Vincristine. Medical search

Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.

Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to form the active aldophosphamide. It has been used in the treatment of LYMPHOMA and LEUKEMIA. Its side effect, ALOPECIA, has been used for defleecing sheep. Cyclophosphamide may also cause sterility, birth defects, mutations, and cancer.

The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. The drugs need not be in the same dosage form.

A semisynthetic derivative of PODOPHYLLOTOXIN that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitotic phase of cell division, and lead to cell death. Etoposide acts primarily in the G2 and S phases of the cell cycle.

An alkylating agent of value against both hematologic malignancies and solid tumors.

A group of indole-indoline dimers which are ALKALOIDS obtained from the VINCA genus of plants. They inhibit polymerization of TUBULIN into MICROTUBULES thus blocking spindle formation and arresting cells in METAPHASE. They are some of the most useful ANTINEOPLASTIC AGENTS.

Agents obtained from higher plants that have demonstrable cytostatic or antineoplastic activity.

A complex of related glycopeptide antibiotics from Streptomyces verticillus consisting of bleomycin A2 and B2. It inhibits DNA metabolism and is used as an antineoplastic, especially for solid tumors.

Antitumor alkaloid isolated from Vinca rosea. (Merck, 11th ed.)

An antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of TETRAHYDROFOLATE DEHYDROGENASE and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA.

A 170-kDa transmembrane glycoprotein from the superfamily of ATP-BINDING CASSETTE TRANSPORTERS. It serves as an ATP-dependent efflux pump for a variety of chemicals, including many ANTINEOPLASTIC AGENTS. Overexpression of this glycoprotein is associated with multidrug resistance (see DRUG RESISTANCE, MULTIPLE).

Diminished or failed response of an organism, disease or tissue to the intended effectiveness of a chemical or drug. It should be differentiated from DRUG TOLERANCE which is the progressive diminution of the susceptibility of a human or animal to the effects of a drug, as a result of continued administration.

Antibodies obtained from a single clone of cells grown in mice or rats.

An experimental lymphocytic leukemia originally induced in DBA/2 mice by painting with methylcholanthrene.

Any of a group of malignant tumors of lymphoid tissue that differ from HODGKIN DISEASE, being more heterogeneous with respect to malignant cell lineage, clinical course, prognosis, and therapy. The only common feature among these tumors is the absence of giant REED-STERNBERG CELLS, a characteristic of Hodgkin's disease.

A hydrolase enzyme that converts L-asparagine and water to L-aspartate and NH3. EC 3.5.1.1.

Substances that inhibit or prevent the proliferation of NEOPLASMS.

The treatment of a disease or condition by several different means simultaneously or sequentially. Chemoimmunotherapy, RADIOIMMUNOTHERAPY, chemoradiotherapy, cryochemotherapy, and SALVAGE THERAPY are seen most frequently, but their combinations with each other and surgery are also used.

A very toxic anthracycline aminoglycoside antineoplastic isolated from Streptomyces peucetius and others, used in treatment of LEUKEMIA and other NEOPLASMS.

Simultaneous resistance to several structurally and functionally distinct drugs.

A glucocorticoid with the general properties of the corticosteroids. It is the drug of choice for all conditions in which routine systemic corticosteroid therapy is indicated, except adrenal deficiency states.

Malignant lymphoma composed of large B lymphoid cells whose nuclear size can exceed normal macrophage nuclei, or more than twice the size of a normal lymphocyte. The pattern is predominantly diffuse. Most of these lymphomas represent the malignant counterpart of B-lymphocytes at midstage in the process of differentiation.

A malignant solid tumor arising from mesenchymal tissues which normally differentiate to form striated muscle. It can occur in a wide variety of sites. It is divided into four distinct types: pleomorphic, predominantly in male adults; alveolar (RHABDOMYOSARCOMA, ALVEOLAR), mainly in adolescents and young adults; embryonal (RHABDOMYOSARCOMA, EMBRYONAL), predominantly in infants and children; and botryoidal, also in young children. It is one of the most frequently occurring soft tissue sarcomas and the most common in children under 15. (From Dorland, 27th ed; Holland et al., Cancer Medicine, 3d ed, p2186; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, pp1647-9)

Time schedule for administration of a drug in order to achieve optimum effectiveness and convenience.

Therapeutic act or process that initiates a response to a complete or partial remission level.

A pyrimidine nucleoside analog that is used mainly in the treatment of leukemia, especially acute non-lymphoblastic leukemia. Cytarabine is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA. Its actions are specific for the S phase of the cell cycle. It also has antiviral and immunosuppressant properties. (From Martindale, The Extra Pharmacopoeia, 30th ed, p472)

A neoplasm characterized by abnormalities of the lymphoid cell precursors leading to excessive lymphoblasts in the marrow and other organs. It is the most common cancer in children and accounts for the vast majority of all childhood leukemias.

A malignant disease characterized by progressive enlargement of the lymph nodes, spleen, and general lymphoid tissue. In the classical variant, giant usually multinucleate Hodgkin's and REED-STERNBERG CELLS are present; in the nodular lymphocyte predominant variant, lymphocytic and histiocytic cells are seen.

A compound composed of a two CYCLIC PEPTIDES attached to a phenoxazine that is derived from STREPTOMYCES parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also declines after dactinomycin therapy. (From AMA Drug Evaluations Annual, 1993, p2015)

An alkylating nitrogen mustard that is used as an antineoplastic in the form of the levo isomer - MELPHALAN, the racemic mixture - MERPHALAN, and the dextro isomer - MEDPHALAN; toxic to bone marrow, but little vesicant action; potential carcinogen.

Positional isomer of CYCLOPHOSPHAMIDE which is active as an alkylating agent and an immunosuppressive agent.

A relatively slow-growing glioma that is derived from oligodendrocytes and tends to occur in the cerebral hemispheres, thalamus, or lateral ventricle. They may present at any age, but are most frequent in the third to fifth decades, with an earlier incidence peak in the first decade. Histologically, these tumors are encapsulated, relatively avascular, and tend to form cysts and microcalcifications. Neoplastic cells tend to have small round nuclei surrounded by unstained nuclei. The tumors may vary from well-differentiated to highly anaplastic forms. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, p2052; Adams et al., Principles of Neurology, 6th ed, p655)

Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.

An anti-inflammatory 9-fluoro-glucocorticoid.

A calcium channel blocker that is a class IV anti-arrhythmia agent.

Period after successful treatment in which there is no appearance of the symptoms or effects of the disease.

An anaplastic, highly malignant, and usually bronchogenic carcinoma composed of small ovoid cells with scanty neoplasm. It is characterized by a dominant, deeply basophilic nucleus, and absent or indistinct nucleoli. (From Stedman, 25th ed; Holland et al., Cancer Medicine, 3d ed, p1286-7)

An antineoplastic agent. It has significant activity against melanomas. (from Martindale, The Extra Pharmacopoeia, 31st ed, p564)

Resistance or diminished response of a neoplasm to an antineoplastic agent in humans, animals, or cell or tissue cultures.

A plant genus of the family Apocynaceae. It is the source of VINCA ALKALOIDS, used in leukemia chemotherapy.

A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.

Vinblastine derivative with antineoplastic activity against CANCER. Major side effects are myelosuppression and neurotoxicity. Vindesine is used extensively in chemotherapy protocols (ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS).

Leukemia associated with HYPERPLASIA of the lymphoid tissues and increased numbers of circulating malignant LYMPHOCYTES and lymphoblasts.

An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle.

A semisynthetic derivative of PODOPHYLLOTOXIN that exhibits antitumor activity. Teniposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent cells from entering into the mitotic phase of the cell cycle, and lead to cell death. Teniposide acts primarily in the G2 and S phases of the cycle.

The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.

A major alkaloid from Colchicum autumnale L. and found also in other Colchicum species. Its primary therapeutic use is in the treatment of gout, but it has been used also in the therapy of familial Mediterranean fever (PERIODIC DISEASE).

4-Methyl derivative of LOMUSTINE; (CCNU). An antineoplastic agent which functions as an alkylating agent.

A lignan (LIGNANS) found in PODOPHYLLIN resin from the roots of PODOPHYLLUM plants. It is a potent spindle poison, toxic if taken internally, and has been used as a cathartic. It is very irritating to skin and mucous membranes, has keratolytic actions, has been used to treat warts and keratoses, and may have antineoplastic properties, as do some of its congeners and derivatives.

A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)

An anthracenedione-derived antineoplastic agent.

A malignant tumor of the bone which always arises in the medullary tissue, occurring more often in cylindrical bones. The tumor occurs usually before the age of 20, about twice as frequently in males as in females.

A malignancy of mature PLASMA CELLS engaging in monoclonal immunoglobulin production. It is characterized by hyperglobulinemia, excess Bence-Jones proteins (free monoclonal IMMUNOGLOBULIN LIGHT CHAINS) in the urine, skeletal destruction, bone pain, and fractures. Other features include ANEMIA; HYPERCALCEMIA; and RENAL INSUFFICIENCY.

A malignant kidney tumor, caused by the uncontrolled multiplication of renal stem (blastemal), stromal (STROMAL CELLS), and epithelial (EPITHELIAL CELLS) elements. However, not all three are present in every case. Several genes or chromosomal areas have been associated with Wilms tumor which is usually found in childhood as a firm lump in a child's side or ABDOMEN.

This line KB is now known to be a subline of the ubiquitous KERATIN-forming tumor cell line HeLa. It was originally thought to be derived from an epidermal carcinoma of the mouth, but was subsequently found, based on isoenzyme analysis, HeLa marker chromosomes, and DNA fingerprinting, to have been established via contamination by HELA CELLS. The cells are positive for keratin by immunoperoxidase staining. KB cells have been reported to contain human papillomavirus18 (HPV-18) sequences.

Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.

Chemical substances, produced by microorganisms, inhibiting or preventing the proliferation of neoplasms.

A sequence-related subfamily of ATP-BINDING CASSETTE TRANSPORTERS that actively transport organic substrates. Although considered organic anion transporters, a subset of proteins in this family have also been shown to convey drug resistance to neutral organic drugs. Their cellular function may have clinical significance for CHEMOTHERAPY in that they transport a variety of ANTINEOPLASTIC AGENTS. Overexpression of proteins in this class by NEOPLASMS is considered a possible mechanism in the development of multidrug resistance (DRUG RESISTANCE, MULTIPLE). Although similar in function to P-GLYCOPROTEINS, the proteins in this class share little sequence homology to the p-glycoprotein family of proteins.

Antineoplastic agent especially effective against malignant brain tumors. The resistance which brain tumor cells acquire to the initial effectiveness of this drug can be partially overcome by the simultaneous use of membrane-modifying agents such as reserpine, calcium antagonists such as nicardipine or verapamil, or the calmodulin inhibitor, trifluoperazine. The drug has also been used in combination with other antineoplastic agents or with radiotherapy for the treatment of various neoplasms.

A cell-cycle phase nonspecific alkylating antineoplastic agent. It is used in the treatment of brain tumors and various other malignant neoplasms. (From Martindale, The Extra Pharmacopoeia, 30th ed, p462) This substance may reasonably be anticipated to be a carcinogen according to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (From Merck Index, 11th ed)

Malignant lymphoma in which the lymphomatous cells are clustered into identifiable nodules within the LYMPH NODES. The nodules resemble to some extent the GERMINAL CENTER of lymph node follicles and most likely represent neoplastic proliferation of lymph node-derived follicular center B-LYMPHOCYTES.

Methods of investigating the effectiveness of anticancer cytotoxic drugs and biologic inhibitors. These include in vitro cell-kill models and cytostatic dye exclusion tests as well as in vivo measurement of tumor growth parameters in laboratory animals.

