Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.
Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to form the active aldophosphamide. It has been used in the treatment of LYMPHOMA and LEUKEMIA. Its side effect, ALOPECIA, has been used for defleecing sheep. Cyclophosphamide may also cause sterility, birth defects, mutations, and cancer.
The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. The drugs need not be in the same dosage form.
A semisynthetic derivative of PODOPHYLLOTOXIN that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitotic phase of cell division, and lead to cell death. Etoposide acts primarily in the G2 and S phases of the cell cycle.
An alkylating agent of value against both hematologic malignancies and solid tumors.
A group of indole-indoline dimers which are ALKALOIDS obtained from the VINCA genus of plants. They inhibit polymerization of TUBULIN into MICROTUBULES thus blocking spindle formation and arresting cells in METAPHASE. They are some of the most useful ANTINEOPLASTIC AGENTS.
Agents obtained from higher plants that have demonstrable cytostatic or antineoplastic activity.
A complex of related glycopeptide antibiotics from Streptomyces verticillus consisting of bleomycin A2 and B2. It inhibits DNA metabolism and is used as an antineoplastic, especially for solid tumors.
Antitumor alkaloid isolated from Vinca rosea. (Merck, 11th ed.)
An antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of TETRAHYDROFOLATE DEHYDROGENASE and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA.
A 170-kDa transmembrane glycoprotein from the superfamily of ATP-BINDING CASSETTE TRANSPORTERS. It serves as an ATP-dependent efflux pump for a variety of chemicals, including many ANTINEOPLASTIC AGENTS. Overexpression of this glycoprotein is associated with multidrug resistance (see DRUG RESISTANCE, MULTIPLE).
Diminished or failed response of an organism, disease or tissue to the intended effectiveness of a chemical or drug. It should be differentiated from DRUG TOLERANCE which is the progressive diminution of the susceptibility of a human or animal to the effects of a drug, as a result of continued administration.
Antibodies obtained from a single clone of cells grown in mice or rats.
An experimental lymphocytic leukemia originally induced in DBA/2 mice by painting with methylcholanthrene.
Any of a group of malignant tumors of lymphoid tissue that differ from HODGKIN DISEASE, being more heterogeneous with respect to malignant cell lineage, clinical course, prognosis, and therapy. The only common feature among these tumors is the absence of giant REED-STERNBERG CELLS, a characteristic of Hodgkin's disease.
A hydrolase enzyme that converts L-asparagine and water to L-aspartate and NH3. EC 3.5.1.1.
Substances that inhibit or prevent the proliferation of NEOPLASMS.
The treatment of a disease or condition by several different means simultaneously or sequentially. Chemoimmunotherapy, RADIOIMMUNOTHERAPY, chemoradiotherapy, cryochemotherapy, and SALVAGE THERAPY are seen most frequently, but their combinations with each other and surgery are also used.
A very toxic anthracycline aminoglycoside antineoplastic isolated from Streptomyces peucetius and others, used in treatment of LEUKEMIA and other NEOPLASMS.
Simultaneous resistance to several structurally and functionally distinct drugs.
A glucocorticoid with the general properties of the corticosteroids. It is the drug of choice for all conditions in which routine systemic corticosteroid therapy is indicated, except adrenal deficiency states.
Malignant lymphoma composed of large B lymphoid cells whose nuclear size can exceed normal macrophage nuclei, or more than twice the size of a normal lymphocyte. The pattern is predominantly diffuse. Most of these lymphomas represent the malignant counterpart of B-lymphocytes at midstage in the process of differentiation.
A malignant solid tumor arising from mesenchymal tissues which normally differentiate to form striated muscle. It can occur in a wide variety of sites. It is divided into four distinct types: pleomorphic, predominantly in male adults; alveolar (RHABDOMYOSARCOMA, ALVEOLAR), mainly in adolescents and young adults; embryonal (RHABDOMYOSARCOMA, EMBRYONAL), predominantly in infants and children; and botryoidal, also in young children. It is one of the most frequently occurring soft tissue sarcomas and the most common in children under 15. (From Dorland, 27th ed; Holland et al., Cancer Medicine, 3d ed, p2186; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, pp1647-9)
Time schedule for administration of a drug in order to achieve optimum effectiveness and convenience.
Therapeutic act or process that initiates a response to a complete or partial remission level.
A pyrimidine nucleoside analog that is used mainly in the treatment of leukemia, especially acute non-lymphoblastic leukemia. Cytarabine is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA. Its actions are specific for the S phase of the cell cycle. It also has antiviral and immunosuppressant properties. (From Martindale, The Extra Pharmacopoeia, 30th ed, p472)
A neoplasm characterized by abnormalities of the lymphoid cell precursors leading to excessive lymphoblasts in the marrow and other organs. It is the most common cancer in children and accounts for the vast majority of all childhood leukemias.
A malignant disease characterized by progressive enlargement of the lymph nodes, spleen, and general lymphoid tissue. In the classical variant, giant usually multinucleate Hodgkin's and REED-STERNBERG CELLS are present; in the nodular lymphocyte predominant variant, lymphocytic and histiocytic cells are seen.
A compound composed of a two CYCLIC PEPTIDES attached to a phenoxazine that is derived from STREPTOMYCES parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also declines after dactinomycin therapy. (From AMA Drug Evaluations Annual, 1993, p2015)
An alkylating nitrogen mustard that is used as an antineoplastic in the form of the levo isomer - MELPHALAN, the racemic mixture - MERPHALAN, and the dextro isomer - MEDPHALAN; toxic to bone marrow, but little vesicant action; potential carcinogen.
Positional isomer of CYCLOPHOSPHAMIDE which is active as an alkylating agent and an immunosuppressive agent.
A relatively slow-growing glioma that is derived from oligodendrocytes and tends to occur in the cerebral hemispheres, thalamus, or lateral ventricle. They may present at any age, but are most frequent in the third to fifth decades, with an earlier incidence peak in the first decade. Histologically, these tumors are encapsulated, relatively avascular, and tend to form cysts and microcalcifications. Neoplastic cells tend to have small round nuclei surrounded by unstained nuclei. The tumors may vary from well-differentiated to highly anaplastic forms. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, p2052; Adams et al., Principles of Neurology, 6th ed, p655)
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
An anti-inflammatory 9-fluoro-glucocorticoid.
A calcium channel blocker that is a class IV anti-arrhythmia agent.
Period after successful treatment in which there is no appearance of the symptoms or effects of the disease.
An anaplastic, highly malignant, and usually bronchogenic carcinoma composed of small ovoid cells with scanty neoplasm. It is characterized by a dominant, deeply basophilic nucleus, and absent or indistinct nucleoli. (From Stedman, 25th ed; Holland et al., Cancer Medicine, 3d ed, p1286-7)
An antineoplastic agent. It has significant activity against melanomas. (from Martindale, The Extra Pharmacopoeia, 31st ed, p564)
Resistance or diminished response of a neoplasm to an antineoplastic agent in humans, animals, or cell or tissue cultures.
A plant genus of the family Apocynaceae. It is the source of VINCA ALKALOIDS, used in leukemia chemotherapy.
A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.
Vinblastine derivative with antineoplastic activity against CANCER. Major side effects are myelosuppression and neurotoxicity. Vindesine is used extensively in chemotherapy protocols (ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS).
Leukemia associated with HYPERPLASIA of the lymphoid tissues and increased numbers of circulating malignant LYMPHOCYTES and lymphoblasts.
An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle.
A semisynthetic derivative of PODOPHYLLOTOXIN that exhibits antitumor activity. Teniposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent cells from entering into the mitotic phase of the cell cycle, and lead to cell death. Teniposide acts primarily in the G2 and S phases of the cycle.
The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.
A major alkaloid from Colchicum autumnale L. and found also in other Colchicum species. Its primary therapeutic use is in the treatment of gout, but it has been used also in the therapy of familial Mediterranean fever (PERIODIC DISEASE).
4-Methyl derivative of LOMUSTINE; (CCNU). An antineoplastic agent which functions as an alkylating agent.
A lignan (LIGNANS) found in PODOPHYLLIN resin from the roots of PODOPHYLLUM plants. It is a potent spindle poison, toxic if taken internally, and has been used as a cathartic. It is very irritating to skin and mucous membranes, has keratolytic actions, has been used to treat warts and keratoses, and may have antineoplastic properties, as do some of its congeners and derivatives.
A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
An anthracenedione-derived antineoplastic agent.
A malignant tumor of the bone which always arises in the medullary tissue, occurring more often in cylindrical bones. The tumor occurs usually before the age of 20, about twice as frequently in males as in females.
A malignancy of mature PLASMA CELLS engaging in monoclonal immunoglobulin production. It is characterized by hyperglobulinemia, excess Bence-Jones proteins (free monoclonal IMMUNOGLOBULIN LIGHT CHAINS) in the urine, skeletal destruction, bone pain, and fractures. Other features include ANEMIA; HYPERCALCEMIA; and RENAL INSUFFICIENCY.
A malignant kidney tumor, caused by the uncontrolled multiplication of renal stem (blastemal), stromal (STROMAL CELLS), and epithelial (EPITHELIAL CELLS) elements. However, not all three are present in every case. Several genes or chromosomal areas have been associated with Wilms tumor which is usually found in childhood as a firm lump in a child's side or ABDOMEN.
This line KB is now known to be a subline of the ubiquitous KERATIN-forming tumor cell line HeLa. It was originally thought to be derived from an epidermal carcinoma of the mouth, but was subsequently found, based on isoenzyme analysis, HeLa marker chromosomes, and DNA fingerprinting, to have been established via contamination by HELA CELLS. The cells are positive for keratin by immunoperoxidase staining. KB cells have been reported to contain human papillomavirus18 (HPV-18) sequences.
Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.
Chemical substances, produced by microorganisms, inhibiting or preventing the proliferation of neoplasms.
A sequence-related subfamily of ATP-BINDING CASSETTE TRANSPORTERS that actively transport organic substrates. Although considered organic anion transporters, a subset of proteins in this family have also been shown to convey drug resistance to neutral organic drugs. Their cellular function may have clinical significance for CHEMOTHERAPY in that they transport a variety of ANTINEOPLASTIC AGENTS. Overexpression of proteins in this class by NEOPLASMS is considered a possible mechanism in the development of multidrug resistance (DRUG RESISTANCE, MULTIPLE). Although similar in function to P-GLYCOPROTEINS, the proteins in this class share little sequence homology to the p-glycoprotein family of proteins.
Antineoplastic agent especially effective against malignant brain tumors. The resistance which brain tumor cells acquire to the initial effectiveness of this drug can be partially overcome by the simultaneous use of membrane-modifying agents such as reserpine, calcium antagonists such as nicardipine or verapamil, or the calmodulin inhibitor, trifluoperazine. The drug has also been used in combination with other antineoplastic agents or with radiotherapy for the treatment of various neoplasms.
A cell-cycle phase nonspecific alkylating antineoplastic agent. It is used in the treatment of brain tumors and various other malignant neoplasms. (From Martindale, The Extra Pharmacopoeia, 30th ed, p462) This substance may reasonably be anticipated to be a carcinogen according to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (From Merck Index, 11th ed)
Malignant lymphoma in which the lymphomatous cells are clustered into identifiable nodules within the LYMPH NODES. The nodules resemble to some extent the GERMINAL CENTER of lymph node follicles and most likely represent neoplastic proliferation of lymph node-derived follicular center B-LYMPHOCYTES.
Methods of investigating the effectiveness of anticancer cytotoxic drugs and biologic inhibitors. These include in vitro cell-kill models and cytostatic dye exclusion tests as well as in vivo measurement of tumor growth parameters in laboratory animals.
The relationship between the dose of an administered drug and the response of the organism to the drug.
Methods which attempt to express in replicable terms the extent of the neoplasm in the patient.
The action of a drug in promoting or enhancing the effectiveness of another drug.
Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.
A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.
Diseases of the peripheral nerves external to the brain and spinal cord, which includes diseases of the nerve roots, ganglia, plexi, autonomic nerves, sensory nerves, and motor nerves.
A group of heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes.
A general term for various neoplastic diseases of the lymphoid tissue.
Artificial, single or multilaminar vesicles (made from lecithins or other lipids) that are used for the delivery of a variety of biological molecules or molecular complexes to cells, for example, drug delivery and gene transfer. They are also used to study membranes and membrane proteins.
The span of viability of a cell characterized by the capacity to perform certain functions such as metabolism, growth, reproduction, some form of responsiveness, and adaptability.
A malignant neoplasm that may be classified either as a glioma or as a primitive neuroectodermal tumor of childhood (see NEUROECTODERMAL TUMOR, PRIMITIVE). The tumor occurs most frequently in the first decade of life with the most typical location being the cerebellar vermis. Histologic features include a high degree of cellularity, frequent mitotic figures, and a tendency for the cells to organize into sheets or form rosettes. Medulloblastoma have a high propensity to spread throughout the craniospinal intradural axis. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2060-1)
Agents that arrest cells in MITOSIS, most notably TUBULIN MODULATORS.
A cyclodecane isolated from the bark of the Pacific yew tree, TAXUS BREVIFOLIA. It stabilizes MICROTUBULES in their polymerized form leading to cell death.
Elements of limited time intervals, contributing to particular results or situations.
An antimetabolite antineoplastic agent with immunosuppressant properties. It interferes with nucleic acid synthesis by inhibiting purine metabolism and is used, usually in combination with other drugs, in the treatment of or in remission maintenance programs for leukemia.
A sulfhydryl compound used to prevent urothelial toxicity by inactivating metabolites from ANTINEOPLASTIC AGENTS, such as IFOSFAMIDE or CYCLOPHOSPHAMIDE.
Neoplasms of the brain and spinal cord derived from glial cells which vary from histologically benign forms to highly anaplastic and malignant tumors. Fibrillary astrocytomas are the most common type and may be classified in order of increasing malignancy (grades I through IV). In the first two decades of life, astrocytomas tend to originate in the cerebellar hemispheres; in adults, they most frequently arise in the cerebrum and frequently undergo malignant transformation. (From Devita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2013-7; Holland et al., Cancer Medicine, 3d ed, p1082)
Tumors or cancer of the LUNG.
Slender, cylindrical filaments found in the cytoskeleton of plant and animal cells. They are composed of the protein TUBULIN and are influenced by TUBULIN MODULATORS.
A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)
A microtubule subunit protein found in large quantities in mammalian brain. It has also been isolated from SPERM FLAGELLUM; CILIA; and other sources. Structurally, the protein is a dimer with a molecular weight of approximately 120,000 and a sedimentation coefficient of 5.8S. It binds to COLCHICINE; VINCRISTINE; and VINBLASTINE.
The conjugation product of LEUKOTRIENE A4 and glutathione. It is the major arachidonic acid metabolite in macrophages and human mast cells as well as in antigen-sensitized lung tissue. It stimulates mucus secretion in the lung, and produces contractions of nonvascular and some VASCULAR SMOOTH MUSCLE. (From Dictionary of Prostaglandins and Related Compounds, 1990)
Alkylating antineoplastic toxic to bone marrow; used in breast cancer, also in combination with other drugs.
Primary or metastatic neoplasms of the CEREBELLUM. Tumors in this location frequently present with ATAXIA or signs of INTRACRANIAL HYPERTENSION due to obstruction of the fourth ventricle. Common primary cerebellar tumors include fibrillary ASTROCYTOMA and cerebellar HEMANGIOBLASTOMA. The cerebellum is a relatively common site for tumor metastases from the lung, breast, and other distant organs. (From Okazaki & Scheithauer, Atlas of Neuropathology, 1988, p86 and p141)
Leukemia induced experimentally in animals by exposure to leukemogenic agents, such as VIRUSES; RADIATION; or by TRANSPLANTATION of leukemic tissues.
Forms to which substances are incorporated to improve the delivery and the effectiveness of drugs. Drug carriers are used in drug-delivery systems such as the controlled-release technology to prolong in vivo drug actions, decrease drug metabolism, and reduce drug toxicity. Carriers are also used in designs to increase the effectiveness of drug delivery to the target sites of pharmacological actions. Liposomes, albumin microspheres, soluble synthetic polymers, DNA complexes, protein-drug conjugates, and carrier erythrocytes among others have been employed as biodegradable drug carriers.
An antineoplastic agent used to treat ovarian cancer. It works by inhibiting DNA TOPOISOMERASES, TYPE I.
A mixture of six synthetic oligopeptides, each containing MELPHALAN. It is used as a broad-spectrum antineoplastic due to its alkylating and antimetabolic actions but, is toxic to bone marrow, gastrointestinal system and vasculature.
Benign and malignant neoplastic processes that arise from or secondarily involve the brain, spinal cord, or meninges.
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
The local recurrence of a neoplasm following treatment. It arises from microscopic cells of the original neoplasm that have escaped therapeutic intervention and later become clinically visible at the original site.
An organoplatinum compound that possesses antineoplastic activity.
The return of a sign, symptom, or disease after a remission.
The application of probability and statistical methods to calculate the risk of occurrence of any event, such as onset of illness, recurrent disease, hospitalization, disability, or death. It may include calculation of the anticipated money costs of such events and of the premiums necessary to provide for payment of such costs.
