigens on the surface of the virus, which helps to neutralize or destroy the virus and prevent its replication. Once produced, these antibodies can provide immunity against future infections with the same virus.

Viral antibodies are typically composed of four polypeptide chains - two heavy chains and two light chains - that are held together by disulfide bonds. The binding site for the antigen is located at the tip of the Y-shaped structure, formed by the variable regions of the heavy and light chains.

There are five classes of antibodies in humans: IgA, IgD, IgE, IgG, and IgM. Each class has a different function and is distributed differently throughout the body. For example, IgG is the most common type of antibody found in the bloodstream and provides long-term immunity against viruses, while IgA is found primarily in mucous membranes and helps to protect against respiratory and gastrointestinal infections.

In addition to their role in the immune response, viral antibodies can also be used as diagnostic tools to detect the presence of a specific virus in a patient's blood or other bodily fluids.

Interferon-alpha (IFN-α) is a type I interferon, which is a group of signaling proteins made and released by host cells in response to the presence of viruses, parasites, and tumor cells. It plays a crucial role in the immune response against viral infections. IFN-α has antiviral, immunomodulatory, and anti-proliferative effects.

IFN-α is produced naturally by various cell types, including leukocytes (white blood cells), fibroblasts, and epithelial cells, in response to viral or bacterial stimulation. It binds to specific receptors on the surface of nearby cells, triggering a signaling cascade that leads to the activation of genes involved in the antiviral response. This results in the production of proteins that inhibit viral replication and promote the presentation of viral antigens to the immune system, enhancing its ability to recognize and eliminate infected cells.

In addition to its role in the immune response, IFN-α has been used as a therapeutic agent for various medical conditions, including certain types of cancer, chronic hepatitis B and C, and multiple sclerosis. However, its use is often limited by side effects such as flu-like symptoms, depression, and neuropsychiatric disorders.

Liver function tests (LFTs) are a group of blood tests that are used to assess the functioning and health of the liver. These tests measure the levels of various enzymes, proteins, and waste products that are produced or metabolized by the liver. Some common LFTs include:

1. Alanine aminotransferase (ALT): An enzyme found primarily in the liver, ALT is released into the bloodstream in response to liver cell damage. Elevated levels of ALT may indicate liver injury or disease.
2. Aspartate aminotransferase (AST): Another enzyme found in various tissues, including the liver, heart, and muscles. Like ALT, AST is released into the bloodstream following tissue damage. High AST levels can be a sign of liver damage or other medical conditions.
3. Alkaline phosphatase (ALP): An enzyme found in several organs, including the liver, bile ducts, and bones. Elevated ALP levels may indicate a blockage in the bile ducts, liver disease, or bone disorders.
4. Gamma-glutamyl transferase (GGT): An enzyme found mainly in the liver, pancreas, and biliary system. Increased GGT levels can suggest liver disease, alcohol consumption, or the use of certain medications.
5. Bilirubin: A yellowish pigment produced when hemoglobin from red blood cells is broken down. Bilirubin is processed by the liver and excreted through bile. High bilirubin levels can indicate liver dysfunction, bile duct obstruction, or certain types of anemia.
6. Albumin: A protein produced by the liver that helps maintain fluid balance in the body and transports various substances in the blood. Low albumin levels may suggest liver damage, malnutrition, or kidney disease.
7. Total protein: A measure of all proteins present in the blood, including albumin and other types of proteins produced by the liver. Decreased total protein levels can indicate liver dysfunction or other medical conditions.

These tests are often ordered together as part of a routine health checkup or when evaluating symptoms related to liver function or disease. The results should be interpreted in conjunction with clinical findings, medical history, and other diagnostic tests.

Meningococcal vaccines are vaccines that protect against Neisseria meningitidis, a type of bacteria that can cause serious infections such as meningitis (inflammation of the lining of the brain and spinal cord) and septicemia (bloodstream infection). There are several types of meningococcal vaccines available, including conjugate vaccines and polysaccharide vaccines. These vaccines work by stimulating the immune system to produce antibodies that can protect against the different serogroups of N. meningitidis, including A, B, C, Y, and W-135. The specific type of vaccine used and the number of doses required may depend on a person's age, health status, and other factors. Meningococcal vaccines are recommended for certain high-risk populations, such as infants, young children, adolescents, and people with certain medical conditions, as well as for travelers to areas where meningococcal disease is common.

Aspartate aminotransferases (ASTs) are a group of enzymes found in various tissues throughout the body, including the heart, liver, and muscles. They play a crucial role in the metabolic process of transferring amino groups between different molecules.

In medical terms, AST is often used as a blood test to measure the level of this enzyme in the serum. Elevated levels of AST can indicate damage or injury to tissues that contain this enzyme, such as the liver or heart. For example, liver disease, including hepatitis and cirrhosis, can cause elevated AST levels due to damage to liver cells. Similarly, heart attacks can also result in increased AST levels due to damage to heart muscle tissue.

It is important to note that an AST test alone cannot diagnose a specific medical condition, but it can provide valuable information when used in conjunction with other diagnostic tests and clinical evaluation.

A viral RNA (ribonucleic acid) is the genetic material found in certain types of viruses, as opposed to viruses that contain DNA (deoxyribonucleic acid). These viruses are known as RNA viruses. The RNA can be single-stranded or double-stranded and can exist as several different forms, such as positive-sense, negative-sense, or ambisense RNA. Upon infecting a host cell, the viral RNA uses the host's cellular machinery to translate the genetic information into proteins, leading to the production of new virus particles and the continuation of the viral life cycle. Examples of human diseases caused by RNA viruses include influenza, COVID-19 (SARS-CoV-2), hepatitis C, and polio.

Alcoholic hepatitis is a medical condition characterized by inflammation and damage to the liver caused by excessive alcohol consumption. It is a type of hepatitis that specifically results from alcohol abuse, rather than from viral infections or other causes. The condition can vary in severity, and long-term heavy drinking increases the risk of developing alcoholic hepatitis.

The inflammation in alcoholic hepatitis can lead to symptoms such as jaundice (yellowing of the skin and eyes), abdominal pain, nausea, vomiting, loss of appetite, and fever. In severe cases, it can cause liver failure, which may be life-threatening. Treatment typically involves alcohol abstinence, supportive care, and medications to manage symptoms and prevent further liver damage. In some cases, hospitalization and more intensive treatments may be necessary.

Ribavirin is an antiviral medication used in the treatment of certain viral infections, including hepatitis C and respiratory syncytial virus (RSV) infection. It works by interfering with viral replication, preventing the virus from multiplying within infected cells. Ribavirin is often used in combination with other antiviral drugs for more effective treatment.

It's important to note that ribavirin can have serious side effects and should only be used under the supervision of a healthcare professional. Additionally, it is not effective against all types of viral infections and its use should be based on a confirmed diagnosis and appropriate medical evaluation.

Seroepidemiologic studies are a type of epidemiological study that measures the presence and levels of antibodies in a population's blood serum to investigate the prevalence, distribution, and transmission of infectious diseases. These studies help to identify patterns of infection and immunity within a population, which can inform public health policies and interventions.

Seroepidemiologic studies typically involve collecting blood samples from a representative sample of individuals in a population and testing them for the presence of antibodies against specific pathogens. The results are then analyzed to estimate the prevalence of infection and immunity within the population, as well as any factors associated with increased or decreased risk of infection.

These studies can provide valuable insights into the spread of infectious diseases, including emerging and re-emerging infections, and help to monitor the effectiveness of vaccination programs. Additionally, seroepidemiologic studies can also be used to investigate the transmission dynamics of infectious agents, such as identifying sources of infection or tracking the spread of antibiotic resistance.

A measles vaccine is a biological preparation that induces immunity against the measles virus. It contains an attenuated (weakened) strain of the measles virus, which stimulates the immune system to produce antibodies that protect against future infection with the wild-type (disease-causing) virus. Measles vaccines are typically administered in combination with vaccines against mumps and rubella (German measles), forming the MMR vaccine.

The measles vaccine is highly effective, with one or two doses providing immunity in over 95% of people who receive it. It is usually given to children as part of routine childhood immunization programs, with the first dose administered at 12-15 months of age and the second dose at 4-6 years of age.

Measles vaccination has led to a dramatic reduction in the incidence of measles worldwide and is considered one of the greatest public health achievements of the past century. However, despite widespread availability of the vaccine, measles remains a significant cause of morbidity and mortality in some parts of the world, particularly in areas with low vaccination coverage or where access to healthcare is limited.

Haemophilus vaccines are vaccines that are designed to protect against Haemophilus influenzae type b (Hib), a bacterium that can cause serious infections such as meningitis, pneumonia, and epiglottitis. There are two main types of Hib vaccines:

1. Polysaccharide vaccine: This type of vaccine is made from the sugar coating (polysaccharide) of the bacterial cells. It is not effective in children under 2 years of age because their immune systems are not yet mature enough to respond effectively to this type of vaccine.
2. Conjugate vaccine: This type of vaccine combines the polysaccharide with a protein carrier, which helps to stimulate a stronger and more sustained immune response. It is effective in infants as young as 6 weeks old.

Hib vaccines are usually given as part of routine childhood immunizations starting at 2 months of age. They are administered through an injection into the muscle. The vaccine is safe and effective, with few side effects. Vaccination against Hib has led to a significant reduction in the incidence of Hib infections worldwide.

Poliovirus Vaccine, Inactivated (IPV) is a vaccine used to prevent poliomyelitis (polio), a highly infectious disease caused by the poliovirus. IPV contains inactivated (killed) polioviruses of all three poliovirus types. It works by stimulating an immune response in the body, but because the viruses are inactivated, they cannot cause polio. After vaccination, the immune system recognizes and responds to the inactivated viruses, producing antibodies that protect against future infection with wild, or naturally occurring, polioviruses. IPV is typically given as an injection in the leg or arm, and a series of doses are required for full protection. It is a safe and effective way to prevent polio and its complications.

A Pertussis vaccine is a type of immunization used to protect against pertussis, also known as whooping cough. It contains components that stimulate the immune system to produce antibodies against the bacteria that cause pertussis, Bordetella pertussis. There are two main types of pertussis vaccines: whole-cell pertussis (wP) vaccines and acellular pertussis (aP) vaccines. wP vaccines contain killed whole cells of B. pertussis, while aP vaccines contain specific components of the bacteria, such as pertussis toxin and other antigens. Pertussis vaccines are often combined with diphtheria and tetanus to form combination vaccines, such as DTaP (diphtheria, tetanus, and acellular pertussis) and TdaP (tetanus, diphtheria, and acellular pertussis). These vaccines are typically given to young children as part of their routine immunization schedule.

BCG (Bacillus Calmette-Guérin) vaccine is a type of immunization used primarily to prevent tuberculosis (TB). It contains a live but weakened strain of Mycobacterium bovis, which is related to the bacterium that causes TB in humans (Mycobacterium tuberculosis).

The BCG vaccine works by stimulating an immune response in the body, enabling it to better resist infection with TB bacteria if exposed in the future. It is often given to infants and children in countries where TB is common, and its use varies depending on the national immunization policies. The protection offered by the BCG vaccine is moderate and may not last for a very long time.

In addition to its use against TB, the BCG vaccine has also been investigated for its potential therapeutic role in treating bladder cancer and some other types of cancer. The mechanism of action in these cases is thought to be related to the vaccine's ability to stimulate an immune response against abnormal cells.

Rabies vaccines are medical products that contain antigens of the rabies virus, which stimulate an immune response in individuals who receive them. The purpose of rabies vaccines is to prevent the development of rabies, a viral disease that is almost always fatal once symptoms appear.

There are two primary types of rabies vaccines available:

1. Pre-exposure prophylaxis (PrEP) vaccines: These vaccines are given to individuals who are at high risk of coming into contact with the rabies virus, such as veterinarians, animal handlers, and travelers visiting areas where rabies is common. The vaccine series typically consists of three doses given over a period of 28 days.
2. Post-exposure prophylaxis (PEP) vaccines: These vaccines are administered to individuals who have already been exposed to the rabies virus, usually through a bite or scratch from an infected animal. The vaccine series typically consists of four doses given over a period of 14 days, along with a dose of rabies immune globulin (RIG) to provide immediate protection while the immune system responds to the vaccine.

Both types of rabies vaccines are highly effective at preventing the disease, but it is essential to receive them as soon as possible after exposure or before potential exposure, as the virus can be fatal if left untreated.

Rotavirus vaccines are preventive measures used to protect against rotavirus infections, which are the leading cause of severe diarrhea and dehydration among infants and young children worldwide. These vaccines contain weakened or inactivated forms of the rotavirus, a pathogen that infects and causes symptoms by multiplying inside cells lining the small intestine.

The weakened or inactivated virus in the vaccine stimulates an immune response in the body, enabling it to recognize and fight off future rotavirus infections more effectively. The vaccines are usually administered orally, as a liquid droplet or on a sugar cube, to mimic natural infection through the gastrointestinal tract.

There are currently two licensed rotavirus vaccines available globally:

1. Rotarix (GlaxoSmithKline): This vaccine contains an attenuated (weakened) strain of human rotavirus and is given in a two-dose series, typically at 2 and 4 months of age.
2. RotaTeq (Merck): This vaccine contains five reassortant viruses, combining human and animal strains to provide broader protection. It is administered in a three-dose series, usually at 2, 4, and 6 months of age.

Rotavirus vaccines have been shown to significantly reduce the incidence of severe rotavirus gastroenteritis and related hospitalizations among infants and young children. The World Health Organization (WHO) recommends the inclusion of rotavirus vaccination in national immunization programs, particularly in countries with high child mortality rates due to diarrheal diseases.

Hepatitis B virus (Woodchuck) refers to the hepadnavirus that naturally infects North American woodchucks (Marmota monax). This virus is closely related to the human Hepatitis B virus (HBV), and it is used as a model for studying HBV infection and related liver diseases in woodchucks. The woodchuck hepatitis virus (WHV) can cause both acute and chronic hepatitis, liver fibrosis, cirrhosis, and liver cancer in its natural host. The virus-host interactions and the disease progression in woodchucks closely mimic those observed in humans with HBV infection. Therefore, studies of WHV infection in woodchucks have contributed significantly to our understanding of HBV biology, host immune responses, and the development of novel therapies for HBV infection in humans.

Viral DNA refers to the genetic material present in viruses that consist of DNA as their core component. Deoxyribonucleic acid (DNA) is one of the two types of nucleic acids that are responsible for storing and transmitting genetic information in living organisms. Viruses are infectious agents much smaller than bacteria that can only replicate inside the cells of other organisms, called hosts.

Viral DNA can be double-stranded (dsDNA) or single-stranded (ssDNA), depending on the type of virus. Double-stranded DNA viruses have a genome made up of two complementary strands of DNA, while single-stranded DNA viruses contain only one strand of DNA.

Examples of dsDNA viruses include Adenoviruses, Herpesviruses, and Poxviruses, while ssDNA viruses include Parvoviruses and Circoviruses. Viral DNA plays a crucial role in the replication cycle of the virus, encoding for various proteins necessary for its multiplication and survival within the host cell.

Cholera vaccines are preventive measures used to protect against the infection caused by the bacterium Vibrio cholerae. There are several types of cholera vaccines available, including:

1. Inactivated oral vaccine (ICCV): This vaccine contains killed whole-cell bacteria and is given in two doses, with each dose administered at least 14 days apart. It provides protection for up to six months and can be given to adults and children over the age of one year.
2. Live attenuated oral vaccine (LCV): This vaccine contains weakened live bacteria that are unable to cause disease but still stimulate an immune response. The most commonly used LCV is called CVD 103-HgR, which is given in a single dose and provides protection for up to three months. It can be given to adults and children over the age of six years.
3. Injectable cholera vaccine: This vaccine contains inactivated bacteria and is given as an injection. It is not widely available and its effectiveness is limited compared to oral vaccines.

Cholera vaccines are recommended for travelers visiting areas with known cholera outbreaks, particularly if they plan to eat food or drink water that may be contaminated. They can also be used in response to outbreaks to help control the spread of the disease. However, it is important to note that vaccination alone is not sufficient to prevent cholera infection and good hygiene practices, such as handwashing and safe food handling, should always be followed.

Hepatitis C antigens refer to the proteins present on the surface of the hepatitis C virus (HCV). The most commonly studied and clinically relevant antigen is the core protein, which plays a crucial role in the viral replication process. Detection of HCV antigens in serum or plasma can indicate an ongoing infection, as they appear during the early stages of infection and usually persist until the development of a humoral immune response, which leads to the production of antibodies against these antigens.

The detection of HCV core antigen (HCVcAg) has been used as an alternative diagnostic marker for HCV infection, especially in resource-limited settings where nucleic acid testing (NAT), such as polymerase chain reaction (PCR) for HCV RNA, might not be readily available. However, the sensitivity and specificity of HCVcAg detection are generally lower than those of NAT methods. Nonetheless, it remains a valuable tool in monitoring treatment response and disease progression in individuals with chronic hepatitis C infection.

An immunization schedule is a series of planned dates when a person, usually a child, should receive specific vaccines in order to be fully protected against certain preventable diseases. The schedule is developed based on scientific research and recommendations from health organizations such as the World Health Organization (WHO) and the Centers for Disease Control and Prevention (CDC).

The immunization schedule outlines which vaccines are recommended, the number of doses required, the age at which each dose should be given, and the minimum amount of time that must pass between doses. The schedule may vary depending on factors such as the individual's age, health status, and travel plans.

Immunization schedules are important for ensuring that individuals receive timely protection against vaccine-preventable diseases, and for maintaining high levels of immunity in populations, which helps to prevent the spread of disease. It is important to follow the recommended immunization schedule as closely as possible to ensure optimal protection.

Bilirubin is a yellowish pigment that is produced by the liver when it breaks down old red blood cells. It is a normal byproduct of hemoglobin metabolism and is usually conjugated (made water-soluble) in the liver before being excreted through the bile into the digestive system. Elevated levels of bilirubin can cause jaundice, a yellowing of the skin and eyes. Increased bilirubin levels may indicate liver disease or other medical conditions such as gallstones or hemolysis. It is also measured to assess liver function and to help diagnose various liver disorders.

Hepatic encephalopathy (HE) is a neuropsychiatric syndrome associated with liver dysfunction and/or portosystemic shunting. It results from the accumulation of toxic substances, such as ammonia and inflammatory mediators, which are normally metabolized by the liver. HE can present with a wide range of symptoms, including changes in sleep-wake cycle, altered mental status, confusion, disorientation, asterixis (flapping tremor), and in severe cases, coma. The diagnosis is based on clinical evaluation, neuropsychological testing, and exclusion of other causes of cognitive impairment. Treatment typically involves addressing the underlying liver dysfunction, reducing ammonia production through dietary modifications and medications, and preventing further episodes with lactulose or rifaximin therapy.