The relationship between the dose of an administered drug and the response of the organism to the drug.

Methods which attempt to express in replicable terms the extent of the neoplasm in the patient.

The action of a drug in promoting or enhancing the effectiveness of another drug.

Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.

A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.

Diseases of the peripheral nerves external to the brain and spinal cord, which includes diseases of the nerve roots, ganglia, plexi, autonomic nerves, sensory nerves, and motor nerves.

A group of heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes.

A general term for various neoplastic diseases of the lymphoid tissue.

Artificial, single or multilaminar vesicles (made from lecithins or other lipids) that are used for the delivery of a variety of biological molecules or molecular complexes to cells, for example, drug delivery and gene transfer. They are also used to study membranes and membrane proteins.

The span of viability of a cell characterized by the capacity to perform certain functions such as metabolism, growth, reproduction, some form of responsiveness, and adaptability.

A malignant neoplasm that may be classified either as a glioma or as a primitive neuroectodermal tumor of childhood (see NEUROECTODERMAL TUMOR, PRIMITIVE). The tumor occurs most frequently in the first decade of life with the most typical location being the cerebellar vermis. Histologic features include a high degree of cellularity, frequent mitotic figures, and a tendency for the cells to organize into sheets or form rosettes. Medulloblastoma have a high propensity to spread throughout the craniospinal intradural axis. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2060-1)

Agents that arrest cells in MITOSIS, most notably TUBULIN MODULATORS.

A cyclodecane isolated from the bark of the Pacific yew tree, TAXUS BREVIFOLIA. It stabilizes MICROTUBULES in their polymerized form leading to cell death.

Elements of limited time intervals, contributing to particular results or situations.

An antimetabolite antineoplastic agent with immunosuppressant properties. It interferes with nucleic acid synthesis by inhibiting purine metabolism and is used, usually in combination with other drugs, in the treatment of or in remission maintenance programs for leukemia.

A sulfhydryl compound used to prevent urothelial toxicity by inactivating metabolites from ANTINEOPLASTIC AGENTS, such as IFOSFAMIDE or CYCLOPHOSPHAMIDE.

Neoplasms of the brain and spinal cord derived from glial cells which vary from histologically benign forms to highly anaplastic and malignant tumors. Fibrillary astrocytomas are the most common type and may be classified in order of increasing malignancy (grades I through IV). In the first two decades of life, astrocytomas tend to originate in the cerebellar hemispheres; in adults, they most frequently arise in the cerebrum and frequently undergo malignant transformation. (From Devita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2013-7; Holland et al., Cancer Medicine, 3d ed, p1082)

Tumors or cancer of the LUNG.

Slender, cylindrical filaments found in the cytoskeleton of plant and animal cells. They are composed of the protein TUBULIN and are influenced by TUBULIN MODULATORS.

A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)

A microtubule subunit protein found in large quantities in mammalian brain. It has also been isolated from SPERM FLAGELLUM; CILIA; and other sources. Structurally, the protein is a dimer with a molecular weight of approximately 120,000 and a sedimentation coefficient of 5.8S. It binds to COLCHICINE; VINCRISTINE; and VINBLASTINE.

The conjugation product of LEUKOTRIENE A4 and glutathione. It is the major arachidonic acid metabolite in macrophages and human mast cells as well as in antigen-sensitized lung tissue. It stimulates mucus secretion in the lung, and produces contractions of nonvascular and some VASCULAR SMOOTH MUSCLE. (From Dictionary of Prostaglandins and Related Compounds, 1990)

Alkylating antineoplastic toxic to bone marrow; used in breast cancer, also in combination with other drugs.

Primary or metastatic neoplasms of the CEREBELLUM. Tumors in this location frequently present with ATAXIA or signs of INTRACRANIAL HYPERTENSION due to obstruction of the fourth ventricle. Common primary cerebellar tumors include fibrillary ASTROCYTOMA and cerebellar HEMANGIOBLASTOMA. The cerebellum is a relatively common site for tumor metastases from the lung, breast, and other distant organs. (From Okazaki & Scheithauer, Atlas of Neuropathology, 1988, p86 and p141)

Leukemia induced experimentally in animals by exposure to leukemogenic agents, such as VIRUSES; RADIATION; or by TRANSPLANTATION of leukemic tissues.

Forms to which substances are incorporated to improve the delivery and the effectiveness of drugs. Drug carriers are used in drug-delivery systems such as the controlled-release technology to prolong in vivo drug actions, decrease drug metabolism, and reduce drug toxicity. Carriers are also used in designs to increase the effectiveness of drug delivery to the target sites of pharmacological actions. Liposomes, albumin microspheres, soluble synthetic polymers, DNA complexes, protein-drug conjugates, and carrier erythrocytes among others have been employed as biodegradable drug carriers.

An antineoplastic agent used to treat ovarian cancer. It works by inhibiting DNA TOPOISOMERASES, TYPE I.

A mixture of six synthetic oligopeptides, each containing MELPHALAN. It is used as a broad-spectrum antineoplastic due to its alkylating and antimetabolic actions but, is toxic to bone marrow, gastrointestinal system and vasculature.

Benign and malignant neoplastic processes that arise from or secondarily involve the brain, spinal cord, or meninges.

Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.

The local recurrence of a neoplasm following treatment. It arises from microscopic cells of the original neoplasm that have escaped therapeutic intervention and later become clinically visible at the original site.

An organoplatinum compound that possesses antineoplastic activity.

The return of a sign, symptom, or disease after a remission.

The application of probability and statistical methods to calculate the risk of occurrence of any event, such as onset of illness, recurrent disease, hospitalization, disability, or death. It may include calculation of the anticipated money costs of such events and of the premiums necessary to provide for payment of such costs.

Primary and metastatic (secondary) tumors of the brain located above the tentorium cerebelli, a fold of dura mater separating the CEREBELLUM and BRAIN STEM from the cerebral hemispheres and DIENCEPHALON (i.e., THALAMUS and HYPOTHALAMUS and related structures). In adults, primary neoplasms tend to arise in the supratentorial compartment, whereas in children they occur more frequently in the infratentorial space. Clinical manifestations vary with the location of the lesion, but SEIZURES; APHASIA; HEMIANOPSIA; hemiparesis; and sensory deficits are relatively common features. Metastatic supratentorial neoplasms are frequently multiple at the time of presentation.

Disorders of the blood and blood forming tissues.

A plant genus of the family ONAGRACEAE. Members contain oenotheins.

A neoplasm of prolymphocytes affecting the blood, bone marrow, and spleen. It is characterized by prolymphocytes exceeding 55% of the lymphoid cells in the blood and profound splenomegaly.

A subnormal level of BLOOD PLATELETS.

Transplantation of an individual's own tissue from one site to another site.

A class of drugs that differs from other alkylating agents used clinically in that they are monofunctional and thus unable to cross-link cellular macromolecules. Among their common properties are a requirement for metabolic activation to intermediates with antitumor efficacy and the presence in their chemical structures of N-methyl groups, that after metabolism, can covalently modify cellular DNA. The precise mechanisms by which each of these drugs acts to kill tumor cells are not completely understood. (From AMA, Drug Evaluations Annual, 1994, p2026)

Works about pre-planned studies of the safety, efficacy, or optimum dosage schedule (if appropriate) of one or more diagnostic, therapeutic, or prophylactic drugs, devices, or techniques selected according to predetermined criteria of eligibility and observed for predefined evidence of favorable and unfavorable effects. This concept includes clinical trials conducted both in the U.S. and in other countries.

A form of undifferentiated malignant LYMPHOMA usually found in central Africa, but also reported in other parts of the world. It is commonly manifested as a large osteolytic lesion in the jaw or as an abdominal mass. B-cell antigens are expressed on the immature cells that make up the tumor in virtually all cases of Burkitt lymphoma. The Epstein-Barr virus (HERPESVIRUS 4, HUMAN) has been isolated from Burkitt lymphoma cases in Africa and it is implicated as the causative agent in these cases; however, most non-African cases are EBV-negative.

An anthracycline which is the 4'-epi-isomer of doxorubicin. The compound exerts its antitumor effects by interference with the synthesis and function of DNA.

The exposure of the head to roentgen rays or other forms of radioactivity for therapeutic or preventive purposes.

A glycoprotein of MW 25 kDa containing internal disulfide bonds. It induces the survival, proliferation, and differentiation of neutrophilic granulocyte precursor cells and functionally activates mature blood neutrophils. Among the family of colony-stimulating factors, G-CSF is the most potent inducer of terminal differentiation to granulocytes and macrophages of leukemic myeloid cell lines.

The long-term (minutes to hours) administration of a fluid into the vein through venipuncture, either by letting the fluid flow by gravity or by pumping it.

A cell line derived from cultured tumor cells.

Antibodies produced by a single clone of cells.

A decrease in the number of NEUTROPHILS found in the blood.

FEVER accompanied by a significant reduction in NEUTROPHIL count associated with CHEMOTHERAPY.

Neurologic disorders caused by exposure to toxic substances through ingestion, injection, cutaneous application, or other method. This includes conditions caused by biologic, chemical, and pharmaceutical agents.

A therapeutic approach, involving chemotherapy, radiation therapy, or surgery, after initial regimens have failed to lead to improvement in a patient's condition. Salvage therapy is most often used for neoplastic diseases.

A form of non-Hodgkin lymphoma having a usually diffuse pattern with both small and medium lymphocytes and small cleaved cells. It accounts for about 5% of adult non-Hodgkin lymphomas in the United States and Europe. The majority of mantle-cell lymphomas are associated with a t(11;14) translocation resulting in overexpression of the CYCLIN D1 gene (GENES, BCL-1).

Genes for MEMBRANE TRANSPORT PROTEINS that confer resistance to toxic compounds. Several superfamilies of these multidrug export proteins are known and found in both prokaryotes and eukaryotes.

Tumors or cancer of the RETINA.

A group of closely related cyclic undecapeptides from the fungi Trichoderma polysporum and Cylindocarpon lucidum. They have some antineoplastic and antifungal action and significant immunosuppressive effects. Cyclosporins have been proposed as adjuvants in tissue and organ transplantation to suppress graft rejection.

Organic nitrogenous bases. Many alkaloids of medical importance occur in the animal and vegetable kingdoms, and some have been synthesized. (Grant & Hackh's Chemical Dictionary, 5th ed)

An anabolic steroid that has been used in the treatment of male HYPOGONADISM, delayed puberty in males, and in the treatment of breast neoplasms in women.

A process involving chance used in therapeutic trials or other research endeavor for allocating experimental subjects, human or animal, between treatment and control groups, or among treatment groups. It may also apply to experiments on inanimate objects.

Agents which affect CELL DIVISION and the MITOTIC SPINDLE APPARATUS resulting in the loss or gain of whole CHROMOSOMES, thereby inducing an ANEUPLOIDY.

Drug therapy given to augment or stimulate some other form of treatment such as surgery or radiation therapy. Adjuvant chemotherapy is commonly used in the therapy of cancer and can be administered before or after the primary treatment.

A group of malignant tumors of the nervous system that feature primitive cells with elements of neuronal and/or glial differentiation. Use of this term is limited by some authors to central nervous system tumors and others include neoplasms of similar origin which arise extracranially (i.e., NEUROECTODERMAL TUMORS, PRIMITIVE, PERIPHERAL). This term is also occasionally used as a synonym for MEDULLOBLASTOMA. In general, these tumors arise in the first decade of life and tend to be highly malignant. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, p2059)

Agents that interact with TUBULIN to inhibit or promote polymerization of MICROTUBULES.

Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.