Primary and metastatic (secondary) tumors of the brain located above the tentorium cerebelli, a fold of dura mater separating the CEREBELLUM and BRAIN STEM from the cerebral hemispheres and DIENCEPHALON (i.e., THALAMUS and HYPOTHALAMUS and related structures). In adults, primary neoplasms tend to arise in the supratentorial compartment, whereas in children they occur more frequently in the infratentorial space. Clinical manifestations vary with the location of the lesion, but SEIZURES; APHASIA; HEMIANOPSIA; hemiparesis; and sensory deficits are relatively common features. Metastatic supratentorial neoplasms are frequently multiple at the time of presentation.
Disorders of the blood and blood forming tissues.
A plant genus of the family ONAGRACEAE. Members contain oenotheins.
A neoplasm of prolymphocytes affecting the blood, bone marrow, and spleen. It is characterized by prolymphocytes exceeding 55% of the lymphoid cells in the blood and profound splenomegaly.
A subnormal level of BLOOD PLATELETS.
Transplantation of an individual's own tissue from one site to another site.
A class of drugs that differs from other alkylating agents used clinically in that they are monofunctional and thus unable to cross-link cellular macromolecules. Among their common properties are a requirement for metabolic activation to intermediates with antitumor efficacy and the presence in their chemical structures of N-methyl groups, that after metabolism, can covalently modify cellular DNA. The precise mechanisms by which each of these drugs acts to kill tumor cells are not completely understood. (From AMA, Drug Evaluations Annual, 1994, p2026)
Works about pre-planned studies of the safety, efficacy, or optimum dosage schedule (if appropriate) of one or more diagnostic, therapeutic, or prophylactic drugs, devices, or techniques selected according to predetermined criteria of eligibility and observed for predefined evidence of favorable and unfavorable effects. This concept includes clinical trials conducted both in the U.S. and in other countries.
A form of undifferentiated malignant LYMPHOMA usually found in central Africa, but also reported in other parts of the world. It is commonly manifested as a large osteolytic lesion in the jaw or as an abdominal mass. B-cell antigens are expressed on the immature cells that make up the tumor in virtually all cases of Burkitt lymphoma. The Epstein-Barr virus (HERPESVIRUS 4, HUMAN) has been isolated from Burkitt lymphoma cases in Africa and it is implicated as the causative agent in these cases; however, most non-African cases are EBV-negative.
An anthracycline which is the 4'-epi-isomer of doxorubicin. The compound exerts its antitumor effects by interference with the synthesis and function of DNA.
The exposure of the head to roentgen rays or other forms of radioactivity for therapeutic or preventive purposes.
A glycoprotein of MW 25 kDa containing internal disulfide bonds. It induces the survival, proliferation, and differentiation of neutrophilic granulocyte precursor cells and functionally activates mature blood neutrophils. Among the family of colony-stimulating factors, G-CSF is the most potent inducer of terminal differentiation to granulocytes and macrophages of leukemic myeloid cell lines.
The long-term (minutes to hours) administration of a fluid into the vein through venipuncture, either by letting the fluid flow by gravity or by pumping it.
A cell line derived from cultured tumor cells.
Antibodies produced by a single clone of cells.
A decrease in the number of NEUTROPHILS found in the blood.
FEVER accompanied by a significant reduction in NEUTROPHIL count associated with CHEMOTHERAPY.
Neurologic disorders caused by exposure to toxic substances through ingestion, injection, cutaneous application, or other method. This includes conditions caused by biologic, chemical, and pharmaceutical agents.
A therapeutic approach, involving chemotherapy, radiation therapy, or surgery, after initial regimens have failed to lead to improvement in a patient's condition. Salvage therapy is most often used for neoplastic diseases.
A form of non-Hodgkin lymphoma having a usually diffuse pattern with both small and medium lymphocytes and small cleaved cells. It accounts for about 5% of adult non-Hodgkin lymphomas in the United States and Europe. The majority of mantle-cell lymphomas are associated with a t(11;14) translocation resulting in overexpression of the CYCLIN D1 gene (GENES, BCL-1).
Genes for MEMBRANE TRANSPORT PROTEINS that confer resistance to toxic compounds. Several superfamilies of these multidrug export proteins are known and found in both prokaryotes and eukaryotes.
Tumors or cancer of the RETINA.
A group of closely related cyclic undecapeptides from the fungi Trichoderma polysporum and Cylindocarpon lucidum. They have some antineoplastic and antifungal action and significant immunosuppressive effects. Cyclosporins have been proposed as adjuvants in tissue and organ transplantation to suppress graft rejection.
Organic nitrogenous bases. Many alkaloids of medical importance occur in the animal and vegetable kingdoms, and some have been synthesized. (Grant & Hackh's Chemical Dictionary, 5th ed)
An anabolic steroid that has been used in the treatment of male HYPOGONADISM, delayed puberty in males, and in the treatment of breast neoplasms in women.
A process involving chance used in therapeutic trials or other research endeavor for allocating experimental subjects, human or animal, between treatment and control groups, or among treatment groups. It may also apply to experiments on inanimate objects.
Agents which affect CELL DIVISION and the MITOTIC SPINDLE APPARATUS resulting in the loss or gain of whole CHROMOSOMES, thereby inducing an ANEUPLOIDY.
Drug therapy given to augment or stimulate some other form of treatment such as surgery or radiation therapy. Adjuvant chemotherapy is commonly used in the therapy of cancer and can be administered before or after the primary treatment.
A group of malignant tumors of the nervous system that feature primitive cells with elements of neuronal and/or glial differentiation. Use of this term is limited by some authors to central nervous system tumors and others include neoplasms of similar origin which arise extracranially (i.e., NEUROECTODERMAL TUMORS, PRIMITIVE, PERIPHERAL). This term is also occasionally used as a synonym for MEDULLOBLASTOMA. In general, these tumors arise in the first decade of life and tend to be highly malignant. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, p2059)
Agents that interact with TUBULIN to inhibit or promote polymerization of MICROTUBULES.
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
A group of diseases arising from pregnancy that are commonly associated with hyperplasia of trophoblasts (TROPHOBLAST) and markedly elevated human CHORIONIC GONADOTROPIN. They include HYDATIDIFORM MOLE, invasive mole (HYDATIDIFORM MOLE, INVASIVE), placental-site trophoblastic tumor (TROPHOBLASTIC TUMOR, PLACENTAL SITE), and CHORIOCARCINOMA. These neoplasms have varying propensities for invasion and spread.
Injections made into a vein for therapeutic or experimental purposes.
B-cell lymphoid tumors that occur in association with AIDS. Patients often present with an advanced stage of disease and highly malignant subtypes including BURKITT LYMPHOMA; IMMUNOBLASTIC LARGE-CELL LYMPHOMA; PRIMARY EFFUSION LYMPHOMA; and DIFFUSE, LARGE B-CELL, LYMPHOMA. The tumors are often disseminated in unusual extranodal sites and chromosomal abnormalities are frequently present. It is likely that polyclonal B-cell lymphoproliferation in AIDS is a complex result of EBV infection, HIV antigenic stimulation, and T-cell-dependent HIV activation.
Any process by which toxicity, metabolism, absorption, elimination, preferred route of administration, safe dosage range, etc., for a drug or group of drugs is determined through clinical assessment in humans or veterinary animals.
A transplantable, poorly differentiated malignant tumor which appeared originally as a spontaneous breast carcinoma in a mouse. It grows in both solid and ascitic forms.
Radiotherapy using high-energy (megavolt or higher) ionizing radiation. Types of radiation include gamma rays, produced by a radioisotope within a teletherapy unit; x-rays, electrons, protons, alpha particles (helium ions) and heavy charged ions, produced by particle acceleration; and neutrons and pi-mesons (pions), produced as secondary particles following bombardment of a target with a primary particle.
A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)
Radiotherapy given to augment some other form of treatment such as surgery or chemotherapy. Adjuvant radiotherapy is commonly used in the therapy of cancer and can be administered before or after the primary treatment.
A drug formerly used in the treatment of angina pectoris but superseded by less hazardous drugs. Prenylamine depletes myocardial catecholamine stores and has some calcium channel blocking activity. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1406)
The fission of a CELL. It includes CYTOKINESIS, when the CYTOPLASM of a cell is divided, and CELL NUCLEUS DIVISION.
Experimental transplantation of neoplasms in laboratory animals for research purposes.
A group of 20-member macrolactones in which there are three remotely substituted pyran rings that are linked by a methylene bridge and an E-disubstituted alkene, and have geminal dimethyls at C8 and C18 carbons. Some interact with PROTEIN KINASE C.
The total amount of radiation absorbed by tissues as a result of radiotherapy.
A plant species of the family VISCACEAE, order Santalales, subclass Rosidae. This is the traditional mistletoe of literature and Christmas. Members contain viscotoxin (5 kDa basic polypeptides related to thionins), beta-galactoside- and N-acetyl-D-galactosamine-specific lectin II (60 kDa), and polysaccharides. Mistletoe lectin I is a type 2 ribosome-inactivating protein. Commercial extracts include Plenosol, Eurixor, Helixor Isorel, Iscador, and NSC 635089 (ANTINEOPLASTIC AGENTS, PHYTOGENIC).
An ansa macrolide isolated from the MAYTENUS genus of East African shrubs.
The use of IONIZING RADIATION to treat malignant NEOPLASMS and some benign conditions.
Inorganic or organic compounds that contain the basic structure RB(OH)2.
Tumors or cancer located in bone tissue or specific BONES.
A malignant tumor arising from the nuclear layer of the retina that is the most common primary tumor of the eye in children. The tumor tends to occur in early childhood or infancy and may be present at birth. The majority are sporadic, but the condition may be transmitted as an autosomal dominant trait. Histologic features include dense cellularity, small round polygonal cells, and areas of calcification and necrosis. An abnormal pupil reflex (leukokoria); NYSTAGMUS, PATHOLOGIC; STRABISMUS; and visual loss represent common clinical characteristics of this condition. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, p2104)
A type of CELL NUCLEUS division by means of which the two daughter nuclei normally receive identical complements of the number of CHROMOSOMES of the somatic cells of the species.
A malignant olfactory neuroblastoma arising from the olfactory epithelium of the superior nasal cavity and cribriform plate. It is uncommon (3% of nasal tumors) and rarely is associated with the production of excess hormones (e.g., SIADH, Cushing Syndrome). It has a high propensity for multiple local recurrences and bony metastases. (From Holland et al., Cancer Medicine, 3rd ed, p1245; J Laryngol Otol 1998 Jul;112(7):628-33)
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
An antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia.
A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
In vivo method of screening investigative anticancer drugs and biologic response modifiers for individual cancer patients. Fresh tumor tissue is implanted under the kidney capsule of immunocompetent mice or rats; gross and histological assessments follow several days after tumor treatment in situ.
The reaction of two molecular entities via oxidation usually catalyzed by a transition metal compound and involving dioxygen as the oxidant.
The soft tissue filling the cavities of bones. Bone marrow exists in two types, yellow and red. Yellow marrow is found in the large cavities of large bones and consists mostly of fat cells and a few primitive blood cells. Red marrow is a hematopoietic tissue and is the site of production of erythrocytes and granular leukocytes. Bone marrow is made up of a framework of connective tissue containing branching fibers with the frame being filled with marrow cells.
A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.
A group of highly cellular primitive round cell neoplasms which occur extracranially in soft tissue and bone and are derived from embryonal neural crest cells. These tumors occur primarily in children and adolescents and share a number of characteristics with EWING SARCOMA.
ISOQUINOLINES with a benzyl substituent.
Mice homozygous for the mutant autosomal recessive gene "scid" which is located on the centromeric end of chromosome 16. These mice lack mature, functional lymphocytes and are thus highly susceptible to lethal opportunistic infections if not chronically treated with antibiotics. The lack of B- and T-cell immunity resembles severe combined immunodeficiency (SCID) syndrome in human infants. SCID mice are useful as animal models since they are receptive to implantation of a human immune system producing SCID-human (SCID-hu) hematochimeric mice.
Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)
A nonparametric method of compiling LIFE TABLES or survival tables. It combines calculated probabilities of survival and estimates to allow for observations occurring beyond a measurement threshold, which are assumed to occur randomly. Time intervals are defined as ending each time an event occurs and are therefore unequal. (From Last, A Dictionary of Epidemiology, 1995)
A leukemia/lymphoma found predominately in children and adolescents and characterized by a high number of lymphoblasts and solid tumor lesions. Frequent sites involve LYMPH NODES, skin, and bones. It most commonly presents as leukemia.
A family of MEMBRANE TRANSPORT PROTEINS that require ATP hydrolysis for the transport of substrates across membranes. The protein family derives its name from the ATP-binding domain found on the protein.
A connective tissue disorder characterized by widespread thickening of SKIN with a cobblestone-like appearance. It is caused by proliferation of FIBROBLASTS and deposition of MUCIN in the DERMIS in the absence of thyroid disease. Most scleromyxedema cases are associated with a MONOCLONAL GAMMOPATHY, immunoglobulin IgG-lambda.
Introduction of therapeutic agents into the spinal region using a needle and syringe.
The movement of materials (including biochemical substances and drugs) through a biological system at the cellular level. The transport can be across cell membranes and epithelial layers. It also can occur within intracellular compartments and extracellular compartments.
The concentration of a compound needed to reduce population growth of organisms, including eukaryotic cells, by 50% in vitro. Though often expressed to denote in vitro antibacterial activity, it is also used as a benchmark for cytotoxicity to eukaryotic cells in culture.
A phenolphthalein that is used as a diagnostic aid in hepatic function determination.
A connective tissue neoplasm formed by proliferation of mesodermal cells; it is usually highly malignant.
A specific pair of GROUP F CHROMOSOMES of the human chromosome classification.
Diseases of any component of the brain (including the cerebral hemispheres, diencephalon, brain stem, and cerebellum) or the spinal cord.
In vivo methods of screening investigative anticancer drugs, biologic response modifiers or radiotherapies. Human tumor tissue or cells are transplanted into mice or rats followed by tumor treatment regimens. A variety of outcomes are monitored to assess antitumor effectiveness.
The complex series of phenomena, occurring between the end of one CELL DIVISION and the end of the next, by which cellular material is duplicated and then divided between two daughter cells. The cell cycle includes INTERPHASE, which includes G0 PHASE; G1 PHASE; S PHASE; and G2 PHASE, and CELL DIVISION PHASE.
The rate dynamics in chemical or physical systems.
Phenomena and pharmaceutics of compounds that inhibit the function of agonists (DRUG AGONISM) and inverse agonists (DRUG INVERSE AGONISM) for a specific receptor. On their own, antagonists produce no effect by themselves to a receptor, and are said to have neither intrinsic activity nor efficacy.
The action of a drug that may affect the activity, metabolism, or toxicity of another drug.
Established cell cultures that have the potential to propagate indefinitely.
Quaternary salts derived from tetrazoles. They are used in tests to distinguish between reducing sugars and simple aldehydes, for detection of dehydrogenase in tissues, cells, and bacteria, for determination of corticosteroids, and in color photography. (From Mall's Dictionary of Chemistry, 5th ed, p455)
The active metabolite of FOLIC ACID. Leucovorin is used principally as an antidote to FOLIC ACID ANTAGONISTS.
A fluorescent probe with low toxicity which is a potent substrate for P-glycoprotein and the bacterial multidrug efflux transporter. It is used to assess mitochondrial bioenergetics in living cells and to measure the efflux activity of P-glycoprotein in both normal and malignant cells. (Leukemia 1997;11(7):1124-30)
Malignant neoplasms composed of MACROPHAGES or DENDRITIC CELLS. Most histiocytic sarcomas present as localized tumor masses without a leukemic phase. Though the biological behavior of these neoplasms resemble lymphomas, their cell lineage is histiocytic not lymphoid.
Form of leukemia characterized by an uncontrolled proliferation of the myeloid lineage and their precursors (MYELOID PROGENITOR CELLS) in the bone marrow and other sites.
A measure of the quality of health care by assessment of unsuccessful results of management and procedures used in combating disease, in individual cases or series.
Absence of hair from areas where it is normally present.
Glycoproteins found on the membrane or surface of cells.
The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.
Tumors or cancer of the MEDIASTINUM.
An orally administered anthracycline antineoplastic. The compound has shown activity against BREAST NEOPLASMS; LYMPHOMA; and LEUKEMIA.
A malignant neoplasm occurring in young children, primarily in the liver, composed of tissue resembling embryonal or fetal hepatic epithelium, or mixed epithelial and mesenchymal tissues. (Stedman, 25th ed)
Diseases of the central and peripheral nervous system. This includes disorders of the brain, spinal cord, cranial nerves, peripheral nerves, nerve roots, autonomic nervous system, neuromuscular junction, and muscle.
Tumors or cancers of the KIDNEY.
An alkaloid isolated from the stem wood of the Chinese tree, Camptotheca acuminata. This compound selectively inhibits the nuclear enzyme DNA TOPOISOMERASES, TYPE I. Several semisynthetic analogs of camptothecin have demonstrated antitumor activity.
Tumors or cancer of the INTESTINES.
Malignant neoplasms arising in the neuroectoderm, the portion of the ectoderm of the early embryo that gives rise to the central and peripheral nervous systems, including some glial cells.
Trophoblastic growth, which may be gestational or nongestational in origin. Trophoblastic neoplasia resulting from pregnancy is often described as gestational trophoblastic disease to distinguish it from germ cell tumors which frequently show trophoblastic elements, and from the trophoblastic differentiation which sometimes occurs in a wide variety of epithelial cancers. Gestational trophoblastic growth has several forms, including HYDATIDIFORM MOLE and CHORIOCARCINOMA. (From Holland et al., Cancer Medicine, 3d ed, p1691)
Mild to moderate loss of bilateral lower extremity motor function, which may be a manifestation of SPINAL CORD DISEASES; PERIPHERAL NERVOUS SYSTEM DISEASES; MUSCULAR DISEASES; INTRACRANIAL HYPERTENSION; parasagittal brain lesions; and other conditions.