Prevalence, in medical terms, refers to the total number of people in a given population who have a particular disease or condition at a specific point in time, or over a specified period. It is typically expressed as a percentage or a ratio of the number of cases to the size of the population. Prevalence differs from incidence, which measures the number of new cases that develop during a certain period.

Chronic Hepatitis D is a liver infection caused by the hepatitis delta virus (HDV). It is often considered a serious form of hepatitis because it can lead to more severe liver disease than hepatitis B alone. HDV is a defective virus that requires the presence of hepatitis B surface antigen (HBsAg) to replicate and cause infection. Therefore, chronic hepatitis D only occurs in individuals who have an underlying chronic hepatitis B infection.

Chronic hepatitis D is characterized by persistent inflammation and damage to the liver, which can lead to scarring (fibrosis), cirrhosis, liver failure, and increased risk of liver cancer over time. Symptoms may include fatigue, joint pain, loss of appetite, nausea, vomiting, abdominal pain, dark urine, and jaundice. However, some people with chronic hepatitis D may not have any symptoms until the disease has progressed to a more advanced stage.

Chronic hepatitis D is diagnosed through blood tests that detect HDV antibodies and antigens, as well as liver function tests and imaging studies to assess liver damage. Treatment typically involves antiviral therapy to suppress the replication of both HBV and HDV, as well as supportive care to manage symptoms and prevent complications. In some cases, a liver transplant may be necessary for individuals with advanced liver disease due to chronic hepatitis D.

"Marmota" is a genus of large ground squirrels that are native to North America and Eurasia. These animals, also known as woodchucks or whistle pigs, are well-known for their ability to hibernate during the winter months. They typically live in burrows that they dig themselves, and their diet consists mainly of grasses, leaves, and shrubs. Marmotas are social creatures and often live in colonies with a dominant male and several females. While "Marmota" is a valid term in medical literature, it is more commonly found in the fields of biology and zoology rather than medicine.

Acute liver failure is a sudden and severe loss of liver function that occurs within a few days or weeks. It can be caused by various factors such as drug-induced liver injury, viral hepatitis, or metabolic disorders. In acute liver failure, the liver cannot perform its vital functions, including protein synthesis, detoxification, and metabolism of carbohydrates, fats, and proteins.

The symptoms of acute liver failure include jaundice (yellowing of the skin and eyes), coagulopathy (bleeding disorders), hepatic encephalopathy (neurological symptoms such as confusion, disorientation, and coma), and elevated levels of liver enzymes in the blood. Acute liver failure is a medical emergency that requires immediate hospitalization and treatment, which may include medications, supportive care, and liver transplantation.

Typhoid-Paratyphoid vaccines are immunizations that protect against typhoid fever and paratyphoid fevers, which are caused by the Salmonella enterica serovars Typhi and Paratyphi, respectively. These vaccines contain inactivated or attenuated bacteria or specific antigens that stimulate an individual's immune system to develop immunity against these diseases without causing the illness itself. There are several types of typhoid-paratyphoid vaccines available, including:

1. Ty21a (oral live attenuated vaccine): This is a live but weakened form of the Salmonella Typhi bacteria. It is given orally in capsule form and requires a series of 4 doses taken every other day. The vaccine provides protection for about 5-7 years.
2. Vi polysaccharide (ViPS) typhoid vaccine: This vaccine contains purified Vi antigens from the Salmonella Typhi bacterium's outer capsular layer. It is given as an injection and provides protection for approximately 2-3 years.
3. Combined typhoid-paratyphoid A and B vaccines (Vi-rEPA): This vaccine combines Vi polysaccharide antigens from Salmonella Typhi and Paratyphi A and B. It is given as an injection and provides protection for about 3 years against typhoid fever and paratyphoid fevers A and B.
4. Typhoid conjugate vaccines (TCVs): These vaccines combine the Vi polysaccharide antigen from Salmonella Typhi with a protein carrier to enhance the immune response, particularly in children under 2 years of age. TCVs are given as an injection and provide long-lasting protection against typhoid fever.

It is important to note that none of these vaccines provides 100% protection, but they significantly reduce the risk of contracting typhoid or paratyphoid fevers. Additionally, good hygiene practices, such as handwashing and safe food handling, can further minimize the risk of infection.

The Diphtheria-Tetanus-Pertussis (DTaP) vaccine is a combination immunization that protects against three bacterial diseases: diphtheria, tetanus (lockjaw), and pertussis (whooping cough).

Diphtheria is an upper respiratory infection that can lead to breathing difficulties, heart failure, paralysis, or even death. Tetanus is a bacterial infection that affects the nervous system and causes muscle stiffness and spasms, leading to "lockjaw." Pertussis is a highly contagious respiratory infection characterized by severe coughing fits, which can make it difficult to breathe and may lead to pneumonia, seizures, or brain damage.

The DTaP vaccine contains inactivated toxins (toxoids) from the bacteria that cause these diseases. It is typically given as a series of five shots, with doses administered at 2 months, 4 months, 6 months, 15-18 months, and 4-6 years of age. The vaccine helps the immune system develop protection against the diseases without causing the actual illness.

It is important to note that there are other combination vaccines available that protect against these same diseases, such as DT (diphtheria and tetanus toxoids) and Tdap (tetanus, diphtheria, and acellular pertussis), which contain higher doses of the diphtheria and pertussis components. These vaccines are recommended for different age groups and may be used as booster shots to maintain immunity throughout adulthood.

The Smallpox vaccine is not a live virus vaccine but is instead made from a vaccinia virus, which is a virus related to the variola virus (the virus that causes smallpox). The vaccinia virus used in the vaccine does not cause smallpox, but it does cause a milder illness with symptoms such as a fever and a rash of pustules or blisters at the site of inoculation.

The smallpox vaccine was first developed by Edward Jenner in 1796 and is one of the oldest vaccines still in use today. It has been highly effective in preventing smallpox, which was once a major cause of death and disability worldwide. In fact, smallpox was declared eradicated by the World Health Organization (WHO) in 1980, thanks in large part to the widespread use of the smallpox vaccine.

Despite the eradication of smallpox, the smallpox vaccine is still used today in certain circumstances. For example, it may be given to laboratory workers who handle the virus or to military personnel who may be at risk of exposure to the virus. The vaccine may also be used as an emergency measure in the event of a bioterrorism attack involving smallpox.

It is important to note that the smallpox vaccine is not without risks and can cause serious side effects, including a severe allergic reaction (anaphylaxis), encephalitis (inflammation of the brain), and myocarditis (inflammation of the heart muscle). As a result, it is only given to people who are at high risk of exposure to the virus and who have been determined to be good candidates for vaccination by a healthcare professional.

Molecular sequence data refers to the specific arrangement of molecules, most commonly nucleotides in DNA or RNA, or amino acids in proteins, that make up a biological macromolecule. This data is generated through laboratory techniques such as sequencing, and provides information about the exact order of the constituent molecules. This data is crucial in various fields of biology, including genetics, evolution, and molecular biology, allowing for comparisons between different organisms, identification of genetic variations, and studies of gene function and regulation.

Secondary immunization, also known as "anamnestic response" or "booster," refers to the enhanced immune response that occurs upon re-exposure to an antigen, having previously been immunized or infected with the same pathogen. This response is characterized by a more rapid and robust production of antibodies and memory cells compared to the primary immune response. The secondary immunization aims to maintain long-term immunity against infectious diseases and improve vaccine effectiveness. It usually involves administering additional doses of a vaccine or booster shots after the initial series of immunizations, which helps reinforce the immune system's ability to recognize and combat specific pathogens.

Drug-Induced Liver Injury (DILI) is a medical term that refers to liver damage or injury caused by the use of medications or drugs. This condition can vary in severity, from mild abnormalities in liver function tests to severe liver failure, which may require a liver transplant.

The exact mechanism of DILI can differ depending on the drug involved, but it generally occurs when the liver metabolizes the drug into toxic compounds that damage liver cells. This can happen through various pathways, including direct toxicity to liver cells, immune-mediated reactions, or metabolic idiosyncrasies.

Symptoms of DILI may include jaundice (yellowing of the skin and eyes), fatigue, abdominal pain, nausea, vomiting, loss of appetite, and dark urine. In severe cases, it can lead to complications such as ascites, encephalopathy, and bleeding disorders.

The diagnosis of DILI is often challenging because it requires the exclusion of other potential causes of liver injury. Liver function tests, imaging studies, and sometimes liver biopsies may be necessary to confirm the diagnosis. Treatment typically involves discontinuing the offending drug and providing supportive care until the liver recovers. In some cases, medications that protect the liver or promote its healing may be used.

A tuberculosis vaccine, also known as the BCG (Bacillus Calmette-Guérin) vaccine, is a type of immunization used to prevent tuberculosis (TB), a bacterial infection caused by Mycobacterium tuberculosis. The BCG vaccine contains a weakened strain of the bacteria that causes TB in cattle.

The BCG vaccine works by stimulating an immune response in the body, which helps to protect against severe forms of TB, such as TB meningitis and TB in children. However, it is not very effective at preventing pulmonary TB (TB that affects the lungs) in adults.

The BCG vaccine is not routinely recommended for use in the United States due to the low risk of TB infection in the general population. However, it may be given to people who are at high risk of exposure to TB, such as healthcare workers, laboratory personnel, and people traveling to countries with high rates of TB.

It is important to note that the BCG vaccine does not provide complete protection against TB and that other measures, such as testing and treatment for latent TB infection, are also important for controlling the spread of this disease.

The chickenpox vaccine, also known as varicella vaccine, is a preventive measure against the highly contagious viral infection caused by the varicella-zoster virus. The vaccine contains a live but weakened form of the virus, which stimulates the immune system to produce a response without causing the disease itself.

The chickenpox vaccine is typically given in two doses, with the first dose administered between 12 and 15 months of age and the second dose between 4 and 6 years of age. In some cases, the vaccine may be given to older children, adolescents, or adults who have not previously been vaccinated or who have never had chickenpox.

The chickenpox vaccine is highly effective at preventing severe cases of the disease and reducing the risk of complications such as bacterial infections, pneumonia, and encephalitis. It is also effective at preventing transmission of the virus to others.

Like any vaccine, the chickenpox vaccine can cause mild side effects such as soreness at the injection site, fever, or a mild rash. However, these side effects are generally mild and short-lived. Serious side effects are rare but may include allergic reactions or severe immune responses.

Overall, the chickenpox vaccine is a safe and effective way to prevent this common childhood disease and its potential complications.

Liver transplantation is a surgical procedure in which a diseased or failing liver is replaced with a healthy one from a deceased donor or, less commonly, a portion of a liver from a living donor. The goal of the procedure is to restore normal liver function and improve the patient's overall health and quality of life.

Liver transplantation may be recommended for individuals with end-stage liver disease, acute liver failure, certain genetic liver disorders, or liver cancers that cannot be treated effectively with other therapies. The procedure involves complex surgery to remove the diseased liver and implant the new one, followed by a period of recovery and close medical monitoring to ensure proper function and minimize the risk of complications.

The success of liver transplantation has improved significantly in recent years due to advances in surgical techniques, immunosuppressive medications, and post-transplant care. However, it remains a major operation with significant risks and challenges, including the need for lifelong immunosuppression to prevent rejection of the new liver, as well as potential complications such as infection, bleeding, and organ failure.

HIV (Human Immunodeficiency Virus) infection is a viral illness that progressively attacks and weakens the immune system, making individuals more susceptible to other infections and diseases. The virus primarily infects CD4+ T cells, a type of white blood cell essential for fighting off infections. Over time, as the number of these immune cells declines, the body becomes increasingly vulnerable to opportunistic infections and cancers.

HIV infection has three stages:

1. Acute HIV infection: This is the initial stage that occurs within 2-4 weeks after exposure to the virus. During this period, individuals may experience flu-like symptoms such as fever, fatigue, rash, swollen glands, and muscle aches. The virus replicates rapidly, and the viral load in the body is very high.
2. Chronic HIV infection (Clinical latency): This stage follows the acute infection and can last several years if left untreated. Although individuals may not show any symptoms during this phase, the virus continues to replicate at low levels, and the immune system gradually weakens. The viral load remains relatively stable, but the number of CD4+ T cells declines over time.
3. AIDS (Acquired Immunodeficiency Syndrome): This is the most advanced stage of HIV infection, characterized by a severely damaged immune system and numerous opportunistic infections or cancers. At this stage, the CD4+ T cell count drops below 200 cells/mm3 of blood.

It's important to note that with proper antiretroviral therapy (ART), individuals with HIV infection can effectively manage the virus, maintain a healthy immune system, and significantly reduce the risk of transmission to others. Early diagnosis and treatment are crucial for improving long-term health outcomes and reducing the spread of HIV.

Immunologic adjuvants are substances that are added to a vaccine to enhance the body's immune response to the antigens contained in the vaccine. They work by stimulating the immune system and promoting the production of antibodies and activating immune cells, such as T-cells and macrophages, which help to provide a stronger and more sustained immune response to the vaccine.

Immunologic adjuvants can be derived from various sources, including bacteria, viruses, and chemicals. Some common examples include aluminum salts (alum), oil-in-water emulsions (such as MF59), and bacterial components (such as lipopolysaccharide or LPS).

The use of immunologic adjuvants in vaccines can help to improve the efficacy of the vaccine, particularly for vaccines that contain weak or poorly immunogenic antigens. They can also help to reduce the amount of antigen needed in a vaccine, which can be beneficial for vaccines that are difficult or expensive to produce.

It's important to note that while adjuvants can enhance the immune response to a vaccine, they can also increase the risk of adverse reactions, such as inflammation and pain at the injection site. Therefore, the use of immunologic adjuvants must be carefully balanced against their potential benefits and risks.

The Mumps Vaccine is a biological preparation intended to induce immunity against mumps, a contagious viral infection that primarily affects the salivary glands. The vaccine contains live attenuated (weakened) mumps virus, which stimulates the immune system to develop a protective response without causing the disease.

There are two types of mumps vaccines available:

1. The Jeryl Lynn strain is used in the United States and is part of the Measles, Mumps, and Rubella (MMR) vaccine and the Measles, Mumps, Rubella, and Varicella (MMRV) vaccine. This strain is derived from a clinical isolate obtained from the throat washings of a child with mumps in 1963.
2. The Urabe AM9 strain was used in some countries but has been discontinued in many places due to an increased risk of meningitis as a rare complication.

The MMR vaccine is typically given to children at 12-15 months of age and again at 4-6 years of age, providing long-lasting immunity against mumps in most individuals. The vaccine has significantly reduced the incidence of mumps and its complications worldwide.

A chronic disease is a long-term medical condition that often progresses slowly over a period of years and requires ongoing management and care. These diseases are typically not fully curable, but symptoms can be managed to improve quality of life. Common chronic diseases include heart disease, stroke, cancer, diabetes, arthritis, and COPD (chronic obstructive pulmonary disease). They are often associated with advanced age, although they can also affect children and younger adults. Chronic diseases can have significant impacts on individuals' physical, emotional, and social well-being, as well as on healthcare systems and society at large.

Hepatitis A antigens refer to the proteins or molecules present on the surface of the Hepatitis A virus (HAV) that can stimulate an immune response in the body. There are two main types of HAV antigens:

1. Hepatitis A Virus Capsid Antigen (also known as HAV VP1): This is a structural protein that makes up the outer shell or capsid of the HAV particle. It contains several epitopes (regions that can be recognized by the immune system) that can induce the production of antibodies in infected individuals.
2. Hepatitis A Virus Non-structural Antigen (also known as HAV NS1): This is a non-structural protein produced during the replication of the HAV genome. It plays a crucial role in the replication and assembly of new HAV particles, but it is not present in the mature virion. However, its detection in serum or liver tissue can indicate an ongoing HAV infection.

The presence of antibodies against these antigens (anti-HAV antibodies) in a person's blood can be used to diagnose past or recent Hepatitis A infections and immunity acquired through vaccination.

Virus replication is the process by which a virus produces copies or reproduces itself inside a host cell. This involves several steps:

1. Attachment: The virus attaches to a specific receptor on the surface of the host cell.
2. Penetration: The viral genetic material enters the host cell, either by invagination of the cell membrane or endocytosis.
3. Uncoating: The viral genetic material is released from its protective coat (capsid) inside the host cell.
4. Replication: The viral genetic material uses the host cell's machinery to produce new viral components, such as proteins and nucleic acids.
5. Assembly: The newly synthesized viral components are assembled into new virus particles.
6. Release: The newly formed viruses are released from the host cell, often through lysis (breaking) of the cell membrane or by budding off the cell membrane.

The specific mechanisms and details of virus replication can vary depending on the type of virus. Some viruses, such as DNA viruses, use the host cell's DNA polymerase to replicate their genetic material, while others, such as RNA viruses, use their own RNA-dependent RNA polymerase or reverse transcriptase enzymes. Understanding the process of virus replication is important for developing antiviral therapies and vaccines.

Hepatitis antigens are proteins or molecules present on the surface or inside the hepatitis viruses (hepatitis A, B, C, D, and E) that can stimulate an immune response in the body. These antigens are targeted by the immune system to produce antibodies to fight against the infection.

For example, the Hepatitis B surface antigen (HBsAg) is a protein found on the surface of the hepatitis B virus and its presence in the blood indicates an ongoing infection or evidence of past infection/vaccination. Similarly, the core antigen (HBcAg) is a protein found inside the hepatitis B virus and is a marker of active viral replication.

Detection of these antigens in clinical samples such as blood is useful for diagnosing hepatitis infections and monitoring the effectiveness of treatment.

Hepatitis Delta Antigens (HDAg) are proteins found on the surface of the Hepatitis Delta Virus (HDV), a defective virus that requires the assistance of the Hepatitis B Virus (HBV) to replicate. There are two types of HDAg: small (S-HDAg) and large (L-HDAg). S-HDAg is a 195-amino acid protein that is essential for viral replication, while L-HDAg is a 214-amino acid protein that regulates the packaging of the viral genome into new virus particles. The presence of HDAg can be used to diagnose HDV infection and distinguish it from other forms of hepatitis.

Immunoglobulin G (IgG) is a type of antibody, which is a protective protein produced by the immune system in response to foreign substances like bacteria or viruses. IgG is the most abundant type of antibody in human blood, making up about 75-80% of all antibodies. It is found in all body fluids and plays a crucial role in fighting infections caused by bacteria, viruses, and toxins.