A group of diseases arising from pregnancy that are commonly associated with hyperplasia of trophoblasts (TROPHOBLAST) and markedly elevated human CHORIONIC GONADOTROPIN. They include HYDATIDIFORM MOLE, invasive mole (HYDATIDIFORM MOLE, INVASIVE), placental-site trophoblastic tumor (TROPHOBLASTIC TUMOR, PLACENTAL SITE), and CHORIOCARCINOMA. These neoplasms have varying propensities for invasion and spread.

Injections made into a vein for therapeutic or experimental purposes.

B-cell lymphoid tumors that occur in association with AIDS. Patients often present with an advanced stage of disease and highly malignant subtypes including BURKITT LYMPHOMA; IMMUNOBLASTIC LARGE-CELL LYMPHOMA; PRIMARY EFFUSION LYMPHOMA; and DIFFUSE, LARGE B-CELL, LYMPHOMA. The tumors are often disseminated in unusual extranodal sites and chromosomal abnormalities are frequently present. It is likely that polyclonal B-cell lymphoproliferation in AIDS is a complex result of EBV infection, HIV antigenic stimulation, and T-cell-dependent HIV activation.

Any process by which toxicity, metabolism, absorption, elimination, preferred route of administration, safe dosage range, etc., for a drug or group of drugs is determined through clinical assessment in humans or veterinary animals.

A transplantable, poorly differentiated malignant tumor which appeared originally as a spontaneous breast carcinoma in a mouse. It grows in both solid and ascitic forms.

Radiotherapy using high-energy (megavolt or higher) ionizing radiation. Types of radiation include gamma rays, produced by a radioisotope within a teletherapy unit; x-rays, electrons, protons, alpha particles (helium ions) and heavy charged ions, produced by particle acceleration; and neutrons and pi-mesons (pions), produced as secondary particles following bombardment of a target with a primary particle.

A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)

Radiotherapy given to augment some other form of treatment such as surgery or chemotherapy. Adjuvant radiotherapy is commonly used in the therapy of cancer and can be administered before or after the primary treatment.

A drug formerly used in the treatment of angina pectoris but superseded by less hazardous drugs. Prenylamine depletes myocardial catecholamine stores and has some calcium channel blocking activity. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1406)

The fission of a CELL. It includes CYTOKINESIS, when the CYTOPLASM of a cell is divided, and CELL NUCLEUS DIVISION.

Experimental transplantation of neoplasms in laboratory animals for research purposes.

A group of 20-member macrolactones in which there are three remotely substituted pyran rings that are linked by a methylene bridge and an E-disubstituted alkene, and have geminal dimethyls at C8 and C18 carbons. Some interact with PROTEIN KINASE C.

The total amount of radiation absorbed by tissues as a result of radiotherapy.

A plant species of the family VISCACEAE, order Santalales, subclass Rosidae. This is the traditional mistletoe of literature and Christmas. Members contain viscotoxin (5 kDa basic polypeptides related to thionins), beta-galactoside- and N-acetyl-D-galactosamine-specific lectin II (60 kDa), and polysaccharides. Mistletoe lectin I is a type 2 ribosome-inactivating protein. Commercial extracts include Plenosol, Eurixor, Helixor Isorel, Iscador, and NSC 635089 (ANTINEOPLASTIC AGENTS, PHYTOGENIC).

An ansa macrolide isolated from the MAYTENUS genus of East African shrubs.

The use of IONIZING RADIATION to treat malignant NEOPLASMS and some benign conditions.

Inorganic or organic compounds that contain the basic structure RB(OH)2.

Tumors or cancer located in bone tissue or specific BONES.

A malignant tumor arising from the nuclear layer of the retina that is the most common primary tumor of the eye in children. The tumor tends to occur in early childhood or infancy and may be present at birth. The majority are sporadic, but the condition may be transmitted as an autosomal dominant trait. Histologic features include dense cellularity, small round polygonal cells, and areas of calcification and necrosis. An abnormal pupil reflex (leukokoria); NYSTAGMUS, PATHOLOGIC; STRABISMUS; and visual loss represent common clinical characteristics of this condition. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, p2104)

A type of CELL NUCLEUS division by means of which the two daughter nuclei normally receive identical complements of the number of CHROMOSOMES of the somatic cells of the species.

A malignant olfactory neuroblastoma arising from the olfactory epithelium of the superior nasal cavity and cribriform plate. It is uncommon (3% of nasal tumors) and rarely is associated with the production of excess hormones (e.g., SIADH, Cushing Syndrome). It has a high propensity for multiple local recurrences and bony metastases. (From Holland et al., Cancer Medicine, 3rd ed, p1245; J Laryngol Otol 1998 Jul;112(7):628-33)

One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.

An antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia.

A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.

In vivo method of screening investigative anticancer drugs and biologic response modifiers for individual cancer patients. Fresh tumor tissue is implanted under the kidney capsule of immunocompetent mice or rats; gross and histological assessments follow several days after tumor treatment in situ.

The reaction of two molecular entities via oxidation usually catalyzed by a transition metal compound and involving dioxygen as the oxidant.

The soft tissue filling the cavities of bones. Bone marrow exists in two types, yellow and red. Yellow marrow is found in the large cavities of large bones and consists mostly of fat cells and a few primitive blood cells. Red marrow is a hematopoietic tissue and is the site of production of erythrocytes and granular leukocytes. Bone marrow is made up of a framework of connective tissue containing branching fibers with the frame being filled with marrow cells.

A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.

A group of highly cellular primitive round cell neoplasms which occur extracranially in soft tissue and bone and are derived from embryonal neural crest cells. These tumors occur primarily in children and adolescents and share a number of characteristics with EWING SARCOMA.

ISOQUINOLINES with a benzyl substituent.

Mice homozygous for the mutant autosomal recessive gene "scid" which is located on the centromeric end of chromosome 16. These mice lack mature, functional lymphocytes and are thus highly susceptible to lethal opportunistic infections if not chronically treated with antibiotics. The lack of B- and T-cell immunity resembles severe combined immunodeficiency (SCID) syndrome in human infants. SCID mice are useful as animal models since they are receptive to implantation of a human immune system producing SCID-human (SCID-hu) hematochimeric mice.

Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)

A nonparametric method of compiling LIFE TABLES or survival tables. It combines calculated probabilities of survival and estimates to allow for observations occurring beyond a measurement threshold, which are assumed to occur randomly. Time intervals are defined as ending each time an event occurs and are therefore unequal. (From Last, A Dictionary of Epidemiology, 1995)

A leukemia/lymphoma found predominately in children and adolescents and characterized by a high number of lymphoblasts and solid tumor lesions. Frequent sites involve LYMPH NODES, skin, and bones. It most commonly presents as leukemia.

A family of MEMBRANE TRANSPORT PROTEINS that require ATP hydrolysis for the transport of substrates across membranes. The protein family derives its name from the ATP-binding domain found on the protein.

A connective tissue disorder characterized by widespread thickening of SKIN with a cobblestone-like appearance. It is caused by proliferation of FIBROBLASTS and deposition of MUCIN in the DERMIS in the absence of thyroid disease. Most scleromyxedema cases are associated with a MONOCLONAL GAMMOPATHY, immunoglobulin IgG-lambda.

Introduction of therapeutic agents into the spinal region using a needle and syringe.

The movement of materials (including biochemical substances and drugs) through a biological system at the cellular level. The transport can be across cell membranes and epithelial layers. It also can occur within intracellular compartments and extracellular compartments.

The concentration of a compound needed to reduce population growth of organisms, including eukaryotic cells, by 50% in vitro. Though often expressed to denote in vitro antibacterial activity, it is also used as a benchmark for cytotoxicity to eukaryotic cells in culture.

A phenolphthalein that is used as a diagnostic aid in hepatic function determination.

A connective tissue neoplasm formed by proliferation of mesodermal cells; it is usually highly malignant.

A specific pair of GROUP F CHROMOSOMES of the human chromosome classification.

Diseases of any component of the brain (including the cerebral hemispheres, diencephalon, brain stem, and cerebellum) or the spinal cord.

In vivo methods of screening investigative anticancer drugs, biologic response modifiers or radiotherapies. Human tumor tissue or cells are transplanted into mice or rats followed by tumor treatment regimens. A variety of outcomes are monitored to assess antitumor effectiveness.

The complex series of phenomena, occurring between the end of one CELL DIVISION and the end of the next, by which cellular material is duplicated and then divided between two daughter cells. The cell cycle includes INTERPHASE, which includes G0 PHASE; G1 PHASE; S PHASE; and G2 PHASE, and CELL DIVISION PHASE.

The rate dynamics in chemical or physical systems.

Phenomena and pharmaceutics of compounds that inhibit the function of agonists (DRUG AGONISM) and inverse agonists (DRUG INVERSE AGONISM) for a specific receptor. On their own, antagonists produce no effect by themselves to a receptor, and are said to have neither intrinsic activity nor efficacy.

The action of a drug that may affect the activity, metabolism, or toxicity of another drug.

Established cell cultures that have the potential to propagate indefinitely.

Quaternary salts derived from tetrazoles. They are used in tests to distinguish between reducing sugars and simple aldehydes, for detection of dehydrogenase in tissues, cells, and bacteria, for determination of corticosteroids, and in color photography. (From Mall's Dictionary of Chemistry, 5th ed, p455)

The active metabolite of FOLIC ACID. Leucovorin is used principally as an antidote to FOLIC ACID ANTAGONISTS.

A fluorescent probe with low toxicity which is a potent substrate for P-glycoprotein and the bacterial multidrug efflux transporter. It is used to assess mitochondrial bioenergetics in living cells and to measure the efflux activity of P-glycoprotein in both normal and malignant cells. (Leukemia 1997;11(7):1124-30)

Malignant neoplasms composed of MACROPHAGES or DENDRITIC CELLS. Most histiocytic sarcomas present as localized tumor masses without a leukemic phase. Though the biological behavior of these neoplasms resemble lymphomas, their cell lineage is histiocytic not lymphoid.

Form of leukemia characterized by an uncontrolled proliferation of the myeloid lineage and their precursors (MYELOID PROGENITOR CELLS) in the bone marrow and other sites.

A measure of the quality of health care by assessment of unsuccessful results of management and procedures used in combating disease, in individual cases or series.

Absence of hair from areas where it is normally present.

Glycoproteins found on the membrane or surface of cells.

The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.

Tumors or cancer of the MEDIASTINUM.

An orally administered anthracycline antineoplastic. The compound has shown activity against BREAST NEOPLASMS; LYMPHOMA; and LEUKEMIA.

A malignant neoplasm occurring in young children, primarily in the liver, composed of tissue resembling embryonal or fetal hepatic epithelium, or mixed epithelial and mesenchymal tissues. (Stedman, 25th ed)

Diseases of the central and peripheral nervous system. This includes disorders of the brain, spinal cord, cranial nerves, peripheral nerves, nerve roots, autonomic nervous system, neuromuscular junction, and muscle.

Tumors or cancers of the KIDNEY.

An alkaloid isolated from the stem wood of the Chinese tree, Camptotheca acuminata. This compound selectively inhibits the nuclear enzyme DNA TOPOISOMERASES, TYPE I. Several semisynthetic analogs of camptothecin have demonstrated antitumor activity.

Tumors or cancer of the INTESTINES.

Malignant neoplasms arising in the neuroectoderm, the portion of the ectoderm of the early embryo that gives rise to the central and peripheral nervous systems, including some glial cells.