Prednisone in MOPP chemotherapy for Hodgkin's disease. (1/3052)

High remission rates have been produced by MOPP (mustine, vincristine, procarbazine, and prednisone) chemotherapy in patients with advanced Hodgkin's disease, but the prednisone component has caused adverse effects in patients who have undergone radiotherapy. The remission rates and length of remission were reviewed in 211 patients with Hodgkin's disease who received chemotherapy either with or without prednisone. In contrast to the findings of a British study, there were no significant differences in remission rates or length of remission between patients who had received prednisone and patients who had not. There were differences between the British prospective study and this retrospective one, but it is difficult to know what accounted for the substantial differences in the findings.  (+info)

Electronic volume analysis of L1210 chemotherapy. (2/3052)

The rapid analysis of in vivo chemotherapy on the L1210 ascites tumor grown in C57BL/6 X DBA/2F1 mice has been shown by means of an electronic volume analysis. The drugs were injected on the 4th day of tumor growth, and the cells in the peritoneal cavity were studied at 24-hr intervals on the 5th through 7th day. Using the electronic cell volume distributions, combined with labeling indices, cell morphology, and cell counts, it was found that the alkylating agents. 1,3-bis(2-chloroethyl)-1-nitrosourea and cyclophosphamide, at the dosages used, were more effective than the S-phase-specific drugs, palmitoyl ester of 1-beta-D-arabinofuranosylcytosine, vincristine, and methotrexate.  (+info)

Analysis of the effects of food and of digestive secretions on the small intestine of the rat. 1. Mucosal morphology and epithelial replacement. (3/3052)

A modified Roux-en-Y repositioning of rat small intestine was performed so that the proximal segment of bowel (A) received only bile and pancreastic secretions, the second (B) received food direct from the stomach, and these two segments drained into a third (C). Four to five weeks after operation, cell production was assessed by injection of vincristine into operated, sham-operated and unoperated rats, and counts of blocked metaphases were made on isolated microdissected crypts. Villus height, crypt depth, and the number of crypts per villus (crypt/villus ratio) were also measured. Most of segment A showed no significant differences from sham-operated intestine, although the normal proximo-distal gradient of villus height was abolished. At the distal end (near the anastomosis with segments B and C), crypt depth and cell production were increased. The villus height gradient in segment B was also abolished, although crypt depth and cell production were significantly increased, especially at the proximal end. Crypt/villus ratio was also increased. Segment C showed all the characteristics of small bowel promoted to a more proximal position: increased villus height, crypt depth and cell production. Increased crypt/villus ratio was also observed. These results are discussed in terms of the role of food and of digestive secretions in the control of mucosal morphology and epithelial replacement.  (+info)

Can we cure indolent lymphomas? (4/3052)

The current consensus is that indolent lymphomas are incurable disorders. There are some indications that these malignancies are potentially curable. Indeed, not all indolent lymphomas are currently incurable. For example, patients with Ann Arbor stage I-II indolent lymphomas can experience long-term disease-free survival and probable cure. Also, from the available literature data, it seems that the achievement of a molecular complete remission is a desirable objective. Patients who achieve a persistently negative PCR state seldom relapse, whereas the opposite is true for persistently positive cases. In view of its excellent correlation with disease-free survival when examined serially in multiple blood or marrow samples, the PCR technique has the potential of providing a tumor marker that can be used as an early end point for clinical trials. By serving as an early surrogate end point, PCR could play an important role in expediting the development of new treatment strategies. Whether IFN is capable of increasing the molecular complete remission rate as measured by PCR is not known. However, it is clear that from the clinical standpoint, IFN has been able to increase 2-fold the length of remission in patients with advanced indolent lymphomas. In at least two studies, this has been associated with prolongation of survival. More intensive regimens such as alternating triple therapy, when used in combination with IFN, seem to have improved the quality of remissions as judged by the PCR assay. Finally, the site where the bcl-2 breakpoint occurs seems to have clinical significance. Those follicular lymphomas with germ-line bcl-2, in our experience, have behaved more aggressively than the others, and their failure-free survival seems different from the usual indolent lymphomas and more closely resembles the large cell lymphomas. Although the biological significance of this observation is not yet understood, this group might actually constitute a prognostically different subset with a more aggressive and perhaps more curable lymphoma. Whether the plateau observed in their failure-free survival curve will be maintained with more follow-up and whether they might be a curable subset remain to be determined.  (+info)

Topotecan versus cyclophosphamide, doxorubicin, and vincristine for the treatment of recurrent small-cell lung cancer. (5/3052)

PURPOSE: Topotecan and cyclophosphamide, doxorubicin, and vincristine (CAV) were evaluated in a randomized, multicenter study of patients with small-cell lung cancer (SCLC) who had relapsed at least 60 days after completion of first-line therapy. PATIENTS AND METHODS: Patients received either topotecan (1.5 mg/m2) as a 30-minute infusion daily for 5 days every 21 days (n = 107) or CAV (cyclophosphamide 1,000 mg/m2, doxorubicin 45 mg/m2, and vincristine 2 mg) infused on day 1 every 21 days (n = 104). Eligibility included the following: bidimensionally measurable disease, Eastern Cooperative Oncology Group performance status of less than or equal to 2, and adequate marrow, liver, and renal function. Response was confirmed by blinded independent radiologic review. RESULTS: Response rate was 26 of 107 patients (24.3%) treated with topotecan and 19 of 104 patients (18.3%) treated with CAV (P = .285). Median times to progression were 13.3 weeks (topotecan) and 12.3 weeks (CAV) (P = .552). Median survival was 25.0 weeks for topotecan and 24.7 weeks for CAV (P = .795). The proportion of patients who experienced symptom improvement was greater in the topotecan group than in the CAV group for four of eight symptoms evaluated, including dyspnea, anorexia, hoarseness, and fatigue, as well as interference with daily activity (P< or =.043). Grade 4 neutropenia occurred in 37.8% of topotecan courses versus 51.4% of CAV courses (P<.001). Grade 4 thrombocytopenia and grade 3/4 anemia occurred more frequently with topotecan, occurring in 9.8% and 17.7% of topotecan courses versus 1.4% and 7.2% of CAV courses, respectively (P<.001 for both). Nonhematologic toxicities were generally grade 1 to 2 for both regimens. CONCLUSION: Topotecan was at least as effective as CAV in the treatment of patients with recurrent SCLC and resulted in improved control of several symptoms.  (+info)

Phase I study of liposomal vincristine. (6/3052)

PURPOSE: A phase I study of vincristine encapsulated inside 120-nm-diameter distearoylphosphatidylcholine-cholesterol liposomes was performed. The primary objectives were to determine the maximum-tolerated dose (MTD), recommended phase II dose, toxicity, and pharmacokinetics of liposomal vincristine (ONCO-TCS). PATIENTS AND METHODS: Twenty-five patients with histologically confirmed malignancies were enrolled and assessable. Vincristine doses were increased from 0.5 mg/m2 to 1.0, 1.5, 2.0, 2.4, and 2.8 mg/m2 with cohorts of three or more patients per dose level. A total of 64 courses of ONCO-TCS were administered intravenously once every 3 weeks. The pharmacokinetics of total vincristine content in plasma were determined using a high-performance liquid chromatography method. RESULTS: Patients were treated with vincristine doses up to 2.8 mg/m2; however, 2.4 mg/m2 was defined as the MTD and 2.0 mg/m2 as the phase II recommended dose. Pain and obstipation were the dose-limiting toxicites. Other toxicities were fever, rigors, fatigue, myalgias, and peripheral neuropathy. Hematologic toxicity was mild. All patients who were treated with doses above 1.5 mg/m2 received in excess of 2.0 mg of vincristine, with doses as high as 6.2 mg. One partial response was seen in a patient with pancreatic cancer. Tumor response not meeting partial response criteria was seen in two other patients. Pharmacokinetic studies revealed significantly elevated concentrations of total vincristine, but parameters varied and were not directly correlated with toxicity or response. CONCLUSION: The ability to administer elevated doses of vincristine, as well as indications of efficacy, suggests that ONCO-TCS warrants further clinical investigation in a phase II setting.  (+info)

Early harvest and late transplantation as an effective therapeutic strategy in multiple myeloma. (7/3052)

Transplantation after high-dose chemotherapy prolongs survival in patients with multiple myeloma compared with standard therapy. It is unclear whether the optimal timing of transplantation is immediately after induction chemotherapy or whether stem cells may be cryopreserved for transplantation at subsequent progression or relapse. In this study, stem cells were collected within 6 months of diagnosis, followed by transplantation only at progression of myeloma. One hundred and eighteen patients with multiple myeloma had stem cells collected and cryopreserved. Eleven had transplants early in the disease after they demonstrated failure to respond to primary therapy. The remaining 107 were eligible for transplants when there was evidence of progressive disease. Of the 118 patients, 67 had transplants, nine died of progressive disease before transplantation, and 42 remain alive in plateau phase. The median survival of the group is 58.5 months; 67 are alive. Serum beta2-microglobulin, bone marrow labeling index (S phase), and hemoglobin level predicted overall survival (P < 0.006, P < 0.001, and P < 0.01, respectively). We conclude that early cryopreservation of blood stem cells followed by transplantation at progression is a feasible approach to therapy in patients with myeloma. The underlying biology of the disease has a greater impact on survival than the timing of transplantation. A prospective randomized trial is required to answer definitively the question of the optimal timing of blood cell transplantation.  (+info)

Progressive multifocal leukoencephalopathy after autologous bone marrow transplantation and alpha-interferon immunotherapy. (8/3052)

A patient with a stage IV mantle cell lymphoma (according to the REAL classification) was treated with high-dose chemotherapy and autologous bone marrow transplantation. One year later while on alpha-interferon immunotherapy she suffered from progressive loss of short-term memory and reported difficulties in recognizing objects. Magnetic resonance imaging (MRI) showed a vast ring-enhancing lesion of the left postcentral parietal area. Serial stereotactic biopsies disclosed progressive multifocal leukoencephalopathy without JC-virus in the cerebrospinal fluid. Therapy with subcutaneous interleukin-2 (IL-2) every other day and intrathecal cytarabine once a week was started. After 4 weeks the patient refused further treatment. Nevertheless her condition improved over the next 8 months and MRI scans showed a marked improvement in the lesions.  (+info)