IgG has several important functions:

1. Neutralization: IgG can bind to the surface of bacteria or viruses, preventing them from attaching to and infecting human cells.
2. Opsonization: IgG coats the surface of pathogens, making them more recognizable and easier for immune cells like neutrophils and macrophages to phagocytose (engulf and destroy) them.
3. Complement activation: IgG can activate the complement system, a group of proteins that work together to help eliminate pathogens from the body. Activation of the complement system leads to the formation of the membrane attack complex, which creates holes in the cell membranes of bacteria, leading to their lysis (destruction).
4. Antibody-dependent cellular cytotoxicity (ADCC): IgG can bind to immune cells like natural killer (NK) cells and trigger them to release substances that cause target cells (such as virus-infected or cancerous cells) to undergo apoptosis (programmed cell death).
5. Immune complex formation: IgG can form immune complexes with antigens, which can then be removed from the body through various mechanisms, such as phagocytosis by immune cells or excretion in urine.

IgG is a critical component of adaptive immunity and provides long-lasting protection against reinfection with many pathogens. It has four subclasses (IgG1, IgG2, IgG3, and IgG4) that differ in their structure, function, and distribution in the body.

The Measles-Mumps-Rubella (MMR) vaccine is a combination immunization that protects against three infectious diseases: measles, mumps, and rubella. It contains live attenuated viruses of each disease, which stimulate an immune response in the body similar to that produced by natural infection but do not cause the diseases themselves.

The MMR vaccine is typically given in two doses, the first at 12-15 months of age and the second at 4-6 years of age. It is highly effective in preventing these diseases, with over 90% effectiveness reported after a single dose and near 100% effectiveness after the second dose.

Measles is a highly contagious viral disease that can cause fever, rash, cough, runny nose, and red, watery eyes. It can also lead to serious complications such as pneumonia, encephalitis (inflammation of the brain), and even death.

Mumps is a viral infection that primarily affects the salivary glands, causing swelling and tenderness in the cheeks and jaw. It can also cause fever, headache, muscle aches, and fatigue. Mumps can lead to serious complications such as deafness, meningitis (inflammation of the membranes surrounding the brain and spinal cord), and inflammation of the testicles or ovaries.

Rubella, also known as German measles, is a viral infection that typically causes a mild fever, rash, and swollen lymph nodes. However, if a pregnant woman becomes infected with rubella, it can cause serious birth defects such as hearing impairment, heart defects, and developmental delays in the fetus.

The MMR vaccine is an important tool in preventing these diseases and protecting public health.

A carrier state is a condition in which a person carries and may be able to transmit a genetic disorder or infectious disease, but does not show any symptoms of the disease themselves. This occurs when an individual has a recessive allele for a genetic disorder or is infected with a pathogen, but does not have the necessary combination of genes or other factors required to develop the full-blown disease.

For example, in the case of cystic fibrosis, which is caused by mutations in the CFTR gene, a person who carries one normal allele and one mutated allele for the disease is considered a carrier. They do not have symptoms of cystic fibrosis themselves, but they can pass the mutated allele on to their offspring, who may then develop the disease if they inherit the mutation from both parents.

Similarly, in the case of infectious diseases, a person who is infected with a pathogen but does not show any symptoms may still be able to transmit the infection to others. This is known as being an asymptomatic carrier or a healthy carrier. For example, some people who are infected with hepatitis B virus (HBV) may not develop any symptoms of liver disease, but they can still transmit the virus to others through contact with their blood or other bodily fluids.

It's important to note that in some cases, carriers of certain genetic disorders or infectious diseases may have mild or atypical symptoms that do not meet the full criteria for a diagnosis of the disease. In these cases, they may be considered to have a "reduced penetrance" or "incomplete expression" of the disorder or infection.

An Enzyme-Linked Immunosorbent Assay (ELISA) is a type of analytical biochemistry assay used to detect and quantify the presence of a substance, typically a protein or peptide, in a liquid sample. It takes its name from the enzyme-linked antibodies used in the assay.

In an ELISA, the sample is added to a well containing a surface that has been treated to capture the target substance. If the target substance is present in the sample, it will bind to the surface. Next, an enzyme-linked antibody specific to the target substance is added. This antibody will bind to the captured target substance if it is present. After washing away any unbound material, a substrate for the enzyme is added. If the enzyme is present due to its linkage to the antibody, it will catalyze a reaction that produces a detectable signal, such as a color change or fluorescence. The intensity of this signal is proportional to the amount of target substance present in the sample, allowing for quantification.

ELISAs are widely used in research and clinical settings to detect and measure various substances, including hormones, viruses, and bacteria. They offer high sensitivity, specificity, and reproducibility, making them a reliable choice for many applications.

Hepatocytes are the predominant type of cells in the liver, accounting for about 80% of its cytoplasmic mass. They play a key role in protein synthesis, protein storage, transformation of carbohydrates, synthesis of cholesterol, bile salts and phospholipids, detoxification, modification, and excretion of exogenous and endogenous substances, initiation of formation and secretion of bile, and enzyme production. Hepatocytes are essential for the maintenance of homeostasis in the body.

Medical Definition:

"Risk factors" are any attribute, characteristic or exposure of an individual that increases the likelihood of developing a disease or injury. They can be divided into modifiable and non-modifiable risk factors. Modifiable risk factors are those that can be changed through lifestyle choices or medical treatment, while non-modifiable risk factors are inherent traits such as age, gender, or genetic predisposition. Examples of modifiable risk factors include smoking, alcohol consumption, physical inactivity, and unhealthy diet, while non-modifiable risk factors include age, sex, and family history. It is important to note that having a risk factor does not guarantee that a person will develop the disease, but rather indicates an increased susceptibility.

I am not aware of any medical definition for the term "Egypt." Egypt is a country located in the northeastern corner of Africa, known for its rich history and cultural heritage. It is home to various ancient artifacts and monuments, including the Pyramids of Giza and the Sphinx.

If you have any specific medical or health-related questions related to Egypt, such as information about diseases prevalent in the country or healthcare practices there, I would be happy to try to help answer those for you.

Immunization is defined medically as the process where an individual is made immune or resistant to an infectious disease, typically through the administration of a vaccine. The vaccine stimulates the body's own immune system to recognize and fight off the specific disease-causing organism, thereby preventing or reducing the severity of future infections with that organism.

Immunization can be achieved actively, where the person is given a vaccine to trigger an immune response, or passively, where antibodies are transferred to the person through immunoglobulin therapy. Immunizations are an important part of preventive healthcare and have been successful in controlling and eliminating many infectious diseases worldwide.

Duck hepatitis B virus (DHBV) is not a medical definition related to human health, but it is a species of hepatitis B virus that primarily infects various species of ducks and other Anseriformes (waterfowl). It is closely related to the human hepatitis B virus (HBV), but it is not known to infect humans or other mammals.

DHBV, like HBV, is a DNA virus that targets the liver and can cause both acute and chronic infections. The virus is transmitted through the fecal-oral route and primarily affects young ducklings. Infection with DHBV can lead to liver damage and death in infected birds.

Researchers study DHBV as a model system for understanding HBV infection and pathogenesis, due to their similarities in viral structure, replication strategy, and host-virus interactions. However, it is important to note that DHBV is not a human health concern and does not pose a risk of infection to humans or other mammals.

Streptococcal vaccines are immunizations designed to protect against infections caused by Streptococcus bacteria. These vaccines contain antigens, which are substances that trigger an immune response and help the body recognize and fight off specific types of Streptococcus bacteria. There are several different types of streptococcal vaccines available or in development, including:

1. Pneumococcal conjugate vaccine (PCV): This vaccine protects against Streptococcus pneumoniae, a type of bacteria that can cause pneumonia, meningitis, and other serious infections. PCV is recommended for all children under 2 years old, as well as older children and adults with certain medical conditions.
2. Pneumococcal polysaccharide vaccine (PPSV): This vaccine also protects against Streptococcus pneumoniae, but it is recommended for adults 65 and older, as well as younger people with certain medical conditions.
3. Streptococcus pyogenes vaccine: This vaccine is being developed to protect against Group A Streptococcus (GAS), which can cause a variety of infections, including strep throat, skin infections, and serious diseases like rheumatic fever and toxic shock syndrome. There are several different GAS vaccine candidates in various stages of development.
4. Streptococcus agalactiae vaccine: This vaccine is being developed to protect against Group B Streptococcus (GBS), which can cause serious infections in newborns, pregnant women, and older adults with certain medical conditions. There are several different GBS vaccine candidates in various stages of development.

Overall, streptococcal vaccines play an important role in preventing bacterial infections and reducing the burden of disease caused by Streptococcus bacteria.

Lamivudine is an antiretroviral medication used in the treatment and management of HIV (Human Immunodeficiency Virus) infection and HBV (Hepatitis B Virus) infection. It is a nucleoside reverse transcriptase inhibitor (NRTI), which means it works by blocking the action of the reverse transcriptase enzyme that the viruses need to multiply. By doing this, Lamivudine helps to reduce the amount of the virus in the body, which in turn helps to slow down or prevent the damage that the virus can cause to the immune system and improve the patient's quality of life.

The medical definition of Lamivudine is: "A synthetic nucleoside analogue with activity against both HIV-1 and HBV. It is used in the treatment of HIV infection and AIDS, as well as chronic hepatitis B."

Viral nonstructural proteins (NS) are viral proteins that are not part of the virion structure. They play various roles in the viral life cycle, such as replication of the viral genome, transcription, translation regulation, and modulation of the host cell environment to favor virus replication. These proteins are often produced in large quantities during infection and can manipulate or disrupt various cellular pathways to benefit the virus. They may also be involved in evasion of the host's immune response. The specific functions of viral nonstructural proteins vary depending on the type of virus.

Viral load refers to the amount or quantity of virus (like HIV, Hepatitis C, SARS-CoV-2) present in an individual's blood or bodily fluids. It is often expressed as the number of virus copies per milliliter of blood or fluid. Monitoring viral load is important in managing and treating certain viral infections, as a higher viral load may indicate increased infectivity, disease progression, or response to treatment.

Anthrax vaccines are biological preparations designed to protect against anthrax, a potentially fatal infectious disease caused by the bacterium Bacillus anthracis. Anthrax can affect both humans and animals, and it is primarily transmitted through contact with contaminated animal products or, less commonly, through inhalation of spores.

There are two types of anthrax vaccines currently available:

1. Anthrax Vaccine Adsorbed (AVA): This vaccine is licensed for use in the United States and is approved for pre-exposure prophylaxis in high-risk individuals, such as military personnel and laboratory workers who handle the bacterium. AVA contains a cell-free filtrate of cultured B. anthracis cells that have been chemically treated to render them non-infectious. The vaccine works by stimulating the production of antibodies against protective antigens (PA) present in the bacterial culture.
2. Recombinant Anthrax Vaccine (rPA): This vaccine, also known as BioThrax, is a newer generation anthrax vaccine that was approved for use in the United States in 2015. It contains only the recombinant protective antigen (rPA) of B. anthracis, which is produced using genetic engineering techniques. The rPA vaccine has been shown to be as effective as AVA in generating an immune response and offers several advantages, including a more straightforward manufacturing process, fewer side effects, and a longer shelf life.

Both vaccines require multiple doses for initial immunization, followed by periodic booster shots to maintain protection. Anthrax vaccines are generally safe and effective at preventing anthrax infection; however, they may cause mild to moderate side effects, such as soreness at the injection site, fatigue, and muscle aches. Severe allergic reactions are rare but possible.

It is important to note that anthrax vaccines do not provide immediate protection against anthrax infection. They require several weeks to stimulate an immune response, so they should be administered before potential exposure to the bacterium. In cases of known or suspected exposure to anthrax, antibiotics are used as a primary means of preventing and treating the disease.

Alcoholic Liver Cirrhosis is a medical condition characterized by irreversible scarring (fibrosis) and damage to the liver caused by excessive consumption of alcohol over an extended period. The liver's normal structure and function are progressively impaired as healthy liver tissue is replaced by scarred tissue, leading to the formation of nodules (regenerative noduli).

The condition typically develops after years of heavy drinking, with a higher risk for those who consume more than 60 grams of pure alcohol daily. The damage caused by alcoholic liver cirrhosis can be life-threatening and may result in complications such as:

1. Ascites (accumulation of fluid in the abdomen)
2. Encephalopathy (neurological dysfunction due to liver failure)
3. Esophageal varices (dilated veins in the esophagus that can rupture and bleed)
4. Hepatorenal syndrome (kidney failure caused by liver disease)
5. Increased susceptibility to infections
6. Liver cancer (hepatocellular carcinoma)
7. Portal hypertension (increased blood pressure in the portal vein that supplies blood to the liver)

Abstaining from alcohol and managing underlying medical conditions are crucial for slowing down or halting disease progression. Treatment may involve medications, dietary changes, and supportive care to address complications. In severe cases, a liver transplant might be necessary.

A blood donor is a person who voluntarily gives their own blood or blood components to be used for the benefit of another person in need. The blood donation process involves collecting the donor's blood, testing it for infectious diseases, and then storing it until it is needed by a patient. There are several types of blood donations, including:

1. Whole blood donation: This is the most common type of blood donation, where a donor gives one unit (about 450-500 milliliters) of whole blood. The blood is then separated into its components (red cells, plasma, and platelets) for transfusion to patients with different needs.
2. Double red cell donation: In this type of donation, the donor's blood is collected using a special machine that separates two units of red cells from the whole blood. The remaining plasma and platelets are returned to the donor during the donation process. This type of donation can be done every 112 days.
3. Platelet donation: A donor's blood is collected using a special machine that separates platelets from the whole blood. The red cells and plasma are then returned to the donor during the donation process. This type of donation can be done every seven days, up to 24 times a year.
4. Plasma donation: A donor's blood is collected using a special machine that separates plasma from the whole blood. The red cells and platelets are then returned to the donor during the donation process. This type of donation can be done every 28 days, up to 13 times a year.

Blood donors must meet certain eligibility criteria, such as being in good health, aged between 18 and 65 (in some countries, the upper age limit may vary), and weighing over 50 kg (110 lbs). Donors are also required to answer medical questionnaires and undergo a mini-physical examination before each donation. The frequency of blood donations varies depending on the type of donation and the donor's health status.

Virosomes are artificially constructed spherical vesicles composed of lipids and viral envelope proteins. They are used as a delivery system for vaccines and other therapeutic agents. In the context of vaccines, virosomes can be used to present viral antigens to the immune system in a way that mimics a natural infection, thereby inducing a strong immune response.

Virosome-based vaccines have several advantages over traditional vaccines. For example, they are non-infectious, meaning they do not contain live or attenuated viruses, which makes them safer for certain populations such as immunocompromised individuals. Additionally, virosomes can be engineered to target specific cells in the body, leading to more efficient uptake and presentation of antigens to the immune system.

Virosome-based vaccines have been developed for a variety of diseases, including influenza, hepatitis A, and HIV. While they are not yet widely used, they show promise as a safe and effective alternative to traditional vaccine approaches.

Dengue vaccines are designed to protect against dengue fever, a mosquito-borne viral disease that can cause severe flu-like symptoms and potentially life-threatening complications. Dengue is caused by four distinct serotypes of the virus (DENV-1, DENV-2, DENV-3, and DENV-4), and infection with one serotype does not provide immunity against the others.

The first licensed dengue vaccine, Dengvaxia (CYD-TDV), is a chimeric yellow fever-dengue tetravalent vaccine developed by Sanofi Pasteur. It is approved for use in several countries and has demonstrated efficacy against dengue fever caused by all four serotypes in clinical trials. However, the vaccine has raised concerns about the risk of severe disease in individuals who have not been previously exposed to dengue. As a result, it is recommended primarily for people with a documented past dengue infection or living in areas with high dengue prevalence and where the benefits outweigh the risks.

Another dengue vaccine candidate, Takeda's TAK-003 (also known as TDV), is a live attenuated tetravalent dengue vaccine that has shown efficacy against all four serotypes in clinical trials. It was granted approval by the European Medicines Agency (EMA) and several other countries for use in individuals aged 4-16 years old, living in endemic areas.

Research and development of additional dengue vaccine candidates are ongoing to address concerns about safety, efficacy, and accessibility, particularly for at-risk populations in low- and middle-income countries where dengue is most prevalent.

Genotype, in genetics, refers to the complete heritable genetic makeup of an individual organism, including all of its genes. It is the set of instructions contained in an organism's DNA for the development and function of that organism. The genotype is the basis for an individual's inherited traits, and it can be contrasted with an individual's phenotype, which refers to the observable physical or biochemical characteristics of an organism that result from the expression of its genes in combination with environmental influences.

It is important to note that an individual's genotype is not necessarily identical to their genetic sequence. Some genes have multiple forms called alleles, and an individual may inherit different alleles for a given gene from each parent. The combination of alleles that an individual inherits for a particular gene is known as their genotype for that gene.

Understanding an individual's genotype can provide important information about their susceptibility to certain diseases, their response to drugs and other treatments, and their risk of passing on inherited genetic disorders to their offspring.

Recombinant proteins are artificially created proteins produced through the use of recombinant DNA technology. This process involves combining DNA molecules from different sources to create a new set of genes that encode for a specific protein. The resulting recombinant protein can then be expressed, purified, and used for various applications in research, medicine, and industry.

Recombinant proteins are widely used in biomedical research to study protein function, structure, and interactions. They are also used in the development of diagnostic tests, vaccines, and therapeutic drugs. For example, recombinant insulin is a common treatment for diabetes, while recombinant human growth hormone is used to treat growth disorders.

The production of recombinant proteins typically involves the use of host cells, such as bacteria, yeast, or mammalian cells, which are engineered to express the desired protein. The host cells are transformed with a plasmid vector containing the gene of interest, along with regulatory elements that control its expression. Once the host cells are cultured and the protein is expressed, it can be purified using various chromatography techniques.

Overall, recombinant proteins have revolutionized many areas of biology and medicine, enabling researchers to study and manipulate proteins in ways that were previously impossible.

Polyethylene glycols (PEGs) are a family of synthetic, water-soluble polymers with a wide range of molecular weights. They are commonly used in the medical field as excipients in pharmaceutical formulations due to their ability to improve drug solubility, stability, and bioavailability. PEGs can also be used as laxatives to treat constipation or as bowel cleansing agents prior to colonoscopy examinations. Additionally, some PEG-conjugated drugs have been developed for use in targeted cancer therapies.

In a medical context, PEGs are often referred to by their average molecular weight, such as PEG 300, PEG 400, PEG 1500, and so on. Higher molecular weight PEGs tend to be more viscous and have longer-lasting effects in the body.