Trophoblastic growth, which may be gestational or nongestational in origin. Trophoblastic neoplasia resulting from pregnancy is often described as gestational trophoblastic disease to distinguish it from germ cell tumors which frequently show trophoblastic elements, and from the trophoblastic differentiation which sometimes occurs in a wide variety of epithelial cancers. Gestational trophoblastic growth has several forms, including HYDATIDIFORM MOLE and CHORIOCARCINOMA. (From Holland et al., Cancer Medicine, 3d ed, p1691)

Mild to moderate loss of bilateral lower extremity motor function, which may be a manifestation of SPINAL CORD DISEASES; PERIPHERAL NERVOUS SYSTEM DISEASES; MUSCULAR DISEASES; INTRACRANIAL HYPERTENSION; parasagittal brain lesions; and other conditions.

Prednisone in MOPP chemotherapy for Hodgkin's disease. (1/3052)

High remission rates have been produced by MOPP (mustine, vincristine, procarbazine, and prednisone) chemotherapy in patients with advanced Hodgkin's disease, but the prednisone component has caused adverse effects in patients who have undergone radiotherapy. The remission rates and length of remission were reviewed in 211 patients with Hodgkin's disease who received chemotherapy either with or without prednisone. In contrast to the findings of a British study, there were no significant differences in remission rates or length of remission between patients who had received prednisone and patients who had not. There were differences between the British prospective study and this retrospective one, but it is difficult to know what accounted for the substantial differences in the findings. (+info)

Electronic volume analysis of L1210 chemotherapy. (2/3052)

The rapid analysis of in vivo chemotherapy on the L1210 ascites tumor grown in C57BL/6 X DBA/2F1 mice has been shown by means of an electronic volume analysis. The drugs were injected on the 4th day of tumor growth, and the cells in the peritoneal cavity were studied at 24-hr intervals on the 5th through 7th day. Using the electronic cell volume distributions, combined with labeling indices, cell morphology, and cell counts, it was found that the alkylating agents. 1,3-bis(2-chloroethyl)-1-nitrosourea and cyclophosphamide, at the dosages used, were more effective than the S-phase-specific drugs, palmitoyl ester of 1-beta-D-arabinofuranosylcytosine, vincristine, and methotrexate. (+info)

Analysis of the effects of food and of digestive secretions on the small intestine of the rat. 1. Mucosal morphology and epithelial replacement. (3/3052)

A modified Roux-en-Y repositioning of rat small intestine was performed so that the proximal segment of bowel (A) received only bile and pancreastic secretions, the second (B) received food direct from the stomach, and these two segments drained into a third (C). Four to five weeks after operation, cell production was assessed by injection of vincristine into operated, sham-operated and unoperated rats, and counts of blocked metaphases were made on isolated microdissected crypts. Villus height, crypt depth, and the number of crypts per villus (crypt/villus ratio) were also measured. Most of segment A showed no significant differences from sham-operated intestine, although the normal proximo-distal gradient of villus height was abolished. At the distal end (near the anastomosis with segments B and C), crypt depth and cell production were increased. The villus height gradient in segment B was also abolished, although crypt depth and cell production were significantly increased, especially at the proximal end. Crypt/villus ratio was also increased. Segment C showed all the characteristics of small bowel promoted to a more proximal position: increased villus height, crypt depth and cell production. Increased crypt/villus ratio was also observed. These results are discussed in terms of the role of food and of digestive secretions in the control of mucosal morphology and epithelial replacement. (+info)

Can we cure indolent lymphomas? (4/3052)

The current consensus is that indolent lymphomas are incurable disorders. There are some indications that these malignancies are potentially curable. Indeed, not all indolent lymphomas are currently incurable. For example, patients with Ann Arbor stage I-II indolent lymphomas can experience long-term disease-free survival and probable cure. Also, from the available literature data, it seems that the achievement of a molecular complete remission is a desirable objective. Patients who achieve a persistently negative PCR state seldom relapse, whereas the opposite is true for persistently positive cases. In view of its excellent correlation with disease-free survival when examined serially in multiple blood or marrow samples, the PCR technique has the potential of providing a tumor marker that can be used as an early end point for clinical trials. By serving as an early surrogate end point, PCR could play an important role in expediting the development of new treatment strategies. Whether IFN is capable of increasing the molecular complete remission rate as measured by PCR is not known. However, it is clear that from the clinical standpoint, IFN has been able to increase 2-fold the length of remission in patients with advanced indolent lymphomas. In at least two studies, this has been associated with prolongation of survival. More intensive regimens such as alternating triple therapy, when used in combination with IFN, seem to have improved the quality of remissions as judged by the PCR assay. Finally, the site where the bcl-2 breakpoint occurs seems to have clinical significance. Those follicular lymphomas with germ-line bcl-2, in our experience, have behaved more aggressively than the others, and their failure-free survival seems different from the usual indolent lymphomas and more closely resembles the large cell lymphomas. Although the biological significance of this observation is not yet understood, this group might actually constitute a prognostically different subset with a more aggressive and perhaps more curable lymphoma. Whether the plateau observed in their failure-free survival curve will be maintained with more follow-up and whether they might be a curable subset remain to be determined. (+info)

Topotecan versus cyclophosphamide, doxorubicin, and vincristine for the treatment of recurrent small-cell lung cancer. (5/3052)

PURPOSE: Topotecan and cyclophosphamide, doxorubicin, and vincristine (CAV) were evaluated in a randomized, multicenter study of patients with small-cell lung cancer (SCLC) who had relapsed at least 60 days after completion of first-line therapy. PATIENTS AND METHODS: Patients received either topotecan (1.5 mg/m2) as a 30-minute infusion daily for 5 days every 21 days (n = 107) or CAV (cyclophosphamide 1,000 mg/m2, doxorubicin 45 mg/m2, and vincristine 2 mg) infused on day 1 every 21 days (n = 104). Eligibility included the following: bidimensionally measurable disease, Eastern Cooperative Oncology Group performance status of less than or equal to 2, and adequate marrow, liver, and renal function. Response was confirmed by blinded independent radiologic review. RESULTS: Response rate was 26 of 107 patients (24.3%) treated with topotecan and 19 of 104 patients (18.3%) treated with CAV (P = .285). Median times to progression were 13.3 weeks (topotecan) and 12.3 weeks (CAV) (P = .552). Median survival was 25.0 weeks for topotecan and 24.7 weeks for CAV (P = .795). The proportion of patients who experienced symptom improvement was greater in the topotecan group than in the CAV group for four of eight symptoms evaluated, including dyspnea, anorexia, hoarseness, and fatigue, as well as interference with daily activity (P< or =.043). Grade 4 neutropenia occurred in 37.8% of topotecan courses versus 51.4% of CAV courses (P<.001). Grade 4 thrombocytopenia and grade 3/4 anemia occurred more frequently with topotecan, occurring in 9.8% and 17.7% of topotecan courses versus 1.4% and 7.2% of CAV courses, respectively (P<.001 for both). Nonhematologic toxicities were generally grade 1 to 2 for both regimens. CONCLUSION: Topotecan was at least as effective as CAV in the treatment of patients with recurrent SCLC and resulted in improved control of several symptoms. (+info)

Phase I study of liposomal vincristine. (6/3052)

PURPOSE: A phase I study of vincristine encapsulated inside 120-nm-diameter distearoylphosphatidylcholine-cholesterol liposomes was performed. The primary objectives were to determine the maximum-tolerated dose (MTD), recommended phase II dose, toxicity, and pharmacokinetics of liposomal vincristine (ONCO-TCS). PATIENTS AND METHODS: Twenty-five patients with histologically confirmed malignancies were enrolled and assessable. Vincristine doses were increased from 0.5 mg/m2 to 1.0, 1.5, 2.0, 2.4, and 2.8 mg/m2 with cohorts of three or more patients per dose level. A total of 64 courses of ONCO-TCS were administered intravenously once every 3 weeks. The pharmacokinetics of total vincristine content in plasma were determined using a high-performance liquid chromatography method. RESULTS: Patients were treated with vincristine doses up to 2.8 mg/m2; however, 2.4 mg/m2 was defined as the MTD and 2.0 mg/m2 as the phase II recommended dose. Pain and obstipation were the dose-limiting toxicites. Other toxicities were fever, rigors, fatigue, myalgias, and peripheral neuropathy. Hematologic toxicity was mild. All patients who were treated with doses above 1.5 mg/m2 received in excess of 2.0 mg of vincristine, with doses as high as 6.2 mg. One partial response was seen in a patient with pancreatic cancer. Tumor response not meeting partial response criteria was seen in two other patients. Pharmacokinetic studies revealed significantly elevated concentrations of total vincristine, but parameters varied and were not directly correlated with toxicity or response. CONCLUSION: The ability to administer elevated doses of vincristine, as well as indications of efficacy, suggests that ONCO-TCS warrants further clinical investigation in a phase II setting. (+info)

Early harvest and late transplantation as an effective therapeutic strategy in multiple myeloma. (7/3052)

Transplantation after high-dose chemotherapy prolongs survival in patients with multiple myeloma compared with standard therapy. It is unclear whether the optimal timing of transplantation is immediately after induction chemotherapy or whether stem cells may be cryopreserved for transplantation at subsequent progression or relapse. In this study, stem cells were collected within 6 months of diagnosis, followed by transplantation only at progression of myeloma. One hundred and eighteen patients with multiple myeloma had stem cells collected and cryopreserved. Eleven had transplants early in the disease after they demonstrated failure to respond to primary therapy. The remaining 107 were eligible for transplants when there was evidence of progressive disease. Of the 118 patients, 67 had transplants, nine died of progressive disease before transplantation, and 42 remain alive in plateau phase. The median survival of the group is 58.5 months; 67 are alive. Serum beta2-microglobulin, bone marrow labeling index (S phase), and hemoglobin level predicted overall survival (P < 0.006, P < 0.001, and P < 0.01, respectively). We conclude that early cryopreservation of blood stem cells followed by transplantation at progression is a feasible approach to therapy in patients with myeloma. The underlying biology of the disease has a greater impact on survival than the timing of transplantation. A prospective randomized trial is required to answer definitively the question of the optimal timing of blood cell transplantation. (+info)

Progressive multifocal leukoencephalopathy after autologous bone marrow transplantation and alpha-interferon immunotherapy. (8/3052)

A patient with a stage IV mantle cell lymphoma (according to the REAL classification) was treated with high-dose chemotherapy and autologous bone marrow transplantation. One year later while on alpha-interferon immunotherapy she suffered from progressive loss of short-term memory and reported difficulties in recognizing objects. Magnetic resonance imaging (MRI) showed a vast ring-enhancing lesion of the left postcentral parietal area. Serial stereotactic biopsies disclosed progressive multifocal leukoencephalopathy without JC-virus in the cerebrospinal fluid. Therapy with subcutaneous interleukin-2 (IL-2) every other day and intrathecal cytarabine once a week was started. After 4 weeks the patient refused further treatment. Nevertheless her condition improved over the next 8 months and MRI scans showed a marked improvement in the lesions. (+info)

"Vincristine (Oncovin)". Archived from the original on 2007-06-29. Retrieved 2007-08-05. Fighting Cancer with a Pinch of Parsley ... Vincristine-used to treat lymphoma, breast cancer, lung cancer, and acute lymphoblastic leukemia. Vindesine-used to treat ... vincristine, and vinorelbine.Colchicine and griseofulvin are mitotic inhibitors used in the treatment of gout and toenail ...

https://en.wikipedia.org/wiki/Mitotic_inhibitor

"Vincristine - FDA prescribing information, side effects and uses". Drugs.com. Retrieved 2018-03-10. "Vincristine: Mechanism of ... Vincristine is a drug isolated from the Madagascar periwinkle, first discovered by the Eli Lilly company in 1958 in a search ... Vincristine functions by binding to and inhibiting microtubule production in the mitotic spindle necessary for the cellular ... The VAMP regimen developed by Freireich and Frei was a combination of vincristine, amethopterin, mercaptopurine, and prednisone ...