Name of the medicinal product Vincristine Sulfate 1mg USP solution for injection Vincristine Sulfate 2mg USP solution for injection Qualitative and quantitative composition a) Each sterile lyophilized vial contains Vincristine sulphate USP 1mg Mannitol ...
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The inhibitory effect of Oncovin (vincristine sulfate) on cell division was studied in human cell line NHIK 3025. Oncovin arrested the cells in metaphase at concentrations as low as 10(-3) mug/ml. At 8 X 10(-3) mug/ml and higher concentrations, the arrest was complete after 6 hr of treatment. The arrest was irreversible after exposure for 6 hr to 16 X 10(-3) mug Oncovin per ml. The X-ray radiosensitivity of aerobic cells of the same line pretreated with 16 X 10(-3) mug Oncovin per ml for 6 hr (Oncovin removed before irradiation) was found to be about equal to that of untreated cells. Even when present during irradiation, Oncovin did not exert any modifying effect on the radiosensitivity of either aerobic or extremely hypoxic cells.
RATIONALE: Everolimus may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Monoclonal antibodies, such as rituximab, can block cancer cells in different ways. Some block the ability of cancer cells to grow and spread. Others find cancer cells and help kill them or carry cancer-killing substances to them. Drugs used in chemotherapy, such as cyclophosphamide, doxorubicin hydrochloride, vincristine sulfate, and prednisone, work in different ways to stop the growth of cancer cells, either by killing the cells or stopping them from dividing. Giving everolimus together with rituximab, cyclophosphamide, doxorubicin hydrochloride, vincristine sulfate, and prednisone may kill more cancer cells.. PURPOSE: This phase I trial is studying the side effects and the best dose of everolimus when given together with rituximab and combination chemotherapy in treating patients with newly diagnosed untreated diffuse large B-cell lymphoma. ...
Vincristine sulfate liposome injection (VSLI; Marqibo) was developed to optimize vincristine pharmacokinetics, dose-intensification, and target-tissue delivery.
Learn more about Marqibo® (vinCRIStine sulfate LIPOSOME injection) at MARQIBO.com. Marqibo® is for the treatment of adult patients with Philadelphia chromosome-negative (Ph‒) acute lymphoblastic leukemia (ALL) in second or greater relapse or whose disease has progressed following 2 or more anti-leukemia therapies. This indication is based on overall response rate. Clinical benefit such as improvement in overall survival has not been verified.
Stage V FH, FA, or DA Wilms tumor: After bilateral conventional surgery (biopsy), patients with FH receive chemotherapy as in stratum 1 (dactinomycin IV weeks 0, 3, 6, 9, 12, 15, and 18 and vincristine sulfate IV weeks 1-10, 12, 15, and 18) or 4 (dactinomycin IV weeks 0, 6, 12, 18, and 24; doxorubicin hydrochloride IV weeks 3, 9, 15, and 21; and vincristine sulfate VCR IV weeks 1-10, 12, 15, 18, 21, and 24). Patients with FA or DA receive chemotherapy as in stratum 7 (vincristine sulfate VCR IV weeks 1, 2, 4-8, 10-13, 18, and 24; cyclophosphamide sulfate (CTX) IV over 1 hour on days 1-3 of weeks 6, 12, 18, and 24 and on days 1-5 of weeks 3, 9, 15, and 21; doxorubicin hydrochloride IV (beginning after CTX infusion) weeks 0, 6, 12, 18, and 24; and etoposide (VP-16) IV over 1 hour (beginning after CTX infusion) on days 1-5 of weeks 3, 9, 15, and 21. Filgrastim (G-CSF) is administered subcutaneously (SC) beginning 24 hours after completion of chemotherapy ...
RATIONALE: Everolimus may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Monoclonal antibodies, such as rituximab, can block cancer cells in different ways. Some block the ability of cancer cells to grow and spread. Others find cancer cells and help kill them or carry cancer-killing substances to them. Drugs used in chemotherapy, such as cyclophosphamide, doxorubicin hydrochloride, vincristine sulfate, and prednisone, work in different ways to stop the growth of cancer cells, either by killing the cells or stopping them from dividing. Giving everolimus together with rituximab, cyclophosphamide, doxorubicin hydrochloride, vincristine sulfate, and prednisone may kill more cancer cells.. PURPOSE: This phase I trial is studying the side effects and the best dose of everolimus when given together with rituximab and combination chemotherapy in treating patients with newly diagnosed untreated diffuse large B-cell lymphoma.. ...
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Treatment Strategies in Elderly Patients. In terms of induction strategies for treatment-naïve elderly patients, multiple regimens have been investigated in clinical trials. The University of Texas MD Anderson Cancer Center experience employing R-hyper-CVAD (rituximab, hyperfractionated cyclophosphamide, vincristine, doxorubicin, dexamethasone) alternating with high-dose methotrexate/cytarabine (R-MTX/AraC) showed a median failure-free survival (FFS) of 3 years in patients aged , 65 years versus 5.5 years in patients aged ≤ 65 years, revealing the inferior results achieved in the older patients. The University of Pennsylvania group reported the outcomes for 38 patients with MCL aged ≥ 60 years who received R-CHOP (rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone) or R-Hyper-CVAD with or without autologous stem cell transplantation (ASCT). This study demonstrated R-CHOP alone to be a less-effective treatment for older patients. The median progression-free survival ...
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Hyperfractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone (hyper-CVAD) plus ponatinib appears to be superior to hyper-CVAD plus dasatinib for the frontline treatment of patients with Philadelphia chromosome-positive ALL.
The goal of this clinical research study is to learn if intensive chemotherapy (hyper-CVAD therapy) given in combination with liposomal vincristine (Marqibo),
CASI Pharmaceuticals, Inc. is a biopharmaceutical company. The Company is focused on the acquisition, development and commercialization of therapeutics for cancer and other medical needs. It operates through the development of targeted therapeutics for the treatment of cancer segment. Its product pipeline includes internal development of its lead drug candidate, ENMD-2076; MARQIBO, ZEVALIN and EVOMELA, and early-stage candidates in preclinical development. Its ENMD-2076 is an orally active, Aurora A/angiogenic kinase inhibitor with a kinase selectivity profile and multiple mechanisms of action. Its Marqibo is a sphingomyelin/cholesterol liposome-encapsulated, formulation of vincristine sulfate. Its ZEVALIN (ibritumomab tiuxetan) injection for intravenous use is a CD20-directed radiotherapeutic antibody. Its EVOMELA is an intravenous formulation of melphalan being investigated by Spectrum in the multiple myeloma transplant setting. Its pipeline also includes 2ME2 (2-methoxyestradial).
Marqibo (vincristine sulfate liposome injection) has been approved by the U.S. Food and Drug Administration to treat adults with a rare form of blood and bone m
Recently, wearable devices have grown to be a prominent healthcare application domain simply by incorporating an increasing number of sensors and adopting clever machine learning technology. method runs on the mix of LSTM (Lengthy short-term storage) with a deep condition space model and probabilistic inference. Even more precisely, we utilize the expressive power of LSTM when managing high-dimensional period series data, and condition space model and probabilistic inference to extract low-dimensional latent representations useful for training. Experimental results present that our technique can yield promising outcomes for characterizing high-dimensional period series patterns and for offering useful information whenever using wearable IMU (Inertial measurement device) sensors for ping pong training. denotes the path, and denotes the amount of the network Vincristine sulfate distributor where in fact the cell is described. The operator ? denotes the element-wise multiplication procedure, while ...
The 10-year follow-up results from the LNH-98.5 trial, the first randomized study comparing the standard CHOP regimen to R-CHOP, confirm the benefits of adding rituximab to CHOP for the treatment of patients with DLBCL. The addition of rituximab improved PFS and OS rates in this patient population, with an overall increase of 16% versus CHOP alone. This difference was even more pronounced in patients exhibiting CR at the end of treatment (22%).. The patient cohort chosen for this trial was elderly DLBCL patients (60-80 years of age), a particularly challenging group to manage and treat. With the improvements in PFS and OS rates from the addition of rituximab to standard treatment regimens, a significant proportion of elderly patients experience long-term survival. At 10 years, more than 40% of the patients in our study were alive and in first CR. This emphasizes that the goal of treatment in elderly patients, as in younger patients, should be the cure of the lymphoma.. No plateau was reached for ...
BioAssay record AID 360916 submitted by ChEMBL: Cytotoxicity against vincristine-resistant mouse P388 cells in presence of 0.004 ug/mL vincristine.
Ive mentioned Hogan here and elsewhere a time or two. Hogan is an 8 year old Australian Shepherd who was in remission from Lymphoma for 4 years. [Since 2005.] This year has been a struggle keeping him in remission, the cancer popped up again June-ish and hes been treated with CCNU [http://www.chemocare.com/bio/ccnu.asp] He went back into remission until last Sunday. He got some diarrhea and his mom was giving him a neck massage and could feel his lymph nodes swollen in that area. It was confirmed at the emergency vet that he was out of remission. This all of course happened right before they were going out of town. I was scheduled to dog-sit for them way prior to this, and so they decided to continue with their trip plans. Hogan had a dose of vincristine on Tuesday. His parents left Wednesday. Hes been staying with me all week, coming in every day to work with me to have his lymph nodes checked. The swelling didnt go down like the doctor would have liked so he was put back on Prednisone. ...
December 17th, 2013, we knew very little about Childhood Cancer, the next day….we were forced to learn. September is Childhood Cancer Awareness month. Tomorrow, we will be at Nanaimo hospital. Olivia will be accessed. A nurse wearing a gown, gloves and a shield across her face will come into the room and hang a 2 ml bag of vincristine on an IV pole and she will push the button to start the drip. 4 weeks later we will be at BCCH. Olivia will be sedated and chemotherapy will be put into her spine. ...
Find information on Vincristine (Vincasar PFS) in Daviss Drug Guide including dosage, side effects, interactions, nursing implications, mechanism of action, half life, administration, and more. Davis Drug Guide PDF.
Find information on Vincristine (Vincasar PFS) in Daviss Drug Guide including dosage, side effects, interactions, nursing implications, mechanism of action, half life, administration, and more. Davis Drug Guide PDF.
As reported in The Lancet Oncology, Tilly et al found that the combination of polatuzumab vedotin, an antibody-drug conjugate targeting the CD79b component of the B-cell receptor, with immunochemotherapy showed high response rates in the phase II portion of a phase I/II study in previously untreated diffuse large B-cell lymphoma.. The phase II expansion of the study (conducted at 11 sites in the United States and France) included 66 patients with newly diagnosed disease. Patients received the polatuzumab vedotin recommended phase II dose of 1.8 mg/kg on day 2 of cycles 1 and 2 and on day 1 of subsequent 21-day cycles in combination with R-CHP (rituximab plus cyclophosphamide, doxorubicin, and prednisone; n = 45) or obinutuzumab plus CHP (G-CHP; n = 21) for a total of 6 or 8 cycles according to investigator preference.. Adverse Events. Among the patients receiving the phase II dose of polatuzumab vedotin, the most common adverse events of grade ≥ 3 were neutropenia (30%), febrile neutropenia ...
This study is currently recruiting participants. Verified May 2012 by UNC Lineberger Comprehensive Cancer Center First Received on November 2, 2010. &n…
Twelve patients with primary non-Hodgkins lymphomas of the CNS are described. Out of 5 CSF cytologies performed, 4 were positive. Radiotherapy was given to the tumour area in 3 patients, or to the whole brain in 5 patients. Four cases received radiotherapy to the spinal cord as well. Patients receiving ... read more whole CNS irradiation, including the spinal cord, seem to have a longer survival than patients with brain irradiation only. Out of the 5 patients with total brain irradiation, 2 showed a relapse in the spinal cord. It is suggested that therapy should be given not only to the tumour bearing areas, but should comprise the entire CNS. show less ...
Hana Biosciences, a biopharmaceutical company focused on advancing cancer care, recently announced that the US Food and Drug Administration (FDA) has granted orphan drug designation for vincristine sulfate liposomes injection (Marqibo) in the treatment of adult patients with acute lymphoblastic leukemia (ALL). 1
SILVER SPRING, Md. - The Food and Drug Administration has approved a new drug for treating a rare type of leukemia, the agency said Thursday.. The FDA approved South San Francisco, Calif.-based Talon Therapeutics Marqibo (vincristine sulfate liposome), an injectable drug for Philadelphia chromosome-negative acute lymphoblasic leukemia, or Ph-negative ALL. The drug, which consists of the widely used anti-cancer drug vincristine encased within a liposome - a drug delivery system made of a material similar to cell membranes - is approved for patients whose leukemia has returned twice or more or has progressed after two or more regimens of therapy.. According to the National Cancer Institute, part of the National Institutes of Health, more than 6,000 people will be diagnosed with ALL this year, and 1,440 will die from it. The disease is a rapidly progressing form of blood and bone marrow cancer more common in children than adults.. ...
This study aimed to systematically review and meta-analyze the value of pretransplant FDG-PET in predicting outcome after autologous stem cell transplantation (ASCT) in aggressive non-Hodgkin lymphoma. Medline was systematically searched, included studies were methodologically assessed and meta-analyzed, when possible. Overall methodological quality of included studies (n=11) was poor, with moderate ... read more risk of bias in the domains of study participation (n=7) and prognostic factor measurement (n=7), and high risk of bias in the domains of outcome measurement (n=10), and study confounding (n=11). In all aggressive non-Hodgkin lymphomas, pooled sensitivity and specificity were 54.0% and 73.1% in predicting treatment failure, and 54.5% and 68.7% in predicting death. Because of interstudy heterogeneity, additional subgroup analyses were performed. In newly diagnosed aggressive non-Hodgkin lymphoma, pooled sensitivity and specificity were 20.0% and 70.0% in predicting treatment failure, and ...
1 Hermans J, Drol AD, van Groningen K, et al. International Prognostic Index for aggressive non-Hodgkin lymphoma is valid for all malignancy grades. Blood. 1995l86:1460-1463.. 2 Alici S, Bavbek SE, Kaytan E, et al. Prognostic significance of the immunophenotype versus the International Prognostic Index in aggressive non-Hodgkin lymphoma. Clinical Lymphoma. 2003;4:52-55.. 3 De Santis V, Martelli M, Anticoli AP, et al. Localized stage I-IE aggressive non-Hodgkin lymphoma (NHL): results of prospective study with multimodality therapeutic approach. Anticancer Research. 2001;21:4169-4172.. 4 Bernard M, Cartron G, Rachieru P, et al. Long-term outcome of localized high-grade non-Hodgkin lymphoma treated with high dose CHOP regimen and involved field radiotherapy: results of a GOELAMS study. Haematologica. 2005:90:802-809.. 5 Roche. Study of MabThera in aggressive non-Hodgkin lymphoma in patients less than 60 years old halted two years early due to ...
TY - JOUR. T1 - Rituximab plus CHOP as an initial chemotherapy for patients with disseminated MALT lymphoma [4]. AU - Ennishi, Daisuke. AU - Yokoyama, Masahiro. AU - Mishima, Yuko. AU - Watanabe, Chie. AU - Terui, Yasuhito. AU - Takahashi, Shunji. AU - Takeuchi, Kengo. AU - Ikeda, Kazuma. AU - Tanimoto, Mitsune. AU - Hatake, Kiyohiko. PY - 2007/11. Y1 - 2007/11. UR - http://www.scopus.com/inward/record.url?scp=36048934446&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=36048934446&partnerID=8YFLogxK. U2 - 10.1080/10428190701636476. DO - 10.1080/10428190701636476. M3 - Article. C2 - 17990181. AN - SCOPUS:36048934446. VL - 48. SP - 2241. EP - 2243. JO - Leukemia and Lymphoma. JF - Leukemia and Lymphoma. SN - 1042-8194. IS - 11. ER - ...
PRIMARY OBJECTIVES: I. To determine the event-free survival (EFS) and overall survival (OS) of children with completely resected ependymoma treated with maintenance chemotherapy comprising vincristine sulfate, cisplatin, etoposide, and cyclophosphamide (VCEC) versus observation following post-operative conformal radiotherapy (cRT). SECONDARY OBJECTIVES: I. To estimate the EFS and OS of children with incompletely resected ependymoma who are unable to achieve a complete response (CR) by post-operative induction chemotherapy or by second surgery who are non-randomly assigned to cRT followed by VCEC. II. To further evaluate the EFS and OS of children with supratentorial classic ependymoma who achieve a complete resection at first or second resection or children who achieve a CR to short-course induction chemotherapy following first surgery. III. To determine the neurologic, neuropsychological, and endocrine long-term sequelae of surgery, cRT, and VCEC as compared to those patients treated on ...