It's worth noting that while PEGs are generally considered safe for use in medical applications, some people may experience allergic reactions or hypersensitivity to these compounds. Prolonged exposure to high molecular weight PEGs has also been linked to potential adverse effects, such as decreased fertility and developmental toxicity in animal studies. However, more research is needed to fully understand the long-term safety of PEGs in humans.

Liver failure is a serious condition in which the liver is no longer able to perform its normal functions, such as removing toxins and waste products from the blood, producing bile to help digest food, and regulating blood clotting. This can lead to a buildup of toxins in the body, jaundice (yellowing of the skin and eyes), fluid accumulation in the abdomen, and an increased risk of bleeding. Liver failure can be acute (sudden) or chronic (developing over time). Acute liver failure is often caused by medication toxicity, viral hepatitis, or other sudden illnesses. Chronic liver failure is most commonly caused by long-term damage from conditions such as cirrhosis, hepatitis, alcohol abuse, and non-alcoholic fatty liver disease.

It's important to note that Liver Failure is a life threatening condition and need immediate medical attention.

"Pan troglodytes" is the scientific name for a species of great apes known as the Common Chimpanzee. They are native to tropical rainforests in Western and Central Africa. Common Chimpanzees are our closest living relatives, sharing about 98.6% of our DNA. They are highly intelligent and social animals, capable of using tools, exhibiting complex behaviors, and displaying a range of emotions.

Here is a medical definition for 'Pan troglodytes':

The scientific name for the Common Chimpanzee species (genus Pan), a highly intelligent and social great ape native to tropical rainforests in Western and Central Africa. They are our closest living relatives, sharing approximately 98.6% of our DNA. Known for their complex behaviors, tool use, and emotional expression, Common Chimpanzees have been extensively studied in the fields of anthropology, psychology, and primatology to better understand human evolution and behavior.

BALB/c is an inbred strain of laboratory mouse that is widely used in biomedical research. The strain was developed at the Institute of Cancer Research in London by Henry Baldwin and his colleagues in the 1920s, and it has since become one of the most commonly used inbred strains in the world.

BALB/c mice are characterized by their black coat color, which is determined by a recessive allele at the tyrosinase locus. They are also known for their docile and friendly temperament, making them easy to handle and work with in the laboratory.

One of the key features of BALB/c mice that makes them useful for research is their susceptibility to certain types of tumors and immune responses. For example, they are highly susceptible to developing mammary tumors, which can be induced by chemical carcinogens or viral infection. They also have a strong Th2-biased immune response, which makes them useful models for studying allergic diseases and asthma.

BALB/c mice are also commonly used in studies of genetics, neuroscience, behavior, and infectious diseases. Because they are an inbred strain, they have a uniform genetic background, which makes it easier to control for genetic factors in experiments. Additionally, because they have been bred in the laboratory for many generations, they are highly standardized and reproducible, making them ideal subjects for scientific research.

Bacterial antibodies are a type of antibodies produced by the immune system in response to an infection caused by bacteria. These antibodies are proteins that recognize and bind to specific antigens on the surface of the bacterial cells, marking them for destruction by other immune cells. Bacterial antibodies can be classified into several types based on their structure and function, including IgG, IgM, IgA, and IgE. They play a crucial role in the body's defense against bacterial infections and provide immunity to future infections with the same bacteria.

Poliovirus Vaccine, Oral (OPV) is a vaccine used to prevent poliomyelitis (polio). It contains live attenuated (weakened) polioviruses, which stimulate an immune response in the body and provide protection against all three types of wild, infectious polioviruses. OPV is given by mouth, usually in drops, and it replicates in the gastrointestinal tract, where it induces a strong immune response. This response not only protects the individual who receives the vaccine but also helps to stop the spread of poliovirus in the community, providing indirect protection (herd immunity) to those who are not vaccinated. OPV is safe, effective, and easy to administer, making it an important tool for global polio eradication efforts. However, due to the risk of vaccine-associated paralytic polio (VAPP), inactivated poliovirus vaccine (IPV) is recommended for routine immunization in some countries.

Immunoglobulin M (IgM) is a type of antibody that is primarily found in the blood and lymph fluid. It is the first antibody to be produced in response to an initial exposure to an antigen, making it an important part of the body's primary immune response. IgM antibodies are large molecules that are composed of five basic units, giving them a pentameric structure. They are primarily found on the surface of B cells as membrane-bound immunoglobulins (mlgM), where they function as receptors for antigens. Once an mlgM receptor binds to an antigen, it triggers the activation and differentiation of the B cell into a plasma cell that produces and secretes large amounts of soluble IgM antibodies.

IgM antibodies are particularly effective at agglutination (clumping) and complement activation, which makes them important in the early stages of an immune response to help clear pathogens from the bloodstream. However, they are not as stable or long-lived as other types of antibodies, such as IgG, and their levels tend to decline after the initial immune response has occurred.

In summary, Immunoglobulin M (IgM) is a type of antibody that plays a crucial role in the primary immune response to antigens by agglutination and complement activation. It is primarily found in the blood and lymph fluid, and it is produced by B cells after they are activated by an antigen.

Retrospective studies, also known as retrospective research or looking back studies, are a type of observational study that examines data from the past to draw conclusions about possible causal relationships between risk factors and outcomes. In these studies, researchers analyze existing records, medical charts, or previously collected data to test a hypothesis or answer a specific research question.

Retrospective studies can be useful for generating hypotheses and identifying trends, but they have limitations compared to prospective studies, which follow participants forward in time from exposure to outcome. Retrospective studies are subject to biases such as recall bias, selection bias, and information bias, which can affect the validity of the results. Therefore, retrospective studies should be interpreted with caution and used primarily to generate hypotheses for further testing in prospective studies.

The Yellow Fever Vaccine is a vaccine that protects against the yellow fever virus, which is transmitted to humans through the bites of infected mosquitoes. The vaccine contains live, weakened yellow fever virus, and it works by stimulating the immune system to produce an immune response that provides protection against the disease.

The yellow fever vaccine is recommended for people who are traveling to areas where yellow fever is common, including parts of Africa and South America. It is also required for entry into some countries in these regions. The vaccine is generally safe and effective, but it can cause mild side effects such as headache, muscle pain, and fever in some people. Serious side effects are rare, but may include allergic reactions or infection with the weakened virus used in the vaccine.

It's important to note that yellow fever vaccine may not be recommended for certain individuals, including infants younger than 6 months, pregnant women, people with weakened immune systems, and those with a history of severe allergic reaction to a previous dose of the vaccine or any component of the vaccine. It is always best to consult with a healthcare provider before receiving any vaccination.

Serologic tests are laboratory tests that detect the presence or absence of antibodies or antigens in a patient's serum (the clear liquid that separates from clotted blood). These tests are commonly used to diagnose infectious diseases, as well as autoimmune disorders and other medical conditions.

In serologic testing for infectious diseases, a sample of the patient's blood is collected and allowed to clot. The serum is then separated from the clot and tested for the presence of antibodies that the body has produced in response to an infection. The test may be used to identify the specific type of infection or to determine whether the infection is active or has resolved.

Serologic tests can also be used to diagnose autoimmune disorders, such as rheumatoid arthritis and lupus, by detecting the presence of antibodies that are directed against the body's own tissues. These tests can help doctors confirm a diagnosis and monitor the progression of the disease.

It is important to note that serologic tests are not always 100% accurate and may produce false positive or false negative results. Therefore, they should be interpreted in conjunction with other clinical findings and laboratory test results.

In the field of medicine, "time factors" refer to the duration of symptoms or time elapsed since the onset of a medical condition, which can have significant implications for diagnosis and treatment. Understanding time factors is crucial in determining the progression of a disease, evaluating the effectiveness of treatments, and making critical decisions regarding patient care.

For example, in stroke management, "time is brain," meaning that rapid intervention within a specific time frame (usually within 4.5 hours) is essential to administering tissue plasminogen activator (tPA), a clot-busting drug that can minimize brain damage and improve patient outcomes. Similarly, in trauma care, the "golden hour" concept emphasizes the importance of providing definitive care within the first 60 minutes after injury to increase survival rates and reduce morbidity.

Time factors also play a role in monitoring the progression of chronic conditions like diabetes or heart disease, where regular follow-ups and assessments help determine appropriate treatment adjustments and prevent complications. In infectious diseases, time factors are crucial for initiating antibiotic therapy and identifying potential outbreaks to control their spread.

Overall, "time factors" encompass the significance of recognizing and acting promptly in various medical scenarios to optimize patient outcomes and provide effective care.

Immunization programs, also known as vaccination programs, are organized efforts to administer vaccines to populations or communities in order to protect individuals from vaccine-preventable diseases. These programs are typically implemented by public health agencies and involve the planning, coordination, and delivery of immunizations to ensure that a high percentage of people are protected against specific infectious diseases.

Immunization programs may target specific age groups, such as infants and young children, or populations at higher risk of certain diseases, such as travelers, healthcare workers, or individuals with weakened immune systems. The goals of immunization programs include controlling and eliminating vaccine-preventable diseases, reducing the morbidity and mortality associated with these diseases, and protecting vulnerable populations from outbreaks and epidemics.

Immunization programs may be delivered through a variety of settings, including healthcare facilities, schools, community centers, and mobile clinics. They often involve partnerships between government agencies, healthcare providers, non-governmental organizations, and communities to ensure that vaccines are accessible, affordable, and acceptable to the populations they serve. Effective immunization programs require strong leadership, adequate funding, robust data systems, and ongoing monitoring and evaluation to assess their impact and identify areas for improvement.

A plague vaccine is a type of immunization used to protect against the bacterial infection caused by Yersinia pestis, the causative agent of plague. The vaccine contains killed or weakened forms of the bacteria, which stimulate the immune system to produce antibodies and activate immune cells that can recognize and fight off the infection if the person is exposed to the bacteria in the future.

There are several types of plague vaccines available, including whole-cell killed vaccines, live attenuated vaccines, and subunit vaccines. The choice of vaccine depends on various factors, such as the target population, the route of exposure (e.g., respiratory or cutaneous), and the desired duration of immunity.

Plague vaccines have been used for many years to protect military personnel and individuals at high risk of exposure to plague, such as laboratory workers and people living in areas where plague is endemic. However, their use is not widespread, and they are not currently recommended for general use in the United States or other developed countries.

It's important to note that while plague vaccines can provide some protection against the disease, they are not 100% effective, and other measures such as antibiotics and insect control are also important for preventing and treating plague infections.

In epidemiology, the incidence of a disease is defined as the number of new cases of that disease within a specific population over a certain period of time. It is typically expressed as a rate, with the number of new cases in the numerator and the size of the population at risk in the denominator. Incidence provides information about the risk of developing a disease during a given time period and can be used to compare disease rates between different populations or to monitor trends in disease occurrence over time.

"West Germany" is not a medical term. It is a geopolitical term that refers to the Federal Republic of Germany (FRG) which existed from 1949 to 1990. The FRG was established in the western part of defeated Nazi Germany and was supported by the Western Allies (the United States, the United Kingdom, and France) after World War II.

In medical contexts, references to "West Germany" might appear in older studies or publications that compare health outcomes, disease prevalence, or healthcare systems between different regions or countries, including East and West Germany before reunification in 1990. However, it is essential to understand that such distinctions are historical and do not have current medical relevance.

A fungal vaccine is a biological preparation that provides active acquired immunity against fungal infections. It contains one or more fungal antigens, which are substances that can stimulate an immune response, along with adjuvants to enhance the immune response. The goal of fungal vaccines is to protect against invasive fungal diseases, especially in individuals with weakened immune systems, such as those undergoing chemotherapy, organ transplantation, or HIV/AIDS treatment.

Fungal vaccines can work by inducing both humoral and cell-mediated immunity. Humoral immunity involves the production of antibodies that recognize and neutralize fungal antigens, while cell-mediated immunity involves the activation of T cells to directly attack infected cells.

Currently, there are no licensed fungal vaccines available for human use, although several candidates are in various stages of development and clinical trials. Some examples include vaccines against Candida albicans, Aspergillus fumigatus, Cryptococcus neoformans, and Pneumocystis jirovecii.

I'm sorry for any confusion, but "India" is not a medical term or concept. It is a country in South Asia, the second-most populous country in the world, known for its rich history, diverse culture, and numerous contributions to various fields including medicine. If you have any questions related to medical topics, I would be happy to help answer them!

Treatment outcome is a term used to describe the result or effect of medical treatment on a patient's health status. It can be measured in various ways, such as through symptoms improvement, disease remission, reduced disability, improved quality of life, or survival rates. The treatment outcome helps healthcare providers evaluate the effectiveness of a particular treatment plan and make informed decisions about future care. It is also used in clinical research to compare the efficacy of different treatments and improve patient care.

Virus-like particles (VLPs) are nanostructures that mimic the organization and conformation of authentic viruses but lack the genetic material required for replication. VLPs can be produced from one or more viral proteins, which can be derived from various expression systems including bacteria, yeast, insect, or mammalian cells.

VLP-based vaccines are a type of vaccine that uses these virus-like particles to induce an immune response in the body. These vaccines can be designed to target specific viruses or other pathogens and have been shown to be safe and effective in inducing both humoral and cellular immunity.

VLPs resemble authentic viruses in their structure, size, and antigenic properties, making them highly immunogenic. They can be designed to present specific epitopes or antigens from a pathogen, which can stimulate the immune system to produce antibodies and activate T-cells that recognize and attack the pathogen.

VLP vaccines have been developed for several viruses, including human papillomavirus (HPV), hepatitis B virus (HBV), and respiratory syncytial virus (RSV). They offer several advantages over traditional vaccines, such as a strong immune response, safety, and stability.

A biopsy is a medical procedure in which a small sample of tissue is taken from the body to be examined under a microscope for the presence of disease. This can help doctors diagnose and monitor various medical conditions, such as cancer, infections, or autoimmune disorders. The type of biopsy performed will depend on the location and nature of the suspected condition. Some common types of biopsies include:

1. Incisional biopsy: In this procedure, a surgeon removes a piece of tissue from an abnormal area using a scalpel or other surgical instrument. This type of biopsy is often used when the lesion is too large to be removed entirely during the initial biopsy.

2. Excisional biopsy: An excisional biopsy involves removing the entire abnormal area, along with a margin of healthy tissue surrounding it. This technique is typically employed for smaller lesions or when cancer is suspected.

3. Needle biopsy: A needle biopsy uses a thin, hollow needle to extract cells or fluid from the body. There are two main types of needle biopsies: fine-needle aspiration (FNA) and core needle biopsy. FNA extracts loose cells, while a core needle biopsy removes a small piece of tissue.

4. Punch biopsy: In a punch biopsy, a round, sharp tool is used to remove a small cylindrical sample of skin tissue. This type of biopsy is often used for evaluating rashes or other skin abnormalities.

5. Shave biopsy: During a shave biopsy, a thin slice of tissue is removed from the surface of the skin using a sharp razor-like instrument. This technique is typically used for superficial lesions or growths on the skin.

After the biopsy sample has been collected, it is sent to a laboratory where a pathologist will examine the tissue under a microscope and provide a diagnosis based on their findings. The results of the biopsy can help guide further treatment decisions and determine the best course of action for managing the patient's condition.

Fatty liver, also known as hepatic steatosis, is a medical condition characterized by the abnormal accumulation of fat in the liver. The liver's primary function is to process nutrients, filter blood, and fight infections, among other tasks. When excess fat builds up in the liver cells, it can impair liver function and lead to inflammation, scarring, and even liver failure if left untreated.

Fatty liver can be caused by various factors, including alcohol consumption, obesity, nonalcoholic fatty liver disease (NAFLD), viral hepatitis, and certain medications or medical conditions. NAFLD is the most common cause of fatty liver in the United States and other developed countries, affecting up to 25% of the population.

Symptoms of fatty liver may include fatigue, weakness, weight loss, loss of appetite, nausea, abdominal pain or discomfort, and jaundice (yellowing of the skin and eyes). However, many people with fatty liver do not experience any symptoms, making it essential to diagnose and manage the condition through regular check-ups and blood tests.

Treatment for fatty liver depends on the underlying cause. Lifestyle changes such as weight loss, exercise, and dietary modifications are often recommended for people with NAFLD or alcohol-related fatty liver disease. Medications may also be prescribed to manage related conditions such as diabetes, high cholesterol, or metabolic syndrome. In severe cases of liver damage, a liver transplant may be necessary.

Rubella vaccine is a preventive measure used to immunize individuals against rubella, also known as German measles. It contains inactivated or weakened forms of the rubella virus that stimulate an immune response when introduced into the body. The two types of rubella vaccines available are:

1. Live Attenuated Rubella Vaccine (RAV): This vaccine contains a weakened form of the rubella virus, which triggers an immune response without causing the disease. It is the most commonly used rubella vaccine and is often combined with measles and mumps vaccines to create the Measles-Mumps-Rubella (MMR) or Measles-Mumps-Rubella-Varicella (MMRV) vaccines.

2. Inactivated Rubella Vaccine: This vaccine contains a killed rubella virus, which is less commonly used but can still provide immunity against the disease.

The Centers for Disease Control and Prevention (CDC) recommends that children receive one dose of MMR vaccine at 12-15 months of age and another dose at 4-6 years of age. This schedule ensures optimal protection against rubella and other diseases included in the vaccines.

It is important to note that pregnant women should not receive the rubella vaccine, as it can potentially harm the developing fetus. Women who are planning to become pregnant should ensure they have had their rubella immunization before conceiving.

Population surveillance in a public health and medical context refers to the ongoing, systematic collection, analysis, interpretation, and dissemination of health-related data for a defined population over time. It aims to monitor the health status, identify emerging health threats or trends, and evaluate the impact of interventions within that population. This information is used to inform public health policy, prioritize healthcare resources, and guide disease prevention and control efforts. Population surveillance can involve various data sources, such as vital records, disease registries, surveys, and electronic health records.

A base sequence in the context of molecular biology refers to the specific order of nucleotides in a DNA or RNA molecule. In DNA, these nucleotides are adenine (A), guanine (G), cytosine (C), and thymine (T). In RNA, uracil (U) takes the place of thymine. The base sequence contains genetic information that is transcribed into RNA and ultimately translated into proteins. It is the exact order of these bases that determines the genetic code and thus the function of the DNA or RNA molecule.

A biological marker, often referred to as a biomarker, is a measurable indicator that reflects the presence or severity of a disease state, or a response to a therapeutic intervention. Biomarkers can be found in various materials such as blood, tissues, or bodily fluids, and they can take many forms, including molecular, histologic, radiographic, or physiological measurements.