https://en.wikipedia.org/wiki/VAMP_regimen

The drugs vinblastine and vincristine are vinca alkaloids, used to treat Hodgkin lymphoma, leukemia, and other cancers, were ... vincristine". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 11966-11970. Bibcode: ... "Modifications on the basic skeletons of vinblastine and vincristine". Molecules. 17 (5): 5893-5914. doi:10.3390/ ...

https://en.wikipedia.org/wiki/Madagascar

Accidental administration of any vinca alkaloids-especially vincristine but also vinblastine, vinorelbine, or others-via the ... Schulmeister L (September 2004). "Preventing vincristine sulfate medication errors". Oncology Nursing Forum. 31 (5): E90-8. doi ... Qweider M, Gilsbach JM, Rohde V (March 2007). "Inadvertent intrathecal vincristine administration: a neurosurgical emergency. ...

https://en.wikipedia.org/wiki/Intrathecal_administration

These compounds include vinblastine, vincristine, vindesine, and vinorelbine. Additional researched vinca alkaloids include ... vincristine". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 11966-11970. Bibcode: ... leurosine and the chemotherapy agents vinblastine and vincristine, all of which can be obtained from the plant. The newer semi- ... "Modifications on the basic skeletons of vinblastine and vincristine". Molecules. 17 (5): 5893-5914. doi:10.3390/ ...

https://en.wikipedia.org/wiki/Vinca_alkaloid

Moncrief, J. W.; Lipscomb, W. N. (1965). "Structures of Leurocristine (Vincristine) and Vincaleukoblastine. X-ray Analysis of ... Vincristine), which is used in several cancer therapies. Guggenheim Fellow, 1954 Fellow of the American Academy of Arts and ...

https://en.wikipedia.org/wiki/William_Lipscomb

Methotrexate and vincristine have also been used. Other medications include cytokine targeted therapy.[citation needed] On 20 ...

https://en.wikipedia.org/wiki/Hemophagocytic_lymphohistiocytosis

... vincristine, doxorubicin, plus dacarbazine or cisplatin; cyclophosphamide, doxorubicin, plus dacarbazine; high dose ...

https://en.wikipedia.org/wiki/Undifferentiated_pleomorphic_sarcoma

Anticancer drugs such as doxorubicin and vincristine can adversely affect male fertility by damaging the DNA of proliferative ... Experimental exposure of rat undifferentiated spermatogonia to doxorubicin and vincristine indicated that these cells are able ... Beaud H, van Pelt A, Delbes G (2017). "Doxorubicin and vincristine affect undifferentiated rat spermatogonia". Reproduction. ...

https://en.wikipedia.org/wiki/Spermatogonium

Vincristine, which requires central venous access for administration, is traditionally used as a chemotherapy agent, but has ... 2004). "Vincristine treatment for function- and life-threatening infantile hemangioma". Arch Pediatr. 11 (2): 99-107. doi: ... Other systemic therapies which may be effective for IH treatment include vincristine, interferon, and other agents with ... "Treatment of life-threatening infantile hemangiomas with vincristine". N Engl J Med. 333 (1): 69. doi:10.1056/ ...

https://en.wikipedia.org/wiki/Infantile_hemangioma

Commonly used drugs include cisplatin, vincristine, and methotrexate.[clarification needed] Side effects include anemia ( ...

https://en.wikipedia.org/wiki/Urethral_cancer

"Selective metabolism of vincristine in vitro by CYP3A5". Drug Metabolism and Disposition. 34 (8): 1317-1327. doi:10.1124/dmd. ...

https://en.wikipedia.org/wiki/CYP3A5

... leurosine and the chemotherapy agents vinblastine and vincristine, all of which can be obtained from the plant. The newer semi- ... "Modifications on the basic skeletons of vinblastine and vincristine". Molecules. 17 (5): 5893-5914. doi:10.3390/ ...

https://en.wikipedia.org/wiki/Vinorelbine

Keglevich P, Hazai L, Kalaus G, Szántay C (May 2012). "Modifications on the basic skeletons of vinblastine and vincristine". ... On the other hand, therapies with low risk of gonadotoxicity include plant derivatives such as vincristine and vinblastine, ... The original vinca alkaloids are natural products that include vincristine and vinblastine. Following the success of these ...

https://en.wikipedia.org/wiki/Chemotherapy

Bisindole alkaloids vinblastine and vincristine are produced in the reaction involving catharanthine (alkaloid of type Iboga) ... Besides, bisindole alkaloids vinblastine and vincristine show antineoplastic effect. Because of structural similarities with ... vincristine). Apart from bisindole alkaloids, dimeric alkaloids exist which are formed via dimerization of the indole monomer ... and bisindole alkaloids vinblastine and vincristine are antitumor agents. Animal studies have shown that ibogaine has a ...

https://en.wikipedia.org/wiki/Indole_alkaloid

The chemotherapy agent vincristine is extracted from a closely related species, Catharanthus roseus, and is used to treat some ... Vinblastine is a chemical analogue of vincristine and is also used to treat various forms of cancer. Dimeric alkaloids such as ... "Modifications on the basic skeletons of vinblastine and vincristine". Molecules. 17 (5): 5893-5914. doi:10.3390/ ... vincristine and vinblastine are produced by the coupling the smaller indole alkaloids vindoline and catharanthine. In addition ...

https://en.wikipedia.org/wiki/Vinca

Parasramka S, Talari G, Rosenfeld M, Guo J, Villano JL (July 2017). "Procarbazine, lomustine and vincristine for recurrent high ... lomustine and vincristine). A mutational analysis of 23 initial low-grade gliomas and recurrent tumors from the same patients ...

https://en.wikipedia.org/wiki/Glioma

... such as the vinca alkaloids vinblastine and vincristine, which are formed from the coupling of catharanthine and vindoline. The ... "Modifications on the basic skeletons of vinblastine and vincristine". Molecules. 17 (5): 5893-5914. doi:10.3390/ ...

https://en.wikipedia.org/wiki/Alkaloid

Keglevich P, Hazai L, Kalaus G, Szántay C (May 2012). "Modifications on the basic skeletons of vinblastine and vincristine". ... the vinca alkaloids vincristine and vinblastine, the taxanes paclitaxel and docetaxel, the proteasome inhibitors such as ...

https://en.wikipedia.org/wiki/Linezolid

https://en.wikipedia.org/wiki/Bis(cyclopentadienyl)titanium(III)_chloride

"Modifications on the basic skeletons of vinblastine and vincristine". Molecules. 17 (5): 5893-5914. doi:10.3390/ ...

https://en.wikipedia.org/wiki/Laboratoires_Pierre_Fabre

... is a vinca alkaloid and a chemical analogue of vincristine. It binds tubulin, thereby inhibiting the assembly of ... Keglevich P, Hazai L, Kalaus G, Szántay C (May 2012). "Modifications on the basic skeletons of vinblastine and vincristine". ...

https://en.wikipedia.org/wiki/Vinblastine

Most of the drugs used in dogs are used in cats, but the most common protocol uses cyclophosphamide, vincristine, and ... The most common protocol uses prednisone, vincristine, and cyclophosphamide. Doxorubicin is used in some cases. Chemotherapy in ... The most common treatment is a combination of cyclophosphamide, vincristine, prednisone, L-asparaginase, and doxorubicin. Other ...

https://en.wikipedia.org/wiki/Lymphoma_in_animals

The vinca alkaloids, including vincristine, are also associated with reversible ototoxicity. Topical skin preparations such as ... "Modifications on the basic skeletons of vinblastine and vincristine". Molecules. 17 (5): 5893-914. doi:10.3390/ ...

https://en.wikipedia.org/wiki/Ototoxicity

February 2004). "[Vincristine treatment for function- and life-threatening infantile hemangioma]". Archives de Pédiatrie. 11 (2 ...

https://en.wikipedia.org/wiki/Diffuse_neonatal_hemangiomatosis

The plant produces about 130 of these compounds, including vinblastine and vincristine, two drugs used to treat cancer. ... "Modifications on the basic skeletons of vinblastine and vincristine". Molecules. 17 (5): 5893-5914. doi:10.3390/ ...

https://en.wikipedia.org/wiki/Catharanthus

Vinblastine and vincristine, chemotherapy medications used to treat several types of cancers, are found in the plant and are ... It is a source of the drugs vincristine and vinblastine, used to treat cancer. It was formerly included in the genus Vinca as ... Despite the medical importance and wide use, the desired alkaloids (vinblastine and vincristine) are naturally produced at very ... In the 1950s, vinca alkaloids, including vinblastine and vincristine, were isolated from Catharanthus roseus while screening ...

https://en.wikipedia.org/wiki/Catharanthus_roseus

Keglevich P, Hazai L, Kalaus G, Szántay C (May 2012). "Modifications on the basic skeletons of vinblastine and vincristine". ... Tubulins are targets for anticancer drugs such as vinblastine and vincristine, and paclitaxel. The anti-worm drugs mebendazole ...

https://en.wikipedia.org/wiki/Tubulin

Etoposide, vincristine, dactinomycin, and cyclophosphamide have also traditionally been given. Newer chemotherapies, such as ...

https://en.wikipedia.org/wiki/Epithelioid_sarcoma

5-Year relative survival rate: Age 20-44, 76%. Age 45-54, 67%. Age 55-64, 45%. Procarbazine, lomustine and vincristine have ... For further treatment, radiation or chemotherapy with temozolomide or a chemotherapy with Procarbazine, CCNU and Vincristine ( ... and vincristine combination chemotherapy in the treatment of malignant brain tumors". Cancer. 35 (5): 1398-404. doi:10.1002/ ...

https://en.wikipedia.org/wiki/Anaplastic_oligodendroglioma

Vincristine Injection: learn about side effects, dosage, special precautions, and more on MedlinePlus ... Before receiving vincristine,. *tell your doctor and pharmacist if you are allergic to vincristine, any other medications, or ... Talk to your doctor about the risks of receiving vincristine injection.. Vincristine may cause other side effects. Call your ... If you become pregnant while receiving vincristine injection, call your doctor. Vincristine may harm the fetus. ...

https://medlineplus.gov/druginfo/meds/a682822.html

Testing Status of Vincristine C04864. CASRN: 57-22-7. Formula: C46-H56-N4-O10. Synonyms/Common Names. *22-Oxovincaleukoblastine ...

https://ntp.niehs.nih.gov/whatwestudy/testpgm/status/ts-c04864.html

https://scienceline.org/tag/vincristine/

Vincristine is often given as part of multidrug regimens, which may include agents delivered intrathecally. If vincristine is ... NCCN Launches Campaign on Vincristine Safety. - Just Bag It promotes a simple practice change that can save lives. by Eric T ... Vincristine manufacturers and pharmacists have been issuing warning labels, but when an error is made it is most likely to ... "Four of them have the opportunity to see that the vincristine is in a mini-bag. Its a simple fix and there should be few ...

https://www.medpagetoday.com/hematologyoncology/chemotherapy/61340

MarqiboWhat is the most important information I should know about vincristine liposome?You should not use this medicine if you ... How is vincristine liposome given?. Vincristine liposome is given as an infusion into a vein, usually once a week. A healthcare ... What is vincristine liposome?. Vincristine liposome is used to treat a type of blood cancer called Philadelphia chromosome ... What should I discuss with my healthcare provider before receiving vincristine liposome?. You should not use vincristine ...

https://www.uofmhealth.org/health-library/d07892a1

Vincristine belongs to the group of cancer-fighting medications known as antineoplastics. It causes the death of cancer cells ... Vincristine is injected into a vein through a specially prepared site on your skin that has been prepared for this purpose. It ... Vincristine sometimes causes mild nausea and vomiting, but it is important to keep using this medication even if you feel ill. ... Vincristine belongs to the group of cancer-fighting medications known as antineoplastics. It causes the death of cancer cells ...