The U.S. Food and Drug Administration today approved Marqibo (vincristine sulfate liposome injection) to treat adults with a rare type of leukemia called Philadelphia chromosome negative (Ph-) acute lymphoblastic leukemia (ALL).. ALL is a rapidly progressing form of blood and bone marrow cancer that is more commonly diagnosed in children than adults. According to the National Cancer Institute, an estimated 6,050 men and women will be diagnosed with ALL and 1,440 will die from the disease this year.. Marqibo is approved for patients whose leukemia has returned (relapsed) two or more times, or whose leukemia has progressed following two or more regimens of anti-leukemia therapy. Marqibo contains vincristine, a commonly used anti-cancer drug, encased within a liposome, a drug delivery vehicle composed of material similar to that of cell membranes. It is an injection administered once a week by a health care professional.. Marqibos approval demonstrates the FDAs commitment to the development and ...
Regimens that include multiple drugs may be referred to by an abbreviation after the nonproprietary names of the drugs have been provided at first mention (see also , Drug Abbreviations, and , Abbreviations, Clinical, Technical and Other Common Terms). Drug regimens used in oncology frequently are referred to by abbreviations of combinations of antineoplastic agents, but often the abbreviations are not derived from the INNs. For example, the letter O in MOPP is derived from Oncovin, the proprietary name for vincristine sulfate, and the A in ABVD is derived from Adriamycin, the proprietary name for doxorubicin hydrochloride. When the abbreviation
Regimens that include multiple drugs may be referred to by an abbreviation after the nonproprietary names of the drugs have been provided at first mention (see also , Drug Abbreviations, and , Abbreviations, Clinical, Technical and Other Common Terms). Drug regimens used in oncology frequently are referred to by abbreviations of combinations of antineoplastic agents, but often the abbreviations are not derived from the INNs. For example, the letter O in MOPP is derived from Oncovin, the proprietary name for vincristine sulfate, and the A in ABVD is derived from Adriamycin, the proprietary name for doxorubicin hydrochloride. When the abbreviation
On Tuesday the 2nd Kyler had a Bone Marrow Biopsy, which confirmed his Leukemia diagnosis and on Wednesday the 3rd he had his MediPort put in and his first Lumbar Puncture with Cytarabine chemotherapy. Thursday the 4th he started a twice daily oral steroid Dexamethasone and had his first weekly IV Vincristine treatment. On Sunday the 7th he had Pegaspargase chemotherapy. He stayed in the hospital receiving daily oral medicine and a few platelet transfusions until Thursday the 11th. On that Thursday Kyler received his second dose of Vincristine and his second Lumbar Puncture this time with Methotrexate chemotherapy and he was released to go home that evening. He continued receiving his oral medicine twice a day and on each Monday he has been having check ups to make sure his levels are staying on par with where they should be. On Thursdays he has his weekly Vincristine treatments. ...
Hana Biosciences has initiated a multicenter phase II clinical trial of Marqibo (vincristine sulfate liposome injection) in patients with relapsed or refractory acute lymphoblastic leukemia (ALL). The study is designed to support a phase III pivotal clinical trial of Marqibo for ALL, the company said in a press release. The primary objective of the phase II open-label study is to assess the efficacy of weekly doses of Marqibo plus pulse dexamethasone as measured by complete response rate. Hana expects to enroll up to 44 patients. ...
Background Telomere shortening is certainly thought to be involved in the pathophysiology of myeloid malignancies, but telomere lengths (TL) during interphase and metaphase in hematopoietic malignancies have not been analyzed. fusion of chromosomes at the ends [3], which results in instability of the genome and contributes to carcinogenesis. Therefore, studies on telomeres and telomerase have been a major focus of cancer research, including studies on hematologic malignancies [4,5,6,7]. MDS represents a series of clonal hematopoietic stem cell diseases that show cytopenia due to ineffective Vincristine sulfate hematopoiesis and morphologic dysplasia of the hematopoietic cells, and is associated with an increased risk of progression to AML [8]. Abnormal proliferation of dysplastic hematopoietic cells and peripheral cytopenia in MDS reflects the paradoxical coexistence of active proliferation and apoptosis. Several markers and prognostic scoring systems have been developed to predict AML ...
Newly diagnosed mantle cell lymphoma, admitted now to start chemotherapy. She will start treatment with hyperfractionated cyclophosphamide, vincristine,
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Introduction Severe leukemias very rarely present with jaundice. patient was treated with a hyperfractionated cyclophosphamide/vincristine/doxorubicin/dexamethasone regimen. Conclusion Acute lymphoblastic leukemia ought to be among the differential diagnoses that needs to.... ...
BioAssay record AID 464197 submitted by ChEMBL: Cytotoxicity against vincristine-resistant human KB/VJ300 cells in presence of 0.121 uM vincristine.
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We describe the effect and side effects in two children with cancer treated with intravenous methadone due to vincristine-induced neuropathy.
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Evidence-based information on vincristine from hundreds of trustworthy sources for health and social care. Make better, quicker, evidence based decisions. Evidence search provides access to selected and authoritative evidence in health, social care and public health.
Evidence-based information on vincristine from hundreds of trustworthy sources for health and social care. Make better, quicker, evidence based decisions. Evidence search provides access to selected and authoritative evidence in health, social care and public health.
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Toxicity (vincristine)[3]. In the sympathetic nervous system (SNS), predominant dysautonomia is common along with fibromyalgia ...
"Vincristine (Oncovin)". Archived from the original on 2007-06-29. Retrieved 2007-08-05. Fighting Cancer with a Pinch of Parsley ... Vincristine-used to treat lymphoma, breast cancer, lung cancer, and acute lymphoblastic leukemia. Vindesine-used to treat ... vincristine, and vinorelbine.Colchicine and griseofulvin are mitotic inhibitors used in the treatment of gout and toenail ...
VINCRISTINE SULPHATE 527. VINBLASTINE SULPHATE 528. VINDESINE SULPHATE 529. VINORELBINE TATRATE 530. XIPAMIDE ...
The original vinca alkaloids are natural products that include vincristine and vinblastine.[44][45][46][47] Following the ... therapies with low risk of gonadotoxicity include plant derivatives such as vincristine and vinblastine, antibiotics such as ... "Modifications on the basic skeletons of vinblastine and vincristine". Molecules. 17: 5893-5914. PMID 22609781. doi:10.3390/ ...
"Vincristine - FDA prescribing information, side effects and uses". Drugs.com. Retrieved 2018-03-10. "Vincristine: Mechanism of ... Vincristine is a drug isolated from the Madagascar periwinkle, first discovered by the Eli Lilly company in 1958 in a search ... Vincristine functions by binding to and inhibiting microtubule production in the mitotic spindle necessary for the cellular ... The VAMP regimen developed by Freireich and Frei was a combination of vincristine, amethopterin, mercaptopurine, and prednisone ...
Accidental administration of any vinca alkaloids-especially vincristine but also vinblastine, vinorelbine, or others-via the ... Schulmeister L (September 2004). "Preventing vincristine sulfate medication errors". Oncology Nursing Forum. 31 (5): E90-8. doi ... Qweider M, Gilsbach JM, Rohde V (March 2007). "Inadvertent intrathecal vincristine administration: a neurosurgical emergency. ...
These compounds include vinblastine, vincristine, vindesine, and vinorelbine. Additional researched vinca alkaloids include ... vincristine". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 11966-11970. Bibcode: ... leurosine and the chemotherapy agents vinblastine and vincristine, all of which can be obtained from the plant. The newer semi- ... "Modifications on the basic skeletons of vinblastine and vincristine". Molecules. 17 (5): 5893-5914. doi:10.3390/ ...
Moncrief, J. W.; Lipscomb, W. N. (1965). "Structures of Leurocristine (Vincristine) and Vincaleukoblastine. X-ray Analysis of ... Vincristine), which is used in several cancer therapies. Guggenheim Fellow, 1954 Fellow of the American Academy of Arts and ...
... and vincristine,[4] all of which can be obtained from the plant.[5][6][7][8] The newer semi-synthetic chemotherapeutic agent ... These compounds include vinblastine, vincristine, vindesine, and vinorelbine. Additional researched vinca alkaloids include ... "Stereocontrolled total synthesis of (+)-vincristine". Proceedings of the National Academy of Sciences of the United States of ... "Modifications on the basic skeletons of vinblastine and vincristine". Molecules. 17: 5893-5914. doi:10.3390/molecules17055893 ...
Methotrexate and vincristine have also been used. Other medications include cytokine targeted therapy. On 20 November 2018, the ...
Anticancer drugs such as doxorubicin and vincristine can adversely affect male fertility by damaging the DNA of proliferative ... Experimental exposure of rat undifferentiated spermatogonia to doxorubicin and vincristine indicated that these cells are able ... Beaud H, van Pelt A, Delbes G (2017). "Doxorubicin and vincristine affect undifferentiated rat spermatogonia". Reproduction. ...
Vincristine, which requires central venous access for administration, is traditionally used as a chemotherapy agent, but has ... 2004). "Vincristine treatment for function- and life-threatening infantile hemangioma". Arch Pediatr. 11 (2): 99-107. doi: ... Other systemic therapies which may be effective for IH treatment include vincristine, interferon, and other agents with ... "Treatment of life-threatening infantile hemangiomas with vincristine". N Engl J Med. 333 (1): 69. doi:10.1056/ ...
Commonly used drugs include cisplatin, vincristine, and methotrexate.[clarification needed] Side effects include anemia ( ...
Most of the drugs used in dogs are used in cats, but the most common protocol uses cyclophosphamide, vincristine, and ... The most common protocol uses prednisone, vincristine, and cyclophosphamide. Doxorubicin is used in some cases. Chemotherapy in ... The most common treatment is a combination of cyclophosphamide, vincristine, prednisone, L-asparaginase, and doxorubicin. Other ...
monthly 5-day course of intravenous vincristine and oral corticosteroids. Due to presence of CNS involvement in 10-40% of adult ...
Vincristine (Oncovin) (1963). *Actinomycin D (Cosmegen) (1964). *Mithramycin (Mithracin) (1970). *Bleomycin (Blenoxane) (1973) ...
... leurosine and the chemotherapy agents vinblastine and vincristine, all of which can be obtained from the plant. The newer semi- ... "Modifications on the basic skeletons of vinblastine and vincristine". Molecules. 17 (5): 5893-5914. doi:10.3390/ ...
Keglevich P, Hazai L, Kalaus G, Szántay C (May 2012). "Modifications on the basic skeletons of vinblastine and vincristine". ... On the other hand, therapies with low risk of gonadotoxicity include plant derivatives such as vincristine and vinblastine, ... The original vinca alkaloids are natural products that include vincristine and vinblastine. Following the success of these ...
Bisindole alkaloids vinblastine and vincristine are produced in the reaction involving catharanthine (alkaloid of type Iboga) ... Besides, bisindole alkaloids vinblastine and vincristine show antineoplastic effect. Because of structural similarities with ... vincristine). Apart from bisindole alkaloids, dimeric alkaloids exist which are formed via dimerization of the indole monomer ... and bisindole alkaloids vinblastine and vincristine are antitumor agents. Animal studies have shown that ibogaine has a ...
The chemotherapy agent vincristine is extracted from a closely related species, Catharanthus roseus, and is used to treat some ... Vinblastine is a chemical analogue of vincristine and is also used to treat various forms of cancer. Dimeric alkaloids such as ... "Modifications on the basic skeletons of vinblastine and vincristine". Molecules. 17 (5): 5893-5914. doi:10.3390/ ... vincristine and vinblastine are produced by the coupling the smaller indole alkaloids vindoline and catharanthine. In addition ...
Parasramka S, Talari G, Rosenfeld M, Guo J, Villano JL (July 2017). "Procarbazine, lomustine and vincristine for recurrent high ... lomustine and vincristine). A mutational analysis of 23 initial low-grade gliomas and recurrent tumors from the same patients ...
... such as the vinca alkaloids vinblastine and vincristine, which are formed from the coupling of catharanthine and vindoline. The ... "Modifications on the basic skeletons of vinblastine and vincristine". Molecules. 17 (5): 5893-5914. doi:10.3390/ ...
Keglevich P, Hazai L, Kalaus G, Szántay C (May 2012). "Modifications on the basic skeletons of vinblastine and vincristine". ... the vinca alkaloids vincristine and vinblastine, the taxanes paclitaxel and docetaxel, the proteasome inhibitors such as ...
... leurosine and the chemotherapy agents vinblastine and vincristine, all of which can be obtained from the plant. The newer semi- ... "Modifications on the basic skeletons of vinblastine and vincristine". Molecules. 17 (5): 5893-5914. doi:10.3390/ ...
"Modifications on the basic skeletons of vinblastine and vincristine". Molecules. 17 (5): 5893-5914. doi:10.3390/ ...
... is a vinca alkaloid and a chemical analogue of vincristine. It binds tubulin, thereby inhibiting the assembly of ... Keglevich P, Hazai L, Kalaus G, Szántay C (May 2012). "Modifications on the basic skeletons of vinblastine and vincristine". ...
The vinca alkaloids, including vincristine, are also associated with reversible ototoxicity. Topical skin preparations such as ... "Modifications on the basic skeletons of vinblastine and vincristine". Molecules. 17 (5): 5893-914. doi:10.3390/ ...
The plant produces about 130 of these compounds, including vinblastine and vincristine, two drugs used to treat cancer. ... "Modifications on the basic skeletons of vinblastine and vincristine". Molecules. 17 (5): 5893-5914. doi:10.3390/ ...
Vinblastine and vincristine , chemotherapy medications used to treat several types of cancers, are found in the plant and are ... It is a source of the drugs vincristine and vinblastine, used to treat cancer. It was formerly included in the genus Vinca as ... Despite the medical importance and wide use, the desire alkaloids (vinblastine and vincristine) are naturally produced at very ... In the 1950s, vinca alkaloids, including vinblastine and vincristine, were isolated from Catharanthus roseus by when screening ...
Keglevich P, Hazai L, Kalaus G, Szántay C (May 2012). "Modifications on the basic skeletons of vinblastine and vincristine". ... Tubulins are targets for anticancer drugs like the vinca alkaloid drugs vinblastine and vincristine, and paclitaxel. The anti- ...
Production of vincristine required one ton of dried periwinkle leaves to produce one ounce of vincristine. Periwinkle was grown ... The vincristine molecule inhibits leukocyte production and maturation. A downside, however, to Vincristine is that it does not ... A nano-particle bound version of vincristine was under development as of 2014. "Vincristine". Dictionary.com. Random House, Inc ... The liposome encapsulation of vincristine enhances the efficacy of the vincristine drug while simultaneously decreasing the ...
Severe neurological disorders and refractory aspergillosis in an adolescent treated by vincristine and voriconazole. Journal of ...
... has part vincristine(2+) (CHEBI:143658) vincristine sulfate (CHEBI:79401) has role ... CHEBI:79401 - vincristine sulfate. Main. ChEBI Ontology. Automatic Xrefs. Reactions. Pathways. Models. ... An organic sulfate salt containing equimolar amounts of vincristine(2+) and sulfate. Used for the treatment of a variety of ...
Oncovin injection contains the active ingredient vincristine, which is a type of chemotherapy medicine called a vinka alkaloid ... Oncovin (vincristine). Oncovin injection contains the active ingredient vincristine, which is a type of chemotherapy medicine ... Vincristine infusion may be given by a slow injection into a vein, or via a drip into a vein (intravenous infusion). The ... If vincristine leaks into the tissues around the vein, it can cause damage to the tissue there. For this reason, it is ...
Vincristine Injection: learn about side effects, dosage, special precautions, and more on MedlinePlus ... Before receiving vincristine,. *tell your doctor and pharmacist if you are allergic to vincristine, any other medications, or ... Talk to your doctor about the risks of receiving vincristine injection.. Vincristine may cause other side effects. Call your ... If you become pregnant while receiving vincristine injection, call your doctor. Vincristine may harm the fetus. ...
Vincristine News and Research. RSS Vincristine is the active ingredient in a drug used to treat acute leukemia. It is used in ... Vincristine is also being studied in the treatment of other types of cancer. It blocks cell growth by stopping cell division. ... lomustine and vincristine (PCV), experienced a longer progression-free survival and overall survival than patients who received ...
Vincristine definition, an alkaloid, C46H56N4O10, derived from the periwinkle, Vinca rosea, used in the management of leukemias ... Words nearby vincristine. Vincents angina, Vincents disease, Vinci, vincible, vincit omnia veritas, vincristine, vincristine ... vincristine. 1960-65; ,New Latin Vin(ca) a periwinkle genus + Latin crist(a) crest + -ine2 ...