In the context of medical research and clinical practice, biomarkers are used for a variety of purposes, such as:

1. Diagnosis: Biomarkers can help diagnose a disease by indicating the presence or absence of a particular condition. For example, prostate-specific antigen (PSA) is a biomarker used to detect prostate cancer.
2. Monitoring: Biomarkers can be used to monitor the progression or regression of a disease over time. For instance, hemoglobin A1c (HbA1c) levels are monitored in diabetes patients to assess long-term blood glucose control.
3. Predicting: Biomarkers can help predict the likelihood of developing a particular disease or the risk of a negative outcome. For example, the presence of certain genetic mutations can indicate an increased risk for breast cancer.
4. Response to treatment: Biomarkers can be used to evaluate the effectiveness of a specific treatment by measuring changes in the biomarker levels before and after the intervention. This is particularly useful in personalized medicine, where treatments are tailored to individual patients based on their unique biomarker profiles.

It's important to note that for a biomarker to be considered clinically valid and useful, it must undergo rigorous validation through well-designed studies, including demonstrating sensitivity, specificity, reproducibility, and clinical relevance.

Viral core proteins are the structural proteins that make up the viral capsid or protein shell, enclosing and protecting the viral genome. These proteins play a crucial role in the assembly of the virion, assist in the infection process by helping to deliver the viral genome into the host cell, and may also have functions in regulating viral replication. The specific composition and structure of viral core proteins vary among different types of viruses.

Acellular vaccines are a type of vaccine that contain one or more antigens but do not contain whole cell parts or components of the pathogen. They are designed to produce an immune response in the body that is specific to the antigen(s) contained within the vaccine, while minimizing the risk of adverse reactions associated with whole cell vaccines.

Acellular vaccines are often produced using recombinant DNA technology, where a specific gene from the pathogen is inserted into a different organism (such as yeast or bacteria) that can produce large quantities of the antigen. The antigen is then purified and used to create the vaccine.

One example of an acellular vaccine is the DTaP vaccine, which is used to protect against diphtheria, tetanus, and pertussis (whooping cough). This vaccine contains only a small portion of the pertussis bacterium, along with purified versions of the toxins produced by the bacteria. By contrast, whole cell pertussis vaccines contain entire killed bacteria, which can cause more frequent and severe side effects.

Overall, acellular vaccines offer a safer and more targeted approach to immunization than whole cell vaccines, while still providing effective protection against infectious diseases.

An antigen is any substance that can stimulate an immune response, particularly the production of antibodies. Viral antigens are antigens that are found on or produced by viruses. They can be proteins, glycoproteins, or carbohydrates present on the surface or inside the viral particle.

Viral antigens play a crucial role in the immune system's recognition and response to viral infections. When a virus infects a host cell, it may display its antigens on the surface of the infected cell. This allows the immune system to recognize and target the infected cells for destruction, thereby limiting the spread of the virus.

Viral antigens are also important targets for vaccines. Vaccines typically work by introducing a harmless form of a viral antigen to the body, which then stimulates the production of antibodies and memory T-cells that can recognize and respond quickly and effectively to future infections with the actual virus.

It's worth noting that different types of viruses have different antigens, and these antigens can vary between strains of the same virus. This is why there are often different vaccines available for different viral diseases, and why flu vaccines need to be updated every year to account for changes in the circulating influenza virus strains.

A disease outbreak is defined as the occurrence of cases of a disease in excess of what would normally be expected in a given time and place. It may affect a small and localized group or a large number of people spread over a wide area, even internationally. An outbreak may be caused by a new agent, a change in the agent's virulence or host susceptibility, or an increase in the size or density of the host population.

Outbreaks can have significant public health and economic impacts, and require prompt investigation and control measures to prevent further spread of the disease. The investigation typically involves identifying the source of the outbreak, determining the mode of transmission, and implementing measures to interrupt the chain of infection. This may include vaccination, isolation or quarantine, and education of the public about the risks and prevention strategies.

Examples of disease outbreaks include foodborne illnesses linked to contaminated food or water, respiratory infections spread through coughing and sneezing, and mosquito-borne diseases such as Zika virus and West Nile virus. Outbreaks can also occur in healthcare settings, such as hospitals and nursing homes, where vulnerable populations may be at increased risk of infection.

I'm sorry for any confusion, but "United States" is a geopolitical entity, specifically the name of the country consisting of 50 states, and it is not a medical term or concept. Therefore, I can't provide a medical definition for it. If you have any questions related to health, medicine, or biology, I would be happy to try to help answer those!

Neutralizing antibodies are a type of antibody that defends against pathogens such as viruses or bacteria by neutralizing their ability to infect cells. They do this by binding to specific regions on the surface proteins of the pathogen, preventing it from attaching to and entering host cells. This renders the pathogen ineffective and helps to prevent or reduce the severity of infection. Neutralizing antibodies can be produced naturally in response to an infection or vaccination, or they can be generated artificially for therapeutic purposes.

I believe there may be a slight confusion in your question. AIDS is a condition caused by the human immunodeficiency virus (HIV) infection, and it weakens the immune system, making people more susceptible to other infections and diseases. There is no vaccine for AIDS itself. However, there are vaccines being developed and tested to prevent HIV infection, which would help prevent AIDS from developing.

SAIDS is not a medical term. If you meant to ask about "HIV vaccines," I can provide a definition:

An HIV vaccine aims to stimulate the immune system to produce an effective response against the human immunodeficiency virus (HIV). An effective HIV vaccine would ideally prevent the initial infection or significantly reduce viral replication and disease progression in infected individuals. Currently, no licensed HIV vaccines are available, but research is ongoing to develop a protective vaccine against HIV infection.

Salmonella vaccines are immunizations that are developed to protect against Salmonella infections, which are caused by bacteria of the Salmonella enterica species. These vaccines typically contain antigens or weakened forms of the Salmonella bacteria that stimulate an immune response in the body, enabling it to recognize and fight off future Salmonella infections.

There are two main types of Salmonella vaccines:

1. Live Attenuated Vaccines: These vaccines contain weakened (attenuated) forms of the Salmonella bacteria that can still replicate but at a much slower rate and with reduced virulence compared to the wild-type bacteria. Examples include Ty21a, a live oral typhoid vaccine, and χ 144, an experimental live oral vaccine against nontyphoidal Salmonella serovars.
2. Inactivated (Killed) Vaccines: These vaccines contain killed Salmonella bacteria or their components, such as proteins or polysaccharides. They cannot replicate and are generally considered safer than live attenuated vaccines. However, they may not stimulate as strong an immune response compared to live vaccines. An example is the Vi polysaccharide vaccine against typhoid fever.

Salmonella vaccines are primarily used for preventing Salmonella infections in humans and animals, particularly those that cause typhoid fever and nontyphoidal Salmonella (NTS) infections. Vaccination is an essential component of controlling Salmonella infections, especially in areas with poor sanitation and hygiene, where the risk of exposure to Salmonella bacteria is higher.

Polymerase Chain Reaction (PCR) is a laboratory technique used to amplify specific regions of DNA. It enables the production of thousands to millions of copies of a particular DNA sequence in a rapid and efficient manner, making it an essential tool in various fields such as molecular biology, medical diagnostics, forensic science, and research.

The PCR process involves repeated cycles of heating and cooling to separate the DNA strands, allow primers (short sequences of single-stranded DNA) to attach to the target regions, and extend these primers using an enzyme called Taq polymerase, resulting in the exponential amplification of the desired DNA segment.

In a medical context, PCR is often used for detecting and quantifying specific pathogens (viruses, bacteria, fungi, or parasites) in clinical samples, identifying genetic mutations or polymorphisms associated with diseases, monitoring disease progression, and evaluating treatment effectiveness.

"Intramuscular injections" refer to a medical procedure where a medication or vaccine is administered directly into the muscle tissue. This is typically done using a hypodermic needle and syringe, and the injection is usually given into one of the large muscles in the body, such as the deltoid (shoulder), vastus lateralis (thigh), or ventrogluteal (buttock) muscles.

Intramuscular injections are used for a variety of reasons, including to deliver medications that need to be absorbed slowly over time, to bypass stomach acid and improve absorption, or to ensure that the medication reaches the bloodstream quickly and directly. Common examples of medications delivered via intramuscular injection include certain vaccines, antibiotics, and pain relievers.

It is important to follow proper technique when administering intramuscular injections to minimize pain and reduce the risk of complications such as infection or injury to surrounding tissues. Proper site selection, needle length and gauge, and injection technique are all critical factors in ensuring a safe and effective intramuscular injection.

Ebola vaccines are medical products designed to confer immunity against the Ebola virus, a deadly pathogen that causes hemorrhagic fever. Several Ebola vaccine candidates have been developed and tested in clinical trials, with some showing promising results. The most advanced Ebola vaccine is rVSV-ZEBOV, which has been shown to be highly effective in preventing the disease in clinical trials. It uses a weakened version of the vesicular stomatitis virus (VSV) to deliver a protein from the Ebola virus surface, triggering an immune response that protects against infection. Other Ebola vaccine candidates use different approaches, such as delivering Ebola virus genes using a harmless adenovirus vector or using inactivated whole Ebola viruses. These vaccines are still in development and have not yet been approved for widespread use.

"Military medicine" is a specific branch of medical practice that deals with the diagnosis, treatment, and prevention of diseases and injuries in military populations. It encompasses the provision of healthcare services to military personnel, both in peacetime and during times of conflict or emergency situations. This may include providing care in combat zones, managing mass casualties, delivering preventive medicine programs, conducting medical research, and providing medical support during peacekeeping missions and humanitarian assistance efforts. Military medicine also places a strong emphasis on the development and use of specialized equipment, techniques, and protocols to ensure the best possible medical care for military personnel in challenging environments.

Influenza, also known as the flu, is a highly contagious viral infection that attacks the respiratory system of humans. It is caused by influenza viruses A, B, or C and is characterized by the sudden onset of fever, chills, headache, muscle pain, sore throat, cough, runny nose, and fatigue. Influenza can lead to complications such as pneumonia, bronchitis, and ear infections, and can be particularly dangerous for young children, older adults, pregnant women, and people with weakened immune systems or chronic medical conditions. The virus is spread through respiratory droplets produced when an infected person coughs, sneezes, or talks, and can also survive on surfaces for a period of time. Influenza viruses are constantly changing, which makes it necessary to get vaccinated annually to protect against the most recent and prevalent strains.

Alcoholic liver disease (ALD) is a term that encompasses a spectrum of liver disorders caused by excessive alcohol consumption. The three main stages of ALD are:

1. Fatty Liver: This is the earliest stage of ALD, characterized by the accumulation of fat droplets within liver cells (hepatocytes). It's often reversible with abstinence from alcohol.

2. Alcoholic Hepatitis: This is a more severe form of ALD, characterized by inflammation and damage to the liver cells. It can range from mild to severe, and severe cases can lead to liver failure. Symptoms may include jaundice, abdominal pain, and fever.

3. Cirrhosis: This is the most advanced stage of ALD, characterized by widespread scarring (fibrosis) and nodular transformation of the liver. It's irreversible and can lead to complications such as liver failure, portal hypertension, and increased risk of liver cancer.

The development and progression of ALD are influenced by various factors, including the amount and duration of alcohol consumption, genetic predisposition, nutritional status, and co-existing viral hepatitis or other liver diseases. Abstaining from alcohol is the most effective way to prevent and manage ALD.

Combination drug therapy is a treatment approach that involves the use of multiple medications with different mechanisms of action to achieve better therapeutic outcomes. This approach is often used in the management of complex medical conditions such as cancer, HIV/AIDS, and cardiovascular diseases. The goal of combination drug therapy is to improve efficacy, reduce the risk of drug resistance, decrease the likelihood of adverse effects, and enhance the overall quality of life for patients.

In combining drugs, healthcare providers aim to target various pathways involved in the disease process, which may help to:

1. Increase the effectiveness of treatment by attacking the disease from multiple angles.
2. Decrease the dosage of individual medications, reducing the risk and severity of side effects.
3. Slow down or prevent the development of drug resistance, a common problem in chronic diseases like HIV/AIDS and cancer.
4. Improve patient compliance by simplifying dosing schedules and reducing pill burden.

Examples of combination drug therapy include:

1. Antiretroviral therapy (ART) for HIV treatment, which typically involves three or more drugs from different classes to suppress viral replication and prevent the development of drug resistance.
2. Chemotherapy regimens for cancer treatment, where multiple cytotoxic agents are used to target various stages of the cell cycle and reduce the likelihood of tumor cells developing resistance.
3. Cardiovascular disease management, which may involve combining medications such as angiotensin-converting enzyme (ACE) inhibitors, beta-blockers, diuretics, and statins to control blood pressure, heart rate, fluid balance, and cholesterol levels.
4. Treatment of tuberculosis, which often involves a combination of several antibiotics to target different aspects of the bacterial life cycle and prevent the development of drug-resistant strains.

When prescribing combination drug therapy, healthcare providers must carefully consider factors such as potential drug interactions, dosing schedules, adverse effects, and contraindications to ensure safe and effective treatment. Regular monitoring of patients is essential to assess treatment response, manage side effects, and adjust the treatment plan as needed.

Diphtheria-Tetanus-acellular Pertussis (DTaP) vaccines are a type of combination vaccine that protect against three serious diseases caused by bacteria: diphtheria, tetanus, and pertussis (also known as whooping cough).

Diphtheria is a highly contagious respiratory infection that can cause breathing difficulties, heart failure, paralysis, and even death. Tetanus, also known as lockjaw, is a bacterial infection that affects the nervous system and causes muscle stiffness and spasms, which can be severe enough to cause broken bones or suffocation. Pertussis is a highly contagious respiratory infection that causes severe coughing fits, making it difficult to breathe, eat, or drink.

The "a" in DTaP stands for "acellular," which means that the pertussis component of the vaccine contains only parts of the bacteria, rather than the whole cells used in older vaccines. This reduces the risk of side effects associated with the whole-cell pertussis vaccine while still providing effective protection against the disease.

DTaP vaccines are typically given as a series of five shots, starting at 2 months of age and ending at 4-6 years of age. Booster doses may be recommended later in life to maintain immunity. DTaP vaccines are an essential part of routine childhood immunization schedules and have significantly reduced the incidence of these diseases worldwide.

A cell line is a culture of cells that are grown in a laboratory for use in research. These cells are usually taken from a single cell or group of cells, and they are able to divide and grow continuously in the lab. Cell lines can come from many different sources, including animals, plants, and humans. They are often used in scientific research to study cellular processes, disease mechanisms, and to test new drugs or treatments. Some common types of human cell lines include HeLa cells (which come from a cancer patient named Henrietta Lacks), HEK293 cells (which come from embryonic kidney cells), and HUVEC cells (which come from umbilical vein endothelial cells). It is important to note that cell lines are not the same as primary cells, which are cells that are taken directly from a living organism and have not been grown in the lab.

Viral envelope proteins are structural proteins found in the envelope that surrounds many types of viruses. These proteins play a crucial role in the virus's life cycle, including attachment to host cells, fusion with the cell membrane, and entry into the host cell. They are typically made up of glycoproteins and are often responsible for eliciting an immune response in the host organism. The exact structure and function of viral envelope proteins vary between different types of viruses.

Interferons (IFNs) are a group of signaling proteins made and released by host cells in response to the presence of pathogens such as viruses, bacteria, parasites, or tumor cells. They belong to the larger family of cytokines and are crucial for the innate immune system's defense against infections. Interferons exist in multiple forms, classified into three types: type I (alpha and beta), type II (gamma), and type III (lambda). These proteins play a significant role in modulating the immune response, inhibiting viral replication, regulating cell growth, and promoting apoptosis of infected cells. Interferons are used as therapeutic agents for various medical conditions, including certain viral infections, cancers, and autoimmune diseases.

A viral genome is the genetic material (DNA or RNA) that is present in a virus. It contains all the genetic information that a virus needs to replicate itself and infect its host. The size and complexity of viral genomes can vary greatly, ranging from a few thousand bases to hundreds of thousands of bases. Some viruses have linear genomes, while others have circular genomes. The genome of a virus also contains the information necessary for the virus to hijack the host cell's machinery and use it to produce new copies of the virus. Understanding the genetic makeup of viruses is important for developing vaccines and antiviral treatments.