https://medbroadcast.com/drug/getdrug/vincristine-by-pfizer

The other supplier of vincristine in the US, Teva Pharmaceuticals, made a ... Vincristine Shortage - Update and Action To the Childhood Cancer Community. Editors Note: We do not have anyone in our family ... Vincristine Shortage At the beginning of October, pharmacists at COG member institutions raised concerns about the ability to ... The other supplier of vincristine in the US, Teva Pharmaceuticals, made a "business decision" and stopped supplying drug to the ...

http://seniorwomen.com/news/index.php/vincristine-shortage-update-and-action-to-the-childhood-cancer-community

Bleomycin and Vincristine in the treatment of AIDS-Related KS. Int Conf AIDS. 1996 Jul 7-12;11(Program Supplement):27 (abstract ... Vincristine. Sarcoma, Kaposi. Liposomes. Doxorubicin. Drug Therapy, Combination. Acquired Immunodeficiency Syndrome. Bleomycin ... Drug: Doxorubicin hydrochloride (liposomal) Drug: Bleomycin sulfate Drug: Vincristine sulfate Phase 3 ... Vincristine. Antibiotics, Antineoplastic. Antineoplastic Agents. Topoisomerase II Inhibitors. Topoisomerase Inhibitors. Enzyme ...

https://clinicaltrials.gov/show/NCT00002105

The Effects of Viscum album (Mistletoe) QuFrF Extract and Vincristine in Human Multiple Myeloma Cell Lines - A Comparative ...

https://www.intechopen.com/chapters/32143

Efficacy of vincristine and cyclophosphamide in the therapy of recurrent medulloblastoma. ... Efficacy of vincristine and cyclophosphamide in the therapy of recurrent medulloblastoma. Journal Article (Journal Article) ... We conducted a Phase II study of combination therapy with vincristine and cyclophosphamide in the treatment of patients with ... Fourteen patients were treated with vincristine 2 mg/m2 (2.0-mg maximal dose) by intravenous bolus on Day 1 and ...

https://scholars.duke.edu/display/pub669383

Arm B: PCV alone(1) CCNU, 110 mg/m2 p.o., day 1 Procarcazine, 60 mg/m2 p.o./day, days 8-21 Vincristine, 1.4 mg/m2 i.v. (max, ... Vincristine (DFMO-PCV) Versus PCV for Glioblastoma Multiforme1 Victor A. Levin; Victor A. Levin ... Vincristine, 1.4 mg/m2 i.v. (max, 2.0 mg), day 22 and day 43 DFMO, 3.0 g/m2 p.o. every 8 h,days 29-42 The cycle was repeated at ... Vincristine (DFMO-PCV) Versus PCV for Glioblastoma Multiforme1. Clin Cancer Res 1 October 2000; 6 (10): 3878-3884. ...

https://aacrjournals.org/clincancerres/article/6/10/3878/287881/Phase-III-Randomized-Study-of-Postradiotherapy

... and vincristine (EMA-CO) chemotherapy for the treatment of high-risk gestational trophoblastic neoplasia. Methods Forty-five ... and vincristine (EMA-CO) chemotherapy for the treatment of high-risk gestational trophoblastic neoplasia. Methods Forty-five ... and vincristine (EMA-CO) chemotherapy for the treatment of high-risk gestational trophoblastic neoplasia. Methods Forty-five ... and vincristine (EMA-CO) chemotherapy for the treatment of high-risk gestational trophoblastic neoplasia. Methods Forty-five ...

https://www.scholars.northwestern.edu/en/publications/treatment-of-high-risk-gestational-trophoblastic-neoplasia-with-e

On the contrary, Oncovin is the trade name for vincristine. The distinction is important, for although vinblastine is regarded ... as more beneficial when used alone in Hodgkins disease, vincristine is regarded as the drug of choice in the MOPP regimen, ...

http://scholars.uab.edu/display/pub1189878

Find information on Vincristine (Vincasar PFS) in Daviss Drug Guide including dosage, side effects, interactions, nursing ... "VinCRIStine." Daviss Drug Guide, 18th ed., F.A. Davis Company, 2023. Daviss Drug Guide - OLD - USE 2.0, www.drugguide.com/ddo ... Davis-Drug-Guide/51789/all/vinCRIStine. Vallerand AHA, Sanoski CAC, Quiring CC. VinCRIStine. Daviss Drug Guide. F.A. Davis ... vinCRIStine is a topic covered in the Daviss Drug Guide. To view the entire topic, please log in or purchase a subscription. ...

https://www.drugguide.com/ddo/view/Davis-Drug-Guide/51789/all/vinCRIStine?q=zidovudine

WHO GMP Certified Global Pharmaceutical Company, Manufacturer, Supplier and Exporter of Cytocristin Vincristine Sulphate 1mg/ ... The concentration of Vincristine Sulphate Injection is 1 mg/mL. Do not add extra fluid to the vial prior to removal of the dose ... Vincristine sulphate is used either alone or in conjunction with other oncolytic drugs for the treatment of: ... Withdraw the solution of Vincristine Sulfate Injection, USP into an accurate dry syringe, measuring the dose carefully. ...

https://www.heethealthcare.co.in/cytocristin-vincristine-sulphate-1mg-1ml-4312698.html

Radiation plus Procarbazine, CCNU, and Vincristine in Low-Grade Glioma. N Engl J Med. 2016 Apr 7. 374 (14):1344-55. [QxMD ...

https://www.medscape.com/answers/283453-159682/which-medications-in-the-drug-class-anticonvulsants-are-used-in-the-treatment-of-astrocytoma

Vincristine is used in hematologic and nonhematologic malignancies. It is a component of CHOP and other regimens for lymphoma. ... The mechanism of action of vincristine is uncertain. It may involve a decrease in reticuloendothelial cell function or an ... Intravascular large B-cell lymphoma: Remission after rituximab-cyclophosphamide, doxorubicin, vincristine, and prednisolone ... vincristine, prednisone (CHOP) or other anthracycline-based chemotherapy regimens. ...

https://emedicine.medscape.com/article/203399-medication

We investigated the feasibility and efficacy of high-dose vincristine (4 mg/m2 over 4 d) combined with fractionated total body ... T1 - High-dose vincristine, fractionated total-body irradiation and cyclophosphamide as conditioning regimen in allogeneic and ... High-dose vincristine, fractionated total-body irradiation and cyclophosphamide as conditioning regimen in allogeneic and ... High-dose vincristine, fractionated total-body irradiation and cyclophosphamide as conditioning regimen in allogeneic and ...

https://moh-it.pure.elsevier.com/en/publications/high-dose-vincristine-fractionated-total-body-irradiation-and-cyc

vincristine-04. Published July 9, 2018. at 644 × 265 in VinCRIStine Sulfate ...

https://themedidex.com/drugs/vincristine-sulfate/vincristine-04-2/

Bilateral vocal cord paralysis following treatment with vincristine.. Authors: Naithani, Rahul. Dolai, Tuphan Kanti. Kumar, ... The neurotoxicity of the vincristine is well known, however, cranial neuropathy is not widely recognized. We describe a child ... Naithani R, Dolai TK, Kumar R. Bilateral vocal cord paralysis following treatment with vincristine. Indian Pediatrics. 2009 Jan ... Vocal cord paralysis resolved spontaneously upon withdrawal of the vincristine. Vinca-alkaloid-induced vocal cord paralysis is ...

https://imsear.searo.who.int/handle/123456789/12715

Dive into the research topics of Pilot Study of Adding Vincristine, Topotecan, and Cyclophosphamide to Interval-Compressed ... Pilot Study of Adding Vincristine, Topotecan, and Cyclophosphamide to Interval-Compressed Chemotherapy in Newly Diagnosed ...

https://einstein.pure.elsevier.com/en/publications/pilot-study-of-adding-vincristine-topotecan-and-cyclophosphamide--3/fingerprints/

Vincristine may cause hair loss, vomiting, nausea or diarrhea. Toxic effects of vincristine can affect the nervous system, ... Vincristine (Oncovin) is used to treat malignant cancers of the lymphoid and blood systems. It has also been used to treat ... Vincristine should be avoided in animals with liver disease, low white blood cell counts, active infections or disease of the ... Vincristine is chiefly used as one drug in multi-drug combination protocols against lymphoid and round cell tumors. Lymphoma, ...

https://www.californiapetpharmacy.com/vincristine-2mg2ml-injection-2ml-vial.html

We are back at our weekly vincristine dose, one this week and again next week before our next hospital admission. Unfortunately ...

http://www.projectsubmarine.net/2014/07/another-round-of-vincristine.html

VAMP vincristine, amethopterine, 6-mercaptopurine, and prednisone. VB vinblastine. VC vincristine. VD venereal disease ...

https://www.cdc.gov/nchs/nvss/manuals/2020/2a-appendix-2020.htm

The addition of cyclosporine in combination with chemotherapy regimen of carboplatin, etoposide, and vincristine reportedly ...

https://emedicine.medscape.com/article/1222849-medication

Douglians › Forums › From Zero to Hero with Nodejs › L, elderly encephalitis, hepatosplenomegaly, meters transit vincristine. ...

https://douglians.com/forums/topic/l-elderly-encephalitis-hepatosplenomegaly-meters-transit-vincristine/

In an effort to save lives related to the accidental intrathecal dosing of vincristine, the National Comprehensive Cancer ... Many agents used in combination with vincristine are delivered intrathe-cally. If vincristine is mistakenly in--jected into the ... NCCN Campaign May Prevent Fatal Medication Errors by Targeting Vincristine Preparation. TOP - February 2017, Vol 10, No 1 - ... An increasing number of hospitals have adopted a policy to always bag vincristine; however, only 50% of hospitals indicate that ...

https://www.theoncologypharmacist.com/top-issues/2017-issues/february-2017-vol-10-no-1/17014-nccn-campaign-may-prevent-fatal-medication-errors-by-targeting-vincristine-preparation-top-feb2017

... vincristine, prednisone (CMFVP) in patients with metastatic breast cancer. A southeastern cancer study group project Academic ... vincristine and prednisone (CMFVP) given intermittently 1 week out of 4. Responses (64%), median duration of response (32 weeks ...

https://scholars.uab.edu/display/pub2055495

Bleomycin, Lomustine, Cyclophosphamide, Vincristine, Procarbazine and Prednisone (BLEO-CCVPP) in Patients with Hodgkins ... Dive into the research topics of Bleomycin, Lomustine, Cyclophosphamide, Vincristine, Procarbazine and Prednisone (BLEO-CCVPP ...

https://mayoclinic.pure.elsevier.com/en/publications/bleomycin-lomustine-cyclophosphamide-vincristine-procarbazine-and/fingerprints/

Bleomycin, epidoxorubicin, cyclophosphamide, vincristine and prednisone (BACOP) in patients with follicular non-Hodgkins ... Bleomycin, epidoxorubicin, cyclophosphamide, vincristine and prednisone (BACOP) in patients with follicular non-Hodgkins ... Bleomycin, epidoxorubicin, cyclophosphamide, vincristine and prednisone (BACOP) in patients with follicular non-Hodgkins ... vincristine, bleomycin and prednisone, weekly administered every 4 weeks. After chemotherapy, involved-field radiotherapy was ...