Vincristine Lipid Complex Injection: learn about side effects, dosage, special precautions, and more on MedlinePlus ... Before receiving vincristine lipid complex,. *tell your doctor and pharmacist if you are allergic to vincristine, any other ... Your doctor may not want you to receive vincristine lipid complex or may need to change your dose of vincristine lipid complex ... If you become pregnant while receiving vincristine lipid complex, call your doctor. Vincristine may harm the fetus. ...
A list of US medications equivalent to Vincristine Sulphate Pharmachemie is available on the Drugs.com website. ... Vincristine Sulphate Pharmachemie is a medicine available in a number of countries worldwide. ... Ingredient matches for Vincristine Sulphate Pharmachemie. Vincristine. Vincristine sulfate (a derivative of Vincristine) is ... Vincristine Sulphate Pharmachemie. Vincristine Sulphate Pharmachemie may be available in the countries listed below. ...
vincristine synonyms, vincristine pronunciation, vincristine translation, English dictionary definition of vincristine. n. An ... vincristine. Also found in: Thesaurus, Medical, Acronyms, Encyclopedia, Wikipedia.. Related to vincristine: cyclophosphamide, ... Vincristine - definition of vincristine by The Free Dictionary https://www.thefreedictionary.com/vincristine ... vincristine. (vɪnˈkrɪstiːn) n. (Pharmacology) a cytotoxic drug used in the treatment of leukaemia, derived as an alkaloid from ...
Cisplatin rated 8.0/10 vs Vincristine rated 9.0/10 in overall patient satisfaction. ... Compare Cisplatin vs Vincristine head-to-head for uses, ratings, cost, side effects, interactions and more. ...
The liposome encapsulation of vincristine enhances the efficacy of the vincristine drug while simultaneously decreasing the ... "Vincristine". International Drug Price Indicator Guide. Retrieved 28 November 2015.. *^ del Pino BM. Chemotherapy-induced ... The vincristine molecule inhibits leukocyte production and maturation.[17] A downside, however, to Vincristine is that it does ... alternate methods to produce synthetic vincristine are being used.[19] Vincristine is created through the semi-synthesis ...
After treatment with vincristine has ended, or sometimes even during treatment, normal hair growth should return. ... Along with their needed effects, medicines like vincristine can sometimes cause unwanted effects such as blood problems, ...
Find patient medical information for Vincristine Intravenous on WebMD including its uses, side effects and safety, interactions ... Before using vincristine, tell your doctor or pharmacist if you are allergic to it or to vincristine liposomal; or if you have ... Vincristine injection is different than vincristine liposomal injection. The two drugs have different dosage recommendations. ... Other medications can affect the removal of vincristine from your body, which may affect how vincristine works. Examples ...
... is used to treat leukemia, Hodgkins disease, non-Hodgkins lymphoma, rhabdomyosarcoma (soft tissue tumors), ... Vincristine is cancer medication that interferes with the growth of cancer cells and slows their spread in the body. ... How is vincristine given?. Vincristine is injected into a vein through an IV. A healthcare provider will give you this ... What is vincristine?. Vincristine is cancer medication that interferes with the growth of cancer cells and slows their spread ...
Vincristine belongs to the group of medicines known as antineoplastic agents. It is used to treat some kinds of cancer as well ... Infection-Vincristine can reduce immunity to infection * Liver disease-Effects may be increased because of slower removal of ... Vincristine may lower your bodys resistance and there is a chance you might get the infection the immunization is meant to ... If vincristine accidentally seeps out of the vein into which it is injected, it may damage some tissues and cause scarring. ...
Vincristine Solution for injection drug summary. Find medication information including related drug classes, side effects, ... VINCRISTINE (vin KRIS teen) is a chemotherapy drug. It slows the growth of cancer cells. This medicine is used to treat many ... an unusual or allergic reaction to vincristine, other chemotherapy agents, other medicines, foods, dyes, or preservatives. - ...
Vincristine is administered intravenously and is used to treat many different types of cancer. It is frequently used in ... Vincristine may also have the ability to inhibit the protein synthesis of DNA and RNA.1 ... Malignancies in which vincristine is used include acute leukemia, rhabdoyosarcoma, neuroblastoma, Hodgkins disease and other ... Vincristines (Oncovin®, Vincasar PFS®, Vincrex®) anti-cancer properties result from its ability to inhibit cell division ...
Vincristine Liposomal (Marqibo) chemotherapy side effects, how its given, how it works, precautions and self care tips for ... For more detail, see "How Vincristine Liposomal Works" section below. What Vincristine Liposomal Is Used For:. *Vincristine ... Vincristine liposomal and conventional vincristine are NOT interchangeable.. Note: If a drug has been approved for one use, ... How Vincristine Liposomal Is Given:. *Vincristine liposomal is given as an infusion into the vein (intravenous, IV) over 1 hour ...
Note: Marqibo (vincristine sulfate liposome injection) has different dosage recommendations than vincristine sulfate injection ... Marqibo (vincristine sulfate liposome injection) is sphingomyelin/cholesterol liposome-encapsulated formulation of vincristine ... Vincristine sulfate liposome injection (VSLI), sphingomyelin and cholesterol nanoparticle vincristine (VCR), facilitates VCR ... Furthermore, Marqibo (vincristine sulfate liposome injection) has different dosage recommendations than vincristine sulfate ...
Vincristine sulfate for your research needs. Find product specific information including CAS, MSDS, protocols and references. ... Vincristine sulfate meets USP testing specifications Synonym: 22-. Oxovincaleukoblastine sulfate salt, Leurocristine sulfate ...
Find the most comprehensive real-world treatment information on Vincristine liposomal at PatientsLikeMe. 0 patients with ... bipolar I disorder or psoriasis currently take Vincristine liposomal. ... Vincristine liposomal is the generic form of Marqibo. It is a chemotherapy medication used for the treatment of acute ...
Vincristine Sulfate Injection. Reason for the Shortage. * *Pfizer had vincristine on shortage due to manufacturing delays. ... Vincristine injection, Pfizer, 1 mg/mL, 1 mL vial, 1 count, NDC 61703-0309-06 ... Vincristine injection, Pfizer, 1 mg/mL, 2 mL vial, 1 count, NDC 61703-0309-16 ...
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Before you are given Vincristine Sulfate Injection. When you must not be given it. Do not use Vincristine Sulfate Injection if: ... While You Are Being Given Vincristine Sulfate Injection. Things you MUST do:. Vincristine Sulfate Injection can temporarily ... What Vincristine Sulfate Injection is used for. Vincristine sulfate belongs to a group of anticancer medicines called Vinca ... Vincristine Sulfate Injection contains Vincristine Sulfate, Mannitol and Water for Injections. It does not contain a ...
Vincristine(Oncovin) generic is a chemotherapy agent, prescribed for certain types of cancer such as leukemia, Hodgkin disease ... General Information on Vincristine. Generic Name : Vincristine Pronunciation : vin-KRIS-teen. Latest prescription information ... How should Vincristine be taken? It comes as a solution for injection to be administered by a healthcare provider into the vein ... What are the side effects of Vincristine? Most Common : Hair loss. Gastrointestinal : Constipation, abdominal cramps, weight ...
bryostatin 1, vincristine sulfate. Location. Ireland Cancer Center at University Hospitals Case Medical Center. Cleveland. Ohio ... PURPOSE: This phase I trial is studying the side effects and best dose of bryostatin-1 when given together with vincristine in ... More From BioPortfolio on "Bryostatin and Vincristine in B-Cell Malignancies". *Related Companies*Related Events*Related ... OBJECTIVES: I. Determine the maximum tolerated dose of bryostatin 1 when combined with vincristine in patients with B-cell ...
Vincristine is the active ingredient of vincristine sulfate. The brand name Oncovin has been taken off the market and is no ... vincristine sulfate listen (vin-KRIS-teen SUL-fayt) A drug used to treat acute leukemia. It is sometimes used with other drugs ... Vincristine sulfate blocks cell growth by stopping cell division. It is a type of vinca alkaloid and a type of antimitotic ...
... N Engl J Med. 2016 Apr 7;374(14):1344-55. doi: 10.1056/ ... Early results of this trial showed that treatment with procarbazine, lomustine (also called CCNU), and vincristine after ...
Patients being treated with vincristine who have questions on availability should have a member of their healthcare team ... About Vincristine:. Vincristine is an FDA-approved chemotherapy agent that is used to treat some types of lymphoma. Vincristine ... Vincristine is only administered to patients in an infusion center, clinic or hospital. Patients being treated with vincristine ... Lymphoma Research Foundation Update on Vincristine Supply. The Lymphoma Research Foundation is aware that the supply of the ...
  • The treatment started with rituximab (500 mg/day), cyclophosphamide (1125 mg/day), adriablastine (80 mg/day), vincristine (2 mg/day), and prednisolone (80 mg/day). (thefreedictionary.com)
  • Authors' objectives To compare the effectiveness of rituximab with cyclophosphamide, doxorubicin, vincristine and prednisone (R-CHOP). (evidence.nhs.uk)
  • RATIONALE: Drugs used in chemotherapy, such as vincristine, dactinomycin, and cyclophosphamide, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. (clinicaltrials.gov)
  • PURPOSE: This phase II trial is studying how well giving vincristine, dactinomycin, and cyclophosphamide together works in treating patients with embryonal rhabdomyosarcoma. (clinicaltrials.gov)
  • Determine the progression-free survival rate in patients with low-risk embryonal rhabdomyosarcoma treated with intensive chemotherapy comprising vincristine, dactinomycin, and cyclophosphamide followed by vincristine and dactinomycin. (clinicaltrials.gov)
  • OUTLINE: Patients receive vincristine IV, dactinomycin IV, and cyclophosphamide IV on day 1. (clinicaltrials.gov)
  • Here you can see the latest Cisplatin Cyclophosphamide Lomustine Vincristine Sulfate Radiation Therapy Brain articles that have been published worldwide. (bioportfolio.com)
  • We have published hundreds of Cisplatin Cyclophosphamide Lomustine Vincristine Sulfate Radiation Therapy Brain news stories on BioPortfolio along with dozens of Cisplatin Cyclophosphamide Lomustine Vincristine Sulfate Radiation Therapy Brain Clinical Trials and PubMed Articles about Cisplatin Cyclophosphamide Lomustine Vincristine Sulfate Radiation Therapy Brain for you to read. (bioportfolio.com)
  • In addition to the medical data, news and clinical trials, BioPortfolio also has a large collection of Cisplatin Cyclophosphamide Lomustine Vincristine Sulfate Radiation Therapy Brain Companies in our database. (bioportfolio.com)
  • You can also find out about relevant Cisplatin Cyclophosphamide Lomustine Vincristine Sulfate Radiation Therapy Brain Drugs and Medications on this site too. (bioportfolio.com)
  • Addition of Vincristine and Irinotecan to Vincristine, Dactinomycin, and Cyclophosphamide Does Not Improve Outcome for Intermediate-Risk Rhabdomyosarcoma: A Report From the Children's Oncology Group. (bioportfolio.com)
  • The primary aim of this study was to improve the outcome of patients with intermediate-risk RMS by substituting vincristine and irinotecan (VI) for half of vincristine, dactinomycin, and cyclophosphamide (VAC) courses. (bioportfolio.com)
  • Immunochemotherapy with cyclophosphamide, adriamycin, vincristine, prednisone and rituximab (R-CHOP) is the standard treatment in non-immunosuppressed patients with diffuse large B-cell lymphoma (DLBCL), but its adequacy has not been definitively established in patients with human immunodeficiency virus (HIV)-related lymphoma. (wiley.com)
  • I. To compare the complete response rate at 6 cycles after randomization as defined by centrally read positron emission tomography (PET)/computed tomography (CT) (integral biomarker) of 2 targeted therapeutic regimens (obinutuzumab + PI3K-delta inhibitor TGR-1202 [TGR-1202] or obinutuzumab + lenalidomide) with obinutuzumab + cyclophosphamide, doxorubicin hydrochloride, vincristine sulfate, and prednisone (CHOP) in patients with early relapsing or refractory follicular lymphoma. (centerwatch.com)
  • ARM III: Patients receive obinutuzumab IV on day 1, cyclophosphamide IV over 15 minutes on day 1, doxorubicin hydrochloride IV on day 1, vincristine sulfate IV on day 1, and prednisone PO on days 1-5. (centerwatch.com)
  • 2002. "Randomized phase III study of fludarabine phosphate versus cyclophosphamide, vincristine, and prednisone in patients with recurrent low-grade non-Hodgkin's lymphoma previously treated with an alkylating agent or alkylator-containing regimen. (eviq.org.au)
  • PURPOSE: To compare in a phase III study the safety and efficacy of fludarabine to that of cyclophosphamide, vincristine, and prednisone (CVP) in recurrent, low-grade, non-Hodgkin's lymphoma after previous response to systemic treatment. (eviq.org.au)
  • PATIENTS AND METHODS: Patients were randomized to fludarabine (25 mg/m(2) intravenously on days 1 to 5, every 28 days) or CVP (cyclophosphamide 750 mg/m(2) and vincristine 1.2 mg/m(2) both intravenously on day 1 and prednisone 40 mg/m(2) orally on days 1 to 5, every 21 days). (eviq.org.au)
  • The combination of cyclophosphamide, vincristine, and prednisone (CVP) is one of several standard treatment options for advanced follicular lymphoma. (eviq.org.au)
  • PATIENTS AND METHODS: In total, 588 patients with stage 2 to 4 FL received first-line rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP). (rti.org)
  • A 52-year-old female painter suffering from high-grade non-Hodgkin's lymphoma (stage IVB) was treated with a total of 4 mg of vincristine during two courses of CHOP chemotherapy (cyclophosphamide, vincristine, adriamycin, prednisone). (prohealth.com)
  • Vincristine, also known as leurocristine and marketed under the brand name Oncovin among others, is a chemotherapy medication used to treat a number of types of cancer. (wikipedia.org)
  • Oncovin injection contains the active ingredient vincristine, which is a type of chemotherapy medicine called a vinka alkaloid. (netdoctor.co.uk)
  • The Lymphoma Research Foundation is aware that the supply of the vital chemotherapy medicine vincristine [Oncovin] may be limited in certain areas of the country. (lymphoma.org)
  • The Joint Commission on Accreditation of Healthcare Organizations (JCAHO) issued a warning about the use of Vincristine (Generic: Oncovin), a potent cancer drug. (yourlawyer.com)
  • Vincristine is sold in the United States under the names Oncovin and Vincasar. (yourlawyer.com)
  • Ang Vincristine (tatak na pangalan na Oncovin) na pormal na kilala bilang f leurocristine na minsang pinaikli na "VCR" ay isang vinca alkaloid mula sa Catharanthus roseus (Madagascar periwinkle) na dating Vinca rosea at kaya ito ang pangalan nito. (wikipedia.org)
  • Why would vincristine (oncovin) be fatal? (healthtap.com)
  • Vincristine infusion may be given by a slow injection into a vein, or via a drip into a vein (intravenous infusion). (netdoctor.co.uk)
  • It is important for you to tell your doctor how you are feeling during your treatment with vincristine injection. (medlineplus.gov)
  • Your doctor may tell you to take a stool softener or laxative to help prevent constipation during your treatment with vincristine injection. (medlineplus.gov)
  • tell your doctor and pharmacist if you are allergic to vincristine, any other medications, or any of the ingredients in vincristine injection. (medlineplus.gov)
  • Your doctor may not want you to receive vincristine injection. (medlineplus.gov)
  • Your doctor may not want you to receive vincristine lipid complex or may need to change your dose of vincristine lipid complex injection. (medlineplus.gov)
  • Vincristine injection is different than vincristine liposomal injection. (webmd.com)
  • Call your doctor for instructions if you miss an appointment for your vincristine injection. (adventisthealthcare.com)
  • Aetna considers continuation of vincristine sulfate liposome injection (Marqibo) medically necessary for members with ALL meeting initial selection criteria, and when there is no evidence of unacceptable toxicity or disease progression while on the current regimen. (aetna.com)
  • Vincristine sulfate liposome injection is available as the Marqibo Kit. (aetna.com)
  • Note: Marqibo (vincristine sulfate liposome injection) has different dosage recommendations than vincristine sulfate injection. (aetna.com)
  • The recommended dose of Marqibo (vincristine sulfate liposome injection) is 2.25 mg/m 2 intravenously over 1 hour once every 7 days. (aetna.com)
  • Marqibo (vincristine sulfate liposome injection) is sphingomyelin/cholesterol liposome-encapsulated formulation of vincristine sulfate for intravenous administration. (aetna.com)
  • Vincristine sulfate liposome injection (VSLI), sphingomyelin and cholesterol nanoparticle vincristine (VCR), facilitates VCR dose-intensification and densification plus enhances target tissue delivery. (aetna.com)
  • In 2012, Marqibo (vincristine sulfate liposome injection) was approved by the U.S. Food and Drug Administration for the treatment adult patients with Philadelphia chromosome‐negative (Ph‐) acute lymphoblastic leukemia (ALL) in second or greater relapse or whose disease has progressed following two or more anti‐leukemia therapies. (aetna.com)
  • Marqibo (vincristine sulfate liposome injection) is contraindicated in patients with demyelating conditions, including Charcot-Marie-Tooth syndrome. (aetna.com)
  • This leaflet answers some common questions about Vincristine Sulfate Injection. (mydr.com.au)