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Randal J (June 1999). "Hepatitis C vaccine hampered by viral complexity, many technical restraints". Journal of the National ... Although vaccines exist for hepatitis A and hepatitis B, development of an HCV vaccine has presented challenges. No vaccine is ... A hepatitis C vaccine, a vaccine capable of protecting against the hepatitis C virus (HCV), is not yet available. ... Likely, vaccines following the first approved vaccine will address other genotypes by prevalence. VLP-based HCV vaccines are ...
"2011 Annual Surveillance Report of HIV, viral hepatitis, STIs". The Kirby Institute for Infection and Immunity. Sydney NSW: ... The vaccine is officially called the MEL-1 vaccine but also known as the MVA-E2 vaccine. In a study it has been suggested that ... vaccines are vaccines that prevent infection by certain types of human papillomavirus (HPV). Available HPV vaccines protect ... Vaccine. 33 (29): 3422-3428. doi:10.1016/j.vaccine.2015.04.014. PMID 25869893. "HPV Vaccine and Pregnancy". eMedTV. Archived ...
"Hepatitis B". www.who.int. Retrieved 2 December 2022. "Safety Information for Hepatitis B Vaccines , Vaccine Safety , CDC". www ... February 2017). "A novel hepatitis B virus subgenotype D10 circulating in Ethiopia". Journal of Viral Hepatitis. 24 (2): 163- ... Co-infection of hepatitis B and various other viruses can also occur. hepatitis C, hepatitis D (a satellite virus of hepatitis ... hepatitis B virus infection is easily avoided by receiving one of the hepatitis B vaccines. The plasma-derived HepB vaccine was ...
"Protection Against Viral Hepatitis Recommendations of the Immunization Practices Advisory Committee (ACIP)". www.cdc.gov. ... Yellow fever vaccine is a vaccine that protects against yellow fever. Yellow fever is a viral infection that occurs in Africa ... Only the 17D vaccine remains in use today. Theiler's vaccine was responsible for the largest outbreak of Hepatitis B in history ... Live vaccines, Vaccines, World Health Organization essential medicines (vaccines), Yellow fever, Wikipedia medicine articles ...
Kennedy, R.; Eichberg, J.; Lanford, R.; Dreesman, G. (1986). "Anti-idiotypic antibody vaccine for type B viral hepatitis in ... Kennedy has also helped to develop hepatitis B vaccines for chimpanzees and proposed their use in humans in a 1986 study. His ... Some of Kennedy's other research focused on the immune response to viral hepatitis. ... Kennedy was active in the search for an HIV vaccine for almost as long as the disease has existed. Kennedy has stated, "I first ...
Larkin M (June 24, 2020). "Adjuvanted viral-vectored vaccine promising against hepatitis C in early trial". Reuters Health News ... The Ii molecule-fused with a viral vector to a conserved region of the Hepatitis C virus (HCV) genome-has been tested as an ... June 2020). "MHC class II invariant chain-adjuvanted viral vectored vaccines enhances T cell responses in humans". Science ... This experimental vaccine was well-tolerated, and those who received the adjuvanted vaccine had stronger anti-HCV immune ...
... screening and control of viral hepatitis and its related diseases; Increasing hepatitis B vaccine coverage and integration into ... 2014: Hepatitis: Think Again 2015: Prevention of viral Hepatitis. Act now. 2016: Know Hepatitis-Act now. 2017: Eliminate ... Hepatitis. 2019: Invest in eliminating hepatitis. 2020: Hepatitis Free Future 2021: Hepatitis can't wait 2022: Bringing ... "World Hepatitis Alliance Calls on Governments to Take Urgent Action to Tackle Chronic Viral Hepatitis B & C Epidemic; 2008" ( ...
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Characterisation of immunogenetics of Hepatitis C viral clearance. Irish Society of Gastroenterology Irish Society for ... Vaccine development for H. pylori infection. Immunogenetics of gastrointestinal and liver disease. In 2004, he co-founded ... Development and patenting of H. pylori vaccine, which has been licensed to Chiron Corporation. ...
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A molecular biologist's view of viral hepatitis". Proceedings of the Royal Society. 230 (1259): 107-46. Bibcode:1987RSPSB.230.. ... Peptide vaccines: dream or reality?". Proceedings of the Royal Society. 344 (1308): 213-9. doi:10.1098/rstb.1994.0062. PMID ... 1985 Kenneth Murray, A molecular biologist's view of viral hepatitis 1984 William Duncan Paterson Stewart, The functional ... A prototype vaccine to prevent Epstein-Barr virus-associated tumours". Proceedings of the Royal Society. 221 (1222): 1-20. ...
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... hepatitis, or other chronic, viral infectious diseases with emotional, financial, and informational support. "April 2005 : ... Parents Possessing, Accessing and Communicating Knowledge about vaccines - Children's Hospital of Philadelphia". Archived from ... Green, William Finley; Hari Conjeevaram (2002). The First Year: Hepatitis B: An Essential Guide for the Newly Diagnosed. ... viral infectious diseases and educates the public on various methods of disease prevention. Founded in 1996 by a handful of ...
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... detectable hepatitis C viral RNA in Culex mosquitoes for up to 13 days. Currently, there are no specific vaccine therapies for ... There is a vaccine for yellow fever which was developed in the 1930s, the yellow 17D vaccine, and it is still in use today. The ... The viral RNA material will undergo several changes and processes inside the host's cell so that it can release more viral RNA ... The risk of complications from the vaccine are greater for individuals over 60 years of age. In addition, the vaccine is not ...
Funk E, Kottilil S, Gilliam B, Talwani R (May 2014). "Tickling the TLR7 to cure viral hepatitis". Journal of Translational ... "Inovio Goes It Alone on Hepatitis B Immunotherapy Vaccine as Roche Ends Collaboration". Genetic Engineering News. August 3, ... RG7795 (previously ANA773) is an antiviral drug candidate that as of 2015 had been in Phase II trials in hepatitis B. It is an ... From antiviral formulations to vaccine adjuvants". Advanced Drug Delivery Reviews. 175: 113803. doi:10.1016/j.addr.2021.05.013 ...
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Vaccination against hepatitis B protects against hepatitis D viral infection as hepatitis D requires hepatitis B viral ... The hepatitis B vaccine is routinely given soon after birth (usually within 24 hours) to protect against hepatitis B and D ... Hepatitis D is a type of viral hepatitis caused by the hepatitis delta virus (HDV). HDV is one of five known hepatitis viruses ... which is required for assembly of hepatitis D viral particles). Superinfections, in which hepatitis D viral infection occurs in ...
... also called canine hepatitis, is a DNA viral upper respiratory infection contracted through contact of a mucous membrane. ... The DA2PPC vaccine protects against the debilitating and deadly disease canine distemper. This disease is a fatal viral illness ... DA2PPC vaccine is a preventive measure against parvovirus, one of the most important diseases the vaccine protects a puppy ... This vaccine is usually given to puppies at 6-8 weeks of age, followed by 10-12 weeks of age, and then 14-16 weeks of age. This ...
The vaccine for hepatitis B protects against hepatitis D virus because of the latter's dependence on the presence of hepatitis ... There also have been scores of recorded cases of viral hepatitis caused by herpes simplex virus. Viral hepatitis is either ... Viral hepatitis is liver inflammation due to a viral infection. It may present in acute form as a recent infection with ... Effective treatments for hepatitis C are available but costly. In 2013, about 1.5 million people died from viral hepatitis, ...
A recombinant viral vector was first used when a hepatitis B surface antigen gene was inserted into a vaccinia virus. ... A viral vector vaccine is a vaccine that uses a viral vector to deliver genetic material (DNA) that can be transcribed by the ... As of April 2021[update], six viral vector vaccines, four COVID-19 vaccines and two Ebola vaccines, have been authorized for ... Travieso T, Li J, Mahesh S, Mello JD, Blasi M (July 2022). "The use of viral vectors in vaccine development". npj Vaccines. 7 ( ...
International AIDS Vaccine Initiative, French National Agency for Research on AIDS and Viral Hepatitis. In June 2003, a group ... The article asserted that current attempts to develop such a vaccine were insufficient and that a renewed HIV vaccine research ... Coordinating Committee of the Global HIV/AIDS Vaccine Enterprise (2005) The Global HIV/AIDS Vaccine Enterprise: Scientific ... 18 January 2005 Global HIV/AIDS Vaccine Enterprise (2005). "The Global HIV/AIDS Vaccine Enterprise: Scientific Strategic Plan ...
... dengue fever and viral hepatitis by using a proven safe vaccine virus, such as adenovirus, and modify its genome to have genes ... Another approach is to use vectors to create novel vaccines for diseases that have no vaccines available or the vaccines that ... Bull JJ, Smithson MW, Nuismer SL (January 2018). "Transmissible Viral Vaccines". Trends in Microbiology. 26 (1): 6-15. doi: ... Vaccine. 34 (50): 6436-6448. doi:10.1016/j.vaccine.2016.06.059. PMC 7115478. PMID 28029542. Gallagher, James (16 December 2012 ...
... disorders in practice Respiratory disease in practice Rheumatology in practice Thrombus Vaccines in practice Viral hepatitis in ...
MMR vaccines) and diphtheria, tetanus and pertussis (DTP) Viral Hepatitis Informatics is the science of using data, information ... Syphilis and Trichomoniasis Tuberculosis Vaccine preventable diseases, including measles, mumps and rubella ( ...
World Hepatitis Day occurs each year on July 28 to bring awareness to viral hepatitis. Early symptoms of Hepatitis A infection ... It is one of five known hepatitis viruses: A, B, C, D, and E. The hepatitis A vaccine is effective for prevention.[needs update ... Hepatitis A is an infectious disease of the liver caused by Hepatovirus A (HAV); it is a type of viral hepatitis. Many cases ... "Hepatitis A Vaccine: What you need to know" (PDF). Vaccine Information Statement. CDC. 2006-03-21. Archived (PDF) from the ...
... the first known hepatitis with a viral etiological agent was Hepatitis A, in the picornaviridae family. Hepatitis B Virus (HBV ... was identified as an infection distinct from Hepatitis A through its contamination of Yellow_fever_vaccine#History. The vaccine ... In replication, the viral pdsDNA is converted in the host cell nucleus to covalently-closed-circular DNA (cccDNA) by the viral ... Its best-known member is hepatitis B virus. Diseases associated with this family include: liver infections, such as hepatitis, ...
... and Other Vaccines for Oral Healthcare Personnel dental CE course & enrich your knowledge in oral healthcare field. Take course ... Learn about Hepatitis A Viral Infection from Mandated, Highly Recommended, ... Active Immunization: Hepatitis A Vaccine 4,6,20. There are two inactivated hepatitis A whole-virus vaccines (Vaqta, Havrix) and ... Hepatitis A Viral Infection. The hepatitis A virus (HAV) is primarily transmitted by the fecal-oral route, either by person-to- ...
Join us for an expert Q&A with NVHR Patient and Provider Advocates on the COVID-19 vaccine. ... Building COVID-19 Vaccine Confidence in the Viral Hepatitis Community. March 2, 2021 ... Panelists will share their experiences with the vaccine and ways theyre helping build vaccine confidence in their communities ... Hepatitis Education Project is a nonprofit that receives funding from a diversity of sources, including pharmaceutical ...
The hepatitis B virus (HBV), discovered in 1966, infects more than 350 million people worldwide. HBV can cause acute and ... Vaccines, Viral, Prevention. Class Summary. Hepatitis B vaccine is used for active immunization against disease caused by HBV. ... It inhibits hepatitis B viral DNA polymerase. It is indicated in patients with evidence of ongoing hepatitis B viral ... Hepatitis A vaccine, inactivated, and hepatitis B vaccine (Twinrix). *View full drug information ...
Vaccine in Adults. Advisory Committee on Immunization Practices. ... evidence for benefits and harms of the Hepatitis B (HepB) ... 2019 Viral Hepatitis Surveillance Report. 2021, Centers for Disease Control and Prevention. ... hepatitis b vaccine/ OR recombinant hepatitis B vaccine/ OR ((hepatitis B ADJ5 vaccin*) OR (HBV ADJ5 vaccin*) OR recombivax hb ... mh "Hepatitis B Vaccines"] OR (("hepatitis B" N5 vaccin*) OR (HBV N5 vaccin*) OR "recombivax hb" OR "engerix-b"):ti,ab AND ...
Hepatitis A virus seroprevalence by age and world region, 1990 and 2005. Vaccine. 2010;28:6653-7. DOIPubMedGoogle Scholar ... Divergent Genotype of Hepatitis A Virus in Alpacas Hepatitis C Virus Elimination among Inmates Rat Hepatitis E Virus in Norway ... hepatitis A virus (HAV), hepatitis B virus (HBV), and hepatitis C virus (HCV). Samples were tested for IgG against HEV, total ... of 347 persons with reported acute jaundice syndrome cases had hepatitis E, 14% had hepatitis B, and 5% had hepatitis C (5). ...
"Viral Hepatitis Vaccines" by people in this website by year, and whether "Viral Hepatitis Vaccines" was a major or minor topic ... "Viral Hepatitis Vaccines" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical ... Any vaccine raised against any virus or viral derivative that causes hepatitis. ... Viral Hepatitis Vaccines*Viral Hepatitis Vaccines. *Hepatitis Vaccines, Viral. *Vaccines, Viral Hepatitis ...
Acute Liver Failure Due to Herpes Simplex Viral Hepatitis. Journal of Medical Case Reports October 27, 2023 ... Effectiveness of COVID-19 mRNA Vaccines in Young Children. Morbidity & Mortality Weekly Report October 25, 2023 ...
Notice to Readers Licensure of Inactivated Hepatitis A Vaccine and Recommendations for Use Among International Travelers ... Additional information about hepatitis A vaccine is available from CDCs Hepatitis Branch, Division of Viral and Rickettsial ... Hepatitis A vaccine can be administered simultaneously with other vaccines and toxoids -- including hepatitis B, diphtheria, ... should be vaccinated with hepatitis A vaccine or receive IG before departure. Hepatitis A vaccine at the age-appropriate dose ...
Rabies is a viral disease that affects the central nervous system (CNS). The genus Lyssavirus contains more than 80 viruses. ... HRIG is not associated with transmission of viral hepatitis or HIV. Experimentally, infiltration of HRIG at the site of ... Two types of rabies vaccines have been produced: cell-cultured vaccines and nerve tissue vaccines. ... Rabies vaccine (HDCV, Imovax Rabies, Rabies vaccine human diploid cell culture). *View full drug information ...
Categories: Viral Hepatitis Vaccines Image Types: Photo, Illustrations, Video, Color, Black&White, PublicDomain, ...
Hepatitis B virus is a contagious liver infection spread from person-to-person via blood or body fluids. Who is at risk for HBV ... Prevention Tips for Hepatitis B (Hepatitis B Foundation) * Safety Information for Hepatitis B Vaccines (Centers for Disease ... What is hepatitis B?. Hepatitis B is a type of viral hepatitis. It can cause an acute (short-term) or chronic (long-term) ... FastStats: Viral Hepatitis (National Center for Health Statistics) * Viral Hepatitis Surveillance Report: United States, 2020 ( ...
Viral Hepatitis Everyone can be a flu vaccine advocate!. With the holidays quickly approaching, there will be more ... ABCs of Viral Hepatitis. Viral hepatitis is the term that describes inflammation of the liver that is caused by a virus. There ... Tags Hepatitis A, Hepatitis B, Liver Cancer, Liver Disease, Liver Failure, ... The most common types of viral hepatitis are A, B and C. These three Read More , ...
CDC Viral Hepatitis Updates. Archived Webinar - Hepatitis A and B Vaccines: Recommendations and Impact Webinar by the National ... CDC Viral Hepatitis Updates - Archived NFID Webinar on Hepatitis A & B Vaccines ... and evaluates the impact of vaccine implementation on the changing epidemiology of hepatitis A and hepatitis B diseases.. http ... People who are allergic to a component of hepatitis A vaccine These changes were made because of concerns about decreased HAV ...
Banatvala JE, Van Damme P. Hepatitis B vaccine---do we need boosters? J Viral Hepat 2003;10:1--6. * Bauer T, Jilg W. Hepatitis ... 1Division of Viral Hepatitis, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention (proposed) 2Immunization ... Hepatitis B Vaccine Hepatitis B vaccine is available as a single-antigen formulation and also in fixed combination with other ... Effects on HIV-1 viral load. Vaccine 2000; 18:1161--5. * Choudhury SA, Peters VB. Responses to hepatitis B vaccine boosters in ...
Overview of Acute Viral Hepatitis - Learn about the causes, symptoms, diagnosis & treatment from the MSD Manuals - Medical ... Routine vaccination with the hepatitis A vaccine Hepatitis A Vaccine The hepatitis A vaccine helps protect against hepatitis A ... read more and hepatitis B vaccine Hepatitis B Vaccine The hepatitis B vaccine helps protect against hepatitis B and its ... Causes of Acute Viral Hepatitis Acute viral hepatitis can be caused by five major hepatitis viruses (see table The Hepatitis ...
Influenza Surveillance Trends and Influenza Vaccine Effectiveness Among Department of Defense Beneficiaries During the 2019- ... Viral hepatitis C, active component, U.S. Armed Forces, 2011-2020. This study reports updated numbers and incidence rates of ... Vaccine. 2019;37:4015-4021.. *Shepard SS, Meno S, Bahl J, Wilson MM, Barnes J, Neuhaus E. Viral deep sequencing needs an ... To improve vaccine effectiveness (VE) against influenza viruses, the strains used in the influenza vaccine need to be updated ...
Inactivated hepatitis A virus produced in MRC-5 cells. Each adult dose contains 1440 ELISA units of viral antigen adsorbed on ... Hepatitis A and B vaccine is a vaccine against hepatitis A and hepatitis B. Hepatitis A and typhoid vaccine is a vaccine ... Hepatitis A vaccine is a vaccine that prevents hepatitis A. It is effective in around 95% of cases and lasts for at least ... "Hepatitis A Vaccine - an overview , ScienceDirect Topics". sciencedirect.com. Retrieved 14 February 2021. "Hepatitis A Vaccine ...
This study reports updated numbers and incidence rates of hepatitis C virus (HCV) infection among active component members of ... Commentary: The Role of Vaccines in Combatting the Potential "Tripledemic" of Influenza, COVID-19 and RSV. ... Hepatitis C virus (HCV) is the most common cause of chronic viral hepatitis in the United States.1 HCV can cause significant ... Viral hepatitis C, active component, U.S. Armed Forces, 2011-2020 The Armed Services Blood Program (ASBP) is the official blood ...
A special issue of Viruses (ISSN 1999-4915). This special issue belongs to the section "Viral Immunology, Vaccines, and ... relapsing hepatitis and possibly autoimmune hepatitis triggered by the viral infection. Less common manifestations of HEV ... Interests: viral hepatitis; liver tumors; non-alcoholic fatty liver disease; cirrhosis; liver transplantation. Special Issues, ... In Vivo Modelling of Hepatitis B Virus Subgenotype A1 Replication Using Adeno-Associated Viral Vectors by Shonisani Wendy ...
Vaccines, and Microbicides in Development July 2009 By Lei Chou, Mark Harrington, Bob Huff, Richard ... HIV, Tuberculosis, and Viral Hepatitis: Drugs, diagnostics, Vaccines, and Microbicides in Development. July 2009 ... viral hepatitis, and tuberculosis within the next few years. But in spotlighting what is in the pipeline, the report also ... very preliminary human studies of several new TB vaccine candidates, a back-to-basics mood in the HIV vaccine research ...
HIV, STI, & Viral Hepatitis Digest (November 22, 2023) HIV, STI, Viral Hepatitis, and Harm Reduction Digest: November 22, 2023 ... HIV, STI, & Viral Hepatitis HIV Marketing Webinar NACCHO and KFF continued their marketing and communications webinar series ... This opportunity is open to LHDs with an identified need or interest to promote vaccine confidence and contain vaccine ... and other vaccines. Selected LHDs will receive training, technical assistance, and other resources to address vaccine hesitancy ...
Hepatitis B virus, HCV: Hepatitis C virus, HIV/AIDS: Human immunodeficiency virus/acquired immune deficiency syndrome, HSC … ... activity against viral hepatitis C. ,b,Abbreviations Used,/b,: CB2: Cannabis receptor 2, CBD: Cannabidiol, DNA: ... While HBV has a vaccine, HCV has none at the moment. The risk of drug resistance, combined with the high cost of current ... Viral hepatitis B (HBV) and hepatitis C (HCV) pose a major health problem globally and if untreated, both viruses lead to ...