https://iris.unimore.it/handle/11380/310892

Efficacy of vincristine and cyclophosphamide in the therapy of recurrent medulloblastoma. (duke.edu)
We conducted a Phase II study of combination therapy with vincristine and cyclophosphamide in the treatment of patients with recurrent or metastatic medulloblastoma. (duke.edu)
Fourteen patients were treated with vincristine 2 mg/m2 (2.0-mg maximal dose) by intravenous bolus on Day 1 and cyclophosphamide 1 g/m2 by intravenous infusion on Days 1 and 2, with cycles repeated every 4 weeks. (duke.edu)
These therapeutic results compare favorably with other reports of therapy for recurrent medulloblastoma and support the inclusion of vincristine and cyclophosphamide in randomized adjuvant therapy trials of patients with medulloblastoma. (duke.edu)
Objective The objective of the study was to evaluate the efficacy and toxicity of etoposide, methotrexate, actinomycin D, cyclophosphamide, and vincristine (EMA-CO) chemotherapy for the treatment of high-risk gestational trophoblastic neoplasia. (northwestern.edu)
We investigated the feasibility and efficacy of high-dose vincristine (4 mg/m 2 over 4 d) combined with fractionated total body irradiation (F-TBI) (200 cGyx2 over 3 d) and cyclophosphamide (60 mg/kg for 2 d) as a preparative regimen in allogeneic (AlloBMT) and autologous (ABMT) bone marrow transplantation for 75 consecutive children (median age at transplant 8.5 years) with acute lymphoblastic leukaemia in second complete remission (CR). (elsevier.com)
We conclude that the conditioning regimen with high-dose vincristine combined with cyclophosphamide and F-TBI is feasible and promising, although its therapeutic advantage should be tested in larger series of patients enrolled in randomized studies. (elsevier.com)
It forms an important part of multiple chemotherapeutic regimens for lymphomas, including cyclophosphamide, hydroxydaunomycin (doxorubicin), vincristine (Oncovin), and prednisone (CHOP). (medscape.com)
In an ongoing prospective randomized study, 113 evaluable patients have received either a three‐drug combination that included cyclophosphamide, Adriamycin and 5‐fluorouracil (CAF) or a five‐drug combination including cyclophosphamide, methotrexate, 5‐fluorouracil, vincristine and prednisone (CMFVP) given intermittently 1 week out of 4. (uab.edu)
Seventy-three patients with FL were registered to the study and treated with combination chemotherapy consisting of cyclophosphamide, epidoxorubicin, vincristine, bleomycin and prednisone, weekly administered every 4 weeks. (unimore.it)
A combination of intravenous cyclophosphamide and vincristine (Oncovin) and oral prednisone (COP) was given every 2 weeks to 262 patients with disseminated Hodgkin's disease, lymphosarcoma, reticulum cell sarcoma, and follicular lymphoma. (uthscsa.edu)
Patients either received 1 additional cycle of ABVD with involved-node radiation therapy (INRT) regardless of PET results (standard arm) or stratified to receive additional ABVD in PET negative patients or escalated (e)BEACOPP (bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine (or oncovin), procarbazine, prednisolone) with INRT in PET positive patients. (nature.com)
The combination of cyclophosphamide, vincristine, and prednisone (CVP) is another regimen. (healthline.com)
One month later those patients still in remission received six cycles of consolidation therapy with MACHO (cyclophosphamide 650 mg/m 2 doxorubicin 40 mg/m 2 vincristine 2 mg all intravenously on day 1 with prednisone 100 mg/m 2 orally daily on days 1-5. (elsevier.com)
Planned to receive treatment with 6 cycles of standard rituximab, cyclophosphamide, doxorubicin hydrochloride, vincristine, and prednisone (R-CHOP) per investigator determination. (who.int)
Standard of care Srituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone plus second-line salvage therapy ± autologous stem-cell transplant). (formularywatch.com)
The aim of this study was to report on the preliminary efficacy and safety of a metronomic vincristine/cyclophosphamide/methotrexate/valproic acid regimen given to children with refractory cancer of various tumor types or with a very advanced disease. (metronomics.org)
This prospective, single-center study evaluated the use of a metronomics protocol, consisting of a first cycle of weekly vincristine 1.5 mg/m 2 (days: 1, 8, 15 and 22), daily cyclophosphamide 25 mg/m 2 (days: 1-21), twice weekly methotrexate 15 mg/m² (days: 21-42) and daily valproic acid (30 mg/kg/d) followed by a 1-week break. (metronomics.org)

To determine the efficacy of Stealth liposomal doxorubicin hydrochloride (DOX-SL) in the treatment of moderate to severe AIDS-related Kaposi's sarcoma (KS) by comparison with the established therapy BV (bleomycin/vincristine). (clinicaltrials.gov)
Lenalidomide plus Dexamethasone (Len-Dex) and VAD (Vincristine, Doxorubicin and Dexamethasone) regimen are the two common drug therapies involved in the treatment of Multiple myeloma. (ijpsr.com)
This is vincristine , etoposide , prednisolone and doxorubicin . (cancerresearchuk.org)

Vincristine and also prednisone adjusts cell phone and also exosomal miR-181a appearance in different ways inside the very first time diagnosed and also the relapsed leukemia N tissues. (checkpointsignaling.com)
During the initial phase, vincristine and prednisone are used. (medicinalplants.us)
or cytarabine, vincristine, and prednisone are the combinations of agents employed. (medicinalplants.us)

The addition of cyclosporine in combination with chemotherapy regimen of carboplatin, etoposide, and vincristine reportedly have showed enhanced efficacy of chemotherapy. (medscape.com)

Each mL of sterile aqueous solution contains vincristine sulfate 1 mg. (medbroadcast.com)
Withdraw the solution of Vincristine Sulfate Injection, USP into an accurate dry syringe, measuring the dose carefully. (heethealthcare.co.in)
In vincristine induced neuropathy model, Vincristine sulfate (50 μg/kg i.p.) for 10 consecutive days was administered to induce neuropathy in rats with EP for 14 days. (ijnpnd.com)
Cytogenetic effects of vincristine sulfate and ethylene dibromide in human peripheral lymphocytes: micronucleus analysis. (cdc.gov)
Changes in the expression of immunofluorescent staining of kinetochore were determined to investigate a possible mechanism for micronuclei formation using human antikinetochore primary antibodies and fluoresceinated goat antihuman immunoglobulin-G. Vincristine- sulfate at 0.01microg/ml and mitomycin-C (MMC) at 0.04microg/ml were used as positive controls. (cdc.gov)
The frequency of KC+ micronucleated cells was similar to that (68.2%) induced by vincristine-sulfate. (cdc.gov)
Since both condensates induced KC+ micronuclei to the same extent as vincristine-sulfate, a compound known to interfere with microtubule assembly by binding to free tubulin, the aneuploidic activity of the two condensates may involve blockage of spindle assembly through an interaction with tubulin. (cdc.gov)

Vincristine (Oncovin) is used to treat malignant cancers of the lymphoid and blood systems. (californiapetpharmacy.com)

Vincristine should be given only under the supervision of a doctor with experience in the use of chemotherapy medications. (medlineplus.gov)
Vincristine is used in combination with other chemotherapy drugs to treat certain types of leukemia (cancer of the white blood cells), including acute myeloid leukemia (AML, ANLL) and acute lymphoblastic leukemia (ALL), Hodgkin's lymphoma (Hodgkin's disease), and non-Hodgkin's lymphoma (types of cancer that begin in a type of white blood cells that normally fights infection). (medlineplus.gov)
Vincristine is also used in combination with other chemotherapy drugs to treat Wilms tumor (a type of kidney cancer that occurs in children), neuroblastoma (a cancer that begins in nerve cells and occurs mainly in children), and rhabdomyosarcoma (cancer that forms in muscles in children). (medlineplus.gov)
Vincristine is a cytotoxic chemotherapy used to treat hematologic malignancies and certain brain and lung tumors. (medpagetoday.com)
Vincristine (VCR) is a vinca alkaloid that has played an important role in chemotherapy of malignant diseases for 3 decades. (biomedcentral.com)
The current study compares the antimetabolite gemcitabine with the standard care bleomycin and vincristine (BV) in the treatment of chemotherapy-naïve patients with AIDS-KS in a resource-limited setting. (uncst.go.ug)

Genetic modification of hematopoietic progenitor cells for combined resistance to 4-hydroperoxycyclophosphamide, vincristine, and daunorubicin. (cocites.com)

Vinblastine or Vincristine? (uab.edu)
Examples of essential plant-based anti-cancer compounds include podophyllotoxin analogs, taxanes, vinblastine, and vincristine. (biotechnologycommunity.com)
Vinblastine and vincristine require 500 and 2000 kg respectively of dried C. roseus leaves to synthesize 1 g of active product, which could treat approximately 10 patients. (biotechnologycommunity.com)
After vinblastine and vincristine received Food and Drug Administration (FDA) approval in the early 1960s, approaches to synthesising them using partially chemical methods were explored. (biotechnologycommunity.com)
The FDA included vinblastine and vincristine on its "drugs with shortages" list for 2019-2020. (biotechnologycommunity.com)

It is important for you to tell your doctor how you are feeling during your treatment with vincristine injection. (medlineplus.gov)
Your doctor may tell you to take a stool softener or laxative to help prevent constipation during your treatment with vincristine injection. (medlineplus.gov)
tell your doctor and pharmacist if you are allergic to vincristine, any other medications, or any of the ingredients in vincristine injection. (medlineplus.gov)
Your doctor may not want you to receive vincristine injection. (medlineplus.gov)
the other is the vincristine injection problem. (medpagetoday.com)
Call your doctor for instructions if you miss an appointment for your vincristine liposome injection. (uofmhealth.org)
The concentration of Vincristine Sulphate Injection is 1 mg/mL. (heethealthcare.co.in)
Accidental injection and resulting death are prevented when vincristine is diluted within an intravenous drip bag and not put into a syringe. (theoncologypharmacist.com)

We are back at our weekly vincristine dose, one this week and again next week before our next hospital admission. (projectsubmarine.net)

If you miss an appointment to receive vincristine, contact your doctor as soon as possible to reschedule your appointment. (medbroadcast.com)

Vincristine liposome is used to treat a type of blood cancer called Philadelphia chromosome negative acute lymphoblastic leukemia (ALL). (uofmhealth.org)
We describe a child with acute lymphoblastic leukemia who developed vincristine-induced bilateral vocal cord paralysis. (who.int)

It was at Stanford in 2005 that he provided care for the NHL patient, Christopher Wibeto, who was transferred to Carlson's care following the incorrectly administered dose of vincristine at another institution. (medpagetoday.com)
The recommended dose and dosing schedule of vincristine varies according to the specific type of cancer being treated, the response to therapy, and the other drugs or treatments being used. (medbroadcast.com)
Vincristine caused a dose dependent increase in PCE micronuclei frequency at the 6, 12, 24, and 48 hour sampling points. (cdc.gov)

In vincristine and cisplatin induced neuropathy models, co-administration of EP 100 mg/kg significantly attenuated reduction of nociceptive threshold in tail heat immersion test and threshold in paw pressure along with the increased score in the acetone drop test. (ijnpnd.com)
Therefore, with support from the literature and data in hand it seems quite evident that EP 100 mg/kg exerted its bene﫿cial effects in vincristine and cisplatin induced peripheral neuropathic pain. (ijnpnd.com)
Bansode VJ, Vyawahare NS, Munjal NB, Gore PN, Amrutkar PS, Sontakke SR. Neuroprotective effect of ethyl pyruvate in vincristine and cisplatin induced neuropathic pain. (ijnpnd.com)