  • Your doctor has weighed the risks of you taking Vincristine Sulfate Injection against the benefits this medicine is expected to have for you. (mydr.com.au)
  • Your doctor will advise you about continuing to take other medicines while you are receiving Vincristine Sulfate Injection. (mydr.com.au)
  • Vincristine Sulfate Injection must only be given by a doctor or nurse. (mydr.com.au)
  • This rarely happens as Vincristine Sulfate Injection is administered under the care of a highly trained doctor. (mydr.com.au)
  • Vincristine Sulfate Injection can temporarily lower the number of white blood cells in your blood, increasing the chance of you getting an infection. (mydr.com.au)
  • Combination of Blinatumomab and Vincristine Sulfate Liposome Injection for Treatment of Relapsed Philadelphia Chromosome Positive B-cell Acute Lymphoblastic Leukemia. (bioportfolio.com)
  • Vincristine is typically utilized as a weekly injection. (marvistavet.com)
  • Delivering vincristine via mini-IV drip bags instead of pushing it with a syringe might avoid injection into spinal fluid, which is uniformly fatal. (cancernetwork.com)
  • Simply diluting and delivering vinca alkaloids like vincristine via mini-IV drip bags instead of pushing these chemotherapy agents with a syringe might avoid accidental injection into spinal fluid, researchers reported in a poster session at the Oncology Nursing Society (ONS) 42nd Annual Congress, held May 4-7 in Denver. (cancernetwork.com)
  • Hana Biosciences, a biopharmaceutical company focused on advancing cancer care, recently announced that the US Food and Drug Administration (FDA) has granted orphan drug designation for vincristine sulfate liposomes injection (Marqibo) in the treatment of adult patients with acute lymphoblastic leukemia (ALL). (cancernetwork.com)
  • Talon Therapeutics, Inc, announced the Oncologic Drugs Advisory Committee voted 7 yes, 4 no, and 2 abstain that evidence from clinical studies supports a favorable benefit-risk assessment for use of vincristine sulfate liposomes injection (Marqibo). (ascopost.com)
  • In August 2012, vinCRIStine sulfate LIPOSOME injection (Marqibo) was granted accelerated approval for the treatment of adult patients with Philadelphia chromosome-negative (Ph-) acute lymphoblastic leukemia (ALL) in second or greater relapse or whose disease has progressed following two or more antileukemia therapies. (ascopost.com)
  • The liposomal formulation of this drug has different dosage recommendations than vincristine sulfate injection. (ascopost.com)
  • Abstract 3356: Comparative plasma and cerebrospinal (CSF) pharmacokinetics (PK) of vincristine sulfate standard preparation (VCR) and vincristine sulfate liposomes injection (VSLI) in a non-human primate (NHP) model. (aacrjournals.org)
  • The IVADo regimen-a pilot study with ifosfamide, vincristine , actinomycin D, and doxorubicin in children with metastatic soft tissue sarcoma: a pilot study of behalf of the European pediatric Soft tissue sarcoma Study Group. (thefreedictionary.com)
  • The patient received vincristine as a part of the etoposide, doxorubicin, and prednisone (OEPA) regimen. (thefreedictionary.com)
  • However, doxorubicin did not enhance the autophagy induced by cotylenin A. A colony-forming assay indicated that the combined treatment with cotylenin A and vincristine more effectively suppressed the formation of large colonies, which have higher self-renewal activity than vincristine alone. (sigmaaldrich.com)
  • For many years, infusional vincristine, doxorubicin, dexamethasone (VAD) was used as pre-transplant induction therapy for patients who were candidates for AuSCT. (eviq.org.au)
  • How can vincristine and doxorubicin be fatal to a cell? (healthtap.com)
  • What is the action of vincristine and doxorubicin and why can they be fatal to a cell? (healthtap.com)
  • A chemotherapeutic protocol using carmustine-BCNU (50mg/m 2 at 6 weeks intervals) associated with vincristine (0,75mg/m 2 at 3 weeks intervals) and prednisone (40 mg/m 2 each other day) was evaluated in dogs with malignant lymphoma. (vin.com)
  • On study CCG-161 of the Childrens Cancer Study Group (CCSG), 631 children with acute lymphoblastic leukemia (ALL) at low risk for relapse were randomized to receive monthly pulses of vincristine-prednisone (VCR-PDN ) during maintenance therapy in addition to standard therapy with mercaptopurine (6MP) and methotrexate (MTX), and either cranial irradiation during consolidation or intrathecal (IT) MTX every 3 months during maintenance. (uni-bonn.de)
  • Vincristine comes as a solution (liquid) to be injected intravenously (into a vein) by a doctor or nurse in a medical facility. (medlineplus.gov)
  • Vincristine is administered intravenously and is used to treat many different types of cancer. (cancerquest.org)
  • Vincristine must absolutely be given intravenously. (marvistavet.com)
  • Vincristine is highly irritating to the soft tissues and if it is not given intravenously, where the bloodstream rapidly carries it away and dilutes it within the body's blood volume, it will cause what is called a "tissue slough. (marvistavet.com)
  • Venetoclax is taken orally (by mouth) and liposomal vincristine is given intravenously (by vein). (mskcc.org)
  • Patients then receive vincristine IV and dactinomycin IV on day 1. (clinicaltrials.gov)
  • If you miss an appointment to receive vincristine, contact your doctor as soon as possible to reschedule your appointment. (medbroadcast.com)
  • Patients also receive vincristine IV over 1 minute on days 1 and 8. (clinicaltrials.gov)
  • Cotylenin A and vincristine synergistically inhibited the growth and induced apoptosis in myeloma cells. (sigmaaldrich.com)
  • More importantly, a combination of AZM and a low dose of the common anti-cancer chemotherapeutic agent vincristine (VCR), produced a selectively synergistic effect on apoptosis of Hela and SGC-7901 cells, but not BHK-21 cells. (mdpi.com)
  • Zhao B, Li B, Liu Q, Gao F, Zhang Z, Bai H and Wang Y: Effects of matrine on the proliferation and apoptosis of vincristine‑resistant retinoblastoma cells. (spandidos-publications.com)
  • The drug also decreased the amount of alternatively spliced, antiapoptotic BCL2 family proteins, altogether poising cells for apoptosis upon exposure to vincristine. (sciencemag.org)
  • 2,3 Vincristine induces cell cycle-specific cytotoxicity by binding to tubulin during mitosis, resulting in microtubule depolymerization and metaphase arrest and thus apoptosis. (ascopost.com)
  • The liposome encapsulation of vincristine enhances the efficacy of the vincristine drug while simultaneously decreasing the neurotoxicity associated with it. (wikipedia.org)
  • The anticipated activity associated with vincristine has traditionally been limited by its short half-life, and its inability to be dose-escalated beyond 2 mg due to neurotoxicity. (cancernetwork.com)
  • Increased risk of vincristine neurotoxicity associated with low CYP3A5 expression genotype in children with acute lymphoblastic leukemia. (springer.com)
  • moreover, it reduced the systemic toxicity and peripheral neurotoxicity of vincristine. (rsc.org)
  • Dosing of conventional vincristine is limited by significant neurotoxicity due to binding to neuronal tubulin, with such toxicity occurring at doses higher than 1.4 mg/m 2 and leading to capping of the total dose of vincrsitine. (ascopost.com)
  • In some cases, health care professionals may use the trade name Marqibo® when referring to the generic drug name vincristine liposomal. (chemocare.com)
  • After preparation, each single-dose vial of Marqibo contains 5 mg/31 mL (0.16 mg/mL) vincristine sulfate for intravenous use only. (aetna.com)
  • Marqibo is also contraindicated in patients with hypersensitivity to vincristine sulfate or any of the other components of Marqibo, and it is contraindicated for intrathecal administration (Acrotech, 2020). (aetna.com)
  • Vincristine liposomal is the generic form of Marqibo. (patientslikeme.com)
  • Marqibo utilizes vincristine encapsulated in a rigid, lipid bilayer of sphingomyelin. (cancernetwork.com)
  • The sphingosome encapsulated technology employed by Marqibo results in a more rigid liposome that is designed to allow the active vincristine to leak out of the liposome slowly, maintaining drug levels for prolonged periods of time. (cancernetwork.com)
  • Liposome encapsulation of vincristine also enhanced the antitumor activity against murine P388 and L1210 lymphocytic leukemia models. (aacrjournals.org)
  • Liposomal encapsulation of vincristine prolongs circulation of active drug and passively targets it to tissues with fenestrated vasculature (eg, bone marrow, lymph nodes, spleen, liver, and solid tumors), resulting in increased penetration and accumulation in tumor tissue and potentially reducing levels in neural tissue compared with free vincristine. (ascopost.com)
  • Most people experience some side effects from vincristine treatment. (wikipedia.org)
  • Treatment with vincristine is given in several cycles of treatment. (netdoctor.co.uk)
  • Vincristine is also being studied in the treatment of other types of cancer. (news-medical.net)
  • Vincristine sulfate, as a single agent given IV once weekly, 4-8 doses is most common treatment protocol for TVT. (thefreedictionary.com)
  • After treatment with vincristine has ended, or sometimes even during treatment, normal hair growth should return. (mayoclinic.org)
  • Trouble breathing may rarely occur with vincristine treatment, especially when it is given with another chemotherapy drug, mitomycin -C. Patients with lung problems may be more sensitive to this side effect. (webmd.com)
  • Use effective birth control to avoid pregnancy during your treatment with vincristine. (adventisthealthcare.com)
  • Before you begin treatment with vincristine, you and your doctor should talk about the good this medicine will do as well as the risks of using it. (mayoclinic.org)
  • Before starting vincristine liposomal treatment, make sure you tell your doctor about any other medications you are taking (including prescription, over-the-counter, vitamins, herbal remedies, etc. (chemocare.com)
  • Do not have any vaccinations (immunisations) without your doctor's approval while you are being treated with vincristine, and for up to 12 months after you stop treatment with it. (mydr.com.au)
  • Early results of this trial showed that treatment with procarbazine, lomustine (also called CCNU), and vincristine after radiation therapy at the time of initial diagnosis resulted in longer progression-free survival, but not overall survival, than radiation therapy alone. (nih.gov)
  • Combined treatment with cotylenin A and vincristine induced autophagy (formation of LC3-II and degradation of p62 protein). (sigmaaldrich.com)
  • Expression of pluripotency-associated transcription factor Sox2 mRNA in RPMI-8226 myeloma cells was significantly suppressed by treatment with cotylenin A. Combined treatment with cotylenin A and vincristine significantly inhibited the growth of KMS-26 myeloma cells as xenografts. (sigmaaldrich.com)
  • The neurologic toxicities noted above are more likely to occur when vincristine is used in combination with L-Asparaginase , not an uncommon combination in the treatment of lymphoma. (marvistavet.com)
  • A new study has revealed that children with acute lymphoblastic leukemia (ALL) who had a certain gene variant experienced a higher incidence and severity of peripheral neuropathy after receiving treatment with the cancer drug vincristine. (medindia.net)
  • The study included participants in 1 of 2 prospective clinical trials for childhood ALL that included treatment with 36 to 39 doses of vincristine. (medindia.net)
  • hence, the present study aimed to evaluate the epididymal toxicity associated with vincristine treatment, which also contributes to the overall reproductive toxicity associated with vincristine. (ijpsonline.com)
  • Furthermore, treatment with the prepared liposomes coupled with UV light exposure produced greater antitumor effects in nude mice and reduced side effects, as compared with free vincristine sulfate. (dovepress.com)
  • Since Liposomal Vincristine may prevent the body from making and/or keeping new blood cells, prior to treatment patients will also have a Human Immunodeficiency Virus (AIDS virus) test, a blood test to detect the presence of antibodies to the AIDS virus. (knowcancer.com)
  • Ledipasvir should all not be added compensation to vincristine therapy as problematic a preventive or treatment, but should be reserved for transient therapy of adverse medication reactions. (dreamakergifts.com)
  • In this study, researchers are assessing the safety and effectiveness of adding the drug venetoclax to liposomal vincristine treatment in patients with T-cell ALL and B-cell ALL that has come back or continues to grow despite prior therapy. (mskcc.org)
  • Vincristine treatment of advanced cancer: a cooperative study of 392 cases. (springer.com)
  • Finally she consulted a neurologist and was admitted to hospital for further diagnostic studies and continuation of treatment for her lymphoma in March 1998 with a provisional diagnosis of severe vincristine-induced neuropathy. (prohealth.com)
  • Table 3 presents again the adverse events observed him during treatment agreement with dangerous substance tablets which were considered to be filling a consequence of the expected pharmacologic effects characteristic of vincristine. (dreamakergifts.com)
  • Vincristine is an anti-cancer drug and has been used for over 50 years in cancer treatment. (healthtap.com)
  • In conclusion, our results strongly support the clinical use of mebendazole as a replacement for vincristine for the treatment of brain tumors. (molmed.org)
  • In addition, PDMP treatment resulted in a decreased efflux of [ 14 C]Taxol and [ 3 H]vincristine from neuroblastoma cells, similar to treatment with PSC833 or MK571, suggesting an effect of PDMP on the transporter proteins P-glycoprotein and/or multidrug resistance protein. (aacrjournals.org)
  • Examples of mitotic inhibitors frequently used in the treatment of cancer include paclitaxel, docetaxel, vinblastine, vincristine, and vinorelbine.Colchicine and griseofulvin are mitotic inhibitors used in the treatment of gout and toenail fungus, respectively. (wikipedia.org)
  • Vincristine is used in combination with other chemotherapy drugs to treat certain types of leukemia (cancer of the white blood cells), including acute myeloid leukemia (AML, ANLL) and acute lymphoblastic leukemia (ALL), Hodgkin's lymphoma (Hodgkin's disease), and non-Hodgkin's lymphoma (types of cancer that begin in a type of white blood cells that normally fights infection). (medlineplus.gov)
  • Vincristine is used to treat leukemia, Hodgkin's disease, non-Hodgkin's lymphoma, rhabdomyosarcoma (soft tissue tumors), neuroblastoma (cancer that forms in nerve tissue), and Wilms' tumor. (adventisthealthcare.com)
  • PURPOSE: This phase I trial is studying the side effects and best dose of bryostatin-1 when given together with vincristine in treating patients with chronic lymphocytic leukemia, non-Hodgkin's lymphoma, or multiple myeloma. (bioportfolio.com)
  • Patients being treated with vincristine who have questions on availability should have a member of their healthcare team contact the LRF Helpline at [email protected] or 800-500-9976 for additional information. (lymphoma.org)
  • Vincristine is an FDA -approved chemotherapy agent that is used to treat some types of lymphoma. (lymphoma.org)
  • Vincristine is used alone or in combination with other antineoplastic medications to treat many different types of cancer , including leukemia (cancer of white blood cells), lymphoma (cancer of the lymph cells), breast cancer, lung cancer, malignant melanoma, cancer of the cervix, colorectal cancer, and Wilms' tumor. (medbroadcast.com)
  • Lymphoma , Mast Cell Tumors , and Transmissible Venereal Tumors often include vincristine in their protocols. (marvistavet.com)
  • Vincristine is supposed to be injected into a vein but is sometimes accidentally added to spinal catheters used for different drugs in leukemia and lymphoma patients. (yourlawyer.com)
  • Vincristine, an FDA-approved, standard chemotherapeutic used in most lymphoma and ALL regimens, is a cell-cycle-specific agent whose activity is dependent on the duration of drug exposure. (cancernetwork.com)
  • Does the omission of vincristine affect outcome and survival in patients with diffuse large B-cell lymphoma? (diva-portal.org)
  • found that YK-4-279 sensitized ES cells to the chemotherapeutic drug vincristine in ways that converged on mitotic catastrophe. (sciencemag.org)
  • The B-lineage pediatric ALL cell line CCRF-SB was gradually exposed to the chemotherapeutic vincristine until proliferation was observed at 6 nM, control cells were cultured in the absence of vincristine. (elsevier.es)
  • The 50% lethal dose of 1.9 mg/kg in CD-1 mice observed for free vincristine increased to 4.8 mg/kg upon administration of the drug in liposomal form. (aacrjournals.org)
  • Since free vincristine undergoes rapid cellular uptake and extensive tissue binding, it has a half-life of minutes and low levels of free drug are present in plasma. (ascopost.com)
  • Vincristine liposomal and conventional vincristine are NOT interchangeable. (chemocare.com)
  • In phase I and II clinical trials, liposomal vincristine has been shown to have a significantly longer half-life, and patients have been able to tolerate doses that are approximately 100% greater than conventional vincristine. (cancernetwork.com)
  • Liposomal vincristine has shown greater antitumor activity in vitro and in animal models compared with conventional vincristine at equivalent (mg/kg) doses, and was more likely to be curative in mouse models using leukemia cell lines. (ascopost.com)
  • Unlike the tissue sloughs of adriamycin , a vincristine slough will eventually heal but while it is present, it will require bandaging and be a source of discomfort. (marvistavet.com)