NEW WHO REPORT , Effective TB, HIV, Viral Hepatitis Services For Refugees And Migrants Across The WHO European Region. مارس 10 ... الرئيسية/أخبار/TIF Declares Support For Patent Waiver On COVID-19 Vaccines. أخبارTIF News (AR) TIF Declares Support For Patent ... COVID-19 Vaccines coronavirus globalcooperation LMICs PatentWaiver SaveHumanity VaccineAccess VaccinesForAll COVID-19 Pandemic ... A patent waiver, if agreed, would help countries with restricted access to COVID-19 vaccines so far, manufacture their own ...
... the most common types of viral hepatitis are hepatitis A, B, and C. Effective vaccines are available to help prevent hepatitis ... NHANES viral hepatitis data are used to monitor progress toward goals in Healthy People and the HHS Viral Hepatitis National ... and shipped to the Division of Viral Hepatitis, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers ... conditions until they were shipped to Division of Viral Hepatitis, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB ...
HIV, Viral Hepatitis and Sexually Transmissible Infections in Australia: Annual Surveillance Report 2018; Kirby Institute: UNSW ... human papillomavirus HPV; quadrivalent HPV vaccine; nonavalent HPV vaccine; 9-valent vaccine; genital warts; elimination; ... In 2018, the qHPV and nHPV vaccine together comprised ~77% of the total vaccine doses delivered globally [5]. ... two HPV vaccines, qHPV and nHPV, also provide protection against GW caused by low-risk HPV types 6/11. The choice of vaccine ...
  • It is approved to treat chronic hepatitis B infection in children aged 12 years or older who weigh at least 35 kg. (medscape.com)
  • Biologic interferons are proteins produced by host cells in response to viral infection. (medscape.com)
  • Ideally, candidates for interferon therapy have evidence of ongoing viral replication (presence of hepatitis e antigen [HBeAg] or HBV DNA) for at least 6 months and either persistently increased serum aminotransferase activity or evidence of chronic hepatitis B infection on liver biopsy findings. (medscape.com)
  • Clinical characterization of HEV infection is similar to that of other viral hepatitis infections, ranging from asymptomatic infection to fulminant hepatitis ( 2 ). (cdc.gov)
  • Unlike HAV and HEV, hepatitis B and C viruses (HBV and HCV) are transmitted through contact with infectious body fluids and can cause acute or chronic infection. (cdc.gov)
  • In February 1995, Havrix(R) * , an inactivated hepatitis A vaccine distributed by SmithKline Beecham Pharmaceuticals (Philadelphia, Pennsylvania) was licensed by the Food and Drug Administration for use in persons aged greater than or equal to 2 years to prevent hepatitis A virus (HAV) infection. (cdc.gov)
  • Prevaccination serologic testing may be indicated for adult travelers who probably have had prior HAV infection if the cost of testing is less than the cost of vaccination and if testing will not interfere with completion of the vaccine series. (cdc.gov)
  • Some people with acute hepatitis B have symptoms 2 to 5 months after infection. (medlineplus.gov)
  • But if you have a chronic infection and blood tests show that hepatitis B could be damaging your liver, you may need to take antiviral medicines. (medlineplus.gov)
  • Your provider may give you a dose of the hepatitis B vaccine to prevent infection. (medlineplus.gov)
  • Hepatitis B vaccination is the most effective measure to prevent hepatitis B virus (HBV) infection and its consequences, including cirrhosis of the liver, liver cancer, liver failure, and death. (cdc.gov)
  • This report, the second of a two-part statement from the Advisory Committee on Immunization Practices (ACIP), provides updated recommendations to increase hepatitis B vaccination of adults at risk for HBV infection. (cdc.gov)
  • In settings in which a high proportion of adults have risks for HBV infection (e.g., sexually transmitted disease/human immunodeficiency virus testing and treatment facilities, drug-abuse treatment and prevention settings, health-care settings targeting services to IDUs, health-care settings targeting services to MSM, and correctional facilities), ACIP recommends universal hepatitis B vaccination for all unvaccinated adults. (cdc.gov)
  • To promote vaccination in all settings, health-care providers should implement standing orders to identify adults recommended for hepatitis B vaccination and administer vaccination as part of routine clinical services, not require acknowledgment of an HBV infection risk factor for adults to receive vaccine, and use available reimbursement mechanisms to remove financial barriers to hepatitis B vaccination. (cdc.gov)
  • Acute viral hepatitis is inflammation of the liver, generally meaning inflammation caused by infection with one of the five hepatitis viruses. (msdmanuals.com)
  • Infection with both hepatitis B and D (called coinfection) may make the symptoms of hepatitis B even more severe. (msdmanuals.com)
  • On World Hepatitis Day, 28 July, WHO and partners will urge policy- makers, health workers and the pub- lic to act now to prevent infection and death from hepatitis. (who.int)
  • This study reports updated numbers and incidence rates of hepatitis C virus (HCV) infection among active component members of the U.S. military using a revised case definition during a 10-year surveillance period between 2011 and 2020. (health.mil)
  • NHANES testing for markers of infection with hepatitis viruses is used to determine secular trends in infection rates across most age and racial/ethnic groups and will provide a national picture of the epidemiologic determinants of these infections. (cdc.gov)
  • however, highly effective, well-tolerated treatment can cure hepatitis C virus infection. (cdc.gov)
  • Hepatitis D virus infection is less common in the US and can occur only among persons with hepatitis B virus infection. (cdc.gov)
  • Hepatitis E infection also is less common in the US. (cdc.gov)
  • Co-infection with hepatitis D virus (HDV) in persons with acute or chronic hepatitis B virus (HBV) infection can lead to fulminant hepatitis. (cdc.gov)
  • Hepatitis B surface antigen (HBsAg), derived from the viral envelope, is the first antigen to appear following infection and can be detected serologically as an aid in the laboratory diagnosis of acute HBV infection. (cdc.gov)
  • Hepatitis B is a viral liver infection that can lead to acute or chronic conditions. (pasteur.fr)
  • While the infection rate in urban areas of the country is estimated to be as high as 10%, as many as 40% of people living in rural Vietnam are infected with the hepatitis B virus. (killerinsideme.com)
  • The reason for this increased HBV infection is unknown, because hepatitis B has no clear transmission routes in many people in China, although both neonatal infection and horizontal transmission during early childhood are still the most common routes. (killerinsideme.com)
  • Symptoms of chronic hepatitis B can take up to 30 years to manifest, leaving most people unaware of their infection, and therefore may unknowingly be spread to others. (healthleadersmedia.com)
  • HEPLISAV-B is indicated for prevention of infection caused by all known subtypes of hepatitis B virus in adults 18 years of age and older. (healthleadersmedia.com)
  • HEPLISAV-B may not prevent hepatitis B infection in individuals who have an unrecognized hepatitis B infection at the time of vaccine administration. (healthleadersmedia.com)
  • The Hepatitis A virus (HAV) is spread by the fecal-oral route, meaning that the infection is spread when the feces from an infected person are somehow ingested by another person. (sequimgazette.com)
  • Chronic infection with Hepatitis A is rare. (sequimgazette.com)
  • Since Hepatitis A is spread by the fecal-oral route, eating food from safe sources will help prevent this infection. (sequimgazette.com)
  • Like Hepatitis A, Hepatitis B vaccine is the best way to prevent infection. (sequimgazette.com)
  • Because something can be done about HCV infection, knowing if you are infected with hepatitis C is important. (sequimgazette.com)
  • In the US, just 25% of adults are fully vaccinated against hepatitis B infection. (nvhr.org)
  • Chronic infection with viral hepatitis affects half a billion individuals worldwide and can lead to cirrhosis, cancer, and liver failure. (wjgnet.com)
  • This training includes an animated video with voiceover that covers the serologic tests for hepatitis A virus (HAV) infection, the serological diagnosis of HAV, the meanings of serologic markers, and interpret serologic test results. (cdc.gov)
  • The hepatitis B (HB) is a viral infection whose target tissue is the liver tissue and can cause acute and chronic illnesses (1). (researchsquare.com)
  • Hepatitis B viral infection presents a major global health concern and places a significant burden on the 257 million people living with the disease worldwide. (jnj.com)
  • 1 RNAi therapy candidates such as ARO-HBV have been shown to have an effect on hepatitis B viral infection replication pathways and on the production of viral proteins, providing another avenue for investigation into treatments in this area. (jnj.com)
  • Noele Nelson, MD, PhD, MPH, Medical Epidemiologist, Division of Viral Hepatitis, Centers for Disease Control and Prevention provides an update on the immunogenicity and safety of hepatitis A and B vaccines, explains current Advisory Committee on Immunization Practices (ACIP) recommendations, and evaluates the impact of vaccine implementation on the changing epidemiology of hepatitis A and hepatitis B diseases. (blogspot.com)
  • Interferon may prevent the progression of acute hepatitis to the chronic stage and may promote more rapid resolution of viremia and normalization of serum aminotransferase levels. (medscape.com)
  • In northern Uganda, surveillance of health care facilities during 2010-2012 showed that 42% of 347 persons with reported acute jaundice syndrome cases had hepatitis E, 14% had hepatitis B, and 5% had hepatitis C ( 5 ). (cdc.gov)
  • In rare cases, acute hepatitis B can cause liver failure. (medlineplus.gov)
  • If you have acute hepatitis B, you probably don't need treatment. (medlineplus.gov)
  • See also Overview of Acute Viral Hepatitis and Overview of Chronic Hepatitis. (msdmanuals.com)
  • Acute viral hepatitis is common throughout the world. (msdmanuals.com)
  • The hepatitis A virus is the most common cause of acute hepatitis, followed by the hepatitis B virus. (msdmanuals.com)
  • Other viruses can also cause acute viral hepatitis. (msdmanuals.com)
  • Hepatitis viruses constitute a major public health problem because of the morbidity and mortality associated with the acute and chronic consequences of these infections. (cdc.gov)
  • Viral hepatitis is a major public health problem of global importance because of the ongoing transmission of viruses that cause the disease and increased morbidity and mortality associated with the acute and chronic consequences of these infections. (cdc.gov)
  • This program led to a decline in the incidence of acute hepatitis B by ~80% between 1987 and 2004 4 and most individuals born after 1991 have been immunized against hepatitis B. Historically, the adult immunization strategy has been risk-based, focusing on those at highest risk of becoming infected. (healthleadersmedia.com)
  • The majority of hepatitis B infections are acute and clear up within 6 months. (rutgers.edu)
  • There is no treatment for acute hepatitis B, but symptoms can be alleviated by practicing healthy behaviors such as getting plenty of rest, water, and proper nutrition, and avoiding alcohol and other drugs. (rutgers.edu)
  • Chronic hepatitis B is often without symptoms, and occurs in about 5% of those infected with acute hepatitis B. Chronic hepatitis B infections can be complicated to manage, and care is usually referred to a liver or infectious disease specialist. (rutgers.edu)
  • The complete ACIP recommendations for the prevention of hepatitis A will be published. (cdc.gov)
  • With support from the Centers for Disease Control and Prevention (CDC), NACCHO is pleased to announce Equipping Local Health Departments to Address Vaccine Hesitancy , a technical assistance and capacity-building opportunity that will provide LHDs with resources to address vaccine hesitancy across the lifespan for routine, influenza, COVID-19, and other vaccines. (naccho.org)
  • The recent recommendation from the Centers for Disease Control and Prevention (CDC) expanding the number of adults who are recommended for immunization against hepatitis B is an important and bold step towards achieving the goal of elimination of hepatitis B. (healthleadersmedia.com)
  • Development of educational materials for hepatitis B/C prevention among high risk groups. (maine.gov)
  • Vol. 17.1 - Oct/2008 Lucca, Italy Prevention and control of viral hepatitis in Greece: Lessons learnt and the way forward . (vhpb.org)
  • Vol. 16.1 - Nov/2007 Ljubljana, Slovenia Prevention and control of viral hepatitis virus in Spain: Lessons learnt and the way forward . (vhpb.org)
  • Vol. 15.2 - Nov/2006 Madrid, Spain Prevention and control of perinatal hepatitis B virus transmission in the WHO European Region . (vhpb.org)
  • Vol. 14.1 - Nov/2005 Rome, Italy Prevention and control of viral hepatitis in France: lessons learnt and the way forward . (vhpb.org)
  • Vol. 13.1 - Mar/2004 Sevilla, Spain Prevention of viral hepatitis in Germany and the Nordic Countries: lessons learnt and the way forward . (vhpb.org)
  • This integrated approach to clinical practice and research on hepatitis prevention requires monitoring the traditional physiological and biomedical outcomes and improving the community environment, family support, and health related quality of life [ 7 , 8 ]. (biomedcentral.com)
  • The study monitored 33,413 hepatitis B patients for hepatocellular carcinoma (HCC) between 1997 and 2008 and tracked the number of HCC cases since 1999. (hepb.org)
  • The hepatitis C (HC) is the leading cause of chronic liver disease, leading to chronic hepatocellular carcinoma with a high economic burden (8-14). (researchsquare.com)
  • In addition, NHANES provides the means to better define the epidemiology of other hepatitis viruses. (cdc.gov)
  • Hepatitis B is caused by the hepatitis B virus. (medlineplus.gov)
  • Hepatitis B is a disease caused by the hepatitis B virus (HBV), which is transmitted through percutaneous (i.e., puncture through the skin) or mucosal (i.e., direct contact with mucous membranes) exposure to infectious blood or body fluids. (cdc.gov)
  • Jul compared to numbers ranging be- this analysis a strategy for Vaccine Preventable Diseases tween 5 and 18 before 2011. (who.int)
  • This Special Issue of the Viruses journal is dedicated to the diagnostic and therapeutic advancements of viral liver diseases with the aim of giving a complete update not only on the treatments currently available and future developments, but also on the still unmet needs in the management of special patient populations. (mdpi.com)
  • Vol. 5.3 - Jul/1997 Athens, Greece VHPB report on the IX Triennial International Symposium on Viral Hepatitis and Liver Diseases . (vhpb.org)
  • Earn free continuing education credits from the National Center for Immunization and Respiratory Diseases (NCIRD) Pink Book Web-on-Demand Series: Rotavirus and Hepatitis A. (cdc.gov)
  • However, in developed countries, the public's fear of vaccine-preventable diseases has waned, and awareness of potential adverse effects has increased, which is threatening vaccine acceptance. (nature.com)
  • To further the control of disease by vaccination, we must develop safe and effective new vaccines to combat infectious diseases, and address the public's concerns. (nature.com)
  • In the ensuing years, vaccines for more than 20 infectious diseases have been developed, and in 1977, Jenner's original experiment was brought to full fruition when smallpox was eradicated worldwide 6 . (nature.com)
  • Routine use of these vaccines has nearly eliminated meningitis and other diseases caused by H. influenzae type b 6 . (nature.com)
  • Vaccines are unique among medical interventions in that they are given to healthy individuals to prevent diseases that often do not pose an immediate threat to the recipient. (nature.com)
  • Hepatitis B (HB) and C (HC) are two severe infectious diseases with a high global health impact. (researchsquare.com)
  • Collecting a detailed travel history, particularly when signs and/or symptoms of gastrointestinal infections as mentioned above, mumps, varicella, tuberculosis, malaria, leishmaniasis, hepatitis A, and COVID-19 are present, may help in identifying and taking appropriate action to prevent further spread of these diseases within the United States. (cdc.gov)
  • This outcome is solely aimed at assessing the 2-dose Heplisav-B vaccine (approved in 2017). (cdc.gov)
  • In July 2017, the manufacturer of GamaSTAN S/D, also known as Immune Globulin (IG), updated dosing instructions for hepatitis A preexposure and postexposure prophylaxis. (blogspot.com)
  • NHANES viral hepatitis data are used to monitor progress toward goals in Healthy People and the HHS Viral Hepatitis National Strategic Plan , which in turn support US and global viral hepatitis elimination goals (HHS Healthy People, 2022 and NASEC, 2017). (cdc.gov)
  • Doctors blamed viral hepatitis for 5,611 deaths in 2017. (cbsnews.com)
  • Hepatitis A vaccination is recommended for adults with chronic liver disease, illicit drug users, and those at risk of healthcare-associated exposure. (dentalcare.com)
  • This agent is indicated for adults with HBeAg-positive and HBeAg-negative chronic hepatitis B with compensated liver disease and evidence of viral replication and liver inflammation. (medscape.com)
  • Should all hepatitis B (HepB)-unvaccinated adults receive HepB vaccination? (cdc.gov)
  • Immunogenicity studies have indicated that virtually 100% of children, adolescents, and adults develop protective levels of antibody to hepatitis A virus (anti-HAV) after completing the vaccine series (1,2). (cdc.gov)
  • Since everyone is at some risk, all adults should seriously consider getting the hepatitis B vaccine for a lifetime protection against a preventable chronic liver disease. (killerinsideme.com)
  • Many studies have shown that infants, children and adults who have responded to a complete hepatitis B immunisation. (killerinsideme.com)
  • The expansion of the current risk-based adult ACIP recommendation to include all adults 59 years of age and younger should help achieve the goal of hepatitis B elimination by 2030. (healthleadersmedia.com)
  • For adults to achieve the lifetime protection conferred by hepatitis B vaccines, they must achieve immune responses considered to be seroprotective. (healthleadersmedia.com)
  • For example, a study published in 2020 by Kaiser Permanente, showed only 26% of adults completed all three doses of the traditional hepatitis B vaccine. (healthleadersmedia.com)
  • In the Kaiser Permanente study, 45% of adults completed the two-dose vaccine series (almost twice as much as those with the three-dose series). (healthleadersmedia.com)
  • Hepatitis B vaccination is recommended for adults 60 years at increased risk of exposure to hepatitis B who were not vaccinated previously. (adam.com)
  • There are two inactivated hepatitis A whole-virus vaccines ( Vaqta, Havrix ) and a combination hepatitis A and B vaccine ( Twinrix ) available (Table 10). (dentalcare.com)
  • Within the U.S., the vaccine "Vaqta" developed by Maurice Hilleman and his team at Merck & Co. was licensed in 1995. (wikipedia.org)
  • Vaqta ( hepatitis a adult vaccine ) is a member of the viral vaccines drug class and is commonly used for Hepatitis A Prophylaxis. (drugs.com)
  • The Advisory Committee on Immunization Practices (ACIP) offers the following interim recommendations for the use of inactivated hepatitis A vaccine among international travelers. (cdc.gov)
  • A patent waiver, if agreed, would help countries with restricted access to COVID-19 vaccines so far, manufacture their own desperately-needed vaccines, inoculate their populations, and achieve, as such, immunization coverage targets. (thalassaemia.org.cy)