What is the most important information I should know about vincristine liposome? (uofmhealth.org)
What is vincristine liposome? (uofmhealth.org)
Vincristine liposome is given after at least two other cancer treatments did not work or have stopped working. (uofmhealth.org)
Vincristine liposome may also be used for purposes not listed in this medication guide. (uofmhealth.org)
What should I discuss with my healthcare provider before receiving vincristine liposome? (uofmhealth.org)
You should not use vincristine liposome if you are allergic to it, or if you have Charcot-Marie-Tooth syndrome or other conditions that cause damage to myelin (protective covering of the nerves in your brain and spinal cord). (uofmhealth.org)
Vincristine liposome may harm an unborn baby. (uofmhealth.org)
You should not breastfeed while using vincristine liposome. (uofmhealth.org)
How is vincristine liposome given? (uofmhealth.org)
Vincristine liposome is given as an infusion into a vein, usually once a week. (uofmhealth.org)
Tell your caregivers if you feel any burning, pain, or swelling around the IV needle when vincristine liposome is injected. (uofmhealth.org)
Vincristine liposome can cause severe constipation. (uofmhealth.org)
Vincristine liposome can lower your blood cell counts. (uofmhealth.org)
What should I avoid while receiving vincristine liposome? (uofmhealth.org)
What are the possible side effects of vincristine liposome? (uofmhealth.org)
What other drugs will affect vincristine liposome? (uofmhealth.org)

While Dr Carlson was an oncologist at Stanford University, Christopher Wibeto was transferred to his care after having vincristine incorrectly administered at another institution. (theoncologypharmacist.com)

History of prior systemic anti-lymphoma therapy for diagnosed diffuse large b-cell lymphoma (DLBCL) including any definitive radiotherapy with curative intent] other than corticosteroids with or without vincristine during prephase treatment, or non-curative intent palliative radiotherapy with the stipulation that radiated lesions cannot be selected as target lesion for response assessment. (who.int)

Specifically, we increased the titers of 1-hexadecanol, pyrrolnitrin, and pacidamycin D, found novel routes to the enediyne warhead underlying powerful antimicrobials, established a cell-free system for monoterpene production, produced an intermediate toward vincristine biosynthesis, and encoded 7802 individually retrievable pathways to 540 bisindoles in a DNA pool. (nih.gov)

Vincristine manufacturers and pharmacists have been issuing warning labels, but when an error is made it is most likely to occur during the administration stage. (medpagetoday.com)
At the beginning of October, pharmacists at COG member institutions raised concerns about the ability to obtain vincristine. (seniorwomen.com)

If vincristine is mistakenly injected into the spine, it is almost always fatal within a week. (medpagetoday.com)
If vincristine is mistakenly in--jected into the spine, it is uniformly fatal, as described by speakers at an NCCN press briefing that was intended to increase awareness about this rare but serious and preventable drug safety issue. (theoncologypharmacist.com)

COG quickly contacted Pfizer/Hospira, now the sole supplier of vincristine in the United States, and was told that Pfizer/Hospira was experiencing a shortage of drug due to a manufacturing delay. (seniorwomen.com)

Patients with true ITP refractory to splenectomy and short-term treatment with adrenocortical steroids may respond to Vincristine but the medicinal product is not recommended as primary treatment of this disorder. (heethealthcare.co.in)
Recommended weekly doses of Vincristine given for 3 to 4 weeks have produced permanent remissions in some patients. (heethealthcare.co.in)
Patients who have shown signs of hypersensitivity to Vincristine or to any of the excipients. (heethealthcare.co.in)
No major early organ toxicity, including vincristine-reIated toxicity, was recorded, The overall 3-year EFS estimate (95% CL) was 538% (42-66%): in particular, 58.2% (40-76%) for AlloBMT and 27.6% (9-46%) for ABMT patients who experienced a marrow relapse before transplant. (elsevier.com)
Patients and Methods: During two consecutive trials of the United Kingdom Children's Cancer Study Group (UKW2 and UKW3, 1986 to 2001), 242 children with stage I FH Wilms' tumor were treated with immediate nephrectomy followed by 10 weekly injections of vincristine 1.5 mg/m(2). (icr.ac.uk)
Vincristine has been proven hazardous and should be avoided by all CMT patients, including those with no symptoms. (cmtausa.org)

Members of the Children's Oncology Group strongly believe that every child with cancer whose treatment requires vincristine should receive the drug as scheduled, and that a situation that requires rationing of drug is unacceptable. (seniorwomen.com)
IMSEAR at SEARO: Bilateral vocal cord paralysis following treatment with vincristine. (who.int)
Naithani R, Dolai TK, Kumar R. Bilateral vocal cord paralysis following treatment with vincristine. (who.int)
Antimicrotubule agent vincristine (VCR) has long been known as an alternative treatment for frequent relapse nephrotic syndrome and steroid-dependent nephrotic syndrome (SDNS). (biomedcentral.com)
Purpose : To identify clinical prognostic factors in children with stage 1, favorable histology (FH) Wilms' tumor treated with vincristine monochemotherapy after immediate nephrectomy to define subgroups for consideration of further reduction in treatment intensity. (icr.ac.uk)
Conclusion: Treatment for stage I FH Wilms' tumor is generally successful using vincristine monotherapy after immediate nephrectomy, and therefore, the risks of dactinomycin hepatopathy can be avoided. (icr.ac.uk)

Vincristine is used alone or in combination with other antineoplastic medications to treat many different types of cancer , including leukemia (cancer of white blood cells), lymphoma (cancer of the lymph cells), breast cancer, lung cancer, malignant melanoma, cancer of the cervix, colorectal cancer, and Wilms' tumor. (medbroadcast.com)
Lymphoma, Mast Cell Tumors, and Transmissible Venereal Tumors often include vincristine in their protocols. (californiapetpharmacy.com)

Vincristine is in a class of medications called vinca alkaloids. (medlineplus.gov)
Vincristine belongs to the group of cancer-fighting medications known as antineoplastics . (medbroadcast.com)

Vincristine is used in hematologic and nonhematologic malignancies. (medscape.com)

Induction of micronuclei in bone marrow by triethylenemelamine (51183) (TEM), mitomycin-C (50077) (MMC), dimethylbenzanthracene (57976) (DMBA), and vincristine (57227) was studied in rats. (cdc.gov)
The authors conclude that TEM, vincristine, MMC, and DMBA induce micronuclei in rat bone marrow. (cdc.gov)

Vincristine comes as a solution (liquid) to be injected intravenously (into a vein) by a doctor or nurse in a medical facility. (medlineplus.gov)

Vincristine should be administered only into a vein. (medlineplus.gov)
Vincristine is injected into a vein through a specially prepared site on your skin that has been prepared for this purpose. (medbroadcast.com)

Her next pulse of Decadron is in 2 weeks as well as a spinal tap, and Vincristine. (abbyupdate.com)

Vincristine is chiefly used as one drug in multi-drug combination protocols against lymphoid and round cell tumors. (californiapetpharmacy.com)
Many agents used in combination with vincristine are delivered intrathe-cally. (theoncologypharmacist.com)

As Chair of the Children's Oncology Group (COG) , I am sending this letter to the childhood cancer community to share information we have related to the current vincristine drug shortage, summarize steps we understand are being taken to help resolve the shortage, and to propose an approach that would benefit from an advocacy effort to help address the ongoing challenge of drug shortages that directly impact children with cancer. (seniorwomen.com)

As well as interfering with the genetic material DNA of cancer cells, vincristine can interfere with some of your normal cells. (medbroadcast.com)

A Case of Resolved Vincristine-Induced Constipation Following Osteopat" by Jennifer A. Belsky, Kimberly Wolf et al. (touro.edu)

PHILADELPHIA -- A medical safety issue that's been around for several decades finally became the focus of a campaign led by the National Comprehensive Cancer Network (NCCN) when the organization launched " Just Bag It: The NCCN Campaign for Safe Vincristine Handling in a Mini IV-Drip Bag " on Thursday. (medpagetoday.com)
In an effort to save lives related to the accidental intrathecal dosing of vincristine, the National Comprehensive Cancer Network (NCCN) has launched a program called "Just Bag It: The NCCN Campaign for Safe Handling of Vincristine. (theoncologypharmacist.com)

Vincristine may cause hair loss, vomiting, nausea or diarrhea. (californiapetpharmacy.com)

For the following cycles, vincristine was administrated only at week 1 and 5 of the cycle. (metronomics.org)

The other supplier of vincristine in the US, Teva Pharmaceuticals, made a "business decision" and stopped supplying drug to the US in July of 2019. (seniorwomen.com)
vinCRIStine is a topic covered in the Davis's Drug Guide . (drugguide.com)
Davis's Drug Guide - OLD - USE 2.0 , www.drugguide.com/ddo/view/Davis-Drug-Guide/51789/all/vinCRIStine. (drugguide.com)
2023. https://www.drugguide.com/ddo/view/Davis-Drug-Guide/51789/all/vinCRIStine. (drugguide.com)

Anatomy8

Organisms4

Diseases78

Chemicals and Drugs95

Analytical, Diagnostic and Therapeutic Techniques and Equipment49

Phenomena and Processes23

Technology, Industry, Agriculture1

Information Science1

Health Care14

Prednisone in MOPP chemotherapy for Hodgkin's disease. (1/3052)

Electronic volume analysis of L1210 chemotherapy. (2/3052)

Analysis of the effects of food and of digestive secretions on the small intestine of the rat. 1. Mucosal morphology and epithelial replacement. (3/3052)

Can we cure indolent lymphomas? (4/3052)

Topotecan versus cyclophosphamide, doxorubicin, and vincristine for the treatment of recurrent small-cell lung cancer. (5/3052)

Phase I study of liposomal vincristine. (6/3052)

Early harvest and late transplantation as an effective therapeutic strategy in multiple myeloma. (7/3052)

Progressive multifocal leukoencephalopathy after autologous bone marrow transplantation and alpha-interferon immunotherapy. (8/3052)

Doxorubicin

Cyclophosphamide

Antineoplastic Combined Chemotherapy Protocols

Etoposide

Lomustine

Vinca Alkaloids

Antineoplastic Agents, Phytogenic

Bleomycin

Vinblastine

Methotrexate

P-Glycoprotein

Drug Resistance

Antibodies, Monoclonal, Murine-Derived

Leukemia P388

Lymphoma, Non-Hodgkin

Asparaginase

Antineoplastic Agents

Combined Modality Therapy

Daunorubicin

Drug Resistance, Multiple

Prednisolone

Lymphoma, Large B-Cell, Diffuse

Rhabdomyosarcoma

Drug Administration Schedule

Remission Induction

Cytarabine

Precursor Cell Lymphoblastic Leukemia-Lymphoma

Hodgkin Disease

Dactinomycin

Melphalan

Ifosfamide

Oligodendroglioma

Treatment Outcome

Dexamethasone

Verapamil

Disease-Free Survival

Carcinoma, Small Cell

Dacarbazine

Drug Resistance, Neoplasm

Catharanthus

Survival Analysis

Vindesine

Leukemia, Lymphoid

Cisplatin

Teniposide

Survival Rate

Colchicine

Semustine

Podophyllotoxin

Chlorambucil

Mitoxantrone

Leukemia L1210

Sarcoma, Ewing

Multiple Myeloma

Wilms Tumor

KB Cells

Tumor Cells, Cultured

Antibiotics, Antineoplastic

Multidrug Resistance-Associated Proteins

Nimustine

Carmustine

Lymphoma, Follicular

Drug Screening Assays, Antitumor

Dose-Response Relationship, Drug

Neoplasm Staging

Drug Synergism

Brain Neoplasms

Prognosis

Peripheral Nervous System Diseases

Lymphoma, B-Cell

Lymphoma

Liposomes

Cell Survival

Medulloblastoma

Antimitotic Agents

Paclitaxel

Time Factors

6-Mercaptopurine

Mesna

Astrocytoma