  • Vincristine is also used in combination with other chemotherapy drugs to treat Wilms tumor (a type of kidney cancer that occurs in children), neuroblastoma (a cancer that begins in nerve cells and occurs mainly in children), and rhabdomyosarcoma (cancer that forms in muscles in children). (medlineplus.gov)
  • What other drugs will affect vincristine? (adventisthealthcare.com)
  • The recommended dose and dosing schedule of vincristine varies according to the specific type of cancer being treated, the response to therapy, and the other drugs or treatments being used. (medbroadcast.com)
  • Vincristine is a member of the "vinca alkaloid" class of chemotherapy drugs. (marvistavet.com)
  • The alert also says that Vincristine also should be given to patients at different times and in different rooms than drugs administered through the spine. (yourlawyer.com)
  • The goal of this clinical research study is to learn if the combination of clofarabine, idarubicin, cytarabine, vincristine, and dexamethasone, with or without rituximab, can help to control mixed phenotype acute leukemia. (mdanderson.org)
  • At noneffective low doses of Taxol or vincristine, the addition of a noneffective dose of PDMP resulted in 70% cytotoxicity, indicating synergy. (aacrjournals.org)
  • PURPOSE: This phase I trial is studying the side effects and best dose of irinotecan when given together with temozolomide and vincristine in treating young patients with refractory solid tumors. (clinicaltrials.gov)
  • Determine the maximum tolerated dose and recommended phase II dose of irinotecan when administered with temozolomide and vincristine in young patients with refractory solid tumors, including brain tumors. (clinicaltrials.gov)
  • This phase I study aimed to determine the recommended phase 2 dose of MIBG together with fixed doses of vincristine and irinotecan. (aacrjournals.org)
  • Irinotecan (20 mg/m 2 /dose IV) was given on days 0 to 4 and 7 to 11, with vincristine (1.5 mg/m 2 IV) on days 0 and 7. (aacrjournals.org)
  • MIBG is tolerable and active at 18 mCi/kg with standard doses of vincristine and irinotecan. (aacrjournals.org)
  • This phase II trial studies how well clofarabine, idarubicin, cytarabine, vincristine sulfate, and dexamethasone work in treating patients with mixed phenotype acute leukemia that is newly diagnosed or has returned after a period of improvement (relapsed). (clinicaltrials.gov)
  • Acute lymphoblastic leukemia (L3) was initially diagnosed because of poor staining of alpha-naphtyl butylate esterase and induction chemotherapy with the LVP regimen (L-asparaginase 5,000 U/m2 day 8-21, vincristine 1.5 mg/ m2 day 1, 6, 11, 16, 21, 26, prednisolone 40 mg/m2 day 1-28) was performed. (unboundmedicine.com)
  • Vincristine is delivered via intravenous infusion for use in various types of chemotherapy regimens. (wikipedia.org)
  • Vincristine liposomal is given as an infusion into the vein (intravenous, IV) over 1 hour. (chemocare.com)
  • Vincristine is only administered to patients in an infusion center, clinic or hospital. (lymphoma.org)
  • This improved pharmacokinetic profile, which mimics a continuous vincristine infusion, potentially results in greater activity in rapidly dividing cancers. (cancernetwork.com)
  • We added a slow infusion of 2mg Vincristine (VCR) and followed by another 2 dosed of 1 mg with 6 days between each dose resulting in successful clinical and laboratory improvement. (omicsonline.org)
  • In the single-arm trial (HBS407 trial), 2 65 patients aged ≥ 18 years with Ph- ALL in second or greater relapse or whose disease had progressed after at least two antileukemia treatments received liposomal vincristine via IV infusion at 2.25 mg/m 2 over 60 minutes every 7 days. (ascopost.com)
  • Liposomal vincristine is given at 2.25 mg/m 2 via IV infusion over 1 hour once every 7 days. (ascopost.com)
  • In this study, lactoferrin- and arginine-glycine-aspartic acid (RGD) dual-ligand-comodified, temozolomide and vincristine-coloaded nanostructured lipid carriers (L/R-T/V-NLCs) were introduced for GBM combination therapy. (dovepress.com)
  • Second-line chemotherapy with temozolomide in recurrent oligodendroglioma after PCV (procarbazine, lomustine and vincristine) chemotherapy: EORTC B. (nih.gov)
  • Second-line chemotherapy with temozolomide in recurrent oligodendroglioma after PCV (procarbazine, lomustine and vincristine) chemotherapy: EORTC Brain Tumor Group phase II study 26972. (nih.gov)
  • Why has the drug temozolomide replaced the combination of procarbazine, carmustine and vincristine? (healthtap.com)
  • Do not receive any kind of immunization or vaccination without your doctor's approval while taking vincristine liposomal. (chemocare.com)
  • No patients have reported taking Vincristine liposomal. (patientslikeme.com)
  • VINCRISTINE (vin KRIS teen) is a chemotherapy drug. (cvs.com)
  • Vincristine liposomal is an anti-cancer ("antineoplastic" or "cytotoxic") chemotherapy drug. (chemocare.com)
  • Liposomal vincristine is a standard chemotherapy drug for patients with acute lymphoblastic leukemia (ALL). (mskcc.org)
  • Oligodendroglial tumors are chemosensitive, with two-thirds of patients responding to PCV combination chemotherapy with procarbazine, lomustine (CCNU) and vincristine. (nih.gov)
  • Vincristine belongs to the group of medicines known as antineoplastic agents. (mayoclinic.org)
  • Presently, there are no reliable means of identifying patients at high risk of vincristine induced neuropathy nor strategies to reduce vincristine toxicity. (medindia.net)
  • Vincristine, a major player in front line combination chemotherapy of cancer reduces testosterone levels contributing to reproductive toxicity. (ijpsonline.com)
  • The toxicity and antitumor activity of liposomal vincristine preparations have been examined. (aacrjournals.org)
  • The combined effects of decreased toxicity and increased antitumor efficacy of liposomal vincristine over free drug suggest significant clinical utility of appropriate liposomal vincristine systems. (aacrjournals.org)
  • If vincristine leaks into the tissues around the vein, it can cause damage to the tissue there. (netdoctor.co.uk)
  • Vincristine should be administered only into a vein. (medlineplus.gov)
  • If vincristine leaks out of the vein into the surrounding area, it may cause serious skin and tissue damage. (webmd.com)
  • Vincristine is injected into a vein through an IV. (adventisthealthcare.com)
  • Vincristine is injected into a vein through a specially prepared site on your skin that has been prepared for this purpose. (medbroadcast.com)
  • An organic sulfate salt containing equimolar amounts of vincristine(2+) and sulfate. (ebi.ac.uk)
  • These characteristics are intended to increase the dose of vincristine delivered in a safe and effective manner. (ascopost.com)
  • Nurses were trained using a video tutorial on the safe mini-bag administration of vincristine to avoid extravasation, before using the new procedure with patients. (cancernetwork.com)
  • campaign to promote new guidelines urging the safe dilution and drip administration of vincristine in order to avoid the risk of preventable, fatal clinical errors associated with syringe delivery. (cancernetwork.com)
  • Prior to administration of vincristine family and patient history as well as physical examination should be performed carefully to look for underlying hereditary neuropathy. (prohealth.com)
  • Vincristine Sulphate Pharmachemie may be available in the countries listed below. (drugs.com)
  • A significant series of inadvertent intrathecal vincristine administration occurred in China in 2007 when batches of cytarabine and methotrexate (both often used intrathecally) manufactured by the company Shanghai Hualian were found to be contaminated with vincristine. (wikipedia.org)
  • Vincristine liposomal is NOT intended for intrathecal (spinal cord/brain) use. (chemocare.com)
  • Vincristine is cancer medication that interferes with the growth of cancer cells and slows their spread in the body. (adventisthealthcare.com)
  • Vincristine may also be used for other purposes not listed in this medication guide. (adventisthealthcare.com)
  • A downside, however, to Vincristine is that it does not only affect the division of cancer cells. (wikipedia.org)
  • Vincristine works by stopping the cancer cells from multiplying. (netdoctor.co.uk)
  • Vincristine works by preventing the cancer cells from entering the dividing stage (mitosis) of their life cycle. (netdoctor.co.uk)
  • Vincristine is used to treat various types of cancer . (webmd.com)
  • Vincristine is sometimes used in combination with other cancer medications. (adventisthealthcare.com)
  • Vincristine interferes with the growth of cancer cells, which are eventually destroyed. (mayoclinic.org)
  • Vincristine stops the cancer cells growing and eventually kills them. (mydr.com.au)
  • Vincristine belongs to the group of cancer-fighting medications known as antineoplastics . (medbroadcast.com)
  • As well as interfering with the genetic material DNA of cancer cells, vincristine can interfere with some of your normal cells. (medbroadcast.com)
  • Zhou X, Zhang Y, Li Y, Hao X, Liu X, Wang Y. Azithromycin Synergistically Enhances Anti-Proliferative Activity of Vincristine in Cervical and Gastric Cancer Cells. (mdpi.com)
  • By blocking Bcl-2, venetoclax could kill ALL cells and/or make them more vulnerable to the effects of other cancer treatments, such as liposomal vincristine. (mskcc.org)
  • Use of a cancer drug called Vincristine may cause damage to the peripheral nervous system (neuropathy) as it can have a toxic effect on the nerves. (rightdiagnosis.com)
  • Why vincristine is one of the most used cancer drug? (healthtap.com)
  • Vincristine is the active ingredient in a drug used to treat acute leukemia. (news-medical.net)
  • Vincristine is the active ingredient of vincristine sulfate. (cancer.gov)
  • The initial proposed method provides a jolly useful tool looks for the assay of Vincristine liposome and Telotristat in food chain analysis, pharmaceutical analysis and clinical diagnosis. (dreamakergifts.com)
  • His oncologist wants to immediately put him on a chemo regimen of Carboplatin and Vincristine. (cancer.org)
  • He's starting on a chemo regimen of Carboplatin and Vincristine next week and we can't help wondering if this is the right, necessary route. (cancer.org)
  • Vincristine is in a class of medications called vinca alkaloids. (medlineplus.gov)
  • Vincristine lipid complex is in a class of medications called vinca alkaloids. (medlineplus.gov)
  • Unlike some of the other vinca alkaloids, vincristine does not cause severe bone marrow suppression (decreased blood cell counts). (cancerquest.org)
  • Vincristine sulfate belongs to a group of anticancer medicines called Vinca alkaloids. (mydr.com.au)
  • Vincristine, a microtubule inhibitor, is FDA-approved for ALL. (ascopost.com)
  • The microtubule inhibitor vincristine is currently used to treat a variety of brain tumors, including low-grade glioma and anaplastic oligodendroglioma. (molmed.org)
  • We also compared the therapeutic efficacy of mebendazole and vincristine against GL261 orthotopic tumors. (molmed.org)
  • We found that mebendazole showed a significant increase in animal survival time, whereas vincristine, even at a dose close to its maximum tolerated dose, failed to show any efficacy. (molmed.org)
  • Vincristine is widely used and an effective anticancer agent for treating leukemias in both adults and children. (medindia.net)
  • Vartika Rai, Pramod Kumar Tandon, and Sayyada Khatoon, "Effect of Chromium on Antioxidant Potential of Catharanthus roseus Varieties and Production of Their Anticancer Alkaloids: Vincristine and Vinblastine," BioMed Research International , vol. 2014, Article ID 934182, 10 pages, 2014. (hindawi.com)
  • The new product is a novel, targeted formulation of the FDA-approved anticancer drug vincristine. (ascopost.com)
  • These results suggest that neuroblastoma cells are normally able to metabolically remove excess Cer, but lose this capacity upon exposure to microtubule modulating anticancer agents (Taxol or vincristine). (aacrjournals.org)
  • OBJECTIVES: I. Determine the maximum tolerated dose of bryostatin 1 when combined with vincristine in patients with B-cell malignancies. (bioportfolio.com)
  • Background: Vincristine has been used as standard therapy for adult and pediatric malignancies for 50 years. (aacrjournals.org)
  • The main side effects of vincristine are chemotherapy-induced peripheral neuropathy, hyponatremia, constipation, and hair loss. (wikipedia.org)
  • Vincristine can cause severe constipation. (adventisthealthcare.com)
  • Vincristine is chiefly used as one drug in multi-drug combination protocols against lymphoid and round cell tumors. (marvistavet.com)
  • Vincristine is not able to pass through the blood/brain barrier and thus cannot treat tumors in the nervous system. (marvistavet.com)
  • Can vascular tumors in infants be treated with a drug called vincristine? (healthtap.com)
  • Vincristine liposomal is used to treat Acute Lymphoblastic Leukemia (ALL: Philadelphia chromosome-negative), relapsed. (chemocare.com)
  • We describe a patient presenting with a first episode of acute refractory TTP in whom remission was not achieved by PE & steroids who was successfully treated with vincristine (VCR). (omicsonline.org)
  • Prohealth Acute deterioration of Charcot-Marie-Tooth disease IA (CMT IA) following 2 mg of vincristine chemotherapy. (prohealth.com)
  • Chemotherapy-induced peripheral neuropathy can be severe, and may be a reason to reduce or avoid using vincristine. (wikipedia.org)
  • One of the first symptoms of peripheral neuropathy is foot drop: A person with a family history of foot drop and/or Charcot-Marie-Tooth disease (CMT) should avoid the taking of vincristine. (wikipedia.org)
  • Researchers performed a genome-wide association study to determine whether there are genetic variants associated with vincristine-induced neuropathy. (medindia.net)
  • Grade 2 (moderate) to grade 4 (life threatening) vincristine-induced neuropathy during therapy occurred in 28.8 percent of patients (64/222) in the St. Jude cohort and in 22.2 percent (22/99) in the COG cohort. (medindia.net)
  • Vincristine-induced neuropathy in rat: electrophysiological and histological study. (springer.com)
  • Severe up to life-threatening neuropathy has been observed in patients with hereditary neuropathies receiving vincristine. (prohealth.com)
  • Vincristine tends to primarily affect sensation and muscle movement (sensorimotor neuropathy). (rightdiagnosis.com)
  • Bradykinin receptors antagonists and nitric oxide synthase inhibitors in vincristine and streptozotocin induced hyperalgesia in chemotherapy and diabetic neuropathy rat model. (nel.edu)
  • 70 nmol/kg ip) or des Arg10 HOE 140 (70 nmol/kg ip) respectively, in model of diabetic (streptozotocin-induced) and toxic (vincristine-induced) neuropathy was investigated. (nel.edu)
  • The overuse of vincristine may also lead to drug resistance by overexpression of the p-glycoprotein pump (Pgp). (wikipedia.org)
  • Vincristine is also a drug whose metabolism depends on the P-glycoprotein. (marvistavet.com)
  • The JCAHO has advised hospitals to make sure Vincristine syringes are properly labeled with warnings that spinal injections are fatal, and that the drug is for intravenous use only. (yourlawyer.com)
  • A model drug, vincristine sulfate, was physically conjugated with gold nanoparticles and verified by UV-visible and fourier transform infrared spectroscopy, and differential scanning calorimetry. (dovepress.com)
  • Patient's will also be given the drug docusate by the day liposomal vincristine is started. (knowcancer.com)
  • In this study, a novel drug delivery system of vincristine-loaded platelets coated with anti-CD41 mAbs (CD41-VCR-PLT, CD41-VLP) was successfully established. (rsc.org)
  • Vincristine was encapsulated inside egg phosphatidylcholine (EPC)/cholesterol (55/45, mol/mol) and distearoylphosphatidylcholine (DSPC)/cholesterol (55/45, mol/mol) vesicles utilizing transmembrane pH gradient (inside acidic) drug uptake processes. (aacrjournals.org)
  • Thirty-day dose-response survival studies in mice indicated that vincristine encapsulated in DSPC/cholesterol liposomes was less toxic than free drug. (aacrjournals.org)
  • Any ideas why the drug vincristine have side effects such as loss of dividing cells an nerve problems? (healthtap.com)
  • Why does the drug vincristine have side effects? (healthtap.com)
  • How can the chemo therapy drug vincristine be harmful? (healthtap.com)
  • What is the drug vincristine used for? (healthtap.com)
  • Does the drug vincristine cause blood clots in the bowel, grandad had rcvp them had a blood clot in the major artery supplying the bowel? (healthtap.com)
  • Vincristine lipid complex may cause side effects. (medlineplus.gov)
  • See the full vincristine side effects document. (drugs.com)
  • Along with their needed effects, medicines like vincristine can sometimes cause unwanted effects such as blood problems, nervous system problems, loss of hair, and other side effects. (mayoclinic.org)
  • What are the possible side effects of vincristine? (adventisthealthcare.com)
  • There is no relationship between the presence or severity of side effects and the effectiveness of vincristine liposomal. (chemocare.com)
  • However, if you are given too much vincristine, you may experience some of the effects listed under 'Side Effects' below. (mydr.com.au)
  • Vincristine has some potential for neurologic side effects, especially in cats. (marvistavet.com)
  • Vincristine Side Effects Can Cause Paralysis. (yourlawyer.com)
  • Need Legal Help Regarding Vincristine Side Effects? (yourlawyer.com)
  • All patients who show a continued response or stable disease without major side effects may continue to receive liposomal vincristine for up to 24 months. (knowcancer.com)
  • What are the warnings and precautions for Vincristine? (medindia.net)