  • Hepatitis B would become the fifth vaccine routinely recommended for adult immunization (alongside Influenza, Tdap, Shingles and Pneumococcal). (healthleadersmedia.com)
  • When immune globulin (IG) is given concurrently with the first dose of vaccine, the proportion of persons who develop protective levels of anti-HAV is not affected, but antibody concentrations are lower. (cdc.gov)
  • In some cases, your provider may also give you a medicine called hepatitis B immune globulin (HBIG). (medlineplus.gov)
  • Common causes include hepatitis B and C viruses and certain drugs. (msdmanuals.com)
  • Engaging in certain activities, such as getting a tattoo or body piercing, sharing needles to inject drugs, or having multiple sex partners, increases the risk of developing hepatitis. (msdmanuals.com)
  • For those suffering from hepatitis B, in addition to a more refined diagnostic evaluation, several drugs with different therapeutic targets are being studied with the aim of a definitive cure. (mdpi.com)
  • Moreover, for delta hepatitis, we are finally on the road to being able to achieve the same goals as hepatitis B through the development of drugs that block viral replication with the hope that they can also be effective for a definitive recovery. (mdpi.com)
  • There is nothing as dramatic here as the bleak pessimism that enshrouded HIV vaccine research after the STEP study was prematurely terminated in 2007, nor the possibly overhyped HAART 2.0 breakthrough of that same year, when two new classes of anti-HIV drugs were introduced. (treatmentactiongroup.org)
  • People living with HIV who are on antiretroviral drugs should ensure they have at least a 30-day supply of these drugs, if not a 3- to 6-month supply and ensure that their vaccinations are up to date (influenza and pneumococcal vaccines). (iapac.org)
  • Anyone can get hepatitis A. Some people at high-risk include men who have sex with men, people who travel to countries where hepatitis A is common, and people who use street drugs (injected or non-injected). (nj.gov)
  • 20 The antiviral drugs amantadine and rimantadine are also effective against i= nfluenza A, but not influenza B.=20 Q3f.7 When is the influenza vaccine contraindicated? (faqs.org)
  • Where would we be without antibiotics, vaccines, new anti-HIV drugs? (healthyskepticism.org)
  • The estimated VE (46%) indicated that the influenza vaccine during the 2019-2020 influenza season was moderately effective against these influenza viruses. (health.mil)
  • The influenza vaccine was moderately effective against influenza viruses during the 2019-2020 influenza season. (health.mil)
  • To improve vaccine effectiveness (VE) against influenza viruses, the strains used in the influenza vaccine need to be updated regularly based on the surveillance findings. (health.mil)
  • Viral hepatitis B (HBV) and hepatitis C (HCV) pose a major health problem globally and if untreated, both viruses lead to severe liver damage resulting in liver cirrhosis and cancer. (nih.gov)
  • These five hepatitis viruses, also called hepatitides, are well-characterized for detection with laboratory assays and are monitored in U.S. public health surveillance systems. (cdc.gov)
  • Among the most common infectious causes of liver disease are the hepatitis viruses: Hepatitis A, Hepatitis B and Hepatitis C. (sequimgazette.com)
  • The vaccine is safe and effective and can be combined with Hepatitis A vaccine for life-long protection against both viruses. (sequimgazette.com)
  • Considering the importance of hepatitis B and C in this study, the prevalence of these viruses in people referring to the cohort of Guilan province will be discussed. (researchsquare.com)
  • Persons born during 1945-1965 account for approximately 75% of all hepatitis C virus (HCV) infections in the United States and 73% of HCV-associated mortality. (blogspot.com)
  • The MoPH, WHO and other UN agencies every year, mostly from hepatitis B analyzed the available are intensifying health promotion activities in and C. These infections can be pre- information on the hepa- terms of hygiene, provision of safe food and wa- vented, but most people don't know titis A incidence, patterns ter and sanitation. (who.int)
  • This new regional action framework was developed with the aim of achieving an African Region where the public health threats of HIV, tuberculosis, viral hepatitis and sexually transmitted infections are controlled or eliminated. (who.int)
  • People living with HIV who have not achieved viral suppression through antiretroviral therapy (ART) may have a compromised immune system that leaves them vulnerable to opportunistic infections and further disease progression. (iapac.org)
  • Vol. 14.2 - Apr/2006 Edinburgh, United Kingdom Hepatitis B, hepatitis C, and other blood-borne infections in healthcare workers . (vhpb.org)
  • Of particular interest to parents is a study published in Arch Pediatr Adolesc= Medicine, Oct 1995, 149:1113, in which children at high risk for otitis media (ear infections) showed 32% fewer cases during t= he flu season when they received the flu vaccine. (faqs.org)
  • 20 Note that influenza vaccine protects against influenza only, and not agains= t other respiratory infections. (faqs.org)
  • CDC expects the possibility of additional measles infections and spread among evacuees, based on ongoing transmission and low vaccine coverage (approximately 60%) in Afghanistan, and close living quarters during the process of evacuating people to the United States. (cdc.gov)
  • An important objective within Janssen is to develop highly effective combination products that cure people living with chronic hepatitis B infections," said Mathai Mammen, M.D., Ph.D., Global Head, Janssen Research & Development, LLC. (jnj.com)
  • People who are allergic to a component of hepatitis A vaccine These changes were made because of concerns about decreased HAV immunoglobulin G antibody (anti-HAV IgG) potency. (blogspot.com)
  • Hepatitis B core antibody (anti-HBc) is detectable shortly after the appearance of hepatitis B surface antigen (HBsAg). (cdc.gov)
  • His research interests include the study of immune responses against hepatitis c virus, particularly neutralizing antibody responses, with the goal of guiding vaccine development against the virus. (hopkinsmedicine.org)
  • Is it harmful to have an extra dose of hepatitis B vaccine or to repeat the entire hepatitis B vaccine series No, getting an extra dose of the hepatitis B vaccine is not harmful. (killerinsideme.com)
  • We've included a few key facts about the most common types of virial hepatitis found in the United States, and where to find testing centers and vaccine providers. (apiahf.org)
  • Based on a controlled clinical trial, the efficacy of two doses of vaccine (360 enzyme-linked immunosorbent assay units) administered 1 month apart in preventing hepatitis A in children was estimated to be 94% (95% confidence interval=79%-99%) (3). (cdc.gov)
  • The vaccine is given in the muscle of the upper arm, in two doses for the best protection. (wikipedia.org)
  • The pediatric (child) doses contain half the amount of viral antigen and aluminium. (wikipedia.org)
  • For HCP with normal immune status who have demonstrated adequate anti-HBs (≥10 mIU/mL) following full vaccination, booster doses of vaccine or periodic anti-HBs testing are not recommended. (killerinsideme.com)
  • Historically, adult hepatitis B vaccines required at least three doses administered over six-months and series completion has proven challenging. (healthleadersmedia.com)
  • Global and US goals have been established for elimination of viral hepatitis as a public health threat by 2030 (HHS Healthy People, 2022 and HHS 2020). (cdc.gov)
  • Context: In response to the first reported mpox cases in May 2022, the US government implemented plans to bring testing, treatment, and vaccines to communities disproportionately affected by mpox-including the population of men who have sex with men (MSM) and Black/African American and Hispanic/Latino men, 2 subpopulations experiencing vaccination disparities. (cdc.gov)
  • The definition of (U)nits varies among manufacturers depending on how hepatitis A antigen is measured in their products. (wikipedia.org)
  • Also sold under the brand names HAVpur and VIROHEP-A. This vaccine consists of virosomes, artificial particles composed of synthetic lipids and influenza proteins in addition to the hepatitis A antigen. (wikipedia.org)
  • Each adult dose contains 1440 ELISA units of viral antigen adsorbed on aluminium hydroxide (0.5 mg Al). (wikipedia.org)
  • Clinicians should also recommend the measles, mumps, and rubella (MMR) vaccine for unvaccinated patients. (cdc.gov)
  • Between 1990 and 2013, global viral hepatitis deaths increased from 0.89 million (95% uncertainty interval [UI] 0.86-0.94) to 1.45 million (1.38-1.54) (20). (researchsquare.com)
  • Hepatitis B is spread when blood, semen, or other body fluid infected with the hepatitis B virus enters the body of a person who is not infected. (adam.com)
  • During September 2019-October 2021, the ACIP Hepatitis Work Group held monthly conference calls to review and discuss scientific evidence relevant to the use of HepB vaccines in a universal adult vaccination recommendation. (cdc.gov)
  • The Work Group identified critical and important outcomes for inclusion in the GRADE tables, conducted a systematic review of the evidence, and subsequently reviewed and discussed findings and evidence quality ( www.cdc.gov/vaccines/acip/recs/index.html ) (3) (Table 1). (cdc.gov)
  • The 3-dose HepB vaccines have already been evaluated for their adverse events profiles and recommended by ACIP based on their safety records. (cdc.gov)
  • The expanded ACIP recommendation builds upon the highly-successful infant vaccination program for hepatitis B that was implemented in 1991. (healthleadersmedia.com)
  • In the midst of the raging COVID-19 pandemic, US President Joe Biden openly supported the World Trade Organization's (WTO) proposal to lift the proprietary limits on COVID-19 vaccines , in service of expanding distribution to poorer nations that are currently being battered by the pandemic. (thalassaemia.org.cy)
  • However, despite reductions in hepatitis B incidence achieved through incremental HepB vaccine policy over the past four decades, from a high of 26,654 reported cases (287,000 estimated) in 1985 to a low of 2,791 reported cases (19,200 estimated) in 2014, progress has stalled in further reducing hepatitis B incidence (1). (cdc.gov)
  • TAG's annual Pipeline Report surveys the developments in medicines and diagnostics most likely to improve the lives of people living with HIV, viral hepatitis, and tuberculosis within the next few years. (treatmentactiongroup.org)
  • Because of their underdeveloped immune systems, nearly all infants exposed to the virus will become chronic carriers of hepatitis B. (killerinsideme.com)
  • Most people born in Vietnam and other Asian countries who have Hepatitis B were infected as infants or young children. (killerinsideme.com)
  • Infants should get their first dose of hepatitis B vaccine at birth and will usually complete the series at 6-18 months of age. (adam.com)
  • The birth dose of hepatitis B vaccine is an important part of preventing long-term illness in infants and the spread of hepatitis B in the United States. (adam.com)
  • Twinrix contains the same hepatitis A component as Havrix , but half the dose. (dentalcare.com)
  • The hepatitis B vaccine provides immunity for at least 10 years and likely for a lifetime when completing the full series. (killerinsideme.com)
  • Advances in our understanding of the determinants of protective immunity and immunological memory, of the mechanisms by which adjuvants affect the quality and magnitude of immunological responses, and of microbial genomics, offer the promise for new and more effective vaccines in the near future. (nature.com)
  • 2019 Viral Hepatitis Surveillance Report. (cdc.gov)
  • Karen McKenzie of the Orange County, Florida Health Department prepares to administer the hepatitis A vaccine at an inoculation event on August 1, 2019. (cbsnews.com)
  • Given the importance of series completion at both the individual and population level, implementation considerations for universal hepatitis B vaccination should consider strategies to maximize adherence. (healthleadersmedia.com)
  • What are the symptoms of hepatitis B? (medlineplus.gov)
  • Often, people with hepatitis B don't have symptoms. (medlineplus.gov)
  • If you have chronic hepatitis B, you may not have symptoms until complications develop. (medlineplus.gov)
  • For this reason, hepatitis B screening is important, even if you have no symptoms. (medlineplus.gov)
  • Hepatitis A and C often cause very mild symptoms or none at all and may be unnoticed. (msdmanuals.com)
  • Hepatitis B and E are more likely to produce severe symptoms. (msdmanuals.com)
  • Chronic hepatitis B is dangerous because there are often no symptoms, and blood tests for liver enzymes may be normal. (killerinsideme.com)
  • Most people who go on to develop chronic hepatitis B do not have symptoms, but it is still very serious and can lead to liver damage (cirrhosis), liver cancer, and death. (adam.com)
  • Persons who are allergic to a vaccine component or otherwise elect not to receive vaccine should receive a single dose of IG (0.02 mL per kg of body weight), which provides effective protection against hepatitis A for up to 3 months. (cdc.gov)
  • As with any medicine, there is a very remote chance of a vaccine causing a severe allergic reaction, other serious injury, or death. (wikipedia.org)
  • Do not administer HEPLISAV-B to individuals with a history of severe allergic reaction (e.g., anaphylaxis) after a previous dose of any hepatitis B vaccine or to any component of HEPLISAV-B, including yeast. (healthleadersmedia.com)
  • Has had an allergic reaction after a previous dose of hepatitis B vaccine , or has any severe, life-threatening allergies. (adam.com)
  • Candidates among children include si= milar groups to those for pneumococcal vaccine: sickle cell, chronic renal and metabolic disease, diabetes, chronic pulmona= ry disease, long-term aspirin therapy, and significant cardiac disease (Catalana). (faqs.org)
  • Chronic hepatitis B can develop into a serious disease that causes long-term health problems such as cirrhosis (scarring of the liver), liver cancer , and liver failure. (medlineplus.gov)
  • One hundred times more infectious than HIV, 1 the hepatitis B virus (HBV) - which is the leading cause of cirrhosis and liver cancer - can be a silent killer. (healthleadersmedia.com)
  • Currently, there are an estimated 2.2 million people in the U.S. with chronic hepatitis B. 3 Despite tremendous progress towards eliminating this vaccine-preventable disease, the decline in hepatitis B rates has plateaued and more work is required to achieve the goal of hepatitis B elimination by 2030. (healthleadersmedia.com)
  • Efforts to optimize access and series completion, including choice of vaccine, will be critical to help achieve our common goal of eliminating this deadly disease. (healthleadersmedia.com)
  • Hepatitis B vaccine can prevent hepatitis B . Hepatitis B is a liver disease that can cause mild illness lasting a few weeks, or it can lead to a serious, lifelong illness. (adam.com)
  • Hepatitis B is a serious viral disease that harms the liver. (rutgers.edu)
  • Hepatitis A is a disease of the liver caused by a virus. (nj.gov)
  • The Family Burden Interview Schedule (FBIS) was primarily devised for the caregivers of schizophrenia patients, and the adverse effect of the disease was similar to the effect of chronic viral hepatitis on family caregivers. (biomedcentral.com)
  • Measles, also called Rubeola, is a highly contagious viral disease. (georgia.gov)
  • Soreness or redness where the shot is given, fever, headache, tiredness, or loss of appetite can happen after hepatitis A vaccine. (wikipedia.org)
  • Soreness where the shot is given or fever, headache, and fatigue (feeling tired) can happen after hepatitis B vaccination. (adam.com)
  • Protection against hepatitis A begins approximately two to four weeks after the initial vaccination. (wikipedia.org)
  • The duration of protection against hepatitis B is at least 15 years, with current scientific evidence also suggesting lifelong protection [17]. (killerinsideme.com)
  • Some people with chronic hepatitis B will need treatment. (medlineplus.gov)
  • The New Jersey Department of Health (NJDOH) Hepatitis Services Locator is an interactive directory for finding free or low cost publicly-funded hepatitis services, including vaccination, testing, and treatment. (nj.gov)
  • His primary clinical interest is management and treatment of viral hepatitis, including hepatitis c virus. (hopkinsmedicine.org)
  • Check this space for information about hepatitis elimination efforts in NJ. (nj.gov)
  • End-of-season influenza vaccine effectiveness (VE) was estimated using a test-negative case-control study design. (health.mil)
  • 20 Q3f.3 How effective is the influenza vaccine? (faqs.org)
  • 20 Q3f.4 How long does the influenza vaccine last? (faqs.org)
  • 20 Q3f.5 What are some of the risks of the influenza vaccine? (faqs.org)
  • 20 Q3f.6 When is the influenza vaccine recommended? (faqs.org)
  • While you're there, feel free to check out the page and see what Hep B Free Philadelphia's community-owned public health campaign is doing in Philadelphia to educate and raise public awareness, along with increasing testing and vaccination in the fight against hepatitis B and liver cancer. (hepb.org)
  • These are important findings because chronic hepatitis B significantly increases the risk of liver cance r, which causes 80% of primary liver cancers (HCC) worldwide. (hepb.org)
  • Vol. 13.2 - Mar/2005 Veyrier-du-Lac, France Hepatitis B vaccine: long-term efficacy, booster policy, and impact of HBV mutants on hepatitis B vaccination programmes . (vhpb.org)
  • 20 An intranasal flu vaccine has shown efficacy in trials and may be available= within a year. (faqs.org)
  • Hepatitis is inflammation of the liver . (medlineplus.gov)
  • Viral hepatitis is the term that describes inflammation of the liver that is caused by a virus. (cdc.gov)
  • Overview of Chronic Hepatitis Chronic hepatitis is inflammation of the liver that lasts at least 6 months. (msdmanuals.com)
  • Hepatitis is inflammation of the liver most often caused by a virus. (cdc.gov)
  • In developing countries worldwide, nerve tissue vaccines have been the most widely used type for prophylaxis of rabies. (medscape.com)
  • Apart from prescribing dosages, all other hepatitis A prophylaxis guidance remains the same. (blogspot.com)
  • Heat-treated and cold alcohol-fractionated immunoglobulin is derived from pooled human plasma from individuals immunized with human diploid cell rabies vaccine. (medscape.com)
  • Contacts who were not immune were given the MMR vaccine or, if not vaccine-eligible, immunoglobulin. (cdc.gov)
  • An estimated 300 million people worldwide are persistent carriers of hepatitis B virus (HBV). (cdc.gov)
  • The regional action frameworks for the implementation of global sector strategies respectively for HIV, viral hepatitis, STIs and the End TB strategy adopted at the Sixty-sixth and Sixty-seventh Regional Committees have triggered progress in national responses. (who.int)
  • The vaccine is licensed in adult and pediatric formulations, with different dosages and administration schedules Table 1 and should be administered by intramuscular injection into the deltoid muscle. (cdc.gov)
  • Hepatitis A vaccine can be administered simultaneously with other vaccines and toxoids -- including hepatitis B, diphtheria, tetanus, oral typhoid, cholera, Japanese encephalitis, rabies, and yellow fever -- without affecting immunogenicity or increasing the frequency of adverse events (5,6). (cdc.gov)
  • A few formulations combine hepatitis A with either hepatitis B or typhoid vaccine. (wikipedia.org)
  • These stimulated genes modulate inhibit viral replication in infected cells, cell proliferation, and immunomodulation. (medscape.com)
  • HRIG is not associated with transmission of viral hepatitis or HIV. (medscape.com)
  • Most Asians acquire hepatitis B as a consequence of vertical transmission from their mothers during birth or later in life via child-to-child transmission. (killerinsideme.com)
  • This should reduce hepatitis B transmission by making it easier to understand who should be immunized and increasing access to the vaccine. (healthleadersmedia.com)